CN114857862A - Slow release microsphere freeze drying device in preparation of liraglutide slow release microsphere - Google Patents

Slow release microsphere freeze drying device in preparation of liraglutide slow release microsphere Download PDF

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Publication number
CN114857862A
CN114857862A CN202210591812.2A CN202210591812A CN114857862A CN 114857862 A CN114857862 A CN 114857862A CN 202210591812 A CN202210591812 A CN 202210591812A CN 114857862 A CN114857862 A CN 114857862A
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CN
China
Prior art keywords
fixedly connected
sliding
rod
drying device
freeze
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Granted
Application number
CN202210591812.2A
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Chinese (zh)
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CN114857862B (en
Inventor
顾亚萍
贾昕
楼科尔
夏浩
张聪聪
王传跃
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Zhejiang Meihua Dingchang Pharmaceutical Technology Co ltd
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Zhejiang Meihua Dingchang Pharmaceutical Technology Co ltd
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Publication of CN114857862A publication Critical patent/CN114857862A/en
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Publication of CN114857862B publication Critical patent/CN114857862B/en
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    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00Drying solid materials or objects by processes not involving the application of heat
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/004Nozzle assemblies; Air knives; Air distributors; Blow boxes
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/001Handling, e.g. loading or unloading arrangements
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/02Applications of driving mechanisms, not covered by another subclass
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/06Chambers, containers, or receptacles
    • F26B25/14Chambers, containers, receptacles of simple construction
    • F26B25/18Chambers, containers, receptacles of simple construction mainly open, e.g. dish, tray, pan, rack
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B9/00Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards
    • F26B9/04Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards in presses or clamping devices

Abstract

The utility model provides a slow-release microsphere freeze-drying device in preparation of liraglutide slow-release microsphere, comprising a main body, spout A is seted up at the top of main part, the top fixedly connected with freezer of main part, set up stable clamping device on the spout A, through setting up stable clamping device, make through rotatory two-way threaded rod, make two sets of grip blocks carry out the centre gripping to the both sides of mould, the in-process that makes the mould remove through the centre gripping is more stable, simultaneously through setting up the anti-thread fixture block, prevent that two-way threaded rod from excessively rotating and causing certain damage to the mould, reach the effect of preventing the clamp injury, set up even freeze-drying device on the freezer. Through setting up even freeze-drying device, the messenger drives reciprocal lead screw rotation through motor C, makes reciprocal lead screw drive movable block and moves along the orbital inner wall of slip, makes the movable block drive the fan pivot and removes about, makes the inside air conditioning distribution of freezer more even, improves the refrigeration effect of freezer.

Description

Slow release microsphere freeze drying device in preparation of liraglutide slow release microsphere
Technical Field
The invention relates to the technical field of a freeze-drying device for preparing liraglutide sustained-release microspheres, in particular to a freeze-drying device for sustained-release microspheres in the preparation of liraglutide sustained-release microspheres.
Background
Liraglutide is marketed in 7 months 2009, and is a human glucagon-like peptide-1 (GLP-1) analogue produced by using yeast mainly through a gene recombination technology, and is a drug for treating diabetic patients.
In the prior art, in the process of preparing the liraglutide sustained-release microspheres, a freeze dryer is required to freeze-dry materials to achieve the effect of preparing the sustained-release microspheres, the materials are required to be poured into a mold, and the mold for placing the materials is manually placed into the freeze dryer by a worker to be freeze-dried, so that in the process of manually moving the mold by the worker, the mold is not stable enough to move, and the condition that the mold is splashed easily to cause material waste occurs.
Disclosure of Invention
Technical problem to be solved
The invention mainly aims to provide a sustained-release microsphere freeze-drying device in preparation of liraglutide sustained-release microspheres, which can clamp two sides of a mould through two groups of clamping plates, enables the mould to be more stable in the moving process through clamping, and prevents a bidirectional threaded rod from excessively rotating to damage the mould to a certain extent through arranging a reverse thread clamping block, thereby achieving the effect of preventing clamping injury.
