CN114788804B - Moisturizing double-layer water and preparation method thereof - Google Patents
Moisturizing double-layer water and preparation method thereof Download PDFInfo
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- CN114788804B CN114788804B CN202110624731.3A CN202110624731A CN114788804B CN 114788804 B CN114788804 B CN 114788804B CN 202110624731 A CN202110624731 A CN 202110624731A CN 114788804 B CN114788804 B CN 114788804B
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 61
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 25
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 25
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 25
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 20
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 17
- 239000000419 plant extract Substances 0.000 claims abstract description 14
- 239000008158 vegetable oil Substances 0.000 claims abstract description 14
- 229920000098 polyolefin Polymers 0.000 claims abstract description 13
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 150000001335 aliphatic alkanes Chemical class 0.000 claims abstract description 9
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229940097043 glucuronic acid Drugs 0.000 claims abstract description 8
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 8
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims description 31
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 22
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 22
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- 125000005456 glyceride group Chemical group 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 17
- 238000003756 stirring Methods 0.000 claims description 17
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 229920006007 hydrogenated polyisobutylene Polymers 0.000 claims description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- -1 small-molecule polyol Chemical class 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 8
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 7
- 229940071160 cocoate Drugs 0.000 claims description 7
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 7
- 235000004433 Simmondsia californica Nutrition 0.000 claims description 6
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims description 6
- 239000003921 oil Substances 0.000 claims description 6
- 235000019198 oils Nutrition 0.000 claims description 6
- 229920005862 polyol Polymers 0.000 claims description 6
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 5
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 claims description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 5
- 229920006037 cross link polymer Polymers 0.000 claims description 5
- 229940014041 hyaluronate Drugs 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 229910052700 potassium Inorganic materials 0.000 claims description 5
- 239000011591 potassium Substances 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 235000019489 Almond oil Nutrition 0.000 claims description 3
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 3
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 3
- 239000008168 almond oil Substances 0.000 claims description 3
- 239000010495 camellia oil Substances 0.000 claims description 3
- 239000004006 olive oil Substances 0.000 claims description 3
- 235000008390 olive oil Nutrition 0.000 claims description 3
- 229940057910 shea butter Drugs 0.000 claims description 3
- 244000044822 Simmondsia californica Species 0.000 claims 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims 1
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 25
- 229940064064 purslane extract Drugs 0.000 description 10
- 229920000642 polymer Polymers 0.000 description 9
- 230000014759 maintenance of location Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 6
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 6
- 241000221095 Simmondsia Species 0.000 description 5
- 239000000178 monomer Substances 0.000 description 5
- 229940015975 1,2-hexanediol Drugs 0.000 description 4
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
- 235000019438 castor oil Nutrition 0.000 description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 239000004166 Lanolin Substances 0.000 description 3
- 229940069521 aloe extract Drugs 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 229940039717 lanolin Drugs 0.000 description 3
- 235000019388 lanolin Nutrition 0.000 description 3
- 150000003384 small molecules Chemical class 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229940083542 sodium Drugs 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 229940043375 1,5-pentanediol Drugs 0.000 description 2
- 241000208680 Hamamelis mollis Species 0.000 description 2
- 235000004347 Perilla Nutrition 0.000 description 2
- 244000124853 Perilla frutescens Species 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 229940059958 centella asiatica extract Drugs 0.000 description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229940051250 hexylene glycol Drugs 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 230000000379 polymerizing effect Effects 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000005808 skin problem Effects 0.000 description 2
- 239000001570 sorbitan monopalmitate Substances 0.000 description 2
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 2
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 2
- 229920001897 terpolymer Polymers 0.000 description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 2
- 229940118846 witch hazel Drugs 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 1
- 244000234609 Portulaca oleracea Species 0.000 description 1
- 235000001855 Portulaca oleracea Nutrition 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
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- 229960002446 octanoic acid Drugs 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
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- 210000000434 stratum corneum Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of cosmetics, in particular to high-efficiency moisturizing double-layer water and a preparation method thereof. The raw materials comprise, by weight: phase A: 0.01-0.5% of glucuronic acid, and the balance of water; and B phase: 0.1-8% of emulsifying agent, 1-10% of C15-19 alkane, 1-10% of hydrogenated polyolefin and 1-7% of vegetable oil; and C phase: 1-10% of small molecular polyalcohol and 0.2-0.6% of p-hydroxyacetophenone; and D phase: 0.001-5% of plant extract; hyaluronic acid and derivatives thereof 0.001-2%; e phase: 0.001-0.5% of essence. The invention has excellent vision and outstanding skin care effect, the skin moisture content is increased by more than 10% after 3 hours of use compared with that before use, the product has strong stability, wide temperature resistance and good broad-spectrum antibacterial property, and the content of harmful substances meets the industry standard, thereby being suitable for wide popularization in the field of cosmetics.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to high-efficiency moisturizing double-layer water and a preparation method thereof.
