CN114763628A - Antiviral nanofiber and preparation method thereof - Google Patents
Antiviral nanofiber and preparation method thereof Download PDFInfo
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- CN114763628A CN114763628A CN202110041928.4A CN202110041928A CN114763628A CN 114763628 A CN114763628 A CN 114763628A CN 202110041928 A CN202110041928 A CN 202110041928A CN 114763628 A CN114763628 A CN 114763628A
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- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 47
- 239000002121 nanofiber Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 25
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 25
- 238000001914 filtration Methods 0.000 claims abstract description 15
- 238000009987 spinning Methods 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims abstract description 12
- 238000010041 electrostatic spinning Methods 0.000 claims abstract description 11
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 10
- 238000006243 chemical reaction Methods 0.000 claims abstract description 8
- 238000004132 cross linking Methods 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000010438 heat treatment Methods 0.000 claims abstract description 5
- 229920003169 water-soluble polymer Polymers 0.000 claims abstract description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 239000003431 cross linking reagent Substances 0.000 claims description 6
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 4
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical group [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 238000006136 alcoholysis reaction Methods 0.000 claims description 2
- 239000003443 antiviral agent Substances 0.000 claims description 2
- 238000001523 electrospinning Methods 0.000 claims description 2
- 238000006116 polymerization reaction Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract description 12
- 241000700605 Viruses Species 0.000 abstract description 10
- 239000000126 substance Substances 0.000 abstract description 9
- 239000000243 solution Substances 0.000 description 24
- 239000000463 material Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 6
- 238000011081 inoculation Methods 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 230000002155 anti-virotic effect Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010069767 H1N1 influenza Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000010485 coping Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
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- 239000000835 fiber Substances 0.000 description 1
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- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
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- 239000000543 intermediate Substances 0.000 description 1
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- 230000035699 permeability Effects 0.000 description 1
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- 229920001282 polysaccharide Polymers 0.000 description 1
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Classifications
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/44—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds
- D01F6/50—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds of polyalcohols, polyacetals or polyketals
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
- D01F1/103—Agents inhibiting growth of microorganisms
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4282—Addition polymers
- D04H1/4309—Polyvinyl alcohol
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/12—Aldehydes; Ketones
- D06M13/123—Polyaldehydes; Polyketones
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/16—Synthetic fibres, other than mineral fibres
- D06M2101/18—Synthetic fibres consisting of macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- D06M2101/24—Polymers or copolymers of alkenylalcohols or esters thereof; Polymers or copolymers of alkenylethers, acetals or ketones
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- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Dispersion Chemistry (AREA)
- Mechanical Engineering (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Artificial Filaments (AREA)
Abstract
The invention discloses an antiviral nanofiber and a preparation method thereof, wherein the antiviral nanofiber is a water-soluble polymer nanofiber loaded with an antiviral component, the antiviral component is a quaternary ammonium salt derivative, and the antiviral nanofiber is subjected to water-insoluble treatment; the preparation method comprises the following steps: (1) dispersing polyvinyl alcohol in water, and stirring and dissolving under a heating condition to obtain a polyvinyl alcohol solution; (2) adding an antiviral component into the polyvinyl alcohol solution, and uniformly stirring at room temperature to obtain a mixed spinning solution; (3) carrying out electrostatic spinning by using the mixed spinning solution to obtain the antiviral component-loaded nano-fiber; (4) and (4) carrying out water-insoluble treatment on the nanofiber obtained in the step (3) through a crosslinking reaction. The antiviral nanofiber can be used as a filtering layer of air filtering devices and equipment such as masks and air filters, and can efficiently adsorb and kill harmful substances such as viruses and bacteria in the air.
Description
Technical Field
The invention belongs to the field of materials, and particularly relates to an antiviral nanofiber and a preparation method thereof.