(II) technical scheme
In order to achieve the above object, the freeze-drying device for sustained release microspheres in the preparation of liraglutide sustained release microspheres provided by the invention comprises a main body, wherein a chute a is formed at the top of the main body, one side of the chute a is fixedly connected with one side of a motor a, an output shaft of the motor a is fixedly connected with a threaded rod a, the other end of the threaded rod a is rotatably connected with one side of the inner wall of the chute a, a stable clamping device is arranged on the chute a, and the stable clamping device comprises:
the sliding block A is in threaded connection with the threaded rod A;
the top of the sliding block A is fixedly connected with the clamping seat;
one side of the clamping seat is fixedly connected with a sealing plate;
the top of the clamping seat is provided with a sliding groove B;
two sides of the inner wall of the sliding groove B are rotatably connected with two ends of the bidirectional threaded rod;
the bidirectional threaded rod is in threaded connection with the sliding block B, and the sliding block B is in sliding connection with the inner wall of the sliding groove B;
the top of the sliding block B is fixedly connected with the shell, and the inner wall of the shell is rotatably connected with two ends of the rotating rod A;
the outer wall of the rotating rod A is fixedly connected with a gear A;
the outer wall of the rotating rod A is fixedly connected with a gear B, the gear A is meshed with a rack A, the rack A is fixedly connected with one side of a sliding rod A, the gear B is meshed with the rack B, the rack B is fixedly connected with one side of the sliding rod B, the bottom of the sliding rod B is sleeved with an inner rod, and the bottom of the inner rod is fixedly connected with a reverse-thread clamping block;
the clamping plate is fixedly connected with one end of the sliding rod A.
Preferably, a freezing box is fixedly connected to the top of the main body, and an air conditioner is fixedly mounted on the top of the freezing box.
Preferably, one side of the clamping plate is fixedly connected with one end of a spring, the other end of the spring is fixedly connected with one side of the shell, one side of the top of the sliding rod B is fixedly connected with one end of the spring, and the other end of the spring is fixedly connected with the outer wall of the top of the shell.
Preferably, one side of the sliding rod B is in threaded connection with a bolt, one side of the sliding rod A is fixedly connected with the movable rod A, and one side of the sliding rod B is fixedly connected with the movable rod B.
Preferably, the freezing box is provided with an even freeze drying device, the even freeze drying device comprises a sliding rail, two ends of the sliding rail are fixedly connected with two sides of the inner wall of the freezing box, and two sides of the inner wall of the sliding rail are rotatably connected with two ends of a reciprocating screw rod.
Preferably, the reciprocating screw rod is connected with a moving block in a sliding manner, and the moving block is connected with the inner wall of the sliding track in a sliding manner.
Preferably, the bottom of the moving block is fixedly connected with a motor B, and an output shaft of the motor B is fixedly connected with a fan rotating shaft.
Preferably, a feed inlet is formed in one side of the freezing box, and a motor C is fixedly connected to the top of the main body.
Preferably, an output shaft of the motor C is fixedly connected with a rotating rod B, the rotating rod B is in transmission connection with a reciprocating screw rod through a belt, and a control button is fixedly mounted on the other side of the motor C.
Advantageous effects
The invention provides a freeze-drying device for sustained-release microspheres in preparation of liraglutide sustained-release microspheres. The method has the following beneficial effects:
(1) this slow-release microsphere freeze-drying device in liraglutide slow-release microsphere preparation through setting up stable clamping device, makes through rotatory two-way threaded rod, makes two sets of grip blocks carry out the centre gripping to the both sides of mould, and the in-process that makes the mould remove through the centre gripping is more stable, simultaneously through setting up the anti-thread fixture block, prevents that two-way threaded rod from excessively rotating and causing certain damage to the mould, reaches the effect of preventing pressing from both sides and hindering.
(2) This slow-release microsphere freeze-drying device in liraglutide slow-release microsphere preparation through setting up even freeze-drying device, makes to drive reciprocal lead screw rotation through motor C, makes reciprocal lead screw drive movable block and prolongs the orbital inner wall of sliding and move, makes the movable block drive the fan pivot and removes about, makes the inside air conditioning distribution of freezer more even, improves the refrigeration effect of freezer.
(3) This slow-release microsphere freeze-drying device in liraglutide slow-release microsphere preparation drives threaded rod A rotatory through motor A, makes one side touch control button that threaded rod A drove the grip slipper reach the effect that motor C began to operate, makes the effect of carrying out even freeze-drying.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
FIG. 1 is a schematic view of the overall structure of the apparatus of the present invention;
FIG. 2 is a schematic structural diagram of a front cross section of the apparatus of the present invention;
FIG. 3 is an enlarged view of portion A of FIG. 2 of the apparatus of the present invention;
FIG. 4 is a schematic view of the structure of the fan shaft, the motor B and the moving block of the present invention.
