CN114941147A

CN114941147A - System device for realizing stable output of nitric oxide and output method thereof

Info

Publication number: CN114941147A
Application number: CN202110183873.0A
Authority: CN
Inventors: 耿翔; 赵杨波; 吴清; 孔维壮; 曹贵平
Original assignee: Nanjing Nuoling Biotechnology Co ltd
Current assignee: Nanjing Nuoling Biotechnology Co ltd
Priority date: 2021-02-08
Filing date: 2021-02-08
Publication date: 2022-08-26

Abstract

The invention provides a system device for realizing stable output of nitric oxide and an output method thereof, wherein the system device comprises a generating unit, a purifying unit and an output unit, wherein the generating unit comprises an electrolytic cell and a gas-liquid separator which are circularly connected; the output unit comprises a breathing simulation device; and after the electrolytic cell stops generating the nitric oxide, the gas-liquid separator removes the residual nitric oxide in the electrolytic cell. According to the invention, the gas-liquid separator circularly connected with the electrolytic cell is used for removing NO remained in the electrolytic cell after electrolysis is finished, so that the electrolyte and the electrode can be used for multiple times, and stable and efficient output of nitric oxide is realized; in addition, the output nitric oxide is regulated through the breathing simulation device, the output stability of the nitric oxide is ensured, and the device has the characteristics of high nitric oxide gas generation rate, stable output concentration and the like.

Description

System device for realizing stable output of nitric oxide and output method thereof

Technical Field

The invention belongs to the technical field of nitric oxide generation, relates to a system device for stably outputting nitric oxide, and particularly relates to a system device for realizing stable output of nitric oxide and an output method thereof.

Background

Nitric oxide is a gas that plays a role in transmitting important information and regulating cellular functions in the human body, and helps promote blood circulation in the body. It does not require any intermediary mechanism to rapidly diffuse across a biological membrane, transmitting the information produced by one cell to its surrounding cells. Nitric oxide has many biological functions, and is very involved in electron transfer reaction and redox process.

CN108751149A discloses a nitric oxide generating device, comprising: the first reduction cabin is communicated with the discharge cabin; the device comprises a discharge cabin, a gas source and a gas source, wherein the discharge cabin is used for generating a first reaction on a first gas entering the discharge cabin to obtain a second gas, and the second gas comprises nitric oxide and nitrogen dioxide; the first reduction cabin is used for reducing nitrogen dioxide in the second gas conveyed by the discharge cabin into nitric oxide to obtain third gas; wherein the concentration of nitric oxide in the third gas is greater than the concentration of nitric oxide in the second gas. The invention realizes that the cost is lower when the air is used as the raw material to prepare the nitric oxide, and the oxygen and the nitrogen in the air can fully react after the air passes through the discharge cabin and the first reduction cabin, thereby improving the concentration of the nitric oxide. However, there are problems such as unstable gas output.

CN109568745A discloses a medical nitric oxide gas supply system and method, comprising a nitric oxide gas generation subsystem and a gas concentration monitoring subsystem, wherein the gas concentration monitoring subsystem is used for monitoring the concentration of nitric oxide and nitrogen dioxide actually inhaled by a user and controlling the concentration of nitric oxide gas output by the nitric oxide generation subsystem by feedback of a monitoring value. But it has a problem that nitrogen dioxide inhalation is harmful to human body.

The existing nitric oxide generating system devices all have the problems of unstable gas output, low gas production rate and the like, so that the problem that how to ensure the stable gas output under the condition of ensuring that the nitric oxide generating system devices have high gas production rate is urgently needed to be solved at present.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide a system device for realizing stable output of nitric oxide and an output method thereof, which realize the quick output of nitric oxide through an electrolytic cell and a gas-liquid separator which are connected in a circulating way, ensure the stable output of nitric oxide by combining a breathing simulation device, and have the characteristics of high nitric oxide gas generation rate, stable output concentration and the like.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the invention provides a system device for realizing stable output of nitric oxide, which comprises a generating unit, a purifying unit and an output unit, wherein the generating unit comprises an electrolytic cell and a gas-liquid separator which are circularly connected; the output unit comprises a breathing simulation device; and after the electrolytic cell stops generating the nitric oxide, the gas-liquid separator removes the residual nitric oxide in the electrolytic cell.

According to the invention, NO remained in the electrolytic cell after the electrolysis is finished is removed through the gas-liquid separator circularly connected with the electrolytic cell, so that the harm of the remained NO to the electrolyte and the electrode is avoided, the electrolyte and the electrode can be used for multiple times, and the stable and efficient output of nitric oxide is realized; in addition, the output nitric oxide is regulated through the breathing simulation device, the output stability of the nitric oxide is ensured, and the device has the characteristics of high nitric oxide gas generation rate, stable output concentration and the like.

As a preferred embodiment of the present invention, the breathing simulation apparatus includes at least two breathing simulation modules.

Preferably, the breathing simulation assembly comprises a screw rod lifting piece and an air bag, and the screw rod lifting piece is used for pressing and lifting the air bag.

Preferably, the air bag is connected with a two-position three-way switching valve, and the air bag is connected to a working port of the two-position three-way switching valve.

Preferably, the air outlet end of the purification unit is respectively and independently connected to the inflation inlet of the two-position three-way switching valve.

Preferably, the output unit further comprises NO ₂ The gas outlets of two-position three-way switching valves in the breathing simulation device converge into one path to be connected with NO ₂ The screw rod lifting piece lifts the air bag, the air outlet is closed, the inflation inlet is opened, and air enters the air bag; the screw rod pulling piece presses the air bag, the air outlet is opened, the inflation inlet is closed, and the gas is discharged out of the air bag and passes through NO ₂ And discharging the conversion filter element device.

Preferably, a pressure sensor is arranged on the air bag and used for detecting the pressure in the air bag.

In the respiration simulation assembly, the air bag is pressed and pulled through the screw rod pulling piece to simulate the respiration process, the pressing degree of the screw rod pulling piece on the air bag is adjusted, and the nitric oxide gas output stability is further improved by matching with the respiration of users.

Preferably, said NO ₂ The conversion filter element device comprises a cylinder body; the cylinder is internally divided into at least two baffling cavities, the baffling cavities axially penetrate through the cylinder along the cylinder, and NO is filled in the baffling cavities ₂ One end of each of two adjacent baffling cavities is communicated with each other, and gas enters the cylinder body and flows through the baffling cavities in sequence in a serpentine baffling mode.

The invention leads the smoke to be in snake-shaped flow deflection in the cylinder body by arranging the multilayer flow deflection cavity, thereby improving NO ₂ The contact time and the contact area of the gas and the filter element material reduce the occupied area of the equipment.

Preferably, said NO ₂ The conversion filter element material comprises a carrier and reducing vitamins coated on the surface of the carrier.

Preferably, the carrier comprises one or a combination of at least two of silica gel, molecular sieve, alumina, sponge, cotton or foaming resin.

Preferably, the reducing vitamin comprises one or a combination of at least two of vitamin C, vitamin E or vitamin a.

Preferably, the carrier is coated with 5-50 g of reducing vitamin per 100g of carrier, such as 5g, 10g, 15g, 20g, 25g, 30g, 35g, 40g, 45g or 50 g.

As a preferred embodiment of the present invention, the NO is ₂ The air outlet end of the conversion filter element device is connected with a respirator through a breathing pipeline, and the breathing pipeline is divided into an independent incoming pipeline and an independent outgoing pipeline which are connected into the respirator.

Preferably, a standby device is further connected to the incoming line.

Preferably, the backup device comprises a gas cylinder which is connected into the incoming pipeline through a backup branch.

Preferably, a pressure reducing valve and a flow meter are sequentially arranged on the standby branch along the gas flow direction.

The standby device is connected, when the system device breaks down suddenly, the standby device is started, the problem that the device cannot work continuously is avoided, and the gas outlet device has the advantages of low cost, simplicity in operation, rapidness in gas outlet and the like.

As a preferred technical solution of the present invention, the system device further includes a nitrogen production unit, and the nitrogen production unit includes a filtering device and a nitrogen production device which are connected in sequence along a gas flow direction.

Preferably, the filtering device comprises a water vapor filter and a dust filter which are connected in sequence along the gas flow direction.

Preferably, the nitrogen making device comprises a nitrogen making membrane, and the gas enters the nitrogen making membrane and is separated to obtain nitrogen.

Preferably, the material of the nitrogen-making film comprises any one of poly (4-methyl-1-pentene), brominated polycarbonate, polypropylene, polyimide or polydimethylsiloxane, or a combination of at least two of the same.

Preferably, the nitrogen-producing membrane has an average pore diameter of 0.005 to 0.02 μm, for example, an average pore diameter of 0.005 μm, 0.007 μm, 0.009 μm, 0.011 μm, 0.013 μm, 0.015 μm, 0.017 μm, 0.019 μm, or 0.020 μm.

In a preferred embodiment of the present invention, the electrolytic cell includes a housing, the housing is filled with an electrolyte, and at least one pair of electrodes immersed in the electrolyte is disposed in the housing.

Preferably, the electrolytic cell is externally connected with an air inlet pipeline, and a nitrogen outlet of the nitrogen making device is connected to the electrolytic cell through the air inlet pipeline.

Preferably, a nitrogen flow regulating valve is arranged on the air inlet pipeline.

Preferably, the shell is externally connected with an air outlet pipeline, and the inlet end of the air outlet pipeline is positioned above the liquid level.

