CN114949164A - Traditional Chinese medicine preparation for treating functional dyspepsia and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating functional dyspepsia and preparation method thereof Download PDFInfo
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- CN114949164A CN114949164A CN202210751691.3A CN202210751691A CN114949164A CN 114949164 A CN114949164 A CN 114949164A CN 202210751691 A CN202210751691 A CN 202210751691A CN 114949164 A CN114949164 A CN 114949164A
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and the traditional Chinese medicine comprises 25 parts of rhizoma atractylodis, 25 parts of phellodendron, 25 parts of dried orange peel, 25 parts of white paeony root, 25 parts of costustoot, 18 parts of mangnolia officinalis, 18 parts of dried ginger, 18 parts of perilla, 18 parts of emblic leafflower fruit, 12 parts of immature bitter orange, 12 parts of round cardamom, 8 parts of szechuan lovage rhizome, 8 parts of giant knotweed rhizome, 8 parts of codonopsis pilosula, 4 parts of cassia twig and 4 parts of divaricate saposhnikovia root, and is prepared according to the following method: weighing the traditional Chinese medicine raw materials according to the formula, adding the traditional Chinese medicine raw materials into a container, adding water to the container to soak the medicine surface for 10-20 minutes, adding water to submerge the medicine surface for 3-5 cm, decocting the medicine surface with strong fire until the medicine surface is boiled, then decocting the medicine surface with slow fire for 20-30 minutes, and taking filtrate; and then adding water to submerge the medicine surface by 3-5 cm, decocting with strong fire until the medicine surface is boiled, then decocting with slow fire for 15-20 minutes, removing residues, taking the filtrate, and combining the two filtrates, wherein the administration time is three times a day, and 300ml is taken each time. The invention has the advantages of obvious curative effect, safety, reliability, no toxic or side effect and wide clinical application prospect.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating functional dyspepsia and a preparation method thereof.
Background
Dyspepsia is a common group of symptoms that include epigastric pain or discomfort, including epigastric fullness, early satiety, burning sensation, belching, nausea and vomiting, as well as difficult to describe epigastric discomfort. Dyspepsia is classified into organic dyspepsia and functional dyspepsia according to the cause of dyspepsia symptoms. Undigested dyspepsia refers to a patient who has a complaint of dyspepsia symptoms but has not been examined by an endoscope or the like. The investigated dyspepsia means that it has been subjected to an endoscopic examination. Organic diseases such as peptic ulcer, reflux esophagitis and upper gastrointestinal tumor are excluded, and the disease is called non-ulcer dyspepsia, i.e. functional dyspepsia which is considered to be free of organic diseases and can explain dyspepsia symptoms.
The main symptoms of functional dyspepsia are epigastric pain, burning sensation of the upper abdomen, postprandial fullness or early satiety. Factors of daily living that affect gastrointestinal function to induce functional dyspepsia symptoms generally include three aspects: one is psychological and psychiatric adverse stress; secondly, poor eating habits, including stimulating food (coffee, strong tea, sweet food, greasy food, uncooked cold, etc.) and poor eating habits (fasting, frequent eating of stimulating food, irregular eating or overeating and the like); and thirdly, the influence of the ambient temperature.
The following problems are present in the prior art:
the harm that functional dyspepsia presents to patients is concentrated in discomfort caused by upper digestive tract symptoms and possible impact on quality of life. Some patients suffer from reduced food intake and reduced digestive absorption efficiency due to functional dyspepsia, resulting in various degrees of malnutrition (including incomplete nutritional components). In clinical work, a considerable part of patients with functional dyspepsia have a heavy psychological burden due to deviation of understanding of the disease, and thus, the functional dyspepsia is an important factor affecting the quality of life of the patients. Some patients have serious thought concerns and cancer risks for the chronic gastritis, particularly CAG, which is suggested to exist in endoscopy.
The pathophysiological processes resulting from functional dyspepsia are very complex and may involve gastric acid stimulation, gastric emptying disorders, altered gastrointestinal motor rhythms, high sensitivity of visceral sensory responses, etc.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine preparation for treating functional dyspepsia and a preparation method thereof, so as to solve the problems in the background technology.
The technical scheme of the invention is as follows: a traditional Chinese medicine preparation for treating functional dyspepsia and a preparation method thereof are prepared from the following traditional Chinese medicine raw materials in parts by weight: 25 parts of rhizoma atractylodis, 25 parts of phellodendron, 25 parts of dried orange peel, 25 parts of white peony root, 25 parts of costustoot, 18 parts of mangnolia officinalis, 18 parts of dried ginger, 18 parts of perilla, 18 parts of emblic leafflower fruit, 12 parts of immature bitter orange, 12 parts of round cardamom, 8 parts of ligusticum wallichii, 8 parts of polygonum cuspidatum, 8 parts of codonopsis pilosula, 4 parts of cassia twig and 4 parts of divaricate saposhnikovia root, and the preparation method comprises the following steps: weighing the traditional Chinese medicine raw materials according to the formula, adding the traditional Chinese medicine raw materials into a container, adding water to the container to soak the medicine surface for 10-20 minutes, adding water to submerge the medicine surface for 3-5 cm, decocting the medicine surface with strong fire until the medicine surface is boiled, then decocting the medicine surface with slow fire for 20-30 minutes, and taking filtrate; and then adding water to submerge the medicine surface by 3-5 cm, decocting with strong fire until the medicine surface is boiled, then decocting with slow fire for 15-20 minutes, removing residues, taking the filtrate, and combining the two filtrates, wherein the administration time is three times a day, and 300ml is taken each time.