In the figure: 1. a main body; 2. a chute A; 3. a threaded rod A; 4. a motor A; 5. a freezer; 6. a uniform freeze drying device; 601. a sliding track; 602. a moving block; 603. a reciprocating screw rod; 604. a motor B; 605. a fan rotating shaft; 606. a feed inlet; 607. a belt; 608. a motor C; 609. a rotating rod B; 610. a control button; 7. an air conditioner; 8. a stable clamping device; 801. a slide block A; 802. a clamping seat; 803. a sealing plate; 804. a bidirectional threaded rod; 805. a chute B; 806. a slide block B; 807. a housing; 808. a slide bar A; 809. a travel bar A; 811. a rack A; 813. a clamping plate; 817. a rotating rod A; 818. a gear A; 819. a gear B; 820. a slide bar B; 821. an inner rod; 822. a reverse-thread fixture block; 823. a rack B; 825. the rod B is moved.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that all the directional indicators (such as up, down, left, right, front, and rear … …) in the embodiment of the present invention are only used to explain the relative position relationship between the components, the movement situation, etc. in a specific posture (as shown in the drawing), and if the specific posture is changed, the directional indicator is changed accordingly.
In addition, the descriptions related to "first", "second", etc. in the present invention are for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.
Referring to fig. 1-4, the present invention provides a freeze-drying apparatus for sustained-release microspheres in preparation of liraglutide sustained-release microspheres, which includes a main body 1, a chute a2 is formed at the top of the main body 1, one side of the chute a2 is fixedly connected with one side of a motor a4, an output shaft of the motor a4 is fixedly connected with a threaded rod A3, the other end of the threaded rod A3 is rotatably connected with one side of the inner wall of the chute a2, a freezing box 5 is fixedly connected to the top of the main body 1, and an air conditioner 7 is fixedly mounted at the top of the freezing box 5. The air conditioner 7 is an existing device, and the temperature inside the freezing box 5 is cooled through the air conditioner 7, so that the freezing effect is achieved.
Specifically, a stable clamping device 8 is arranged on the side wall of the sliding groove A2, the stable clamping device 8 comprises a sliding block A801, the sliding block A801 is in threaded connection with a threaded rod A3, the top of the sliding block A801 is fixedly connected with a clamping seat 802, one side of the clamping seat 802 is fixedly connected with a sealing plate 803, the top of the clamping seat 802 is provided with a sliding groove B805, two sides of the inner wall of the sliding groove B805 are rotatably connected with two ends of a bidirectional threaded rod 804, the bidirectional threaded rod 804 is in threaded connection with a sliding block B806, the sliding block B806 is slidably connected with the inner wall of the sliding groove B805, the top of the sliding block B806 is fixedly connected with a shell 807, the inner wall of the shell 807 is rotatably connected with two ends of a rotating rod A817, the outer wall of the rotating rod A817 is fixedly connected with a gear A818, the outer wall of the rotating rod A817 is fixedly connected with a gear B819, the gear A818 is meshed with a rack A811, one side of the sliding rod A808 is fixedly connected with a gear B819, the rack B is meshed with a rack B820, the bottom of slide bar B820 cup joints with interior pole 821, the bottom fixedly connected with anti-thread fixture block 822 of interior pole 821, the one end fixedly connected with grip block 813 of slide bar A808, the one end fixed connection of one side and the spring of grip block 813, the other end and the one side fixed connection of shell 807 of spring, the one end of top one side fixed connection spring of slide bar B820, the other end and the top outer wall fixed connection of shell 807 of spring, one side and the bolt threaded connection of slide bar B820, adjust the distance between slide bar B820 and the interior pole 821 through the bolt.
One side of the sliding rod A808 is fixedly connected with a moving rod A809, the moving rod A809 is in sliding connection with the inner wall of a sliding chute C, the sliding chute C is arranged on one side of the inner wall of the shell 807, and the sliding rod A808 can move left and right along the sliding chute C on the inner wall of the shell 807 through the sliding chute C.
One side of the sliding rod B820 is fixedly connected with a moving rod B825, the moving rod B825 is connected with the inner wall of the sliding groove D in a sliding manner, the sliding groove D is formed in the other side of the inner wall of the shell 807, and the sliding rod B820 can extend the sliding groove D to move up and down on the inner wall of the shell 807 through the sliding groove D.
Through setting up stable clamping device 8, make through rotatory two-way threaded rod 804, make two sets of grip blocks 813 carry out the centre gripping to the both sides of mould, make the in-process that the mould removed more stable through the centre gripping, simultaneously through setting up anti-thread fixture block 822, prevent that two-way threaded rod 804 from excessively rotating and cause certain damage to the mould, reach the effect of preventing pressing from both sides and hindering.