Preferably, the electrolytic cell comprises a circulating pipeline, the inlet end of the circulating pipeline is positioned above the liquid level in the shell, the outlet end of the circulating pipeline is connected to an air inlet pipeline, and gas in the electrolytic cell circularly flows through the circulating pipeline.

The invention ensures the nitrogen and the nitric oxide generated by electrolysis to circulate in the electrolytic cell by arranging the circulating pipeline, thereby ensuring the concentration and the high-efficiency output of the nitric oxide.

Preferably, a purging piece is arranged in the electrolytic cell and used for purging the electrode.

The invention uses the purging gas generated by the purging piece to blow away the nitric oxide gas generated on the surface of the electrode by arranging the purging piece, thereby avoiding the generated gas from being accumulated on the surface of the electrode and in the electrolyte.

Preferably, the purge is located below the electrode.

Preferably, the blowing member comprises an open box body, and the box body is filled with air stones.

The invention adopts the air bubble stone, increases the sweeping effect on the surface of the electrode and improves the electrolysis efficiency of the electrolytic cell.

Preferably, the opening direction of the box body faces to the corresponding electrode.

Preferably, the air inlet pipeline and the circulating pipeline are converged into one pipeline and then are respectively connected to the purging piece.

Preferably, a circulation pump is arranged on the circulation pipeline.

Preferably, the electrolytic cell is circularly connected with the gas-liquid separator through a first pipeline and a second pipeline, and the first pipeline extends into the position below the liquid level in the shell; the second pipeline is connected above the liquid level in the shell.

Preferably, the first pipeline and the second pipeline are both connected to a switching valve at the same time, and the switching valve is used for switching the working state and the temporary stop state of the gas-liquid separator; the working state comprises: electrolyte flows through a switching valve through the first pipeline and enters the gas-liquid separator for gas-liquid separation, and the electrolyte flows back into the electrolytic cell through the second pipeline; the critical standstill state includes: and gas in the electrolytic cell flows through the switching valve through the second pipeline, enters the gas-liquid separator, purges residual electrolyte, and flows back into the electrolytic cell through the first pipeline.

The gas-liquid separator changes the running state including the working state and the temporary stopping state through the switching valve, and under the working state, the electrolyte in the electrolytic cell enters the gas-liquid separator, so that the residual nitric oxide in the electrolytic cell is removed, and the repeatability and consistency of the concentration of the nitric oxide generated in the next use are ensured; in the state of approaching to stop, through gaseous anti-blowing, blow remaining electrolyte in the vapour and liquid separator back to the electrolytic bath, avoid electrolyte to gather in the vapour and liquid separator, influence vapour and liquid separator's life.

Preferably, the gas-liquid separator is connected with an air pump, and the air pump injects carrier gas into the gas-liquid separator for bringing the separated gas out of the gas-liquid separator.

Preferably, the first line is provided with a filter, the filter being located between the electrolytic cell and the switching valve.

The invention is provided with the filter to prevent impurities in the electrolyte from entering the gas-liquid separator, damaging membrane components in the gas-liquid separator and influencing the separation effect of the gas-liquid separator.

Preferably, a solenoid valve is arranged on the first pipeline and is positioned between the filter and the switching valve.

According to the invention, the electromagnetic valve is arranged on the first pipeline, and the electromagnetic valve prevents the electrolyte in the electrolytic cell from being sucked back into the gas-liquid separator because the electrolytic cell has certain pressure during operation.

Preferably, a gas-liquid dual-purpose pump is arranged on the first pipeline, and the gas-liquid dual-purpose pump is positioned between the switching valve and the gas-liquid separator.

The gas-liquid dual-purpose pump provided by the invention can pump electrolyte and gas, and meets different functions of electrolyte delivery and gas delivery when the gas-liquid separator is in a working state and a temporary stop state.

Preferably, the area of the separation membrane in the gas-liquid separator is 1000-50000 cm ² For example, an area of 1000cm ² 、5000cm ² 、10000cm ² 、15000cm ² 、20000cm ² 、25000cm ² 、30000cm ² 、35000cm ² 、40000cm ² 、45000cm ² Or 50000cm ² 。

As a preferred technical scheme of the invention, the electrolyte comprises a buffer solution, a nitrogen source and a catalyst, wherein the catalyst comprises a metal-based complex; the central atom of the metal-based complex is a metal-based atom, and the ligand of the metal-based complex is a nitrogen-containing multi-site ligand.

According to the invention, the concentration of NO generated by electrolysis can be effectively improved by adding the metal-based complex catalyst into the electrolyte, and the generated gas does not contain nitrogen dioxide and other byproducts. The relevant reactions are as follows:

m (high valence) (L) + e ^- → M (Low price) (L)

M (Low price) (L) + NO ^- ₂ +e ^- → M (high valence) (L) + NO + H ₂ O

Note: m is one or at least two of copper, iron, titanium, chromium, manganese, cobalt or nickel.

Preferably, the buffer solution comprises one or a combination of at least two of 4-hydroxyethyl piperazine ethanethiosulfonic acid buffer solution, 3-morpholine propanesulfonic acid buffer solution, tris, citrate buffer solution, phosphate buffer solution, boric acid-borax buffer solution or organic buffer solution.

Preferably, the buffer solution has a molar concentration of 0.01 to 3mol/L in the electrolyte, for example, a molar concentration of 0.01mol/L, 0.5mol/L, 1mol/L, 1.5mol/L, 2mol/L, 2.5mol/L or 3 mol/L.

Preferably, the nitrogen source comprises nitrite.

Preferably, the nitrite comprises an inorganic nitrite and/or an organic nitrite.

Preferably, the molar concentration of the nitrogen source in the electrolyte is 0.01-5 mol/L, for example, the molar concentration is 0.01mol/L, 0.5mol/L, 1mol/L, 1.5mol/L, 2mol/L, 2.5mol/L, 3mol/L, 3.5mol/L, 4mol/L, 4.5mol/L or 5 mol/L.

Preferably, the metal-based atoms include one or a combination of at least two of copper, iron, titanium, chromium, manganese, cobalt, or nickel.

Preferably, the nitrogen-containing multi-site ligand comprises one or a combination of at least two of tris (2-pyridylmethyl) amine, 1,4, 7-triazacyclononane, 1,4, 7-trimethyl-1, 4, 7-triazacyclononane, tris (2-aminoethyl) amine, tris (2-dimethylaminoethyl) or bis (2-aminomethylpyridine) -propionic acid.

Preferably, the molar concentration of the catalyst in the electrolyte is 1-15 mmol/L, such as 1mmol/L, 2mmol/L, 3mmol/L, 4mmol/L, 5mmol/L, 6mmol/L, 7mmol/L, 8mmol/L, 9mmol/L, 10mmol/L, 11mmol/L, 12mmol/L, 13mmol/L, 14mmol/L or 15 mmol/L.

Preferably, the electrode plate is a single-component conductive material or a substrate coated with a conductive material.

Preferably, the conductive material comprises one or a combination of at least two of platinum, gold, carbon, glassy carbon, stainless steel, ruthenium iridium alloy or boron-doped diamond.

Preferably, the substrate is SiO ₂ One or a combination of at least two of conductive glass, tin-doped indium oxide, fluorine-doped indium oxide, a conductive plastic substrate, platinum, gold, carbon, glassy carbon, stainless steel, or ruthenium-iridium alloy.

As a preferable technical scheme of the invention, the purification unit comprises a purification membrane component and a clean filter which are connected in sequence along the gas flow direction.

Preferably, the purification membrane module comprises a desalination membrane and a Nafion membrane which are connected in sequence along the gas flow direction.

The invention further removes salt mist and water vapor by arranging the clean filter.

Preferably, the material of the salt fog removing film comprises any one or a combination of at least two of polytetrafluoroethylene, polyvinylidene fluoride, polyether sulfone, mixed cellulose ester, organic nylon 6 or organic nylon 66.

Preferably, the average pore diameter of the salt fog removing film is 0.1-2 μm, for example, the average pore diameter is 0.1 μm, 0.2 μm, 0.4 μm, 0.6 μm, 0.8 μm, 1.0 μm, 1.2 μm, 1.4 μm, 1.6 μm, 1.8 μm or 2.0 μm.

Preferably, said purification unit further comprises NO _x A gas outlet end of the gas-liquid separator is connected with NO _x A purification device.

Preferably, a pressure relief branch pipe is externally connected to a pipeline connecting the clean filter and the breathing simulation device, and the pressure relief branch pipe is connected to the NO _x A purification device.

Preferably, said NO _x The purification device is filled with alumina loaded with potassium permanganate.

Preferably, the potassium permanganate-supporting alumina is spherical in shape.

Preferably, the inhalation pipeline is provided with a concentration sensor and a flow rate sensor, the concentration sensor is used for detecting the concentration of nitric oxide in the inhalation pipeline, and the flow rate sensor is used for detecting the flow rate of nitric oxide in the inhalation pipeline.

Preferably, the ventilator is provided with a monitoring sensor, and the monitoring sensor is used for detecting the tidal volume and the respiratory rate of the ventilator.

Preferably, the system device further comprises a controller, wherein the controller is respectively and independently electrically connected with the concentration sensor, the flow rate sensor, the monitoring sensor, the electrolytic cell and each screw rod lifting piece; the controller respectively receives feedback signals of the concentration sensor, the flow velocity sensor and the monitoring sensor, and feeds back and adjusts electrolysis parameters of the electrolytic cell and the lifting degree of the screw rod lifting piece.

