CN115054544A - Anti-allergy soothing foundation formula rich in yeast fermentation broth Supferm PO and preparation method thereof - Google Patents
Anti-allergy soothing foundation formula rich in yeast fermentation broth Supferm PO and preparation method thereof Download PDFInfo
- Publication number
- CN115054544A CN115054544A CN202210569369.9A CN202210569369A CN115054544A CN 115054544 A CN115054544 A CN 115054544A CN 202210569369 A CN202210569369 A CN 202210569369A CN 115054544 A CN115054544 A CN 115054544A
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- Prior art keywords
- homogenizing
- supferm
- component
- allergy
- soothing
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Abstract
The invention discloses an anti-allergy soothing foundation formula rich in yeast fermentation broth Supferm PO and a preparation method thereof. The base makeup comprises an emulsifier, powders, a film-forming agent, an emollient, a thickening agent, a conditioner, a preservative, a humectant and an anti-allergy soothing agent in percentage by mass, and the balance is yeast fermentation liquor; the anti-allergy soothing agent is BLUSH Oolactif, and the yeast fermentation liquid is Supferm PO. The invention reduces the amount of IL 1-alpha on skin tissues by relieving the reaction of inflammatory factor siren IL-1 alpha, thereby achieving good anti-allergy and soothing properties. The formula has good applicability to common skin, is friendly to sensitive skin, solves the problem that the sensitive skin crowd difficultly selects a base makeup product, and can meet the requirements of current consumers on skin nourishing base makeup.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to an anti-allergy soothing foundation formula rich in yeast fermentation broth Suferm PO and a preparation method thereof.
Background
The sensitive skin refers to a high-response state of the skin under physiological or pathological conditions, mainly occurs on the face, and is clinically manifested by subjective symptoms such as burning, stabbing pain, itching and tightness of the skin easily appearing when the skin is stimulated by physical, chemical and mental factors, and objective signs such as erythema, scaling and telangiectasia are accompanied or not accompanied. With the increasing environmental pollution and the increasing mental stress, the neurotensin can be reflexively released, thereby triggering sensitive skin.
The report shows that Chinese sensitive muscle women account for 36% of global sensitive muscle women, are mainly mild women bearing urban living pressure and generally make up at high frequency, and the skin sensitivity of more than seven sensitive muscle women is weak or mild. For a long time, people with sensitive muscles, which account for more than 30% of the population, have been choosing between making up and not making up. Sensitive muscle women choose cosmetics most care should be taken whether the product is safe and non-irritating to the skin. The attention degree of the people with sensitive muscles to the mild components of the product is positively correlated with the skin sensitivity degree.
In the previous sensitive muscle make-up process, due to the sensitive body feeling of skin, most of traditional commercially available base make-up products have the discomfort of 'face pricking', 'acne smothering', 'reddish pruritus' and the like, and meanwhile, the thick and heavy floating powder is more normal based on the common skin state of the sensitive muscle.
Because the inventor of the application provides a one-stop solution for selecting the foundation for the people with sensitive muscles, the anti-allergy and soothing foundation formula which is mild, soothing and rich in yeast fermentation liquor Suferm PO is created through different matching designs and technologies while solving the traditional pain points.
Disclosure of Invention
The invention relates to a novel base makeup formula, the selected raw materials of the formula are not allergic, the formula has certain safety, and the anti-allergic and relieving base makeup formula rich in yeast fermentation liquor Suferm PO and the formula are provided aiming at the current situation that acne, face pricking and the like are easy to occur when base makeup products are used by people with sensitive muscles at present.
The purpose of the invention is realized by at least one of the following technical solutions.
An anti-allergy soothing foundation formula rich in yeast fermentation broth Suferm PO is characterized by comprising, by mass, 4% -6% of an emulsifier, 10% -18% of a powder, 8% -15% of a film-forming agent, 20% -30% of an emollient, 1% -2% of a thickening agent, 2% -6% of a conditioner, 0.5% -2% of a preservative, 10% -15% of a humectant, 0.5% -2% of an anti-allergy soothing agent, and the balance of yeast fermentation broth; the anti-allergy soothing agent is BLUSH Oolactif, and the yeast fermentation liquid is Supferm PO.
