CN114796329A - 一种致力于原发性痛经中药暖宫贴及制备方法 - Google Patents
一种致力于原发性痛经中药暖宫贴及制备方法 Download PDFInfo
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Abstract
本发明公开了一种致力于原发性痛经中药暖宫贴及制备方法,包括依次叠加设置的离型纸、载药层、发热层和无纺布层;所述的发热层包括内袋和填充在内袋中的发热材料;所述的载药层与发热层相互复合,采用粘合或缝合的方法,用外袋包裹在载药层和发热层外,并用包装包裹在外袋之外;本发明将贴剂分为发热层和载药层两层,可有效控制贴剂的温度,使本品可以直接接触皮肤。
Description
技术领域
本发明涉及药贴技术领域,具体涉及一种致力于原发性痛经中药暖宫贴及制备方法。
背景技术
痛经是最常见的妇科症状之一,许多女性在生理期前后常会出现下腹部疼痛、坠胀,可伴腰痛或其他症状,严重者可出现休克症状。尤其在年轻女性中发病率非常高,严重者甚至会影响到正常工作、学习及生活。
传统的治疗方法中,西医主要是以镇痛、消炎为主,治标不治本;中医主要是以调理为主,疗效慢,易反复。现有的热敷药需要将药粉加热后用布包住,但是温度过高,不能直接敷在人体患处,需要晾凉后使用,使用时需要人保持不动,不能随意活动,而且很多用药的人由于身体不适,活动不便,用药困难。
发明内容
为了克服以上技术问题,本发明的目的在于提供一种致力于原发性痛经中药暖宫贴及制备方法,将贴剂分为发热层和载药层两层,可有效控制贴剂的温度,使本品可以直接接触皮肤。
为了实现上述目的,本发明采用的技术方案是:
一种致力于原发性痛经中药暖宫贴,包括依次叠加设置的离型纸1、载药层2、发热层3和无纺布层4;所述载药层2包括无纺布内袋和填充在内袋中的药物5,所述的发热层3包括无纺布内袋和填充在内袋中的发热材料6;8为压敏胶用于贴敷于皮肤。
所述的载药层2与发热层3相互复合,采用粘合剂7粘合或缝合的方法,用外袋包裹在载药层2和发热层3外,并用包装包裹在外袋之外;
所述载药层2用于装载的药物,包括附子、肉桂、川芎、防风、白芷、当归、五灵脂、独活、杜仲、木瓜;
配比为:附子30~50g、肉桂30~50g、川芎30~50g、防风30~50g、白芷30~50g、当归30~50g、五灵脂30~50g、独活30~50g、杜仲30~50g、木瓜30~50g。
所述发热材料6包括铁粉、活性炭、水、吸水树脂、蛭石和食盐;
所述内袋为无纺布。
所述的外袋为自粘性无纺布,为商业化产品;
所述的包装为塑料,如Kopp+铝膜+PE,具有良好的隔氧作用。
所述的发热层3制备方法为常规的,将发热材料6的各个组分混合均匀后填充在内袋中即可。
一种致力于原发性痛经中药暖宫贴的制备方法,包括以下步骤;
(1)按重量分别称取附子、肉桂、川芎、木瓜、防风,用粉碎机粉碎后过100目筛,各个药粉分别留用;
(2)按重量称取白芷饮片,用粉碎机粉碎后过50~100目筛,得白芷粉末,加入食用油进行浸提24h,过滤,得白芷提取物油液;
(3)按重量称取当归饮片,用粉碎机粉碎后过50~100目筛,得当归粉末,加入50~95%乙醇浸渍24h,以渗漉方式低温减压回收乙醇至尽,浓缩得到浸膏;按重量称取五灵脂、独活,分别加入8倍量水煎煮2h,随后加6倍量水煎煮1h,合并两次煎液,过滤,减压浓缩得到浸膏;按重量称取杜仲饮片,用粉碎机粉碎后过50~100目筛,得杜仲粉末,加入60%乙醇,超声提取,回收乙醇至尽,减压浓缩得到浸膏;
(4)将步骤(1)中所得的中药粉末和步骤(3)中所得的各浸膏按一定比例加入步骤(2)白芷提取物油液中,搅拌混合均匀,得到中药药膏;
