CN114916534A - Mesenchymal stem cell active factor packaging structure - Google Patents
Mesenchymal stem cell active factor packaging structure Download PDFInfo
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- CN114916534A CN114916534A CN202210128576.0A CN202210128576A CN114916534A CN 114916534 A CN114916534 A CN 114916534A CN 202210128576 A CN202210128576 A CN 202210128576A CN 114916534 A CN114916534 A CN 114916534A
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- freezing
- tank body
- disc
- mesenchymal stem
- transfer container
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W90/00—Enabling technologies or technologies with a potential or indirect contribution to greenhouse gas [GHG] emissions mitigation
- Y02W90/10—Bio-packaging, e.g. packing containers made from renewable resources or bio-plastics
Abstract
The invention discloses a mesenchymal stem cell active factor packaging structure which comprises a liquid nitrogen freezing tank, wherein the liquid nitrogen freezing tank comprises a buffer type tank body base, a freezing tank body, a cell factor transfer container, a guide storage disc and a freezing gas extraction mechanism, the upper end of the buffer type tank body base is connected with the bottom of the freezing tank body, the cell factor transfer container is arranged on one side of the freezing tank body and comprises a container body and a pneumatic lifting mechanism arranged on the container body, and a display screen and a control button are arranged on the surface of the container body. When the liquid nitrogen freezing tank designed by the invention is used for taking out the cell factors, the cell factors can be transferred into a safer cell factor transfer container in advance, and the frozen gas is pumped out, so that the working personnel can take out the cell factors in a targeted manner on the basis of not wearing protective tools, and the liquid nitrogen freezing tank is simple to operate and convenient to use.
Description
Technical Field
The invention relates to the technical field of mesenchymal stem cell packaging and storage, in particular to a mesenchymal stem cell active factor packaging structure.
Background
Mesenchymal stem cells are pluripotent stem cells that have all of the commonalities of stem cells, namely self-renewal and multipotential differentiation capacity. The application is most in clinical application, and the combined application with hematopoietic stem cells can improve the success rate of transplantation and accelerate hematopoietic reconstitution. After a patient receives a large dose of chemotherapy, the mesenchymal stem cells and the hematopoietic stem cells are input together, so that the recovery time of the blood cells of the patient can be obviously accelerated, the patient is safe and has no adverse reaction, and the mesenchymal stem cells not only exist in bone marrow, but also exist in skeletal muscle, periosteum and trabecula. Because the tissue types of the differentiation of the mesenchymal stem cells are very wide, the mesenchymal stem cells need to be packaged, stored and processed by a special storage container because the mesenchymal stem cells are fragile.
However, the conventional mesenchymal stem cell active factor packaging and storing method has the following problems: (1) the cell active factors are mainly stored through a test tube and placed in a special liquid nitrogen freezing tank for refrigeration treatment, when the cell active factors need to be taken out, in order to prevent hands from being frozen by cooling gas, workers need to carry protective clothing, protective gloves and protective glasses for operation, the operation is complex, and the storage and the taking out of the cell active factors are inconvenient; (2) because there is a large amount of gas in the liquid nitrogen freezing jar and is inconvenient takes out corresponding test tube as required. For this reason, a corresponding technical scheme needs to be designed to solve the existing technical problems.
Disclosure of Invention
The invention aims to provide a mesenchymal stem cell active factor packaging structure, which solves the technical problems that a test tube is mainly used for storing a cell active factor and placing the cell active factor in a special liquid nitrogen freezing tank for refrigeration treatment, when the cell active factor needs to be taken out, in order to prevent cold gas from freezing hands, a worker needs to carry a protective garment, a protective glove and a protective mirror for operation, the operation is complicated, and the storage and the taking out of the cell active factor are inconvenient.
