CN114848565B - 一种祛痘组合物及祛痘凝胶及其制备方法 - Google Patents
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Abstract
本申请涉及护肤品领域,具体公开了一种祛痘组合物及祛痘凝胶及其制备方法。祛痘组合物包括以下重量份的组分:0.5‑1份马齿苋提取物、0.3‑0.8份侧柏提取物、0.2‑0.6份姜根提取物、0.1‑0.5份烟酰胺、0.1‑0.4份甜菜碱水杨酸盐、0.05‑0.1份红没药醇。本申请的祛痘组合物具有疏通毛孔,抑菌杀菌,治愈速度快,治愈后不留疤痕或黑色素沉积的优点。
Description
技术领域
本申请涉及护肤品技术领域,更具体地说,它涉及一种祛痘组合物及祛痘凝胶及其制备方法。
背景技术
痘痘一般是指痤疮,是由于毛囊及皮脂腺阻塞、发炎引起的一种慢性炎症性皮肤病。在***时,体内荷尔蒙会刺激毛发生长,促进皮脂腺分泌更多油脂,毛发和皮脂腺因此堆积许多物质,使得油脂和细菌附着,引发皮肤红肿。痘痘不仅影响面容皮肤,如果不当挤压,除了会造成痘痘周边的组织破坏,引起更多的炎症,痘印明显等不良后果外,还可能会造成细菌随血液播散,引起更加严重的后果。
目前祛痘的方法有很多,例如激光祛痘,使用含有芦荟、茶树等天然植物的中药祛痘,还有使用水杨酸、波尔松等西药祛痘,但目前的祛痘方法均存在一定的局限性,激光祛痘法的治疗作用太强,而且只是物理方法将痘痘破除,不能从根部上治痘;中药祛痘法虽然安全,但祛痘时间长,祛痘后痘印不易完全去除;西药祛痘法副作用强,成本高。
针对上述中的相关技术,发明人发现研制一种治愈速度快,治愈后不留痘印的祛痘药物是亟待解决的问题。
发明内容
为了加快痘痘的治愈速度,且治愈后不留疤痕或不产生色素沉积,本申请提供一种祛痘组合物及祛痘凝胶及其制备方法。
第一方面,本申请提供一种祛痘组合物,采用如下的技术方案:
一种祛痘组合物,包括以下重量份的组分:0.5-1份马齿苋提取物、0.3-0.8份侧柏提取物、0.2-0.6份姜根提取物、0.1-0.5份烟酰胺、0.1-0.4份甜菜碱水杨酸盐、0.05-0.1份红没药醇。
通过采用上述技术方案,使用马齿苋提取物、侧柏提取物、姜根提取物等组分作为祛痘组合物的原料,各组分之间互相协同,改善祛痘组合物对痘痘的修复效果,提高愈合速度,并防止色素沉积,引发痘印的产生;马齿苋中富含大量的黄酮类、肾上腺素类、多糖类和各种维生素、氨基酸等化合物,马齿苋提取物能减少炎症因子白介素的分泌,具有一定的抗炎效果,从而舒缓皮肤炎症,抑制因干燥引起的皮肤瘙痒,还能抑制角质形成细胞和成纤维细胞的凋亡,并具有逆转角质形成细胞分化,还能保护人体皮肤细胞免受紫外线诱导的细胞损伤,起到舒缓、修复皮肤屏障的功能,马齿苋提取物具有较强的抗氧化能力和自由基清除活性,能促进胶原蛋白的合成,减少细纹,其还能抑制酪氨酸酶的活性,阻止黑色素的合成,防止痘印的引发;侧柏提取物对酪氨酸酶活性具有一定的抑制作用,能有效的清除DPPH自由基,总黄酮和总酚含量高,抗氧化性高,防黑色素沉积效果好;姜根提取物能具有抗炎症和抗氧化效果,增强肤色均匀度和光泽,淡化斑点,提亮皮肤,减少痘痘引起的发红,对抗色素沉着,减少炎症反应;烟酰胺能促进细胞新陈代谢,使含有黑色素的角质细胞脱离,淡化痘印,甜菜碱水杨酸盐拥有水杨酸和甜菜碱的双重功能,具有保湿、温和去角质、祛痘,抑菌的效果,红没药醇具有抗菌、抗炎作用,保护和治愈皮肤,加速皮肤的治愈过程,多种组分协同使用,加快痘痘的愈合,且愈合后不留痘印。
可选的,所述祛痘组合物中还包括以下重量份的组分:0.02-0.1份黄瓜籽油、0.2-0.6份绿玉树提取液、0.1-1份须津草提取液。
