CN114983001A - Additive for tobacco products, preparation method and application thereof - Google Patents
Additive for tobacco products, preparation method and application thereof Download PDFInfo
- Publication number
- CN114983001A CN114983001A CN202110230583.7A CN202110230583A CN114983001A CN 114983001 A CN114983001 A CN 114983001A CN 202110230583 A CN202110230583 A CN 202110230583A CN 114983001 A CN114983001 A CN 114983001A
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- Prior art keywords
- acid
- additive
- organic acid
- nicotine
- tobacco product
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Classifications
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/26—Use of organic solvents for extraction
Abstract
The invention relates to an additive of tobacco products and application, wherein the additive comprises an organic acid and a solvent, and the organic acid can provide H + Protonic acid selected from two or more of monobasic organic acid, dibasic organic acid and tribasic organic acid, and the additive is used in the amount of H + The acid-base neutralization reaction of the protons with the N neutralizes at least 30% of the total nicotine nitrogen content of the tobacco product. The nicotine alkali in the tobacco product is neutralized, so that the nicotine addiction eliminating efficiency and the taste balance in the smoke are improved under the condition that the nicotine concentration of the product is reduced.
Description
Technical Field
The invention relates to the technical field of additives used for tobacco products, in particular to an additive for liquid atomized electronic tobacco tar and a tobacco product which is not combusted by heating.
Background
New tobacco products typically include two broad categories of liquid-atomized e-cigarettes and heated non-combustible (HnB) products.
The liquid atomization electronic cigarette uses nicotine salt electronic cigarette oil as the cigarette oil formula, the most common nicotine benzoate formula is sold in the market, wherein the molar ratio of nicotine to benzoic acid is 1:1, the use of the ratio is from the balancing of a pure acid-base reaction, and the common use concentration of the nicotine salt in the cigarette oil is 9 mg/mL-59 mg/mL. In the concentration interval of 9mg/mL-20mg/mL meeting the European Union standard, the use feeling (addiction relieving degree and throat hitting feeling) of tobacco tar can not meet the requirements of mature smokers, so that a plurality of smokers can alternately use cigarettes and electronic cigarette products at the same time in regions within the European Union, and the smokers in regions outside the European Union prefer the electronic cigarette products with the concentration of more than 30 mg/mL.
Since the concentration of the ingested nicotine is directly related to the peak of nicotine concentration in human blood, and scientific literature also considers that the peak of nicotine blood concentration is also directly related to addiction, electronic cigarette products containing more than 30mg/mL of nicotine are often taken as a potential more addictive product than cigarettes, and are used as reasons for preventing the development of new tobacco industry by people who object to electronic cigarettes as cigarette substitute products.
The tobacco core is not burnt when being heated, namely, the pretreated natural tobacco is pressed into a sheet or the tobacco core which is put into a matched smoking set and heated to more than 300 ℃ to generate smoke which is inhaled by smokers. The product evaporates the nicotine existing in the solid cigarette core into the smoke by heating the cigarette core, and the efficiency of transmitting the nicotine in the solid cigarette core into the smoke by a heating mode is low, so that the nicotine is not enough to provide the smokers with the required addiction-relieving feeling. Although the toxic and harmful byproducts generated in the combustion of the traditional cigarette are reduced, the working temperature of the cigarette is generally higher than 300 ℃ and reaches 350 ℃, and a small amount of toxic and harmful byproducts such as nitrosamine, formaldehyde and the like can be generated in the high-temperature tobacco products above 300 ℃.
Meanwhile, a great difference between the existing heating-free and cigarette experience lies in that the first-mouth smoking addiction-relieving experience is lack of the first-mouth smoking addiction-relieving experience, and the first-mouth smoking addiction-relieving experience needs to climb slowly to achieve the addiction-relieving effect. For the mature smokers, the motivation for replacing cigarettes as addiction-relieving products is low.