Background
The nanofibers can be used as air filtration materials, generally, the filtration efficiency of the filtration materials increases with the decrease of the diameter of the filtration fibers, and the nanomaterials prepared by the electrospinning technology are generally distributed in the diameter range from a few nanometers to hundreds of nanometers. The electrostatic spinning is one of the most effective modes for preparing the nanofiber material at present, and has the advantages of simple operation, short preparation flow, wide material selection and the like.
The existing air filtering material only filters harmful substances such as viruses, bacteria and the like in the air through the physical properties of the material, and has limited effect.
Disclosure of Invention
The invention aims to provide an antiviral nanofiber and a preparation method thereof, provides a filtering material capable of killing harmful substances such as viruses, bacteria and the like in the air by a chemical method, and provides a dual filtering mechanism guarantee.
In order to achieve the above object, the present invention provides an antiviral nanofiber, wherein the nanofiber is a water-soluble polymer nanofiber loaded with an antiviral component, and the antiviral component is a quaternary ammonium salt derivative; the antiviral nanofiber is subjected to water-insoluble treatment to enhance the durability as an air filter material.
As a preferred example, the nanofibers are spun from a water-soluble high polymer PVA.
As a specific example, the water-insoluble treatment is a crosslinking reaction.
The invention also provides a preparation method of the antiviral nanofiber, which is characterized by comprising the following steps:
(1) dispersing polyvinyl alcohol in water, and stirring and dissolving under a heating condition to obtain a polyvinyl alcohol solution;
(2) adding an antiviral component quaternary ammonium salt derivative into the polyvinyl alcohol solution, and uniformly stirring at room temperature to obtain a mixed spinning solution;
(3) Carrying out electrostatic spinning by using the mixed spinning solution to obtain the antiviral component loaded nanofiber;
(4) and (3) carrying out water-insoluble treatment on the nanofibers obtained in the step (3) through a crosslinking reaction.
Wherein, the polymerization degree of the polyvinyl alcohol in the step (1) is 1700-2200, and the alcoholysis degree is not less than 95 percent;
wherein, the concentration of the polyvinyl alcohol solution in the step (1) is 8-15 wt%;
wherein the mass fraction of the antiviral component in the solution in the step (2) is 1-20 wt%, and the stirring time is 3-5 h;
wherein the electrostatic spinning parameters in the step (3) are as follows: the electrostatic spinning applied voltage is 12-20KV, the receiving distance is 12-22cm, and the solution flow rate is 0.4-1.2 mL/h;
wherein the temperature conditions of the electrostatic spinning in the step (3) are as follows: 20-25 ℃ and relative humidity of 30-50%;
wherein, the cross-linking agent of the cross-linking reaction in the step (4) is glutaraldehyde, and the solvent is acetone or absolute ethyl alcohol.
As a specific example, the quaternary ammonium salt derivative is dodecyltrimethylammonium chloride.
The nano material prepared by electrostatic spinning generally has higher porosity and excellent air permeability, is very suitable for being used as an air filtering material, has the excellent characteristics of high porosity, large specific surface area and the like of nano fibers, can better exert the drug effect, carries the drug by the nano fibers, can avoid the drug burst release in the release process of the drug, and can continuously and efficiently provide the drug effect.
The antiviral nanofiber can be used as a filter layer of air filtering devices and equipment such as a mask, an air filter, a breathing machine and the like, can efficiently adsorb and kill harmful substances such as viruses, bacteria and the like in the air, and further improves the filtering effect of the mask on the harmful substances in the air.
The anti-virus component of the invention is quaternary ammonium salt derivative which is a broad-spectrum anti-virus bacteriostatic agent, and the anti-virus component can attack the envelope composed of protein and polysaccharide in the virus to denature the envelope, so that the RNA of the virus can be accelerated to degrade until the RNA is finally inactivated to realize the anti-virus; the bacteria killing bacteria also has the function of sterilization, and the sterilization mechanism of the bacteria killing bacteria mainly effectively attaches cations with the sterilization function to the surface of the bacteria, so that bioactive enzymes and metabolic intermediates in the bacteria overflow by destroying cell membranes of the bacteria, thereby achieving the functions of sterilization and bacteriostasis.