In a second aspect, the present invention provides an output method using the system apparatus for realizing stable output of nitric oxide according to the first aspect, where the output method includes:

nitric oxide generated by electrolytic reaction in the electrolytic cell enters the purification unit, purified nitric oxide enters the breathing simulation device in the output unit, the breathing simulation device adjusts the inflation state and the deflation state in combination with the breathing of a user and releases nitric oxide, and after the electrolytic reaction is finished, the gas-liquid separator removes the residual nitric oxide in the electrolytic cell.

As a preferred technical solution of the present invention, the output method specifically includes:

the method comprises the following steps that (I) compressed gas sequentially enters a water vapor filter and a dust filter, water vapor and dust are removed respectively, then the compressed gas enters a nitrogen making device for separation, and nitrogen is obtained after separation; nitrogen is introduced into the electrolyte through the air inlet pipeline, gas on the electrode is swept, an electrolytic reaction is carried out to generate nitric oxide, the nitrogen and the nitric oxide in the electrolytic cell are sprayed out through the sweeping piece together with the air inlet through the circulating pipeline, the gas generated on the electrode is blown away, the nitric oxide sequentially enters the desalination mist removal membrane, the Nafion membrane and the clean filter after the concentration of the nitric oxide meets the requirement, the purified nitric oxide enters the respiration simulation device, and the respiration simulation component is in an inflated state when a user exhales; when a user inhales, at least one respiration simulation component is in a deflation state, so that the respiration simulation is realized, and nitric oxide is released;

(II) a concentration sensor and a flow rate sensor respectively detect the concentration and the flow rate of nitric oxide in the respiratory tract, and a detection sensor detects the tidal volume and the respiratory rate of the respirator; the controller calculates the capacity of the air bag and the flow rate of the nitric oxide according to the flow rate of the nitric oxide, the tidal volume of the breathing machine and the breathing ratio of the breathing machine, and feeds back and controls the lifting degree of the screw rod lifting piece; the controller controls the voltage and the current of the electrolytic cell according to the concentration feedback of the nitric oxide, and when the concentration of the nitric oxide needs to be increased, the controller controls the voltage and the current of the electrolytic cell to be increased;

(III) after the release of nitric oxide is stopped, the gas-liquid separator enters a working state, the electrolyte flows through the switching valve through the first pipeline and enters the gas-liquid separator for gas-liquid separation, the electrolyte flows back into the electrolytic cell through the second pipeline, and the carrier gas discharges the gas separated by the gas-liquid separator to NO _x The purification device is used for refluxing the electrolyte into the electrolytic cell; after the working state is finished, the switching valve is switched, the gas-liquid separator enters the temporary stop state, gas in the electrolytic cell flows through the switching valve through the second pipeline, enters the gas-liquid separator, purges residual electrolyte, and the electrolyte flows back into the electrolytic cell through the first pipeline;

and (IV) when the electrolytic cell fails, starting a standby device, and inputting nitric oxide into the breathing machine through the gas cylinder.

In a preferred embodiment of the present invention, in step (i), the volume concentration of nitrogen is 99.0% or more, for example, the volume concentration of nitrogen is 99.00%, 99.10%, 99.20%, 99.30%, 99.40%, 99.50%, 99.60%, 99.70%, 99.80%, 99.90%, or 99.990%.

Preferably, the nitrogen gas has a flow rate of 50 to 600mL/min, for example, a flow rate of 50mL/min, 100mL/min, 150mL/min, 200mL/min, 250mL/min, 300mL/min, 350mL/min, 400mL/min, 450mL/min, 500mL/min, 550mL/min or 600 mL/min.

Preferably, the flow rate of the gas in the circulating pipeline is 0.5-3L/min, for example, 0.5L/min, 1L/min, 1.5L/min, 2L/min, 2.5L/min or 3L/min.

Preferably, the deflation states of the respiration simulation components alternate;

preferably, the method of the electrolytic reaction comprises: and applying an excitation current or an excitation voltage higher than a set value to the electrode, and adjusting to the set current or the set voltage after a period of time, wherein NO is stably output in a short time.

In the electrolysis method provided by the present invention, the stage of applying the excitation current and the stage of applying the set current may both use unidirectional current or both use bidirectional current, but it is understood that one stage may use unidirectional current and the other stage uses bidirectional current.

According to the invention, the excitation current of large current is applied firstly, then the set current is applied, the concentration of NO generated by electrolysis is in direct proportion to the applied current or voltage, the larger excitation current or voltage is applied for a short time, the time for the concentration to reach a stable value is greatly shortened, and the application scene of the device is expanded. Meanwhile, the electrolysis method provided by the invention is matched with the electrolyte with special composition, so that high-concentration and rapid and stable output of NO is realized, NO by-products such as nitrogen dioxide are generated, and particularly, the electrolyte prepared by adopting a special catalyst realizes high-concentration output of NO, NO by-products are generated, and rapid and stable output of NO is realized.

Preferably, the excitation current or the excitation voltage is 2 to 8 times of the set value, for example, 2 times, 3 times, 4 times, 5 times, 6 times, 7 times or 8 times.

Preferably, the excitation current or the excitation voltage acts for 0.5-3 min, for example, 0.5min, 1min, 1.5min, 2min, 2.5min or 3 min.

Preferably, the set current is 0 to 300mA, and does not include 0, and may be, for example, 10mA, 50mA, 100mA, 150mA, 200mA, 250mA or 300 mA.

Preferably, the set voltage is 1.4-3.0V, such as 1.4V, 1.5V, 1.6V, 1.7V, 1.8V, 1.9V, 2.0V, 2.1V, 2.2V, 2.3V, 2.4V, 2.5V, 2.6V, 2.7V, 2.8V, 2.9V or 3.0V.

Preferably, the NO is stably output within 2-10 min, for example, 2min, 3min, 4min, 5min, 6min, 7min, 8min, 9min or 10 min.

Preferably, in step (III), the working state is performed for a time of 20min or less, for example, for a time of 1min, 2min, 4min, 6min, 8min, 10min, 12min, 14min, 16min, 18min or 20 min.

Preferably, in step (iii), the carrier gas is air.

Preferably, in step (III), the time of the temporary stop state is 0.5-2 min, for example, 0.5min, 0.6min, 0.7min, 0.8min, 0.9min, 1.0min, 1.1min, 1.2min, 1.3min, 1.4min, 1.5min, 1.6min, 1.7min, 1.8min, 1.9min or 2.0 min.

The recitation of numerical ranges herein includes not only the above-recited numerical values, but also any numerical values between non-recited numerical ranges, and is not intended to be exhaustive or to limit the invention to the precise numerical values encompassed within the range for brevity and clarity.

Compared with the prior art, the invention has the beneficial effects that:

Drawings

Fig. 1 is a schematic structural diagram of a system device for realizing stable output of nitric oxide according to an embodiment of the present invention.

Wherein, 1-a water vapor filter; 2-a dust filter; 3-a nitrogen making device; 4-an air inlet pipeline; 5-an electrolytic cell;6-an electrode; 7-purging; 8-a circulation line; 9-a circulating pump; 10-an air pump; 11-a gas-liquid separator; 12-gas-liquid dual-purpose pump; 13-a switching valve; 14-a filter; 15-a first conduit; 16-a second conduit; 17-desalting fog film; 18-Nafion membrane; 19-cleaning the filter; 20-pressure relief branch pipe; 21-two-position three-way switching valve; 22-air bag; 23-a screw lifting piece; 24-NO ₂ A conversion filter element device; 25-NO _x A purification device.

Detailed Description

It is to be understood that in the description of the present invention, the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be taken as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.

It should be noted that, unless explicitly stated or limited otherwise, the terms "disposed," "connected" and "connected" in the description of the present invention are to be construed broadly and may include, for example, a fixed connection, a detachable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.

The technical solution of the present invention is further explained by the following embodiments.

In one embodiment, the present invention provides a system device for realizing stable output of nitric oxide, as shown in fig. 1, the system device comprises a generating unit, a purifying unit and an output unit, wherein the generating unit comprises an electrolytic cell 5 and a gas-liquid separator 11 which are circularly connected; the output unit comprises a breathing simulation device; the nitric oxide generated by the electrolytic cell 5 enters the purification unit, enters the breathing simulation device in the output unit after purification and is released, and after the electrolytic cell 5 stops generating the nitric oxide, the gas-liquid separator 11 removes the residual nitric oxide in the electrolytic cell 5.

According to the invention, NO remained in the electrolytic cell 5 after electrolysis is removed through the gas-liquid separator 11 circularly connected with the electrolytic cell 5, so that the harm of the residual NO to the electrolyte and the electrode 6 is avoided, the electrolyte and the electrode 6 can be used repeatedly, and the stable and efficient output of nitric oxide is realized; in addition, the output nitric oxide is regulated through the breathing simulation device, the output stability of the nitric oxide is ensured, and the device has the characteristics of high nitric oxide gas generation rate, stable output concentration and the like.

Further, the breathing simulation device comprises at least two breathing simulation components working alternately. The breathing simulation assembly comprises a screw rod pulling piece 23 and an air bag 22, wherein the screw rod pulling piece 23 is used for pressing and pulling the air bag 22. Furthermore, the airbag 22 is connected with a two-position three-way switching valve 21, the airbag 22 is connected to a working port of the two-position three-way switching valve 21, an air outlet end of the purification unit is respectively and independently connected to an inflation port of the two-position three-way switching valve 21, and the airbag 22 is provided with a pressure sensor for detecting the pressure in the airbag 22. In the respiration simulation assembly, the air bag 22 is pressed and pulled through the screw rod pulling piece 23, the respiration process is simulated, the pressing degree of the screw rod pulling piece 23 on the air bag 22 is adjusted, and the output stability of nitric oxide gas is further improved by matching with the respiration of a user.