In addition, the invention patent of patent publication No. CN111671131A discloses a composition comprising 0.5-1.5 parts by weight of water extract of flue-cured tobacco, 1-5 parts by weight of ethanol extract of flue-cured tobacco, 3-7 parts by weight of Maillard reactant of flue-cured tobacco, 0.01-0.5 part by weight of molecular distillation light component of flue-cured tobacco, 0.5-2 parts by weight of organic acid and 1-2.5 parts by weight of nicotine. The composition can be applied to the electronic cigarette atomized liquid to realize mellow and outstanding tobacco fragrance and vivid characteristic style reduction. This document emphasizes the reduction of tobacco aroma by the addition of various combinations of flue-cured tobacco extracts with the use of organic acids. However, this document only provides a broad acid-base weight ratio and fails to establish a truly effective acid-base neutralization range for different organic acids and nicotine due to differences in steric structure. In addition, if the weight ratio of part of organic acids in the literature is not subdivided for specific acids, the neutralization reaction ratio of the organic acids and nicotine is completely different, and the nicotine alkalinity in the smoke can not be completely and effectively neutralized, so that the effects of sufficient addiction elimination and acceptable throat-hitting feeling can be provided.
Along with the gradual improvement of a novel tobacco product management system and the great trend of low nicotine content and flavor removal and refinement of international novel tobacco. Aiming at the liquid atomization electronic cigarette, the problem that the addiction relieving degree and the throat hitting feeling of the mature smokers are satisfied is provided on the premise that the nicotine concentration in the tobacco oil is further reduced, or the problem that the addiction relieving degree of the product to the smokers is improved by heating the non-combustible dry flue-cured tobacco is needed to be further considered by technical personnel in the field.
Disclosure of Invention
The invention aims to provide an additive which can be used as an additive for liquid atomization of electronic tobacco tar and heating of a non-combustible dry flue-cured tobacco product, can provide satisfactory addiction-relieving degree and throat-hitting feeling for mature smokers even under the condition of reducing the nicotine concentration in the electronic tobacco tar, and can remarkably improve the addiction-relieving degree of the smokers when being used for heating of the non-combustible dry flue-cured tobacco product.
The invention can also be used as an additive applied to the traditional cigarette to play a role in softening smoke and improving aroma and play a role in improving smoke addiction eliminating experience for low-nicotine cigarette products.
The invention mainly aims at the different molecular structures of organic acids and the molar ratio of nicotine through the composition of the organic acids of specific types and nicotine, and can achieve the effect of relieving addiction which is not inferior to a high-concentration nicotine product even under the condition of reducing the total content of nicotine in the product, thereby reducing the possibility of addiction deepening of smokers from the aspect of long-term use.
The technical scheme adopted by the invention for solving the problems is as follows: an additive for tobacco products comprises an organic acid and a solvent, wherein the organic acid is capable of providing H + Protic acid of a proton selected fromTwo or more of organic acids, dibasic organic acids and tribasic organic acids, and the additive is used for neutralizing at least 30% of the total nitrogen content of nicotine in the tobacco product.
Preferably, the organic acid is selected from two or more of saturated carbon chain carboxylic acid, unsaturated carbon chain carboxylic acid, alpha-hydroxy acid, keto acid, and aromatic acid.
Preferably, the organic acid is selected from two or more of lactic acid (monoacid), tartaric acid (diacid), citric acid (triacid), levulinic acid, malic acid (diacid), pyruvic acid, salicylic acid (monoacid), acetic acid (monoacid), propionic acid (monoacid), butyric acid.
Preferably, the total content of the monobasic organic acid is 50 to 99 wt% in the total amount of the organic acid; or the total content of the dibasic organic acid is 10-99 wt%; or the total content of the ternary organic acid is 10-99 wt%.
Preferably, the solvent is one or more of 1, 2-propylene glycol, 1, 3-propylene glycol, glycerol, water and ethanol. Preferred are polyhydric alcohol-containing solvents such as propylene glycol, glycerin, and propylene glycol and glycerin.
The additive also comprises a cosolvent. The cosolvent can be water, and the addition amount of the water as the cosolvent in the additive is not higher than 5 wt%; or the cosolvent is selected from one or more of ethanol, propanol, butanol, pentanol, ethyl acetate and ethyl lactate, and the addition amount of the cosolvent in the additive is not higher than 1 wt%. The cosolvent is used for promoting the dissolution of the organic acid in the solvent, especially when the organic acid is a mixture
The preparation method of the additive of the tobacco product comprises the following steps: adding organic acid into a solvent in sequence, adding a cosolvent according to needs, stirring until the cosolvent is completely dissolved to obtain the additive, and storing the additive at normal temperature in a sealed manner.
The invention also provides an application of the additive: the additive is added into tobacco product according to H in the additive + The molar ratio of the protons to the nicotine in the tobacco product is set to be 0.6: 1-3: 1.