The preparation process of the Supferm PO comprises the following steps: preparing a potato fermentation substrate and microzyme as fermentation substrates, inoculating 10g of microzyme C-SFF-9 bacterial liquid into 300g of the potato fermentation substrate, and carrying out fermentation culture for 36 hours at the temperature of 25 ℃ under the stirring condition, wherein the stirring rotating speed is 170 rpm; transferring the prepared material into a centrifuge, centrifuging for 30min at the rotation speed of 4000rpm, collecting supernatant, and sterilizing the supernatant for 30min at 90 ℃; and (4) after sterilization, cooling, and mixing with a preservative at 70 ℃ to obtain the target product Suferm PO.
The film forming agent is an acrylic acid (ester) film forming agent and an MQ resin film forming agent which are matched according to the mass ratio of 1-2: 4-6, and the preferred ratio is 1: 6.
The base makeup formula comprises foundation liquid, cream, isolation cream or concealer.
More preferably, the emulsifier is at least one of KSG-840 (lauryl dimethyl silicone/polyglycerol-3 cross-linked polymer) and KF-6105 (lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethyl silicone).
More preferably, the powder is one or more of KTP series, TAY-MP1133-AES and SOLAVEIL XTP-1. Wherein the KTP series is iron oxide (and) triethoxysilylethyl polydimethylsiloxyethyl hexyl polydimethylsiloxane, wherein the iron oxide comprises yellow iron oxide, black iron oxide, and red iron oxide. TAY-MP1133-AES is titanium dioxide (and) triethoxyoctylsilane. SOLAVAIL XTP-1 is titanium dioxide (and) stearic acid (and) alumina.
Further preferably, the acrylic film former comprises an acrylic/dimethicone copolymer (and) dimethicone or an acrylic/dimethicone copolymer (and) isododecane; the MQ resin film former comprises trimethylsiloxysilicate (and) polydimethylsiloxane or trimethylsiloxysilicate (and) isododecane.
More preferably, the emollient is one or more selected from polydimethylsiloxane, butyl octanol salicylate and ethylhexyl hydroxystearate.
More preferably, the thickener is one or more of disteardimonium hectorite or xanthan gum.
Further preferably, the conditioning agents are KSG-19 (dimethicone (and) dimethicone/vinyl dimethicone crosspolymer), KMP-590 (polymethylsilsesquioxane) and KSP-300 (diphenyl dimethicone/vinyl diphenyl dimethicone/silsesquioxane crosspolymer).
Further preferably, the preservative is p-hydroxyacetophenone.
Further preferably, the humectant is glycerin, butylene glycol, and 1, 2-hexanediol.
Further preferably, the anti-allergy soothing agent is BLUSH oeactif (rape (Brassica CAMPESTRIS) seed oil, Polygonum TINCTORIUM (Polygonum TINCTORIUM) leaf extract, and Rosmarinus OFFICINALIS (Rosmarinus OFFICINALIS) leaf extract).
Further preferably, the yeast fermentation broth is Supferm PO (yeast/potato extract fermentation product filtrate, 1, 2-hexanediol, p-hydroxyacetophenone).
The invention relates to a preparation method of an anti-allergy soothing foundation formula rich in yeast fermentation broth Supferm PO, which comprises the following steps:
step 1: dispersing one of the thickeners with a part of emollient, adding an emulsifier, and homogenizing at a high speed, wherein the homogenizing force is 3000-8000 r/min, and the homogenizing time is 3-10 min, so as to obtain a component A;
step 2: mixing powder and an emollient, homogenizing and dispersing with the homogenizing force of 3000-8000 r/min and the homogenizing time of 3-10 min to obtain a component B;
and step 3: uniformly mixing the component A and the component B to obtain a component C;
and 4, step 4: sequentially adding a film forming agent, an anti-allergy soothing agent and a part of conditioner into the component C, and homogenizing at a low speed, wherein the homogenizing force is 3000-8000 r/min, and the homogenizing time is 3-10 min to obtain a component D;
and 5: heating the preservative and the humectant to 60-85 ℃ and stirring for 5-10 min until the preservative and the humectant are dissolved, adding one of the thickeners for dispersion, then adding part of the conditioner and the yeast fermentation liquor for dissolution and low-speed homogenization, wherein the homogenization force is 3000-8000 r/min, and the homogenization time is 3-10 min, so as to obtain a component E;
step 6: slowly adding the component E into the component D in a stirring state at the speed of a stirrer of 400-500 r/min, and homogenizing the component D by using a homogenizer at the homogenization force of 3000-8000 r/min for 3-10 min after the component E is completely added; and stirring at the speed of 500-700 r/min for 3-5 min after homogenizing to obtain the target base makeup formula.