(5)将步骤(4)中的药膏装入无纺布袋中,四周压制密封完整,得到载药层2;
(6)将制备的载药层2粘和在发热层3上,并在载药层2的另一面贴上离型纸1,装入真空包装袋密封,即获得原发性痛经中药暖宫贴。
所述无纺布袋采用无纺布制作,将发热填充物装入无纺布袋中,四周压制密封完整。
所述步骤(1)所述的食用油的量为白芷细粉重量的5~15倍。
所述步骤(1)渗漉速度为0.5~8ml/min。
所述步骤(1)所述的浓缩浸膏相对密度为0.8~1.30(60℃)。
所述步骤(3)超声条件是200Mpa,200Hz,50℃。
本发明的有益效果:
使用时,将外包装撕开,取出外袋,将背衬的离型纸1撕掉,贴于腹部,药物5透过无纺布作用在腹部,内包装袋中的发热材料6与空气中的氧气发生放热反应,使暖宫贴持续发热。
本发明针对现有技术的不足,通过对中药材的合理加工并合理配比制成载药体,通过发热层3的作用,从而达到有效的缓解女性原发性痛经的中药暖宫贴。
本发明的致力于原发性痛经的中药暖宫贴,是一种通过穴位物理温热催化药效的中药暖宫护理产品,它的温度可以稳定的维持在38℃~42℃之间,持续发热6小时,可以有效提高中药药效,达到温经驱寒的效果。本发明原料易于取得,配方合理。
中药暖宫贴原理在于经皮透过治疗,利用发热包促进药物释放并起到保温和缓解疼痛的效果。本发明采用同比例的各药材经提取有效成分并制备为药膏,可以发挥各药材的药效,以此得到更好的暖宫效果。其中用5-15倍食用油提取白芷细粉,相似相容原则白芷中有效成分挥发油提取效率上升,适度体积的食用油既保证药物有效成分能在短时间内溶出有保障后续的浓缩时间不致过长,以0.5-8ml/min速度渗漉能保证在较短时间更大程度提取出当归中的有效成分,而浓缩浸膏在0.8~1.30时粘稠度适中,制作所得的载药层便于药物释放及控制透皮吸收速度,在200Mpa,200Hz,50℃的超声条件下,能使药材有效成分最大限度溶出而避免破坏细胞壁造成更多杂质溶出。本发明基于铁与氧气和水发生的氧化还原反应,以铁,水,活性炭作为发热包的主要填充材料,再加入少量食盐作为反应促进剂,为了使发热温度持续稳定,加以蛭石保温。又因水与铁接触不够均匀,便采用吸水树脂与水先混合最后加入,使其水均匀持续接触铁并反应,且吸水树脂能够控制水分的释放,保证放热反应持续进行。进一步保证暖宫贴的持续作用时间和使用质量。
附图说明:
附图1为本发明致力于原发性痛经中药暖宫贴的主视结构示意图。
附图2为本发明致力于原发性痛经中药暖宫贴的剖视结构示意图。
具体实施方式
下面结合实施例对本发明作进一步详细说明。
如图1图2所示:
实施例1
发热层3:
发热材料6各组分重量百分含量:
制备方法:
将发热材料6混合均匀后,填充在内包装袋中即可;
所述的内袋为无纺布;
所述的外袋为自粘性无纺布,为商业化产品;
所述的包装为塑料,如Kopp+铝膜+PE,具有良好的隔氧作用。
中药浸膏:附子40g、肉桂40g、川芎30g、防风40g、白芷40g、当归30g、五灵脂40g、独活40g、杜仲30g、木瓜40g
本实施例中暖宫贴的制备方法,步骤如下:
中药浸膏的制备方法:
(1)按照重量份分别称取附子、肉桂、川芎、木瓜、防风粉碎成粉末,过100目筛,得到粉末A,按照重量份分别称取当归饮片和杜仲饮片,分别粉碎过50目筛得粗粉B和粗粉C;
(2)将粗粉B用50%~95%乙醇浸渍24小时,以0.5~8ml/min速度渗漉得渗漉液D;
(3)将渗漉液D低温减压回收乙醇至尽,浓缩至相对密度0.8~1.3的浸膏;
(4)取粗粉至C适当容器中并加60%乙醇进行超声处理,过滤取滤液E;