Compared with the prior art, the inventionHas the advantages that: the application focuses on precisely designing and determining the molar ratio of the acid to the nicotine according to the structures of different types of organic acids and the space reaction efficiency of the organic acids and the nicotine when the organic acids in the additive are used for neutralizing the alkalinity of the nicotine in smoke; meanwhile, on the basis, the use of total acid and nicotine is reduced by the combination of more than two acids, the addiction-relieving effect of the product can be still improved, and the flavor-enhancing effect is achieved. The nicotine molecule contains two nitrogen atoms (the nitrogen atom on the five-membered ring is strongly basic, and the nitrogen atom on the six-membered ring is weakly basic). Theoretically, each mole of nitrogen atom can be associated with one mole of protons H + Forming covalent bond. However, because the space structure formed by two rings in nicotine molecule is adapted to the space required by the three-dimensional structure and size of the molecule of different organic acids when they coexist with different organic acids to form N-H covalent bond, the molar ratio of each acid (monoacid, diacid, triacid) to completely neutralize nicotine alkalinity is different, for example, each triacid can provide three moles of protons H + Formed but limited by the steric structure of the triacid, these three moles of protons H + It may not be possible to use all for neutralizing the N-H bond of nicotine. In order to achieve complete neutralization of nicotine alkalinity (acid-base reaction), the dosage of the monobasic non-aromatic acid in the formulation of the present application should be 2:1 to 3:1 molar ratio with nicotine, the dosage of the dibasic non-aromatic acid should be 2:1 molar ratio with nicotine, the dosage of the tribasic non-aromatic acid should be 2:1 molar ratio with nicotine, and the dosage of the aromatic acid should be 1:1 molar ratio with nicotine because of the cyclic structure. The application uses a combination of more than two acids, so the optimal molar ratio of a single acid to nicotine in the combination is designed and calculated firstly, and then the balance required by addiction relief and mouthfeel is achieved through subjective tests by adjusting the ratio of a plurality of acids in the combination. Because the present formulations are more preferably mixtures of organic acids, the range of total amounts of acid formulations used is relatively large. Tested, aiming at the proton H of organic acid selected from monoacid, diacid and triacid + The molar ratio of the nicotine to nicotine is (0.6-3): preferably 1. This not only ensures sufficient neutralization of nicotine alkalinity,moreover, based on the difference of the neutralization reaction principle of different acids and nicotine, the neutralization reaction process of the additive to the nicotine can be controlled, and the balance required by addiction relief and taste is sequentially obtained, and at least 30 percent of the total nitrogen content of the nicotine in the tobacco products needs to be neutralized for the application to achieve the expected effect.
In addition, alcohol solvents such as propylene glycol and glycerol are preferably selected in the application, and the common atomized smoke solvent is used as a solvent for preparing the tobacco tar, and is heated and evaporated by a smoking set and absorbed by a user through a mouth moistening environment to form aerosol particles due to the high water absorption of hydroxyl groups, so that partial throat hitting experience is provided, and after the aerosol is exhaled by the user, the aerosol is formed in the air, so that the visual effect of simulating the smoke of the cigarette is achieved, and the experience satisfaction of smokers in the smoking process is improved in a sensory mode.
The additive is used as an additive for producing tobacco shreds and tobacco powder slices, and can neutralize free nicotine alkali in the smoke to the maximum degree under the condition that the tobacco cores are heated or combusted, so that the taste of the smoke is greatly improved. In addition, the liquid can permeate into solid nicotine carriers such as tobacco powder, tobacco shreds and the like, the nicotine in the solid can be volatilized in the heating and evaporating process, the conversion rate of the raw material nicotine is improved while the nicotine content of the product is improved without additionally backfilling, the addiction-removing efficiency of the nicotine in the smoke is improved, and therefore the working temperature of heating and non-burning the product can be properly reduced to reduce the generation of toxic and harmful byproducts such as aldehydes and the like.
Detailed Description
The present invention is described in further detail below with reference to specific examples, which are intended to be illustrative and not to be construed as limiting the invention.