通过采用上述技术方案,黄瓜籽油能提高水分含水分,减少皮肤炎症,排出毛孔内的毒素,降低痤疮和皮疹的再发生率,绿玉树提取液能消炎、杀菌、止痒,消除红肿,防止瘙痒引起的皮肤损伤,须津草中含有黄酮、氨基酸等多种营养成分,主要能抑制血管扩张,防止痘痘消退后,毛细血管的扩张仍没法消退而产生痘印。
可选的,所述绿玉树提取液和须津草提取液均由以下方法制成:
(1)将新鲜的原料在水中浸泡后沥干,并立即放入温度为-(30~40)℃的环境中冷冻15-20h,然后在-(1~5)℃下粉碎成粉末;
(2)将步骤(1)中的粉末加入到质量浓度为15-18%的盐水中,通入超声波振荡3-5min后,室温浸渍17-20h,离心,获得提取液。
通过采用上述技术方案,将新鲜的绿玉树或须津草先在水中浸泡,使绿玉树和须津草的细胞充分吸水,然后在低温下冷冻后浸泡在盐水中,使绿玉树和须津草的细胞失水,细胞体积缩小,消除绿玉树和须津草细胞内多余的水分,提高有效物质的提取率,并且在盐水浸泡的过程中引入超声波振荡,不仅起到搅拌作用,还起到破坏细胞结构的作用,从而提高有效成分的提取率。
可选的,所述黄瓜籽油由以下方法制成:将黄瓜籽研磨破碎,与其1-2倍质量的去离子水混合,升温至105-110℃,搅拌20-30min,冷却后与正己烷按照料液比为1:8-10混合,在超声功率为100-110W的条件下,超声25-30min提取油脂,蒸馏去除残留溶剂,得毛油,加入毛油重4-5wt%活性白土,升温至80-90℃保温脱色15-20min,过滤,滤液减压浓缩,脱臭,得到黄瓜籽油。
通过采用上述技术方案,在此料液比下,油脂更容易被提取出来,当料液比继续增大,增加超声波破碎黄瓜籽细胞阻力,导致提取率下降;超声波功率增大,超声波对黄瓜籽细胞的细胞壁破碎作用强,更利于油脂的溶出,当超声波继续增大,物料在超声场中停留时间而降低,不利于油脂溶出,使得提取率降低。
可选的,所述祛痘组合物中还含有以下重量份组分:0.3-0.9份洋槐花提物、0.1-0.3份小茴香油和0.1-0.5份改性凹凸棒土。
通过采用上述技术方案,洋槐花含有多种抗菌消炎成分,如葡萄糖氧化酶,葡萄糖氧化酶氧化葡萄糖时会产生过氧化氢,过氧化氢可通过释放自身的氧原子,与病原菌细胞中许多酶的活性基团即巯基结合,使酶的化学结构发生改变,加上小茴香油中的有机酸可以抑制细菌的生长,从而对痘痘起到抗菌消炎的效果,且洋槐花提取物与马齿苋提取物协同作用,消炎、解毒作用更好;小茴香油中含挥发油、甾醇、糖苷、氨基酸,还有三萜、鞣质、强心苷、生物碱、皂苷、香豆素、挥发性碱、有机酸等多种植物化学物质,对真菌具有明显的广谱抗菌作用,能防止皮肤油脂分泌引发毛孔堵塞而造成细菌滋生,小茴香油还具有抗炎镇痛作用,能镇痛止痒,防止瘙痒引起抓挠,改性凹凸棒土具有较好的吸附作用,能增大祛痘组合物在痘痘上的持续时间,延长祛痘效果。
可选的,所述改性凹凸棒土由以下方法制成:
将凹凸棒土粉碎、酸处理后洗涤至中性,在320-400℃下焙烧1-2h,获得焙烧物,将焙烧物与硅烷偶联剂水溶液混合后在室温下处理0.5-1h,干燥后与三乙氧基辛基硅烷、孔雀石原液和牛油果核粉、海盐在负压0.05-0.1MPa下混合均匀,制得改性凹凸棒土。
通过采用上述技术方案,凹凸棒土经过酸处理后,凹凸棒土晶体通道中的杂质被去除,层间键力削弱,孔道疏通,使得其吸附性能提高,然后在高温下焙烧,凹凸棒石中的吸附水和沸石水逐渐蒸发,减少它们对凹凸棒土吸附效能的影响,并去除凹凸棒土中的杂质,使凹凸棒土内部结构更加疏松多孔,增大其比表面积,提高吸附效果;
