CN114990202A

CN114990202A - Application of SNP (Single nucleotide polymorphism) locus in evaluation of genome abnormality and method for evaluating genome abnormality

Info

Publication number: CN114990202A
Application number: CN202210903055.8A
Authority: CN
Inventors: 季序我; 李哲; 朱晓茹; 吕然
Original assignee: Beijing Pukang Ruiren Medical Laboratory Co ltd; Predatum Biomedicine Suzhou Co ltd; Precision Scientific Technology Beijing Co ltd
Current assignee: Beijing Pukang Ruiren Medical Laboratory Co ltd; Predatum Biomedicine Suzhou Co ltd; Precision Scientific Technology Beijing Co ltd
Priority date: 2022-07-29
Filing date: 2022-07-29
Publication date: 2022-09-02
Anticipated expiration: 2042-07-29
Also published as: CN114990202B

Abstract

The invention discloses application of SNP loci in evaluating genome abnormality and a method for evaluating genome abnormality. The SNP loci are biallelic high polymorphic loci which are approximately and uniformly distributed on a chromosome, and the minimum allele frequency of each SNP locus is distributed between 0.05 and 0.5; the density of each SNP site on the genome is 16.5 per million genome bases; the GC content of 250-350 nucleotides taking each SNP locus as the center is 40-60 percent; and each SNP site accords with the Hardy-Winberg equilibrium law and simultaneously satisfies the condition that the differentiation coefficient of the population is lower than 0.05. The genome anomaly evaluation result obtained by adopting the technical scheme provided by the invention has higher precision, can discover more and more comprehensive genome anomaly conditions, can process the genome anomaly condition with unchanged chromosome structure, is more suitable for Chinese people, and is more accurate.

Description

Application of SNP (Single nucleotide polymorphism) locus in evaluation of genome abnormality and method for evaluating genome abnormality

Technical Field

The invention relates to the technical field of biology, in particular to application of SNP loci in evaluating genome abnormality and a method for evaluating genome abnormality.

Background

At present, the common methods for evaluating genomic abnormalities mainly include the following methods:

pathology-based and stain-based karyotyping methods. In this method, the chromosome morphology can be directly observed under a microscope to evaluate whether the chromosome is different from the normal state. The method can only observe specific abnormal phenomena in a large range, and has insufficient precision. For example, only the deletion of the entire chromosome broken arm can be seen. Furthermore, abnormalities in which the chromosome structure is not changed, such as a case where the structure of a certain chromosome is not changed but there are two paternal chromosomes and no maternally chromosomes, cannot be observed.

A digital karyotype analysis method based on whole genome sequencing. The method does not need dyeing, and compares the sequencing fragment with a reference genome through whole genome sequencing and biological information analysis to evaluate whether the genome region is uncovered or excessively covered so as to judge whether the chromosome is abnormal. This method has improved accuracy, but cannot deal with the above-mentioned abnormal cases in which the chromosome structure is not changed.

Methods for detecting loss of heterozygosity (LOH). The method judges whether the locus is homozygous or heterozygous by selecting the locus, thereby judging whether the LOH appears in the genome region of the sample. The method can detect the abnormal condition of the invariant chromosome structure, and the accuracy of detecting the genome abnormality can reach 1.5 million bases and above. However, the detection accuracy for a specific population such as Chinese is low.

Pathogenic mutation detection of BRCA1 and BRCA2 genes is adopted to indirectly judge whether tumor cells have genome abnormality. It is believed that pathogenic mutations in BRCA1 and/or BRCA2 genes result in genomic abnormalities, and thus may be used. However, not all genomic abnormalities of tumor cells are caused by pathogenic mutations in the BRCA1 and BRCA2 genes. In addition, many of the genomic abnormalities of tumor cells are associated with germline and systemic mutations in HRR genes other than BRCA1 and BRCA2, and some of the tumor cells are associated with other factors such as methylation of specific gene promoters, unknown biological factors, and the like.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides the following technical scheme.

The first aspect of the invention provides the application of a group of SNP sites in evaluating genome abnormality or preparing a device for evaluating genome abnormality, wherein the SNP sites are biallelic high polymorphic sites which are approximately and uniformly distributed on a chromosome, and the group minimum allele frequency of each SNP site is distributed between 0.05 and 0.5; the density of each SNP site on the genome is 16.5 per million genome bases; the GC content of 250-350 nucleotides taking each SNP locus as the center is 40-60 percent; and each SNP locus conforms to the Hardy-Winberg equilibrium law and simultaneously satisfies the condition that the group differentiation coefficient is lower than 0.05.

In a second aspect, the present invention provides a method for assessing genomic abnormalities, comprising:

selecting a plurality of SNP sites according to the first aspect, and constructing a capture probe or a kit capable of capturing nucleotide fragments containing the SNP sites;

extracting DNA of a detection sample;

constructing a detection sample DNA library;

hybridizing the capture probe or the capture probe in the kit with the DNA library for capture and sequencing;

performing bioinformatics analysis on the sequencing result to obtain the sequencing fragment ratio corresponding to each heterozygous SNP locus;

calculating a genome abnormal index based on the sequencing fragment ratio corresponding to the heterozygous SNP locus;

and quantitatively evaluating the genome abnormality according to the genome abnormality index.

Preferably, the obtaining of the ratio of the sequencing fragments corresponding to each heterozygous SNP site comprises:

acquiring the number of each allele of the heterozygous SNP locus and the total number of all alleles;

the ratio of each allele is calculated using the number of each allele and the total number of all alleles.

Preferably, the genomic abnormality indicator includes: LOH, TAI and LST, wherein LOH is the copy number of a secondary allele in a segment is 0, the copy number of a main allele is not 0, and the length of the segment is more than 15M; TAI is initiated from telomere and does not cross the centromere, the fragment length is greater than 11M; the LST is a case where the lengths of two adjacent segments are greater than 10M after deleting segments shorter than 3M.

Preferably, the calculating of the genomic abnormality index based on the ratio of the sequenced fragments corresponding to the heterozygous SNP site comprises:

detecting heterozygous SNP sites located on the same chromosome arm, and classifying the adjacent heterozygous SNP sites into the same segment if the rank and the detection P value of the adjacent heterozygous SNP sites are greater than a threshold value, so as to realize the segmentation of the genome;

and obtaining the optimal tumor purity, ploidy and copy number information by adopting a probabilistic model parameter estimation method according to the depth and the sub-allele frequency of each segment, and calculating LOH, TAI and LST of the genome according to the information and the segment information.

In a third aspect, the present invention provides a capture probe for assessing genomic abnormalities, said probe being useful for capturing nucleotide fragments comprising a plurality of SNP sites as described in the first aspect.

In a fourth aspect, the present invention provides a kit for assessing genomic abnormalities, which comprises at least one dose of the probe of the third aspect.

In a fifth aspect, the invention provides a probe according to the third aspect or a kit according to the fourth aspect for use in assessing genomic abnormalities.

In a sixth aspect, the invention provides the use of a probe according to the third aspect or a kit according to the fourth aspect in the manufacture of a product for assessing genomic abnormalities.

The invention has the beneficial effects that: compared with the staining-based karyotype analysis, the application of the SNP locus in the assessment of the genomic abnormality and the method for assessing the genomic abnormality have higher precision; compared with the method for indirectly judging the genome abnormality by detecting BRCA mutation, more and more comprehensive genome abnormality conditions can be found; compared with digital karyotyping based on whole genome sequencing, the method can treat the genomic abnormality with unchanged chromosome structure, such as the chromosome deletion from the female parent and the double copy of the male parent chromosome; compared with the current common method (such as Myriad company) for detecting loss of heterozygosity (LOH) in the market, the selected locus is more suitable for Chinese people, and the evaluation result is more accurate.

Drawings

FIG. 1 is a diagram illustrating the distribution of abnormal scores of genomes according to an embodiment of the present invention.

Detailed Description

In order to better understand the technical solution, the technical solution will be described in detail with reference to the drawings and the specific embodiments.

"genomic abnormality" is understood in its broadest sense to mean any change in the genomic sequence, such as a single nucleotide mutation, a structural variation, a methylation modification of a particular region, and the like. The genomic abnormality as referred to in the present invention refers to genomic instability, that is, a phenomenon of genomic scarring.

Example one

The embodiment of the invention provides application of the SNP locus in evaluating genome abnormality or preparing a product for evaluating genome abnormality. Wherein, the SNP loci can be selected according to the following method:

based on Single Nucleotide Polymorphism (SNP) locus data of Chinese population, biallelic high polymorphism loci distributed on chromosomes as uniformly as possible are selected.

First, the population minimum allele frequencies of these loci were all above 0.05, and ranged between 0.05-0.5. The density of sites on the genome is approximately 16.5/mega genome base so that abnormalities across the genome can be better assessed.

Secondly, for the subsequent acquisition of relatively balanced data between sites, the cytosine (C) and guanine (G) contents of the genomic region in which the site is located are restricted, for example, the GC content of 300 nucleotides centered on the SNP site is required to be 40-60%.

Again, to rule out significant genotyping errors, the SNP site is required to comply with the haddy-weinberg equilibrium law. Meanwhile, in order to reduce the influence of population differentiation degree among different domains, the SNP site needs to satisfy the population differentiation index (FST) lower than 0.05.

Thirdly, in order to improve the detection effect, more than 500 cases of actual detection data of clinical samples are adopted to screen the sequencing depth and the sequencing stability of the sites.

Finally, 51263 double-allele high-polymorphism sites of Chinese population are obtained.

Example two

The embodiment of the invention provides a method for evaluating genome abnormality, which comprises the following steps:

selecting a plurality of SNP sites, wherein the selected SNP sites and the selection method thereof can refer to the method provided by the first embodiment;

constructing a capture probe or a kit; wherein the capture probe can capture a nucleotide fragment containing a plurality of SNP sites as described in example one. The kit comprises at least one dose of the probe. The probe and the kit can be used for evaluating the genome abnormality and can also be used for preparing products for evaluating the genome abnormality.

Extracting DNA of a detection sample;

constructing a detection sample DNA library;

And quantitatively evaluating the genome abnormality according to the genome abnormality indexes.

In the above method, both the sample to be tested (e.g., solid tumor) and a control sample free of abnormalities (e.g., peripheral blood of a solid tumor patient) that can be used for comparison can be treated. If there is no control sample, only the test sample may be processed.

The detection process comprises an experiment part and a bioinformatics analysis part, wherein the experiment part can be implemented by adopting the following steps:

1. sample collection and reception

a. Fresh blood sample: the detection standard is EDTA anticoagulation 2 ml;

b. paraffin section sample: the detection standard is 5 μm thick and more than 1cm ² At least 6 pieces of surgical tissue and at least 10 pieces of puncture tissue;

c. fresh tissue samples: the tissues were placed in 10% formalin storage tubes and RNAlater storage tubes, respectively, for examination, with 1 tissue per tube being about the size of soybeans.

2. Tumor content assessment

The tumor tissue needs to be evaluated for the tumor content, and the qualified standard of the tumor content is more than or equal to 20 percent. If the tumor content is more than or equal to 10% and less than 20%, the risk detection can be carried out, and if the tumor content is less than 10%, the detection is stopped.

3. Sample DNA extraction and quality control

The DNA in the sample can be obtained using a DNA extraction kit (e.g., a DNA extraction kit dedicated to formalin-fixed paraffin-embedded samples, a whole blood DNA extraction kit) for the corresponding sample type.

The quality inspection of the sample DNA needs to meet the following requirements:

a. the total amount of DNA detected by the Qubit in blood or fresh tissue is more than or equal to 200ng, and the main band of the DNA detected by gel electrophoresis is more than or equal to 10 Kbp.

FFPE/wax block requires a total amount of DNA to satisfy a minimum initial pool building amount at a time.

4. Library construction

The library is obtained by DNA fragmentation, end repair and adenine (A) addition, adaptor fragment ligation, amplification steps. The concentration of the constructed library is more than or equal to 0.5 ng/mu l.

5. And (3) utilizing the capture probe or the capture probe in the kit to perform hybrid capture with the DNA library. And mixing the DNA library with the synthesized site capture probe, performing a hybridization capture experiment, and after the capture probe and the library are fully mixed, performing elution and purification steps to obtain a final operable sequencing library.

6. Sequencing on machine

Novaseq6000 is adopted as a sequencing platform, the machine-out sequencing quantity of the tumor tissue is 6G, and the machine-out sequencing quantity of the control sample is 2G.

The specific operation methods of all the steps are the same as those in the prior art, and are not described herein again.

The bioinformatics analysis section may be implemented by the following steps:

1. and the data analyst starts data analysis after receiving the data offline notification of the data manager.

2. And extracting the item number, the corresponding subject screening number and the corresponding data path according to a data docking table provided by a data administrator, and writing the item number, the corresponding subject screening number and the corresponding data path into a standard input format required by an automatic analysis process.

3. Starting a data analysis process, wherein software used in the process comprises the following steps: fastp (version 0.20.0), bwa (version 0.7.17-r 1198-dirty), samtools (version 1.9), gatk (version 4.2.2.0), bendaols (version v 2.30.0). The data analysis process is generally completed within 5-8 hours, and after the data analysis process is completed, the student believes that an analyst needs to check the analysis quality control result, wherein the quality control standard is shown in table 1. If the quality control is passed, a report analysis record is filled. If the analysis is interrupted or the quality control fails, the processing is required to be carried out in an exception handling mode.

Note: table 1 shows the sequencing data quality control standard. The sequence alignment quality of the control sample and the detection sample is higher than that of Q30, and the sequence alignment rate is higher than 90%. The average sequencing depth of the control sample is at least 50X, and the average sequencing depth of the test sample is at least 150X.

4. Exception handling: for example, the analysis interruption is first confirmed. If the analysis is interrupted due to external reasons, such as power failure of an external computer room, hardware failure and the like, analysis can be performed again according to the analysis flow after the failure is eliminated and the intermediate folder is renamed and analyzed. The original folder name is weighed and named as the original folder name-analysis times. If the quality control fails, the data administrator needs to be contacted to perform additional testing or retesting, and the analysis is restarted.

5. A report is generated.

And performing bioinformatics analysis on the sequencing result, comparing the sequencing fragments to a human genome, extracting the sequencing fragment information of 51263 sites, and recording the sequencing fragment ratio corresponding to each site. And selecting the heterozygous SNP locus for calculating the subsequent heterozygous deletion LOH, telomere imbalance TAI and large fragment displacement LST. Assuming that the SNP site i has two alleles A and B, the number of sequencing fragments corresponding to A is N, the number of sequencing fragments corresponding to B is M, calculating the ratio p of the sequencing fragments corresponding to A _i = N/(N + M), and the sequencing fragment ratio q corresponding to B _i = M/(N + M). Thus, data information of each heterozygous SNP site of the sample to be detected and the control sample is obtained. And then, segmenting the genome according to the sequencing fragment ratio corresponding to the SNP loci and the corresponding sequencing depth, specifically, detecting the heterozygous SNP loci positioned on the same chromosome arm, and classifying the adjacent heterozygous SNP loci into the same segment if the rank sum detection P value of the adjacent heterozygous SNP loci is greater than a threshold value (such as 0.001, 0.01, 0.05, 0.1 and the like), thereby realizing the segmentation of the genome. Then, according to the information of the depth, the sub-allele frequency and the like of each segment, a probability model parameter estimation method is adopted to estimate the optimal tumor purity and ploidy so as to obtain the optimal tumor purity and ploidy And copy number information. Then, based on the above segmentation information and the optimal tumor purity, ploidy, and copy number, LOH, TAI, and LST of the genome are calculated. Where LOH is defined as the copy number of the minor allele in the segment being 0, the copy number of the major allele being other than 0, and the length of the segment being greater than 15M. TAI is defined as starting from telomere and not crossing the centromere, and the fragment length is greater than 11M. LST is defined as the case where after deleting segments shorter than 3M, both adjacent segments are longer than 10M. Finally, counting the number of the three indexes of LOH, TAI and LST in the genome, and calculating the HRD score (HRDscore) according to the following formula:

HRD (homologous recombination defect) score = LOH number + TAI number + LST number, and genomic abnormalities are quantitatively evaluated according to HRD score.

The effects of the embodiments of the present invention were evaluated by the following methods:

samples were classified by whether or not they underwent biallelic mutation in BRCA1 or BRCA2, and then the distribution of the genomic abnormality assessment scores for samples that did not underwent BRCA1 or BRCA2 biallelic mutation was compared to the genomic abnormality assessment scores for samples that underwent BRCA1 or BRCA2 biallelic mutation. The present example tests 624 tumor samples from ovarian cancer patients and control peripheral blood samples. The samples are subjected to mutation detection of BRCA1 and BRCA2, and the result shows that the 122 case samples have germ line or somatic cell BRCA1/2 pathogenic or possibly pathogenic mutation. According to the result, the case samples are divided into two groups, and the sequencing data of the samples are obtained by carrying out the steps of DNA extraction, library building, hybridization capture, computer sequencing and the like on the samples. Then, by performing confidence analysis on the sequencing data, after the genome abnormality score of the detected tumor is obtained, the distribution of the genome abnormality evaluation score is obtained as shown in fig. 1.

FIG. 1 shows the distribution of abnormal scores of genomes of 624 ovarian cancer patients. In the above, negative on the abscissa represents 502 samples in which no biallelic mutation of BRCA1 or BRCA2 occurred, "BRCA 1_ pos" represents a sample in which biallelic mutation of BRCA1 occurred, "BRCA 2_ pos" represents a sample in which biallelic mutation of BRCA2 occurred. The ordinate represents the genomic abnormality score (HRDscore) and the width represents the number of samples for a particular score. As can be seen from fig. 1, the samples with BRCA1 or BRCA2 pathogenic or possibly pathogenic mutations had a significantly higher overall abnormal score distribution, while the abnormal scores of the samples without genetic mutations were overall lower, but the abnormal scores of the samples with a certain proportion were similar to those of the mutated samples. For this sample, PARPi can also be used to guide drug administration.

While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including the preferred embodiment and all changes and modifications that fall within the scope of the invention. It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

Claims

1. The application of a plurality of SNP loci in evaluating genome abnormality or preparing products for evaluating genome abnormality is characterized in that the SNP loci are biallelic high polymorphic loci which are approximately and uniformly distributed on a chromosome, and the group minimum allele frequency of each SNP locus is distributed between 0.05 and 0.5; the density of each SNP site on the genome is 16.5 per million genome bases; the GC content of 250-350 nucleotides taking each SNP locus as the center is 40-60 percent; and each SNP locus conforms to the Hardy-Winberg equilibrium law and simultaneously satisfies the condition that the group differentiation coefficient is lower than 0.05.

2. The use of claim 1, wherein the position of the SNP site on chromosome 1 includes: 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The positions of the SNP loci on chromosome 2 include: 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97,241994130,242062779,242099322,242134052,242167146,242214126,242261864,242355406,242396852,242430994,242473262,242509828,242535751,242605809,242651996,242699935,242737930,242776689,242842090,242872883,242909723,242937084,242963185,243001279,243052200, respectively;

The positions of the SNP loci on chromosome 3 include: 85398,122620,159349,192951,229772,265878,293670,357478,386858,420563,452169,482015,556186,591835,629079,641644,652407,664057,705014,742023,836863,957683,1034572,1067554,1106129,1132600,1167565,1199147,1233707,1299234,1325850,1350749,1382358,1419610,1455503,1486855,1514387,1547126,1580245,1615187,1643255,1668078,1698843,1721794,1753741,1788100,1819199,1849094,1879580,1928857,2008318,2037106,2076967,2115036,2152464,2195083,2231506,2267266,2308873,2375705,2408172,2439658,2482565,2519956,2607296,2716585,2747150,2776983,2811642,2835225,2864293,2902330,2937973,2974206,3008424,3038804,3071341,3104262,3188016,3278581,3308432,3339135,3377328,3444169,3490110,3518222,3554473,3588016,3630813,3696585,3731473,3766921,3793058,3825601,3860052,3903288,3947388,3979971,4010819,4043726,4084288,4127195,4163133,4201718,4242874,4321820,4361643,4429829,4468598,4509643,4581685,4622135,4657422,4697557,4766787,4806844,4893093,4929937,4969848,5004589,5081285,5113533,5148635,5183598,5233579,5273967,5305951,5343227,5402383,5434536,5474369,5510739,5541046,5580188,5608375,5681689,5715824,5751620,5788086,5840858,5909068,6007536,6040777,6089000,6120412,6157479,6191843,6226057,6258617,6328299,6362888,6407442,6446710,6488390,6526115,6572131,6618824,6651923,6723586,6752063,6787060,6825247,6873635,6963502,7123988,7158766,7199400,7243510,7291712,7335496,7370916,7400815,7433503,7476420,7509460,7550214,7591829,7631501,7676844,7708970,7787065,7823658,7863402,7895977,7958860,8029455,8076451,8159847,8192385,8233351,8274556,8319322,8364898,8416380,8453660,8544503,8589558,8632542,8670589,8707343,8729079,8771776,8805897,8915430,8954570,8991035,9033989,9072370,9112746,9203491,9254177,9303124,9328411,9378454,9430868,9486810,9543549,9634373,9680870,9742107,9794503,9880082,9924837,9962157,10042113,10079255,10106366,10183328,10248072,10321229,10362003,10406335,10442912,10492479,10665546,10758284,10796810,10842708,10887446,10931851,10977742,11061814,11104896,11151790,11197276,11236121,11284950,11336966,11387847,11481794,11522932,11604444,11640752,11673717,11703193,11743393,11819597,11859953,11933184,11960066,11992711,12079287,12168317,12216142,12259545,12297990,12345208,12395792,12443530,12484928,12525141,12565822,12605189,12638071,12715167,12757726,12796495,12831860,12906429,12943152,12994451,13042625,13081885,13121790,13162185,13202733,13240008,13280980,13312705,13357220,13398100,13442892,13479822,13598025,13635107,13673043,13740341,13778888,13823342,13943704,14003540,14063880,14117495,14156704,14251932,14290362,14324303,14362702,14398465,14436494,14519597,14566562,14608720,14651163,14696529,14737076,14782794,14831822,14878427,14953440,15003380,15102538,15150718,15182917,15278438,15325053,15361469,15402142,15445458,15484219,15520004,15570207,15661619,15701981,15798096,15849743,15901288,15941590,15990854,16029000,16067395,16113962,16190032,16315846,16359747,16459007,16589527,16627980,16753274,16797646,16841071,16888997,16936880,16986805,17092437,17149682,17189255,17297027,17345868,17455212,17513650,17703519,17813559,17860583,18017998,18082293,18137450,18191413,18247284,18299818,18404672,18457022,18519543,18570342,18617351,18658743,18743561,18780545,18861222,18913178,18965272,19024741,19148454,19258733,19313473,19429040,19500998,19572906,19629305,19688343,19745124,19793081,19885662,19930695,19971222,20007355,20047314,20120548,20158447,20195754,20236385,20275739,20321893,20359744,20401600,20445437,20487378,20519918,20570352,20608960,20700544,20741611,20776569,20821600,20868543,20908350,20954311,21001549,21081292,21118190,21164127,21198099,21244087,21292640,21336127,21373177,21422263,21459354,21490154,21525924,21620699,21653380,21690066,21729643,21761052,21793016,21820206,21852247,21935869,21962770,21988749,22015139,22048052,22078057,22110830,22139124,22170312,22197207,22231231,22269188,22303740,22341338,22383570,22421263,22459532,22501301,22544898,22608641,22644689,22693474,22725948,22773519,22825701,22879291,22918704,22957240,23005640,23051547,23113619,23152463,23224990,23271602,23315895,23367021,23414207,23511224,23646642,23691547,23732047,23769077,23805036,23848336,23970695,24004522,24048679,24099794,24152386,24192427,24231351,24270401,24304085,24350299,24443213,24494308,24534311,24632808,24670695,24711945,24747070,24782729,24818629,24857987,24904344,24939147,24975241,25010579,25037722,25074918,25115413,25150172,25184389,25214273,25249631,25288934,25327020,25364777,25403207,25435001,25475575,25513249,25549386,25586638,25626640,25728744,25784644,25838680,25890495,25939205,25992832,26042744,26098681,26150748,26205926,26250572,26303642,26363627,26421172,26509415,26544725,26575139,26618499,26655743,26693915,26743491,26786159,26826444,26874715,26961874,26994882,27046234,27079935,27113347,27148558,27213170,27254843,27299830,27343549,27433911,27487386,27527307,27569582,27616415,27687903,27728597,27821328,27866220,27905669,27943615,27986865,28027538,28071840,28117982,28158825,28211885,28259604,28317010,28374464,28435177,28506980,28572040,28633671,28801319,28843618,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respectively;