(5)将滤液E低温减压回收乙醇至尽,浓缩至相对密度0.8~1.3的浸膏;
(6)按照重量份称取五灵脂和独活,粉碎,用8倍量水煎煮2小时,随后加6倍水煎煮1小时,合并煎液,滤过得滤液F;
(7)将滤液F减压浓缩至相对密度为0.8~1.3的浸膏;
(8)按照重量称取白芷饮片,用粉碎机粉碎后过50目筛,得白芷粉末,加入食用油进行浸提24h,过滤,得白芷提取物油液;
(9)将粉末A、步骤(3)、(5)、(7)中的浸膏和步骤(8)中的油提液混合得中药药膏。
进一步地,将步骤(9)中的药膏装入无纺布袋中,四周压制密封完整,即得载药层2。将载药层2与发热层3粘合,并在药包层的另一面贴上离型纸1,装入真空包装袋密封,即获得所述的致力于原发性痛经中药暖宫贴。
实施例2
发热层3:
发热材料6各组分重量百分含量:
其他同实施例1
中药浸膏:附子40g、肉桂40g、川芎50g、防风40g、白芷40g、当归50g、五灵脂40g、独活40g、杜仲50g、木瓜40g
本实施例中暖宫贴的制备方法,步骤如下:
中药浸膏的制备方法:
(1)按照重量份分别称取附子、肉桂、川芎、木瓜、防风粉碎成粉末,过100目筛,得到粉末A,按照重量份分别称取当归饮片和杜仲饮片,分别粉碎过50目筛得粗粉B和粗粉C;
(2)将粗粉B用50%~95%乙醇浸渍24小时,以0.5~8ml/min速度渗漉得渗漉液D;
(3)将渗漉液D低温减压回收乙醇至尽,浓缩至相对密度0.8~1.3的浸膏;
(4)取粗粉至C适当容器中并加60%乙醇进行超声处理,过滤取滤液E;
(5)将滤液E低温减压回收乙醇至尽,浓缩至相对密度0.8~1.3的浸膏;
(6)按照重量份称取五灵脂和独活,粉碎,用8倍量水煎煮2小时,随后加6倍水煎煮1小时,合并煎液,滤过得滤液F;
(7)将滤液F减压浓缩至相对密度为0.8~1.3的浸膏;
(8)按照重量称取白芷饮片,用粉碎机粉碎后过50目筛,得白芷粉末,加入食用油进行浸提24h,过滤,得白芷提取物油液;
(9)将粉末A、步骤(3)、(5)、(7)中的浸膏和步骤(8)中的油提液混合得中药药膏。
进一步地,将步骤(9)中的药膏装入无纺布袋中,四周压制密封完整,即得载药层2。将载药层2与发热层3粘合,并在药包层的另一面贴上离型纸1,装入真空包装袋密封,即获得所述的致力于原发性痛经中药暖宫贴。
实施例3
发热层3:
发热材料6各组分重量百分含量:
其他同实施例1
中药浸膏:附子40g、肉桂40g、川芎40g、防风40g、白芷40g、当归40g、五灵脂40g、独活40g、杜仲40g、木瓜40g
本实施例中暖宫贴的制备方法,步骤如下:
中药浸膏的制备方法:
(1)按照重量份分别称取附子、肉桂、川芎、木瓜、防风粉碎成粉末,过100目筛,得到粉末A,按照重量份分别称取当归饮片和杜仲饮片,分别粉碎过50目筛得粗粉B和粗粉C;
(2)将粗粉B用50%~95%乙醇浸渍24小时,以0.5~8ml/min速度渗漉得渗漉液D;
(3)将渗漉液D低温减压回收乙醇至尽,浓缩至相对密度0.8~1.3的浸膏;
(4)取粗粉至C适当容器中并加60%乙醇进行超声处理,过滤取滤液E;
(5)将滤液E低温减压回收乙醇至尽,浓缩至相对密度0.8~1.3的浸膏;
(6)按照重量份称取五灵脂和独活,粉碎,用8倍量水煎煮2小时,随后加6倍水煎煮1小时,合并煎液,滤过得滤液F;
(7)将滤液F减压浓缩至相对密度为0.8~1.3的浸膏;
(8)按照重量称取白芷饮片,用粉碎机粉碎后过50目筛,得白芷粉末,加入食用油进行浸提24h,过滤,得白芷提取物油液;
(9)将粉末A、步骤(3)、(5)、(7)中的浸膏和步骤(8)中的油提液混合得中药药膏。