Further, the output unit further includes NO ₂ The gas outlets of the two-position three-way switching valve 21 in the conversion filter element device 24 and the breath simulation device are converged into one path to be connected with NO ₂ A conversion filter element device 24, a screw rod lifting piece 23 lifting airThe air outlet of the two-position three-way switching valve 21 is closed, the inflation inlet is opened, and air enters the air bag 22; the air bag 22 is pressed by the screw rod pulling piece 23, the air outlet of the two-position three-way switching valve 21 is opened, the inflation inlet is closed, and the gas is discharged out of the air bag 22 and passes through NO ₂ The conversion cartridge assembly 24 is discharged; the bladder 22 is provided with a pressure sensor for detecting the pressure inside the bladder 22.

Further, the output unit further includes NO ₂ The gas outlets of the two-position three-way switching valve 21 in the conversion filter element device 24 and the breath simulation device are converged into one path to be connected with NO ₂ The conversion filter element device 24 is characterized in that a screw rod pulling piece 23 pulls the air bag 22, and gas enters the air bag 22 through a switching valve 13; the screw lifter 23 presses the airbag 22, and the gas is discharged out of the airbag 22 through the switching valve 13, and passes through NO ₂ The conversion cartridge assembly 24 is discharged.

Further, NO ₂ The conversion cartridge assembly 24 includes a cartridge body; the cylinder is internally divided into at least two baffling cavities which axially penetrate through the cylinder and are filled with NO ₂ One end of each of two adjacent baffling cavities is communicated with each other, and gas enters the cylinder body and flows through the baffling cavities in sequence in a serpentine baffling mode.

Further, NO ₂ The conversion filter element material comprises a carrier and reducing vitamins coated on the surface of the carrier. Still further, the carrier comprises one or a combination of at least two of silica gel, molecular sieve, alumina, sponge, cotton, or a foamed resin. The reducing vitamin comprises one or more of vitamin C, vitamin E or vitamin A. Every 100g of the carrier is coated with 5-50 g of reducing vitamins.

Further, NO ₂ The air outlet end of the conversion filter element device 24 is connected with a breathing machine through a breathing pipeline, and the breathing pipeline is divided into an independent incoming pipeline and an independent outgoing pipeline which are connected with the breathing machine. Furthermore, a standby device is connected to the incoming pipeline externally and comprises a gas cylinder, the gas cylinder is connected to the incoming pipeline through a standby branch, and a pressure reducing valve and a flow meter are sequentially arranged on the standby branch along the gas flow direction. The invention is connected with the standby device, when the system device breaks down suddenly, the standby device is started, and the device is prevented from being absentThe method has the advantages of continuous working, low cost, simple operation, rapid gas outlet and the like.

Further, the system device also comprises a nitrogen production unit, and the nitrogen production unit comprises a filtering device and a nitrogen production device 3 which are sequentially connected along the gas flow direction. The filtering device comprises a water vapor filter 1 and a dust filter 2 which are connected in sequence along the gas flow direction. The nitrogen making device 3 comprises a nitrogen making film, and the gas enters the nitrogen making film and is separated to obtain nitrogen. Furthermore, the nitrogen-producing film is made of one or a combination of at least two of poly (4-methyl-1-pentene), brominated polycarbonate, polypropylene, polyimide and polydimethylsiloxane, and has an average pore diameter of 0.005 to 0.02 μm.

Further, the electrolytic cell 5 comprises a casing in which the electrolyte is injected, inside which there is arranged at least one pair of electrodes 6 immersed in the electrolyte. The electrolytic cell 5 is externally connected with an air inlet pipeline 4, and a nitrogen outlet of the nitrogen making device 3 is connected with the electrolytic cell 5 through the air inlet pipeline 4. The inlet line 4 is provided with a nitrogen flow rate regulating valve. The shell is externally connected with an air outlet pipeline, and the inlet end of the air outlet pipeline is positioned above the liquid level.

Further, the electrolytic cell 5 comprises a circulating pipeline 8, the inlet end of the circulating pipeline 8 is positioned above the liquid level in the shell, the outlet end of the circulating pipeline 8 is connected to the air inlet pipeline 4, and the gas in the electrolytic cell 5 circularly flows through the circulating pipeline 8.

Further, be provided with in the electrolytic cell 5 and sweep 7, sweep 7 and be used for sweeping electrode 6, sweep 7 and be located the below of electrode 6, sweep 7 and include open box, fill in the box and have the bubble stone, the open direction orientation of box is corresponding electrode 6.

Furthermore, the air inlet pipeline 4 and the circulating pipeline 8 are connected to the purging part 7 respectively after being converged into one pipeline. The circulation pipeline 8 is provided with a circulation pump 9. The electrolytic cell 5 is circularly connected with the gas-liquid separator 11 through a first pipeline 15 and a second pipeline 16, and the first pipeline 15 extends into the shell below the liquid level; the second line 16 opens above the liquid level in the housing. The first pipeline 15 and the second pipeline 16 are both connected to the switching valve 13 at the same time, and the switching valve 13 is used for switching the working state and the temporary stop state of the gas-liquid separator 11; the working state comprises the following steps: the electrolyte flows through the switching valve 13 through the first pipeline 15, enters the gas-liquid separator 11 for gas-liquid separation, and flows back into the electrolytic cell 5 through the second pipeline 16; the critical stop state comprises: the gas in the electrolytic cell 5 flows through the switching valve 13 via the second line 16, enters the gas-liquid separator 11, purges the remaining electrolyte, and the electrolyte flows back into the electrolytic cell 5 via the first line 15.

Further, the gas-liquid separator 11 is connected with an air pump 10, and the air pump 10 injects carrier gas into the gas-liquid separator 11 for carrying the separated gas out of the gas-liquid separator 11.

Further, the first piping 15 is provided with a filter 14, and the filter 14 is located between the electrolytic cell 5 and the switching valve 13. A solenoid valve is provided on the first line 15, the solenoid valve being located between the filter 14 and the switching valve 13.

Further, a gas-liquid dual-purpose pump 12 is arranged on the first pipeline 15, the gas-liquid dual-purpose pump 12 is positioned between the switching valve 13 and the gas-liquid separator 11, and furthermore, the area of a separation membrane in the gas-liquid separator 11 is 1000-50000 cm ² 。

Further, the electrolyte comprises a buffer, a nitrogen source and a catalyst, wherein the catalyst comprises a metal-based complex; the central atom of the metal-based complex is a metal-based atom, and the ligand of the metal-based complex is a nitrogen-containing multi-site ligand.

Further, the buffer solution comprises one or the combination of at least two of 4-hydroxyethyl piperazine ethanesulforic acid buffer solution, 3-morpholine propanesulfonic acid buffer solution, tris (hydroxymethyl) aminomethane, citrate buffer solution, phosphate buffer solution, boric acid-borax buffer solution or organic buffer solution. Furthermore, the molar concentration of the buffer solution in the electrolyte is 0.01-3 mol/L. The nitrogen source includes nitrite. The nitrite comprises inorganic nitrite and/or organic nitrite. The molar concentration of the nitrogen source in the electrolyte is 0.01-5 mol/L. The metal-based atoms include one or a combination of at least two of copper, iron, titanium, chromium, manganese, cobalt, or nickel. The nitrogen-containing multi-site ligand comprises one or a combination of at least two of tri (2-pyridylmethyl) amine, 1,4, 7-triazacyclononane, 1,4, 7-trimethyl-1, 4, 7-triazacyclononane, tri (2-aminoethyl) amine, tri (2-dimethylaminoethyl) or di (2-aminomethylpyridine) -propionic acid. The molar concentration of the catalyst in the electrolyte is 1-15 mmol/L.

Further, the electrode 6 plate is a single-composition conductive material or a substrate coated with a conductive material. Still further, the conductive material includes one or a combination of at least two of platinum, gold, carbon, glassy carbon, stainless steel, ruthenium iridium alloy, or boron doped diamond. The substrate is SiO ₂ One or a combination of at least two of conductive glass, tin-doped indium oxide, fluorine-doped indium oxide, a conductive plastic substrate, platinum, gold, carbon, glassy carbon, stainless steel, or ruthenium-iridium alloy.

Further, the purification unit includes a purification membrane module and a clean filter 19 connected in series in the gas flow direction. The purification membrane component comprises a desalination membrane 17 and a Nafion membrane 18 which are connected in sequence along the gas flow direction.

Further, the material of the defogging film 17 includes any one or a combination of at least two of polytetrafluoroethylene, polyvinylidene fluoride, polyether sulfone, mixed cellulose ester, organic nylon 6, and organic nylon 66. The average pore diameter of the desalting mist film 17 is 0.1 to 2 μm.

Further, the purification unit further comprises NO _x A purification device 25, a gas outlet end of the gas-liquid separator 11 is connected with NO _x Purification device 25, NO _x The purification device 25 is filled with spherical alumina loaded with potassium permanganate. The pipeline connecting the clean filter 19 and the breathing simulation device is externally connected with a pressure relief branch pipe 20, and the NO is connected to the pressure relief branch pipe 20 _x A purification device 25.

Further, a concentration sensor and a flow rate sensor are arranged on the inhalation pipeline, the concentration sensor is used for detecting the concentration of the nitric oxide in the inhalation pipeline, and the flow rate sensor is used for detecting the flow rate of the nitric oxide in the inhalation pipeline. The breathing machine is provided with a monitoring sensor, and the monitoring sensor is used for detecting the tidal volume and the breathing ratio of the breathing machine.