The first embodiment is as follows: the additive formula contains lactic acid, tartaric acid and citric acid in a molar ratio of 7.5:1:1.5, the three acids are sequentially added into propylene glycol to form a mixed acid-propylene glycol mixture with the organic acid concentration of 30 wt%, the mixture is stirred at normal temperature for more than 20 minutes at the stirring speed of more than 50rpm until the mixture is completely dissolved, and water with the weight percent of less than 5% is added in the period to help the solid acid to be completely dissolved. Before being used as an additive of a novel tobacco product, the solution is kept standing at normal temperature and in dark place.
Example two: the additive formula contains lactic acid and tartaric acid with a molar ratio of 3:1, the two acids are sequentially added into propylene glycol to reach 30 wt% of mixed acid-propylene glycol mixture, the mixture is stirred for more than 20 minutes at normal temperature and the stirring speed is more than 50rpm until the mixture is completely dissolved, and less than 5% of water can be added to assist the solid acid to be completely dissolved. Before being used as an additive of a novel tobacco product, the solution is kept standing at normal temperature and in dark place.
Example three: the formula of the additive contains levulinic acid and lactic acid with the molar ratio of 2.7:1, the two acids are sequentially added into ethanol and propylene glycol to form a mixed acid-ethanol-propylene glycol mixture with the weight percent of 50 percent, and the mixture is stirred for more than 20 minutes at normal temperature and at the stirring speed of more than 50rpm until the mixture is completely dissolved. Before being used as an additive of a novel tobacco product, the solution is kept standing at normal temperature and in dark place.
Example four: the additive formula contains lactic acid and tartaric acid with a molar ratio of 3.6:1, the two acids are sequentially added into glycerol and propylene glycol to reach 50 wt% of mixed acid-glycerol-propylene glycol mixture, and the mixture is stirred for more than 20 minutes at normal temperature and at a stirring speed of more than 50rpm until the two acids are completely dissolved. Before being used as an additive of a novel tobacco product, the solution is kept standing at normal temperature and in dark place.
Example five: the additive formula contains lactic acid and malic acid with a molar ratio of 2:1, the two acids are sequentially added into propylene glycol to form a mixed acid-propylene glycol mixture with a weight percentage of 50%, and the mixture is stirred for more than 20 minutes (the stirring speed is more than 50 rpm) at normal temperature until the two acids are completely dissolved. Before being used as an additive of a novel tobacco product, the solution is kept standing at normal temperature and in dark place.
Example six: the additive formula contains pyruvic acid and lactic acid with the molar ratio of 2.5:1, the two acids are sequentially added into propylene glycol to form a mixed acid-propylene glycol mixture with the weight percent of 50 percent, and the mixture is stirred for more than 20 minutes at normal temperature and at the stirring speed of more than 50rpm until the two acids are completely dissolved. Before being used as an additive of a novel tobacco product, the solution is kept standing at normal temperature and in dark place.
Example seven: the additive formula contains lactic acid and salicylic acid with a molar ratio of 5:1, the two acids are sequentially added into propylene glycol to form a mixed acid-propylene glycol mixture with a weight percent of 50%, and the mixture is stirred for more than 20 minutes at normal temperature and at a stirring speed of more than 50rpm until the two acids are completely dissolved. Before being used as an additive of a novel tobacco product, the solution is kept standing at normal temperature and in dark place.
In all of the above examples, small amounts (< 1%) including, but not limited to, ethanol, propanol, butanol, pentanol, ethyl acetate, ethyl lactate, etc., are used as necessary to aid dissolution.
The additive and the nicotine stock solution in the first, second and third embodiments are respectively used as raw materials in mass ratios of 2:1, 3:2 and 1:1 to prepare 20mg/mL liquid atomized smoke samples, and more than ten smokers perform blind tests on 36mg/mL nicotine salt retail products of the original favorite foggy product and 36mg/mL nicotine salt retail products of the competitive products (purchased in the market), and the results show that the formula is obviously superior to other products in relieving addiction and hitting throat and provides trace fruity faint scent similar to natural plants under the condition that other spices are not added.