经过硅烷偶联剂的有机改性后,能在凹凸棒土的表面覆盖一层有机分子膜,发生硅烷化,改变凹凸棒土的表面性能,使凹凸棒土呈现疏水效果,增强其在痘痘上的附着时间,在负压作用下,三乙氧基辛基硅烷、孔雀石原液、牛油果核粉和海盐进入凹凸棒土的孔道中,在三乙氧基辛基硅烷的黏附作用下,牛油果核粉和海盐负载在凹凸棒土上,同时也增大了凹凸棒土在肌肤上的持续时间,延长祛痘效果。
孔雀石原液能参与角质蛋白的合成与疏基的氧化作用,具有强保护性,能够清除过氧化阴离子,从根本上解决皮肤残留的铅汞等微量毒素,恢复健康皮肤爽滑性,使肌肤细腻、水嫩、红润,促进皮肤细胞组织新陈代谢;牛油果核粉中富含钾元素,能消除红肿,紧实面部肌肤。
可选的,将干洋槐花粉碎、过筛、脱脂、干燥,获得脱脂槐花粉,加入蒸馏水,升温至80-85℃,浸提5.5-6h,离心,重复浸提4-5次,合并浸提液,减压浓缩,将浓缩物与车前草提取物、金盏花油和淀粉辛烯基琥珀酸铝,微波处理2-3min,制得洋槐花提取物。
通过采用上述技术方案,干洋槐花经过脱脂、乙醇提取后,与车前草提取物、金盏花油和淀粉辛烯基琥珀酸铝混合,微波处理能保持有效成分中多糖的生物活性,提高洋槐花对痘痘的修复效果;车前草提取物具有抗菌效果,能抑制金黄色葡萄球菌和大肠杆菌的繁殖,金盏花油对皮肤具有舒缓保湿的作用,还能抗真菌、抗炎、收缩毛孔,降低毛孔扩张引起的色素沉积,减少痘印的产生几率。
第二方面,本申请提供一种祛痘凝胶,采用如下的技术方案:
一种祛痘凝胶,包括祛痘组合物。
通过采用上述技术方案,制成的祛痘凝胶具有较快的治痘效果,且痘痘愈合后不会引起色素沉积。
可选的,祛痘凝胶包括以下重量份的组分:2-8份祛痘组合物、1-3份皮肤调整剂、0.1-1份pH调节剂、0.1-0.3份黄原胶、0.01-0.02份透明质酸、0.1-0.3份己脒定二(羟乙基磺酸)盐、0.1-0.3份卡波姆、70-80份水、1-3份丁二醇。
通过采用上述技术方案,黄原胶能缓解皮肤干燥、抗氧化以及去除面部周围,卡波姆能提高祛痘凝胶的粘度,并改善祛痘凝胶的抗紫外效果,消炎抗菌,减轻痘痘在皮肤上的创口,防止留有疤痕,采用多种组分与祛痘组合物制成的祛痘凝胶,具有祛痘速度快,且不会产生痘印。
可选的,所述皮肤调整剂包括质量比为1:1-2的PEG-16澳洲坚果甘油酯类和β-葡聚糖。
通过采用上述技术方案,β-葡聚糖是天然植物胶聚糖,具有抗敏抗炎作用,与PEG-16澳洲坚果甘油酯类具有较好的配伍性,能提高皮肤保湿能力,还能起到抗氧化和保护皮肤免受紫外线伤害的作用,减少皮肤皱纹,提高皮肤抵御外界伤害的能力,刺激皮肤细胞活性,增强皮肤自身的免疫保护功能,高效修复皮肤;PEG-16澳洲坚果甘油酯类温度不刺激,在皮肤上形成油脂保护层,提高皮肤的滋润度和锁水效果,防止痘痘引发的局部皮肤黏膜充血、肿胀,造成毛囊孔扩张,引起皮肤粗糙、干燥。
可选的,所述pH调节剂为氨甲基丙醇、乙二胺、三乙醇胺中的一种或几种。
通过采用上述技术方案,调节祛痘凝胶的pH值,使祛痘凝胶的pH值更加适合面部皮肤,并保证各原料正常发挥功效。
第三方面,本申请提供一种祛痘凝胶的制备方法,采用如下的技术方案:
一种祛痘凝胶的制备方法,包括以下步骤:
将皮肤调整剂、pH调节剂、黄原胶、己脒定二(羟乙基磺酸)盐、透明质酸和水混合,搅拌加热至80-85℃,制得物料A,加入卡波姆和丁二醇,保温搅拌后降温至40-45℃时,加入祛痘组合物,搅拌均匀,即得祛痘凝胶。
通过采用上述技术方案,可使各组分充分混合,提高祛痘凝胶的质地均匀性,涂抹在肌肤上以后留存时间长。
综上所述,本申请具有以下有益效果:
1、由于本申请采用马齿苋提取物、姜根提取物、侧柏提取物等组分作为祛痘组合物的原料,由于马齿苋、姜根提取物具有抗炎症和抗氧化的作用,能舒缓抗敏,烟酰胺、侧柏提取物和马齿苋提取物能防止色素沉积,使制成的祛痘组合物能快速治愈痘痘,且痘痘治愈后不会引起黑色素沉积,减少痘印的产生。
2、本申请中优选采用绿玉树提取液、须津草提取液和黄瓜籽油作为祛痘组合物的原料,绿玉树提取液能止痒、消肿,须津草提取液能防止血管扩张而留有痘印,黄瓜籽油能提高皮肤含水量,排出毛孔毒素,防止痘痘反复发生。
3、本申请中优选采用洋槐花提取物、小茴香油和改性凹凸棒土作为祛痘组合物的原料,洋槐花提取物能抗菌消炎,小茴香油能抑制细菌生长,镇痛止痒,改性凹凸棒土能提高祛痘组合物在肌肤上的留存时间,延长治疗时间。
4、本申请中改性凹凸棒土由凹凸棒土经酸洗后硅烷偶联剂处理,负载孔雀石原液和牛油果核粉制成,凹凸棒土的孔道疏通,吸附力增大,且经过硅烷偶联剂处理后,呈现疏水性,提高改性凹凸棒土在肌肤的留存时间,防止肌肤出汗导致祛痘组合物从肌肤上脱离,改善祛痘组合物的祛痘持久性。
具体实施方式
改性凹凸棒土的制备例
制备例1-3中孔雀石原液选自广州市恬新生物科技有限公司,货号为KQS-001。
制备例1:将凹凸棒土粉碎,过20目筛,加入其质量6倍的盐酸溶液,在80℃下恒温搅拌1h进行酸处理,以1500r/min的转速离心10min,用去离子水洗涤至中性,在320℃下焙烧2h,获得焙烧物,将焙烧物与质量浓度为3%的硅烷偶联剂水溶液混合后,在室温下浸渍处理0.5h,80℃下干燥2h后与三乙氧基辛基硅烷、孔雀石原液和牛油果核粉、海盐在负压0.1MPa下混合均匀,制得改性凹凸棒土,凹凸棒土、三乙氧基辛基硅烷、孔雀石原液和牛油果核粉的质量比为1:0.08:0.2:0.4:0.1,牛油果核粉由牛油果核粉粉碎制成。
制备例2:与制备例1的区别在于,未添加孔雀石原液。
制备例3:与制备例1的区别在于,未添加牛油果核粉。
实施例
以下结合实施例对本申请作进一步详细说明。
以下实施例和对比例中,各原料的来源信息如下:马齿苋(PORTULACA OLERACEA)提取物选自广州朝夕生物科技有限公司,型号为ZX-POE,货号为APE-011;侧柏(THUJAORIENTALIS)提取物选自陕西横岭天然生物制品有限公司,货号为SXHLCBY;姜(ZINGIBEROFFICINALE)根提取物选自三原龙生物技术有限责任公司,货号为zt205;烟酰胺选自山西润康源生物科技有限公司,货号为V4、甜菜碱水杨酸盐选自武汉拉那医药化工有限公司,型号为DW3432;红没药醇选自广州市汇品源生物科技有限公司,CAS号515-69-5;洋槐(ROBINIA PSEUDACACIA)花提取物选自西安朗德生物科技有限公司,货号为LD-1704;小茴香油选自吉安市中香天然植物有限公司,货号为ZX-0124;车前草提取物选自西安天广源生物科技有限公司,货号为TGY-48263;金盏花油选自江西松盛源生物科技有限公司,型号为JZH-SSY;淀粉辛烯基琥珀酸铝选自郑州万搏化工产品有限公司,货号为8989。
实施例1:一种祛痘组合物,由以下重量的原料混合制成:0.5kg马齿苋提取物、0.3kg侧柏提取物、0.2kg姜根提取物、0.1kg烟酰胺、0.1kg甜菜碱水杨酸盐、0.05kg红没药醇。
实施例2:一种祛痘组合物,与实施例1的区别在于,原料用量如下:0.8kg马齿苋提取物、0.5kg侧柏提取物、0.4kg姜根提取物、0.3kg烟酰胺、0.2kg甜菜碱水杨酸盐、0.08kg红没药醇。
实施例3:一种祛痘组合物,与实施例1的区别在于,原料用量如下:1kg马齿苋提取物、0.8kg侧柏提取物、0.6kg姜根提取物、0.5kg烟酰胺、0.4kg甜菜碱水杨酸盐、0.1kg红没药醇。
