CN115006460B - Traditional Chinese medicine composition for dispelling effects of alcohol and protecting liver as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for dispelling effects of alcohol and protecting liver as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for dispelling the effects of alcohol and protecting liver, and a preparation method and application thereof, and relates to the fields of traditional Chinese medicines and health-care foods. The composition of the invention comprises a traditional Chinese medicine extract, vitamin B, vitamin C, erythritol and sucralose, wherein the traditional Chinese medicine extract comprises Cordyceps militaris, flos puerariae lobatae, semen hoveniae, chrysanthemum, silybum marianum, dark plum, mulberry leaf, dried orange peel and honeysuckle. The invention is prepared by reasonably proportioning the materials with homology of medicine and food, and the composition has the functions of dispelling the effects of alcohol and protecting liver through the synergistic effect of the components.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines and health-care foods, in particular to a traditional Chinese medicine composition for dispelling the effects of alcohol and protecting liver as well as a preparation method and application thereof.
Background
The liver is mainly used for organs of human metabolism, and toxic substances, toxins and metabolism and decomposition products of medicaments which are exotic and harmful wastes generated in the human metabolism process are detoxified in the liver. The liver is the largest reticuloendothelial phagocytic system, and can engulf, sequester and eliminate various antigens invading and endogenous, and meanwhile, almost all coagulation factors are produced by the liver, and the liver plays an important role in regulating the dynamic balance of two systems, namely human coagulation and anticoagulation.
The liver is a main organ for metabolizing alcohol, but the metabolism process of the liver causes irreparable damage to the liver, and long-term drinking of the liver can damage liver cell membranes and cause the liver cells to swell, necrose and the like. Alcohol is the first factor causing liver injury, long-term drinking causes adipogenesis of the liver, cannot be metabolized in liver cells, and is increasingly accumulated into alcoholic fatty liver; during the process of alcohol metabolism, the generated metabolites, ethanol and metabolic derivatives can cause inflammatory reaction to the liver, and the inflammation causes damage to liver cells and even necrosis, thereby leading to alcoholic hepatitis; if the damage to fatty liver and alcoholic hepatitis is not controlled in time, the damage can develop, then the damage can gradually develop into nodules, fibroplasia and liver fibrosis, and finally liver cirrhosis occurs, and finally liver cancer is formed.
The traditional Chinese medicine considers that alcoholism is caused by excessive drinking by external factors, and is caused by weakness of spleen and stomach, abnormal operation capability, alcoholic damp-heat and spleen and stomach imbalance by internal factors. The general treatment principle of the traditional Chinese medicine treatment method is that the traditional Chinese medicine treatment method treats both principal and secondary aspect of disease: in the early stage, alcohol dispelling and sweating and diuresis are the main treatment methods. The principle of "eliminating dampness by upper and lower parts" is proposed by Li Donghuan of one of four families of Jinyuan, which considers that "what is known as strong heat and toxic, smell is strong, and what is known as intangible, if injury occurs, the most wonderful method is to stop the heat and sweat, and secondly, the principle is to eliminate dampness by upper and lower parts, what is known as what is the wine disease? The middle stage disease is caused by the damage of spleen and stomach to liver and gallbladder, and this stage treatment is mainly to treat the disease and takes into account the healthy qi of the human body.
The prior anti-hangover medicine mainly comprises chemical medicines, traditional Chinese medicine preparations, health care products and the like. Although the chemical and the traditional Chinese medicine preparation take effect, the chemical and the traditional Chinese medicine preparation can generate great side effects on liver, kidney and the like, and the health care product produced by the raw materials with homology of medicine and food basically does not generate side effects on human bodies, and can realize quick alcohol effect under the condition of reasonable formula.
Disclosure of Invention
Aiming at the prior art, the invention aims to provide a traditional Chinese medicine composition for dispelling the effects of alcohol and protecting liver as well as a preparation method and application thereof. The composition has effects of relieving hangover and protecting liver.