The quaternary ammonium salt derivative is a water-soluble substance, has better compatibility with a polyvinyl alcohol solution, and enables the quaternary ammonium salt component to be uniformly distributed on the antiviral nano-fiber, thereby achieving better and more stable antiviral and antibacterial effects and having better biological safety.
The nanofiber is mainly prepared by spinning the water-soluble high polymer PVA, the problem of solvent residue is avoided, the selected material is green and environment-friendly, and the nanofiber has stronger durability in coping with humidity in the air, moisture discharged by breathing and the like through water-insoluble treatment such as crosslinking reaction; the invention is environment-friendly and nontoxic, kills harmful substances such as viruses, bacteria and the like in the air by a chemical method and provides a dual filtering mechanism guarantee.
Detailed Description
The technical solutions of the present invention will be described clearly and completely below, and it should be apparent that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
Example one
(1) Adding 10g of polyvinyl alcohol into 80g of water, and stirring for 8 hours under the heating condition of 80 ℃ to dissolve the polyvinyl alcohol to obtain a polyvinyl alcohol solution;
(2) adding 10g of dodecyl trimethyl ammonium chloride into the polyvinyl alcohol solution, and uniformly stirring for 3 hours at room temperature to obtain a mixed spinning solution;
(3) and (2) carrying out electrostatic spinning on the mixed spinning solution to obtain the nanofiber membrane loaded with the antiviral component, wherein the spinning conditions are as follows: the spinning voltage is 15KV, the receiving distance is 12cm, and the solution flow rate is 0.8 ml/h;
(4) Preparing a cross-linking agent solution: adding 5 wt% of glutaraldehyde (25% aqueous solution) into acetone, then adding 2ml of dilute hydrochloric acid, and uniformly mixing;
(5) and (4) flatly immersing the nanofiber membrane prepared in the step (3) into the cross-linking agent solution in the step (4), standing for 3 hours, taking out, washing for 5 times, and drying in a drying oven at 40 ℃.
The prepared nanofiber membrane is tested for antiviral effect, and the experimental result is shown in table one, so that the antiviral activity rate of the antiviral nanofiber provided by the embodiment of the invention on H1N1 influenza virus reaches more than 91%.
Table one:
example two
(1) Adding 10g of polyvinyl alcohol into 70g of water, and stirring for 8 hours under the heating condition of 80 ℃ to dissolve the polyvinyl alcohol to obtain a polyvinyl alcohol solution;
(2) adding 20g of dodecyl trimethyl ammonium chloride into the polyvinyl alcohol solution, and uniformly stirring for 3 hours at room temperature to obtain a mixed spinning solution;
(3) and (2) carrying out electrostatic spinning on the mixed spinning solution to obtain the antiviral component-loaded nanofiber, wherein the spinning conditions are as follows: the spinning voltage is 15KV, the receiving distance is 12cm, and the solution flow rate is 0.8 ml/h;
(4) preparing a cross-linking agent solution: adding 5 wt% glutaraldehyde (25% water solution) into acetone, adding 2ml dilute hydrochloric acid, and mixing;
(5) and (4) flatly immersing the nano-fibers prepared in the step (3) into the cross-linking agent solution in the step (4), standing for 3 hours, taking out and washing for 5 times, and drying in a drying oven at 40 ℃.
The prepared nanofiber membrane is subjected to antiviral effect test, and the experimental result is shown in table two, so that the antiviral activity rate of the nanofiber membrane prepared in the embodiment of the invention on H3N2 influenza virus reaches more than 99%.
Table two:
the parameters in the tests in the two above-described examples are explained below:
a) and (3) testing result validity judgment standard: when the following given 3 conditions are all satisfied, the test is determined to be valid, otherwise, the test is invalid, and the test needs to be performed again.