Furthermore, the system device also comprises a controller which is respectively and independently electrically connected with the concentration sensor, the flow velocity sensor, the monitoring sensor, the electrolytic cell 5 and each screw rod lifting piece 23; the controller respectively receives feedback signals of the concentration sensor, the flow velocity sensor and the monitoring sensor, and feeds back and adjusts the electrolysis parameters of the electrolytic cell 5 and the lifting degree of the screw rod lifting piece 23.

In another embodiment, the present invention provides an output method of the system apparatus for realizing stable output of nitric oxide, where the output method specifically includes:

the compressed gas sequentially enters a water vapor filter 1 and a dust filter 2, water vapor and dust are respectively removed, then the compressed gas enters a nitrogen making device 3 for separation, and nitrogen with the volume concentration of more than or equal to 99.0% is obtained after the separation; nitrogen is introduced into the electrolyte through the air inlet pipeline 4, the flow of the nitrogen is 50-600 mL/min, the gas on the purging electrode 6 is purged, an electrolytic reaction is generated to generate nitric oxide, the nitrogen and the nitric oxide in the electrolytic cell 5 are sprayed out through the purging piece 7 through the circulating pipeline 8 and the air inlet, the flow of the gas in the circulating pipeline 8 is 0.5-3L/min, the gas generated on the electrode 6 is blown away, after the concentration of the nitric oxide meets the requirement, the nitric oxide sequentially enters the desalination mist removal membrane 17, the Nafion membrane 18 and the cleaning filter 19, the purified nitric oxide enters the respiration simulation device, and when a user exhales, the respiration simulation component is in an inflated state; when a user inhales, at least one respiration simulation component is in an air release state, and further the air release states of the respiration simulation components are alternately carried out, so that the respiration action is simulated and nitric oxide is released;

(II) a concentration sensor and a flow rate sensor respectively detect the concentration and the flow rate of nitric oxide in the respiratory tract, and a detection sensor detects the tidal volume and the respiratory rate of the respirator; the controller calculates the volume of the air bag 22 and the flow rate of the nitric oxide according to the flow rate of the nitric oxide, the tidal volume of the breathing machine and the breathing ratio of the breathing machine, and feeds back and controls the lifting degree of the screw rod lifting piece 23; the controller controls the voltage and the current of the electrolytic cell 5 according to the concentration of the nitric oxide, and when the concentration of the nitric oxide needs to be increased, the controller controls the voltage and the current of the electrolytic cell 5 to be increased;

(III) after the release of the nitric oxide is stopped, the gas-liquid separator 11 enters a working state, the electrolyte flows through the switching valve 13 through the first pipeline 15 and enters the gas-liquid separator 11 for gas-liquid separation, the electrolyte flows back into the electrolytic cell 5 through the second pipeline 16, and the carrier gas separates the gas from the liquidThe gas separated in the vessel 11 is discharged to NO _x The purifying device 25, optionally, the carrier gas is air, the electrolyte flows back into the electrolytic cell 5, and the time of the working state is less than or equal to 20 min; after the working state is finished, the switching valve 13 is switched, the gas-liquid separator 11 enters a temporary stop state, gas in the electrolytic cell 5 flows through the switching valve 13 through the second pipeline 16, enters the gas-liquid separator 11, residual electrolyte is swept, the electrolyte flows back into the electrolytic cell 5 through the first pipeline 15, and the time of the temporary stop state is 0.5-2 min;

(IV) when the electrolytic cell 5 fails, the standby device inputs nitric oxide into the breathing machine through the gas cylinder.

In step (I), the method for electrolytic reaction comprises: and applying an excitation current or an excitation voltage which is 2-8 times of the set value to the electrode 6, and after the duration of 0.5-3 min, adjusting to the set current or the set voltage, wherein the set current is 0-300 mA, the set voltage is 1.4-3.0V, and NO is stably output within 2-10 min.

Example 1

The present embodiment provides a system device for realizing stable output of nitric oxide, and the system device for realizing stable output of nitric oxide is based on an embodiment, wherein the breathing simulation device includes two breathing simulation components.

The nitrogen making film is made of poly (4-methyl-1-pentene), and the average pore diameter of the nitrogen making film is 0.01 mu m; the area of the separation membrane in the gas-liquid separator 11 was 25000cm ² (ii) a The buffer solution is 4-hydroxyethyl piperazine ethanethiosulfonic acid buffer solution, and the molar concentration of the buffer solution in the electrolyte is 0.01 mol/L. The nitrogen source is sodium nitrite, and the molar concentration in the electrolyte is 0.01 mol/L. The catalyst is a metal-based complex, the central atom of the metal-based complex is a copper-based atom, the ligand of the metal-based complex is tri (2-pyridylmethyl) amine, and the molar concentration of the catalyst in the electrolyte is 1 mmol/L. The electrode 6 is made of platinum.

The desalting mist film 17 is made of polytetrafluoroethylene and has an average pore diameter of 1 μm. NO ₂ In the material of the conversion filter element, the carrier is alumina, the reducing vitamin is vitamin C, and each 100g of the carrier is coated with 25g of the reducing vitamin.

The present embodiment further provides an output method of the system apparatus for realizing stable output of nitric oxide, where the output method specifically includes:

compressed gas sequentially enters a water vapor filter 1 and a dust filter 2, water vapor and dust are respectively removed, then the compressed gas enters a nitrogen making device 3 for separation, and nitrogen with the volume concentration of 99.0% is obtained after the separation; nitrogen is introduced into the electrolyte through the air inlet pipeline 4, the flow of the nitrogen is 50mL/min, the gas on the purging electrode 6 is purged, an electrolytic reaction is carried out to generate nitric oxide, the nitrogen and the nitric oxide in the electrolytic cell 5 are sprayed out through the purging piece 7 together with the air inlet through the circulating pipeline 8, the flow of the gas in the circulating pipeline 8 is 0.5L/min, the gas generated on the electrode 6 is blown away, the nitric oxide sequentially enters the desalination mist removal membrane 17, the Nafion membrane 18 and the cleaning filter 19 after the concentration of the nitric oxide meets the requirement, the purified nitric oxide enters the respiration simulation device, and when a user exhales, the two respiration simulation components are in an inflated state; when a user inhales, one breathing simulation component is in a deflation state, the other breathing simulation component is still in an inflation state, the simulated breathing action is realized, nitric oxide is released, and the concentration of released NO is 200 ppm;

(III) after the release of nitric oxide is stopped, the gas-liquid separator 11 enters a working state, the electrolyte flows through the switching valve 13 through the first pipeline 15 and enters the gas-liquid separator 11 for gas-liquid separation, the electrolyte flows back into the electrolytic cell 5 through the second pipeline 16, and the air carrier gas discharges the gas separated by the gas-liquid separator 11 to NO _x The purification device 25 is used for refluxing the electrolyte into the electrolytic cell 5, and the working state time is 10 min; operating state knotAfter that, the switching valve 13 is switched, the gas-liquid separator 11 enters a temporary stop state, gas in the electrolytic cell 5 flows through the switching valve 13 through the second pipeline 16, enters the gas-liquid separator 11 to purge residual electrolyte, the electrolyte flows back into the electrolytic cell 5 through the first pipeline 15, and the temporary stop state lasts for 1 min;

In step (i), the method of the electrolytic reaction comprises: and applying an excitation current 2 times of the set value to the electrode 6, adjusting to the set current after the excitation current lasts for 0.5min, wherein the set current is 10mA, and NO is stably output within 10 min.

Example 2

The nitrogen making film is made of brominated polycarbonate, and the average pore diameter of the nitrogen making film is 0.02 mu m; the area of the separation membrane in the gas-liquid separator 11 was 1000cm ² . The buffer solution is 3-morpholine propanesulfonic acid buffer solution, and the molar concentration of the buffer solution in the electrolyte is 1 mol/L. The nitrogen source is sodium nitrite, and the molar concentration of the sodium nitrite in the electrolyte is 1 mol/L. The catalyst is a metal-based complex, the central atom of the metal-based complex is an iron-based atom, the ligand of the metal-based complex is 1,4, 7-triazacyclononane, and the molar concentration of the catalyst in the electrolyte is 3 mmol/L. The electrode 6 is made of gold.

The material of the desalting fog film 17 is polyvinylidene fluoride, and the average pore diameter is 0.1 μm. NO ₂ In the material of the conversion filter element, the carrier is cotton, the reducing vitamin is vitamin A, and 5g of the reducing vitamin is coated on every 100g of the carrier.