In order to achieve the above purpose, the invention adopts the following technical scheme:
the invention provides a traditional Chinese medicine composition for dispelling effects of alcohol and protecting liver, and a preparation method and application thereof, wherein the composition comprises the following raw materials in parts by weight: 60-80 parts of traditional Chinese medicine extract, 0.003-0.006 part of vitamin B, 6-10 parts of vitamin C, 18-24 parts of erythritol and 0.001-0.01 part of trichlorosugar alcohol.
Preferably, the composition comprises the following raw materials in parts by weight: 65-75 parts of traditional Chinese medicine extract, 0.0036-0.0054 part of vitamin B, 7-9 parts of vitamin C, 19-22 parts of erythritol and 0.003-0.007 part of trichlorosugar alcohol.
The traditional Chinese medicine extract consists of the following raw materials in parts by weight: 5 to 8 parts of cordyceps militaris, 12 to 15 parts of flos puerariae lobatae, 12 to 15 parts of semen hoveniae, 12 to 15 parts of chrysanthemum, 12 to 15 parts of silybum marianum, 8 to 12 parts of dark plum, 8 to 12 parts of mulberry leaf, 8 to 12 parts of dried orange peel and 8 to 12 parts of honeysuckle.
Preferably, the traditional Chinese medicine extract bag comprises the following raw materials in parts by weight: 6-7 parts of cordyceps militaris, 13-14 parts of flos puerariae lobatae, 13-14 parts of semen hoveniae, 13-14 parts of chrysanthemum, 13-14 parts of silybum marianum, 9-11 parts of dark plum, 9-11 parts of mulberry leaf, 9-11 parts of dried orange peel and 9-11 parts of honeysuckle.
In the anti-alcoholic beverage, various raw material medicines contain active ingredients beneficial to anti-alcoholic, and after reasonable compatibility, the active ingredients produce a synergistic effect, so that the anti-alcoholic beverage can be used for rapidly and effectively dispelling the effects of alcohol. Wherein:
the Cordyceps militaris (Cordyceps militaris (L.ex Fr.) Link) belongs to Cordyceps genus of Clavipitaceae family, and also called Cordyceps militaris, cordyceps militaris. Cordyceps militaris contains Cordyceps polysaccharide, cordycepin, cordycepic acid, proteins, amino acids, superoxide dismutase, etc. Has uric acid reducing, tumor inhibiting, antiviral, antioxidant, liver function improving, immunity regulating, sexual function protecting, and radioprotective effects.
The flos Puerariae Lobatae is dried flower of Pueraria lobata (willd.) Ohwi of Leguminosae, is rich in volatile oil, and contains quercetin, ge Huadai, triterpene saponin, beta-sitosterol, flos Puerariae Lobatae isoflavone, etc. The Chinese medicine considers that the flos puerariae lobatae has the functions of dispelling the effects of alcohol, activating spleen, clearing heat, detoxicating, protecting liver, nourishing skin, tonifying kidney and the like, and is used for treating the symptoms of excessive drinking, headache, dizziness, polydipsia, chest and diaphragm fullness, acid regurgitation and other gastric qi injuries. Modern researches suggest that saponin and isoflavone contained in flos Puerariae Lobatae have oxidation-reduction effect, and can accelerate oxidation of alcohol to make alcohol lose toxicity, shrink and protect gastrointestinal mucosa, slow absorption of alcohol, and prevent alcohol from rapidly entering blood circulation, thereby improving metabolism abnormality caused by alcohol. Has effects in relieving hangover, activating spleen, clearing away heat and toxic materials, protecting liver, caring skin, and invigorating kidney, and can be used for treating excessive drinking, headache, dizziness, polydipsia, fullness in chest and diaphragm, and gastric qi injury such as emesis.
The semen Hoveniae is fruit of Hovenia dulcis Thunb (Hovenia acerba lindi.) of Hovenia of Rhamnaceae, and is rich in glucose, potassium nitrate and potassium malate; the seeds contain loline, hovenin C, D, G, G' and H. In traditional Chinese medicine, the fruits and seeds can be used as medicines, and have the effects of clearing heat, promoting urination and dispelling alcohol toxicity; the glucose and organic acid contained in the beverage can not only expand blood volume of human body, but also relieve alcoholism, and has the effects of sobering up and tranquillizing. Modern researches have found that hovenia dulcis thunb can significantly reduce the concentration of ethanol in blood and promote the removal of ethanol.