The positions of the SNP loci on chromosome 4 include: 36457,56076,80367,124902,182332,226937,272579,320897,361651,407393,452065,499439,535739,583034,628315,665779,739141,769298,810507,883039,920972,970377,1011417,1049875,1114351,1161798,1240810,1278004,1306886,1373622,1406658,1496783,1537914,1567158,1605843,1634784,1664874,1780419,1811328,1935055,1998120,2054055,2106765,2161429,2194374,2244674,2288238,2366664,2398055,2423366,2456802,2504195,2595468,2645478,2741679,2857374,2908782,2948514,2991526,3028401,3068482,3164628,3220761,3261763,3298395,3340889,3382389,3434167,3473650,3494228,3517485,3549038,3571181,3581893,3593301,3602070,3610486,3625606,3634306,3656013,3683470,3714836,3746318,3782455,3812631,3833120,3892445,3925213,3952815,3972887,4002998,4036180,4057717,4076723,4111202,4137752,4160310,4183878,4207215,4228738,4250241,4277847,4305537,4335824,4366950,4440539,4495118,4543407,4582183,4627958,4666770,4701962,4741418,4786670,4860254,4889621,4932445,4965462,5003283,5037445,5081995,5108497,5144868,5180055,5212544,5251594,5282794,5310453,5344472,5378053,5410837,5442765,5474386,5525897,5562539,5604800,5636113,5667134,5706091,5762623,5799547,5858579,5930920,6023171,6056325,6090641,6128624,6161577,6197404,6271416,6356557,6389642,6416861,6452814,6484168,6527252,6603943,6637273,6705590,6738935,6767566,6818015,6869307,6908751,6949223,6987446,7073187,7109184,7140918,7169275,7203849,7231418,7263980,7304496,7330321,7363331,7392523,7415699,7440604,7468947,7487800,7511012,7537063,7571761,7610416,7666722,7725585,7756195,7782804,7840332,7868217,7896213,7922096,7955294,7990930,8029018,8097789,8136641,8177203,8215226,8246502,8312738,8338034,8372856,8403533,8451179,8494089,8559688,8588179,8610899,8644405,8682821,8715672,8933168,9034510,9111280,9184457,9419658,9446609,9480019,9515883,9537431,9564484,9585071,9606018,9636355,9702790,9733115,9766886,9800679,9843356,9920086,9954238,9982917,10017979,10052817,10089253,10121012,10136685,10152935,10176594,10198514,10231237,10260765,10290420,10320891,10355396,10391902,10437334,10480591,10514681,10599205,10642159,10706970,10737954,10997737,11037998,11082149,11124523,11243343,11280398,11318311,11368670,11414198,11450699,11480557,11516449,11546396,11588899,11620694,11665013,11706820,11746643,11769076,11813105,11850401,11884465,11919586,11950395,11989859,12035048,12082491,12112707,12193889,12275587,12310722,12358940,12409447,12465168,12512865,12553096,12588094,12624701,12653988,12683297,12727586,12765282,12799832,12843654,12888358,12929066,12967195,13009049,13096420,13141039,13193386,13237029,13293417,13336573,13391329,13449807,13504752,13554557,13606027,13661643,13707225,13785739,13830615,13915104,14007710,14050263,14091440,14130567,14168299,14206434,14363148,14395094,14476568,14509817,14534626,14566932,14604890,14691717,14728549,14771119,14811600,14840518,14874138,14956607,15007988,15063390,15114305,15159192,15204853,15245140,15293023,15334214,15388838,15490752,15555221,15615479,15660184,15824974,15874537,15915388,15961555,16000542,16041619,16088567,16132084,16169755,16217627,16265834,16307516,16353893,16403682,16444413,16493698,16542294,16592117,16641382,16691200,16736331,16778299,16824435,16872076,16914832,16961656,17022015,17062007,17105777,17139437,17228148,17273023,17308473,17346374,17425937,17460970,17489883,17530699,17563687,17604802,17672465,17706071,17754729,17808337,17876943,17939302,18046636,18096948,18148869,18199611,18252106,18290930,18340461,18394023,18442406,18487049,18534169,18632463,18670863,18754700,18789221,18842624,18895094,18951799,19007280,19058515,19159497,19259080,19300189,19348177,19392182,19463717,19504786,19543063,19588900,19632142,19681035,19732689,19782712,19899705,19950098,20006151,20058664,20083052,20119727,20156709,20197183,20240093,20286490,20332458,20391615,20485321,20579306,20634072,20685544,20732701,20775383,20853948,20898558,20940550,20983806,21027322,21064253,21104021,21137001,21178999,21217985,21293490,21333298,21410659,21455256,21487844,21517194,21557180,21596543,21640489,21686957,21786688,21818459,21857425,21940697,21992543,22047433,22089812,22189941,22243808,22290611,22336096,22384063,22425837,22468621,22502130,22570233,22731822,22775690,22816662,22873033,22933965,22989505,23093028,23154778,23246187,23328370,23381513,23425588,23469584,23516403,23561069,23597396,23631652,23674005,23750569,23789477,23830741,23875589,23956205,24000544,24041628,24081446,24120953,24157323,24243483,24280371,24324927,24415092,24549927,24600388,24640911,24676440,24718497,24760535,24797566,24844929,24883062,24927682,25045341,25080036,25122890,25176277,25228583,25274171,25357164,25406189,25439633,25582496,25648141,25687153,25718984,25751278,25794583,25838901,25888370,25938806,26014228,26048141,26094992,26144084,26188992,26230326,26275336,26316816,26356092,26409537,26452301,26488853,26523592,26567378,26753223,26814210,26911129,27079874,27172472,27208505,27250649,27294111,27525746,27564839,27604705,27643547,27685167,27752434,27785567,27867912,27909347,27956188,27993916,28038705,28079899,28151913,28193573,28259975,28304630,283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respectively;

The positions of the SNP loci on chromosome 5 include: 28591,80330,111986,158000,185418,213460,243756,265541,326854,361861,400457,428044,489071,514600,549119,580051,620052,642061,668006,691777,718300,751989,779885,816751,850943,883311,998691,1029127,1048207,1096469,1136717,1170927,1199812,1228362,1259060,1280848,1306521,1370122,1397859,1475309,1512207,1622797,1654572,1686711,1723309,1759385,1794921,1833008,1858834,1889208,1926028,1952539,1992952,2020905,2058886,2087489,2149254,2177986,2221147,2258634,2288471,2317351,2346106,2371742,2401963,2446514,2512701,2540504,2573863,2605035,2675607,2783839,2860637,2897302,2937343,2977667,3014197,3040091,3067438,3089029,3151352,3179203,3215014,3244395,3277083,3309567,3339548,3373293,3407131,3481994,3514932,3549239,3584368,3622205,3646322,3709754,3739311,3821134,3862010,3905547,3947720,3985247,4056903,4136972,4176952,4214994,4254667,4283895,4317544,4363113,4408823,4451646,4503514,4547930,4648933,4689313,4782636,4826903,4870565,4905516,4942141,4975491,5046134,5082787,5119935,5151014,5192434,5226529,5256184,5291003,5321699,5361531,5406439,5452271,5509703,5551563,5621227,5658048,5706221,5742679,5775621,5806664,5835572,5867266,5938416,6014092,6050705,6096958,6177662,6215343,6252374,6300903,6337964,6376901,6418293,6498898,6532922,6562251,6595332,6624395,6664544,6792706,6913974,6993963,7041391,7098789,7141602,7186765,7263115,7303115,7337663,7380105,7435782,7483970,7529360,7619398,7671849,7755900,7798723,7841044,7883344,7924786,7992118,8018341,8037217,8106426,8136694,8261713,8339294,8381466,8498478,8530645,8561056,8594190,8635455,8674114,8714999,8784956,8824582,8871253,8915125,8948201,8987082,9038128,9083548,9127005,9162608,9228330,9272445,9315546,9356174,9396929,9441835,9485592,9531592,9562847,9650968,9701222,9847182,9894252,9931139,9971938,10002461,10036432,10083440,10141280,10189940,10308303,10365943,10435684,10476898,10515515,10553430,10591926,10633559,10666141,10745313,10831721,10874972,10910357,10948006,10984610,11029448,11076293,11112920,11148358,11236470,11289232,11324556,11365226,11403115,11446860,11484326,11522405,11566327,11614029,11657823,11707597,11746670,11825737,11876618,11918305,11960579,12009331,12050820,12099362,12141669,12188357,12233805,12336315,12384283,12430936,12531485,12623469,12674760,12716629,12826922,12914597,12994384,13132480,13211172,13252521,13295206,13378486,13423083,13467834,13517073,13614012,13663328,13711606,13813566,13881117,13923049,13971438,14006146,14040816,14078947,14119796,14175415,14218755,14308893,14350622,14396501,14443901,14491119,14579179,14629808,14667647,14722254,14763707,14850760,14941233,14987807,15038608,15088089,15129378,15179136,15233673,15286665,15330414,15491272,15552349,15610764,15655657,15706868,15809088,15869199,15920361,15972190,16023473,16071465,16113511,16160122,16209712,16259288,16305782,16362819,16410338,16501407,16574900,16619142,16653410,16724163,16767999,16829117,16861957,16895460,16999059,17058914,17086137,17194288,17237379,17283714,17333059,17374010,17418015,17460157,17499656,17517363,17624715,17645821,17696204,17745762,17789202,17820596,17863867,17905745,17957181,18017404,18057933,18137215,18179172,18218841,18296992,18332372,18362232,18403268,18435021,18466629,18508723,18552406,18655256,18692076,18738697,18793012,18850367,18900292,18948922,18987340,19026995,19072206,19113940,19156316,19199034,19247982,19302666,19342039,19380639,19419011,19457951,19495246,19549254,19601146,19652053,19700778,19742587,19797686,19849674,19897952,19949165,19988159,20038980,20241644,20286161,20329201,20372972,20416305,20493759,20531779,20564766,20608837,20719200,20810186,20862531,20916354,20970049,21013014,21134979,21188923,21235990,21284079,21360864,21458784,21513500,21532971,21560130,21582016,21774281,21823307,21864751,21908707,22004398,22053951,22100944,22154317,22267870,22311885,22412622,22453948,22501529,22612031,22670207,22715696,22760514,22867148,22922432,22971508,23052940,23091379,23134126,23178836,23225207,23269862,23302487,23343169,23377407,23420972,23475602,23544386,23591768,23623268,23656668,23692408,23729125,23761578,23805068,23854490,23885467,23940902,24048548,24093038,24126392,24201989,24250646,24292923,24330283,24382600,24488981,24520631,24588115,24635537,24684126,24736053,24783811,24830442,24873222,25014518,25070363,25119167,25173414,25293922,25404676,25491096,25583987,25633314,25687581,25727665,25767506,25799266,25870090,25899331,25932561,26004186,26045956,26091309,26133448,26174975,26260788,26304906,26350979,26389262,26436687,26491852,26538201,26576132,26612915,26654061,26701742,26747389,26789045,26816907,26846512,26887490,26926690,26960169,27064324,27126724,27173004,27222745,27280987,27332476,27386390,27480333,27525129,27569575,27613137,27762814,27872626,27913609,27952844,28000781,28051459,28107414,28155164,28204574,28249141,28293697,28342019,28383144,28434019,28526048,28579311,28635141,28684634,28729582,28788615,28927390,28964829,29007332,29044907,29079633,29128628,29177840,29212515,29325101,29363706,29405536,29445756,29475912,29508123,29551016,29589776,29623416,2965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respectively;

The positions of the SNP loci on chromosome 6 include: 151967,211215,243497,285984,321528,354101,373017,407496,444600,462929,494045,528568,611780,652056,686970,723959,761367,796433,830957,867209,923900,963300,1002406,1036815,1068909,1108340,1144302,1188100,1217908,1250317,1285521,1319106,1395427,1434925,1463535,1500664,1534344,1567011,1605258,1648892,1682466,1715849,1791818,1891709,1930663,2060072,2166230,2214632,2262794,2325562,2369492,2407481,2490391,2521754,2552939,2589808,2628943,2668071,2704475,2737204,2777344,2815277,2853342,2880480,2919303,2953560,3041557,3077575,3107282,3144826,3179222,3222210,3256473,3279127,3308312,3381759,3423587,3462885,3502666,3666833,3716550,3749436,3777025,3821627,3862273,3901224,3944586,3985834,4028023,4108360,4149025,4190126,4271667,4315480,4368431,4402324,4428761,4466210,4496219,4537791,4574440,4612410,4653371,4683015,4714923,4782412,4820277,4870030,4905947,4938982,4974088,5003987,5079237,5148778,5181660,5229259,5265797,5304008,5351524,5387602,5420642,5453893,5489864,5530595,5647113,5688576,5731236,5780846,5825331,5863211,5909813,5958001,5999332,6065950,6103709,6144552,6181768,6232032,6278028,6384319,6422355,6465553,6514123,6549127,6581897,6606050,6718461,6745234,6780016,6819029,6849713,6888560,6922016,6950098,7012032,7085512,7232996,7270881,7301671,7328267,7422329,7444241,7517509,7554466,7642748,7683278,7730254,7776336,7816954,7856850,7898529,7980400,8012812,8041545,8077422,8166567,8204413,8248234,8284191,8352518,8386086,8459292,8487369,8528008,8563498,8598496,8637318,8679579,8784507,8836128,8920969,8964533,9010731,9049101,9084400,9130600,9184857,9277213,9323458,9375620,9426953,9482271,9529203,9575673,9637645,9706545,9773802,9822969,9960805,10006058,10090687,10131177,10174652,10218322,10259823,10332713,10416004,10459311,10482201,10503336,10562475,10577388,10706503,10740422,10786720,10836938,10881404,10922715,11011100,11063362,11196923,11281742,11329235,11414705,11465141,11537014,11586435,11630685,11669514,11707941,11741649,11788703,11832737,11881875,11918687,11954693,11988024,12035652,12076676,12125541,12170951,12211721,12245559,12288769,12335338,12375643,12429862,12471888,12517124,12558084,12645050,12681799,12835015,12874870,12922022,12963708,13014227,13116222,13153314,13192799,13231251,13293570,13329355,13362716,13398846,13432272,13513622,13546503,13602013,13723128,13764846,13799494,13843846,13902302,13957851,14003405,14040139,14077382,14113617,14150150,14203872,14255473,14311039,14354347,14501602,14583270,14618307,14656963,14738582,14816864,14865069,14908323,14947558,15029972,15145279,15182037,15222059,15259168,15300953,15348722,15435269,15476700,15519017,15629223,15683947,15723361,15763063,15804525,15847048,15886281,15926822,15964299,16006213,16050501,16089389,16140197,16185967,16221045,16241594,16389578,16424956,16520249,16565472,16601127,16639118,16681323,16720087,16772452,16819151,16915370,16957479,16999063,17040313,17091097,17141776,17192383,17245424,17289545,17334641,17376791,17417376,17456826,17498937,17542668,17587301,17669727,17821166,17860951,17906329,17954426,18005863,18030179,18076141,18112715,18145927,18219375,18307976,18387064,18450920,18517922,18593042,18634813,18676802,18713818,18797392,18882998,19021288,19077434,19175191,19248973,19291506,19331923,19374999,19455796,19494175,19528592,19569186,19611120,19653252,19738236,19784579,19809033,19854105,19931686,19967069,20096612,20140016,20175484,20212606,20252093,20418329,20470930,20520353,20598865,20635026,20670293,20714466,20799198,20841292,20937984,21131143,21175492,21218478,21303195,21337490,21380141,21426960,21468829,21515018,21568585,21621012,21739773,21780724,21855730,21897661,22017317,22090538,22129677,22173648,22209151,22243965,22374911,22408330,22450262,22491435,22527391,22573546,22655242,22697499,22737762,22787601,22834310,22876526,22913339,22956022,23002162,23041376,23091400,23144229,23188059,23229513,23274977,23309017,23348187,23388486,23418298,23453200,23500598,23547686,23584830,23616717,23649127,23678135,23706272,23735498,23760775,23787317,23823804,23857033,23925051,23957912,23992877,24033828,24077431,24124484,24167478,24236574,24280881,24318579,24401654,24433643,24457838,24484419,24515688,24555220,24596843,24719058,24846863,24940849,24971403,25005966,25045904,25084858,25165141,25247680,25312996,25340870,25376467,25406680,25441053,25490370,25531925,25585640,25631179,25669338,25749554,25789021,25884785,25929404,25967927,26021544,26062398,26104632,26142823,26190863,26228043,26277411,26320364,26366428,26402676,26451553,26499179,26555484,26599855,26742983,26798697,26859533,26901604,26955178,27003483,27101891,27152008,27187379,27276171,27331782,27423248,27471511,27516769,27569607,27621255,27812807,27861346,27984907,28038251,28096196,28197469,28254770,28308671,28395437,28442333,28482917,28611154,28688843,28714778,28737295,28761471,28782734,28815952,28875686,28902608,28938353,28973712,29010587,29052301,29093327,29132271,29164873,29210724,29257320,29299503,29338563,29363697,29385415,29443889,29477783,29504206,29527621,29564486,29591469,29621536,29643877,29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6695,166920113,166953012,166993009,167032361,167071948,167148204,167183881,167213777,167245665,167273761,167318323,167392527,167424293,167456036,167505548,167544464,167584647,167620431,167641005,167674303,167691342,167714737,167742636,167776834,167811787,167844197,168093726,168198522,168274042,168326684,168391985,168416272,168445020,168504184,168534170,168557632,168645267,168678889,168706362,168738643,168774656,168799631,168834662,168883406,168915660,168944930,168973265,168995544,169013720,169035322,169060658,169097222,169131335,169169092,169202643,169233339,169247748,169266997,169293930,169313513,169334697,169365193,169395027,169434020,169471271,169508634,169541179,169576662,169607718,169636624,169712830,169752931,169867207,169916583,169958850,170025492,170065117,170173967,170208403,170249889,170364566,170398825,170428032,170455906,170496430,170529253,170553895,170579994,170625298,170664813,170703743,170727677,170758245,170778521,170845354,170888363,171009273, respectively;

The position of the SNP locus on chromosome 7 comprises: 63018,96312,117442,143945,172014,199624,220023,341524,511617,594686,686134,730834,828626,904368,933749,954862,977429,1017698,1049123,1072146,1100931,1132685,1157795,1189279,1210688,1242328,1275578,1310386,1334533,1366777,1410019,1457450,1495283,1570126,1610365,1652801,1691210,1792413,1852166,1888758,1918941,1944205,1975176,2008725,2048017,2124355,2200973,2240657,2280845,2315950,2403128,2430624,2473125,2512252,2546631,2585570,2617042,2644589,2673288,2742336,2764724,2836836,2874835,2938109,2966869,3001173,3033975,3094488,3127660,3155668,3185260,3242371,3272227,3334836,3359708,3387838,3420443,3453333,3519885,3555462,3629521,3662146,3754653,3791115,3821953,3888321,3914875,3950836,4026009,4060005,4086123,4117436,4146288,4178823,4210874,4238412,4266583,4303279,4331707,4367133,4398657,4425837,4451320,4513330,4539982,4575849,4605654,4657654,4744796,4777207,4810712,4842577,4939038,4977659,5014519,5053287,5095577,5193946,5288168,5321113,5351444,5424636,5470363,5500145,5536379,5568863,5605445,5640871,5681903,5725443,5770400,5868561,5897906,5996104,6045597,6083951,6218003,6262355,6305817,6347041,6379537,6440883,6470206,6503384,6545369,6593496,6674724,6710094,6720384,6760203,6857441,6887323,6911082,6944645,6974952,6996353,7015797,7035605,7070743,7102584,7128515,7161793,7205854,7242686,7269777,7309885,7343138,7377368,7408659,7446846,7487308,7533479,7583953,7694722,7732347,7771121,7806815,7844340,7875856,7909659,7946590,7988650,8075115,8116836,8154136,8189629,8225224,8262922,8309275,8350404,8391115,8436060,8479629,8520389,8558959,8600498,8639678,8674306,8699560,8732406,8823447,8895484,8971784,8995414,9030356,9087523,9116799,9147011,9179684,9212596,9251214,9292876,9329824,9374548,9423414,9473970,9515348,9553037,9591611,9625115,9651917,9689761,9719759,9809503,9876688,9917581,9958144,9995571,10032228,10070089,10141996,10178822,10222749,10293191,10368770,10404393,10449020,10516005,10552259,10592286,10629615,10673337,10725451,10780738,10831607,10873865,10948631,10987457,11031114,11072214,11115578,11163459,11208989,11241635,11281957,11316527,11343074,11379953,11422942,11472736,11523249,11559288,11590583,11618675,11665971,11750617,11786624,11822682,11862342,11906401,11932615,11974451,12007576,12037234,12070560,12102313,12133937,12171723,12200287,12229796,12260546,12290724,12323936,12351245,12377937,12407582,12482517,12514636,12543622,12583153,12616242,12656390,12695442,12761698,12785780,12825805,12900316,12934776,12963866,13010649,13049523,13128696,13163517,13196721,13236232,13271297,13304611,13336929,13378131,13421817,13466283,13508540,13547757,13582614,13661045,13692529,13798406,13836721,13886700,13919741,13958662,13997159,14030119,14110358,14150643,14196943,14238703,14276766,14306522,14345939,14395580,14440441,14482710,14557048,14599259,14641395,14685825,14729087,14808055,14843912,14884744,14922349,14996167,15033129,15065798,15107479,15139814,15179443,15225415,15260042,15304266,15342244,15377318,15407982,15436505,15473921,15509221,15551301,15600816,15635022,15668307,15718461,15760654,15803580,15853046,15892633,15926770,15964754,16008390,16049458,16086674,16126723,16170530,16218545,16263161,16308329,16349864,16386034,16423819,16455330,16502332,16538967,16577376,16624693,16661694,16706051,16747711,16777333,16809170,16842760,16877706,16908741,16942661,16977505,17012944,17053030,17090223,17129241,17183806,17229862,17285635,17357630,17468811,17504506,17545170,17574553,17610758,17642946,17679434,17711759,17743563,17814607,17928480,17978343,18058852,18161620,18306410,18350296,18402849,18449665,18497011,18552373,18605487,18647876,18697666,18748952,18792116,18828964,18864122,18912137,18950118,19000113,19046946,19089438,19137857,19177639,19219778,19317754,19362075,19436443,19483054,19522027,19546810,19590347,19622050,19657122,19697067,19746541,19788301,19865278,19903503,19934505,19969897,20003753,20047875,20092407,20218520,20263578,20301688,20336810,20384620,20472512,20509672,20549389,20647703,20687181,20716213,20755114,20910451,20967325,21015161,21061980,21147557,21188774,21237468,21278141,21355243,21397981,21441078,21482567,21519608,21563052,21595155,21633505,21670593,21708050,21775076,21807773,21838330,21868394,21902986,21938469,22012548,22046080,22077458,22119972,22155760,22199634,22252165,22349769,22392027,22426826,22465557,22501109,22539421,22589911,22635725,22702016,22745623,22821881,22857589,22889410,22923649,23025891,23072077,23117765,23165119,23205853,23251746,23294648,23334502,23389444,23484260,23532235,23582052,23628380,23730246,23821784,23859374,23945976,23989900,24071397,24159020,24197906,24276803,24308281,24380444,24417090,24452713,24495798,24582398,24634797,24682520,24726752,24763467,24807405,24858444,24904868,25033198,25078712,25243976,25322653,25363617,25445040,25475585,25515926,25562381,25602216,25637958,25696093,25739360,25784462,25828569,25878124,25978571,26024687,26079330,26125625,26171823,26222973,26261143,26315472,26358318,26391892,26487587,26573960,26606005,26640665,26674108,26726320,26832022,26880519,26936869,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respectively;