Background
Along with the rapid development of national industry and economy, the life rhythm of modern people is faster and faster, and the face skin is directly exposed to the air, so that the pressure born by the face skin is bigger and bigger. The moisture in the outdoor air is obviously reduced due to the fact that the climate is warmed and dust is frequently generated, and the moisture in the skin is silently lost due to the long-term operation of the indoor air conditioner and the electronic products. The skin metabolism speed is slowed down due to the decrease of skin moisture, and pores are easily blocked by daily makeup of people, so that the skin state of consumers is difficult to keep at a normal level, various skin problems (such as dryness, blackheads, acne, large pores and the like) cause physical and psychological damage to consumers, and the key measure for improving the skin problems is to supplement water to the skin, various physiological functions of the skin can be refreshed after the water is sufficiently supplied, and the skin can return to elasticity and water tenderness. In this context, moisturizing the skin is the basic function that existing skin care products should possess.
In the prior art, various functional raw materials are usually added into the skin care product to achieve various skin care effects, but the formed mixed system is sensitive to environmental changes, particularly the shape difference easily occurs under low temperature and high temperature changes, and the efficacy exertion of the skin care product is further limited. Based on the above, the preparation of a skin care product with high efficiency, moisture retention and strong stability becomes a problem to be solved in the field.
Disclosure of Invention
The invention solves the problems of serious skin water shortage and poor skin care product stability in the prior art by providing the high-efficiency moisturizing double-layer water, and realizes the high-efficiency moisturizing skin care product with high stability.
The first aspect of the invention provides high-efficiency moisturizing double-layer water, which comprises the following raw materials in percentage by weight:
phase A: 0.01-0.5% of glucuronic acid, and the balance of water;
and B phase: 0.1-8% of emulsifying agent, 1-10% of C15-19 alkane, 1-10% of hydrogenated polyolefin and 1-7% of vegetable oil;
and C phase: 1-10% of small molecular polyalcohol and 0.2-0.6% of p-hydroxyacetophenone;
and D phase: 0.001-5% of plant extract; hyaluronic acid and derivatives thereof 0.001-2%;
e phase: 0.001-0.5% of essence;
wherein the weight ratio of the phase A, the phase B, the phase C and the phase D to the phase E is 100 percent.
In a preferred embodiment, the emulsifier comprises at least one of glycerides, higher alcohol sulfate, triethanolamine, cetostearyl alcohol, tween, lanolin, sorbitan monopalmitate.
In a preferred embodiment, the emulsifier is a glyceride and higher alcohol sulfate in a weight ratio of 1: (0.2-2).
In a preferred embodiment, the hydrogenated polyolefin comprises hydrogenated polyisobutene and/or hydrogenated polydecene.
In a preferred embodiment, the vegetable oil comprises at least one of olive oil, jojoba seed oil, shea butter, tea seed oil, almond oil.
In a preferred embodiment, the small molecule polyol comprises at least one of ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol.
In a preferred embodiment, the plant extract comprises at least one of aloe extract, witch hazel extract, purslane extract, centella asiatica extract, perilla leaf extract.