Further, the uniform freeze drying device 6 is arranged on the freezing box 5, the uniform freeze drying device 6 comprises a sliding track 601, two ends of the sliding track 601 are fixedly connected with two sides of the inner wall of the freezing box 5, two sides of the inner wall of the sliding track 601 are rotatably connected with two ends of a reciprocating lead screw 603, the reciprocating lead screw 603 is slidably connected with a moving block 602, the moving block 602 is slidably connected with the inner wall of the sliding track 601, the bottom of the moving block 602 is fixedly connected with a motor B604, an output shaft of the motor B604 is fixedly connected with a fan rotating shaft 605, a feeding hole 606 is formed in one side of the freezing box 5, a motor C608 is fixedly connected to the top of the main body 1, a rotating rod B609 is fixedly connected to an output shaft of the motor C608, the rotating rod B609 is in transmission connection with the reciprocating lead screw 603 through a belt, and a control button 610 is fixedly installed on the other side of the motor C608. Through setting up even freeze-drying device 6, make to drive reciprocal lead screw 603 through motor C608 and rotate, make reciprocal lead screw 603 drive movable block 602 and move along the inner wall of slip track 601, make movable block 602 drive fan pivot 605 and remove about, make the inside air conditioning distribution of freezer 5 more even, improve freezer 5's refrigeration effect. Meanwhile, the motor A4 drives the threaded rod A3 to rotate, so that the threaded rod A3 drives one side of the clamping seat 802 to touch the control button 610 to achieve the effect of starting the operation of the motor C608, and the effect of uniform freeze drying is achieved.
When the freezing device is used, a material to be frozen is introduced into a mold, the mold is placed at the top of the clamping seat 802, the stable clamping device 8 is arranged, a worker rotates the bidirectional threaded rod 804, the bidirectional threaded rod 804 drives the sliding block B806 to move along the inner wall of the sliding chute B805, the sliding block B806 drives the shell 807 to move, the clamping plate 813 arranged on one side of the shell 807 is in contact with the outer wall of the mold, meanwhile, the clamping plate 813 drives the sliding rod A808 to move outwards under the force of the mold, the sliding rod A808 drives the gear A818 to rotate through the rack A811, the gear A818 drives the rotating rod A817 to rotate, the rotating rod A817 drives the gear B819 to rotate, the gear B819 drives the rack B823 to move, the sliding rod B820 moves downwards, the reverse thread fixture block 822 arranged at the bottom of the sliding rod B820 is in contact with the top of the bidirectional threaded rod 804, and the effect of fixing the bidirectional threaded rod 804 is achieved, the messenger can't rotate two-way threaded rod 804, prevents that the staff from excessively rotating two-way threaded rod 804 and leading to causing the clamp to hinder to the mould, improves the stability that the mould removed through the centre gripping simultaneously.
After the mould is clamped, the motor A4 is started, the motor A4 drives the threaded rod A3 to rotate, the threaded rod A3 drives the sliding block A801 to move, the sliding block A801 extends the inner wall of the sliding groove A2 to move, the sliding block A801 drives the clamping seat 802 at the top to move, the clamping seat 802 drives the mould clamped at the top to move, the mould is stably moved to the inside of the freezing box 5, and the stability of movement in the material freezing process is improved.
After the grip slipper 802 moves to the inner wall of the freezer 5, one side of the grip slipper 802 is provided with a sealing plate 803 for sealing a feed inlet 606 arranged on one side of the freezer 5, thereby improving the sealing performance of the freezer 5 in the using process, and simultaneously, the air conditioner 7 is restarted, so that the air conditioner 7 discharges cold air to the inner wall of the freezer 5, thereby achieving the effect of rapidly reducing the temperature inside the freezer 5, and simultaneously, the motor B604 is started, so that the motor B604 drives the fan rotating shaft 605 to rotate, thereby achieving the air drying effect and improving the drying effect required by materials.