The positions of the SNP loci on chromosome 8 include: 186271,220987,240492,266757,294720,323671,350137,390206,423879,453857,486343,525112,558379,582945,613773,636539,660944,695943,734398,758565,831649,876613,915745,943496,971298,994759,1026619,1053621,1085374,1114974,1135242,1152074,1168708,1191510,1265149,1287645,1355919,1376122,1402566,1423482,1452615,1478325,1510233,1536758,1563428,1588509,1611169,1641167,1675219,1707272,1776376,1798179,1817799,1837443,1863383,1901110,1927246,1955393,1986262,2008847,2033642,2051979,2077072,2091879,2111830,2136501,2159512,2181472,2207709,2221208,2238977,2264525,2284777,2307223,2362100,2455325,2485492,2512560,2537271,2566825,2596341,2630935,2684495,2716359,2742089,2769298,2826822,2861030,2889651,2912529,2938619,2964503,2996150,3029672,3082618,3134712,3156668,3171662,3193785,3213092,3234119,3256288,3276650,3299369,3323760,3344541,3363441,3386424,3408229,3422471,3442377,3460557,3479964,3498904,3519063,3538528,3559268,3572647,3588760,3605823,3626217,3643120,3661040,3679619,3699344,3737310,3757018,3776571,3795261,3813492,3830442,3847994,3867910,3900551,3915562,3935720,3956297,3992617,4022412,4054448,4075464,4094658,4119457,4142987,4161050,4174631,4193502,4233767,4254058,4275087,4292832,4308183,4324194,4349565,4382286,4410318,4438436,4489464,4514626,4601254,4622263,4644553,4665649,4690488,4721066,4752088,4789067,4803200,4823714,4846986,4877391,4903970,4926972,4955782,4979961,5047528,5073843,5098285,5127400,5150901,5169199,5189283,5213378,5235928,5255235,5283533,5307217,5335495,5362900,5391562,5412893,5438215,5463043,5488335,5509574,5533627,5555962,5579775,5601342,5619062,5643720,5668625,5695063,5725285,5751753,5778414,5803576,5825826,5846504,5883949,5911954,5934489,5960848,5987937,6011141,6036358,6063568,6085381,6132391,6157388,6191167,6215788,6236602,6259136,6281138,6312346,6337080,6364575,6414013,6438204,6464103,6489190,6516722,6544798,6574104,6607821,6635600,6664058,6716282,6769704,6797103,6826140,6888488,6968854,7005008,7216021,7332979,7763738,8004693,8077066,8101188,8136280,8170081,8205287,8244991,8275605,8302079,8329260,8363740,8392274,8427415,8462948,8492809,8522632,8557526,8586386,8612786,8643992,8673320,8709716,8742067,8773510,8803696,8844117,8870543,8898016,8963610,9039838,9072121,9101373,9129826,9159630,9191554,9251693,9282466,9317106,9356802,9393831,9431033,9467624,9510067,9561945,9597824,9634944,9669885,9706115,9735594,9773359,9813236,9861916,9937455,9977476,10016471,10052546,10085359,10112595,10139470,10207418,10247816,10280039,10311704,10342122,10373694,10401785,10432909,10469030,10542007,10571465,10606954,10638401,10668637,10697649,10744284,10789345,10828598,10860846,10896425,10931497,10967122,11001951,11036975,11076418,11110753,11148157,11186674,11226071,11267737,11299256,11360494,11450783,11489579,11523106,11567992,11610567,11634650,11686487,11705779,11740508,11771619,11791320,11816929,11849745,11875316,11929422,12007364,12239662,12312540,12407103,12424140,12443223,12481030,12508172,12531178,12559874,12630974,12662403,12697757,12729545,12763577,12797831,12827931,12855570,12882634,12903974,12927207,12960335,12995420,13023950,13061579,13140305,13170576,13194053,13222549,13251422,13315983,13345414,13377700,13405541,13436422,13462198,13513544,13537834,13559526,13584946,13604103,13623608,13646455,13666813,13688497,13713791,13733644,13784153,13803680,13824535,13882528,13905752,13925152,13957144,13987423,14023484,14057645,14083622,14108630,14136161,14161272,14195730,14231670,14257880,14281719,14311502,14341787,14366045,14424429,14456327,14484778,14505171,14534352,14567061,14596584,14631530,14672930,14707570,14750415,14791669,14833412,14896349,14932322,14962249,14996765,15024895,15084051,15120258,15151088,15184032,15214803,15237968,15268341,15291893,15318517,15354418,15380848,15411783,15448124,15480206,15512783,15546627,15583206,15616572,15646305,15669365,15687517,15706522,15730153,15780390,15807268,15837443,15871892,15913605,15940614,16025885,16052589,16089634,16121873,16161121,16212273,16253333,16297220,16344655,16373068,16406598,16441593,16481944,16519891,16555109,16586902,16617343,16648148,16735406,16773420,16815577,16842829,16900593,16942849,16990621,17031164,17065569,17114512,17157044,17190038,17222967,17251155,17307015,17334539,17358496,17385836,17416251,17443470,17462624,17485789,17533418,17556506,17586307,17618569,17644219,17700055,17726054,17748582,17810390,17847984,17883147,17911937,17936982,17975547,18006140,18034779,18064807,18090403,18124916,18153569,18190845,18215623,18243113,18300954,18328552,18430602,18458721,18484830,18546582,18578496,18617010,18650909,18679225,18715533,18757176,18794531,18822548,18852397,18919720,18947351,18981713,19080556,19113646,19145226,19177567,19260240,19296468,19332546,19397288,19462667,19497883,19532298,19570709,19607661,19642088,19725412,19767298,19809427,19838578,19876797,19920578,19955920,19995559,20028210,20104470,20138261,20181698,20221679,20260760,20295746,20330469,20361185,20397418,20438736,20515550,20557049,20589564,20625285,20667432,20788373,20852077,20889926,20930056,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respectively;

The positions of the SNP loci on chromosome 9 include: 39360,105953,164831,205297,245032,271822,333416,361818,392670,423004,459345,494342,557844,591562,618813,647999,667391,691376,724217,751121,780835,803851,834655,857511,880438,906052,935503,978265,1015337,1046495,1078694,1113688,1169543,1205747,1243967,1278833,1307782,1338005,1372889,1413166,1451966,1479100,1506101,1560678,1617277,1649782,1685741,1715256,1744771,1774821,1821515,1853425,1889540,1922303,1965646,2011345,2055697,2095958,2135494,2169898,2201807,2265003,2299042,2342966,2377823,2414851,2486550,2522475,2553112,2593528,2632315,2665492,2697979,2734539,2777770,2819410,2864224,2901344,2936285,3022592,3059740,3096420,3134294,3166207,3205480,3250753,3299728,3452551,3521236,3584112,3627626,3688610,3729256,3766582,3812356,3854070,3928151,3966486,4008212,4111864,4151884,4184065,4255384,4285088,4316407,4373432,4401005,4434012,4470855,4507192,4549314,4593157,4631675,4658662,4696927,4727775,4755298,4825979,4855912,4902317,4945746,4999323,5052359,5100733,5193277,5233373,5269575,5318703,5360766,5397662,5433388,5464376,5506429,5553541,5606709,5653758,5700010,5746646,5889205,5945312,5995523,6051358,6148072,6201575,6254567,6299810,6413904,6462215,6515920,6600377,6629939,6658080,6685019,6716511,6747799,6788012,6828441,6864636,6942522,7006663,7041039,7082397,7120851,7154851,7187974,7224722,7261450,7294617,7325806,7361595,7456295,7497097,7529861,7560844,7595374,7640694,7677376,7713039,7747510,7788633,7878626,7916560,7959752,8002270,8045999,8094390,8132480,8208952,8244384,8309392,8334420,8367692,8397775,8430892,8470268,8508597,8556602,8636983,8675050,8710109,8743408,8769885,8834563,8866527,8904596,8933267,8955740,9000935,9068928,9110552,9149546,9189926,9235410,9274259,9318688,9357065,9396251,9464912,9498018,9540907,9580946,9619605,9661211,9709808,9747105,9780049,9812087,9845152,9879623,9908756,9942685,9975058,10011536,10048205,10116005,10147116,10190773,10230141,10263623,10290056,10336685,10380125,10420097,10455033,10487367,10561559,10671848,10708866,10752338,10836932,10884513,10931834,10974159,11007684,11033665,11071160,11098475,11125902,11162510,11199226,11239025,11269531,11311022,11438424,11476113,11515414,11557876,11594486,11623933,11660080,11698942,11734433,11767921,11800746,11835319,11868796,11908303,11952128,11998261,12032864,12078769,12117309,12166969,12203061,12275962,12313945,12347724,12370472,12399142,12452348,12495286,12586806,12632288,12673731,12709441,12748587,12785073,12830941,12866358,12892306,12927866,12961551,13011791,13058128,13102063,13161000,13224887,13277534,13332878,13386175,13445508,13493036,13532112,13562874,13599352,13675371,13716005,13751764,13781570,13812637,13851213,13879957,13919583,14010312,14045800,14088346,14141703,14224301,14266746,14312400,14402079,14442529,14487611,14532789,14567207,14608670,14649882,14694816,14733642,14811009,14847780,14887606,14934720,14979843,15063368,15098525,15133328,15171759,15216293,15258922,15292455,15332701,15401044,15442541,15477436,15520755,15615321,15678259,15726267,15824541,15952258,16037030,16081813,16122631,16162525,16202674,16226780,16262884,16301484,16334986,16408826,16454714,16493143,16528611,16573486,16618001,16667341,16710899,16749782,16815861,16886487,16910898,16935343,16961173,16992122,17030305,17064226,17112944,17151510,17195804,17238393,17274815,17344907,17468106,17506823,17547664,17580292,17652883,17690174,17721401,17746569,17778061,17818007,17858434,17898857,17937633,17972120,18016573,18063949,18104533,18143954,18187511,18237789,18275275,18305489,18348274,18395119,18432139,18478894,18522832,18565216,18601951,18634268,18670579,18719142,18761687,18837987,18882257,18911778,18943380,18971932,19005829,19035850,19076313,19117038,19154738,19190629,19233679,19266141,19306663,19347663,19390407,19430459,19472080,19513554,19593235,19642524,19683409,19723243,19762691,19812437,19861933,19900013,19944652,19990073,20031656,20070944,20115057,20162853,20204823,20242344,20280828,20323424,20376023,20443334,20502104,20589530,20630614,20735804,20785784,20840240,20897424,20989643,21034163,21081822,21129739,21171823,21202867,21236589,21282578,21328806,21368666,21417570,21460710,21507183,21553178,21601812,21675670,21711815,21743288,21781867,21826463,21864552,21918203,21967676,22010412,22063019,22133984,22160768,22196508,22244294,22288403,22329580,22379411,22420204,22465207,22509658,22549535,22591196,22637057,22732903,22780966,22872321,22914592,22950406,22988063,23026272,23065716,23099607,23136745,23173989,23264340,23302726,23347980,23385738,23424567,23516909,23561054,23607571,23679709,23721349,23767047,23815595,23924422,23973389,24061320,24105279,24148652,24185915,24243377,24291960,24389265,24446133,24551983,24607643,24649916,24725322,24773842,24818504,24852695,24895277,24930442,24970615,25012405,25059297,25124412,25161718,25239583,25285076,25385116,25415713,25451237,25496001,25538406,25612202,25722614,25765616,25782400,25825227,25870079,25924324,25968015,25995534,26033758,26087831,26141431,26190855,26242441,26300424,26349577,26394764,26451025,26498623,26532846,26571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633,141063232,141084494, respectively;

The positions of the SNP loci on chromosome 10 include: 106126,137212,202527,261650,315732,390358,419916,444555,471339,501504,538317,574326,607922,678000,723150,761649,777642,807330,837450,881998,936873,991644,1061665,1132980,1170496,1205850,1234510,1270534,1307655,1343759,1376968,1407539,1434704,1494010,1515644,1551548,1583406,1605704,1626935,1651002,1675929,1705879,1738482,1765005,1851858,1917708,1977423,2046453,2101136,2172065,2207785,2278085,2310137,2344595,2371598,2399399,2433400,2466878,2504343,2535669,2562642,2625209,2656120,2694562,2730860,2766759,2794937,2829929,2874739,2914753,2954160,3039787,3071854,3096617,3121077,3146155,3163175,3180298,3212358,3246569,3276965,3409675,3453522,3487380,3521369,3605732,3658059,3735925,3770581,3803035,3837555,3869607,3906885,3940706,3965873,3988667,4021907,4062327,4103901,4140580,4168171,4218425,4251861,4364598,4404105,4525591,4555699,4597847,4630288,4657550,4696289,4740045,4784070,4824926,4886868,4915912,4961369,4995058,5027931,5056002,5090805,5129139,5151354,5179882,5214831,5252902,5325918,5363083,5397491,5471470,5510802,5546087,5619116,5647078,5681032,5712693,5802956,5842240,5886570,5958072,5991569,6021885,6052068,6079483,6112291,6150311,6182749,6211592,6238963,6265329,6301078,6341206,6373848,6454924,6488017,6527270,6564883,6611621,6687618,6726766,6764797,6807730,6846265,6913849,6973882,7009557,7038968,7081699,7117594,7149998,7194265,7239793,7274741,7312200,7361749,7404505,7445901,7490206,7523475,7555492,7588290,7622217,7686343,7721859,7756155,7795548,7877290,7917798,7969567,8065087,8099629,8123191,8150102,8183039,8217921,8249865,8283928,8321660,8362245,8397816,8464581,8550507,8582358,8658846,8702460,8740732,8781277,8897261,8945648,8983047,9023719,9058671,9094424,9132408,9171654,9213854,9259428,9306064,9349500,9452439,9512428,9553961,9612515,9671078,9796000,9857091,9910828,9955333,9991667,10029896,10065438,10104399,10140203,10220981,10262842,10300168,10326331,10370918,10422594,10510959,10556072,10592979,10629297,10668715,10718024,10758526,10800504,10844526,10892091,10979955,11033600,11084164,11158063,11197845,11239010,11275566,11308616,11346374,11388639,11418955,11456364,11492868,11543086,11656848,11699856,11730196,11759046,11821473,11858114,11896420,11928072,11957748,11999791,12047767,12087005,12161411,12206169,12253183,12294890,12324964,12426386,12499594,12533173,12566199,12598121,12663986,12743559,12778206,12807287,12836751,12869284,12893229,12941153,13001186,13032586,13069718,13103657,13134648,13169264,13211533,13250133,13281667,13313259,13348512,13433417,13473087,13511986,13554112,13599687,13642872,13683519,13714057,13741505,13772503,13808113,13832761,13859564,13896605,13926123,13959305,13989216,14028674,14093716,14131835,14166745,14235685,14273535,14306643,14344556,14378449,14415867,14440662,14476854,14512559,14552207,14592997,14623195,14661117,14757013,14800569,14829883,14863375,14918316,14965511,14995464,15027645,15098311,15134623,15170431,15214537,15257383,15298555,15342661,15450994,15522841,15548747,15583365,15616714,15656020,15698576,15745059,15785720,15829458,15887674,15943681,15988352,16025697,16113376,16150889,16187157,16232149,16271816,16313333,16348783,16383058,16419974,16444680,16477500,16515573,16553349,16591841,16626515,16674290,16710032,16742510,16779757,16818105,16849659,16877859,16921214,16965178,17063577,17144768,17181979,17222557,17259863,17298472,17331544,17397448,17424271,17466752,17507512,17542447,17587121,17702921,17740411,17793756,18358517,18397597,18436647,18470174,18663585,18702356,18770298,18808692,18847041,18889907,18975185,19004994,19045354,19088771,19127973,19173550,19246810,19387126,19426549,19459979,19490933,19519981,19551922,19627998,19662132,19762077,19793829,19828832,19875303,19912246,19943290,19988543,20080740,20120750,20155618,20199105,20239338,20282191,20318588,20352631,20429371,20471205,20509788,20547231,20624933,20661179,20740616,20780095,20819892,20892992,20934100,20975654,21012039,21058596,21143722,21187945,21236507,21277980,21356409,21394129,21445236,21528348,21615569,21647453,21697652,21749246,21809706,21873712,21996118,22061494,22277065,22339708,22463594,22564924,22629414,22689404,22738919,22791353,22833928,22872674,22910489,22950152,22995580,23044757,23137721,23185723,23237568,23328733,23469422,23528023,23580946,23631278,23677090,23717462,23755039,23795334,23883517,23922510,23976996,24018500,24101521,24135231,24187192,24226419,24268482,24312048,24415337,24467351,24502629,24547110,24593546,24637755,24675218,24764631,24807097,24850658,24904115,24967176,25028479,25078088,25124826,25166578,25197663,25240084,25285385,25367066,25417504,25460936,25523699,25577521,25641379,25668917,25709364,25739714,25784245,25829906,25917909,25956113,25994034,26024322,26063061,26110653,26154038,26182569,26221380,26273616,26315345,26346047,26366576,26421847,26471289,26516639,26549427,26589814,26617542,26657758,26696509,26733753,26768622,26814137,26857582,26874089,26924489,26938434,26961039,26984146,27016642,27063077,27112414,27144553,27179667,27215087,27233815,27265194,27314400,27360773,2739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The position of the SNP locus on chromosome 11 comprises: 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respectively;

The positions of the SNP loci on chromosome 12 include: 151272,222812,261839,292946,324670,362077,506893,540264,576541,606598,670743,698043,771785,813197,858536,903636,950683,987634,1021159,1088357,1129982,1177343,1209113,1382293,1425657,1465409,1503341,1587160,1614615,1646825,1683582,1722328,1759929,1804194,1853291,1981349,2023486,2113282,2151060,2198671,2234440,2290086,2334467,2440464,2482943,2574613,2619268,2663185,2759141,2799284,2852349,2932177,2975253,3046569,3084349,3125328,3183163,3212998,3240295,3340366,3372141,3401883,3434902,3478435,3579369,3621711,3665097,3711017,3795006,3843922,3875602,3913900,3968977,4011466,4088850,4129956,4173938,4225089,4268844,4311442,4349455,4392530,4471635,4543570,4589934,4698860,4737889,4869017,4916963,4951809,4990779,5035433,5083083,5123695,5158463,5201737,5245668,5325561,5374704,5431867,5472611,5522436,5618933,5705316,5773880,5858461,5916833,5997095,6032326,6061555,6093048,6147110,6180510,6217504,6252482,6286671,6317852,6357363,6396786,6432148,6458856,6491078,6526744,6563698,6631169,6672191,6779333,6826336,6861247,6908146,6935955,6983903,7024022,7067226,7115989,7178872,7284301,7334581,7376398,7420219,7482768,7544401,7595836,7653039,7709867,7748922,7793279,7832486,7870461,7907101,7948010,7972686,8041326,8075677,8144649,8176687,8227318,8278181,8328697,8364266,8385143,8408977,8446982,8479885,8543038,8576248,8611428,8661939,8703947,8739758,8783624,8825781,8871953,8920224,9004667,9037134,9087544,9135257,9188757,9297403,9349955,9428660,9474509,9504891,9536566,9565534,9614685,9666643,9731939,9766785,9813188,9853650,9889727,9964966,10010411,10087298,10124661,10161067,10204478,10252944,10289164,10322186,10417105,10501750,10532326,10571658,10600154,10645762,10681543,10712195,10760443,10802586,10844383,10887323,10933626,11076230,11158572,11173620,11183832,11203429,11213446,11224770,11232520,11241868,11275926,11284988,11316430,11349267,11393463,11442155,11485673,11560553,11601042,11674254,11715550,11765325,11807184,11849379,11891441,11930117,11974707,12019754,12088462,12130518,12166381,12198858,12228034,12263940,12317707,12365529,12419719,12455114,12565055,12594654,12635275,12687224,12734174,12777557,12826887,12870695,12908786,12952018,12989850,13032065,13067561,13104160,13149595,13195538,13254715,13361241,13402605,13449545,13497985,13535742,13576153,13611575,13651566,13734133,13775800,13833593,13873619,13926911,13967182,14015052,14065870,14109457,14153261,14201273,14251761,14293079,14368308,14413021,14456090,14498812,14601352,14648500,14696979,14793220,14840113,14885245,14984361,15037076,15075854,15112916,15148937,15227822,15270067,15310339,15366321,15430821,15566369,15610073,15654216,15690733,15734849,15842436,15903617,15964714,16020006,16069383,16124692,16172573,16232460,16273308,16329144,16409383,16453225,16494839,16528684,16575046,16622136,16674932,16737396,16811624,16874107,16930595,17052329,17117753,17186396,17247025,17302851,17359219,17462145,17510913,17556694,17596962,17643629,17695007,17740848,17782144,17936069,18028597,18082924,18127570,18182709,18233323,18279922,18331234,18379840,18423992,18470418,18527463,18571906,18609971,18666529,18717609,18769922,18845281,18886980,18932012,18980988,19028311,19077503,19116247,19169602,19216447,19256882,19309304,19351689,19404820,19546228,19582943,19622218,19654583,19691773,19779749,19809623,19850778,19920004,19988685,20023668,20063968,20114660,20159638,20183575,20230384,20278893,20317889,20358369,20406470,20453061,20498871,20547182,20588037,20634983,20731615,20774882,20813524,20855696,20927006,20959603,20990987,21019837,21057442,21131622,21167811,21207728,21252930,21339380,21376213,21415519,21456222,21495910,21545759,21593738,21624398,21750254,21796814,21828677,21936318,21988087,22036979,22094801,22152130,22186582,22224015,22260998,22304887,22356763,22403123,22442707,22491597,22549958,22630828,22688479,22750537,22808074,22860778,22902676,22943719,22988592,23025013,23127833,23217064,23312222,23426527,23567892,23624745,23677328,23733332,23781672,23826667,23872812,23922163,23969087,24014044,24063219,24117091,24152079,24190854,24228187,24267639,24311226,24356254,24400694,24435683,24475508,24514884,24557317,24596843,24643990,24697505,24749731,24801240,24891230,24930390,24962007,24995892,25042601,25087022,25120045,25156560,25193158,25230121,25306242,25354828,25396085,25439169,25476261,25513333,25551464,25582515,25620127,25666255,25703936,25754026,25794790,25840390,25896843,25939117,25984408,26023589,26130232,26167734,26205999,26245229,26297245,26338730,26382335,26424120,26462580,26561955,26605769,26687447,26737472,26775614,26824366,26875632,26925507,27009893,27057512,27109888,27164821,27215813,27311884,27359892,27403466,27503743,27550462,27600090,27636924,27683792,27731851,27774682,27812764,27909254,27986663,28036942,28083409,28126776,28167619,28208832,28249464,28300257,28347456,28354215,28354653,28410865,28478864,28538278,28587583,28640936,28705864,28851559,28959726,29028475,29067176,29112196,29151248,29274850,29360783,29406213,29443381,29485449,29542495,29582321,29632278,29674302,29712571,2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respectively;