The chrysanthemum has the effects of dispelling wind, clearing heat, improving eyesight and detoxifying, and is mainly used for treating headache, dizziness, conjunctival congestion, dysphoria with smothery sensation in the chest, furuncle, toxic swelling and the like.
The silybum marianum is a silybum marianum plant of the Compositae, and can play a role in protecting liver, resisting oxidization, promoting regeneration of liver cells and the like, and is a flavonoid compound extracted from silybum marianum seeds, namely silymarin. The main components of the silymarin comprise silybin, silydianin and the like, wherein the silybin has the highest biological activity and the strongest liver protection effect. According to the research, the silybin has the effects of protecting and stabilizing liver cell membranes, promoting liver metabolism, resisting oxidization, diminishing inflammation, reducing blood fat and the like, so that the liver protecting effect can be achieved. The silybin has an antioxidant effect, and mainly protects liver cell membranes through lipid peroxidation. Its lipid-lowering effect is mainly due to the fact that silybin can lower triglyceride content in liver and serum total cholesterol level.
The mume fructus is black obtained by baking fructus mume of Rosaceae. Sour taste, mild nature, entering liver, lung, spleen and large intestine meridians. The efficacy of traditional dark plum is 3: 1. astringing with soreness, and treating various diseases with incoordination and inadvisable slip, such as chronic diarrhea, chronic cough, hemorrhage, etc., and chronic diarrhea, with fructus Chebulae, rhizoma Dioscoreae, atractylodis rhizoma, semen Myristicae, etc.; for treating chronic cough, lily, shizandra berry, aster and the like are combined; for hemorrhage, it is often combined with shan Hua Hu charcoal, yu Sanguisorba Di and ai Ye charcoal. 2. Promoting salivation to quench thirst, and treating thirst due to internal heat and fluid deficiency such as hyperthyroidism, diabetes insipidus, etc. 3. Dispelling ascariasis and alleviating pain, and treating ascariasis abdominal pain, it is combined with asarum herb, huang Lian, chuan Zanthoxylum, fu Zi and Huang Bai.
The mulberry leaf has the effects of clearing heat and detoxicating, removing stasis and detumescence, diminishing inflammation and dispelling alcohol, preventing and resisting cancer, improving the whole body blood flow state, enhancing the myocardial contraction capacity, and improving the blood pressure.
The dried orange peel belongs to bitter and pungent and warm. Enter lung and spleen meridians. Is effective in regulating qi-flowing, invigorating spleen, eliminating dampness and resolving phlegm. Can be used for treating abdominal distention, anorexia, vomiting and diarrhea, cough with excessive phlegm.
The honeysuckle has the effects of clearing heat and detoxicating, resisting inflammation, tonifying deficiency and treating wind, and has certain curative effect on dizziness, dry mouth, thirsty and other symptoms.
In the anti-alcoholic liver-protecting beverage, all raw materials are substances with homology of medicine and food, wherein cordyceps militaris plays a main role as a monarch drug, kudzuvine flower and hovenia dulcis seed play an auxiliary role as ministerial drugs, chrysanthemum, silybum marianum and dark plum play an auxiliary role as adjuvant drugs, and mulberry leaf, dried orange peel and honeysuckle play an auxiliary role as messenger drugs. The active ingredients contained in the raw materials complement each other and synergistically increase each other, so that the beverage for dispelling the effects of alcohol and protecting the liver can improve the activity of superoxide dismutase in the body, remove a large amount of oxygen free radicals which are prevented after alcoholism and are generated by cells, lighten the damage to the cells, protect the stability of cell membranes, promote the decomposition and metabolism of alcohol, and simultaneously remarkably reduce serum glutamic pyruvic transaminase and glutamic oxaloacetic transaminase level and repair pathological damage of the liver.
In the composition of the invention, the vitamin B comprises vitamin B 1 Vitamin B 2 Vitamin B 6 The weight portions are as follows: 0.001-0.002 parts, 0.001-0.002 parts.