The base makeup formula has certain scrutiny in the aspects of safety of raw material selection, integral matching of the formula and the like, and particularly deionized water in the formula is replaced by yeast fermentation liquor Supferm PO to form an anhydrous formula, so that the Supferm PO can effectively inhibit over-expression of KLK7 and reduce inflammation; adding anti-allergy soothing agent BLUSH Ol oectif to protect the keratinocyte from being damaged by pollutants and ultraviolet rays; by alleviating the response of the inflammatory factor, siren IL-1 α, the amount of IL1- α on the skin tissue is significantly reduced. The formula has good applicability to common skin, is friendly to sensitive muscles, solves the problem that the sensitive muscles are difficult to select base makeup products, and can meet the requirements of current consumers on skin nourishing base makeup.
Compared with the prior art, the invention has the advantages that:
the invention has the unique characteristics of safety, reliability, no allergic component and being friendly to people with sensitive muscles; secondly, the deionized water is completely replaced by yeast fermentation broth Supferm PO, and the yeast fermentation broth Supferm PO comprises yeast/potato extract fermentation product filtrate, 1, 2-hexanediol and p-hydroxyacetophenone. Kallikrein (KLK) is a member of the serine protease family, and in particular KLK7, expressed in large amounts in the human epidermis plays an important role in maintaining normal physiological activities of the skin. Studies have shown that Atopic Dermatitis (AD), an inflammatory skin-like disease closely related to genetics, is closely linked to an increase in the activity of KLK7 in the epidermis. There is no cure for atopic dermatitis, and KLK7 is a potential drug target for treating atopic dermatitis, so that the development of KLK7 inhibitors will help to provide a new idea for clinical treatment of inflammatory skin diseases such as atopic dermatitis. And the yeast fermentation broth Supferm PO can effectively inhibit over-expression of KLK7, reduce inflammation and greatly help human bodies. Mixing with anti-allergy soothing agent BLUSH Ol oectif including rape (Brassica CAMPESTRIS) seed oil, Polygonum TINCTORIUM (Polygonum TINCTORIUM) leaf extract, and Rosmarinus OFFICINALIS (Rosmarinus OFFICINALIS) leaf extract, and protecting keratinocyte from pollutant and ultraviolet ray; by relieving the reaction of inflammatory factor siren IL-1 alpha, the quantity of IL 1-alpha on skin tissues is obviously reduced, and the skin cream has good anti-inflammatory and soothing capabilities, promotes the appearance health of skin and can improve the skin state of people with sensitive muscles.
Moreover, the invention has unique matching in formula design: firstly, the water-in-silicone oil emulsifier is selected, and a formula system mainly containing silicone oil is adopted, so that the skin feeling is fresh and cool compared with the traditional water-in-oil system, the spreadability is good, and the phenomenon of heavy acne is not easy to occur; secondly, the invention selects the matching of two film forming agents, wherein one film forming agent is an acrylic acid (ester) film forming agent, and the presented film is a soft film; one is MQ resin film forming agent, and the presented film is hard film. The soft film is matched with the hard film, so that the air permeability is good, and the skin sticking performance is good; thirdly, the invention selects two types of titanium dioxide with different particle sizes to match, and the titanium dioxide with large particle size is the main titanium dioxide, so that the invention has good concealing effect; the small-particle-size titanium dioxide is used as an auxiliary material, and the effect of full coverage and no gap is required in the cosmetic effect.
Therefore, the base make-up formula disclosed by the invention is integrally matched in terms of raw material selection and sensory experience, has the advantages of better mildness, safety, skin friendliness, no irritation, simple preparation method, wide application range and the like.
Drawings
FIG. 1 is a graph showing that Supferm PO was effective in inhibiting the overexpression of KLK 7;
FIG. 2a is a diagram of a BLUSH Ol θ ctif protective skin barrier;
FIG. 2b is a graph of self-feedback BLUSH Octiff efficacy compared to placebo;
FIG. 3 is a graph comparing the BLUSH oeactatif effect on reducing skin redness and vasodilation;
FIG. 4 is a health diagram of BLUSH Oloectif promoting the appearance of skin;
FIG. 5 is a comparison of the results obtained after using a cream containing BLUSH Olicoctif.