The positions of the SNP loci on chromosome 13 include: 19045719,19188901,19230344,19300112,19325256,19354163,19386447,19420255,19447571,19484083,19524321,19560486,19595824,19627059,19644551,19651313,19670296,19720207,19806777,19880021,19919738,19939348,19961373,20036991,20097234,20221817,20266522,20310651,20438883,20476274,20565736,20616864,20671255,20701448,20743417,20778464,20810602,20850011,20917309,20946163,20982708,21052875,21087336,21121787,21164732,21210042,21255689,21337862,21436701,21481665,21513679,21569345,21604456,21641565,21679558,21711476,21753012,21794696,21834597,21875315,21905870,21944100,21989201,22039137,22115948,22158604,22298530,22336428,22372894,22415097,22446077,22546747,22580579,22659312,22707533,22753304,22791888,22901132,22948884,22990965,23041595,23079072,23124255,23161271,23200776,23241794,23281078,23344260,23383039,23455870,23489845,23523452,23541312,23594887,23631790,23697519,23764917,23823888,23861945,23888328,23939872,23978217,24019346,24061960,24097928,24135592,24300694,24345651,24388701,24460390,24490761,24517659,24543328,24577652,24612191,24639957,24673653,24703260,24738246,24771545,24800996,24841178,24876269,24914139,24947695,24975915,25008380,25065429,25137710,25183855,25252900,25286750,25327470,25368922,25493186,25526788,25556511,25588341,25617381,25688985,25725541,25767300,25803260,25850579,25891408,25973050,26005839,26044668,26134731,26181143,26222618,26330408,26374077,26460040,26504956,26538827,26587626,26650959,26685792,26724447,26801972,26846070,26895488,26940428,26991109,27028726,27058326,27103340,27269165,27302114,27382269,27415672,27456315,27489315,27527846,27592492,27635476,27722952,27766235,27860778,27936282,27969228,28004708,28037669,28111402,28162216,28314257,28394625,28431981,28466412,28503699,28545300,28577554,28611888,28772792,28824947,28914255,28958955,29001721,29046198,29087598,29126720,29160578,29234459,29271911,29320342,29368854,29463968,29515205,29557668,29602213,29643788,29680606,29730124,29776536,29810676,29856755,29896391,30021891,30058398,30099093,30140676,30181404,30231283,30274920,30313336,30359674,30409304,30455802,30495038,30525943,30553913,30586435,30622662,30662834,30738060,30782504,30826495,30872377,30911572,30951853,30982367,31019747,31059171,31191944,31248916,31288052,31322069,31364838,31407137,31456247,31493856,31538544,31576684,31616425,31656881,31691095,31740361,31784140,31830919,31890396,32014953,32065787,32097851,32147537,32190990,32235008,32280416,32371707,32423327,32463165,32505503,32548039,32632660,32684751,32727903,32769635,32813741,32864646,32899902,32913999,32927610,32969027,33004788,33062542,33110361,33215969,33261602,33366427,33410855,33458406,33496848,33532366,33561295,33629446,33675791,33716982,33752591,33795134,33845720,33887492,33934391,33992090,34042666,34099079,34157636,34200245,34236772,34274218,34317185,34348809,34381910,34468480,34508033,34558831,34646815,34692209,34738795,34816212,34856718,34901884,34939503,34979728,35027248,35120087,35216165,35270709,35315593,35366574,35450595,35505083,35571017,35630136,35698616,35754590,35823310,35943484,35996253,36110806,36154966,36197612,36246512,36281827,36317077,36345816,36394668,36440701,36480336,36520147,36566906,36665573,36702338,36751850,36798953,36880585,36936759,36975243,37025989,37075762,37125916,37178768,37278176,37328128,37380938,37431199,37525174,37581464,37645455,37689263,37739406,37786711,37830766,37879168,37916249,37961872,38007055,38039642,38068957,38109561,38199941,38241660,38291866,38330047,38410161,38453895,38533930,38612492,38656945,38700931,38748633,38791131,38820352,38898167,38937088,38984476,39032000,39081413,39127788,39167980,39213468,39256596,39303495,39353032,39408062,39448344,39656887,39690971,39730633,39767994,39805029,39842089,39874965,39922323,39961709,39998287,40081843,40119410,40147517,40202851,40242097,40291415,40350227,40396798,40491250,40536465,40628997,40717263,40802398,40838796,40878545,40917459,40996190,41035684,41073881,41126025,41174534,41225235,41268594,41318085,41462841,41506466,41553348,41600167,41765406,41811779,41849731,41944983,41991831,42041033,42083135,42124516,42163740,42215352,42266032,42316306,42362862,42419099,42522758,42574874,42622679,42674830,42720204,42763533,42797035,42838655,42892904,42935261,42967546,43052896,43098125,43149506,43224655,43262537,43344948,43388485,43424711,43501484,43581524,43620516,43665515,43705148,43751034,43859324,43897379,43946775,43990157,44035001,44075459,44133908,44172662,44215020,44300256,44343428,44397430,44437811,44480506,44515552,44559055,44612872,44652494,44761295,44813700,44855197,44888006,44935493,44986552,45029323,45082893,45129347,45187707,45238038,45293338,45337136,45376200,45511520,45584759,45636577,45681978,45734726,45891851,45921679,45956360,46044644,46119030,46166868,46226015,46327572,46367775,46400476,46435920,46472549,46566988,46619773,46656669,46699013,46736396,46826766,46862361,46905723,46945049,46996504,47039094,47080466,47162796,47211052,47247707,47291716,47338097,47390877,47433355,47471478,47514850,47558781,47602897,47690048,47735825,47831202,47869638,47969175,48005501,48046119,48175887,48211662,48252854,48285976,48323809,48369711,48469012,48547570,48586299,48636525,48685006,48720333,48818305,48868535,48914792,48962054,49016063,49066674,49107425,49154467,49197787,49295123,49337861,49382426,49426598,49567908,49640443,49711843,49785484,49848906,49945307,49987145,50076202,50111622,50209294,50255962,50296989,50427599,50470431,50528229,50582843,50692590,50741445,50797526,50851592,50898800,51058387,51155683,51252566,51301394,51381011,51433191,51479414,51542442,51594543,51681940,51721678,51761574,51867622,51912203,51971242,52021869,52153257,52236603,52319518,52362996,52414687,52455098,52502563,52547755,52609532,52727591,52791629,52891133,52947105,53000009,53049486,53160163,53202595,53298859,53341816,53390101,53440053,53485981,53523952,53566242,53612434,53705786,53757540,53806797,53866781,53966061,54067896,54119246,54168996,54219131,54276977,54334196,54385284,54441296,54497718,54595658,54651228,54696063,54757635,54877563,54923914,54975102,55054490,55094249,55135840,55196753,55248501,55301472,55360132,55473384,55530069,55581358,55666069,55759392,55809197,55849582,55896708,55939569,55992811,56038936,56085882,56172659,56280455,56327207,56427430,56476008,56533891,56680157,56725156,56779911,56832979,56902947,56967393,57034533,57079448,57128308,57190630,57261218,57330052,57534611,57632889,57685815,57780999,57845254,57957272,58005833,58143580,58274455,58328327,58376815,58483670,58532905,58571807,58622647,58668703,58835218,58885383,58955464,59093790,59139676,59187129,59237476,59289153,59325806,59360422,59400290,59444967,59480926,59648470,59697803,59750997,59791948,59832484,59881008,59974878,60056130,60109081,60157813,60187212,60230871,60390927,60524282,60592311,60771604,60812602,60861292,60905700,60954144,61011179,61071266,61180503,61225897,61259559,61294705,61332423,61376390,61419196,61463118,61506476,61551470,61636306,61677368,61804729,61840482,61889046,61939303,61984587,62031729,62075557,62104107,62150450,62199340,62244183,62393249,62442343,62480551,62526359,62573021,62731664,62772366,62802623,62846761,62892675,62932680,62977341,63030431,63083359,63138985,63245011,63292732,63344024,63385658,63484635,63534835,63572309,63604975,63611092,63622853,63634175,63639025,63644124,63661371,63714924,63770141,63818631,63863703,63911705,63961717,63998168,64025885,64049303,64077521,64119590,64158363,64197887,64284282,64356756,64413036,64444509,64482819,64523089,64563758,64605916,64651366,64739154,64777701,64820650,64862586,64909625,64953424,65038507,65143939,65236787,65292434,65342139,65462147,65516033,65555125,65723390,65800165,65863361,65912379,65977600,66025708,66075778,66127077,66176167,66223180,66278609,66378974,66427848,66468820,66617693,66737034,66777681,66825433,66869995,66925047,66980947,67032858,67082570,67128532,67173847,67223867,67271280,67321135,67358451,67402491,67508679,67610783,67666916,67824850,67868270,67954982,68001758,68047452,68135579,68179729,68218089,68267161,68366501,68420799,68473380,68527206,68581301,68638406,68694772,68748547,68855597,68903031,68953533,69076300,69119297,69203562,69341739,69380305,69418104,69459743,69534372,69569832,69600749,69643809,69683083,69771418,69809317,69840675,69944677,69995681,70081733,70127561,70183568,70230197,70274559,70352372,70388712,70421550,70457837,70502525,70533806,70568207,70599951,70675528,70713518,70748801,70833823,70875970,70906939,70941912,70982421,71017102,71058062,71110278,71154890,71198778,71241579,71282762,71320324,71390390,71446294,71502600,71579773,71621384,71660364,71699578,71746210,71842213,71920710,71975469,72026596,72084645,72156766,72228600,72283003,72375962,72473777,72510750,72594157,72634327,72674650,72714857,72789517,72827364,72911300,72999431,73044276,73178867,73224299,73266266,73313488,73411303,73514621,73564037,73609853,73649933,73722831,73859865,73907172,73986136,74026583,74077775,74128308,74330957,74376208,74457132,74502730,74542950,74585189,74638518,74677393,74725445,74761465,74810351,74935050,74975457,75055509,75144479,75261344,75302353,75399011,75450088,75496950,75540040,75577697,75632165,75701424,75750335,75798764,75923535,75963013,76000757,76050768,76093201,76132912,76177829,76222087,76267691,76319002,76413227,76455735,76494537,76528888,76615764,76650257,76685725,76717067,76758214,76800892,76882905,76917122,77140693,77187529,77231991,77320697,77360303,77407394,77450233,77497737,77544216,77639591,77704681,77767531,77834840,77938600,78024056,78070634,78127640,78177082,78279102,78331719,78430162,78477314,78521139,78571057,78616189,78662172,78700592,78726734,78761493,78805707,78849805,78903695,78951879,79032342,79077403,79128322,79169636,79219523,79257499,79332669,79377051,79422508,79454504,79506274,79556559,79601472,79730064,79774907,79857877,79877006,79985144,80086451,80204450,80262925,80319409,80382074,80443513,80496146,80556968,80613715,80656070,80707683,80754500,80847922,80890255,80986017,81030840,81070520,81122121,81158395,81245951,81294744,81389119,81434730,81481967,81537212,81589248,81638487,81693524,81846684,81908985,81963516,82014611,82060794,82096733,82187978,82238683,82292285,82377301,82414346,82448146,82493455,82537688,82640238,82862286,82923514,83031817,83083413,83142186,83202260,83253110,83339740,83384668,83422353,83468442,83512514,83594788,83687348,83763359,83812746,83904835,84005216,84047727,84098606,84141053,84189352,84243103,84284757,84327515,84391720,84456203,84586620,84633265,84685977,84792043,84842126,84982430,85025481,85096245,85183573,85230926,85367194,85410273,85494540,85560034,85592036,85627308,85710908,85744461,85827120,85854617,85917628,85950556,86054394,86115084,86227473,86266881,86308212,86337392,86411447,86459559,86496997,86582532,86623337,86664453,86696992,86736910,86964107,87059469,87106421,87146944,87182693,87264407,87322036,87425723,87484590,87533452,87588299,87634118,87691267,87825637,87863220,88026909,88066982,88107756,88162943,88217844,88279240,88386487,88447309,88505367,88563474,88610827,88661091,88710352,88782230,88842501,88902269,88955312,89000867,89046404,89086348,89127135,89217263,89257228,89294467,89344398,89395701,89448617,89502138,89563953,89611873,89758629,89804495,89847491,89943697,89982963,90028890,90077356,90111187,90149425,90268792,90312830,90383273,90422173,90462287,90502146,90627052,90658160,90696821,90729280,90761342,90803734,90843116,90882737,91011340,91057079,91099509,91146824,91242175,91304488,91362628,91414326,91460829,91503015,91586419,91632773,91681177,91722776,91798250,91837362,91886606,91934244,92024136,92119554,92155746,92199761,92240336,92277818,92312747,92362915,92411469,92456171,92511042,92573180,92623924,92670400,92713924,92768701,92810743,92848794,92936737,92974297,93012016,93050800,93139901,93245226,93286376,93323533,93440477,93503011,93553890,93599370,93637307,93717108,93753682,93849820,93924636,93973392,94016214,94093646,94171089,94284858,94331051,94387387,94430412,94469004,94514199,94563143,94607880,94702074,94792254,94833122,94934690,94977574,95023770,95116278,95151767,95188818,95238521,95290212,95335460,95415932,95453922,95499563,95542473,95574507,95647008,95714377,95750678,95792195,95831206,95864697,95891416,95950556,95980024,96006113,96078678,96123301,96155751,96193226,96249554,96295658,96354698,96411220,96465295,96585565,96648742,96714109,96764751,96805333,96855782,96911124,96966559,97015858,97060964,97111388,97156094,97222407,97342380,97407610,97465737,97514753,97563357,97609636,97657273,97700865,97751747,97849230,97947760,97993064,98170196,98265967,98309419,98352491,98397571,98444320,98484984,98523034,98568328,98614950,98665486,98736514,98762860,98803883,98841223,98882927,98920705,98951896,98982190,99083715,99112422,99148712,99225971,99299746,99331205,99368622,99410917,99434140,99474303,99574123,99613714,99702241,99746890,99777668,99824209,99874153,99925829,100098308,100166795,100280875,100407985,100453400,100494104,100533896,100571075,100663883,100705354,100744625,100792178,100840058,100898541,100957461,101079007,101122380,101162069,101209882,101262768,101306776,101353164,101401159,101443922,101482240,101558557,101666500,101708310,101743994,101786000,101824491,101864378,101910423,101993515,102029644,102064962,102135145,102182710,102271046,102314669,102361444,102410036,102491933,102589451,102620510,102663507,102702114,102785185,102923992,103023283,103078680,103121045,103165891,103215943,103250613,103295287,103335790,103370704,103408192,103448598,103488492,103568587,103605615,103642530,103683651,103719972,103774428,103825892,103864951,103901939,103938828,103994168,104039195,104077060,104114750,104150988,104190577,104264029,104294789,104331884,104369044,104406867,104459761,104594624,104631505,104670075,104708382,104740540,104773074,104809749,104856865,104891092,104938803,104979086,105055177,105090850,105127442,105192432,105275801,105354915,105388837,105417781,105456574,105495140,105540707,105639154,105714154,105739700,105781088,105813735,105854360,105900387,105942822,105985712,106026941,106070195,106115104,106181302,106217881,106285738,106326780,106369083,106446543,106512194,106589400,106625940,106652204,106682022,106721400,106760896,106808803,106852462,106941318,107037416,107073437,107108006,107146376,107193722,107240259,107288535,107334983,107385731,107448116,107521043,107570782,107623207,107710137,107752217,107803333,107884363,107918819,108003452,108131089,108170892,108213837,108255161,108291301,108330152,108366620,108409763,108562441,108609111,108655033,108690126,108728627,108758051,108797995,108843900,108889127,108935569,108981695,109028362,109066731,109104539,109141574,109223200,109259064,109334999,109372390,109437052,109471883,109505140,109540684,109576925,109618559,109700930,109729987,109813010,109854861,109889221,109927086,110000596,110039021,110077751,110120665,110198930,110237853,110277422,110314769,110376855,110447328,110493015,110525841,110560745,110597298,110639585,110675616,110716802,110760505,110802534,110838703,110871243,110933267,110966096,111004145,111038379,111073076,111104385,111129053,111150024,111177434,111202064,111236766,111269277,111302424,111330368,111370615,111420998,111459104,111495176,111533874,111575914,111620931,111661710,111695934,111728767,111761068,111807859,111858911,111905979,111950692,111978995,112009831,112038273,112066812,112095246,112128232,112160860,112193040,112220547,112248013,112283058,112313712,112526399,112558019,112592004,112617208,112662652,112691474,112806296,112839317,112907759,113008064,113044780,113082171,113108685,113151299,113198563,113244418,113285909,113318840,113354375,113388046,113418574,113441991,113471811,113500484,113527319,113561806,113630385,113664067,113686197,113716509,113746250,113774092,113812897,113847762,113889228,113933651,113973270,114000425,114022946,114051002,114079018,114101311,114136405,114166154,114195692,114221765,114262351,114294059,114457899,114497396,114523062,114544536,114579004,114616923,114752791,114774439,114823936,114848968,114942160,114979319,115011854,115048168,115087313, respectively;