Preferably, the weight parts of vitamin B1, vitamin B2 and vitamin B6 are as follows: 0.0012 to 0.0018 part, 0.0012 to 0.0018 part and 0.0012 to 0.0018 part.
The vitamin B can be used as a synthetic raw material of organism reaction enzyme, can improve metabolism of fatty protein, promote digestion, and participate in the actions of various proteases in the body and various metabolic reactions in the body. Sufficient B vitamins can avoid liver fatty degeneration, improve the tolerance of liver to ethanol, eliminate endotoxin such as ethanol and tobacco tar, protect liver, thereby having the effects of preventing fatty liver and nourishing liver.
In the composition, the mass percentage of the vitamin C is 6-10 parts of the vitamin C, and preferably 7-9 parts of the vitamin C.
The vitamin C is a strong reducing agent, and can protect other antioxidants, prevent free radicals from damaging human bodies, protect cells, detoxify and protect livers. It also promotes the conversion of the oxidation form of many in vivo antioxidant enzymes to the reduction form, thereby continuously exerting antioxidant effect.
The invention has the beneficial effects that:
the invention is prepared by reasonably proportioning the materials with homology of medicine and food, and the composition has the functions of dispelling the effects of alcohol and protecting liver through the synergistic effect of the components.
Detailed Description
It should be noted that the following detailed description is illustrative and is intended to provide further explanation of the present application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
In order to enable those skilled in the art to more clearly understand the technical solutions of the present application, the technical solutions of the present application will be described in detail below with reference to specific embodiments.
The test materials used in the examples of the present invention are all conventional in the art and are commercially available.
Example 1:
the preparation of the anti-alcohol liver-protecting composition comprises the following steps:
(1) Chinese medicinal composition
The traditional Chinese medicine extract disclosed by the invention consists of the following raw material medicines: 6.5 parts of cordyceps militaris, 13.5 parts of flos puerariae lobatae, 13.5 parts of semen hoveniae, 13.5 parts of chrysanthemum, 13.5 parts of silybum marianum, 10 parts of dark plum, 10 parts of mulberry leaf, 10 parts of dried orange peel and 10 parts of honeysuckle.
(2) Extraction of Chinese medicinal materials
Mixing the above Chinese medicinal materials, placing into an extraction tank, adding purified water 10 times the weight of the Chinese medicinal materials, soaking for 1 hr, heating to boil, keeping micro-boiling for 1 hr, and collecting extractive solution; adding water into the filter residue for 8 times, heating to boil, keeping micro boiling for 1 hour, collecting the extracting solution, combining the extracting solutions, centrifuging at high speed and 10000 revolutions per minute, removing the fine filter residue, concentrating the centrifugate in vacuum to obtain extract with the solid content of about 20%, vacuum drying the extract, and controlling the temperature to 80-90 ℃ to obtain an extract block; pulverizing the extract block, and sieving with 60 mesh sieve to obtain the traditional Chinese medicine extract.
(3) Preparation of the composition
Weighing: weighing 60 parts of traditional Chinese medicine extract and vitamin B 1 0.001 part of vitamin B 2 0.001 part of vitamin B 6 0.001 part, vitamin C6 part, erythritol 18 part and sucralose 0.001 part.
Total mixing: and (3) putting the weighed raw materials into a three-dimensional mixer for uniform mixing to obtain the composition.
Example 2:
the preparation of the anti-alcohol liver-protecting composition comprises the following steps:
(1) Chinese medicinal composition
The traditional Chinese medicine extract disclosed by the invention consists of the following raw material medicines: 5 parts of cordyceps militaris, 12 parts of kudzuvine flower, 12 parts of hovenia dulcis thunb, 12 parts of chrysanthemum, 12 parts of silybum marianum, 8 parts of dark plum, 8 parts of mulberry leaf, 8 parts of dried orange peel and 8 parts of honeysuckle.