The embodiment further provides an output method of the system device for realizing stable output of nitric oxide, where the output method specifically includes:

compressed gas sequentially enters a water vapor filter 1 and a dust filter 2, water vapor and dust are respectively removed, then the compressed gas enters a nitrogen making device 3 for separation, and nitrogen with the volume concentration of 99.6% is obtained after the separation; nitrogen is introduced into the electrolyte through the air inlet pipeline 4, the flow of the nitrogen is 100mL/min, the gas on the electrode 6 is swept, an electrolytic reaction is carried out to generate nitric oxide, the nitrogen and the nitric oxide in the electrolytic cell 5 are sprayed out through the sweeping part 7 together with the air inlet through the circulating pipeline 8, the flow of the gas in the circulating pipeline 8 is 1L/min, the gas generated on the electrode 6 is blown away, the nitric oxide sequentially enters the desalination mist removal membrane 17, the Nafion membrane 18 and the cleaning filter 19 after the concentration of the nitric oxide meets the requirement, the purified nitric oxide enters the respiration simulation device, and when a user exhales, the two respiration simulation components are in an inflated state; when a user inhales, one respiration simulation component is in a deflation state, the other respiration simulation component is still in an inflation state, the simulation of respiration action is realized, nitric oxide is released, and the concentration of released NO is 1200 ppm;

(III) after the release of nitric oxide is stopped, the gas-liquid separator 11 enters a working state, the electrolyte flows through the switching valve 13 through the first pipeline 15 and enters the gas-liquid separator 11 for gas-liquid separation, the electrolyte flows back into the electrolytic cell 5 through the second pipeline 16, and the air carrier gas discharges the gas separated by the gas-liquid separator 11 to NO _x The purification device 25 is used for refluxing the electrolyte into the electrolytic cell 5, and the working state time is 5 min; after the working state is finished, the switching valve 13 is switched, the gas-liquid separator 11 enters the temporary stopping state, gas in the electrolytic cell 5 flows through the switching valve 13 through the second pipeline 16, enters the gas-liquid separator 11 to purge residual electrolyte, the electrolyte flows back into the electrolytic cell 5 through the first pipeline 15, and the temporary stopping state lasts for 0.5 min;

In step (I), the method of electrolytic reaction comprises: and applying an excitation voltage which is 3 times of the set value to the electrode 6, adjusting to the set voltage after lasting for 1min, wherein the set voltage is 1.4V, and NO is stably output within 9 min.

Example 3

The present embodiment provides a system device for realizing stable output of nitric oxide, and the system device for realizing stable output of nitric oxide is based on an embodiment, wherein the breathing simulation device includes three breathing simulation components.

The nitrogen making membrane is made of polypropylene, and the average pore diameter of the nitrogen making membrane is 0.012 mu m; the area of the separation membrane in the gas-liquid separator 1111 is 50000cm ² . The buffer solution is tris (hydroxymethyl) aminomethane, and the molar concentration of the buffer solution in the electrolyte solution is 1.5 mol/L. The nitrogen source is potassium nitrite, and the molar concentration of the potassium nitrite in the electrolyte is 2 mol/L. The catalyst is a metal-based complex, the central atom of the metal-based complex is a titanium-based atom, the ligand of the metal-based complex is 1,4, 7-trimethyl-1, 4, 7-triazacyclononane, the molar concentration of the catalyst in the electrolyte is 4mmol/L, and the material of the electrode 6 is carbon.

The desalting fog membrane 17 is made of polyether sulfone and has an average pore diameter of 2 μm. NO ₂ In the material of the conversion filter element, the carrier is foaming resin, the reducing vitamin is vitamin E, and each 100g of the carrier is coated with 50g of the reducing vitamin.

compressed gas sequentially enters a water vapor filter 1 and a dust filter 2, water vapor and dust are respectively removed, then the compressed gas enters a nitrogen making device 3 for separation, and nitrogen with the volume concentration of 99.7% is obtained after the separation; nitrogen is introduced into the electrolyte through the air inlet pipeline 4, the flow of the nitrogen is 200mL/min, the gas on the purging electrode 6 is purged, an electrolytic reaction is carried out to generate nitric oxide, the nitrogen and the nitric oxide in the electrolytic cell 5 are sprayed out through the purging piece 7 together with the air inlet through the circulating pipeline 8, the flow of the gas in the circulating pipeline 8 is 1.5L/min, the gas generated on the electrode 6 is blown away, the nitric oxide sequentially enters the desalination mist removal membrane 17, the Nafion membrane 18 and the cleaning filter 19 after the concentration of the nitric oxide meets the requirement, the purified nitric oxide enters the respiration simulation device, and when a user exhales, the three respiration simulation components are all in an inflated state; when a user inhales, one of the breathing simulation components is in a deflation state, the other two breathing simulation components are still in an inflation state, and the deflation states of the three breathing simulation components are alternately performed, so that the simulated breathing action is realized, nitric oxide is released, and the concentration of released NO is 3000 ppm;

(III) after the release of nitric oxide is stopped, the gas-liquid separator 11 enters a working state, the electrolyte flows through the switching valve 13 through the first pipeline 15 and enters the gas-liquid separator 11 for gas-liquid separation, the electrolyte flows back into the electrolytic cell 5 through the second pipeline 16, and the air carrier gas discharges the gas separated by the gas-liquid separator 11 to NO _x The purification device 25 is used for refluxing the electrolyte into the electrolytic cell 5, and the working state time is 12 min; after the working state is finished, the switching valve 13 is switched, the gas-liquid separator 11 enters a temporary stop state, gas in the electrolytic cell 5 flows through the switching valve 13 through the second pipeline 16, enters the gas-liquid separator 11 to purge residual electrolyte, the electrolyte flows back into the electrolytic cell 5 through the first pipeline 15, and the temporary stop state lasts for 0.9 min;

In step (I), the method of electrolytic reaction comprises: and applying an excitation current which is 5 times of the set value to the electrode 6, adjusting to the set current after lasting for 1.5min, wherein the set current is 100mA, and NO is stably output within 6 min.

Example 4

The nitrogen making film is made of polyimide, and the average pore diameter of the nitrogen making film is 0.005 mu m; the area of the separation membrane in the gas-liquid separator 11 is 37500cm ² . The buffer solution comprises a citrate buffer solution, and the molar concentration of the buffer solution in the electrolyte is 2 mol/L. The nitrogen source is sodium nitrite, and the molar concentration of the sodium nitrite in the electrolyte is 3 mol/L. The catalyst is a metal-based complex, the central atom of the metal-based complex is a chromium-based atom, the ligand of the metal-based complex is tri (2-aminoethyl) amine, and the molar concentration of the catalyst in the electrolyte is 5 mmol/L. The electrodes 6 are all made of SiO coated with glassy carbon coating ₂ 。

The salt mist removing film 17 is made of organic nylon 6 and has an average pore diameter of 0.1 μm. NO ₂ In the material of the conversion filter element, the carrier is a molecular sieve, the reducing vitamin is vitamin C, and each 100g of the carrier is coated with 30g of the reducing vitamin.

compressed gas sequentially enters a water vapor filter 1 and a dust filter 2, water vapor and dust are respectively removed, then the compressed gas enters a nitrogen making device 3 for separation, and nitrogen with the volume concentration of 99.990% is obtained after the separation; nitrogen is introduced into the electrolyte through the air inlet pipeline 4, the flow of the nitrogen is 300mL/min, the gas on the sweeping electrode 6 is blown out, an electrolytic reaction is generated to generate nitric oxide, the nitrogen and the nitric oxide in the electrolytic cell 5 are sprayed out through the sweeping part 7 together with the air inlet through the circulating pipeline 8, the flow of the gas in the circulating pipeline 8 is 2L/min, the gas generated on the electrode 6 is blown away, the nitric oxide sequentially enters the desalination mist removal membrane 17, the Nafion membrane 18 and the cleaning filter 19 after the concentration of the nitric oxide meets the requirement, the purified nitric oxide enters the respiration simulation device, and when a user exhales, the three respiration simulation components are all in an inflated state; when a user inhales, one of the breathing simulation assemblies is in a deflation state, the other two breathing simulation assemblies are still in an inflation state, and the deflation states of the three breathing simulation assemblies are alternately performed, so that the simulated breathing action is realized, nitric oxide is released, and the concentration of released NO is 4200 ppm;

(II) a concentration sensor and a flow rate sensor respectively detect the concentration and the flow rate of nitric oxide in the inhalation pipeline, and a detection sensor detects the tidal volume and the respiratory rate of the respirator; the controller calculates the volume of the air bag 22 and the flow rate of the nitric oxide according to the flow rate of the nitric oxide, the tidal volume of the breathing machine and the breathing ratio of the breathing machine, and feeds back and controls the lifting degree of the screw rod lifting piece 23; the controller controls the voltage and the current of the electrolytic cell 5 according to the concentration of the nitric oxide, and when the concentration of the nitric oxide needs to be increased, the controller controls the voltage and the current of the electrolytic cell 5 to be increased;

(III) after the release of nitric oxide is stopped, the gas-liquid separator 11 enters a working state, the electrolyte flows through the switching valve 13 through the first pipeline 15 and enters the gas-liquid separator 11 for gas-liquid separation, the electrolyte flows back into the electrolytic cell 5 through the second pipeline 16, and the air carrier gas discharges the gas separated by the gas-liquid separator 11 to NO _x The purification device 25 is used for refluxing the electrolyte into the electrolytic cell 5, and the working state time is 5 min; after the working state is finished, the switching valve 13 is switched, the gas-liquid separator 11 enters the temporary stopping state, gas in the electrolytic cell 5 flows through the switching valve 13 through the second pipeline 16, enters the gas-liquid separator 11 to purge residual electrolyte, the electrolyte flows back into the electrolytic cell 5 through the first pipeline 15, and the temporary stopping state lasts for 1.5 min;

In step (I), the method of electrolytic reaction comprises: and applying an excitation voltage 6 times of the set value to the electrode 6, adjusting to the set voltage after lasting for 2min, wherein the set voltage is 2V, and NO is stably output within 5 min.

Example 5

The material of the nitrogen making film is polydimethylsiloxane, and the average aperture of the nitrogen making film is 0.008 mu m; the area of the separation membrane in the gas-liquid separator 11 was 12500cm ² . The buffer solution comprises phosphate buffer solution, and the molar concentration of the buffer solution in the electrolyte is 2.5 mol/L. The nitrogen source is sodium nitrite, and the molar concentration of the sodium nitrite in the electrolyte is 4 mol/L. The catalyst is a metal-based complex, the central atom of the metal-based complex is a manganese-based atom, the ligand of the metal-based complex is tris (2-dimethylaminoethyl), and the molar concentration of the catalyst in the electrolyte is 6 mmol/L. The electrodes 66 are all conductive glass coated with a stainless steel layer.