1) The virus titer measured by immediate recovery of the control sample after inoculation should be 1.0X 106PFU/cm2(or TCID50/cm2) To 1.0X 107PFU/cm2(or TCID50/cm2) In the presence of a surfactant.
2) The eluent does achieve effective inhibition of the antiviral agent in the sample.
3) The control sample had a log reduction in viral titer of less than or equal to 1.0.
The calculation is shown in formula (1):
M＝lg(Va/Vb)＝lg(Va)-lg(Vb) …………………(1)
wherein
M is a decreasing value;
lg (va) is the log mean of viral infectious titers eluting immediately after inoculation of 3 reference samples;
lg (vb) is the log mean value of the virus infection titer eluted 2h after 3 reference samples are inoculated;
b) calculation of antiviral Activity value
The antiviral activity value was calculated using formula (2).
Mv＝lg(Va/Vc)＝lg(Va)-lg(Vc)………………………(2)
Wherein:
mv — antiviral activity value;
lg (Va) -3 control samples are inoculated for 2 hours and then the recovered virus titer is the mean value of the logarithm;
log mean of virus titers recovered 2h after inoculation of lg (Vc) -3 samples.
c) Calculation of antiviral Activity Rate
The antiviral activity rate was calculated using formula (3).
Wherein:
r (%) — antiviral activity (%);
b-average titer value recovered 0h after inoculation of 3 control samples, in units of PFU/cm2(or TCID50/cm2)；
C-average titer value recovered 2h after inoculation of 3 antiviral samples, in units of PFU/cm2(or TCID50/cm2)。
In summary, the above embodiments are merely preferred embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalents, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. An antiviral nanofiber, characterized in that the antiviral nanofiber is a water-soluble polymer nanofiber loaded with an antiviral component, and the antiviral component is a quaternary ammonium salt derivative; the antiviral nanofibers are treated to be water insoluble.
2. The anti-viral nanofiber according to claim 1, wherein the nanofiber is spun from a water-soluble high polymer PVA.
3. The production method according to claim 1, wherein the water-insoluble treatment is a crosslinking reaction.
4. A method for preparing the antiviral nanofiber as set forth in claim 1, comprising the steps of:
(1) dispersing polyvinyl alcohol in water, and stirring and dissolving under a heating condition to obtain a polyvinyl alcohol solution;
(2) adding an antiviral component quaternary ammonium salt derivative into the polyvinyl alcohol solution, and uniformly stirring at room temperature to obtain a mixed spinning solution;
(3) carrying out electrostatic spinning by using the mixed spinning solution to obtain the antiviral component loaded nanofiber;
(4) and (3) carrying out water-insoluble treatment on the nanofibers obtained in the step (3) through a crosslinking reaction.
5. The preparation method according to claim 4, wherein the polymerization degree of the polyvinyl alcohol in step (1) is 1700-2200, and the alcoholysis degree is 95% or more; the concentration of the polyvinyl alcohol solution is 8-15 wt%.
6. The method according to claim 4, wherein in the step (2), the quaternary ammonium salt derivative is dodecyltrimethylammonium chloride.
7. The preparation method according to claim 4, wherein the mass fraction of the antiviral agent in the solution in the step (2) is 1-20 wt%, and the stirring time is 3-5 h.
8. The method according to claim 4, wherein the parameters of the electrospinning in the step (3) are as follows: the electrostatic spinning applied voltage is 12-20KV, the receiving distance is 12-22cm, and the solution flow rate is 0.4-1.2 mL/h; the temperature is 20-25 deg.C, and the relative humidity is 30-50%.
9. The method according to claim 4, wherein the crosslinking agent in the crosslinking reaction in step (4) is glutaraldehyde, and the solvent is acetone or absolute ethanol.
10. Use of the antiviral nanofibers of claim 1 as a filtration layer in air filtration devices and equipment.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113638073A (en) * | 2021-07-22 | 2021-11-12 | 绍兴市柯桥区东纺纺织产业创新研究院 | Preparation method of antibacterial nanofiber |
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