In a preferred embodiment, the hyaluronic acid and its derivatives include at least one of sodium hyaluronate, hydroxypropyl trimethylammonium chloride hyaluronic acid, hydrolyzed hyaluronic acid, acetylated sodium hyaluronate, hyaluronic acid, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate, potassium hyaluronate.
In a preferred embodiment, the emulsifier, C15-19 alkane, small molecule polyol is present in a weight ratio of (1-6): (3-10): (2-8): (1-5).
The second aspect of the invention provides a preparation method of high-efficiency moisturizing double-layer water, which comprises the following specific preparation steps:
s1, weighing a phase A material according to the formula amount, adding the material into a water phase pot, uniformly stirring, and heating to 80-85 ℃ to obtain a mixture I;
s2, weighing the phase B material according to the formula amount, adding the phase B material into an oil phase pot, uniformly stirring, and heating to 75-80 ℃ to obtain a mixture II;
s3, pouring the second mixture into the first mixture, uniformly stirring, homogenizing, and cooling to obtain a third mixture;
s4, adding the C phase, the D phase and the E phase raw materials into the mixture III, uniformly stirring, filtering and discharging.
The beneficial effects are that:
the invention provides high-efficiency moisturizing double-layer water, which has the advantages that compared with the prior art, the invention has the following advantages: the aqueous agent can be stably presented in two different appearance forms, so that excellent visual and superior skin care effects are obtained, skin care and visual experience are organically combined, beauty and sense are combined, and comfortable skin care experience is brought to a user. The double-layer water has excellent moisturizing effect, the skin moisture content is still increased by more than 10% after being used for 3 hours compared with that before being used, the product has strong stability and wide temperature resistance, has good broad-spectrum antibacterial property, and the content of harmful substances meets the industry standard, so that the double-layer water is suitable for being widely popularized in the field of cosmetics.
Detailed Description
The contents of the present invention can be more easily understood by referring to the following detailed description of preferred embodiments of the present invention and examples included. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprising," "including," "having," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, step, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, step, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified element, step or component. If used in a claim, such phrase will cause the claim to be closed, such that it does not include materials other than those described, except for conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the claim body, rather than immediately following the subject, it is limited to only the elements described in that clause; other elements are not excluded from the stated claims as a whole.
When an equivalent, concentration, or other value or parameter is expressed as a range, preferred range, or a range bounded by a list of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when ranges of "1 to 5" are disclosed, the described ranges should be construed to include ranges of "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a numerical range is described herein, unless otherwise indicated, the range is intended to include its endpoints and all integers and fractions within the range.
The singular forms include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or event may or may not occur, and that the description includes both cases where the event occurs and cases where the event does not.
Approximating language, in the specification and claims, may be applied to modify an amount that would not limit the invention to the specific amount, but would include an acceptable portion that would be close to the amount without resulting in a change in the basic function involved. Accordingly, the modification of a numerical value with "about", "about" or the like means that the present invention is not limited to the precise numerical value. In some examples, the approximating language may correspond to the precision of an instrument for measuring the value. In the present specification and claims, the range limitations may be combined and/or interchanged, such ranges including all the sub-ranges contained therein if not expressly stated.
Furthermore, the indefinite articles "a" and "an" preceding an element or component of the invention are not limited to the requirements of the number of elements or components (i.e. the number of occurrences). Thus, the use of "a" or "an" should be interpreted as including one or at least one, and the singular reference of an element or component also includes the plural reference unless the amount is obvious to the singular reference.
"Polymer" means a polymeric compound prepared by polymerizing monomers of the same or different types. The generic term "polymer" encompasses the terms "homopolymer", "copolymer", "terpolymer" and "interpolymer". "interpolymer" means a polymer prepared by the polymerization of at least two different monomers. The generic term "interpolymer" includes the term "copolymer" (which is typically employed to refer to polymers prepared from two different monomers) and the term "terpolymer" (which is typically employed to refer to polymers prepared from three different monomers). It also includes polymers made by polymerizing more monomers. "blend" means a polymer formed by the co-mixing of two or more polymers by physical or chemical means.