(2) Extraction of Chinese medicinal materials
Mixing the above Chinese medicinal materials, placing into an extraction tank, adding purified water 10 times the weight of the Chinese medicinal materials, soaking for 1 hr, heating to boil, keeping micro-boiling for 1 hr, and collecting extractive solution; adding water into the filter residue for 8 times, heating to boil, keeping micro boiling for 1 hour, collecting the extracting solution, combining the extracting solutions, centrifuging at high speed and 10000 revolutions per minute, removing the fine filter residue, concentrating the centrifugate in vacuum to obtain extract with the solid content of about 20%, vacuum drying the extract, and controlling the temperature to 80-90 ℃ to obtain an extract block; pulverizing the extract block, and sieving with 60 mesh sieve to obtain the traditional Chinese medicine extract.
(3) Preparation of the composition
Weighing: weighing 60 parts of traditional Chinese medicine extract and vitamin B 1 0.001 part of vitamin B 2 0.001 part of vitamin B 6 0.001 part, vitamin C6 part, erythritol 18 part and sucralose 0.001 part.
Total mixing: and (3) putting the weighed raw materials into a three-dimensional mixer for uniform mixing to obtain the composition.
Example 3:
the preparation of the anti-alcohol liver-protecting composition comprises the following steps:
(1) Chinese medicinal composition
The traditional Chinese medicine extract disclosed by the invention consists of the following raw material medicines: 8 parts of cordyceps militaris, 15 parts of kudzuvine flower, 15 parts of hovenia dulcis thunb, 15 parts of chrysanthemum, 15 parts of silybum marianum, 12 parts of dark plum, 12 parts of mulberry leaf, 12 parts of dried orange peel and 12 parts of honeysuckle.
(2) Extraction of Chinese medicinal materials
Mixing the above Chinese medicinal materials, placing into an extraction tank, adding purified water 10 times the weight of the Chinese medicinal materials, soaking for 1 hr, heating to boil, keeping micro-boiling for 1 hr, and collecting extractive solution; adding water into the filter residue for 8 times, heating to boil, keeping micro boiling for 1 hour, collecting the extracting solution, combining the extracting solutions, centrifuging at high speed and 10000 revolutions per minute, removing the fine filter residue, concentrating the centrifugate in vacuum to obtain extract with the solid content of about 20%, vacuum drying the extract, and controlling the temperature to 80-90 ℃ to obtain an extract block; pulverizing the extract block, and sieving with 60 mesh sieve to obtain the traditional Chinese medicine extract.
(3) Preparation of the composition
Weighing: weighing 80 parts of traditional Chinese medicine extract and vitamin B 1 0.002 parts of vitamin B 2 0.002 parts of vitamin B 6 0.002 parts, vitamin C10 parts, erythritol 24 parts and sucralose 0.01 parts.
Total mixing: and (3) putting the weighed raw materials into a three-dimensional mixer for uniform mixing to obtain the composition.
Comparative example 1:
the preparation of the anti-alcohol liver-protecting composition comprises the following steps:
(1) Traditional Chinese medicine weighing
100 parts of cordyceps militaris are weighed.
(2) Extraction of Chinese medicinal materials
Placing the weighed Cordyceps militaris in an extraction tank, adding purified water 10 times the weight of the Chinese medicinal materials, soaking for 1 hr, heating to boil, keeping micro-boiling for 1 hr, and collecting extractive solution; adding water into the filter residue for 8 times, heating to boil, keeping micro boiling for 1 hour, collecting the extracting solution, combining the extracting solutions, centrifuging at high speed and 10000 revolutions per minute, removing the fine filter residue, concentrating the centrifugate in vacuum to obtain extract with the solid content of about 20%, vacuum drying the extract, and controlling the temperature to 80-90 ℃ to obtain an extract block; pulverizing the extract block, and sieving with 60 mesh sieve to obtain the traditional Chinese medicine extract.
(3) Preparation of the composition
Weighing: weighing 70 parts of traditional Chinese medicine extract and vitamin B 1 0.0015 part of vitamin B 2 0.0015 part of vitamin B 6 0.0015 part, 8.3 parts of vitamin C, 21.69 parts of erythritol and 0.0055 part of sucralose.
Total mixing: and (3) putting the weighed raw materials into a three-dimensional mixer for uniform mixing to obtain the composition.
Comparative example 2:
the preparation of the anti-alcohol liver-protecting composition comprises the following steps:
(1) Chinese medicinal composition
Weighing 50 parts of flos puerariae lobatae and 50 parts of semen hoveniae.