The pharmacological analysis is as follows:
(1) rhizoma atractylodis: spleen, stomach and liver meridians are entered, spleen is strengthened, dampness is eliminated, depression is relieved, dirt is removed, and the traditional Chinese medicine is used for treating spleen encumbering due to excessive dampness, lassitude, sleepiness, abdominal distension, inappetence, vomiting, diarrhea, dysentery, malaria, phlegm retention, edema, qi-retention cold, wind-cold-dampness arthralgia, foot flaccidity and night blindness;
(2) phellodendron bark: bitter taste and cold nature. The traditional Chinese medicine composition has the effects of clearing heat, eliminating dampness, purging fire, detoxifying, treating heat dysentery, diarrhea, diabetes, jaundice, atrophy 36484, nocturnal emission, turbid urine, hemorrhoids, hematochezia, leucorrhea with reddish discharge, bone steaming, internal heat, conjunctival congestion, sore mouth and tongue, sore and ulcer pyogenic infections;
(3) dried orange peel: bitter and pungent with warm property, entering lung and spleen meridians, regulating qi and strengthening spleen, drying dampness and resolving phlegm, and can be used for treating fullness and distention in chest and stomach, anorexia, vomiting and diarrhea, cough and excessive phlegm.
(4) White peony root: bitter and sour, slight cold, entering liver and spleen channels, nourishing blood and liver, relieving pain, astringing yin and arresting sweating, treating pain in chest, abdomen and hypochondrium, dysentery, abdominal pain, spontaneous perspiration and night sweat, fever due to yin deficiency, irregular menstruation, metrorrhagia and leukorrhagia.
(5) Costustoot: 2, pungent taste; bitter; warm in nature, spleen-qi entering; large intestine and triple energizer channels, promoting qi circulation, relieving pain, invigorating spleen, resolving food stagnation, relieving chest and hypochondrium distention, abdominal distention and pain, belch, emesis, diarrhea, and dysentery with tenesmus, and can be used for treating chest and abdominal distention and pain, dysentery with tenesmus, dyspepsia, anorexia, qi deficiency, sudden deafness, snake and insect bite, and toothache;
(6) magnolia officinalis: bitter, pungent and warm, entering spleen, stomach, lung and large intestine channels, eliminating dampness and phlegm, descending qi and relieving fullness, and can be used for treating damp stagnation, abdominal distention, vomiting and diarrhea, food stagnation, abdominal distention, constipation, phlegm retention, asthma and cough;
(7) dried ginger: pungent and hot, spleen, stomach, kidney, heart and lung meridians entered, and dried ginger, warming spleen and stomach to dispel cold, returning yang to activate pulse, eliminating dampness and eliminating phlegm, and can be used for treating abdominal psychroalgia, emesis and diarrhea, cold limbs and slight pulse, phlegm retention and cough and asthma;
(8) purple perilla: dredging heart channel, invigorating spleen and stomach, relieving exterior syndrome, dispelling cold, regulating qi-flowing, harmonizing ying, treating common cold and wind cold, aversion to cold and fever, cough, asthma, fullness and distention in chest and abdomen, threatened abortion;
(9) emblic leafflower fruit: sweet, sour, astringent and cool, and can enter lung and stomach channels, clear heat and cool blood, promote digestion and invigorate stomach, promote the production of body fluid and relieve cough, and can be used for treating blood heat and blood stasis, dyspepsia, abdominal distention, cough, laryngalgia and dry mouth;
(10) immature bitter orange: bitter, pungent and cold herbs enter spleen, stomach, liver and heart meridians, and the main effects are: stagnation, abdominal distention, pain, constipation, dysentery, abdominal distention, chest distress, gastroptosis, uterine prolapse, and proctoptosis;
(11) round cardamom: pungent and warm, enter lung, spleen and stomach meridians, resolve dampness and relieve stuffiness, promote qi circulation and warm middle energizer, stimulate appetite and promote digestion, and can be used for treating damp turbidity obstruction in middle energizer, anorexia, early stage of damp-warm, chest distress and no hunger, vomiting due to cold-dampness, distending pain in chest and abdomen, and indigestion;
(12) ligusticum wallichii: the ligusticum wallichii is a traditional Chinese medicine plant, is usually used for promoting blood circulation and promoting qi circulation, dispelling wind and relieving pain, is pungent, warm, fragrant and dry, is walking without guarding, can disperse, can ascend to the vertex and enter the blood system, can descend to the blood sea, has wide effects of promoting blood circulation and removing blood stasis, is suitable for blood stasis to block various diseases, dispels wind and relieves pain, has good effects, can treat headache and rheumatalgia and other symptoms, is used as a qi medicine in blood, has the functions of lively dispersing, relieving depression, reaching, relieving pain and the like, is pungent and temperature-rising to disperse, and is not suitable for people with yin deficiency and yang excess and liver yang excess, and is contraindicated for pregnant women;
(13) giant knotweed rhizome: slightly bitter and cold, entering liver, gallbladder and lung channels, dispelling wind and promoting diuresis, removing blood stasis and relieving pain, relieving cough and reducing phlegm, and can be used for treating arthralgia, damp-heat jaundice, amenorrhea, abdominal mass, scald due to hot water and fire, traumatic injury, carbuncle, swelling, sore and toxic materials, cough and excessive phlegm;
(14) codonopsis pilosula: sweet and neutral, enter spleen and lung channels, tonify middle-jiao and Qi, invigorate spleen and benefit lung, and are used for treating spleen and lung weakness, short breath and palpitation, poor appetite and loose stool, asthenic asthma and cough, internal heat and diabetes;
(15) cassia twig: pungent, sweet and warm, enter heart, lung and bladder meridians, induce sweat and release muscles, warm and dredge meridians, support yang and transform qi, and calm the Chong and descend qi, and can be used for treating wind-cold type common cold, abdominal psychroalgia, amenorrhea due to blood cold, arthralgia, phlegm retention, edema, palpitation and galloping-pang;
(16) wind prevention: pungent, sweet and warm, enter bladder, liver and spleen meridians, relieve exterior syndrome, dispel wind, eliminate dampness and relieve spasm, and can be used for treating common cold, headache, rheumatalgia, rubella pruritus and tetanus.