Detailed Description
The present invention is further illustrated by the following examples.
The test materials adopted by the invention are all common commercial products and can be purchased in the market. The BLUSH oeactatif comprises rape (Brassica CAMPESTRIS) seed oil, Polygonum TINCTORIUM (Polygonum TINCTORIUM) leaf extract, and Rosmarinus OFFICINALIS (Rosmarinus OFFICINALIS) leaf extract, and has effects of relieving inflammatory reaction of siren IL-1 alpha, reducing skin redness, and promoting skin appearance health. The Supferm PO comprises yeast/potato extract fermentation product filtrate, 1, 2-hexanediol and p-hydroxyacetophenone, can effectively inhibit over-expression of KLK7, and reduces inflammation.
The preparation method of Supferm PO used in the following examples was: preparing a potato fermentation substrate and saccharomycetes as fermentation substrates, inoculating 10g of saccharomycetes C-SFF-9 bacterial liquid (the saccharomycetes is a saccharomyces cerevisiae strain with the preservation number of CGMCC 17452) into 300g of the potato fermentation substrate, and performing fermentation culture for 36 hours under the conditions of 25 ℃ and stirring at the rotating speed of 170 rpm; transferring the prepared material into a centrifuge, centrifuging for 30min at the rotation speed of 4000rpm, collecting supernatant, and sterilizing the supernatant for 30min at 90 ℃; and (4) after sterilization, cooling, and mixing with a preservative at 70 ℃ to obtain the target product Suferm PO.
The preparation process of the BLUSH Ol oactif comprises the following steps: after harvesting the Polygonum tinctorium leaves, soaking the Polygonum tinctorium leaves in water for several hours to several days, and then filtering the solution to obtain blue filter residues; drying the filter residue until the water content is 10%, and grinding at low temperature to obtain blue powder. Mixing the powder with rapeseed oil, under the protection of nitrogen, generating external stress and internal stress under the action of high-energy microwave and low-energy ultrasonic wave, breaking plant cell wall, and extracting active ingredients efficiently. And then the target product BLUSH Oloectif is obtained by micro-pore filtration.
Example 1: cosmetics were formulated according to the formulation of table 1 as one of the foundation lotions in the foundation formulation.
Table 1
Step 1: dispersing disteardimonium hectorite with ethylhexyl hydroxystearate, adding lauryl dimethyl silicone polymer/polyglycerol-3 cross-linked polymer and lauryl polyglycerol-3 polydimethylsiloxyethyl polydimethylsiloxane, and homogenizing at high speed with homogenization force of 5000r/min and homogenization time of 5min to obtain component A; step 2: mixing titanium dioxide (and) triethoxyoctylsilane, titanium dioxide (and) stearic acid (and) alumina, ferric oxide (and) triethoxysilylethyl polydimethylsiloxyethyl hexyl polydimethylsiloxane, polydimethylsiloxane and butyl octanol salicylate, homogenizing and dispersing with the homogenizing force of 5000r/min and the homogenizing time of 5min to obtain a component B;
and step 3: uniformly mixing the component A and the component B to obtain a component C;
and 4, step 4: sequentially adding trimethylsiloxy silicate (and) polydimethylsiloxane, acrylic acid (ester)/polydimethylsiloxane copolymer (and) polydimethylsiloxane, BlUSH Oleactatif and polydimethylsiloxane, polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer, polymethylsilsesquioxane, diphenyl polydimethylsiloxane/vinyl diphenyl polydimethylsiloxane/silsesquioxane cross-linked polymer into the component C, homogenizing at low speed, wherein the homogenizing force is 5000r/min, and the homogenizing time is 5min to obtain a component D;
and 5: 1, 2-hexanediol, glycerol, butanediol and p-hydroxyacetophenone are heated to 60-85 ℃ under the heat preservation condition and stirred for 5-10 min until the mixture is dissolved, xanthan gum is added for dispersion, then sodium chloride and Supferm PO are added for dissolution, and the mixture is homogenized at a low speed, wherein the homogenization force is 5000r/min, and the homogenization time is 5min, so as to obtain a component E;
step 6: slowly adding the component E at a speed of 500r/min in the stirring state of the component D, and homogenizing with a homogenizer at a homogenizing force of 5000r/min for 5 min; stirring at the speed of 600r/min for 5min after homogenizing to obtain the target foundation solution formula.