In order to solve the problems, the first aspect of the invention provides high-efficiency moisturizing double-layer water, which comprises the following raw materials in percentage by weight:
phase A: 0.01-0.5% of glucuronic acid, and the balance of water;
and B phase: 0.1-8% of emulsifying agent, 1-10% of C15-19 alkane, 1-7% of hydrogenated polyolefin and vegetable oil;
and C phase: 1-10% of small molecular polyalcohol and 0.2-0.6% of p-hydroxyacetophenone;
and D phase: 0.001-5% of plant extract; hyaluronic acid and derivatives thereof 0.001-2%;
e phase: 0.001-0.5% of essence;
wherein the weight ratio of the phase A, the phase B, the phase C and the phase D to the phase E is 100 percent.
Examples of glucuronic acid include, but are not limited to, sodium hyaluronate.
In some preferred embodiments, the emulsifier comprises at least one of glycerides, higher alcohol sulfate, triethanolamine, cetostearyl alcohol, tween, lanolin, sorbitan monopalmitate.
In some preferred embodiments, the emulsifier is a glyceride and higher alcohol sulfate salt in a weight ratio of 1: (0.2-2).
Examples of higher alcohol sulfate salts include, but are not limited to, sodium coco polyether sulfate.
Further preferably, the glyceride comprises PEG-40 glycerol cocoate and PEG-6 caprylic/capric glyceride, and the weight ratio of the PEG-40 glycerol cocoate to the PEG-6 caprylic/capric glyceride is (1-3): 1.
in some preferred embodiments, the hydrogenated polyolefin comprises hydrogenated polyisobutene and/or hydrogenated polydecene.
Further preferred, the hydrogenated polyolefin comprises hydrogenated polyisobutene and hydrogenated polydecene; the weight ratio of hydrogenated polyisobutene to hydrogenated polydecene is (0.6-1.5): 1.
in some preferred embodiments, the vegetable oil comprises at least one of olive oil, jojoba seed oil, shea butter, tea seed oil, almond oil.
Further preferably, the vegetable oil is jojoba seed oil.
In some preferred embodiments, the small molecule polyol comprises at least one of ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol.
Further preferably, the small molecule polyols are butanediol and 1, 2-hexanediol; the weight ratio of the butanediol to the 1, 2-hexanediol is (1-10): (0.2-0.8).
In some preferred embodiments, the plant extract comprises at least one of aloe extract, witch hazel extract, purslane extract, centella asiatica extract, perilla leaf extract.
Further preferably, the plant extract is a purslane extract; still more preferably, the purslane extract is pre-dissolved before being added, and the pre-dissolution operation is that the purslane extract is added into a mixture of butanediol and water and stirred uniformly; the weight ratio of the purslane extract, the butanediol and the water is (2-5): 1:1.
in some preferred embodiments, the hyaluronic acid and derivatives thereof comprise at least one of sodium hyaluronate, hydroxypropyl trimethylammonium chloride hyaluronic acid, hydrolyzed hyaluronic acid, acetylated sodium hyaluronate, hyaluronic acid, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate, potassium hyaluronate.
In some preferred embodiments, the emulsifier, C15-19 alkane, small molecule polyol weight ratio is (1-6): (3-10): (2-8): (1-5).