Also included are case selection and efficacy criteria, the case selection: selecting 100 diagnosed functional dyspepsia patients as a traditional Chinese medicine preparation for treating functional dyspepsia, and carrying out clinical observation on 52 male patients, 48 female patients, 25-75 years old, 48.3 years old on average, 3 months old with the shortest disease course, 9 years old with the longest disease course and 4.9 years on average, wherein the traditional Chinese medicine preparation is orally taken 2 times a day, 1 time in the morning and evening and 300ml each time, 1 course of treatment in seven days, 1 course of treatment on a light person and 2-3 courses of treatment on a heavy person; the curative effect standard is as follows: and (3) curing: the symptoms such as upper abdominal pain, upper abdominal burning sensation, postprandial fullness or early satiety and the like disappear, and the stomach power returns to normal; the effect is shown: the symptoms are relieved, and the gastric motility is recovered; and (4) invalidation: the symptoms are not obviously improved after the treatment.
The traditional Chinese medicine used by the traditional Chinese medicine preparation conforms to the regulations of the national drug code of the people's republic of China, is safe and reliable, has the effects of promoting gastrointestinal motility and relieving dyspepsia and the like by combining various medicines, and has the characteristics of definite curative effect, quick response, high cure rate, no side effect and the like when being used for treating functional dyspepsia.
The invention also provides a preparation method of the traditional Chinese medicine preparation for treating functional dyspepsia, which comprises the following steps:
s1: 25 parts of rhizoma atractylodis, 25 parts of phellodendron, 25 parts of dried orange peel, 25 parts of white peony root, 25 parts of costustoot, 18 parts of mangnolia officinalis, 18 parts of dried ginger, 18 parts of perilla, 18 parts of emblic leafflower fruit, 12 parts of immature bitter orange, 12 parts of round cardamom, 8 parts of ligusticum wallichii, 8 parts of polygonum cuspidatum, 8 parts of codonopsis pilosula, 4 parts of cassia twig and 4 parts of divaricate saposhnikovia root, and the preparation method comprises the following steps:
s2: weighing the traditional Chinese medicine raw materials according to the formula, adding the traditional Chinese medicine raw materials into a container, adding water to the container, and soaking the traditional Chinese medicine raw materials for 10-20 minutes after the traditional Chinese medicine raw materials are soaked on the medicine surface;
s3: adding water to submerge the powder by 3-5 cm, decocting with strong fire until the powder is boiled, then decocting with slow fire for 20-30 minutes, and taking the filtrate;
s4: and then adding water to submerge the medicine surface by 3-5 cm, decocting with strong fire until the medicine surface is boiled, then decocting with slow fire for 15-20 minutes, removing residues, taking the filtrate, and combining the two filtrates.
The invention provides a traditional Chinese medicine preparation for treating functional dyspepsia and a preparation method thereof through improvement, and compared with the prior art, the traditional Chinese medicine preparation has the following improvement and advantages:
the invention has the advantages of obvious curative effect, safety, reliability, no toxic or side effect and wide clinical application prospect.
Drawings
The invention is further explained below with reference to the figures and examples:
FIG. 1 is a flow chart of the preparation of the present invention.
Detailed Description
The present invention will be described in detail with reference to fig. 1, and the technical solutions in the embodiments of the present invention will be clearly and completely described, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a traditional Chinese medicine preparation for treating functional dyspepsia and a preparation method thereof through improvement, and the traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine raw materials in parts by weight as shown in figure 1: 25 parts of rhizoma atractylodis, 25 parts of phellodendron, 25 parts of dried orange peel, 25 parts of white peony root, 25 parts of costustoot, 18 parts of mangnolia officinalis, 18 parts of dried ginger, 18 parts of perilla, 18 parts of emblic leafflower fruit, 12 parts of immature bitter orange, 12 parts of round cardamom, 8 parts of ligusticum wallichii, 8 parts of polygonum cuspidatum, 8 parts of codonopsis pilosula, 4 parts of cassia twig and 4 parts of divaricate saposhnikovia root, and the preparation method comprises the following steps: weighing the traditional Chinese medicine raw materials according to the formula, adding the traditional Chinese medicine raw materials into a container, adding water to the container to soak the medicine surface for 10-20 minutes, adding water to submerge the medicine surface for 3-5 cm, decocting the medicine surface with strong fire until the medicine surface is boiled, then decocting the medicine surface with slow fire for 20-30 minutes, and taking filtrate; and then adding water to submerge the medicine surface by 3-5 cm, decocting with strong fire until the medicine surface is boiled, then decocting with slow fire for 15-20 minutes, removing residues, taking the filtrate, and combining the two filtrates, wherein the administration time is three times a day, and 300ml is taken each time.