The positions of the SNP loci on chromosome 14 include: 19004241,19014220,19026535,19040054,19048893,19080173,19109812,19265588,19435427,19484909,19744897,19820800,20113335,20207317,20245067,20280927,20318112,20378549,20411078,20486786,20520675,20590513,20638141,20672763,20711469,20758366,20805662,20839307,20881138,20919319,20957923,20993439,21032595,21074683,21107126,21181461,21212108,21241596,21311645,21349932,21401495,21477616,21515528,21552835,21597014,21631457,21680716,21727988,21773480,21813156,21860866,21968504,22012216,22077177,22108653,22144071,22188829,22233399,22310189,22411486,22440258,22476144,22516578,22545241,22586343,22616049,22652274,22718330,22751334,22786996,22835396,22880443,22926919,22970035,22995074,23074899,23113817,23210109,23242980,23305751,23345287,23391086,23436369,23493504,23543881,23660058,23735900,23791520,23845461,23882350,23905751,23948928,23999814,24109696,24154702,24184084,24220391,24252018,24291771,24338431,24382212,24421676,24461507,24513520,24714264,24754046,24800577,24839897,24888697,24954202,24995331,25052827,25149580,25243751,25285846,25345898,25390661,25431699,25482474,25537228,25577942,25620327,25659076,25736541,25769922,25803217,25849033,25887349,25923648,25973239,26016909,26066679,26107494,26147126,26188556,26237458,26294886,26356384,26476094,26520201,26558679,26599561,26703176,26752004,26793599,26829859,26873787,26927111,26992064,27051340,27163828,27205328,27315523,27376505,27440457,27541667,27624981,27731432,27822638,27867818,27915411,27973832,28066265,28118949,28167755,28259669,28297700,28320904,28366190,28416025,28459002,28504321,28547260,28593927,28636781,28689161,28739646,28840617,28880796,28930035,28983650,29022242,29061653,29098755,29147346,29192618,29303677,29430305,29541494,29655520,29719646,29772059,29836773,29900195,29956060,30003024,30085236,30118463,30162013,30215086,30326858,30375428,30425562,30534152,30583474,30633717,30683130,30741045,30803862,30854448,30911690,30972850,31023554,31073297,31120787,31179594,31268748,31309814,31353247,31397476,31486706,31528062,31585174,31631771,31685061,31729807,31773068,31822149,31872749,31914971,31959641,32004528,32052978,32104842,32193674,32232732,32276011,32310250,32352633,32396952,32426604,32520038,32590304,32651796,32765622,32812511,32848218,32893342,32967586,33013596,33063524,33111792,33162621,33207400,33248858,33289463,33325196,33412626,33453647,33496978,33548252,33590891,33633155,33679447,33729340,33777735,33814021,33850155,33898971,33942623,33990830,34075510,34125226,34165057,34210238,34257510,34306451,34347610,34393602,34433221,34468721,34506408,34548054,34592274,34642612,34718605,34802241,34876199,34917022,34952887,34989817,35044556,35092927,35135607,35176730,35210156,35256361,35302350,35342838,35385655,35424436,35570816,35618360,35658638,35709009,35760054,35801346,35871444,36045942,36117545,36186182,36247283,36306407,36367009,36417777,36454580,36500842,36545461,36584219,36680746,36727174,36783877,36841159,36891135,36945392,37001352,37045498,37091499,37132248,37223166,37263178,37307414,37394567,37441176,37487132,37575793,37617232,37665045,37779265,37829448,37885731,37948621,38006519,38061336,38121370,38174634,38212551,38269967,38318172,38376573,38488659,38544470,38591024,38678056,38736784,38782096,38863987,38947357,38994672,39043263,39087408,39136292,39187312,39242720,39300780,39351589,39405310,39452687,39554078,39635469,39667661,39758196,39792555,39886855,39991127,40046317,40155469,40196876,40252768,40306839,40350587,40402365,40447058,40503709,40550580,40587407,40677483,40788882,40843130,40884074,40919556,40954725,40989521,41019126,41049211,41076770,41112714,41157196,41205566,41255667,41303944,41338165,41430022,41474756,41506225,41527131,41568836,41602337,41678659,41727607,41771455,41819091,41873129,41917702,42029085,42092402,42153162,42198410,42320790,42422532,42472305,42509986,42547285,42589387,42631920,42679654,42719876,42758259,42800019,42872292,42914536,42957137,43048131,43093153,43135501,43188383,43233288,43279961,43330160,43379414,43422101,43464405,43501589,43540246,43574709,43615856,43664043,43723085,43776163,43823570,43868549,43912336,43957047,44003136,44053466,44096772,44140830,44192700,44242704,44339448,44402502,44444697,44491754,44536876,44581257,44629572,44669124,44725022,44770916,44821980,44879327,44961819,45001676,45042709,45051733,45094980,45145699,45191205,45245255,45307793,45364920,45416026,45480376,45540960,45612664,45675772,45741270,45816340,45889010,45961699,46065940,46125095,46178308,46230859,46275487,46322950,46352072,46389898,46432793,46475174,46516539,46606306,46653857,46697082,46742642,46791230,46837024,46888821,46934687,46975411,47022731,47080771,47128019,47218924,47266095,47323422,47388474,47431531,47478505,47567007,47612161,47725989,47768412,47808059,47854101,47898038,47945667,48006771,48064755,48117246,48242149,48284452,48355496,48398664,48439631,48489272,48568453,48642419,48701173,48750194,48843135,48900342,49021398,49075229,49169314,49228155,49281568,49370571,49464841,49513651,49562370,49648421,49699543,49748071,49789020,49925776,49973195,50022044,50105684,50151115,50212718,50262257,50310018,50357061,50438798,50478492,50560177,50640128,50765502,50800588,50846269,50895137,50997546,51058234,51107737,51185923,51228655,51278057,51318288,51354682,51391006,51431223,51509390,51549634,51595335,51638966,51689905,51739293,51784942,51910661,51956718,51997580,52044247,52082661,52129311,52180569,52222161,52270982,52350131,52395480,52428759,52472795,52501902,52529083,52570890,52614501,52645705,52675539,52756594,52798092,52838084,52883981,52938919,52992462,53037128,53151341,53209963,53413208,53551106,53613974,53663595,53704749,53754559,53797644,53827368,53881839,53933920,53984191,54043150,54102009,54153107,54194185,54240454,54299289,54392613,54441614,54491149,54547435,54592962,54646469,54689343,54754604,54804507,54843017,54884511,54936346,54994826,55053210,55094425,55143117,55185030,55268294,55316232,55367416,55405427,55454956,55507628,55561232,55726425,55769883,55810831,55849213,55895104,55923210,55956526,56038180,56088860,56136040,56181300,56221819,56307085,56348839,56387545,56426945,56474458,56518856,56557345,56603088,56660107,56696472,56743073,56871878,56927344,56963182,56997940,57073932,57119945,57162880,57207836,57342832,57381105,57427625,57473275,57555827,57708608,57771773,57829026,57886005,57938118,57980417,58022794,58107933,58144371,58226607,58275992,58323765,58363425,58433026,58517384,58566228,58685833,58741618,58795687,58931528,59060102,59112475,59157919,59241220,59282645,59325631,59366252,59422619,59460548,59501704,59543107,59582631,59624317,59678626,59777688,59827386,59863176,59907789,59956113,59995842,60045199,60093819,60165473,60269379,60328427,60402519,60464145,60520579,60675060,60779031,60842391,60917496,61031284,61085141,61138847,61182085,61254110,61321331,61384863,61450658,61575640,61616263,61654643,61693613,61731920,61835400,61879332,61919216,62064257,62112982,62299007,62350814,62397867,62459095,62502340,62539699,62677341,62758340,62803697,62888268,62919811,62989803,63034299,63079703,63105687,63147993,63199660,63248290,63343862,63493537,63542044,63598207,63642791,63743564,63783052,63825672,63863816,63909290,63945101,63982105,64067436,64109428,64164425,64214837,64266131,64312318,64355806,64403654,64497929,64541600,64587401,64687710,64724993,64780116,64832600,65030190,65089468,65135586,65182316,65232095,65268451,65307246,65352423,65437562,65491804,65549089,65599443,65635440,65720143,65762051,65847351,65896041,65991737,66049184,66100768,66152004,66205649,66253437,66296087,66339725,66388000,66431896,66475442,66517776,66563491,66675364,66729277,66788116,66846217,66909881,66957196,67013165,67058902,67059238,67106634,67150673,67206082,67257994,67311322,67373863,67431696,67495340,67541422,67601861,67656917,67708717,67758504,67805014,67855598,67905423,67987253,68035175,68073358,68115459,68161356,68206891,68248774,68298812,68353879,68407385,68464273,68592542,68641096,68705020,68754824,68799303,68895693,68941989,69039588,69074606,69118241,69158040,69198917,69232191,69275310,69390185,69432044,69476895,69521338,69575941,69635175,69687045,69778816,69822927,69866847,69924302,69971627,70026853,70084011,70136653,70188636,70233186,70276933,70319261,70362890,70401755,70442987,70488431,70579715,70615594,70650834,70693175,70732443,70813520,70857022,70897737,70940591,70990385,71043556,71085059,71169310,71212158,71253992,71330918,71373580,71422789,71469015,71525765,71586319,71628063,71663816,71707781,71829782,71892566,71963428,72032351,72109945,72185653,72245203,72293012,72334597,72376451,72421334,72465383,72496823,72582474,72630071,72705363,72738833,72778834,72816180,72906389,72950438,73027000,73064446,73109766,73158413,73205950,73282419,73318473,73356299,73392938,73429916,73466280,73556416,73602899,73649732,73728386,73770312,73824215,73867487,73908201,74005488,74050321,74087595,74131122,74168431,74216606,74299507,74373609,74416646,74533691,74574163,74615378,74651913,74691932,74726009,74756776,74793881,74841467,74886168,74931153,74982212,75075785,75182315,75241606,75307588,75356799,75450199,75546250,75603239,75654933,75750466,75871657,75917207,75957952,76038388,76087014,76139134,76258581,76321510,76372254,76429157,76475949,76523191,76570684,76613678,76656460,76741336,76815889,76858983,76899467,76932061,76973328,77006765,77083749,77126240,77151803,77186640,77229532,77281882,77354554,77397668,77440625,77480599,77553906,77597268,77637976,77697637,77738918,77788749,77833808,77880104,77925154,77958858,78055036,78089870,78162617,78203650,78244635,78282771,78356245,78401921,78534475,78571385,78612850,78698154,78739383,78825609,78874209,78919999,78962030,79004001,79059667,79105473,79252797,79296488,79356051,79449663,79490575,79570322,79621431,79660882,79711725,79761736,79827037,79877592,79935212,79980316,80024861,80068984,80108238,80157170,80203080,80301514,80390370,80474190,80533865,80584555,80639349,80694103,80770565,80837785,80884583,80936298,81039132,81092103,81127849,81174506,81226088,81280664,81330921,81373372,81416915,81546732,81586470,81696252,81754764,81846334,81890783,81930632,81984211,82037158,82070720,82115590,82154566,82241899,82280449,82332888,82386690,82432678,82477473,82520202,82620849,82708203,82824035,82931168,82980080,83024189,83069532,83115807,83207636,83255356,83286588,83320597,83361570,83402539,83425981,83472053,83515665,83587036,83636576,83692040,83738652,83786594,83890773,83934765,83971295,84013541,84070701,84180897,84226499,84272291,84323330,84370060,84507306,84562548,84603270,84688008,84730189,84775080,84826658,84922787,84975733,85019563,85057698,85152219,85198677,85247702,85302778,85357812,85448144,85590078,85632914,85716135,85757494,85805180,85835554,85850495,85891138,85930269,85978782,86020497,86100578,86135234,86168332,86207286,86242052,86285115,86430609,86458994,86518217,86577671,86623834,86672760,86750434,86827806,86905543,86934182,86975245,87017901,87074975,87135417,87182870,87242598,87294758,87340547,87393296,87450938,87506248,87553025,87645184,87705438,87743893,87784378,87828466,87873861,87916052,87965993,88014118,88062686,88109684,88151708,88193968,88233941,88285116,88330540,88368443,88394809,88423820,88461498,88510109,88544791,88589635,88639955,88718699,88759715,88802133,88849897,88892375,88944331,88984048,89039729,89089485,89151052,89206243,89269127,89423154,89457054,89498009,89531426,89571030,89609980,89655336,89695798,89739386,89779833,89818623,89855072,89929230,89970343,90049492,90138781,90188194,90230779,90315184,90373881,90450846,90488460,90534501,90580303,90610293,90648307,90699901,90738171,90785895,90825718,90913293,90957628,90992743,91039140,91095838,91136964,91181269,91226569,91265601,91304045,91345960,91399611,91450940,91543797,91592036,91680540,91772285,91816479,91857602,91904947,91951338,91993143,92035928,92077878,92119574,92162277,92203773,92297421,92380018,92423766,92508917,92547425,92620047,92658802,92692026,92755472,92797887,92837511,92873893,92910740,93014385,93056912,93099890,93130713,93167758,93209006,93250704,93289821,93333680,93373707,93410415,93456731,93505244,93559288,93600914,93673934,93768589,93806831,93859578,93920767,93972848,94026035,94081739,94139021,94199372,94240749,94287160,94357905,94391699,94432478,94470185,94506299,94547064,94626667,94678228,94735739,94776153,94814039,94843499,94870171,94909051,94939787,94978311,95018592,95054272,95083926,95121464,95143114,95174621,95259000,95288761,95325563,95353389,95383411,95419570,95461154,95502751,95600426,95660684,95708491,95749011,95795387,95833706,95870214,95899197,95930986,95964196,95996319,96030981,96060549,96084904,96116687,96148850,96184969,96223418,96268607,96304178,96395892,96434973,96474605,96562047,96597658,96630854,96667677,96707598,96747391,96794874,96853872,96903854,97062957,97144256,97180875,97254594,97350977,97397509,97446450,97490979,97571437,97608212,97644266,97694239,97747012,97803040,97892795,97933671,97977153,98020723,98126090,98170611,98207691,98240735,98273322,98345806,98411556,98447779,98484983,98557257,98589272,98635154,98670418,98708339,98741998,98775077,98804790,98831026,98867516,98899211,98934144,98971909,99016587,99087085,99165309,99244885,99278602,99318919,99363448,99433568,99471244,99506719,99545932,99658045,99746348,99791631,99866722,99977411,100018442,100046229,100088334,100168462,100210370,100295252,100389164,100472357,100559832,100607779,100655022,100708066,100750084,100796490,100835820,100882998,100980040,101022672,101068210,101106995,101149511,101183950,101231438,101274804,101319020,101364609,101413202,101464984,101509044,101544539,101581293,101650894,101676148,101706307,101752324,101795599,101891883,101934952,101971689,102080283,102129590,102240913,102301836,102346833,102389881,102425872,102516770,102552369,102604715,102653746,102699636,102754257,102803765,102861331,102911988,103001411,103048904,103099176,103144583,103249935,103302070,103362017,103407730,103481561,103526168,103568047,103607031,103636813,103677821,103709151,103866269,103908433,103986086,104035519,104085832,104133392,104172704,104218890,104266997,104315440,104358076,104389231,104424583,104516391,104563758,104611350,104681383,104740379,104767818,104836132,104881564,104919105,104962606,105024514,105063116,105104208,105147219,105231196,105266062,105309599,105346869,105386557,105424199,105468992,105593686,105636112,105776114,105828530,105884961,105929505,105975810,106022680,106051834,106089676,106114658,106148130,106186614,106208431,106234422,106273250,106320953,106334873,106466727,106484048,106517972,106542044,106576854,106604176,106638090,106677042,106710300,106733078,106757831,106773780,106785946,106806761,106822237,106855111,106870367,106879407,106901990,106924739,106941875,106975947,106994922,107018715,107031449,107045343,107070795,107094572,107108755,107150281,107161917,107170018,107179243,107195328,107235114,107256858,107286255, respectively;

The positions of the SNP loci on chromosome 15 include: 20009785,20017858,20033729,20045291,20066842,20084355,20109261,20120757,20137849,20166367,20262236,20412850,20439889,20455929,20471978,20493792,20513591,20540441,20557173,20584498,20605746,20740367,20864117,20886919,21122899,21160981,21922309,21940821,22011563,22299450,22351505,22378655,22402353,22427629,22461786,22491346,22516147,22540799,22569637,22742752,22803850,22829776,22863553,22903717,22941425,22979867,23091321,23190414,23608622,23718659,23752260,23796444,23843033,23921881,23972360,24056556,24091600,24133122,24172569,24226382,24256344,24331296,24357725,24390787,24418868,24444265,24495576,24521262,24561516,24585853,24610877,24635315,24663979,24694918,24740532,24778603,24800794,24825142,24857494,24899949,24983390,25120270,25182585,25231046,25283881,25321029,25366726,25415222,25443773,25478225,25521716,25580637,25640964,25694320,25741011,25779886,25890580,26070216,26110473,26136374,26201756,26260992,26305413,26347929,26390185,26426824,26472365,26523035,26570398,26608213,26695034,26743246,26792934,26835167,26878772,26924444,26962228,27002886,27034320,27063163,27102991,27209075,27264253,27305701,27412400,27461603,27501315,27602224,27644946,27695885,27745346,27778589,27820352,27856075,27891937,27970378,28010462,28052654,28094153,28134674,28173598,28269487,28369328,28430939,28484131,28705226,28962131,29075647,29224454,29263425,29309862,29351982,29391798,29425002,29460356,29511631,29550943,29595240,29721356,29763544,29799511,29846417,29931280,29973725,30072614,30129196,30193097,30282139,30331658,30938533,30998495,31036898,31116585,31315570,31364474,31405422,31440597,31487807,31563438,31607115,31658025,31706416,31747312,31781988,31823590,31872185,31966607,32018274,32069223,32113955,32162787,32211144,32307908,32355086,32400547,32444185,32823831,32990026,33027179,33062903,33092196,33130073,33168360,33203874,33241706,33306996,33333116,33367649,33403988,33465227,33577798,33616345,33663077,33699848,33743396,33779446,33824335,33862539,33941144,34015960,34048707,34080892,34114212,34149427,34180957,34208859,34242369,34277300,34357259,34435998,34603212,34639049,34671726,34725342,34780907,34862151,34876077,34928299,34975679,35010136,35044302,35084122,35126486,35182441,35237294,35287884,35332631,35459109,35503175,35556177,35684068,35734680,35990383,36132971,36227467,36268701,36314715,36357252,36453533,36518642,36567143,36612233,36664355,36707838,36871609,36967086,37017096,37105935,37165621,37267426,37312922,37523136,37563352,37619728,37674816,37728886,37785689,37877853,37933226,38035198,38086227,38136326,38170700,38269523,38318525,38362765,38475391,38618155,38662192,38702126,38741616,38788948,38840251,38904747,38994348,39029230,39063533,39110442,39158933,39196185,39236104,39271677,39305160,39382946,39426330,39465776,39509073,39588417,39621773,39704875,39746294,39790698,39833895,39874092,39920918,40001306,40081691,40139851,40181575,40228178,40270655,40359569,40400135,40446293,40550842,40593776,40643717,40691554,40784859,40835667,40871119,40912913,40965452,41012180,41060774,41157497,41257227,41351332,41407912,41458024,41497746,41542681,41601148,41663900,41789091,41833029,41880619,41936997,41994315,42059002,42122842,42168373,42212184,42262847,42336450,42377654,42416720,42469260,42571166,42614339,42652961,42734482,42797305,42849431,42903816,42969116,43021628,43150834,43303380,43379773,43452179,43579740,43694826,43749151,43912372,44020649,44076044,44137510,44199681,44265203,44329256,44396035,44445608,44504115,44566788,44660646,44738326,44813274,44878370,44950097,45018637,45106447,45156734,45209094,45255937,45308473,45391499,45437272,45484557,45524936,45565159,45609865,45655354,45719359,45762756,45834294,45903472,45948384,45986665,46019231,46073591,46161483,46250715,46289278,46380008,46437802,46484904,46525152,46574136,46626779,46678078,46773567,46822494,46869577,46899542,47052778,47108711,47164930,47217699,47327657,47367066,47390356,47428854,47492259,47539068,47591464,47640608,47678132,47717864,47765152,47814878,47868142,48023870,48075941,48114589,48156544,48262588,48314553,48379368,48445505,48523822,48567525,48615918,48662483,48704790,48745479,48784981,48835420,48893649,48945759,48992954,49052785,49163102,49264185,49326412,49381897,49436289,49615783,49677023,49734968,49786481,49843340,49895046,49947688,50053150,50106638,50153674,50209467,50258166,50309413,50365389,50488859,50531372,50581882,50629314,50670121,50716635,50811906,50848271,50889693,50928155,50964964,51049989,51139135,51232051,51347471,51403444,51456110,51502082,51547931,51589285,51629104,51709365,51773357,51838794,51895072,51944563,51993004,52040379,52139416,52185734,52233754,52384454,52461760,52507009,52598500,52648468,52876523,52929465,52982876,53028304,53071207,53124885,53172666,53206030,53242242,53333746,53375933,53410566,53456044,53500433,53536741,53579889,53622101,53709656,53762511,53803160,53847083,53925277,53964193,53998829,54031981,54068345,54146936,54183560,54219071,54251812,54287662,54333143,54372638,54479054,54518159,54550097,54631840,54672830,54762105,54800092,54846070,54895577,54934393,54965345,54998764,55035232,55071943,55111984,55165718,55205011,55281093,55325407,55367434,55408162,55454917,55496111,55534998,55578596,55630984,55715606,55763693,55812332,55849196,55893245,55937709,55985033,56028539,56063330,56185654,56232745,56270335,56314041,56350171,56445142,56502899,56551416,56603043,56650179,56746241,56786498,56831184,56878521,56931536,56994682,57052565,57162093,57225443,57268242,57313706,57359225,57401025,57448869,57530889,57574426,57612424,57651069,57678577,57746787,57814888,57851611,57884119,57923325,58009061,58047036,58082071,58121759,58159378,58196396,58240333,58275662,58313104,58359023,58407633,58454693,58492885,58535132,58568536,58600857,58618756,58717319,58906516,58964534,59015452,59062274,59112066,59163291,59281601,59335584,59386148,59420155,59464039,59503618,59537891,59571257,59611833,59720795,59781145,59868938,59905351,59943142,59978808,60117125,60154067,60238633,60399135,60437105,60469341,60504770,60541189,60582360,60611068,60650120,60691876,60737591,60793259,60835324,60891946,60933297,60979063,61026975,61106118,61142605,61176249,61210890,61259740,61289852,61366723,61455893,61499751,61557879,61603364,61650542,61693796,61774847,61854922,61897851,62036600,62080633,62218571,62326957,62415736,62466228,62505033,62553170,62643007,62729177,62766315,62809360,62852046,62891243,62932009,63052883,63100090,63138018,63176279,63209570,63243050,63279973,63312474,63352140,63388941,63466745,63521977,63576758,63621668,63665847,63708260,63751020,63792074,63901256,63966294,64024250,64131281,64170690,64248095,64292701,64379339,64428564,64480791,64538191,64597046,64701727,64753954,64807362,64863640,64905865,64954551,65016121,65061533,65107606,65144099,65181201,65227473,65260961,65307470,65355451,65420321,65489196,65542140,65588561,65633052,65677093,65771454,65815021,65927214,65993887,66050110,66100685,66153061,66211888,66260480,66344358,66390531,66430422,66470510,66506531,66546725,66637027,66678437,66716402,66761130,66847967,66922012,66953084,67031519,67074390,67114547,67149172,67191056,67269804,67305761,67392755,67433972,67477450,67594515,67702988,67770789,67828463,67878098,67925836,67984818,68039921,68095018,68144417,68190111,68227960,68365718,68414104,68519382,68565801,68614019,68650384,68680265,68723253,68759581,68854794,68900867,68949858,69023691,69057667,69106817,69161349,69217713,69285470,69345393,69389174,69451026,69518392,69574387,69612966,69653225,69694535,69750125,69802331,69861550,69905087,69987236,70041576,70083899,70122639,70165386,70206446,70297855,70346493,70395174,70440058,70476910,70516351,70558530,70593591,70726544,70808567,70949501,71011286,71071918,71108369,71164936,71252176,71411682,71473904,71573087,71612115,71656723,71698548,71737002,71781300,71818982,71853904,71925612,71966949,72009597,72043372,72086048,72135257,72196139,72252917,72309170,72488559,72528136,72590339,72635829,72684179,72755136,72873978,72971401,73069243,73121225,73179774,73238227,73283449,73342025,73396825,73516933,73576750,73629746,73691207,73753429,73820545,73949210,74006632,74044153,74089120,74168228,74256608,74306722,74470761,74564659,74603385,74660786,74706730,74738348,75014279,75052914,75101530,75165083,75225585,75385883,75486764,75546439,75635460,75771103,75834363,75914157,75974515,76035734,76134057,76180465,76281852,76335901,76389945,76428815,76477058,76528191,76574265,76622903,76734232,76841562,76910031,77020900,77081723,77136588,77191654,77408761,77477012,77539826,77678273,77739936,77800541,77836459,77875425,77916745,77965404,78004806,78046110,78086573,78127524,78198315,78226348,78267947,78353554,78405659,78503912,78540077,78579132,78622333,78669658,78717949,78763617,78813037,78924517,78966351,79021445,79051759,79082264,79121209,79153733,79186952,79224837,79261557,79292391,79341353,79387936,79477496,79514200,79555005,79595249,79633672,79665247,79706693,79747051,79826743,79864676,79904983,79951653,80030883,80067102,80105784,80185162,80312547,80357904,80405098,80450690,80493461,80532340,80612215,80652469,80682796,80771173,80864856,80904460,80948184,81040885,81086069,81173671,81217578,81263395,81307898,81354359,81436280,81486054,81524224,81561182,81604871,81701951,81803947,81856836,81907632,81954101,82053265,82109979,82224007,82262309,82314409,82358722,82399694,82439576,82493243,82550071,83224831,83269740,83320912,83387752,83440810,83497918,83538911,83601380,83776182,83848978,83913564,83981141,84055510,84234524,84284040,84335453,84381369,84485472,84539420,84581004,84637928,84703340,84766544,84857778,84946970,85083922,85142543,85193727,85245310,85292361,85346632,85436802,85462455,85491665,85538070,85580295,85627175,85673582,85717955,85824802,85866890,85905576,85944107,85996443,86041970,86085543,86123170,86159630,86198755,86237643,86318361,86352859,86380973,86453361,86492011,86524934,86556612,86642225,86739476,86778360,86815799,86847227,86888271,86929497,86976755,87069407,87117897,87154938,87226605,87266546,87337017,87378003,87418645,87457019,87495485,87531283,87603764,87646852,87722249,87758448,87805103,87898302,87984866,88017070,88062471,88107851,88148486,88227192,88272680,88322036,88365214,88407573,88449778,88490213,88541425,88592700,88636875,88680684,88724452,88766993,88815561,88862322,88953463,88999024,89090757,89143714,89180794,89222162,89263591,89308963,89356461,89391160,89462618,89531932,89572340,89605286,89691687,89768727,89814106,89855576,89878417,89920519,90009454,90057758,90099065,90138406,90190929,90235111,90277243,90308979,90342353,90387578,90434888,90475551,90513549,90561690,90602877,90682708,90713648,90826580,90898907,90937051,90983465,91028021,91067481,91104288,91145289,91185485,91222540,91269593,91310822,91341057,91371314,91450693,91559602,91589719,91622472,91673109,91710476,91752355,91796812,91836948,91919030,91965537,92011732,92042721,92126997,92209880,92299767,92331158,92374710,92422133,92464119,92540556,92601768,92646092,92720497,92790405,92835978,92873985,92920058,92953675,92997327,93041240,93078264,93111869,93146567,93178329,93280418,93317290,93351027,93392788,93434062,93575176,93604007,93643221,93676041,93705070,93741544,93783032,93813639,93841222,93897330,93937451,93964637,93995487,94027804,94069733,94105132,94144735,94229530,94301858,94338254,94372098,94414757,94462966,94511926,94596751,94644514,94681738,94725455,94768663,94880129,94914389,94954144,95004997,95044568,95123489,95167562,95204773,95245094,95280165,95318586,95362829,95456581,95502373,95542075,95601463,95651523,95699770,95784181,95825194,95861536,95960583,96004066,96050881,96129853,96177695,96284424,96395336,96536982,96660990,96694295,96732543,96773679,96857204,96996477,97043656,97098189,97161115,97214163,97267936,97317814,97362473,97400041,97514782,97556475,97596360,97637111,97696253,97743100,97787009,97823490,97874036,97921375,97967932,98021728,98060722,98109510,98149309,98230998,98271394,98346923,98372650,98412718,98451542,98488191,98523072,98598400,98624655,98658897,98692434,98771760,98807205,98839942,98872562,98898674,98935537,98972794,99015763,99056533,99130268,99166414,99244873,99317832,99362323,99511793,99548452,99583598,99618168,99655273,99693800,99889146,99941988,99979013,100153115,100266779,100296882,100334872,100370547,100401949,100444736,100514417,100545491,100579095,100604126,100637668,100663806,100693451,100754485,100786248,100811344,100841570,100874935,100953026,101026930,101058351,101089241,101154771,101198983,101233761,101268731,101319026,101358941,101400000,101440390,101482343,101592567,101651870,101689741,101726780,101770768,101806754,101841775,101878924,101911343,101938231,101968067,101999742,102032358,102065780,102133491,102173871,102229740,102278108,102316382,102364744,102430996, respectively;