The material of the demisting membrane 17 is organic nylon 66, and the average pore diameter is 0.8 μm. NO ₂ The carrier in the material of the conversion filter element is sponge, the reducing vitamin is vitamin A, and 20g of the reducing vitamin is coated on every 100g of the carrier.

compressed gas sequentially enters a water vapor filter 1 and a dust filter 2, water vapor and dust are respectively removed, then the compressed gas enters a nitrogen making device 3 for separation, and nitrogen with the volume concentration of 99.8% is obtained after the separation; nitrogen is introduced into the electrolyte through the air inlet pipeline 4, the flow of the nitrogen is 400mL/min, the gas on the purging electrode 6 is purged, an electrolytic reaction is carried out to generate nitric oxide, the nitrogen and the nitric oxide in the electrolytic cell 5 are sprayed out through the purging piece 7 together with the air inlet through the circulating pipeline 8, the flow of the gas in the circulating pipeline 8 is 2.5L/min, the gas generated on the electrode 6 is blown away, the nitric oxide sequentially enters the desalination mist removal membrane 17, the Nafion membrane 18 and the cleaning filter 19 after the concentration of the nitric oxide meets the requirement, the purified nitric oxide enters the respiration simulation device, and when a user exhales, the two respiration simulation components are in an inflated state; when a user inhales, one respiration simulation component is in a deflation state, the other respiration simulation component is still in an inflation state, the simulation of respiration action is realized, nitric oxide is released, and the concentration of released NO is 6300 ppm;

(III) after the release of nitric oxide is stopped, the gas-liquid separator 11 enters a working state, the electrolyte flows through the switching valve 13 through the first pipeline 15 and enters the gas-liquid separator 11 for gas-liquid separation, the electrolyte flows back into the electrolytic cell 5 through the second pipeline 16, and the air carrier gas discharges the gas separated by the gas-liquid separator 11 to NO _x The purification device 25 is used for refluxing the electrolyte into the electrolytic cell 5, and the working state time is 20 min; after the working state is finished, the switching valve 13 is switched, the gas-liquid separator 11 enters the temporary stopping state, gas in the electrolytic cell 5 flows through the switching valve 13 through the second pipeline 16, enters the gas-liquid separator 11 to purge residual electrolyte, the electrolyte flows back into the electrolytic cell 5 through the first pipeline 15, and the temporary stopping state lasts for 2 min;

In step (I), the method of electrolytic reaction comprises: and applying an excitation current 7 times of the set value to the electrode 6, adjusting to the set current after lasting for 2.5min, wherein the set current is 200mA, and NO is stably output within 4.6 min.

Example 6

The present embodiment provides a system apparatus for realizing stable output of nitric oxide, which is based on an embodiment, wherein the breathing simulation apparatus includes two breathing simulation components.

The material of the nitrogen making membrane comprises brominated polycarbonate, and the average pore diameter of the nitrogen making membrane is 0.015 mu m; the area of the separation membrane in the gas-liquid separator 11 was 5000cm ² . The buffer solution is boric acid-borax buffer solution, and the molar concentration of the buffer solution in the electrolyte is 3 mol/L. The nitrogen source is potassium nitrite, and the molar concentration of the potassium nitrite in the electrolyte is 5 mol/L. The catalyst is a metal-based complex, the central atom of the metal-based complex is a cobalt-based atom, the ligand of the metal-based complex is bis (2-aminomethyl pyridine) -propionic acid, and the molar concentration of the catalyst in the electrolyte is 7 mmol/L. The electrodes 6 are all stainless steel coated with ruthenium iridium alloy coatings.

The material of the salt mist removing film 17 is mixed cellulose ester, and the average pore diameter is 1.6 μm. NO ₂ In the material of the conversion filter element, the carrier is silica gel, the reducing vitamin comprises vitamin E, and each 100g of the carrier is coated with 15g of the reducing vitamin.

compressed gas sequentially enters a water vapor filter 1 and a dust filter 2, water vapor and dust are respectively removed, then the compressed gas enters a nitrogen making device 3 for separation, and nitrogen with the volume concentration of 99.9% is obtained after the separation; nitrogen is introduced into the electrolyte through the air inlet pipeline 4, the flow of the nitrogen is 600mL/min, the gas on the sweeping electrode 6 is blown out, an electrolytic reaction is generated to generate nitric oxide, the nitrogen and the nitric oxide in the electrolytic cell 5 are sprayed out through the sweeping part 7 together with the air inlet through the circulating pipeline 8, the flow of the gas in the circulating pipeline 8 is 3L/min, the gas generated on the electrode 6 is blown away, the nitric oxide sequentially enters the desalination mist removal membrane 17, the Nafion membrane 18 and the cleaning filter 19 after the concentration of the nitric oxide meets the requirement, the purified nitric oxide enters the respiration simulation device, and when a user exhales, the two respiration simulation components are in an inflated state; when a user inhales, one breathing simulation component is in a deflation state, the other breathing simulation component is still in an inflation state, the breathing action is simulated, nitric oxide is released, and the concentration of released NO is 10400 ppm;

(III) after the release of nitric oxide is stopped, the gas-liquid separator 11 enters a working state, the electrolyte flows through the switching valve 13 through the first pipeline 15 and enters the gas-liquid separator 11 for gas-liquid separation, the electrolyte flows back into the electrolytic cell 5 through the second pipeline 16, and the air carrier gas discharges the gas separated by the gas-liquid separator 11 to NO _x The purification device 25 is used for refluxing the electrolyte into the electrolytic cell 5, and the working state time is 18 min; after the working state is finished, the switching valve 13 is switched, the gas-liquid separator 11 enters the temporary stopping state, gas in the electrolytic cell 5 flows through the switching valve 13 through the second pipeline 16, enters the gas-liquid separator 11 to purge residual electrolyte, the electrolyte flows back into the electrolytic cell 5 through the first pipeline 15, and the temporary stopping state lasts for 1.6 min;

In step (I), the method of electrolytic reaction comprises: and applying an excitation voltage 8 times of the set value to the electrode 6, adjusting to the set voltage after lasting for 3min, wherein the set voltage is 3.0V, and NO is stably output within 5 min.

The applicant declares that the above description is only a specific embodiment of the present invention, but the scope of the present invention is not limited thereto, and it should be understood by those skilled in the art that any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are within the scope and disclosure of the present invention.

Claims

1. The system device for realizing stable output of nitric oxide is characterized by comprising a generating unit, a purifying unit and an output unit, wherein the generating unit comprises an electrolytic cell and a gas-liquid separator which are circularly connected; the output unit comprises a breathing simulation device;

and after the electrolytic cell stops generating the nitric oxide, the gas-liquid separator removes the residual nitric oxide in the electrolytic cell.

2. The system of claim 1, wherein the breathing simulation device comprises at least two breathing simulation components;

preferably, the breathing simulation assembly comprises a screw rod pulling piece and an air bag, wherein the screw rod pulling piece is used for pressing and pulling the air bag;

preferably, the air bag is connected with a two-position three-way switching valve, and the air bag is connected to a working port of the two-position three-way switching valve;

preferably, the air outlet ends of the purification units are respectively and independently connected to the air charging ports of the two-position three-way switching valves;

preferably, the output unit further comprises NO ₂ The gas outlets of two-position three-way switching valves in the breath simulation device converge into one path to be connected with NO ₂ The screw rod lifting piece lifts the air bag, the air outlet of the two-position three-way switching valve is closed, the inflation inlet is opened, and air enters the air bag; the screw rod pulling piece presses the air bag, the air outlet is opened, the inflation inlet is closed, and the air is discharged out of the air bag and passes through NO ₂ Discharging the conversion filter element device;

preferably, a pressure sensor is arranged on the air bag and used for detecting the pressure in the air bag;

preferably, said NO ₂ The conversion filter element device comprises a cylinder body; the cylinder is internally divided into at least two baffling cavities, the baffling cavities axially penetrate through the cylinder along the cylinder, and NO is filled in the baffling cavities ₂ One end of each of two adjacent baffling cavities is communicated with each other, and gas enters the cylinder body and flows through the cylinder body in a serpentine baffling mode in sequenceThe baffling cavity;

preferably, said NO ₂ The conversion filter element material comprises a carrier and reductive vitamins coated on the surface of the carrier;

preferably, the carrier comprises one or a combination of at least two of silica gel, molecular sieve, alumina, sponge, cotton or foaming resin;

preferably, the reducing vitamin comprises one or a combination of at least two of vitamin C, vitamin E or vitamin A;

preferably, 5-50 g of reducing vitamin is coated on each 100g of carrier.

3. The system-device of claim 2, wherein the NO ₂ The air outlet end of the conversion filter element device is connected with a breathing machine through a breathing pipeline, and the breathing pipeline is divided into an independent incoming pipeline and an independent outgoing pipeline which are connected with the breathing machine;

preferably, a standby device is further connected to the incoming pipeline;

preferably, the standby device comprises a gas cylinder which is connected into the incoming pipeline through a standby branch;

4. The system set forth in any one of claims 1 to 3, further comprising a nitrogen production unit comprising a filtration device and a nitrogen production device connected in series in a gas flow direction;

preferably, the filtering device comprises a water vapor filter and a dust filter which are connected in sequence along the gas flow direction;

preferably, the nitrogen making device comprises a nitrogen making membrane, and the gas enters the nitrogen making membrane and is separated to obtain nitrogen;

preferably, the material of the nitrogen making film comprises any one or a combination of at least two of poly (4-methyl-1-pentene), brominated polycarbonate, polypropylene, polyimide and polydimethylsiloxane;

preferably, the average pore diameter of the nitrogen-making film is 0.005-0.02 mu m.