In order to achieve the purpose, the invention provides the following technical scheme: a mesenchymal stem cell active factor packaging structure comprises a liquid nitrogen freezing tank, wherein the liquid nitrogen freezing tank comprises a buffer type tank body base, a freezing tank body, a cell factor transfer container, a guide storage disc and a freezing gas extraction mechanism, the upper end of the buffer type tank body base is connected with the bottom of the freezing tank body, the cell factor transfer container is installed on one side of the freezing tank body and comprises a container body and a pneumatic lifting mechanism installed on the container body, a display screen and a control button are installed on the surface of the container body, the guide storage disc is of a two-section structure and is respectively a storage disc positioned in the freezing tank body and a lifting type placing disc positioned in the cell factor transfer container, a main board is arranged at the bottoms of the storage disc and the lifting type placing disc, and an electric push rod is installed on one side of the storage disc, the utility model discloses a cell factor transfer container, including freezing jar body, cell factor transfer container, electric putter's power take off end is connected with cytokine storage dish, two sets of cambered surface shroudings are still installed to freezing jar body and cell factor transfer container's junction symmetry, and are two sets of the outer end of cambered surface shrouding rotates with the inner wall of cell factor transfer container to be connected and the below is provided with driving motor, driving motor's upper end is connected with the lower extreme of cambered surface shrouding, freezing gaseous extraction mechanism includes aspiration pump and exhaust tube, the upper end that the aspiration pump is located the bottom of freezing jar body and exhaust tube alternates in cell factor transfer container.
As a preferred embodiment of the invention, the buffer type tank body base comprises a U-shaped base plate and buffer bases uniformly arranged on the U-shaped base plate, the buffer bases are in power connection with supporting columns, and the upper ends of the supporting columns are connected with the bottom of the freezing tank body.
As a preferred embodiment of the present invention, the buffer base has a double-layer structure and is respectively a first plate body and a second plate body, two sets of wavy buffer metal plates are symmetrically connected between the first plate body and the second plate body, and the wavy buffer metal plates have a wavy texture structure.
As a preferred embodiment of the present invention, a plurality of groups of notches are uniformly formed in the surface of the storage disk, and the plurality of groups of notches are annularly arranged and have magnetic attraction blocks fixed at the bottoms thereof.
As a preferred embodiment of the invention, a plurality of groups of placing openings are uniformly formed on the surface of the lifting placing plate, and the placing openings correspond to the notches one by one.
As a preferred embodiment of the present invention, the pneumatic lifting mechanism includes a blower and a gas pipeline connected to the blower, the gas pipeline is distributed annularly and is connected to a plurality of groups of branch pipes, the ends of the branch pipes are located in the placing opening, and a valve is installed at the gas outlet.
As a preferred embodiment of the present invention, the cytokine storage tray includes a main tray and a plurality of groups of storage test tubes uniformly arranged in the main tray, the storage test tubes are of a double-layer structure and include an outer tube located at an outer side and a containing test tube located at an inner side, a gauze is fixed at the bottom of the outer tube, a metal tray is arranged below the gauze, and a plurality of groups of springs are connected between the metal tray and a lower edge of the outer tube.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention designs a liquid nitrogen freezing tank for packaging and storing mesenchymal stem cell active factors, which comprises a buffer type tank body base, a freezing tank body, a guide storage disc, a cell factor transfer container and a freezing gas extraction mechanism, wherein the freezing tank body is erected on the buffer type tank body base, the aim of buffering and protecting the freezing tank body can be achieved through the buffer type tank body base, the phenomenon that the inside of the freezing tank body is inclined in the transferring process is avoided, the guide storage disc is of a two-section structure and is respectively a storage disc positioned in the freezing tank body and a lifting type placing disc positioned in the cell factor transfer container, when the cell factors need to be extracted, a worker controls a pushing mechanism arranged on one side of the storage disc to operate through a control button on the cell factor transfer container, and transfers a cell factor receiving disc on the storage disc into the lifting type placing disc through the pushing mechanism, then the frozen gas in the cell factor transfer container is pumped out through a frozen gas pumping mechanism, and the cell factor test tube to be selected is selected through a control button to be subjected to pneumatic lifting treatment, so that the cell factor test tube can be conveniently and safely taken out.