In some preferred embodiments, the perfume is pre-dissolved prior to addition, the pre-dissolution operation being that the perfume is added to the mixture of hydrogenated castor oil and water and stirred well; the weight ratio of the hydrogenated castor oil to the water is (1-4): (0.5-2): 1.
according to the invention, PEG-40 glycerol cocoate, PEG-6 caprylic/capric acid glyceride and sodium cocopolyether sulfate are selected as emulsifying agents, and are combined with a specific amount of hydrogenated polyolefin, vegetable oil and plant extract to achieve the effect of improving the moisturizing effect of double-layer water; it has further been found that when hydrogenated polyolefin selectively hydrogenated polyisobutene and hydrogenated polydecene are co-acted, the oil phase and water phase molecules in the system can be stabilized to form an electric double layer; when the weight ratio of hydrogenated polyisobutene to hydrogenated polydecene is (0.6-1.5): 1, the thermal stability of double-layer water is obviously improved, and the problem of oil-water layer infiltration can not occur when the double-layer water is placed for 24 hours at 40+/-1 ℃. The invention further researches and discovers that when the vegetable oil is jojoba seed oil and the plant extract is purslane extract, the moisturizing effect of the double-layer water can reach more than 10%, and meanwhile, the oil phase of the double-layer water is stabilized above the water layer, so that the appearance is beautiful and the visual effect is good; and after long-term use, the skin is obviously elastic, the stratum corneum is softened, the skin is transparent and glossy, and the skin care experience is excellent.
The second aspect of the invention provides a preparation method of high-efficiency moisturizing double-layer water, which comprises the following specific preparation steps:
s1, weighing a phase A material according to the formula amount, adding the material into a water phase pot, uniformly stirring, and heating to 80-85 ℃ to obtain a mixture I;
s2, weighing the phase B material according to the formula amount, adding the phase B material into an oil phase pot, uniformly stirring, and heating to 75-80 ℃ to obtain a mixture II;
s3, pouring the second mixture into the first mixture, uniformly stirring, homogenizing, and cooling to obtain a third mixture;
s4, adding the C phase, the D phase and the E phase raw materials into the mixture III, uniformly stirring, filtering and discharging.
Examples
In order to better understand the above technical solution, the following describes the above technical solution in detail with reference to specific embodiments. It is noted herein that the following examples are given solely for the purpose of further illustration and are not to be construed as limitations on the scope of the invention, as will be apparent to those skilled in the art in light of the foregoing disclosure. In addition, the raw materials used are commercially available, and the extraction methods of the extracts are conventional extraction methods, unless otherwise specified.
Example 1.
The embodiment provides high-efficiency moisturizing double-layer water, which comprises the following raw materials:
phase A: 0.2% of glucuronic acid and the balance of water;
and B phase: 4% of emulsifying agent, 4% of C15-19 alkane, 8% of hydrogenated polyolefin and 3% of vegetable oil;
and C phase: 7% of small-molecule polyalcohol and 0.4% of p-hydroxyacetophenone;
and D phase: 4% of a plant extract; hyaluronic acid and its derivative 1%;
e phase: 0.5% of essence;
wherein the weight ratio of the phase A, the phase B, the phase C and the phase D to the phase E is 100 percent.
The glucuronic acid is sodium hyaluronate.
The emulsifier is glyceride and higher alcohol sulfate, and the weight ratio of the glyceride to the higher alcohol sulfate is 1:0.5.
the higher alcohol sulfate is sodium coco alcohol polyether sulfate;
the glyceride is PEG-40 glycerol cocoate and PEG-6 caprylic acid/capric acid glyceride; the weight ratio of PEG-40 glycerol cocoate to PEG-6 caprylic/capric glyceride is 2:1.
the hydrogenated polyolefin includes hydrogenated polyisobutene and hydrogenated polydecene; the weight ratio of hydrogenated polyisobutene to hydrogenated polydecene was 1.4:1.
the vegetable oil is jojoba seed oil, and is purchased from Shanghai Xin Biotechnology Co.
The small molecule polyalcohol is 1, 3-butanediol and 1, 2-hexanediol; the weight ratio of the 1, 3-butanediol to the 1, 2-hexanediol is 8:0.6.
the plant extract is purslane extract (latin academy: portulaca oleracea l.); pre-dissolving herba Portulacae extract before adding, wherein the pre-dissolving operation comprises adding herba Portulacae extract into the mixture of butanediol and water, and stirring; the weight ratio of the purslane extract, butanediol and water is 4:1:1. purslane extract was purchased from finesse biosciences, inc.