实施例4:一种祛痘组合物,与实施例1的区别在于,原料中还包括0.02kg黄瓜籽油、0.2kg绿玉树提取液和0.1kg须津草提取液。
黄瓜籽油由以下方法制成:将黄瓜籽研磨破碎,与其1倍质量的去离子水混合,升温至105℃,搅拌30min,冷却后与正己烷按照料液比为1:8混合,在超声功率为100W的条件下,超声30min提取油脂,蒸馏去除残留溶剂,得毛油,加入毛油重4wt%活性白土,升温至80℃保温脱色20min,过滤,滤液减压浓缩,脱臭,得到黄瓜籽油。
绿玉树提取液由以下方法制成:
(1)将新鲜的绿玉树在水中浸泡2天后沥干,并立即放入温度为-30℃的环境中冷冻15-20h,然后在-1℃下粉碎成粉末;
(2)将步骤(1)中的粉末加入到质量浓度为18%的盐水中,通入超声波振荡3min后,室温浸渍17h,离心,将离心物压榨后与离心液混合,获得提取液,每千克的盐水对应120W的超声波,超声波频率为90KHz。
须津草提取液的制备方法如下:
(1)将新鲜的须津草在水中浸泡2天后沥干,并立即放入温度为-30℃的环境中冷冻15-20h,然后在-1℃下粉碎成粉末;
(2)将步骤(1)中的粉末加入到质量浓度为18%的盐水中,通入超声波振荡3min后,室温浸渍17h,离心,将离心物压榨后与离心液混合,获得提取液,每千克的盐水对应120W的超声波,超声波频率为90KHz。
实施例5:一种祛痘组合物,与实施例4的区别在于,原料中还包括0.1kg黄瓜籽油、0.6kg绿玉树提取液和1kg须津草提取液。
实施例6:一种祛痘组合物,与实施例4的区别在于,绿玉树提取液和须津草提取液在制备时,未在低温环境下冷冻,且在室温下粉碎。
实施例7:一种祛痘组合物,与实施例4的区别在于,绿玉树提取液和须津草提取液在制备时,未将粉末在盐水中浸泡。
实施例8:一种祛痘组合物,与实施例4的区别在于,绿玉树提取液和须津草提取液在制备时,使用盐水浸泡时,未通入超声波振荡。
实施例9:一种祛痘组合物,与实施例4的区别在于,还包括0.3kg洋槐花提取物、0.1kg小茴香油和0.1kg改性凹凸棒土,改性凹凸棒土由制备例1制成,洋槐(ROBINIAPSEUDACACIA)花提取物选自市售产品。
实施例10:一种祛痘组合物,与实施例4的区别在于,还包括0.9kg洋槐花提取物、0.3kg小茴香油和0.5kg改性凹凸棒土,改性凹凸棒土由制备例1制成,洋槐(ROBINIAPSEUDACACIA)花提取物选自市售产品。
实施例11:一种祛痘组合物,与实施例10的区别在于,改性凹凸棒土由制备例2制成。
实施例12:一种祛痘组合物,与实施例10的区别在于,改性凹凸棒土由制备例3制成。
实施例13:一种祛痘组合物,与实施例10的区别在于,洋槐花提取物由以下方法制成:
将干洋槐花粉碎、过筛、***脱脂、干燥,获得脱脂槐花粉,加入脱脂槐花粉5倍质量的蒸馏水,升温至80℃,浸提6h,离心,获得浸提液,重复浸提4次,合并浸提液,减压浓缩至浸提液总重的30%,将浓缩物与车前草提取物、金盏花油和淀粉辛烯基琥珀酸铝,微波处理2min,制得洋槐花提取物,浓缩物、车前草提取物、金盏花油和淀粉辛烯基琥珀酸铝的质量1:0.4:0.1:0.08。
实施例14:一种祛痘组合物,与实施例13的区别在于,洋槐花提取物制备时,未添加车前草提取物。
实施例15:一种祛痘组合物,与实施例13的区别在于,洋槐花提取物制备时,未添加金盏花油。
实施例16:一种祛痘组合物,与实施例10的区别在于,未添加洋槐花提取物。
实施例17:一种祛痘组合物,与实施例10的区别在于,未添加改性凹凸棒土。