Example 2
The cosmetic was formulated according to the formula in table 2, as one of the creams in the makeup base formula.
Table 2
Step 1: dispersing disteardimonium hectorite with ethylhexyl hydroxystearate, adding lauryl dimethyl silicone polymer/polyglycerol-3 cross-linked polymer and lauryl polyglycerol-3 polydimethylsiloxyethyl polydimethylsiloxane, and homogenizing at high speed with homogenization force of 5000r/min and homogenization time of 5min to obtain component A;
step 2: mixing titanium dioxide (and) triethoxyoctylsilane, titanium dioxide (and) stearic acid (and) alumina, ferric oxide (and) triethoxysilylethyl polydimethylsiloxyethyl hexyl polydimethylsiloxane, polydimethylsiloxane and butyl octanol salicylate, homogenizing and dispersing with the homogenizing force of 5000r/min and the homogenizing time of 5min to obtain a component B;
and step 3: uniformly mixing the component A and the component B to obtain a component C;
and 4, step 4: sequentially adding trimethylsiloxy silicate (and) polydimethylsiloxane, acrylic acid (ester)/polydimethylsiloxane copolymer (and) polydimethylsiloxane, BlUSH Oleactatif and polydimethylsiloxane, polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer, polymethylsilsesquioxane, diphenyl polydimethylsiloxane/vinyl diphenyl polydimethylsiloxane/silsesquioxane cross-linked polymer into the component C, homogenizing at low speed, wherein the homogenizing force is 5000r/min, and the homogenizing time is 5min to obtain a component D;
and 5: heating 1, 2-hexanediol, glycerol, butanediol and p-hydroxyacetophenone to 60-85 ℃ at a constant temperature, stirring for 5-10 min until the mixture is dissolved, adding xanthan gum for dispersion, then adding sodium chloride and Supferm PO, dissolving, and homogenizing at a low speed, wherein the homogenizing force is 5000r/min, and the homogenizing time is 5min to obtain a component E;
step 6: slowly adding the component E at a speed of 500r/min in the stirring state of the component D, and homogenizing with a homogenizer at a homogenizing force of 5000r/min for 5 min; stirring at the speed of 600r/min for 5min after homogenizing to obtain the target cream formula.
Example 3
The cosmetic was formulated according to the formula in table 3 as one of the barrier creams in the make-up base formula.
Table 3
Step 1: dispersing disteardimonium hectorite with ethylhexyl hydroxystearate, adding lauryl dimethyl silicone polymer/polyglycerol-3 cross-linked polymer and lauryl polyglycerol-3 polydimethylsiloxyethyl polydimethylsiloxane, and homogenizing at high speed with homogenization force of 5000r/min and homogenization time of 5min to obtain component A;
step 2: mixing titanium dioxide (and) triethoxyoctylsilane, ethylhexyl methoxycinnamate, ferric oxide (and) triethoxysilylethyl polydimethylsiloxyethylhexyl polydimethylsiloxane, polydimethylsiloxane and butyl octanol salicylate, homogenizing at the homogenizing force of 5000r/min for 5min to obtain component B;
and 3, step 3: uniformly mixing the component A and the component B to obtain a component C;
and 4, step 4: sequentially adding trimethylsiloxy silicate (and) polydimethylsiloxane, acrylic acid (ester)/polydimethylsiloxane copolymer (and) polydimethylsiloxane, BlUSH Oleactatif and polydimethylsiloxane, polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer, polymethylsilsesquioxane, diphenyl polydimethylsiloxane/vinyl diphenyl polydimethylsiloxane/silsesquioxane cross-linked polymer into the component C, homogenizing at low speed, wherein the homogenizing force is 5000r/min, and the homogenizing time is 5min to obtain a component D;
and 5: heating 1, 2-hexanediol, glycerol, butanediol and p-hydroxyacetophenone to 60-85 ℃ at a constant temperature, stirring for 5-10 min until the mixture is dissolved, adding xanthan gum for dispersion, then adding sodium chloride and Supferm PO, dissolving, and homogenizing at a low speed, wherein the homogenizing force is 5000r/min, and the homogenizing time is 5min to obtain a component E;
step 6: slowly adding the component E at a speed of 500r/min in the stirring state of the component D, and homogenizing with a homogenizer at a homogenizing force of 5000r/min for 5 min; stirring at the speed of 600r/min for 5min after homogenizing to obtain the target isolation emulsion formula.