(2) Extraction of Chinese medicinal materials
Mixing the above Chinese medicinal materials, placing into an extraction tank, adding purified water 10 times the weight of the Chinese medicinal materials, soaking for 1 hr, heating to boil, keeping micro-boiling for 1 hr, and collecting extractive solution; adding water into the filter residue for 8 times, heating to boil, keeping micro boiling for 1 hour, collecting the extracting solution, combining the extracting solutions, centrifuging at high speed and 10000 revolutions per minute, removing the fine filter residue, concentrating the centrifugate in vacuum to obtain extract with the solid content of about 20%, vacuum drying the extract, and controlling the temperature to 80-90 ℃ to obtain an extract block; pulverizing the extract block, and sieving with 60 mesh sieve to obtain the traditional Chinese medicine extract.
(3) Preparation of the composition
Weighing: weighing 70 parts of traditional Chinese medicine extract and vitamin B 1 0.0015 part of vitamin B 2 0.0015 part of vitamin B 6 0.0015 part, 8.3 parts of vitamin C, 21.69 parts of erythritol and 0.0055 part of sucralose.
Total mixing: and (3) putting the weighed raw materials into a three-dimensional mixer for uniform mixing to obtain the composition.
Comparative example 3:
the preparation of the anti-alcohol liver-protecting composition comprises the following steps:
(1) Weighing Chinese medicinal materials
Weighing 37.5 parts of chrysanthemum, 37.5 parts of silybum marianum and 25 parts of dark plum.
(2) Extraction of Chinese medicinal materials
Mixing the above Chinese medicinal materials, placing into an extraction tank, adding purified water 10 times the weight of the Chinese medicinal materials, soaking for 1 hr, heating to boil, keeping micro-boiling for 1 hr, and collecting extractive solution; adding water into the filter residue for 8 times, heating to boil, keeping micro boiling for 1 hour, collecting the extracting solution, combining the extracting solutions, centrifuging at high speed and 10000 revolutions per minute, removing the fine filter residue, concentrating the centrifugate in vacuum to obtain extract with the solid content of about 20%, vacuum drying the extract, and controlling the temperature to 80-90 ℃ to obtain an extract block; pulverizing the extract block, and sieving with 60 mesh sieve to obtain the traditional Chinese medicine extract.
(3) Preparation of the composition
Weighing: weighing 70 parts of traditional Chinese medicine extract and vitamin B 1 0.0015 part of vitamin B 2 0.0015 part of vitamin B 6 0.0015 part, 8.3 parts of vitamin C, 21.69 parts of erythritol and 0.0055 part of sucralose.
Total mixing: and (3) putting the weighed raw materials into a three-dimensional mixer for uniform mixing to obtain the composition.
Comparative example 4:
the preparation of the anti-alcohol liver-protecting composition comprises the following steps:
(1) Weighing Chinese medicinal materials
33 parts of mulberry leaf, 33 parts of dried orange peel and 34 parts of honeysuckle are weighed.
(2) Extraction of Chinese medicinal materials
Mixing the above Chinese medicinal materials, placing into an extraction tank, adding purified water 10 times the weight of the Chinese medicinal materials, soaking for 1 hr, heating to boil, keeping micro-boiling for 1 hr, and collecting extractive solution; adding water into the filter residue for 8 times, heating to boil, keeping micro boiling for 1 hour, collecting the extracting solution, combining the extracting solutions, centrifuging at high speed and 10000 revolutions per minute, removing the fine filter residue, concentrating the centrifugate in vacuum to obtain extract with the solid content of about 20%, vacuum drying the extract, and controlling the temperature to 80-90 ℃ to obtain an extract block; pulverizing the extract block, and sieving with 60 mesh sieve to obtain the traditional Chinese medicine extract.
(3) Preparation of the composition
Weighing: weighing 70 parts of traditional Chinese medicine extract and vitamin B 1 0.0015 part of vitamin B 2 0.0015 part of vitamin B 6 0.0015 part, 8.3 parts of vitamin C, 21.69 parts of erythritol and 0.0055 part of sucralose.