The positions of the SNP loci on chromosome 16 include: 91841,125757,150839,187676,216742,237453,282890,318413,351517,390810,423750,501638,541821,619483,653739,690552,736447,785075,820888,847980,874855,896901,916328,943656,965589,988348,1003849,1027689,1060684,1086911,1115904,1142383,1171634,1214174,1241146,1261282,1290101,1350475,1383911,1419709,1452568,1491322,1546948,1589083,1638820,1690433,1744736,1802164,1865751,1891218,1919768,1956295,1995371,2028914,2072870,2108330,2144176,2181818,2241568,2296982,2349111,2441501,2492029,2555237,2648651,2734721,2785759,2838395,2880118,2914335,2949272,2983795,3013712,3104636,3134633,3184170,3214964,3249696,3282680,3306602,3357679,3433900,3475699,3511712,3546405,3585026,3633105,3676927,3718387,3760882,3873814,3928713,3968696,3998470,4033012,4068230,4104069,4141619,4177368,4217235,4252647,4283042,4386814,4435357,4479836,4531814,4580599,4622102,4669584,4700525,4734415,4778564,4816532,4859530,4902109,4938727,4973515,5043468,5077865,5116161,5147093,5177282,5205825,5236786,5270521,5298201,5328472,5360351,5393797,5423618,5454823,5483231,5513523,5572974,5597823,5648168,5673958,5702689,5731182,5759269,5784292,5816693,5841952,5870606,5896437,5928709,5958620,5992592,6021830,6053833,6088595,6116226,6137579,6167345,6193147,6260759,6286800,6314330,6377202,6414671,6442805,6472666,6502271,6530050,6556442,6584600,6636967,6659626,6684808,6705112,6727498,6745198,6786048,6811881,6835857,6877186,6898414,6918394,6936288,6995615,7015971,7037868,7060955,7084679,7101976,7122024,7144056,7169407,7194399,7216439,7238357,7255778,7276185,7330246,7363474,7427283,7455781,7477170,7504854,7532073,7558486,7588686,7617135,7642236,7679036,7712321,7744105,7768719,7794894,7817999,7852342,7876499,7913432,7944591,7977691,8004007,8033772,8064771,8093956,8124559,8155821,8179909,8239893,8272084,8300393,8380620,8407937,8434514,8460186,8486397,8539862,8563317,8587714,8608656,8695530,8729275,8754820,8781554,8812192,8840025,8867408,8899358,8933734,8960661,9004266,9047756,9090886,9124265,9155783,9189018,9253101,9316812,9344950,9382576,9417495,9463143,9504839,9539908,9574375,9610404,9644113,9684712,9720593,9757356,9795074,9822323,9866608,9958756,9999005,10043512,10086811,10129861,10161273,10191369,10216343,10249323,10289857,10361294,10394500,10428947,10460838,10500760,10541189,10589144,10620021,10719912,10745264,10770645,10797547,10830285,10870002,10912615,10951268,10994072,11036624,11078338,11161503,11204330,11244513,11281374,11313051,11346725,11374756,11412448,11445116,11474424,11495990,11519750,11550228,11579259,11604073,11735490,11768714,11808806,11897523,11933262,11976653,12019671,12061134,12103297,12148055,12184199,12256742,12301727,12334385,12369300,12408759,12445436,12475876,12506066,12534664,12563957,12600624,12627939,12643387,12653647,12663674,12676983,12707218,12718306,12736903,12780739,12824745,12860232,12895505,12926493,12959260,13023388,13064265,13102532,13137114,13175378,13262039,13383328,13431731,13467613,13504103,13539137,13622857,13659177,13695662,13729075,13761373,13793671,13825081,13860819,13890494,13920635,13949084,13983589,14020218,14063605,14101025,14141090,14198650,14251359,14305715,14354661,14400189,14442098,14494594,14578772,14648112,14716618,14905940,15073850,15134375,15193672,15322619,15483802,15523378,15575217,15684491,15738657,15826666,15902715,15931151,15964476,15992538,16105482,16138136,16172226,16202468,16233172,16284116,16533239,16656155,16711199,16833144,16896909,16968574,17004032,17083641,17132098,17183084,17216798,17254805,17294301,17337931,17418230,17451982,17543747,17594167,17634329,17678363,17761816,17854574,17896338,17930669,17962476,18005668,18051331,18172922,18560560,18756414,18812675,18862735,18921435,18966180,19010838,19055850,19091821,19256345,19364885,19396629,19433528,19468323,19505643,19586519,19619867,19659796,19696326,19800213,19900179,19942348,19998403,20040810,20080896,20129595,20168833,20243036,20320745,20361390,20402499,20440184,20484796,20544825,20584327,20683703,20702166,20815409,20980046,21029171,21081954,21164912,21213721,21312291,21368513,21526234,21573456,21632074,21690785,21741000,21943464,22121428,22179023,22240106,22298579,22355692,22676951,22727922,22778115,22866693,22954196,22992149,23036048,23080584,23138152,23191937,23226779,23316619,23354938,23390443,23436331,23493301,23544030,23642655,23733088,23767736,23805047,23841424,23876111,23980710,24029376,24068414,24105449,24140293,24179839,24226606,24270171,24316408,24354508,24393212,24433191,24473426,24546603,24595676,24680435,24719797,24769659,24813582,24855353,24895361,24926314,24973752,25014740,25048798,25078414,25112883,25152015,25280255,25353155,25403822,25438606,25473865,25509605,25547454,25596150,25633443,25670374,25849960,25883474,25919981,26043084,26094256,26128873,26170711,26216616,26269754,26312895,26350077,26385718,26419178,26463436,26511941,26539214,26573825,26659618,26700301,26735717,26772423,26806392,26869177,26917735,26956118,26983950,27041757,27078072,27122208,27186636,27241591,27290054,27337595,27373918,27419179,27456803,27517671,27582360,2764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The position of the SNP locus on chromosome 17 comprises: 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respectively;

The positions of the SNP loci on chromosome 18 include: 59388,95919,111548,204814,252472,299724,405444,435833,472368,511009,549547,582734,617011,651551,680985,714378,751793,833872,865657,899866,937950,988628,1044792,1088272,1130939,1191418,1234174,1280026,1335265,1436914,1505233,1558812,1593106,1629693,1670445,1717543,1756469,1801797,1842908,1891260,1931066,1957529,1982946,2015601,2060317,2099267,2135466,2169279,2210583,2266798,2297986,2332770,2380157,2418085,2460759,2492386,2563154,2606057,2642951,2678279,2712180,2753411,2830672,2901148,2946448,2991515,3024264,3196356,3242575,3277162,3316176,3350073,3384176,3418464,3455984,3490471,3558116,3599424,3629633,3668061,3700771,3750980,3794396,3844986,3975494,4008599,4053614,4083561,4118444,4161572,4202622,4242887,4280712,4316301,4356352,4388537,4421552,4456681,4499657,4548823,4589283,4629348,4673164,4755369,4791068,4830863,4878847,4933592,4972834,5023457,5100124,5147490,5190861,5219865,5286076,5326955,5364916,5409721,5499830,5548672,5594739,5692313,5731251,5779890,5829705,5873630,5924607,5960068,5993859,6036979,6076906,6119790,6157072,6199459,6250983,6294047,6337489,6388977,6434158,6508305,6545875,6583968,6626549,6662252,6704756,6796110,6847940,6890411,6926854,6963828,6999368,7030450,7065323,7100828,7137816,7168468,7204218,7248346,7282531,7331085,7366739,7403687,7436953,7484216,7520914,7580972,7645003,7687679,7737499,7790899,7840035,7885531,7934969,7977410,8024438,8077858,8135572,8179937,8250662,8298871,8371843,8410768,8445152,8507785,8550999,8630286,8667407,8703302,8739460,8820886,8858422,8892362,8927124,8963003,8994831,9032642,9079763,9132371,9230668,9343873,9390655,9430895,9513023,9705201,9744160,9780938,9816271,9857364,9937814,9967164,10010426,10056339,10104747,10143384,10175158,10214581,10251981,10292881,10321853,10353707,10387068,10462636,10499643,10536793,10643952,10679128,10710530,10741946,10784331,10822428,10863771,10913492,10950506,11031166,11071687,11109550,11157240,11199425,11238106,11276769,11320782,11366783,11408342,11449223,11534183,11578528,11616251,11654176,11729029,11769148,11842887,11874548,11905953,11940799,11972116,12002551,12036610,12075431,12111262,12167953,12221985,12255300,12375871,12414499,12459410,12509095,12598459,12640183,12685321,12734851,12771159,12808140,12854340,12884676,12926924,12970275,13015490,13069796,13160516,13251234,13291698,13390244,13471295,13505686,13542861,13578887,13620294,13672407,13701979,13750551,13836334,13871684,13904668,13939569,13983973,14028993,14065037,14160616,14185530,14223336,14259310,14279150,14301153,14349528,14382275,14411607,14463075,14511944,14610280,14665681,14705908,14740746,14780777,14832424,14866373,14908714,14959300,15002003,15052618,15093211,15133057,15167944,15183336,15209106,15256718,15306073,15348421,15379714,15410313,18513345,18538610,18611243,18677089,18824417,18896030,18974408,19039266,19162853,19280800,19344612,19406847,19468635,19572159,19614316,19646740,19682131,19725197,19777745,19820907,19914189,19964645,20010871,20062034,20106717,20160581,20201911,20246323,20294153,20399435,20514272,20567883,20618082,20660330,20699029,20747183,20845537,20940689,20988701,21077207,21114997,21154943,21314315,21379516,21441302,21501766,21558866,21603805,21637216,21679098,21714182,21752172,21792711,21837165,21882812,21926121,21971165,22006244,22053605,22090217,22126080,22163139,22207589,22247642,22321177,22358076,22402449,22443352,22529054,22578908,22626170,22673354,22714608,22763335,22813136,22869369,22956049,23006011,23054210,23099810,23146123,23242346,23303664,23350992,23401898,23444096,23487306,23534044,23573098,23656489,23707994,23760319,23858237,23901737,23955260,24007502,24101749,24191021,24271378,24405040,24442580,24509663,24547138,24591355,24631358,24675748,24723763,24777533,24841163,24904188,24952522,25004159,25057791,25111040,25158553,25204161,25245308,25301535,25362977,25411535,25441209,25481035,25527707,25566317,25612276,25657876,25700435,25741877,25789269,25832357,25873349,25955510,26016830,26129728,26180690,26229642,26270166,26331734,26379410,26476437,26517205,26618583,26669253,26712899,26759910,26817903,26878802,26936161,26982652,27071828,27193345,27234003,27285624,27333762,27379173,27432956,27491494,27535666,27635308,27674072,27717461,27760901,27829579,27875024,27921679,27959676,27998727,28039282,28073338,28111388,28145428,28186594,28297988,28363713,28421734,28479781,28578506,28615354,28654178,28701462,28767024,28909329,28954225,29001571,29037814,29075164,29123759,29205953,29259129,29310401,29362630,29411722,29457886,29502263,29580120,29625535,29672676,29719151,29766033,29807287,29908792,29967006,30027092,30071388,30121169,30163086,30215033,30269631,30314632,30461178,30503160,30572822,30634652,30754960,30810112,30858466,30881667,30947576,31053378,31104359,31162123,31271619,31327318,31374412,31606097,31668079,31732388,31797312,31869974,31930577,31992108,32202495,32259398,32321794,32414465,32465952,32518790,32608804,32656935,32717380,32760753,32828547,32884268,32938869,32989846,33034175,33129076,33179357,33279657,33321683,33367953,33413127,33462063,33517945,33562227,33617415,33665075,33749371,33788441,33831682,33871081,33920558,33967277,34010589,34059157,34099913,34148356,34193419,34229194,34319157,34378445,34443765,34511406,34572968,34640709,34786089,34935496,34982881,35076342,35173468,35224987,35277848,35326624,35371106,35430332,35482042,35533277,35580083,35628804,35673039,35770485,35819409,35862642,35959232,35998453,36037061,36071951,36118149,36156774,36203841,36250517,36306999,36372225,36426522,36577642,36632661,36692045,36751860,36815582,36925486,36971454,37021457,37082773,37218846,37270472,37335340,37395546,37513230,37571008,37619957,37719317,37777080,37829879,37875781,37957018,37999500,38083812,38136815,38264488,38304682,38353385,38400722,38479732,38621118,38665265,38714499,38765007,38861555,38944999,38989153,39036005,39083827,39131943,39172387,39217734,39265215,39317914,39435052,39471367,39524695,39567322,39625623,39715794,39769815,39823559,39864712,39909507,39952103,39999601,40048135,40151027,40188988,40230147,40274813,40323522,40378436,40437051,40487283,40548565,40602733,40656927,40704169,40746119,40796381,40839329,40908195,41016256,41068078,41118154,41174573,41213971,41296289,41336477,41374612,41416260,41469412,41520932,41568657,41622878,41669617,41727571,41836988,41960274,42028517,42079377,42131942,42255446,42322434,42382532,42440241,42495289,42553406,42612253,42675317,42717857,42803197,42850619,42891844,42945958,42989453,43033082,43072895,43116108,43157248,43202071,43245172,43317899,43354922,43414078,43470463,43522359,43565380,43602266,43648327,43683462,43770384,43858614,43950787,43990769,44046644,44100786,44139122,44178402,44222319,44268448,44352267,44402624,44456958,44515756,44573040,44732687,44866074,44902499,44930359,44964353,45004946,45042148,45082572,45175402,45224608,45266831,45315765,45408465,45453442,45507884,45549383,45592887,45719568,45763646,45810709,45854264,45894890,45941303,45987176,46040789,46095661,46137084,46172186,46213735,46256897,46347806,46391160,46438049,46477521,46518005,46558991,46607563,46666465,46721655,46770186,46818234,46867972,46999755,47088690,47162687,47277903,47312993,47350712,47394484,47465240,47494244,47581748,47648230,47689240,47773812,47861441,47904366,47935056,47978186,48066920,48114256,48208629,48251054,48297672,48402338,48504993,48575389,48645922,48688407,48737039,48785113,48826156,48868170,48914921,48991965,49037316,49077690,49131088,49182219,49256742,49350277,49399322,49453027,49506313,49600611,49647642,49694715,49738276,49776578,49814133,49852379,49942082,49986288,50024503,50063072,50107542,50149178,50230968,50268426,50301737,50321735,50350354,50380636,50415880,50447700,50486644,50530232,50577714,50622457,50664398,50712188,50751464,50803750,50845265,50888006,50923261,50962303,51077313,51125096,51163450,51206454,51244405,51279462,51379795,51413565,51445835,51476420,51551701,51601628,51761523,51798196,51851415,51903607,51941821,51984511,52043127,52254552,52307930,52360903,52414186,52458819,52504027,52589645,52635782,52731414,52782449,52826754,52873317,52919151,52984980,53050646,53107295,53166994,53236441,53300235,53364338,53444123,53508765,53582840,53643430,53745257,53795300,53844726,53890684,53942194,54000943,54051566,54111483,54163188,54213670,54256771,54384751,54436577,54480918,54540833,54595738,54639769,54682714,54718651,54763914,54805560,54892553,54942829,54980364,55026323,55071242,55108340,55150271,55190395,55228396,55301189,55362816,55401130,55465683,55507311,55569942,55611412,55653015,55701407,55766474,55801616,55836472,55875268,55910523,55948271,55987072,56037488,56081444,56115566,56142789,56174075,56213431,56246361,56290754,56339727,56436118,56517062,56621911,56666721,56703742,56743365,56773039,56811418,56849707,56889787,56924093,56965390,57011192,57053442,57096276,57129771,57156576,57186586,57219970,57253742,57291999,57328243,57364900,57401423,57482403,57591651,57622218,57660487,57702877,57775587,57825167,57867955,57960229,58013834,58058844,58142147,58178586,58218003,58259105,58340602,58381591,58427463,58459626,58494527,58607873,58663768,58717021,58776925,58824083,58873843,58926268,58984541,59028063,59088521,59131138,59162574,59251980,59286443,59398268,59445110,59483763,59528677,59573817,59615699,59660996,59737370,59832985,59879919,59938052,59988779,60031599,60072816,60116804,60172958,60261910,60305878,60364693,60425214,60489518,60550417,60603484,60658999,60700381,60745359,60785955,60829901,60880324,60964227,61018788,61067716,61112849,61148323,61182941,61259917,61320300,61369545,61403689,61476025,61514968,61562608,61596107,61635819,61675757,61711727,61751058,61846689,61892130,61937099,61984223,62022104,62057730,62107377,62152269,62187516,62223620,62264706,62341087,62376721,62408556,62452031,62493061,62576119,62623904,62678191,62725477,62781548,62838895,62914955,62992133,63078059,63124847,63170422,63212381,63263763,63310511,63443264,63479822,63621381,63667275,63703619,63746922,63790026,63825103,63860120,63902240,63937888,63985614,64037136,64080077,64123099,64166723,64212650,64263640,64310630,64353624,64458574,64517795,64564246,64621496,64679837,64723260,64748095,64787463,64825765,64900536,64938754,64974571,65006574,65086614,65137673,65193272,65291253,65372423,65412083,65450112,65480447,65517676,65555663,65593373,65624116,65659420,65690353,65764732,65806627,65850253,65883165,65923775,65955669,66006306,66048794,66097726,66142159,66178460,66224777,66265127,66301902,66343048,66514712,66554209,66595454,66640864,66716945,66750950,66793283,66841564,66894766,67015865,67148463,67184251,67296198,67333410,67373076,67412894,67462526,67506204,67540522,67575482,67679255,67729609,67781001,67828096,67913091,67951054,67986588,68027361,68060147,68100624,68138405,68188093,68242682,68292721,68341050,68384491,68438100,68484491,68538385,68591002,68641447,68683153,68724678,68759288,68797188,68826750,68902504,68944790,68989001,69025497,69072475,69116252,69153071,69184208,69268128,69313846,69346106,69450827,69486258,69530906,69585984,69637256,69683902,69732019,69776618,69821739,69867349,69908145,70024078,70058086,70095903,70127144,70162162,70205438,70247019,70302983,70340916,70369184,70401410,70436479,70476621,70509824,70551122,70596106,70666828,70703104,70795151,70879810,70954254,71016910,71054389,71084562,71115861,71154515,71190600,71229942,71269818,71315998,71349599,71390420,71483765,71523024,71561968,71634801,71673195,71714751,71769917,71813194,71847348,71880089,71914831,71945545,72057879,72087217,72170359,72207561,72387595,72441535,72491902,72549405,72611796,72665248,72712233,72766524,72806398,72847210,72886907,72926779,72965896,73012076,73047672,73082414,73125475,73175791,73265469,73303972,73332578,73364465,73481285,73515233,73550726,73598902,73640632,73681011,73721975,73756623,73793176,73855294,73895049,73933801,73979799,74023921,74071514,74113179,74147024,74186642,74229495,74299559,74352127,74382277,74408805,74445142,74481554,74511644,74553361,74599977,74646087,74718957,74751183,74779179,74809870,74843381,74873461,74902311,74936212,74969338,75003154,75031313,75073357,75143045,75174910,75212973,75240377,75281202,75317737,75352927,75375990,75402671,75431402,75505427,75603905,75641491,75678426,75714705,75810132,75847172,75872964,75897618,76039907,76074987,76111881,76134675,76165293,76198058,76236433,76264903,76286186,76318974,76347258,76407696,76432155,76500990,76539421,76571902,76596404,76623622,76652528,76683825,76793550,76827908,76871974,76916902,76961218,77005865,77054354,77117292,77141592,77179374,77210072,77237142,77292331,77318678,77348108,77395780,77431709,77465207,77499980,77530420,77605355,77640867,77676044,77712065,77758837,77887159,77934588, respectively;