The pharmacological analysis is as follows:
(1) rhizoma atractylodis: spleen, stomach and liver meridians, spleen invigorating, dampness eliminating, depression relieving, dirt removing, dampness encumbering the spleen, listlessness, abdominal distention, anorexia, emesis, diarrhea, dysentery, malaria, phlegm retention, edema,
common cold due to seasonal febrile disease, arthralgia due to wind-cold-dampness, foot flaccidity, and night blindness;
(2) and (3) golden cypress: bitter taste and cold nature. The traditional Chinese medicine composition has the effects of clearing heat, eliminating dampness, purging fire, detoxifying, treating heat dysentery, diarrhea, diabetes, jaundice, atrophy 36484, nocturnal emission, turbid urine, hemorrhoids, hematochezia, leucorrhea with reddish discharge, bone steaming, internal heat, conjunctival congestion, sore mouth and tongue, sore and ulcer pyogenic infections;
(3) dried orange peel: bitter and pungent with warm property, entering lung and spleen meridians, regulating qi and strengthening spleen, drying dampness and resolving phlegm, and can be used for treating fullness and distention in chest and stomach, anorexia, vomiting and diarrhea, cough and excessive phlegm.
(4) White peony root: bitter and sour, slight cold, entering liver and spleen channels, nourishing blood and liver, relieving pain, astringing yin and arresting sweating, treating pain in chest, abdomen and hypochondrium, dysentery, abdominal pain, spontaneous perspiration and night sweat, fever due to yin deficiency, irregular menstruation, metrorrhagia and leukorrhagia.
(5) Costustoot: 2, pungent taste; bitter; warm in nature, spleen-qi entering; large intestine and triple energizer channels, promoting qi circulation, relieving pain, invigorating spleen, resolving food stagnation, relieving chest and hypochondrium distention, abdominal distention and pain, belch, emesis, diarrhea, and dysentery with tenesmus, and can be used for treating chest and abdominal distention and pain, dysentery with tenesmus, dyspepsia, anorexia, qi deficiency, sudden deafness, snake and insect bite, and toothache;
(6) magnolia officinalis: bitter, pungent and warm, entering spleen, stomach, lung and large intestine channels, eliminating dampness and phlegm, descending qi and relieving fullness, and can be used for treating damp stagnation, abdominal distention, vomiting and diarrhea, food stagnation, abdominal distention, constipation, phlegm retention, asthma and cough;
(7) dried ginger: pungent and hot, spleen, stomach, kidney, heart and lung meridians entered, and dried ginger, warming spleen and stomach to dispel cold, returning yang to activate pulse, eliminating dampness and eliminating phlegm, and can be used for treating abdominal psychroalgia, emesis and diarrhea, cold limbs and slight pulse, phlegm retention and cough and asthma;
(8) purple perilla: dredging heart channel, invigorating spleen and stomach, relieving exterior syndrome, dispelling cold, regulating qi-flowing, harmonizing ying, treating common cold and wind cold, aversion to cold and fever, cough, asthma, fullness and distention in chest and abdomen, threatened abortion;
(9) emblic leafflower fruit: sweet, sour, astringent and cool, and can enter lung and stomach channels, clear heat and cool blood, promote digestion and invigorate stomach, promote the production of body fluid and relieve cough, and can be used for treating blood heat and blood stasis, dyspepsia, abdominal distention, cough, laryngalgia and dry mouth;
(10) immature bitter orange: bitter, pungent and cold herbs enter spleen, stomach, liver and heart meridians, and the main effects are: stagnation, abdominal distention, pain, constipation, dysentery, abdominal distention, chest distress, gastroptosis, uterine prolapse, and proctoptosis;
(11) round cardamom: pungent and warm, enter lung, spleen and stomach meridians, resolve dampness and relieve stuffiness, promote qi circulation and warm middle energizer, stimulate appetite and promote digestion, and can be used for treating damp turbidity obstruction in middle energizer, anorexia, early stage of damp-warm, chest distress and no hunger, vomiting due to cold-dampness, distending pain in chest and abdomen, and indigestion;
(12) ligusticum wallichii: the ligusticum wallichii is a traditional Chinese medicine plant, is usually used for promoting blood circulation and promoting qi circulation, dispelling wind and relieving pain, is pungent, warm, fragrant and dry, is walking without guarding, can disperse, can ascend to the vertex and enter the blood system, can descend to the blood sea, has wide effects of promoting blood circulation and removing blood stasis, is suitable for blood stasis to block various diseases, dispels wind and relieves pain, has good effects, can treat headache and rheumatalgia and other symptoms, is used as a qi medicine in blood, has the functions of lively dispersing, relieving depression, reaching, relieving pain and the like, is pungent and temperature-rising to disperse, and is not suitable for people with yin deficiency and yang excess and liver yang excess, and is contraindicated for pregnant women;
(13) giant knotweed rhizome: slightly bitter and cold, entering liver, gallbladder and lung channels, dispelling wind and promoting diuresis, removing blood stasis and relieving pain, relieving cough and reducing phlegm, and can be used for treating arthralgia, damp-heat jaundice, amenorrhea, abdominal mass, scald due to hot water and fire, traumatic injury, carbuncle, swelling, sore and toxic materials, cough and excessive phlegm;
(14) codonopsis pilosula: sweet and neutral, enter spleen and lung channels, tonify middle-jiao and Qi, invigorate spleen and benefit lung, and are used for treating spleen and lung weakness, short breath and palpitation, poor appetite and loose stool, asthenic asthma and cough, internal heat and diabetes;
(15) cassia twig: pungent, sweet and warm, enter heart, lung and bladder meridians, induce sweat and release muscles, warm and dredge meridians, support yang and transform qi, and calm the Chong and descend qi, and can be used for treating wind-cold type common cold, abdominal psychroalgia, amenorrhea due to blood cold, arthralgia, phlegm retention, edema, palpitation and galloping-pang;
(16) wind prevention: pungent, sweet and warm, enter bladder, liver and spleen meridians, relieve exterior syndrome, dispel wind, eliminate dampness and relieve spasm, and can be used for treating common cold, headache, rheumatalgia, rubella pruritus and tetanus.