Meanwhile, after a sealing plate 803 is arranged on one side of the clamping seat 802 to seal a feeding hole 606 formed in one side of the freezing box 5, the other side of the clamping seat 802 can press a control button 610 arranged on one side of a motor C608, so that the motor C608 operates, the motor C608 drives a rotating rod B609 to rotate, the rotating rod B609 drives a reciprocating screw 603 to rotate through a belt 607, the reciprocating screw 603 drives a moving block 602 to move along the inner wall of the sliding track 601, the moving block 602 drives the motor B604 arranged at the bottom to move, and a fan rotating shaft 605 is driven to reciprocate left and right, so that cold air inside the freezing box 5 is distributed more uniformly, the cold air distribution efficiency is higher, and the freezing box 5 can uniformly freeze materials.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (9)

1. The utility model provides a slow-release microsphere freeze-drying device in preparation of liraglutide slow-release microsphere, includes main part (1), its characterized in that spout A (2) are seted up at the top of main part (1), one side of spout A (2) and one side fixed connection of motor A (4), the output shaft fixed connection threaded rod A (3) of motor A (4), the other end of threaded rod A (3) is rotated with inner wall one side of spout A (2) and is connected, set up on spout A (2) and stabilize clamping device (8), it includes to stabilize clamping device (8):
the sliding block A (801) is in threaded connection with the threaded rod A (3);
the clamping seat (802) is fixedly connected to the top of the sliding block A (801), and a sealing plate (803) is fixedly connected to one side of the clamping seat (802);
the top of the clamping seat (802) is provided with a sliding groove B (805), and two sides of the inner wall of the sliding groove B (805) are rotatably connected with two ends of the bidirectional threaded rod (804);
the bidirectional threaded rod (804) is in threaded connection with the sliding block B (806), the sliding block B (806) is in sliding connection with the inner wall of the sliding chute B (805), the top of the sliding block B (806) is fixedly connected with a shell (807), and the inner wall of the shell (807) is rotatably connected with two ends of a rotating rod A (817);
the gear A (818) is fixedly connected to the outer wall of the rotating rod A (817);
the outer wall of the rotating rod A (817) is fixedly connected with a gear B (819), the gear A (818) is meshed with a rack A (811), the rack A (811) is fixedly connected with one side of the sliding rod A (808), the gear B (819) is meshed with a rack B (823), the rack B (823) is fixedly connected with one side of the sliding rod B (820), the bottom of the sliding rod B (820) is sleeved with the inner rod (821), and the bottom of the inner rod (821) is fixedly connected with a reverse-thread fixture block (822);
and one end of the sliding rod A (808) is fixedly connected with the clamping plate (813).
2. The freeze-drying device for the slow-release microspheres in the preparation of liraglutide slow-release microspheres according to claim 1, wherein a freezing box (5) is fixedly connected to the top of the main body (1), and an air conditioner (7) is fixedly installed at the top of the freezing box (5).
3. The freeze-drying device for sustained-release microspheres in preparation of liraglutide according to claim 1, which is characterized in that: one side of the clamping plate (813) is fixedly connected with one end of a spring, the other end of the spring is fixedly connected with one side of the shell (807), one side of the top of the sliding rod B (820) is fixedly connected with one end of the spring, and the other end of the spring is fixedly connected with the outer wall of the top of the shell 807.
4. The freeze-drying device for the sustained-release microspheres in the preparation of liraglutide sustained-release microspheres according to claim 1, wherein one side of the sliding bar B (820) is connected with a bolt in a threaded manner, one side of the sliding bar A (808) is fixedly connected with a moving bar A (809), and one side of the sliding bar B (820) is fixedly connected with a moving bar B (825).
5. The freeze-drying device for the slow-release microspheres in the preparation of liraglutide according to claim 1, wherein the freezing chamber (5) is provided with a uniform freeze-drying device (6), the uniform freeze-drying device (6) comprises a sliding track (601), two ends of the sliding track (601) are fixedly connected with two sides of the inner wall of the freezing chamber (5), and two sides of the inner wall of the sliding track (601) are rotatably connected with two ends of a reciprocating screw rod (603).
6. The freeze-drying device for sustained-release microspheres in preparation of liraglutide according to claim 5, wherein the reciprocating lead screw (603) is slidably connected with a moving block (602), and the moving block (602) is slidably connected with the inner wall of the sliding track (601).
7. The freeze-drying device for the slow-release microspheres in the preparation of liraglutide according to claim 6, wherein the bottom of the moving block (602) is fixedly connected with a motor B (604), and an output shaft of the motor B (604) is fixedly connected with a rotating shaft (605) of a fan.
8. The freeze-drying device for the sustained-release microspheres in the preparation of liraglutide according to claim 7, wherein a feed inlet (606) is formed in one side of the freezing box (5), and a motor C (608) is fixedly connected to the top of the main body (1).
9. The freeze-drying device for the sustained-release microspheres in the preparation of liraglutide sustained-release microspheres according to claim 8, wherein an output shaft of the motor C (608) is fixedly connected with a rotating rod B (609), the rotating rod B (609) is in transmission connection with a reciprocating screw rod (603) through a belt (607), and the other side of the motor C (608) is fixedly provided with a control button (610).
CN202210591812.2A 2022-05-27 2022-05-27 Sustained release microsphere freeze drying device in preparation of liraglutide sustained release microsphere Active CN114857862B (en)

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