进一步地,将步骤(9)中的药膏装入无纺布袋中,四周压制密封完整,即得载药层2。将载药层2与发热层3粘合,并在药包层的另一面贴上离型纸1,装入真空包装袋密封,即获得所述的致力于原发性痛经中药暖宫贴。
Claims (10)
1.一种致力于原发性痛经中药暖宫贴,其特征在于,包括依次叠加设置的离型纸(1)、载药层(2)、发热层(3)和无纺布层(4);所述载药层(2)包括无纺布内袋和填充在内袋中的药物(5),所述的发热层(3)包括内袋和填充在内袋中的发热材料(6);(8)为压敏胶用于贴敷于皮肤。
所述的载药层(2)与发热层(3)相互复合,采用粘合剂(7)粘合或缝合的方法,用外袋包裹在载药层(2)和发热层(3)外,并用包装包裹在外袋之外。
2.根据权利要求1所述的一种致力于原发性痛经中药暖宫贴,其特征在于,所述载药层(2)用于装载药物,包括附子、肉桂、川芎、防风、白芷、当归、五灵脂、独活、杜仲、木瓜;
配比为:附子30~50g、肉桂30~50g、川芎30~50g、防风30~50g、白芷30~50g、当归30~50g、五灵脂30~50g、独活30~50g、杜仲30~50g、木瓜30~50g。
4.根据权利要求1所述的一种致力于原发性痛经中药暖宫贴,其特征在于,所述内袋为无纺布;
所述的外袋为自粘性无纺布,为商业化产品;
所述的包装为塑料,如Kopp+铝膜+PE,具有良好的隔氧作用。
5.根据权利要求1所述的一种致力于原发性痛经中药暖宫贴,其特征在于,所述的发热层(3)制备方法为常规的,将发热材料(6)的各个组分混合均匀后填充在内袋中即可。
6.基于权利要求1-5任一项所述的一种致力于原发性痛经中药暖宫贴的制备方法,其特征在于,包括以下步骤;
(1)按重量分别称取附子、肉桂、川芎、木瓜、防风,用粉碎机粉碎后过100目筛,各个药粉分别留用;
(2)按重量称取白芷饮片,用粉碎机粉碎后过50~100目筛,得白芷粉末,加入食用油进行浸提24h,过滤,得白芷提取物油液;
(3)按重量称取当归饮片,用粉碎机粉碎后过50~100目筛,得当归粉末,加入50~95%乙醇浸渍24h,以渗漉方式低温减压回收乙醇至尽,浓缩得到浸膏;按重量称取五灵脂、独活,分别加入8倍量水煎煮2h,随后加6倍量水煎煮1h,合并两次煎液,过滤,减压浓缩得到浸膏;按重量称取杜仲饮片,用粉碎机粉碎后过50~100目筛,得杜仲粉末,加入60%乙醇,超声提取,回收乙醇至尽,减压浓缩得到浸膏;
(4)将步骤(1)中所得的中药粉末和步骤(3)中所得的各浸膏按一定比例加入步骤(2)白芷提取物油液中,搅拌混合均匀,得到中药药膏;
(5)将步骤(4)中的药膏装入无纺布袋中,四周压制密封完整,得到载药层(2);
(6)将制备的载药层(2)粘和在发热层(3)上,并在载药层(2)的另一面贴上离型纸(1),装入真空包装袋密封,即获得原发性痛经中药暖宫贴。
7.根据权利要求6所述的一种致力于原发性痛经中药暖宫贴的制备方法,其特征在于,所述无纺布袋采用无纺布制作,将发热填充物装入无纺布袋中,四周压制密封完整。
8.根据权利要求6所述的一种致力于原发性痛经中药暖宫贴的制备方法,其特征在于,所述步骤(1)所述的食用油的量为白芷细粉重量的5~15倍;
所述步骤(1)渗漉速度为0.5~8ml/min。
9.根据权利要求6所述的一种致力于原发性痛经中药暖宫贴的制备方法,其特征在于,所述步骤(1)所述的浓缩浸膏相对密度为0.8~1.30(60℃)。
10.根据权利要求6所述的一种致力于原发性痛经中药暖宫贴的制备方法,其特征在于,所述步骤(3)超声条件是200Mpa,200Hz,50℃。
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