Also included are case selection and efficacy criteria, the case selection: selecting 100 diagnosed functional dyspepsia patients as a traditional Chinese medicine preparation for treating functional dyspepsia, and carrying out clinical observation on 52 male patients, 48 female patients, 25-75 years old, 48.3 years old on average, 3 months old with the shortest disease course, 9 years old with the longest disease course and 4.9 years on average, wherein the traditional Chinese medicine preparation is orally taken 2 times a day, 1 time in the morning and evening and 300ml each time, 1 course of treatment in seven days, 1 course of treatment on a light person and 2-3 courses of treatment on a heavy person; the curative effect standard is as follows: and (3) curing: the symptoms such as upper abdominal pain, upper abdominal burning sensation, postprandial fullness or early satiety and the like disappear, and the stomach power returns to normal; the effect is shown: the symptoms are relieved, and the gastric motility is recovered; and (4) invalidation: the symptoms are not obviously improved after the treatment.
The traditional Chinese medicine used by the traditional Chinese medicine preparation conforms to the regulations of the national drug code of the people's republic of China, is safe and reliable, has the effects of promoting gastrointestinal motility and relieving dyspepsia and the like by combining various medicines, and has the characteristics of definite curative effect, quick response, high cure rate, no side effect and the like when being used for treating functional dyspepsia.
The invention also provides a preparation method of the traditional Chinese medicine preparation for treating functional dyspepsia, which comprises the following steps:
s1: 25 parts of rhizoma atractylodis, 25 parts of phellodendron, 25 parts of dried orange peel, 25 parts of white peony root, 25 parts of costustoot, 18 parts of mangnolia officinalis, 18 parts of dried ginger, 18 parts of perilla, 18 parts of emblic leafflower fruit, 12 parts of immature bitter orange, 12 parts of round cardamom, 8 parts of ligusticum wallichii, 8 parts of polygonum cuspidatum, 8 parts of codonopsis pilosula, 4 parts of cassia twig and 4 parts of divaricate saposhnikovia root, and the preparation method comprises the following steps:
s2: weighing the traditional Chinese medicine raw materials according to the formula, adding the traditional Chinese medicine raw materials into a container, adding water to the container, and soaking the traditional Chinese medicine raw materials for 10-20 minutes after the traditional Chinese medicine raw materials are soaked on the medicine surface;
s3: adding water to submerge the powder by 3-5 cm, decocting with strong fire until the powder is boiled, then decocting with slow fire for 20-30 minutes, and taking the filtrate;
s4: and then adding water to submerge the medicine surface by 3-5 cm, decocting with strong fire until the medicine surface is boiled, then decocting with slow fire for 15-20 minutes, removing residues, taking the filtrate, and combining the two filtrates.
The pharmacological analysis is as follows:
(1) rhizoma atractylodis: spleen, stomach and liver meridians are entered, spleen is strengthened, dampness is eliminated, depression is relieved, dirt is removed, and the traditional Chinese medicine is used for treating spleen encumbering due to excessive dampness, lassitude, sleepiness, abdominal distension, inappetence, vomiting, diarrhea, dysentery, malaria, phlegm retention, edema, qi-retention cold, wind-cold-dampness arthralgia, foot flaccidity and night blindness;
(2) phellodendron bark: bitter taste and cold nature. The traditional Chinese medicine composition has the effects of clearing heat, eliminating dampness, purging fire, detoxifying, treating heat dysentery, diarrhea, diabetes, jaundice, atrophy 36484, nocturnal emission, turbid urine, hemorrhoids, hematochezia, leucorrhea with reddish discharge, bone steaming, internal heat, conjunctival congestion, sore mouth and tongue, sore and ulcer pyogenic infections;
(3) dried orange peel: bitter and pungent with warm property, entering lung and spleen meridians, regulating qi and strengthening spleen, drying dampness and resolving phlegm, and can be used for treating fullness and distention in chest and stomach, anorexia, vomiting and diarrhea, cough and excessive phlegm.
(4) White peony root: bitter and sour, slight cold, entering liver and spleen channels, nourishing blood and liver, relieving pain, astringing yin and arresting sweating, treating pain in chest, abdomen and hypochondrium, dysentery, abdominal pain, spontaneous perspiration and night sweat, fever due to yin deficiency, irregular menstruation, metrorrhagia and leukorrhagia.