5. The system set forth in any one of claims 1 to 4, wherein said electrolytic cell comprises a housing, said housing being filled with an electrolyte, said housing having at least one pair of electrodes immersed in said electrolyte disposed therein;

preferably, the electrolytic cell is externally connected with an air inlet pipeline, and a nitrogen outlet of the nitrogen making device is connected to the electrolytic cell through the air inlet pipeline;

preferably, a nitrogen flow regulating valve is arranged on the air inlet pipeline;

preferably, the shell is externally connected with an air outlet pipeline, and the inlet end of the air outlet pipeline is positioned above the liquid level;

preferably, the electrolytic cell comprises a circulating pipeline, the inlet end of the circulating pipeline is positioned above the liquid level in the shell, the outlet end of the circulating pipeline is connected to an air inlet pipeline, and gas in the electrolytic cell circularly flows through the circulating pipeline;

preferably, a purging piece is arranged in the electrolytic cell and used for purging the electrode;

preferably, the purge is located below the electrode;

preferably, the blowing member comprises an open box body, and the box body is filled with air stones;

preferably, the opening direction of the box body faces to the corresponding electrode;

preferably, the air inlet pipeline and the circulating pipeline are converged into one pipeline and then are respectively connected to the purging parts;

preferably, a circulating pump is arranged on the circulating pipeline;

preferably, the electrolytic cell is circularly connected with the gas-liquid separator through a first pipeline and a second pipeline, and the first pipeline extends into the position below the liquid level in the shell; the second pipeline is connected above the liquid level in the shell;

preferably, the first pipeline and the second pipeline are both connected to a switching valve at the same time, and the switching valve is used for switching the working state and the temporary stop state of the gas-liquid separator; the working state comprises: electrolyte flows through a switching valve through the first pipeline and enters the gas-liquid separator for gas-liquid separation, and the electrolyte flows back into the electrolytic cell through the second pipeline; the critical standstill state comprises: gas in the electrolytic cell flows through the switching valve through the second pipeline, enters the gas-liquid separator, purges residual electrolyte, and the electrolyte flows back into the electrolytic cell through the first pipeline;

preferably, the gas-liquid separator is connected with an air pump, and the air pump injects carrier gas into the gas-liquid separator for bringing the separated gas out of the gas-liquid separator;

preferably, the first line is provided with a filter, the filter being located between the electrolytic cell and the switching valve;

preferably, an electromagnetic valve is arranged on the first pipeline and positioned between the filter and the switching valve;

preferably, a gas-liquid dual-purpose pump is arranged on the first pipeline, and the gas-liquid dual-purpose pump is positioned between the switching valve and the gas-liquid separator;

preferably, the area of the separation membrane in the gas-liquid separator is 1000-50000 cm ² 。

6. The system set forth in claim 5, wherein the electrolyte comprises a buffer, a nitrogen source, and a catalyst, wherein the catalyst comprises a metal-based complex; the central atom of the metal-based complex is a metal-based atom, and the ligand of the metal-based complex is a nitrogen-containing multi-site ligand;

preferably, the buffer solution comprises one or a combination of at least two of 4-hydroxyethyl piperazine ethanethiosulfonic acid buffer solution, 3-morpholine propanesulfonic acid buffer solution, tris (hydroxymethyl) aminomethane, citrate buffer solution, phosphate buffer solution, boric acid-borax buffer solution or organic buffer solution;

preferably, the molar concentration of the buffer solution in the electrolyte is 0.01-3 mol/L;

preferably, the nitrogen source comprises nitrite;

preferably, the nitrite comprises an inorganic nitrite and/or an organic nitrite;

preferably, the molar concentration of the nitrogen source in the electrolyte is 0.01-5 mol/L;

preferably, the metal-based atoms include one or a combination of at least two of copper, iron, titanium, chromium, manganese, cobalt, or nickel;

preferably, the nitrogen-containing multi-site ligand comprises one or a combination of at least two of tris (2-pyridylmethyl) amine, 1,4, 7-triazacyclononane, 1,4, 7-trimethyl-1, 4, 7-triazacyclononane, tris (2-aminoethyl) amine, tris (2-dimethylaminoethyl) or bis (2-aminomethylpyridine) -propionic acid;

preferably, the molar concentration of the catalyst in the electrolyte is 1-15 mmol/L;

preferably, the electrode plate is a single-component conductive material or a substrate coated with a conductive material;

preferably, the conductive material comprises one or a combination of at least two of platinum, gold, carbon, glassy carbon, stainless steel, ruthenium iridium alloy or boron-doped diamond;

7. The system-installation of any one of claims 3 to 6, wherein the purification unit comprises a purification membrane module and a clean filter connected in series in the gas flow direction;

preferably, the purification membrane module comprises a desalination mist membrane and a Nafion membrane which are sequentially connected along the gas flow direction;

preferably, the material of the salt and fog removing membrane comprises any one or a combination of at least two of polytetrafluoroethylene, polyvinylidene fluoride, polyether sulfone, mixed cellulose ester, organic nylon 6 or organic nylon 66;

preferably, the average pore diameter of the salt mist removing film is 0.1-2 μm;

preferably, the purification unit further comprises NO _x A gas outlet end of the gas-liquid separator is connected with NO _x A purification device;

preferably, a pressure relief branch pipe is externally connected to a pipeline connecting the clean filter and the breathing simulation device, and the pressure relief branch pipe is connected to the NO _x A purification device;

preferably, said NO _x The purification device is filled with alumina loaded with potassium permanganate;

preferably, the potassium permanganate-supporting alumina is spherical in shape;

preferably, the inhalation pipeline is provided with a concentration sensor and a flow rate sensor, the concentration sensor is used for detecting the concentration of nitric oxide in the inhalation pipeline, and the flow rate sensor is used for detecting the flow rate of nitric oxide in the inhalation pipeline;

preferably, the ventilator is provided with a monitoring sensor, and the monitoring sensor is used for detecting the tidal volume and the breathing ratio of the ventilator;

8. An output method of the system device for realizing stable output of nitric oxide according to any one of claims 1 to 7, wherein the output method comprises:

9. The output method according to claim 8, wherein the output method specifically comprises:

the method comprises the following steps that (I) compressed gas sequentially enters a water vapor filter and a dust filter, water vapor and dust are removed respectively, then the compressed gas enters a nitrogen making device for separation, and nitrogen is obtained after separation; nitrogen is introduced into the electrolyte through the air inlet pipeline, gas on the electrode is swept, an electrolytic reaction is carried out to generate nitric oxide, the nitrogen and the nitric oxide in the electrolytic cell are sprayed out through the sweeping piece together with the air inlet through the circulating pipeline, the gas generated on the electrode is blown away, the nitric oxide sequentially enters the desalination mist removal membrane, the Nafion membrane and the clean filter after the concentration of the nitric oxide meets the requirement, the purified nitric oxide enters the respiration simulation device, and the respiration simulation component is in an inflated state when a user exhales; when a user inhales, at least one breathing simulation component is in a deflation state, so that the breathing simulation action is simulated and nitric oxide is released;

(II) a concentration sensor and a flow rate sensor respectively detect the concentration and the flow rate of nitric oxide in the inhalation pipeline, and a detection sensor detects the tidal volume and the respiratory rate of the respirator; the controller calculates the capacity of the air bag and the flow rate of the nitric oxide according to the flow rate of the nitric oxide, the tidal volume of the breathing machine and the breathing ratio of the breathing machine, and feeds back and controls the lifting degree of the screw rod lifting piece; the controller controls the voltage and the current of the electrolytic cell according to the concentration feedback of the nitric oxide, and when the concentration of the nitric oxide needs to be increased, the controller controls the voltage and the current of the electrolytic cell to be increased;

(III) after the release of nitric oxide is stopped, the gas-liquid separator enters a working state, the electrolyte flows through the switching valve through the first pipeline and enters the gas-liquid separator for gas-liquid separation, the electrolyte flows back into the electrolytic cell through the second pipeline, and the carrier gas discharges the gas separated by the gas-liquid separator to NO _x The purification device is used for refluxing the electrolyte into the electrolytic cell; after the working state is finished, the switching valve is switched, the gas-liquid separator enters the temporary stop state, gas in the electrolytic cell flows through the switching valve through the second pipeline and enters the gas-liquid separator to purge residual electrolyte, and the electrolyte is purged through the first pipelineThe pipeline flows back into the electrolytic cell;

10. The output method according to claim 9, wherein in the step (I), the volume concentration of the nitrogen is more than or equal to 99.0%;

preferably, the flow rate of the nitrogen is 50-600 mL/min;

preferably, the flow rate of the gas in the circulating pipeline is 0.5-3L/min;

preferably, the method of the electrolytic reaction comprises: applying an excitation current or an excitation voltage higher than a set value to the electrode, and after a period of time, adjusting to the set current or the set voltage, wherein NO is stably output in a short time;

preferably, the excitation current or the excitation voltage is 2-8 times of a set value;

preferably, the excitation current or the excitation voltage acts for 0.5-3 min;

preferably, the set current is 0-300 mA, and does not include 0;

preferably, the set voltage is 1.4-3.0V;

preferably, the NO is stably output within 2-10 min;

preferably, in the step (III), the time of the working state is less than or equal to 20 min;

preferably, in step (iii), the carrier gas is air;

preferably, in the step (III), the time of the temporary stop state is 0.5-2 min.