2. The liquid nitrogen freezing jar of this scheme design when taking out cytokine can shift in advance the cytokine to safer cytokine transfer container in and take out freezing gas outward for the staff carries out the cell factor of pertinence and takes out on the basis that need not to dress protective device, easy operation, convenient to use.
Drawings
FIG. 1 is an overall block diagram of the present invention;
FIG. 2 is a view of the structure of the buffering base according to the present invention;
FIG. 3 is a diagram of a steering memory disc structure according to the present invention;
FIG. 4 is a diagram of a memory disk structure according to the present invention;
FIG. 5 is a structural view of the storage tube according to the present invention.
In the figure, 1, a container body; 2. a pneumatic lifting mechanism; 3. a display screen; 4. a control button; 5. a storage disk; 6. lifting type placing plates; 7. a main board; 8. an electric push rod; 9. a cytokine receiving tray; 10. an arc surface sealing plate; 11. a drive motor; 12. an air pump; 13. an air exhaust pipe; 14. a U-shaped substrate; 15. a buffer base; 16. a support pillar; 17. a first plate body; 18. a second plate body; 19. a corrugated buffer metal plate; 20. a notch; 21. a placement port; 22. a blower; 23. a gas conduit; 24. a branch pipe; 25. a valve; 26. a master disk; 27. an outer tube; 28. receiving a test tube; 29. a screen; 30. a metal disc; 31. a spring.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1: referring to fig. 1-5, the present invention provides a technical solution: a mesenchymal stem cell active factor packaging structure comprises a liquid nitrogen freezing tank, wherein the liquid nitrogen freezing tank comprises a buffer type tank body base, a freezing tank body, a cell factor transfer container, a guide storage disc and a freezing gas extraction mechanism, the upper end of the buffer type tank body base is connected with the bottom of the freezing tank body, the cell factor transfer container is installed on one side of the freezing tank body and comprises a container body 1 and a pneumatic lifting mechanism 2 installed on the container body 1, a display screen 3 and a control button 4 are installed on the surface of the container body 1, the guide storage disc is of a two-section structure and is respectively a storage disc 5 positioned inside the freezing tank body and a lifting type placing disc 6 positioned in the cell factor transfer container, a main board 7 is arranged at the bottoms of the storage disc 5 and the lifting type placing disc 6, an electric push rod 8 is installed on one side of the storage disc 5, and the power output end of the electric push rod 8 is connected with a cell factor receiving disc 9, two sets of cambered surface shrouding 10 are still installed to the symmetry in the junction of freezing jar body and cytokine transfer container, and the outer end of two sets of cambered surface shrouding 10 rotates with the inner wall of cytokine transfer container to be connected and the below is provided with driving motor 11, and driving motor 11's upper end is connected with the lower extreme of cambered surface shrouding 10, and freezing gas extraction mechanism includes aspiration pump 12 and exhaust tube 13, and aspiration pump 12 is located the bottom of freezing jar body and the upper end interlude of exhaust tube 13 is in the cytokine transfer container.
Example 2: as shown in fig. 2: buffer tank body base includes U type base plate 14 and evenly installs buffer base 15 on U type base plate 14, and buffer base 15's power is connected with support column 16, and the upper end of support column 16 is connected with the bottom of freezing jar body.
The buffer base 15 is of a double-layer structure and is respectively a first plate body 17 and a second plate body 18, two groups of wavy buffer metal plates 19 are symmetrically connected between the first plate body 17 and the second plate body 18, the wavy buffer metal plates 19 are of a wavy texture structure, and the buffer capacity of the buffer base 15 can be improved through the wavy buffer metal plates 19.
A plurality of groups of notches 20 are uniformly formed in the surface of the storage disk 5, the plurality of groups of notches 20 are annularly arranged, and magnetic attraction blocks are fixed at the bottoms of the notches 20.
A plurality of groups of placing openings 21 are uniformly formed in the surface of the lifting placing plate 6, and the placing openings 21 correspond to the notches 20 one by one.