(5) Costustoot: 2, pungent taste; bitter; warm in nature, spleen-qi entering; large intestine and triple energizer channels, promoting qi circulation, relieving pain, invigorating spleen, resolving food stagnation, relieving chest and hypochondrium distention, abdominal distention and pain, belch, emesis, diarrhea, and dysentery with tenesmus, and can be used for treating chest and abdominal distention and pain, dysentery with tenesmus, dyspepsia, anorexia, qi deficiency, sudden deafness, snake and insect bite, and toothache;
(6) magnolia officinalis: bitter, pungent and warm, entering spleen, stomach, lung and large intestine channels, eliminating dampness and phlegm, descending qi and relieving fullness, and can be used for treating damp stagnation, abdominal distention, vomiting and diarrhea, food stagnation, abdominal distention, constipation, phlegm retention, asthma and cough;
(7) dried ginger: pungent and hot, spleen, stomach, kidney, heart and lung meridians entered, and dried ginger, warming spleen and stomach to dispel cold, returning yang to activate pulse, eliminating dampness and eliminating phlegm, and can be used for treating abdominal psychroalgia, emesis and diarrhea, cold limbs and slight pulse, phlegm retention and cough and asthma;
(8) purple perilla: dredging heart channel, invigorating spleen and stomach, relieving exterior syndrome, dispelling cold, regulating qi-flowing, harmonizing ying, treating common cold and wind cold, aversion to cold and fever, cough, asthma, fullness and distention in chest and abdomen, threatened abortion;
(9) emblic leafflower fruit: sweet, sour, astringent and cool, and can enter lung and stomach channels, clear heat and cool blood, promote digestion and invigorate stomach, promote the production of body fluid and relieve cough, and can be used for treating blood heat and blood stasis, dyspepsia, abdominal distention, cough, laryngalgia and dry mouth;
(10) immature bitter orange: bitter, pungent and cold herbs enter spleen, stomach, liver and heart meridians, and the main effects are: stagnation, abdominal distention, pain, constipation, dysentery, abdominal distention, chest distress, gastroptosis, uterine prolapse, and proctoptosis;
(11) round cardamom: pungent and warm, enter lung, spleen and stomach meridians, resolve dampness and relieve stuffiness, promote qi circulation and warm middle energizer, stimulate appetite and promote digestion, and can be used for treating damp turbidity obstruction in middle energizer, anorexia, early stage of damp-warm, chest distress and no hunger, vomiting due to cold-dampness, distending pain in chest and abdomen, and indigestion;
(12) ligusticum wallichii: the ligusticum wallichii is a traditional Chinese medicine plant, is usually used for promoting blood circulation and promoting qi circulation, dispelling wind and relieving pain, is pungent, warm, fragrant and dry, is walking without guarding, can disperse, can ascend to the vertex and enter the blood system, can descend to the blood sea, has wide effects of promoting blood circulation and removing blood stasis, is suitable for blood stasis to block various diseases, dispels wind and relieves pain, has good effects, can treat headache and rheumatalgia and other symptoms, is used as a qi medicine in blood, has the functions of lively dispersing, relieving depression, reaching, relieving pain and the like, is pungent and temperature-rising to disperse, and is not suitable for people with yin deficiency and yang excess and liver yang excess, and is contraindicated for pregnant women;
(13) giant knotweed rhizome: slightly bitter and cold, entering liver, gallbladder and lung channels, dispelling wind and promoting diuresis, removing blood stasis and relieving pain, relieving cough and reducing phlegm, and can be used for treating arthralgia, damp-heat jaundice, amenorrhea, abdominal mass, scald due to hot water and fire, traumatic injury, carbuncle, swelling, sore and toxic materials, cough and excessive phlegm;
(14) codonopsis pilosula: sweet and neutral, enter spleen and lung channels, tonify middle-jiao and Qi, invigorate spleen and benefit lung, and are used for treating spleen and lung weakness, short breath and palpitation, poor appetite and loose stool, asthenic asthma and cough, internal heat and diabetes;
(15) cassia twig: pungent, sweet and warm, enter heart, lung and bladder meridians, induce sweat and release muscles, warm and dredge meridians, support yang and transform qi, and calm the Chong and descend qi, and can be used for treating wind-cold type common cold, abdominal psychroalgia, amenorrhea due to blood cold, arthralgia, phlegm retention, edema, palpitation and galloping-pang;
(16) wind prevention: pungent, sweet and warm, enter bladder, liver and spleen meridians, relieve exterior syndrome, dispel wind, eliminate dampness and relieve spasm, and can be used for treating common cold, headache, rheumatalgia, rubella pruritus and tetanus.
Also included are case selection and efficacy criteria, the case selection: selecting 100 diagnosed functional dyspepsia patients as a traditional Chinese medicine preparation for treating functional dyspepsia, and carrying out clinical observation on 52 male patients, 48 female patients, 25-75 years old, 48.3 years old on average, 3 months old with the shortest disease course, 9 years old with the longest disease course and 4.9 years on average, wherein the traditional Chinese medicine preparation is orally taken 2 times a day, 1 time in the morning and evening and 300ml each time, 1 course of treatment in seven days, 1 course of treatment on a light person and 2-3 courses of treatment on a heavy person; the curative effect standard is as follows: and (3) curing: the symptoms such as upper abdominal pain, upper abdominal burning sensation, postprandial fullness or early satiety and the like disappear, and the stomach power returns to normal; the effect is shown: the symptoms are relieved, and the gastric motility is recovered; and (4) invalidation: the symptoms are not obviously improved after the treatment.
The traditional Chinese medicine used by the traditional Chinese medicine preparation conforms to the code of the Chinese people's republic of China, the medicine is safe and reliable, the medicines are combined together to have the effects of promoting gastrointestinal motility, relieving dyspepsia and the like, and the traditional Chinese medicine preparation for treating functional dyspepsia has the characteristics of definite curative effect, quick response, high cure rate, no side effect and the like.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (5)
1. A traditional Chinese medicine preparation for treating functional dyspepsia is characterized in that: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 25 parts of rhizoma atractylodis, 25 parts of phellodendron, 25 parts of dried orange peel, 25 parts of white peony root, 25 parts of costustoot, 18 parts of mangnolia officinalis, 18 parts of dried ginger, 18 parts of perilla, 18 parts of emblic leafflower fruit, 12 parts of immature bitter orange, 12 parts of round cardamom, 8 parts of ligusticum wallichii, 8 parts of polygonum cuspidatum, 8 parts of codonopsis pilosula, 4 parts of cassia twig and 4 parts of divaricate saposhnikovia root, and the preparation method comprises the following steps: weighing the traditional Chinese medicine raw materials according to the formula, adding the traditional Chinese medicine raw materials into a container, adding water to the container to soak the medicine surface for 10-20 minutes, adding water to submerge the medicine surface for 3-5 cm, decocting the medicine surface with strong fire until the medicine surface is boiled, then decocting the medicine surface with slow fire for 20-30 minutes, and taking filtrate; and then adding water to submerge the medicine surface by 3-5 cm, decocting with strong fire until the medicine surface is boiled, then decocting with slow fire for 15-20 minutes, removing residues, taking the filtrate, and combining the two filtrates, wherein the administration time is three times a day, and 300ml is taken each time.