Example 4
The cosmetic was formulated according to the formula in table 4, as one of the concealers in the make-up base formula.
TABLE 4
Step 1: dispersing disteardimonium hectorite with ethylhexyl hydroxystearate, adding lauryl dimethyl silicone polymer/polyglycerol-3 cross-linked polymer and lauryl polyglycerol-3 polydimethylsiloxyethyl polydimethylsiloxane, and homogenizing at high speed with homogenization force of 5000r/min and homogenization time of 5min to obtain component A;
step 2: mixing titanium dioxide (and) triethoxyoctylsilane, titanium dioxide (and) stearic acid (and) alumina, ferric oxide (and) triethoxysilylethyl polydimethylsiloxyethyl hexyl polydimethylsiloxane, polydimethylsiloxane and butyl octanol salicylate, homogenizing and dispersing with the homogenizing force of 5000r/min and the homogenizing time of 5min to obtain a component B;
and step 3: uniformly mixing the component A and the component B to obtain a component C;
and 4, step 4: sequentially adding the component C into candelilla wax, beeswax, ozokerite, trimethylsiloxysilicate (and) polydimethylsiloxane, acrylic acid (ester)/polydimethylsiloxane copolymer (and) polydimethylsiloxane, Blush Olioctif and polydimethylsiloxane, polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer, polymethylsilsesquioxane, diphenyl polydimethylsiloxane/vinyl diphenyl polydimethylsiloxane/silsesquioxane cross-linked polymer, heating to 80-85 ℃, homogenizing at low speed with the homogenizing force of 5000r/min and the homogenizing time of 5min to obtain a component D, and continuously keeping the temperature of the component D at about 85 ℃;
and 5: 1, 2-hexanediol, glycerol, butanediol and p-hydroxyacetophenone are heated to 60-85 ℃ under heat preservation and stirred for 5-10 min until the mixture is dissolved, xanthan gum is added for dispersion, then sodium chloride and Supferm PO are added for dissolution, and the mixture is homogenized at a low speed for 5min with the homogenization force of 5000r/min to obtain a component E, wherein the component E is kept at the temperature of about 85 ℃ under heat preservation;
step 6: slowly adding the component D into the stirrer at a speed of 500r/min under the condition of heat preservation and stirring, and homogenizing with a homogenizer when the component E is hot after the component D is added, wherein the homogenizing force is 5000r/min, and the homogenizing time is 5 min; discharging the homogeneous concealer while the homogeneous concealer is hot to obtain the concealer formula.
To demonstrate the excellent effects of the present invention, the inventors performed various tests on the novel formulation of the collocated liquid foundation prepared in example 1, and the specific experiments are as follows:
measurement of physical and chemical Properties
a) Measuring the viscosity of the foundation formula by using a rheometer, wherein the viscosity is 800-1000 mPa & s; b) stability test under external force: centrifuging the base makeup formula at the rotating speed of 2000r/min for 30min, and observing the water-oil phase separation condition of the base makeup formula, wherein the result shows that the base makeup formula has no phase separation condition; c) heat resistance, cold resistance, cycling test: the makeup base formula is placed in the circulating environment of resisting heat for 90 days at 48 ℃, resisting cold for 90 days at-18 ℃, resisting cold for 24 hours at 48 ℃, resisting normal temperature for 24 hours, and reacting at 24-18 ℃ (3 cycles in total), the separation condition of the water phase and the oil phase of the makeup base formula is observed, and the result shows that the makeup base formula is not separated in the circulating environment of 90 days of cold and heat and 3 cycles of cold and heat. The specific physicochemical basic properties are shown in table 5.
Table 5 example 1 basic physicochemical properties of anti-allergy soothing base make-up formulation rich in yeast broth Supferm PO
| No | Parameter(s) | Observation under specific conditions |
| 1 | Colour(s) | Skin color |
| 2 | Smell(s) | Characteristic odor, acceptable |
| 3 | Phase separation | No phase separation occurred |
| 4 | Centrifugal test | Homogeneous, phase separation free |
| 5 | Heat resistance test | No phase separation occurred at 48 ℃ for 90 |
| 6 | Cold resistance test | No phase separation occurred at-18 ℃ for 90 days |
| 7 | Cycle testing | 3 cycles, no phase separation occurred for 9 days |
User evaluation
The number of tested persons: 20 persons
Sex: 90% of women and 10% of men
The product is as follows: example 1, commercial product
The use times are as follows: the preparation is administered once a day, and is administered blindly for 1 week
Evaluation method: self-evaluation, the score is 5 points, 5 points are the best effect, and 1 point is the worst effect
Evaluation dimension: ductility, concealer level, make-up retention, film forming speed, darkness, floating powder condition, and after-use mildness.