实施例18:一种祛痘组合物,与实施例10的区别在于,未添加小茴香油。
实施例19:一种祛痘组合物,与实施例4的区别在于,未添加绿玉树提取液。
实施例20:一种祛痘组合物,与实施例4的区别在于,未添加须津草提取物。
实施例21:一种祛痘组合物,与实施例4的区别在于,未添加黄瓜籽油。
对比例
对比例1:一种祛痘组合物,与实施例1的区别在于,未添加侧柏提取物和红没药醇。
对比例2:一种祛痘组合物,与实施例1的区别在于,未添加马齿苋提取物。
对比例3:一种祛痘组合物,与实施例1的区别在于,未添加甜菜碱水杨酸盐。
对比例4:一种祛痘组合物,包括20kg牛油果树果脂、5kg黄柏提取物、6kg黑柳树皮提取物、8kg马齿苋提取物、5kg紫苏提取物、5kg积雪草提取物、8kg绿豆提取物。
应用例
应用例1:一种祛痘凝胶,其原料用量如下:2kg实施例1制成的祛痘组合物、1kg皮肤调整剂、0.1kg pH调节剂、0.1kg黄原胶、0.01kg透明质酸、0.1kg己脒定二(羟乙基磺酸)盐、0.1kg卡波姆、70kg水和1kg丁二醇。
上述祛痘凝胶的制备方法,包括以下步骤:
将皮肤调整剂、pH调节剂、黄原胶、己脒定二(羟乙基磺酸)盐、透明质酸和水混合,搅拌加热至80℃,制得物料A,加入卡波姆和丁二醇,保温搅拌后降温至40℃时,加入祛痘组合物,搅拌均匀,即得祛痘凝胶。
应用例2:与应用例1的区别在于,祛痘凝胶的原料用量如下:8kg实施例1制成的祛痘组合物、3kg皮肤调整剂、1kg pH调节剂、0.3kg黄原胶、0.02kg透明质酸、0.3kg己脒定二(羟乙基磺酸)盐、0.3kg卡波姆、80kg水和3kg丁二醇。
应用例3-26:与应用例1的区别在于,祛痘组合物的来源选择如表1所示。
表1实施例1-26中祛痘组合物的实施例选择
应用例 | 祛痘组合物的来源 | 应用例 | 祛痘组合物的来源 |
应用例1 | 实施例1 | 应用例14 | 实施例13 |
应用例2 | 实施例1 | 应用例15 | 实施例14 |
应用例3 | 实施例2 | 应用例16 | 实施例15 |
应用例4 | 实施例3 | 应用例17 | 实施例16 |
应用例5 | 实施例4 | 应用例18 | 实施例17 |
应用例6 | 实施例5 | 应用例19 | 实施例18 |
应用例7 | 实施例6 | 应用例20 | 实施例19 |
应用例8 | 实施例7 | 应用例21 | 实施例20 |
应用例9 | 实施例8 | 应用例22 | 实施例21 |
应用例10 | 实施例9 | 应用例23 | 对比例1 |
应用例11 | 实施例10 | 应用例24 | 对比例2 |
应用例12 | 实施例11 | 应用例25 | 对比例3 |
应用例13 | 实施例12 | 应用例26 | 对比例4 |
性能检测试验
试验一、斑贴试验
1.1试验样品:应用例1、应用例5、应用例10和应用例14制成的祛痘凝胶。
1.2受试者:选取36人(各试验样品使用同一批受试者)。
1.3试验方法:采用封闭式试验,取0.02g受试物置于斑贴器内,用低致敏胶带贴敷于受试者对象的手臂曲侧,试验区域至少为5cm×5cm,贴敷时让受试者伸直手臂,从下方往上贴,用手掌轻轻按压胶带,排出空气,使之紧贴皮肤,持续24h,空白对照组为不使用试样品。
1.4观察结果:分别在去除斑贴器后48h后根据下述判断标准进行判读,统计试验结果,试验结果如表2所示。
判读标准:(-)阴性反应;(+-)可疑反应:仅有轻度红斑;(+)弱阳性:红斑、浸润、可有少量丘疹;(++)强阳性:红斑、浸润、丘疹、水疱;(+++)极强阳性:红斑、浸润、丘疹,出现水疱、大疱。