2. The traditional Chinese medicine preparation for treating functional dyspepsia according to claim 1, which is characterized in that: the pharmacological analysis is as follows:
(1) rhizoma atractylodis: spleen, stomach and liver meridians are entered, spleen is strengthened, dampness is eliminated, depression is relieved, dirt is removed, and the traditional Chinese medicine is used for treating spleen encumbering due to excessive dampness, lassitude, sleepiness, abdominal distension, inappetence, vomiting, diarrhea, dysentery, malaria, phlegm retention, edema, qi-retention cold, wind-cold-dampness arthralgia, foot flaccidity and night blindness;
(2) phellodendron bark: bitter taste and cold nature. The traditional Chinese medicine composition has the effects of clearing heat, eliminating dampness, purging fire, detoxifying, treating heat dysentery, diarrhea, diabetes, jaundice, atrophy 36484, nocturnal emission, turbid urine, hemorrhoids, hematochezia, leucorrhea with reddish discharge, bone steaming, internal heat, conjunctival congestion, sore mouth and tongue, sore and ulcer pyogenic infections;
(3) dried orange peel: bitter and pungent with warm property, entering lung and spleen meridians, regulating qi and strengthening spleen, drying dampness and resolving phlegm, and can be used for treating fullness and distention in chest and stomach, anorexia, vomiting and diarrhea, cough and excessive phlegm.
(4) White peony root: bitter and sour, slight cold, entering liver and spleen channels, nourishing blood and liver, relieving pain, astringing yin and arresting sweating, treating pain in chest, abdomen and hypochondrium, dysentery, abdominal pain, spontaneous perspiration and night sweat, fever due to yin deficiency, irregular menstruation, metrorrhagia and leukorrhagia.
(5) Costustoot: 2, pungent taste; bitter; warm in nature, spleen-qi entering; large intestine and triple energizer channels, promoting qi circulation, relieving pain, invigorating spleen, resolving food stagnation, relieving chest and hypochondrium distention, abdominal distention and pain, belch, emesis, diarrhea, and dysentery with tenesmus, and can be used for treating chest and abdominal distention and pain, dysentery with tenesmus, dyspepsia, anorexia, qi deficiency, sudden deafness, snake and insect bite, and toothache;
(6) magnolia officinalis: bitter, pungent and warm, entering spleen, stomach, lung and large intestine channels, eliminating dampness and phlegm, descending qi and relieving fullness, and can be used for treating damp stagnation, abdominal distention, vomiting and diarrhea, food stagnation, abdominal distention, constipation, phlegm retention, asthma and cough;
(7) dried ginger: pungent and hot, spleen, stomach, kidney, heart and lung meridians entered, and dried ginger, warming spleen and stomach to dispel cold, returning yang to activate pulse, eliminating dampness and eliminating phlegm, and can be used for treating abdominal psychroalgia, emesis and diarrhea, cold limbs and slight pulse, phlegm retention and cough and asthma;
(8) purple perilla: dredging heart channel, invigorating spleen and stomach, relieving exterior syndrome, dispelling cold, regulating qi-flowing, harmonizing ying, treating common cold and wind cold, aversion to cold and fever, cough, asthma, fullness and distention in chest and abdomen, threatened abortion;
(9) emblic leafflower fruit: sweet, sour, astringent and cool, and can enter lung and stomach channels, clear heat and cool blood, promote digestion and invigorate stomach, promote the production of body fluid and relieve cough, and can be used for treating blood heat and blood stasis, dyspepsia, abdominal distention, cough, laryngalgia and dry mouth;
(10) immature bitter orange: bitter, pungent and cold herbs enter spleen, stomach, liver and heart meridians, and the main effects are: stagnation, abdominal distention, pain, constipation, dysentery, abdominal distention, chest distress, gastroptosis, uterine prolapse, and proctoptosis;
(11) round cardamom: pungent and warm, enter lung, spleen and stomach meridians, resolve dampness and relieve stuffiness, promote qi circulation and warm middle energizer, stimulate appetite and promote digestion, and can be used for treating damp turbidity obstruction in middle energizer, anorexia, early stage of damp-warm, chest distress and no hunger, vomiting due to cold-dampness, distending pain in chest and abdomen, and indigestion;
(12) ligusticum wallichii: the ligusticum wallichii is a traditional Chinese medicine plant, is usually used for promoting blood circulation and promoting qi circulation, dispelling wind and relieving pain, is pungent, warm, fragrant and dry, is walking without guarding, can disperse, can ascend to the vertex and enter the blood system, can descend to the blood sea, has wide effects of promoting blood circulation and removing blood stasis, is suitable for blood stasis to block various diseases, dispels wind and relieves pain, has good effects, can treat headache and rheumatalgia and other symptoms, is used as a qi medicine in blood, has the functions of lively dispersing, relieving depression, reaching, relieving pain and the like, is pungent and temperature-rising to disperse, and is not suitable for people with yin deficiency and yang excess and liver yang excess, and is contraindicated for pregnant women;
(13) giant knotweed rhizome: slightly bitter and cold, entering liver, gallbladder and lung channels, dispelling wind and promoting diuresis, removing blood stasis and relieving pain, relieving cough and reducing phlegm, and can be used for treating arthralgia, damp-heat jaundice, amenorrhea, abdominal mass, scald due to hot water and fire, traumatic injury, carbuncle, swelling, sore and toxic materials, cough and excessive phlegm;
(14) codonopsis pilosula: sweet and neutral, enter spleen and lung channels, tonify middle-jiao and Qi, invigorate spleen and benefit lung, and are used for treating spleen and lung weakness, short breath and palpitation, poor appetite and loose stool, asthenic asthma and cough, internal heat and diabetes;
(15) cassia twig: pungent, sweet and warm, enter heart, lung and bladder meridians, induce sweat and release muscles, warm and dredge meridians, support yang and transform qi, and calm the Chong and descend qi, and can be used for treating wind-cold type common cold, abdominal psychroalgia, amenorrhea due to blood cold, arthralgia, phlegm retention, edema, palpitation and galloping-pang;
(16) wind prevention: pungent, sweet and warm, enter bladder, liver and spleen meridians, release exterior syndrome, dispel wind, remove dampness and relieve spasm, and can be used for treating cold, headache, rheumatalgia, rubella, pruritus and tetanus.