Evaluation results were as follows: the highest score and the lowest score are removed by adopting all dimensions, and the results are shown in a table 6 by the rest averaging modes.
TABLE 6 evaluation results of after-trial cosmetic products
And (4) analyzing results: the concealer degree of the example 1 and the commercial products is close to the evaluation of the film forming speed, and the ductility, the make-up keeping performance, the darkness, the floating powder and the after-use mild condition are all higher than the scores of the commercial products, so that the overall feedback of the example 1 is as follows: good spreading property during makeup, good concealing degree, high film forming speed, difficult makeup removal and darkness and no obvious stimulation to skin after use.
In the present invention, the efficacy data of Supferm PO and BLUSH oectif are shown in fig. 1 to 5. In the in-vivo experiment, the volunteers are 40 women aged 30-50 years, Paris white in France, wearing masks in 6 hours per day, and the test time is in October to November. All volunteers were sensitive muscle and permanent facial skin reddened, and all were subjected to a double-blind randomized trial, comparing skin self-evaluation with 1% BLUSH oeactif versus placebo, for 28 days, using two full-face tests a day.
In FIG. 1, M is a Model set Model; c is blank group Control; under the irradiation of UVB, a large amount of KLK7 is expressed, and Supferm PO is added, so that the expression of KLK7 can be effectively inhibited.
FIG. 2a is a comparison with FIG. 2b of the results obtained after use of a cream containing BLUSH Olioctif, in which 79% of the volunteers considered their skin to be more comfortable after 28 days.
FIG. 3 shows that the cream containing BLUSH oactif reduces vasodilation and redness of the skin 28 days after application of the cream containing BLUSH oactif, compared to the cream containing BLUSH oactif.
FIG. 4 is a comparison of the use of a cream containing BLUSH Oactif before and after use, which shows that the use of a cream containing BLUSH Oactif after 28 days results in lightening the skin and increasing the skin's radiance.
FIG. 5 is a comparison after using a cream containing BLUSH Olloctif, after 28 days the vast majority of volunteers agree to these points: (1) their skin was healthier (74%); (2) their skin tone was more shiny (74%); (3) their skin appeared more vigorous (74%) and the sensitive, reddish-prone skin volunteers fed back an improvement in their skin tone. After observation for 4 weeks of use, feedback was given that the effect was superior to placebo.
Claims (10)
1. An anti-allergy soothing foundation formula rich in yeast fermentation broth Suferm PO is characterized by comprising, by mass, 4% -6% of an emulsifier, 10% -18% of powder, 8% -15% of a film forming agent, 20% -30% of an emollient, 1% -2% of a thickening agent, 2% -6% of a conditioner, 0.5% -2% of a preservative, 10% -15% of a humectant, 0.5% -2% of an anti-allergy soothing agent, and the balance of yeast fermentation broth; the anti-allergy soothing agent is BLUSH Olloctif, and the yeast fermentation liquor is Supferm PO;
the preparation process of the Supferm PO comprises the following steps: preparing a potato fermentation substrate and microzyme as fermentation substrates, inoculating 10g of microzyme C-SFF-9 bacterial liquid into 300g of the potato fermentation substrate, and carrying out fermentation culture for 36 hours at the temperature of 25 ℃ under the stirring condition, wherein the stirring rotating speed is 170 rpm; transferring the prepared material into a centrifuge, centrifuging for 30min at the rotation speed of 4000rpm, collecting supernatant, and sterilizing the supernatant for 30min at 90 ℃; sterilizing, cooling, and mixing with preservative at 70 ℃ to obtain the target product Supferm PO;
the film forming agent is an acrylate film forming agent and an MQ resin film forming agent which are matched according to the mass ratio of 1-2: 4-6;
the base makeup formula comprises foundation liquid, cream, isolation cream or concealer.