表2斑贴试验结果
由表2内可知,由实施例1、实施例4、实施例9和实施例13制成的祛痘组合物制成祛痘凝胶后,斑贴试验安全,不刺激。
试验二、祛痘效果验证
2.1试验样品:应用例1-26制备的祛痘凝胶。
2.2受试者:选择脸部有痘受试者,平均分为26组,每组30人。
2.3试验方法:取祛痘凝胶,涂抹于受试者规定区域,用量为2mg/cm2,轻轻按摩至完全吸收即可,每天2次,连续使用14天,记录治疗效果,试验期间,受试者在试验部位不能涂抹任何化妆品。
2.4观察结果:受试者连续使用祛痘凝胶3天、7天、10天和14天时,在同一时间统计受试者痘印数量;并按照下式计算皮损率:皮损修复率=(治疗前皮损计数-治疗后皮损计数)/治疗前皮损计数×100%,治疗效果分为显效、有效和无效三个级别,其中显效是指皮损修复率为60-90%,症状减轻,有效是指皮损修复率为20-60%,症状改善,无效是指皮损修复率<20%,临床症状未改善,具体疗效如表3所示,其中皮损由视觉评估,主要包括炎症性丘疹+开放性粉刺+闭合性粉刺;并在连续使用祛痘凝胶的第3天、第7天、第10天和第14天时,对每组30名受试者面部痘印数进行统计。
表3祛痘凝胶的性能检测
实施例1-4中采用马齿苋提取物、侧柏提取物、烟酰胺等制成的祛痘组合物,在连续使用10天后,就能达到显效的祛痘效果,且使用后痘印数量少,说明祛痘凝胶不易引起黑色素沉积,降低痘印的产生。
应用例5-6与应用例1相比,分别使用实施例4和实施例5制备的祛痘组合物,还掺入了绿玉树提取液、须津草提取液和黄瓜籽油,表3内显示,应用例5和应用例6制备的祛痘组合物的祛痘效果得到改善,且痘印数量降低。
应用例7-9中分别采用实施例6-8制备的祛痘组合物,实施例6-8中在进行绿玉树提取液和须津草提取液的制备时,分别未进行低温冷冻、盐水浸泡和超声波振荡,应用例7制备的祛痘凝胶使用后,皮肤修复效果不佳,应用例8-9制备的祛痘凝胶,对于痘痘的去除效果均不及应用例1,痘印残留数量增多。
应用例10和应用例11中分别采用实施例9和实施例10制成的祛痘组合物,其中还添加了洋槐花提取物、小茴香油和改性凹凸棒土,与应用例1相比,在第10和第14天时,受试者的皮损修复率进一步增大,且痘印数值下降,说明本申请中祛痘凝胶的修复速度快,且修复彻底,不易引起色素沉积。
应用例12和应用例13分别采用实施例11和实施例12制成的祛痘组合物,实施例11和实施例12中分别使用制备例2和制备例3制成的改性凹凸棒土,参照表3内数据,应用例12和应用例13制成的祛痘组合物,对痘痘、丘疹等的修复效果下降,且痘印残留数量增多。
应用例14与应用例11相比,使用车前草提取物等制备洋槐花提取物,应用例14制成的祛痘凝胶对于面部的修复效果提升,在第14天时,皮损率修复率达到90%以上,且痘印残留数量降低至20个以下,修复效果进一步提升。
应用例15和应用例16与应用例14相比,制备洋槐花提取物时,分别未添加车前草提取物和金盏花油,表3内数据显示,应用例15和应用例16制成的祛痘凝胶对于面部的皮损修复率有轻微下降,痘印残留量比应用例14大,说明加入车前草提取物和金盏花油能进一步改善祛痘效果。
应用例17-19与应用例11相比,分别未添加洋槐花提取物、改性凹凸棒土和小茴香油,应用例17-19制备的祛痘凝胶对痘肌的改善效果不及应用例9,且不及应用例11,可见洋槐花提取物、改性凹凸棒土和小茴香油的添加,可以改善祛痘凝胶的祛痘效果。
应用例20-22中依次采用实施例19-21制备祛痘组合物,实施例19-21与应用例5相比,依次未添加绿玉树提取液、须津草提取液和黄瓜籽油,制成的祛痘组合物在第3天时的修复效果不及应用例1,且在后期第14天时修复效果减弱。