The hyaluronic acid and the derivatives thereof comprise sodium hyaluronate, hydroxypropyl trimethyl ammonium chloride hyaluronic acid, hydrolyzed hyaluronic acid, acetylated sodium hyaluronate, hyaluronic acid, sodium hyaluronate crosslinked polymer, hydrolyzed sodium hyaluronate and potassium hyaluronate; sodium hyaluronate, hydroxypropyl trimethyl ammonium chloride hyaluronic acid, hydrolyzed hyaluronic acid, acetylated sodium hyaluronate, hyaluronic acid, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate and potassium hyaluronate in a weight ratio of 3:0.5:1:1:2:1:0.8:2.
the essence is pre-dissolved before being added, and the pre-dissolution operation is that the essence is added into a mixture of hydrogenated castor oil and water and is uniformly stirred; the weight ratio of hydrogenated castor oil to water is 3:1:1. the essence is purchased from Jinan Dairy melting company, inc., model number LDY544.
The second aspect of the present embodiment provides a preparation method of high-efficiency moisturizing double-layer water, which specifically includes the steps of:
s1, weighing a phase A material according to the formula amount, adding the material into a water phase pot, uniformly stirring, and heating to 82 ℃ to obtain a mixture I;
s2, weighing the phase B material according to the formula amount, adding the phase B material into an oil phase pot, uniformly stirring, and heating to 78 ℃ to obtain a mixture II;
s3, pouring the second mixture into the first mixture, uniformly stirring, homogenizing, and cooling to obtain a third mixture;
s4, adding the C phase, the D phase and the E phase raw materials into the mixture III, uniformly stirring, filtering with 200 meshes, and discharging.
Example 2.
The embodiment provides double-layer water with high efficiency and moisture retention, and the specific embodiment is the same as the embodiment 1; the difference is that the raw materials comprise:
phase A: 0.3% of glucuronic acid and the balance of water;
and B phase: 5% of emulsifying agent, 7% of C15-19 alkane, 6% of hydrogenated polyolefin and 4% of vegetable oil;
and C phase: 7% of small-molecule polyalcohol and 0.4% of p-hydroxyacetophenone;
and D phase: 3% of plant extract; hyaluronic acid and its derivative 1%;
e phase: 0.5% of essence;
wherein the weight ratio of the phase A, the phase B, the phase C and the phase D to the phase E is 100 percent.
Example 3.
The embodiment provides double-layer water with high efficiency and moisture retention, and the specific embodiment is the same as the embodiment 1; the difference is that the weight ratio of glyceride to higher alcohol sulfate is 1:1.
example 4.
The embodiment provides double-layer water with high efficiency and moisture retention, and the specific embodiment is the same as the embodiment 1; the difference is that the weight ratio of glyceride to higher alcohol sulfate is 1:5.
example 5.
The embodiment provides double-layer water with high efficiency and moisture retention, and the specific embodiment is the same as the embodiment 1; except that the emulsifier is lanolin.
Example 6.
The embodiment provides double-layer water with high efficiency and moisture retention, and the specific embodiment is the same as the embodiment 1; except that the plant extract was Aloe extract (academic name: aloe vera (haw.) Berg), purchased from Shaanxi Bai Cuikang Biotech Co.
Example 7.
The embodiment provides double-layer water with high efficiency and moisture retention, and the specific embodiment is the same as the embodiment 1; except that no vegetable oil was added.
Example 8.
The embodiment provides double-layer water with high efficiency and moisture retention, and the specific embodiment is the same as the embodiment 1; except that hydrogenated polydecene was not added.
Performance test method
The water supplementing effect is as follows:
randomly forming 70 volunteer groups (10 groups, 7 groups), wherein each group of volunteers uses the high-efficiency moisturizing double-layer water prepared in the examples 1-7 by taking 3mL of double-layer water to be smeared on the back of the hand; the water content of the back of the hand before and after 3 hours of use is tested, and the change rate delta of the water content of the back of the hand after 3 hours is calculated. The water content test instrument was realbibeeh 821.