2. The anti-allergy soothing under-make formulation rich in yeast broth Supferm PO according to claim 1, characterized in that said emulsifier comprises more than one of lauryl dimethicone/polyglycerin-3 crosspolymer or lauryl polyglycerin-3 dimethiconoethyl dimethicone.
3. The anti-allergy soothing under-makeup formulation rich in yeast broth Supferm PO according to claim 1, characterized in that said powder comprises more than one of iron oxides and triethoxysilylethyl polydimethylsiloxyethyl hexyl polydimethylsiloxane, titanium dioxide and triethoxyoctylsilane or titanium dioxide and stearic acid and alumina.
4. Anti-allergy soothing make-up formulation rich in yeast broth Supferm PO according to claim 1, characterized in that said film-forming agent of acrylic acid (ester) type comprises copolymer of acrylic acid (ester)/polydimethylsiloxane (and) polydimethylsiloxane or copolymer of acrylic acid (ester)/polydimethylsiloxane (and) isododecane; the MQ resin film former comprises trimethylsiloxysilicate and polydimethylsiloxane or trimethylsiloxysilicate and isododecane.
5. The anti-sensitization and soothing foundation formulation enriched in yeast fermentation broth Supferm PO according to claim 1, wherein the emollient is one or more of polydimethylsiloxane, butyl octanol salicylate or ethylhexyl hydroxystearate.
6. The anti-allergy soothing base formulation rich in yeast fermentation broth Supferm PO according to claim 1, characterized in that said thickener is more than one of disteardimonium hectorite or xanthan gum.
7. The yeast fermentation broth Supferm PO-rich anti-allergy soothing base formulation according to claim 1, wherein the conditioning agent is one or more of dimethicone and dimethicone/vinyl dimethicone crosspolymer, polymethylsilsesquioxane or diphenyl dimethicone/vinyl diphenyl dimethicone/silsesquioxane crosspolymer.
8. The anti-allergy soothing base makeup formulation rich in yeast broth Supferm PO according to claim 1, characterized in that said preservative is p-hydroxyacetophenone;
the humectant is more than one of glycerin, butanediol or 1, 2-hexanediol.
9. Anti-allergy soothing make-up base formulation rich in yeast broth Supferm PO according to claim 1, characterized in that said BLUSH oectif is prepared by a process comprising: after harvesting the Polygonum tinctorium leaves, soaking the Polygonum tinctorium leaves in water for several hours to several days, and then filtering the solution to obtain blue filter residues; drying the filter residue until the water content is 6% -12%, and grinding at low temperature to obtain blue powder; mixing the powder with rapeseed oil, generating external stress and internal stress under the protection of nitrogen and the action of high-energy microwave and low-energy ultrasonic wave, breaking plant cell walls, and efficiently extracting active ingredients; and then filtering the solution by a micropore to obtain a target product BLUSH Ol oectif.
10. A method for preparing an anti-allergy and soothing base formula enriched in yeast broth Supferm PO according to any of claims 1 to 9, comprising the following steps:
step 1: dispersing part of the thickening agent by part of the emollient, adding the emulsifier, and homogenizing at a high speed, wherein the homogenizing force is 3000-8000 r/min, and the homogenizing time is 3-10 min to obtain a component A;
and 2, step: mixing powder and an emollient, homogenizing and dispersing with the homogenizing force of 3000-8000 r/min and the homogenizing time of 3-10 min to obtain a component B;
and step 3: uniformly mixing the component A and the component B to obtain a component C;
and 4, step 4: sequentially adding a film forming agent, an anti-allergy soothing agent and a part of conditioner into the component C, and homogenizing at a low speed, wherein the homogenizing force is 3000-8000 r/min, and the homogenizing time is 3-10 min to obtain a component D;
and 5: heating the preservative and the humectant to 60-85 ℃ under the condition of heat preservation, stirring for 5-10 min until the preservative and the humectant are dissolved, adding part of the thickener for dispersion, then adding part of the conditioner and the yeast fermentation liquor, dissolving, and homogenizing at a low speed, wherein the homogenizing force is 3000-8000 r/min, and the homogenizing time is 3-10 min, so as to obtain a component E;
step 6: slowly adding the component E into the component D in a stirring state at the speed of 400-500 r/min by using a stirrer, and homogenizing the component D by using a homogenizer at the homogenizing force of 3000-8000 r/min for 3-10 min after the component E is added; and stirring at the speed of 500-700 r/min for 3-5 min after homogenizing to obtain the target base makeup formula.
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