The position of the SNP locus on chromosome 19 comprises: 333217,365630,388817,418323,448173,472149,495722,526607,544649,567432,571087,571776,580349,593428,617379,643927,678695,710421,744122,780445,816263,841854,870566,895711,936264,969314,1002883,1030902,1056426,1087734,1158293,1188237,1234532,1285224,1323282,1365440,1404849,1451240,1526881,1609291,1641262,1679466,1714528,1756749,1790855,1836273,1961297,1997375,2030512,2071396,2112839,2190097,2238840,2275079,2321189,2379146,2408486,2440257,2514637,2567544,2596673,2631318,2664358,2703523,2739678,2773952,2815560,2851901,2888304,2944953,2980541,3012557,3048987,3118311,3143155,3170421,3196285,3233942,3278501,3311283,3344960,3424853,3460513,3504829,3548439,3589994,3627489,3672629,3719135,3802531,3838037,3971291,4018052,4053179,4102132,4220969,4255456,4293973,4429155,4475270,4511599,4545141,4586217,4623857,4667234,4717447,4749759,4781471,4818931,4856393,4892175,4958237,5002011,5044085,5078921,5132388,5183322,5214144,5254372,5333645,5370047,5400642,5438935,5477108,5509976,5588826,5653736,5753709,5789854,5830447,5857466,5890385,5937097,5993896,6036286,6083780,6125729,6159014,6197141,6233818,6273862,6309562,6345258,6380891,6416916,6456497,6496351,6534621,6572403,6606814,6663916,6694109,6721842,6765073,6797340,6833072,6868657,6908111,6934430,6965921,6992638,7055106,7099342,7130975,7216669,7273492,7403489,7436596,7472705,7525823,7561410,7607289,7681351,7750637,7771846,7806086,7871045,7919275,7971854,8022228,8120508,8151800,8188436,8219737,8250502,8291672,8325829,8386701,8420456,8466792,8509766,8554718,8595704,8635575,8682594,8769490,8803335,8847934,8922441,8999661,9039166,9078190,9107432,9160244,9193538,9227726,9257120,9337929,9385241,9437763,9532823,9568947,9615168,9707677,9763350,9809820,9853392,9975514,10016711,10063830,10131042,10172327,10221984,10319988,10367122,10488083,10587021,10635196,10675334,10724518,10770783,10929774,11001245,11069229,11115611,11216203,11244430,11279922,11323671,11410141,11454038,11512727,11559777,11611215,11659322,11703012,11748849,11794235,11843260,11925871,11969298,12024649,12075874,12123623,12229149,12283461,12339986,12393130,12443177,12493781,12530471,12558538,12612223,12654503,12714618,12761426,12811424,12871720,12932039,12993354,13051829,13098993,13155947,13227354,13287415,13328058,13368530,13416251,13446966,13482584,13524902,13565165,13613965,13654067,13696683,13735273,13779664,13836935,13877855,13911573,13951830,13999740,14052951,14102388,14153272,14207024,14264490,14322077,14372013,14416055,14454121,14497609,14550295,14590270,14629150,14674499,14716708,14763603,14805519,14851159,14912718,14956197,14992226,15030981,15066245,15101602,15128250,15160909,15195284,15274293,15395111,15465211,15525301,15588280,15632693,15676197,15704229,15737392,15767906,15785815,15803081,15876401,15948112,16003762,16030155,16062599,16113007,16172395,16210756,16260302,16300451,16342214,16413987,16508543,16616586,16679435,16733554,16787913,16830424,16866966,16906241,16964570,17008621,17049767,17093518,17128128,17213558,17293208,17332241,17451631,17601175,17643125,17686657,17730281,17769112,17801502,17842620,17880823,17917753,17949204,17989362,18030309,18080931,18125530,18160426,18188681,18227847,18273632,18317813,18363296,18395112,18441089,18579028,18631256,18715082,18763606,18811879,18853592,18906514,18956480,19015163,19105648,19157258,19202406,19247150,19288885,19343764,19395464,19449719,19506092,19562332,19617584,19676257,19733331,19790136,19839557,19880366,19925478,19987829,20040338,20082137,20115779,20156249,20183404,20225562,20258857,20303068,20390578,20438906,20476088,20578850,20623939,20661024,20695021,20731368,20756848,20787087,20841168,20882249,20914908,20952994,20979882,21013329,21042037,21074329,21114015,21138459,21167817,21214302,21255780,21295067,21384837,21453098,21529560,21562285,21609644,21647791,21684024,21710962,21743324,21757004,21791494,21813402,21829611,21853849,21895749,21938744,21978741,22025850,22075230,22110610,22150192,22199277,22237041,22274262,22363826,22441375,22477174,22508127,22541239,22623385,22708248,22739060,22777553,22809642,22840839,22870903,22905167,22940289,23022284,23057886,23089316,23136441,23229962,23411952,23450164,23477634,23493335,23541279,23582114,23620195,23682249,23744094,23771585,23812093,23841796,23905601,23966340,24044041,24119278,24153503,24184663,24266023,24325906,24371998,24401256,24433047,24468186,24493314,24518388,24538166,24557857,24576799,24595969,27733912,27736631,27739566,27749513,27760169,27793206,27805071,27815966,27830181,27849963,27859151,27870404,27880987,27894037,27910620,27928383,27946876,27965996,27999875,28034173,28065083,28103429,28141101,28186307,28232530,28278119,28304854,28314479,28328080,28348880,28408912,28533064,28552507,28604705,28643579,28679530,28724108,28766232,28829580,28863597,28895224,28927150,28964795,29007174,29087519,29119424,29167973,29289360,29315856,29379241,29488786,29516482,29551199,29590357,29633323,29717108,29811429,29838536,29867634,29895775,29928871,30002164,30037009,30072276,30105427,30149012,30188208,30223721,30336114,30407773,30449011,30497224,30593306,30630116,30674705,30770688,30821354,30876942,30971238,31014949,31067458,31109023,31153836,31257903,31299388,31387275,31436381,31493257,31551716,31604205,31650903,31699205,31751259,31803182,31858112,31898451,31991889,32035320,32128986,32166846,32221206,32264216,32364649,32425030,32477672,32519463,32568315,32691312,32739156,32786725,32836430,32891260,32994913,33034798,33104850,33135215,33167139,33212781,33252036,33300852,33345945,33380038,33453659,33492820,33530517,33620108,33661975,33704113,33740801,33772177,33818481,33862088,33903589,33981813,34032149,34072953,34116970,34156992,34196744,34240287,34280115,34323406,34355502,34400886,34449212,34497620,34538340,34624114,34676982,34730032,34778354,34827027,34880020,34910916,35009953,35050270,35087449,35130010,35175775,35220245,35261114,35317509,35363016,35413262,35495291,35536552,35610585,35654576,35684635,35723501,35765877,35810074,35921908,35960975,36000180,36039845,36085513,36142861,36233470,36281603,36369626,36408197,36452274,36504484,36557627,36600727,36640014,36677710,36757407,36835601,36886380,36929190,36976379,37023044,37128706,37188952,37246594,37299673,37351280,37401804,37444627,37476949,37568536,37658723,37712530,37794753,37848678,37902059,37962374,38024683,38071752,38123980,38172015,38225658,38283126,38348149,38445868,38485272,38527613,38572375,38755864,38801927,38849866,38900309,38941401,38979746,39018917,39059898,39108707,39163969,39209635,39247810,39334673,39420194,39463400,39494342,39554993,39592332,39627619,39669105,39708656,39787649,39846962,39945281,40032132,40111229,40130502,40220764,40254851,40291850,40337715,40369649,40423919,40465733,40507965,40565454,40617533,40662203,40703065,40760408,40876520,40924446,41011261,41153042,41197399,41289586,41331426,41362791,41440669,41481762,41516467,41546731,41587028,41697071,41842875,41880408,41923456,41962076,42010059,42060551,42110221,42154735,42201921,42240621,42284905,42331992,42374397,42422806,42486792,42566314,42650069,42724785,42797959,42922932,42981068,43047387,43106936,43233284,43273404,43324298,43360185,43395723,43430593,43505835,43544190,43579023,43608812,43647965,43685435,43711898,43752588,43786846,43826122,43873376,43919808,43957990,44005061,44042774,44118353,44163307,44219103,44266001,44301400,44339595,44379321,44474275,44509685,44558208,44608072,44650819,44713407,44773450,44862022,44890006,44914769,44961806,44991595,45055451,45096090,45138324,45178307,45329130,45442771,45518223,45568838,45661378,45702063,45746139,45798379,45868478,45950557,45988107,46164875,46208212,46309203,46350551,46396233,46434424,46525572,46568855,46616742,46674304,46718510,46792915,46829213,46878654,46915410,46943030,47004485,47079368,47126548,47173310,47221115,47267825,47305060,47341827,47504601,47544929,47589796,47647212,47702467,47760987,47846396,47932868,47985757,48088780,48131563,48212423,48279789,48320010,48342796,48372766,48489092,48518435,48577047,48603755,48634960,48665886,48702182,48733015,48769804,48800107,48840562,48881876,48926521,48976497,49060804,49121923,49170275,49211068,49328753,49361887,49436513,49469999,49510512,49546270,49589580,49672539,49745407,49772689,49825114,49869197,49901125,49944406,50013045,50052907,50101713,50141504,50199885,50244048,50294150,50343129,50384677,50457915,50486440,50515579,50639592,50690475,50727391,50762026,50802352,50854091,50889814,50916605,50955797,51075229,51110044,51151884,51237200,51268873,51303866,51329272,51353402,51408048,51466447,51498778,51528980,51556369,51598406,51640321,51687117,51732844,51776229,51818413,51857128,51886935,51919502,51964405,51997809,52030370,52135282,52166387,52200895,52234447,52275320,52316365,52388502,52434342,52473606,52515293,52563493,52609099,52690861,52725979,52766726,52807790,52850660,52885421,52919433,52975070,53001952,53027621,53054139,53089016,53149316,53215353,53242581,53278027,53309844,53336209,53399832,53434266,53466424,53499505,53535998,53574937,53640390,53684403,53724825,53827213,53860876,53892073,53922453,53942397,53970930,53994611,54051096,54091144,54120241,54152311,54183704,54235271,54290659,54321535,54356811,54394921,54426191,54462073,54503483,54527012,54558592,54595216,54627915,54692523,54741036,54772569,54801910,54838294,54930431,54964487,55001670,55095273,55123089,55183553,55240313,55258412,55278569,55294329,55325543,55343895,55392814,55428444,55451890,55513741,55539193,55562141,55588006,55625244,55663288,55694651,55784221,55832567,55906182,55944166,55989204,56076673,56115714,56167254,56214410,56250653,56280555,56313579,56342133,56370685,56432444,56461381,56494378,56538150,56567056,56595076,56618186,56686368,56716395,56746678,56770267,56813520,56851100,56932600,56986822,57032495,57077384,57121269,57226464,57256233,57304307,57359343,57403766,57436700,57470132,57502544,57570042,57641887,57675951,57714070,57753640,57792711,57833233,57864599,58004266,58038303,58194647,58247262,58293276,58339578,58381999,58434902,58481265,58523804,58559413,58597968,58629146,58664043,58705080,58747818,58953099,58996147,59035022,59074255, respectively;

The positions of the SNP loci on chromosome 20 include: 76231,126490,154635,194028,226253,278287,311216,344079,368876,402921,443296,485864,528866,564539,598071,632959,670103,735675,762778,793482,821909,885145,946498,986009,1025211,1117419,1163936,1198626,1286677,1332126,1367375,1478465,1518843,1567395,1625050,1659527,1689474,1757124,1805801,1848856,1884817,1921593,1959940,1994963,2034011,2117153,2188753,2221897,2259303,2296223,2394951,2431187,2473130,2552926,2584768,2617701,2645199,2682621,2722259,2765082,2846052,2989384,3065916,3108821,3187733,3224441,3265308,3303225,3377889,3419052,3516425,3556641,3697491,3771651,3802357,3840895,3911486,3994700,4057208,4079949,4110118,4142966,4214235,4332056,4410060,4446349,4486839,4525272,4562141,4594621,4630610,4672269,4703957,4731591,4763378,4791677,4823105,4855407,4899684,5009143,5145693,5187110,5226792,5262051,5290160,5360197,5404150,5435549,5465528,5505764,5539599,5581202,5617855,5647585,5680741,5711154,5742469,5770527,5798080,5830582,5923204,5959423,5993466,6061001,6093749,6128495,6167407,6244211,6319701,6355786,6397127,6430197,6465141,6513729,6558282,6592950,6636978,6670053,6704437,6781950,6816151,6853826,6890074,6929369,7037509,7073713,7117112,7161056,7199354,7238234,7270766,7311413,7350779,7388168,7428907,7458474,7497772,7543082,7586366,7619092,7652465,7688601,7726541,7770976,7856868,7901880,7940440,7983819,8022783,8070295,8112497,8158758,8232408,8269832,8360690,8446700,8489609,8564072,8610425,8648450,8689441,8731871,8765627,8800237,8827539,8860630,8902793,8945875,8992726,9032650,9070147,9118903,9167192,9279233,9322989,9366431,9405829,9495379,9532365,9577066,9622750,9664763,9709701,9749737,9791092,9834706,9876266,9954328,9997794,10031342,10075428,10105067,10146479,10188476,10282188,10323470,10362069,10400753,10436952,10478027,10523896,10583532,10634970,10680221,10727804,10771838,10822368,10865458,10911411,10952823,10986818,11026038,11067917,11188441,11231706,11427959,11473151,11520024,11566458,11607038,11651059,11733680,11845145,11888860,11935024,11975974,12017394,12165437,12205269,12247367,12284535,12336258,12424870,12458016,12498211,12533539,12578226,12613973,12647588,12711939,12745441,12790468,12830215,12871799,12913871,12947955,12984042,13017192,13047557,13080187,13120180,13165406,13210187,13279490,13319869,13362832,13407322,13451006,13501314,13551319,13596877,13694313,13735103,13779964,13825033,13907000,13999548,14051055,14100277,14158220,14257876,14355281,14399677,14449353,14498396,14536808,14630963,14679462,14721834,14802007,14887370,14926333,15008521,15052595,15085365,15124621,15163633,15250804,15295532,15333378,15374019,15411684,15449761,15562411,15598740,15637975,15664481,15738540,15766818,15802476,15877159,15914748,15952124,15987595,16025289,16057952,16095372,16135517,16173543,16202400,16231666,16285161,16332845,16379705,16455165,16493467,16529669,16562284,16600240,16633844,16665236,16701635,16740721,16776513,16853683,16887205,16933588,16970535,17010348,17049049,17133350,17171373,17219647,17263853,17310016,17335528,17371358,17414090,17445288,17478197,17515122,17555887,17594970,17630456,17668196,17739972,17768057,17802070,17836267,17864717,17898450,17934433,17967947,18005708,18040814,18079555,18119044,18162171,18198700,18237120,18276308,18325121,18406931,18447960,18487014,18528254,18563268,18606512,18687154,18765897,18801733,18847381,18889609,18929374,18974548,19012326,19053189,19099554,19141198,19196157,19236526,19277454,19353136,19393323,19427837,19460406,19541114,19582650,19669866,19704554,19781023,19811114,19849409,19879040,19907729,19940732,19974317,20082738,20161816,20201583,20248232,20283768,20329470,20407769,20462193,20531201,20587277,20645845,20757345,20802274,20835517,20881786,20964602,21006074,21048457,21139126,21185516,21237771,21292260,21346241,21403493,21458169,21515160,21560039,21607578,21700286,21754131,21801469,21842421,21889138,21936384,21988792,22037409,22082519,22127647,22172803,22272385,22340617,22382101,22424075,22469934,22507891,22541476,22581413,22629319,22669325,22703424,22741915,22775615,22808975,22836623,22872257,22918468,22962946,23000704,23041581,23079139,23150342,23198152,23241368,23276385,23315371,23354749,23390206,23432310,23461790,23499536,23534722,23607578,23642458,23681920,23716646,23745039,23777061,23805686,23838326,23877201,23917218,23952156,23976159,24006761,24041799,24077481,24117791,24154736,24188891,24218802,24261334,24291580,24405369,24432810,24517982,24563285,24610455,24650409,24681395,24721102,24751833,24820108,24858215,24895108,24928678,24958897,25000886,25046095,25089672,25157288,25195019,25235961,25270291,25307574,25354705,25397157,25435470,25474410,25569523,25662181,25738817,25758324,25836746,25847129,25865078,25878818,25889300,25899613,25909257,25923194,25937033,25952148,25985998,26074197,26087050,26103544,26129447,26140578,26147555,26189930,26205221,26214519,26244864,26254915,26261165,26270948,26277847,26293748,26302279,26310569,29421199,29428898,29437303,29448160,29456999,29469319,29481803,29493172,29510464,29530693,29548020,29560935,29573572,29583014,29588429,29593580,29598742,29605592,29612191,29618839,29624663,29630249,29636064,29645603,29649917,29805106,29814806,29827092,29861881,29959263,30089517,30135216,30177852,30320883,30372106,30423968,30475091,30571286,30659815,30705786,30799856,30845459,30892434,30944258,30992048,31042894,31089109,31147792,31196420,31236411,31278459,31310780,31346952,31379665,31458135,31497052,31541419,31584178,31620690,31656087,31695058,31734430,31775687,31813617,31921951,32011965,32120607,32174542,32283610,32335449,32380914,32438656,32479283,32515393,32607593,32716967,32777258,32835742,32878452,32931890,33087166,33147715,33203720,33302194,33361721,33477248,33524626,33568595,33611208,33647738,33728949,33825157,33869468,33919320,33971876,34012228,34102295,34146742,34180535,34228866,34280309,34411239,34500823,34559513,34610819,34718171,34767821,34832137,34883099,34996454,35047166,35100779,35155478,35204504,35244723,35291989,35347361,35445693,35497799,35589544,35628299,35680126,35731416,35780069,35820867,35859623,35900289,35987638,36054673,36099623,36190375,36224534,36250633,36288025,36324104,36371134,36516792,36559234,36599753,36656066,36757777,36792405,36826793,36874184,36953103,36984610,37012928,37057418,37162165,37212966,37249224,37280490,37318089,37359371,37396120,37432356,37488539,37534369,37584129,37684631,37723807,37771164,37879249,37926387,37974189,38101893,38148112,38191361,38235569,38272282,38305778,38354740,38398518,38454823,38495617,38545582,38598670,38644589,38686712,38820105,38862775,38905667,38954983,38989455,39033223,39079348,39122944,39168525,39214759,39263720,39300665,39343613,39379737,39414995,39456775,39540605,39583952,39669419,39723683,39784220,39886424,39935879,39986753,40134206,40188691,40246386,40297421,40342014,40388422,40430931,40515546,40558187,40599614,40678491,40717079,40754235,40795349,40924773,40968418,41003563,41042770,41077356,41111143,41145681,41185138,41227563,41264229,41309872,41342792,41384278,41424190,41503269,41683466,41724388,41762963,41804309,41846674,41892410,41937455,41983470,42022294,42091071,42130132,42175935,42213013,42287313,42321828,42359295,42536512,42616004,42652072,42724814,42759640,42797013,42835757,42869068,42908169,42951355,42987281,43025595,43062416,43115517,43168828,43224074,43268000,43305163,43342929,43379404,43431368,43480100,43518165,43561588,43605040,43689097,43733565,43774556,43823127,43902809,43931724,43959347,43991255,44028483,44096817,44137620,44211104,44245971,44290985,44338769,44423683,44458998,44495553,44527602,44566343,44642396,44729404,44801943,44843099,44892070,44936481,45023160,45109611,45191364,45223130,45307144,45354185,45385268,45487091,45525464,45559557,45595494,45629822,45661428,45695612,45731955,45796857,45863762,45905651,45948289,46071371,46113217,46145250,46222860,46265090,46298918,46337393,46369908,46397250,46429806,46468915,46496744,46524233,46634480,46672590,46715943,46757521,46792919,46830201,46857755,46890637,46929269,46966590,47004320,47063176,47094250,47130047,47145162,47177304,47211336,47246477,47281853,47320176,47402805,47448380,47494102,47524997,47570114,47625986,47673251,47711285,47749548,47792246,47908663,47951504,47994537,48079726,48125462,48164885,48204416,48272475,48349391,48382914,48412945,48489791,48530225,48563751,48598089,48634713,48674725,48712918,48752490,48868550,48909667,48952832,48992586,49032480,49067246,49101677,49137446,49229473,49299853,49339418,49379064,49409173,49489386,49530536,49575021,49613583,49655483,49695511,49736430,49776438,49807995,49852451,49887639,49927240,50000969,50027059,50135529,50173331,50208036,50246869,50273045,50305063,50338810,50398662,50433347,50497125,50529156,50569252,50604076,50641692,50676763,50711018,50740423,50779420,50820444,50868916,50913176,50958166,51001483,51036785,51077117,51134889,51179082,51231557,51266440,51303915,51372101,51415799,51460221,51554687,51711538,51748950,51787072,51822731,51862148,51906004,51946605,51984117,52027231,52107618,52142498,52206594,52247621,52315893,52385470,52419641,52451654,52478264,52491227,52526261,52560758,52598078,52630442,52730640,52793352,52822006,52895224,52926083,52960114,53004574,53041094,53078023,53156696,53195916,53262368,53289631,53316146,53347625,53390951,53431044,53461702,53495179,53528705,53562594,53597495,53629833,53665450,53690053,53714627,53756881,53788165,53822173,53859097,53893219,53928270,53973293,54013142,54091286,54124517,54151354,54187005,54217637,54270300,54301289,54334796,54368355,54397792,54432293,54503042,54540328,54574793,54626600,54671792,54716125,54824557,54855648,54887180,54967460,55008092,55092245,55130395,55166534,55206557,55241958,55276679,55307372,55345717,55380506,55417746,55451437,55478220,55511788,55542429,55579120,55609158,55640387,55669341,55734779,55767965,55802055,55843309,55893741,55934205,55974779,56008212,56042205,56074907,56113304,56146106,56180285,56285845,56326759,56365171,56404310,56433823,56466688,56497277,56527638,56633481,56708705,56745038,56772887,56815554,56858907,56898134,56980800,57021541,57101616,57139066,57172970,57206736,57290484,57330456,57368464,57412067,57456914,57493824,57539105,57572709,57616974,57705485,57793382,57877621,57917108,57957238,57984718,58018437,58057317,58090071,58133512,58164790,58206004,58283170,58320369,58353445,58389899,58435901,58484630,58538862,58582415,58662650,58688046,58723958,58760520,58797648,58835470,58935468,58979726,59024655,59061433,59102674,59197174,59238429,59297791,59329911,59360715,59399952,59437716,59471696,59507067,59545213,59582890,59616556,59645097,59676675,59708314,59749781,59783700,59818916,59884435,59912480,59942013,59968829,60003841,60032848,60076205,60110021,60140297,60167790,60205058,60234142,60293382,60318823,60352065,60376752,60412032,60443445,60501137,60522482,60554263,60585979,60689943,60728912,60758143,60789134,60832315,60869733,60957331,60984143,61018383,61051373,61087771,61168787,61190180,61342777,61371078,61403330,61437448,61465614,61496338,61534794,61573811,61607275,61669558,61706197,61734711,61765988,61847068,61880462,61919444,61981605,61998174,62028764,62063592,62095147,62127584,62190235,62216523,62241284,62275684,62308971,62343164,62402403,62437656,62470518,62593837,62633096,62680560,62723006,62756897,62770113,62833410,62872504,62908917, respectively;

The positions of the SNP loci on chromosome 21 include: 9416284,9572394,9651138,9677401,9832928,9849330,9863658,9893658,9970657,10012454,10086615,10381158,10423379,10476027,10550411,10612394,10702657,10707253,10712760,10716977,10722209,10727842,10735069,10744581,10750951,10763444,10774667,10785259,10797426,10810260,10841061,10858412,10886173,10900557,10930816,10965010,10999871,11029624,11039583,11046937,11055963,11061900,11066736,11072874,11078949,11085032,11092625,11100487,11109037,11127556,11133391,11139752,11155287,11186474,14342793,14350725,14359615,14368228,14390732,14412607,14473305,14561413,14636381,14683989,14735691,14752721,14778628,14844013,14946397,15062577,15229407,15247788,15266036,15288836,15314609,15336061,15359883,15403323,15438560,15457131,15483570,15530499,15607071,15631164,15655879,15692235,15719061,15791600,15865732,15936132,15964119,16002707,16041439,16097382,16133904,16162316,16195204,16242611,16292880,16345459,16383824,16427140,16498243,16535340,16580580,16780693,16814655,16895833,16935979,17016189,17053737,17160587,17219626,17272621,17332040,17372295,17411568,17467068,17522932,17599603,17670740,17746503,17779717,17821761,17860640,17905657,17995449,18063466,18110478,18154879,18196761,18231769,18266662,18301488,18335180,18375287,18407931,18479249,18560660,18626747,18669299,18794776,18826103,18857579,18896246,18931996,19005148,19050836,19082650,19126114,19267585,19339772,19422865,19499647,19564149,19612107,19645612,19816402,19864918,19904121,19942993,19977568,20024746,20065362,20105756,20139532,20179718,20212168,20241238,20284399,20317173,20354867,20426661,20462960,20508381,20549131,20591768,20638853,20682862,20721513,20773035,20823979,20904052,20969012,21006237,21050623,21088065,21128712,21176350,21211922,21243867,21286764,21368653,21447155,21527063,21575280,21618216,21663474,21695594,21839242,21893779,21966649,22122519,22151343,22193748,22233898,22351225,22382654,22417847,22481258,22510510,22557344,22596660,22635834,22710878,22751582,22793671,22864581,22940247,22981624,23022267,23061004,23227031,23274075,23308230,23347227,23380159,23424863,23480036,23538540,23638314,23751023,23829508,23874595,23925128,23952969,23996052,24029647,24066559,24102973,24150495,24220855,24261926,24313144,24363436,24405219,24444768,24481855,24565963,24600149,24640948,24679281,24718762,24760134,24797757,24828283,24865272,24905803,24935729,24971650,25003931,25049198,25093869,25187933,25218455,25251387,25284069,25322824,25358203,25389929,25414932,25439151,25460946,25485874,25513533,25546742,25579252,25627810,25712819,25753316,25803548,25846856,25889287,26017036,26054675,26095504,26169765,26210572,26257674,26305241,26349805,26392038,26446909,26504207,26552889,26591545,26684805,26799570,26847893,26904460,27029994,27118846,27155126,27182334,27212854,27249438,27317608,27348258,27377350,27405308,27489236,27533710,27573949,27622881,27661345,27697893,27742979,27786815,27834624,27935606,27979861,28015738,28124222,28169135,28210693,28248386,28293795,28341064,28382377,28449564,28490550,28558901,28591649,28629740,28669825,28710016,28745624,28786756,28819930,28864855,28905881,28959524,28999877,29121129,29168505,29209183,29248875,29297616,29335537,29382257,29426941,29457416,29487089,29514609,29554601,29592650,29702063,29738422,29768805,29801621,29834691,29917879,29953927,30031175,30076890,30109148,30137916,30178277,30219973,30251205,30338456,30384933,30433276,30628120,30686902,30737237,30785629,30835483,30865729,30967878,31004309,31045052,31091928,31135490,31177557,31218381,31248431,31290765,31330769,31418192,31509099,31545508,31589081,31621684,31662152,31703987,31744287,31790514,31833544,31883080,31979790,32037484,32075985,32104291,32150431,32196671,32235858,32378145,32421417,32449036,32490292,32568980,32603457,32650871,32698392,32737704,32771597,32806714,32843665,32919790,32962502,33000955,33043732,33094040,33143483,33181112,33224196,33255472,33329332,33360859,33427300,33464397,33499611,33542897,33580136,33631793,33676558,33719434,33766594,33804929,33838266,33880318,33971244,34022261,34141593,34187695,34245761,34338366,34377552,34422353,34575721,34644897,34672938,34708622,34829570,34872238,34930179,34988002,35048741,35105880,35163031,35221267,35295810,35340999,35376025,35414404,35538892,35580048,35625529,35674046,35720456,35754839,35786524,35826535,35862484,35929628,35966757,36011975,36050247,36133848,36188764,36234671,36279819,36323507,36447091,36525506,36566379,36638306,36678343,36886779,36959163,37001408,37031102,37071840,37116730,37177059,37290025,37357822,37442116,37479914,37514392,37548398,37624774,37662367,37768962,37816000,37848603,37920907,37956263,38003532,38040461,38081966,38126275,38170033,38214157,38254177,38345727,38561918,38602760,38651907,38688804,38725582,38773784,38862376,38910581,38958104,38996789,39035897,39064093,39102048,39145410,39238945,39285456,39383865,39434993,39539266,39589945,39634109,39673704,39717703,39807036,39844788,39897807,39937289,39974870,40014437,40060268,40152372,40190412,40225683,40260709,40298609,40337613,40401135,40432520,40499915,40544464,40580451,40619656,40657169,40690397,40723011,40764066,40809028,40855439,40893960,40924056,40955751,40988612,41062838,41096818,41127172,41155350,41190444,41256058,41287202,41323477,41351895,41383840,41424162,41497349,41532739,41565047,41596831,41637122,41671275,41717537,41838994,41904600,41935061,41994797,42018997,42068138,42105800,42141147,42180961,42215370,42253855,42288948,42324573,42373258,42474210,42508856,42548719,42637222,42678029,42721722,42761102,42802447,42831593,42941502,43028392,43069311,43101272,43132579,43161805,43225714,43255908,43288345,43327676,43399915,43443570,43470695,43498930,43532853,43597934,43637349,43679554,43715047,43752969,43782430,43848186,43884666,43931364,43972478,43995088,44026272,44061266,44095690,44136884,44173148,44206616,44249381,44279393,44385887,44415885,44453703,44479324,44514315,44566869,44601086,44764719,44798699,44830979,44868960,44919668,45123364,45163060,45196121,45229577,45260610,45298501,45342204,45387665,45430904,45482041,45572061,45608071,45635719,45669863,45734229,45772635,45812326,45839498,45869515,45916235,45952553,45989795,46013349,46045124,46075092,46106397,46138768,46171571,46205464,46244765,46268652,46330487,46362691,46393533,46412027,46441829,46475940,46523623,46566470,46614186,46657243,46686708,46764460,46795235,46827478,46904833,46928976,46958586,47165936,47213476,47252759,47291103,47318259,47344494,47374985,47430931,47485424,47510972,47544453,47561218,47613175,47651023,47687254,47713070,47746649,47785323,47817563,47842336,47878671,47917664,47955559,47997129,48033490, respectively;