The liquid atomized smoke sample of 20mg/mL is prepared by using the additive of the first embodiment as a raw material and nicotine stock solution in mass ratios of 2:1, 1.8:1 and 1.6:1, more than ten smokers are blindly tested with a retail product of nicotine salt of 36mg/mL and a retail product of nicotine salt of 36mg/mL (purchased in the market) which is a favorite original, and the result shows that the formula of the first embodiment is obviously superior to other products in addiction relieving and throat hitting, the throat hitting feeling is improved along with the reduction of the addition ratio of the additive, and the addiction relieving degree is not obviously changed. Wherein, the sample prepared by 2:1 of the additive and the nicotine actually reacts with the nicotine in the optimized molar ratio of each acid in the formula, namely completely reacts, is optimal in three proportions in the aspect of addiction elimination, but the throat-hitting feelings of 1.8:1 and 1.6:1 are more obvious for the stronger throat-hitting feelings favored by part of old smokers. Therefore, the addiction-relieving degree and the throat-attacking feeling are two smoker experiences needing to be balanced.
The third example is used as an additive and a nicotine stock solution, the mass ratio of the additive to the nicotine stock solution is 1:1, 0.95:1, 0.9:1 and 0.85:1, 20mg/mL liquid atomized smoke samples are prepared, more than ten smokers are blindly tested with 36mg/mL nicotine salt retail products of an addiction-to-foggy source and 36mg/mL nicotine salt retail products of a competitive race (purchased in the market), and the results show that the formula is obviously superior to other products in addiction-relieving and throat-hitting effect, the throat-hitting effect is improved along with the reduction of the additive addition ratio, and the addiction-relieving degree is not obviously changed. Wherein, a sample prepared by 1:1 of the additive and the nicotine actually reacts with the nicotine in the optimized molar ratio of each acid in the formula, namely completely reacts, is optimal in three proportions in the aspect of addiction elimination, but has stronger throat-hitting feeling aiming at the favor of part of old smokers, and the throat-hitting feeling of the other three proportions is more obvious.
The second and third formulas of the embodiment are respectively used as additives to be mixed with the tobacco powder according to the mass ratio of 1.5 percent, a proper amount of propylene glycol is added to assist in stirring, the mixture is uniformly mixed and then is kept stand for 48 hours to be pressed into thin slices suitable for heating non-burning smoking sets, pure tobacco powder tabletting products are used as a control group to carry out more than ten blind tests on smokers, and feedback results show that the strength of smoking and addiction relief of samples using the formulas as additives is obviously improved, and the smoothness of the mouthfeel is improved.
The third formula of the embodiment is used as an additive, the third formula is uniformly sprayed on cured tobacco shreds in a mass ratio of 1%, 3% and 5%, the cured tobacco shreds are placed for 24 hours and rolled into tobacco cores for smoking, more than ten smokers perform blind tests by taking common cigarettes as a control group, and feedback results show that the smoothness of the mouthfeel of 3% and 5% tobacco core samples using the additive is obviously improved.
In addition, a single acid (such as lactic acid or levulinic acid) is used as an additive to prepare a tobacco powder tablet by mixing the tobacco powder with the single acid and the nicotine in a molar ratio of 1:1, the tobacco powder tablet is smoked, the first three throat choking times are found, the smoke is quickly dissipated, and the addiction relieving strength of subsequent smoking is remarkably reduced. The sample proportion only considers the matching of protons in the pure acid-base reaction, and does not consider that the monobasic non-aromatic acid needs to at least reach the molar ratio of 2:1 with nicotine to fully react due to the space structure of organic molecules so that the nicotine free base is fully neutralized and stabilized, and the formula of the application further accurately establishes the effective range of the organic acid used in the novel tobacco products. Meanwhile, the single acid is inferior to the combined acid in the effect of stabilizing nicotine and relieving addiction in the whole smoking process, so that the product can not continuously and stably release protonated nicotine in the whole smoking process, and the continuous and stable addiction relieving degree of a user is provided.
The invention uses different organic acid combinations, considers the molecular space structures of different acids and the proportion of three-dimensional combination with nicotine, and neutralizes nicotine free alkali in liquid atomized smoke most efficiently, so that the nicotine addiction eliminating efficiency and the taste balance in smoke are improved under the condition that the nicotine concentration of the product is reduced.
In addition to the above embodiments, the present invention also includes other embodiments, and all technical solutions formed by equivalent transformation or equivalent replacement should fall within the protection scope of the claims of the present invention.
Claims (10)
1. An additive for a tobacco product, characterized by: comprises an organic acid and a solvent, wherein the organic acid can provide H + Protonic acid selected from two or more of monobasic organic acid, dibasic organic acid and tribasic organic acid, and the additive is used in the amount of H + The acid-base neutralization reaction of the protons with the N neutralizes at least 30% of the total nicotine nitrogen content of the tobacco product.