Example 3: as shown in fig. 3: pneumatic elevating system 2 includes air-blower 22 and the gas pipeline 23 that is connected with air-blower 22, gas pipeline 23 is cyclic annular distribution and is connected with a plurality of groups branch pipe 24, branch pipe 24's end is located places intraoral and gas outlet department and installs valve 25, through air-blower 22 with the air current leading-in to gas pipeline 23 in, when needs hold test tube 28 to certain group and select, can open through pressing the control button 4 that corresponds will reorganize valve 25, the air current is rushed out and will hold test tube 28 ejecting, it correspondingly takes to be convenient for the staff.
Specifically, cytokine storage dish 9 includes the master tray 26 and evenly sets up a plurality of groups in the master tray 26 and accomodates the test tube, accomodate the test tube and be bilayer structure and including the outer tube 27 that is located the outside and the test tube 28 that holds that is located the inboard, the bottom of outer tube 27 is fixed with gauze 29, gauze 29's below is provided with metal disc 30, be connected with a plurality of groups spring 31 between the lower edge of metal disc 30 and outer tube 27, when cytokine storage dish 9 is located storage tray 5, outer tube 27 erects in the opening part of notch 20, inhale the metal disc 30 through the magnetism in the notch 20 piece, make the inside cooling gas that exposes the jar body of gauze 29 enter into outer tube 27 inside and to holding the better cooling treatment of test tube 28.
When in use: the invention designs a liquid nitrogen freezing tank for packaging and storing mesenchymal stem cell active factors, which comprises a buffer type tank body base, a freezing tank body, a guide storage disc, a cell factor transfer container and a freezing gas extraction mechanism, wherein the freezing tank body is erected on the buffer type tank body base, the aim of buffering and protecting the freezing tank body can be achieved through the buffer type tank body base, the phenomenon that the inside of the freezing tank body is inclined in the transferring process is avoided, the guide storage disc is of a two-section structure and is respectively a storage disc positioned in the freezing tank body and a lifting type placing disc positioned in the cell factor transfer container, when the cell factors need to be extracted, a worker controls a pushing mechanism arranged on one side of the storage disc 5 to operate through a control button 4 on the cell factor transfer container, and transfers a cell factor receiving disc 9 on the storage disc 5 into the lifting type placing disc 6 through the pushing mechanism, then the frozen gas in the cell factor transfer container is pumped out through a frozen gas pumping mechanism, and the cell factor test tube to be selected is selected through a control button 4 to be subjected to pneumatic lifting treatment, so that the cell factor test tube can be taken out safely.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (7)
1. The utility model provides a mesenchymal stem cell active factor packaging structure, includes liquid nitrogen freezing jar, its characterized in that: the liquid nitrogen freezing tank comprises a buffering tank body base, a freezing tank body, a cell factor transfer container, a guiding storage disc and a freezing gas extraction mechanism, wherein the upper end of the buffering tank body base is connected with the bottom of the freezing tank body, the cell factor transfer container is installed on one side of the freezing tank body, the cell factor transfer container comprises a container body (1) and a pneumatic lifting mechanism (2) installed on the container body (1), a display screen (3) and a control button (4) are installed on the surface of the container body (1), the guiding storage disc is of a two-section structure and is respectively a storage disc (5) located inside the freezing tank body and a lifting placement disc (6) located in the cell factor transfer container, a main board (7) is arranged at the bottoms of the storage disc (5) and the lifting placement disc (6), and an electric push rod (8) is installed on one side of the storage disc (5), the power take off end of electric putter (8) is connected with cell factor storage plate (9), two sets of cambered surface shrouding (10) are installed to freezing jar body and cell factor transfer container's junction still symmetry, and are two sets of the outer end of cambered surface shrouding (10) is rotated with the inner wall of cell factor transfer container and is connected and the below is provided with driving motor (11), the upper end of driving motor (11) is connected with the lower extreme of cambered surface shrouding (10), freezing gaseous extraction mechanism includes aspiration pump (12) and exhaust tube (13), the upper end that aspiration pump (12) are located the bottom of freezing jar body and exhaust tube (13) alternates in cell factor transfer container.