Total mixing: and (3) putting the weighed raw materials into a three-dimensional mixer for uniform mixing to obtain the composition.
Test example 1:
the beverage prepared by adding water to the anti-hangover and liver-protecting compositions obtained in example 1, comparative example 2, comparative example 3 and comparative example 4 was subjected to a mouse anti-hangover test.
60 mice (half of each female and male mice, each group has mass error of not more than 10 g) are taken, and the mice are fasted and forbidden late before the experiment. Mice were fed with 0.15 ml/(10 kg body weight) of white spirit, and drunk mice were randomly divided into 6 groups of 10 mice each, and the control group was fed with 0.25 ml/(10 g body weight) of physiological saline, and the other 5 groups were fed with 0.25 ml/(10 g body weight) of the beverages prepared in example 1 and comparative examples 1 to 4, respectively. And (5) observing the sobering-up condition of the mice.
Recording the time (min) for the disappearance of the drunk symptoms by using the eversion and the reflection as the indexes
TABLE 1 drunk time of mice of each group
P < 0.05, p < 0.01 compared to control group
The above-mentioned mouse sobering-up experiment refers to an anti-hangover beverage anti-hangover effect experiment in Chinese patent document CN108271963A (application No. 201810365814.3).
As can be seen from the above table, there was a significant difference in sober-up in mice compared to the control group. The anti-alcoholic beverage can shorten the drunk time of mice and has better drunk effect. Meanwhile, the effect of rapidly dispelling the effects of alcohol can be exerted under the synergistic effect of the principal drug, the ministerial drug, the adjuvant drug and the conductant drug.
Test example 2:
the beverage prepared by adding water to the anti-hangover and liver-protecting compositions obtained in example 1, comparative example 2, comparative example 3 and comparative example 4 was subjected to a mouse anti-hangover test.
60 mice (half of each female and male mice, each group has mass error of not more than 10 g) are taken, and the mice are fasted and forbidden late before the experiment. Mice were randomly divided into 6 groups of 10 mice each, wherein the control group was filled with 0.3ml of physiological saline per day, 0.3ml of white spirit after 30min, and the other 5 groups were each filled with 0.3ml of the compositions of example 1 and comparative examples 1 to 4, and 0.3ml of white spirit after 30 min. Each group of mice was continuously perfused with stomach for 5 weeks. After the last day of gastric lavage is finished for 30min, separating serum from blood of the small ball eyeballs, and measuring the activity of ALT and AST in the serum of each group of mice according to the specification of the glutamic pyruvic transaminase (ALT) test kit and the dark oxaloacetic transaminase (AST) test kit by using a spectrophotometer. The data are shown in table 1.
After eyeball blood is collected from each group of mice, dissecting, taking out liver, accurately weighing the liver mass, removing a proper amount of liver tissue, taking 0.9% physiological saline as a homogenate medium, preparing 10% liver homogenate, centrifuging, taking supernatant, and detecting Glutamic Pyruvic Transaminase (GPT) for later use.
(the above mouse experiment refers to the functional test in Chinese patent document CN108271963A (application No. 202011407436.4)
Liver index = liver mass/body weight x 100%.
The level of GPT in the liver homogenate of mice was determined according to the GPT kit instructions and the data are shown in table 2.
TABLE 2 statistical results of serum ALT and AST activities of mice of each group
| Group of | ALT (Kamen's unit) | AST (Kamen's unit) |
| Example 1 | 31.12±1.76 | 32.56±1.27 |
| Comparative example 1 | 49.52±2.74 | 57.76±1.78 |
| Comparative example 2 | 52.07±1.23 | 60.29±2.87 |
| Comparative example 3 | 55.12±2.11 | 65.73±1.27 |
| Comparative example 4 | 56.72±1.98 | 69.27±2.01 |
| Control group | 58.49±3.17 | 72.59±1.08 |
TABLE 3 liver index and liver tissue GSH-Px Activity for mice of each group
| Group of | Liver index/% | GPT/U.mg-1 protein |
| Example 1 | 3.37±1.28 | 112.57±1.23 |
| Comparative example 1 | 4.93±1.21 | 165.15±1.02 |
| Comparative example 2 | 5.71±1.83 | 168.23±1.72 |
| Comparative example 3 | 6.21±1.08 | 173.27±2.35 |
| Comparative example 4 | 6.61±1.15 | 176.82±1.91 |
| Control group | 7.03±1.02 | 186.13±4.58 |
As can be seen from the data in Table 1, both the products of example 1 and comparative examples 1-4 effectively reduced ALT and AST, but it is evident that the magnitude of ALT and AST reduction in example 1 is greater than that in comparative examples 1-4, mainly because the composition of the present invention has various antioxidant components, has excellent antioxidant ability, can raise superoxide dismutase activity in vivo, scavenge a large amount of oxygen free radicals generated by tissues and cells after alcoholism, reduce damage to cells, protect cell membranes from stability, and promote decomposition and metabolism of alcohol.