3. The traditional Chinese medicine preparation for treating functional dyspepsia according to claim 1, which is characterized in that: also included are case selection and efficacy criteria, the case selection: selecting 100 diagnosed functional dyspepsia patients as a traditional Chinese medicine preparation for treating functional dyspepsia, and carrying out clinical observation on 52 male patients, 48 female patients, 25-75 years old, 48.3 years old on average, 3 months old with the shortest disease course, 9 years old with the longest disease course and 4.9 years on average, wherein the traditional Chinese medicine preparation is orally taken 2 times a day, 1 time in the morning and evening and 300ml each time, 1 course of treatment in seven days, 1 course of treatment on a light person and 2-3 courses of treatment on a heavy person; the curative effect standard is as follows: and (3) curing: the symptoms such as upper abdominal pain, upper abdominal burning sensation, postprandial fullness or early satiety and the like disappear, and the stomach power returns to normal; the effect is shown: the symptoms are relieved, and the gastric motility is recovered; and (4) invalidation: the symptoms are not obviously improved after the treatment.
4. The traditional Chinese medicine preparation for treating functional dyspepsia according to claim 1, which is characterized in that: the traditional Chinese medicine used by the traditional Chinese medicine preparation conforms to the regulations of the national drug code of the people's republic of China, is safe and reliable, has the effects of promoting gastrointestinal motility and relieving dyspepsia and the like by combining various medicines, and has the characteristics of definite curative effect, quick response, high cure rate, no side effect and the like when being used for treating functional dyspepsia.
5. The method for preparing a Chinese medicinal preparation for treating functional dyspepsia according to any one of claims 1 to 4, wherein the method comprises the following steps: the preparation method comprises the following steps:
s1: 25 parts of rhizoma atractylodis, 25 parts of phellodendron, 25 parts of dried orange peel, 25 parts of white peony root, 25 parts of costustoot, 18 parts of mangnolia officinalis, 18 parts of dried ginger, 18 parts of perilla, 18 parts of emblic leafflower fruit, 12 parts of immature bitter orange, 12 parts of round cardamom, 8 parts of ligusticum wallichii, 8 parts of polygonum cuspidatum, 8 parts of codonopsis pilosula, 4 parts of cassia twig and 4 parts of divaricate saposhnikovia root, and the preparation method comprises the following steps:
s2: weighing the traditional Chinese medicine raw materials according to the formula, adding the traditional Chinese medicine raw materials into a container, adding water to the container, and soaking the traditional Chinese medicine raw materials for 10-20 minutes after the traditional Chinese medicine raw materials are soaked on the medicine surface;
s3: adding water to submerge the powder by 3-5 cm, decocting with strong fire until the powder is boiled, then decocting with slow fire for 20-30 minutes, and taking the filtrate;
s4, adding water to submerge the powder by 3-5 cm, decocting with strong fire until boiling, decocting with slow fire for 15-20 minutes, removing residues, taking filtrate, and mixing the two filtrates.
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| CN104161859A (en) * | 2014-05-29 | 2014-11-26 | 南京中山制药有限公司 | Traditional Chinese medicine composition for treating spleen and stomach diseases, and preparation method thereof |
| CN104524490A (en) * | 2014-12-10 | 2015-04-22 | 青岛市市立医院 | Traditional Chinese medicine preparation for treating functional dyspepsia and preparation method of traditional Chinese medicine preparation |
| CN105749198A (en) * | 2014-12-16 | 2016-07-13 | 青岛市黄岛区中医医院 | Traditional Chinese medicinal preparation for treating functional dyspepsia, and preparation method thereof |
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| CN104161859A (en) * | 2014-05-29 | 2014-11-26 | 南京中山制药有限公司 | Traditional Chinese medicine composition for treating spleen and stomach diseases, and preparation method thereof |
| CN104524490A (en) * | 2014-12-10 | 2015-04-22 | 青岛市市立医院 | Traditional Chinese medicine preparation for treating functional dyspepsia and preparation method of traditional Chinese medicine preparation |
| CN105749198A (en) * | 2014-12-16 | 2016-07-13 | 青岛市黄岛区中医医院 | Traditional Chinese medicinal preparation for treating functional dyspepsia, and preparation method thereof |
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