The position of the SNP locus on chromosome 22 comprises: 16057288,16242751,16444659,16620586,16852685,16856595,16868364,16885814,16903325,16918399,16939393,16956851,17013924,17085746,17125738,17194240,17237414,17333650,17357915,17372703,17381841,17396176,17430558,17475942,17504077,17535049,17573272,17607174,17665135,17774161,17808961,17841198,17877906,17908596,17936616,18076467,18106823,18135129,18174781,18211329,18277438,18311300,18432033,18458035,18483013,18515631,18553028,18585820,18657355,18778156,18875965,18883566,18905328,18943415,18974986,19051371,19086904,19163047,19199403,19247209,19291766,19404733,19449571,19496423,19609106,19640667,19678313,19757010,19793593,19844234,19882630,19911619,19941947,19972935,20018969,20059344,20103462,20149985,20223508,20629154,20713559,20753223,20783721,20830422,20874540,20986448,21062296,21109206,21150840,21233783,21272897,21345091,21375994,21419163,21451951,21575930,21928597,22020483,22055589,22093837,22139208,22183980,22367697,22400049,22435054,22463754,22489560,22518338,22550401,22572034,22599953,22624656,22656699,22687958,22709354,22729306,22783396,22916243,22947837,22983489,23047893,23066978,23100385,23125650,23166939,23206697,23236406,23297693,23340805,23391131,23451356,23493873,23530961,23602419,23669372,23701581,23762264,23790919,23818837,23846492,23900837,23970897,24000068,24079724,24117959,24149768,24177636,24212056,24240089,24269519,24324016,24372494,24496099,24562398,24643540,24688968,24736280,24842098,24891166,24931625,24979004,25034777,25072287,25153606,25183877,25218912,25251671,25284552,25317044,25354656,25390270,25444874,25483767,25523876,25564047,25602790,25631756,25660119,25729594,25761936,25804453,25832687,25909119,25974887,26017001,26078646,26168894,26228942,26265357,26334249,26380596,26409140,26450986,26493132,26584585,26662382,26697195,26730293,26793073,26828619,26865058,26906216,26945788,26982424,27028313,27093674,27176574,27215701,27248223,27284036,27319646,27349278,27385279,27483480,27505558,27541354,27574903,27615461,27648408,27718759,27751796,27784836,27815619,27855798,27891917,27925722,27961612,27999372,28029538,28061578,28099616,28141113,28220424,28341053,28395422,28453818,28521553,28588692,28655314,28721065,28782960,28851868,28908195,28975913,29036303,29091443,29128013,29168360,29209728,29249525,29295898,29351034,29409445,29456360,29490668,29522251,29555480,29636985,29678569,29731755,29777146,29889650,29934120,29973634,30018643,30068570,30121500,30167931,30216900,30255462,30296059,30337335,30422468,30585746,30684787,30740157,30843355,30880262,30917825,30957832,31002638,31063617,31159625,31205912,31254555,31369636,31423708,31466685,31508195,31647724,31694861,31844293,31882278,32017509,32108997,32160708,32214274,32259855,32301770,32382309,32470485,32526658,32568831,32599540,32641683,32681058,32706509,32757417,32783210,32847759,32884942,32921697,32952699,32984761,33017539,33057006,33118615,33158093,33182004,33218431,33263931,33299596,33348284,33465413,33510161,33543050,33579610,33604051,33650660,33687940,33763746,33842875,33880290,33952694,33992541,34031333,34070819,34107919,34145831,34180801,34217687,34290257,34370403,34540680,34573465,34642027,34683829,34725083,34844073,34881535,34909133,34945097,34980085,35022040,35059183,35099134,35143901,35228878,35308678,35345623,35381546,35455664,35488540,35531612,35562148,35635864,35679787,35720198,35758742,35793266,35830470,35860563,35893900,35929749,35967818,36031861,36101450,36131158,36265616,36326172,36382858,36438869,36478989,36522134,36559476,36584260,36615706,36654145,36730947,36779064,36854851,36889485,36922997,36953965,36987577,37024359,37061519,37098913,37133413,37171795,37207484,37241090,37273205,37345923,37406778,37450840,37490714,37522525,37591373,37620663,37648151,37681968,37721217,37752697,37792590,37825180,37870939,37912754,37988349,38031491,38072876,38156518,38196474,38240841,38294830,38349525,38402956,38496556,38528391,38563541,38596646,38635486,38680816,38772004,38819028,38860740,38907849,38964460,39062007,39111812,39160569,39204683,39247333,39286923,39322400,39360018,39395101,39428958,39469000,39499072,39575931,39607698,39642338,39677317,39712936,39744254,39778327,39817348,39863980,39909121,39951454,40029845,40075834,40124460,40180308,40373570,40414607,40507074,40549566,40603363,40650617,40712637,40759034,40813063,40862885,40915813,40972769,41028308,41076141,41204323,41245806,41307588,41363730,41408697,41448195,41494994,41536320,41584928,41627073,41669738,41718696,41771306,41815305,41855949,41911621,41962626,42013434,42051167,42091013,42134786,42175283,42221951,42266168,42362560,42413978,42456140,42501630,42530096,42557991,42706035,42753014,42820191,42865011,42905119,42939245,42972441,43016259,43045458,43075948,43100238,43129179,43162286,43191404,43227257,43259338,43295560,43332917,43372780,43415273,43440400,43507163,43543462,43570068,43595931,43631079,43672183,43702268,43839229,43872598,43924876,44013348,44056176,44102016,44202556,44285069,44316789,44353447,44389400,44428015,44471389,44506233,44624734,44653289,44678726,44706814,44750693,44784753,44816777,44844243,44927476,44951812,44992632,45023250,45055584,45084259,45120084,45142177,45226519,45253953,45298174,45332310,45371568,45439659,45504764,45537472,45572370,45606511,45638165,45696672,45736087,45776576,45817438,45855171,45900865,45933740,46000105,46037048,46084192,46136298,46178991,46334281,46364150,46405845,46450616,46499702,46533658,46572063,46690141,46730215,46763822,46793783,46829197,46861091,46891122,46919495,46949538,46978509,47004179,47067547,47100250,47133580,47167510,47207475,47248289,47282589,47376559,47413929,47445095,47474013,47510793,47547265,47571342,47603829,47642162,47677211,47745086,47770651,47800611,47831067,47865923,47902521,47939486,47976253,48006248,48042907,48073595,48104604,48135383,48172174,48207318,48239482,48309921,48335187,48374222,48411777,48442453,48476049,48511936,48549166,48581558,48615590,48646439,48680069,48706642,48734161,48757226,48784485,48861523,48969991,49003154,49028413,49050237,49068935,49090646,49114275,49136285,49165390,49190094,49215182,49268705,49298491,49322938,49340692,49355550,49375523,49405431,49429681,49459958,49482299,49507434,49529438,49551620,49593552,49618978,49645065,49668630,49691071,49709694,49740616,49765146,49801544,49853908,49887600,49916560,49948433,49985751,50022958,50056891,50084219,50114083,50145334,50182704,50219119,50258016,50294378,50322324,50458283,50487316,50510849,50546418,50576193,50604854,50643085,50678701,50715029,50760505,50820836,50893806,50930802,50964018,50997145,51064169,51096831,51181563, respectively;

The positions of the SNP sites on the X chromosome include: 2247736,2723056,2726647,2772772,2818489,2853865,2925833,3050788,3106679,3156087,3221937,3264863,3379301,3461933,3528085,3581242,3628842,3741069,3919914,3974752,4035440,4112317,4175504,4241143,4426343,4596138,4659861,4797471,5024589,5076991,5243292,5336596,5408033,5660963,5778980,5920769,5996660,6075482,6234899,6314024,6407568,6770687,6850716,6944028,7038170,7139497,7489784,7599241,7858400,8172307,8271791,8357913,8498794,8583601,8878203,8991176,9098482,9218998,9292510,9374087,9421049,9495259,9589148,9679669,9753062,9836993,9913522,9982928,10088483,10173531,10269804,10365923,10520521,10656768,11050645,11229398,11364558,11497575,11604276,11709018,11825275,11935961,12218532,12313140,12488668,12570439,12631386,12730782,12802363,12885578,12949971,13022987,13114747,13234580,13618680,13815840,13970038,14079164,14185658,14325565,14444879,14581627,14663000,14864661,14978036,15069346,15193414,15360037,15436616,15529726,15621753,15727488,15819715,15923627,16038611,16170722,16249951,16555776,16700683,17105212,17223673,17366234,17508025,17777984,17917292,18072162,18199514,18339898,18493996,18671639,18763318,18852335,19100354,19300218,19542285,19770845,19894793,20045436,20175657,20312827,20428942,20558145,20680893,20788936,20997004,21132439,21277318,21458070,21665268,21809203,21917207,22005458,22087152,22179283,22259792,22394838,22537140,22618265,22700424,22779144,22910949,22992387,23073087,23163525,23230758,23298463,23387866,23472193,23560462,23645556,23908073,24004215,24086475,24179254,24340662,24566424,24647839,24754655,25014016,25135691,25193978,25303466,25581514,25693805,25778619,25859671,25941333,26152681,26239589,26355789,26462840,26584392,26714878,26823884,26922358,27000293,27075302,27161613,27256177,27449542,27600689,27676641,27767127,27882754,28001188,28321826,28450873,28533665,28658580,28769283,28850298,28949893,29075877,29167569,29268015,29398264,29796253,29904705,30145792,30250323,30347137,30448975,30538701,30635150,30801815,30923357,31008479,31092052,31242967,31323365,31481840,31574895,31687218,31774154,31854956,32026645,32096656,32257197,32322111,32395073,32468849,32539807,32662118,32739771,32888876,32962172,33028279,33089243,33160529,33254721,33355913,33448052,33555648,33648477,33762633,33863914,34061389,34160077,34265223,34382963,34462232,34651771,34744640,34825215,34988299,35065946,35314050,35526044,35620221,35822378,36141199,36369132,36473338,36600315,36687987,36788407,37039205,37212354,37416876,37530619,37737278,37827731,37913861,38021993,38133578,38262956,38333236,38399317,38509179,38625654,38748735,38861559,38973645,39105874,39231086,39354714,39681250,39780781,39888989,40001908,40101255,40203306,40285704,40374658,40457146,40657954,40768393,41035059,41127924,41284554,41361176,41481418,41643603,41795650,41916490,42133876,42289767,42565976,42670217,42784349,42880337,42979192,43136772,43408101,43636014,43765185,43877162,43982659,44226439,44321963,44481995,44789114,44905277,45034831,45245165,45508861,45601943,45957656,46088273,46193261,46285456,46400213,46528805,46642066,46791335,47174276,47498518,47625257,47730342,48014034,48149309,48457737,48566194,48732343,48875619,48980062,49071964,49161970,49496558,49630637,49758011,49897658,50451821,50671082,50783179,50910987,51178055,51303187,51434857,51618721,51745507,52569824,52680983,52891880,53097678,53218927,53356380,53513626,53910400,54095207,54426674,54541444,54771344,54893413,55122411,55238639,55341561,55476740,55652971,55731858,55850745,55912007,56007046,56093292,56184351,56482346,56599025,56680500,56780691,56949803,57077761,57274779,57369157,57475006,57557872,57812382,57923990,58064534,58139245,58258276,58359259,58419799,58460132,58487396,58516652,58546967,58562693,61686636,61727367,61731050,61734450,61756619,61774199,61800641,61817387,61837430,61853319,61872827,61886975,61915274,61960631,62085069,62197802,62411198,62954218,63137120,63271012,63355773,63435940,63579784,63700053,63767963,63975278,64091357,64219476,64362016,64438517,64671405,64815536,64948323,65087342,65308182,65416087,65521139,65601657,65676157,65761831,65862003,65986311,66127648,66255263,66351161,66457015,66566096,66681845,66855958,66983983,67079600,67177932,67408506,67653014,67787331,67894900,67993236,68090762,68189219,68315938,68408301,68509969,68596458,68697588,68832306,68959774,69175270,69287323,69395699,69508744,69640003,69865285,69990305,70100630,70178413,70362956,70438608,70691198,70846383,71129266,71369602,71472881,71562740,71739209,71897470,72274506,72397531,72499787,72715551,73098352,73231553,73359492,73487125,73582627,73699600,73840426,73983025,74154287,74288514,74400345,74530888,74621195,74729354,74834441,74940143,75063329,75106748,75172103,75324037,75410927,75489592,75591888,75730864,75882445,75943064,75996534,76070979,76115897,76171980,76257806,76267483,76412601,76515277,76831954,76976340,77158147,77343278,77482778,77614005,77725648,77798547,77931072,78153391,78256387,78374905,78478141,78574081,78629853,78720152,78805965,78905411,78970775,79052174,79097882,79143017,79219879,79348195,79445710,79561287,79715551,79792940,80043138,80343181,80480650,80785698,80899134,81042877,81138977,81251722,81358449,81479189,81644360,81745962,81832970,81939541,82131129,82236358,82329314,82435241,82573698,82716544,82866911,82999681,83138950,83270093,83377359,83509098,83627869,83713475,83789693,83867298,83971373,84222236,84332857,84424643,84542343,84660945,84823662,84883515,84955255,85018323,85125425,85215758,85324321,85392150,85548953,85619905,85738246,85820881,85912303,86097156,86174383,86253775,86330673,86393797,86499898,86569710,86632077,86707786,86793474,86874220,87047738,87118741,87285187,87383275,87468387,87531726,87572988,87622982,87681846,87740705,87796983,87891061,87984100,88174381,88264737,88346834,88419781,88514421,88721524,88786664,88847614,88897073,89028813,89102107,89181362,89247530,89335584,89400707,89463092,89518354,89578272,89637861,89688777,89760303,89820040,89879125,89937707,90003220,90069456,90133349,90209297,90273306,90335061,90484785,90580348,90687207,90828688,90956906,91187700,91324946,91363755,91527762,91575474,91625647,91758818,91818708,91947974,92007907,92083330,92133157,92200854,92252891,92304557,92353261,92413353,92685644,92752089,92825885,93060122,93167552,93264076,93346427,93423002,93596095,93780313,93897106,94014903,94097292,94189382,94282356,94375081,94455637,94655782,94777039,94892333,94993102,95092667,95239914,95319527,95540353,95607330,95718391,95815227,95903084,96014318,96090793,96203190,96339699,96434755,96529410,96647727,96784023,96892106,97209636,97306908,97409778,97531050,97777683,97880585,97993450,98112677,98244967,98489683,98634884,98768317,98883862,99030999,99132620,99228188,99333238,99561814,99764645,99882543,99971352,100071301,100347118,100435355,100534438,100609438,100673586,100791617,100897984,101018561,101217305,101303220,101399025,101923418,102047079,102167613,102297849,102395978,102493441,102609488,102739586,102868950,102979095,103047606,103137615,103531511,103687472,103838055,103978079,104127507,104252681,104565350,104685898,104830130,104946614,105225843,105344924,105490973,105661527,105958939,106256388,106362430,106480937,106620310,106780618,106910255,107026805,107162475,107284339,107425309,107545662,107763538,107845115,107929301,108037290,108111049,108293470,108399575,108491687,108616957,108744008,108858688,109005318,109095000,109201721,109329902,109508834,109710502,109816218,109912294,110003600,110138513,110285720,110422204,110559643,110697306,110851322,111012035,111242944,111356910,111462376,111534036,111636471,111734920,111932083,112067381,112256579,112366947,112452147,112553469,112657423,112770310,112864203,112941009,113059660,113147877,113261156,113349619,113481339,113624829,113741944,113861510,113968909,114061198,114244548,114605041,114709751,114789361,114891664,115014610,115100792,115223760,115311011,115397111,115481604,115775851,115863438,115940364,116001898,116095179,116168464,116231302,116457865,116528251,116587390,116651039,116754839,116820686,116905279,117105512,117216102,117368703,117449641,117526021,117688822,117809414,117969872,118041750,118121382,118206620,118495542,118617649,118681825,118756484,118840392,118892474,118954012,119029054,119104380,119406962,119591135,119818275,120005338,120344340,120580478,120693514,120940070,121030445,121128552,121219659,121312708,121475780,121556308,121819527,121896909,121980159,122163503,122265252,122360725,122473332,122584172,122696559,122812180,122868557,122919621,122996252,123273413,123421001,123518852,123711355,123823890,124003799,124124103,124222516,124306181,124405240,124495416,124585335,124661034,124736106,124824611,124940100,125055100,125146744,125238194,125435231,125507565,125606370,125680230,126072482,126182527,126371135,126455182,126564476,126665727,126748679,126809636,126909753,127169217,127276021,127376997,127494763,127638011,127873425,127959242,128052297,128134757,128246124,128347294,128425453,128518182,128636472,128743228,128903472,129560425,129644583,129751234,130123120,130255991,130380462,130492122,130604660,130716953,130847166,131026517,131131827,131388718,131542498,131719473,132092023,132219575,132367014,132610554,133001689,133165103,133492339,133596418,133662605,133772306,133919538,134166632,134669316,134786450,134975438,135096039,135199177,135305804,135458848,135565593,135805503,135918726,136012789,136130499,136246693,136359020,136446829,136747199,136851415,136967494,137180011,137293810,137384309,137484331,137577916,137690086,137832884,138151701,138255170,138330926,138424492,138600830,138669578,138759178,139086172,139155386,139330678,139636645,139721973,139894872,139977743,140050689,140269630,140358350,140442074,140506439,140697174,140780527,140930467,141086936,141154190,141216789,141287277,141362523,141447156,141614525,141679795,141740128,141811816,141899797,141975671,142159350,142265721,142347861,142445351,142562505,142632686,142708882,142789028,142867071,142958662,143051956,143153877,143340207,143407745,143735678,143819163,143917456,144009483,144087996,144166886,144246695,144298395,144452817,144556105,144646529,144732712,144833007,144993077,145077839,145163584,145341136,145422489,145505768,145584154,145649530,145738385,145978838,146060061,146142150,146246173,146346011,146453158,146633426,146712451,146923549,147434007,147547796,147662555,148007563,148258888,148369123,148485130,148573408,148699077,148887258,149135222,149275091,149399646,149513612,149618774,149702027,149936269,150048256,150126802,150274333,150349871,150425915,150506484,150683157,150779555,150849025,150926313,151087610,151166990,151261356,151330581,151424101,151533532,151648050,151907964,152044451,152144399,152210481,152485061,152602717,152860457,152933009,153008083,153238494,153358913,153630255,153708719,153780401,153968860,154081055,154183650,154311568,154456711,154625420,154785397,154898561.

3. A method of assessing genomic abnormalities, comprising:

selecting a plurality of SNP sites according to claim 1 or 2, and constructing a capture probe or a kit capable of capturing nucleotide fragments containing the SNP sites;

extracting DNA of a detection sample;

constructing a detection sample DNA library;

hybridizing the capture probe or the capture probe in the kit with the DNA library for capture, and sequencing;

performing bioinformatics analysis on the sequencing result to obtain the sequencing fragment ratio corresponding to each heterozygous SNP site;

calculating a genome anomaly index based on the ratio of sequencing fragments corresponding to the heterozygous SNP locus;

4. The method for assessing genomic abnormalities as set forth in claim 3, wherein said obtaining the ratio of sequencing fragments corresponding to each heterozygous SNP site comprises:

the ratio of each allele was calculated using the number of each allele and the total number of all alleles.

5. The method of assessing genomic abnormalities as set forth in claim 3, wherein said genomic abnormality index includes: LOH, TAI and LST, wherein LOH is the copy number of a secondary allele in a segment is 0, the copy number of a primary allele is not 0, and the length of the segment is more than 15M; TAI is initiated from telomere and does not cross the centromere, the fragment length is greater than 11M; the LST is a case where after deleting segments shorter than 3M, the lengths of two adjacent segments are both greater than 10M.

6. The method for assessing genomic abnormalities according to claim 5, wherein said calculating a genomic abnormality index based on the ratio of sequenced fragments corresponding to heterozygous SNP sites comprises:

detecting heterozygous SNP sites located on the same chromosome arm, and classifying the adjacent heterozygous SNP sites into the same segment if the rank and the detection P value of the adjacent heterozygous SNP sites are greater than the threshold value, so as to realize the segmentation of the genome;

7. A capture probe for assessing genomic abnormalities, wherein said probe is used for capturing a nucleotide fragment comprising a plurality of SNP sites according to claim 1 or 2.

8. A kit for assessing genomic abnormalities, which comprises at least one dose of the probe of claim 7.

9. Use of the probe of claim 7 or the kit of claim 8 for assessing genomic abnormalities.

10. Use of the probe of claim 7 or the kit of claim 8 in the manufacture of a product for assessing genomic abnormalities.