According to the data in Table 2, the anti-alcoholic liver-protecting drink can obviously reduce the serum glutamic-pyruvic transaminase and glutamic-oxaloacetic transaminase levels and repair the pathological damage of the liver.
Meanwhile, the effect of rapidly protecting liver can be achieved under the synergistic effect of the principal drug, the ministerial drug, the adjuvant drug and the conductant drug.
Test example 3:
the anti-hangover and liver-protecting composition prepared in example 1 was subjected to a human efficacy test.
The efficacy of the anti-hangover and liver-protecting beverage in example 1 was observed by taking 2 bags of the beverage after drinking, which was frequently taken by a large number of drunk volunteers.
Table 4 clinical symptoms efficacy manifestation
| Number of examples | Has obvious effect | Effective and effective | Invalidation of | Total effective rate |
| 34 | 14 | 18 | 2 | 94.12％ |
Wherein, the efficacy standard is:
the effect is shown: the clinical symptoms such as nausea, vomiting, dizziness, headache, palpitation, hypodynamia and the like disappear, or the symptoms are not obvious, but the pain is not obvious;
the method is effective: the clinical symptoms such as nausea, vomiting, dizziness, headache, palpitation, hypodynamia and the like are obviously improved, and certain pain is felt, but the symptoms can be tolerated;
invalidation: the clinical symptoms are not improved, and the patients feel extremely painful and cannot be tolerated.
Total effective rate = (effective + effective) number of cases/total number of cases x 100%
The foregoing description is only of the preferred embodiments of the present application and is not intended to limit the same, but rather, various modifications and variations may be made by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.
Claims (2)
1. The composition is characterized by comprising the following raw materials in parts by weight: 60-80 parts of traditional Chinese medicine extract, 0.003-0.006 part of vitamin B, 6-10 parts of vitamin C, 18-24 parts of erythritol and 0.001-0.01 part of sucralose;
the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 5 to 8 parts of cordyceps militaris, 12 to 15 parts of flos puerariae lobatae, 12 to 15 parts of semen hoveniae, 12 to 15 parts of chrysanthemum, 12 to 15 parts of silybum marianum, 8 to 12 parts of dark plum, 8 to 12 parts of mulberry leaf, 8 to 12 parts of dried orange peel and 8 to 12 parts of honeysuckle;
the vitamin B consists of the following raw materials in parts by weight: 0.001-0.002 parts of vitamin B1, 0.001-0.002 parts of vitamin B2 and 0.001-0.002 parts of vitamin B6;
the composition for dispelling the effects of alcohol and protecting liver is prepared by the following method:
(1) Mixing Cordyceps militaris, flos Puerariae Lobatae, semen Hoveniae, flos Chrysanthemi, herba Silybi Mariani, mume fructus, folium Mori, pericarpium Citri Tangerinae and flos Lonicerae at a certain weight ratio, soaking in purified water, heating to obtain extractive solution, centrifuging to obtain centrifugate, vacuum-compressing the centrifugate to obtain extract, vacuum-drying, pulverizing, and sieving to obtain Chinese medicinal extract;
(2) Mixing the Chinese medicinal extract, vitamin B1, vitamin B2, vitamin B6, vitamin C, erythritol and sucralose according to weight ratio.
2. Use of the anti-hangover and liver-protecting composition of claim 1 in the preparation of an anti-hangover and liver-protecting product.
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