应用例23-25与应用例1相比,分别未添加侧柏提取物和红没药醇、马齿苋提取物、甜菜碱水杨酸盐,表3内数据显示,应用例23-25制备的祛痘凝胶对于的治愈效果减弱,且痘印残留数量增大。
应用例26中采用现有技术制备的一种祛痘组合物,对于痘肌的治疗效果不佳,且产生的痘印数量较多。
本具体实施例仅仅是对本申请的解释,其并不是对本申请的限制,本领域技术人员在阅读完本说明书后可以根据需要对本实施例做出没有创造性贡献的修改,但只要在本申请的权利要求范围内都受到专利法的保护。
Claims (5)
1.一种祛痘组合物,其特征在于,包括以下重量份的组分:0.5-1份马齿苋提取物、0.3-0.8份侧柏提取物、0.2-0.6份姜根提取物、0.1-0.5份烟酰胺、0.1-0.4份甜菜碱水杨酸盐、0.05-0.1份红没药醇、0.02-0.1份黄瓜籽油、0.2-0.6份绿玉树提取液、0.1-1份须津草提取液、0.3-0.9份洋槐花提取物、0.1-0.3份小茴香油和0.1-0.5份改性凹凸棒土;
所述改性凹凸棒土由以下方法制成:
将凹凸棒土粉碎、酸处理后洗涤至中性,在320-400℃下焙烧1-2h,获得焙烧物,将焙烧物与硅烷偶联剂水溶液混合后在室温下处理0.5-1h,干燥后与三乙氧基辛基硅烷、孔雀石原液和牛油果核粉、海盐在负压0.05-0.1MPa下混合均匀,制得改性凹凸棒土;
所述绿玉树提取液和须津草提取液均由以下方法制成:
(1)将新鲜的原料在水中浸泡后沥干,并立即放入温度为-(30~40)℃的环境中冷冻15-20h,然后在-(1~5)℃下粉碎成粉末;
(2)将步骤(1)中的粉末加入到质量浓度为15-18%的盐水中,通入超声波振荡3-5min后,室温浸渍17-20h,离心,获得提取液;
所述洋槐花提取物由以下方法制成:
将干洋槐花粉碎、过筛、脱脂、干燥,获得脱脂槐花粉,加入蒸馏水,升温至80-85℃,浸提5.5-6h,离心,重复浸提4-5次,合并浸提液,减压浓缩,将浓缩物与车前草提取物、金盏花油和淀粉辛烯基琥珀酸铝,微波处理2-3min,制得洋槐花提取物;
所述黄瓜籽油由以下方法制成:将黄瓜籽研磨破碎,与其1-2倍质量的去离子水混合,升温至105-110°C,搅拌20-30min,冷却后与正己烷按照料液比为1:8-10混合,在超声功率为100-110W的条件下,超声25-30min提取油脂,蒸馏去除残留溶剂,得毛油,加入毛油重4-5wt%活性白土,升温至80-90°C保温脱色15-20min,过滤,滤液减压浓缩,脱臭,得到黄瓜籽油。
2.一种祛痘凝胶,其特征在于,包含权利要求1所述的祛痘组合物。
3.根据权利要求2所述的祛痘凝胶,其特征在于,祛痘凝胶包括以下重量份的组分:2-8份祛痘组合物、1-3份皮肤调整剂、0.1-1份pH调节剂、0.1-0.3份黄原胶、0.01-0.02份透明质酸、0.1-0.3份己脒定二(羟乙基磺酸)盐、0.1-0.3份卡波姆、70-80份水、1-3份丁二醇。
4.根据权利要求3所述的祛痘凝胶,其特征在于,所述皮肤调整剂包括质量比为1:1-2的PEG-16澳洲坚果甘油酯类和β-葡聚糖。
5.权利要求4所述的祛痘凝胶的制备方法,其特征在于,包括以下步骤:
将皮肤调整剂、pH调节剂、黄原胶、己脒定二(羟乙基磺酸)盐、透明质酸和水混合,搅拌加热至80-85℃,制得物料A,加入卡波姆和丁二醇,保温搅拌后降温至40-45℃时,加入祛痘组合物,搅拌均匀,即得祛痘凝胶。
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