2. An additive for a tobacco product according to claim 1, characterized in that: the organic acid is selected from two or more of saturated carbon chain carboxylic acid, unsaturated carbon chain carboxylic acid, alpha-hydroxy acid, keto acid, and aromatic acid.
3. An additive for a tobacco product according to claim 1, characterized in that: the organic acid is selected from two or more of lactic acid, tartaric acid, citric acid, levulinic acid, malic acid, pyruvic acid, salicylic acid, acetic acid, propionic acid and butyric acid.
4. An additive for a tobacco product according to claim 1, characterized in that: the monobasic organic acid accounts for 50 to 99 weight percent of the total organic acid; or the dibasic organic acid accounts for 10-99 wt% of the total organic acid; or the ternary organic acid accounts for 10-99 wt% of the total organic acid.
5. An additive for a tobacco product according to claim 1, characterized in that: the solvent is one or more of propylene glycol, glycerol, water and ethanol.
6. An additive for a tobacco product according to claim 1, characterized in that: also includes a cosolvent.
7. Additive for tobacco products according to claim 6, characterized in that: the cosolvent is water, and the addition amount of the water as the cosolvent in the additive is not higher than 5 wt%;
or the cosolvent is selected from one or more of ethanol, propanol, butanol, pentanol, ethyl acetate and ethyl lactate, and the addition amount of the cosolvent in the additive is not higher than 1 wt%.
8. A process for the preparation of an additive as claimed in any one of claims 1 to 7, wherein: and sequentially adding the organic acid into the solvent, adding the cosolvent according to needs, and stirring until the organic acid is completely dissolved to obtain the additive.
9. The method of claim 8, wherein: the dissolving temperature is not higher than 100 ℃, and the stirring mode is selected from mechanical stirring, mechanical oscillation or ultrasonic oscillation.
10. Use of an additive according to any one of claims 1 to 7, wherein: the additive is added into tobacco product according to H in the additive + The molar ratio of protons to nicotine in the tobacco product is set to 0.6: 1-3: 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110230583.7A CN114983001A (en) | 2021-03-02 | 2021-03-02 | Additive for tobacco products, preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110230583.7A CN114983001A (en) | 2021-03-02 | 2021-03-02 | Additive for tobacco products, preparation method and application thereof |
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| CN114983001A true CN114983001A (en) | 2022-09-02 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115590240A (en) * | 2022-10-21 | 2023-01-13 | 广东中烟工业有限责任公司（Cn） | Preparation method and product of heated cigarette for regulating nicotine slow-release effect |
| WO2024066095A1 (en) * | 2022-09-28 | 2024-04-04 | 深圳市真味生物科技有限公司 | Nicotine salt and atomized liquid thereof, vape cartridge and use |
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| US4830028A (en) * | 1987-02-10 | 1989-05-16 | R. J. Reynolds Tobacco Company | Salts provided from nicotine and organic acid as cigarette additives |
| CA3143647A1 (en) * | 2013-05-06 | 2014-11-13 | Juul Labs, Inc. | Nicotine salt formulations for aerosol devices and methods thereof |
| US20160302471A1 (en) * | 2013-12-05 | 2016-10-20 | Pax Labs, Inc. | Nicotine liquid formulations for aerosol devices and methods thereof |
| WO2020089633A1 (en) * | 2018-11-01 | 2020-05-07 | Nicoventures Trading Limited | Aerosolisable formulation |
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| US4830028A (en) * | 1987-02-10 | 1989-05-16 | R. J. Reynolds Tobacco Company | Salts provided from nicotine and organic acid as cigarette additives |
| CA3143647A1 (en) * | 2013-05-06 | 2014-11-13 | Juul Labs, Inc. | Nicotine salt formulations for aerosol devices and methods thereof |
| US20160302471A1 (en) * | 2013-12-05 | 2016-10-20 | Pax Labs, Inc. | Nicotine liquid formulations for aerosol devices and methods thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2024066095A1 (en) * | 2022-09-28 | 2024-04-04 | 深圳市真味生物科技有限公司 | Nicotine salt and atomized liquid thereof, vape cartridge and use |
| CN115590240A (en) * | 2022-10-21 | 2023-01-13 | 广东中烟工业有限责任公司（Cn） | Preparation method and product of heated cigarette for regulating nicotine slow-release effect |
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