2. The mesenchymal stem cell active factor packaging structure of claim 1, wherein: buffer tank body base includes U type base plate (14) and evenly installs buffer base (15) on U type base plate (14), the power of buffer base (15) is connected with support column (16), the upper end of support column (16) is connected with the bottom of freezing jar body.
3. The mesenchymal stem cell active factor packaging structure of claim 2, wherein: the buffer base (15) is of a double-layer structure and is respectively a plate body I (17) and a plate body II (18), two groups of wavy buffer metal plates (19) are symmetrically connected between the plate body I (17) and the plate body II (18), and the wavy buffer metal plates (19) are of wavy texture structures.
4. The mesenchymal stem cell active factor packaging structure of claim 1, wherein: the surface of the storage disc (5) is uniformly provided with a plurality of groups of notches (20), the notches (20) are annularly arranged, and the bottom of each notch is fixed with a magnetic attraction block.
5. The mesenchymal stem cell active factor packaging structure according to claim 4, wherein: a plurality of groups of placing openings (21) are uniformly formed in the surface of the lifting placing plate (6), and the placing openings (21) are in one-to-one correspondence with the notches (20).
6. The mesenchymal stem cell active factor packaging structure according to claim 5, wherein: pneumatic elevating system (2) include air-blower (22) and gas pipeline (23) that are connected with air-blower (22), gas pipeline (23) are the annular distribution and are connected with a plurality of groups branch pipe (24), the end of branch pipe (24) is located places mouthful (21) and gas outlet department installs valve (25).
7. The mesenchymal stem cell active factor packaging structure of claim 1, wherein: cell factor storage plate (9) include master disc (26) and evenly set up a plurality of groups in master disc (26) and accomodate the test tube, accomodate the test tube and be bilayer structure and including outer tube (27) that are located the outside and the test tube (28) that hold that are located the inboard, the bottom of outer tube (27) is fixed with gauze (29), the below of gauze (29) is provided with metal disc (30), be connected with between the lower edge of metal disc (30) and outer tube (27) a plurality of groups spring (31).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210128576.0A CN114916534A (en) | 2022-02-11 | 2022-02-11 | Mesenchymal stem cell active factor packaging structure |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210128576.0A CN114916534A (en) | 2022-02-11 | 2022-02-11 | Mesenchymal stem cell active factor packaging structure |
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| CN202210128576.0A Pending CN114916534A (en) | 2022-02-11 | 2022-02-11 | Mesenchymal stem cell active factor packaging structure |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030054331A1 (en) * | 2001-09-14 | 2003-03-20 | Stemsource, Inc. | Preservation of non embryonic cells from non hematopoietic tissues |
| CN111876374A (en) * | 2020-08-07 | 2020-11-03 | 湖州怡辉生态农业有限公司 | High-survival-rate sheep fertilized egg culture method for in-vitro culture of Hu sheep embryo |
| CN214962231U (en) * | 2021-03-30 | 2021-12-03 | 上海市杨浦区中心医院(同济大学附属杨浦医院) | Automatic storing and taking device for frozen storage tubes in liquid nitrogen tank |
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2022
- 2022-02-11 CN CN202210128576.0A patent/CN114916534A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030054331A1 (en) * | 2001-09-14 | 2003-03-20 | Stemsource, Inc. | Preservation of non embryonic cells from non hematopoietic tissues |
| CN111876374A (en) * | 2020-08-07 | 2020-11-03 | 湖州怡辉生态农业有限公司 | High-survival-rate sheep fertilized egg culture method for in-vitro culture of Hu sheep embryo |
| CN214962231U (en) * | 2021-03-30 | 2021-12-03 | 上海市杨浦区中心医院(同济大学附属杨浦医院) | Automatic storing and taking device for frozen storage tubes in liquid nitrogen tank |
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