Stability:
the high-efficiency moisturizing double-layer prepared in examples 1-7 are respectively placed at 40+/-1 ℃ and 5+/-1 ℃ for heat resistance and cold resistance testing, and each group of samples is divided into 10 parallel samples; the test time was 24h. Recording the number n of parallel samples with mixed or discolored oil-water layers after 24 hours; n=1 is defined as good, n is 1-3, and n is 4-4.
Performance test data
Finally, it is pointed out that the foregoing examples are illustrative only and serve to explain some of the features of the method according to the invention. The appended claims are intended to claim the broadest possible scope and the embodiments presented herein are merely illustrative of selected implementations based on combinations of all possible embodiments. It is, therefore, not the intention of the applicant that the appended claims be limited by the choice of examples illustrating the features of the invention. Some numerical ranges used in the claims also include sub-ranges within which variations in these ranges should also be construed as being covered by the appended claims where possible.
Claims (3)
1. The high-efficiency moisturizing double-layer water is characterized by comprising the following raw materials in percentage by weight:
phase A: 0.01-0.5% of glucuronic acid, and the balance of water;
and B phase: 0.1-8% of emulsifying agent, 1-10% of C15-19 alkane, 1-10% of hydrogenated polyolefin and 1-7% of vegetable oil;
and C phase: 1-10% of small molecular polyalcohol and 0.2-0.6% of p-hydroxyacetophenone;
and D phase: 0.001-5% of plant extract; hyaluronic acid and derivatives thereof 0.001-2%;
e phase: 0.001-0.5% of essence;
the emulsifier is glyceride and higher alcohol sulfate, and the weight ratio of the glyceride to the higher alcohol sulfate is 1: (0.2-2);
the glyceride comprises PEG-40 glycerol cocoate and PEG-6 caprylic/capric glyceride, wherein the weight ratio of the PEG-40 glycerol cocoate to the PEG-6 caprylic/capric glyceride is (1-3): 1, a step of;
the hydrogenated polyolefin includes hydrogenated polyisobutene and hydrogenated polydecene; the weight ratio of hydrogenated polyisobutene to hydrogenated polydecene is (0.6-1.5): 1, a step of;
the vegetable oil comprises at least one of olive oil, jojoba seed oil, shea butter, tea seed oil and almond oil; the plant extract is herba Portulacae extract;
the small molecular polyalcohol comprises at least one of ethylene glycol, propylene glycol, butanediol, pentanediol and hexanediol;
the hyaluronic acid and the derivatives thereof comprise at least one of sodium hyaluronate, hydroxypropyl trimethyl ammonium chloride hyaluronic acid, hydrolyzed hyaluronic acid, acetylated sodium hyaluronate, hyaluronic acid, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate and potassium hyaluronate.
2. The high-efficiency moisturizing double-layer water according to claim 1, wherein the weight ratio of the emulsifier to the C15-19 alkane to the small-molecule polyol is (1-6): (3-10): (2-8): (1-5).
3. A method for preparing the high-efficiency moisturizing double-layer water according to any one of claims 1 to 2, wherein the specific preparation steps comprise:
s1, weighing a phase A material according to the formula amount, adding the material into a water phase pot, uniformly stirring, and heating to 80-85 ℃ to obtain a mixture I;
s2, weighing the phase B material according to the formula amount, adding the phase B material into an oil phase pot, uniformly stirring, and heating to 75-80 ℃ to obtain a mixture II;
s3, pouring the second mixture into the first mixture, uniformly stirring, homogenizing, and cooling to obtain a third mixture;
s4, adding the C phase, the D phase and the E phase raw materials into the mixture III, uniformly stirring, filtering and discharging.
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| KR101884411B1 (en) * | 2017-07-13 | 2018-08-02 | 주식회사 뷰티채널 | Functional cosmetic composition for brighting and moisturizing cream |
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