CN114748778B - Transmission structure, liquid feeding device applying transmission structure and use method of liquid feeding device - Google Patents
Transmission structure, liquid feeding device applying transmission structure and use method of liquid feeding device Download PDFInfo
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- CN114748778B CN114748778B CN202110033302.9A CN202110033302A CN114748778B CN 114748778 B CN114748778 B CN 114748778B CN 202110033302 A CN202110033302 A CN 202110033302A CN 114748778 B CN114748778 B CN 114748778B
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- power transmission
- transmission structure
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- 230000005540 biological transmission Effects 0.000 title claims abstract description 64
- 239000007788 liquid Substances 0.000 title claims abstract description 54
- 238000000034 method Methods 0.000 title claims abstract description 9
- 230000007246 mechanism Effects 0.000 claims abstract description 34
- 229920001971 elastomer Polymers 0.000 claims abstract description 12
- 239000000806 elastomer Substances 0.000 claims abstract description 12
- 230000009471 action Effects 0.000 claims abstract description 7
- 238000006073 displacement reaction Methods 0.000 claims abstract description 4
- 238000012840 feeding operation Methods 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 1
- 210000001503 joint Anatomy 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 17
- 239000003814 drug Substances 0.000 description 7
- 238000013271 transdermal drug delivery Methods 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000037452 priming Effects 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 239000003961 penetration enhancing agent Substances 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 208000034693 Laceration Diseases 0.000 description 1
- 208000032370 Secondary transmission Diseases 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention provides a transmission structure, which comprises: first casing, cavity, first elastomer, second casing, power transmission mechanism, wherein: the front end of the second shell is sleeved with the first shell, a cavity is arranged in the first shell and is in butt joint with the first shell through a first elastomer, the rear end of the second shell is provided with a second elastomer, displacement is generated when the first shell is acted by external force, the cavity is in contact with the power transmission mechanism, and the cavity is controlled to reciprocate in set amplitude through the second elastomer and the first elastomer. The invention also provides a liquid feeding device and a liquid feeding using method, and solves the problems that when the non-contact action part of the cavity body is not pressed, liquid is not thrown out due to vibration, and the end part of the cavity body does not scratch the action part when the transmission structure slides on the stress surface.
Description
Technical Field
The invention relates to the technical field of priming devices, in particular to a transmission structure, a priming device applying the transmission structure and a use method of the priming device.
Background
At present, in the technical field of transdermal drug delivery, a micro device is widely applied, the surface of the micro device is provided with a series of micro needle arrays, radio frequency lattices, microelectrodes, lasers and the like, and the micro device can open the outermost stratum corneum of the skin, can not hurt the dermis layer, and greatly improves the nutrient permeability. By matching with the vibration introduction of the permeation enhancer, thousands of micro-pore channels can be opened on the surface of the skin in a short time, and the absorption of external medicines and skin care products can be greatly promoted. However, when the cavity body in the conventional permeation enhancer and the vibration component of the micro device are used, the device is opened without vibration, and the micro device is pressed on the skin to start vibration after the vibration component is stressed to contact with the internal transmission part of the device, so that the operation can only be carried out along the vibration direction of the wafer during the operation, and the continuous sliding operation can not be performed, because the skin can be scratched during the sliding operation, the requirements of users are not met no matter the use efficiency, the customer experience degree or the uniformity of transdermal drug delivery.
Through retrieving, patent document CN209303015U discloses a microneedle medicine guide mechanism of a beauty instrument, which comprises a catheter and a microneedle array chip arranged at the bottom of the catheter, wherein the top end of the catheter is communicated with an acoustic vibration generator, a plurality of microneedles are arranged on the microneedle array chip, a liquid guide port communicated with the catheter is formed at the tip of each microneedle, a reset spring and a guide protective sleeve are sequentially sleeved outside the catheter, the catheter is movably arranged in the guide protective sleeve in a penetrating manner, an upper step and a lower step are respectively arranged on the outer wall of the catheter and the inner wall of the guide protective sleeve, and two ends of the reset spring respectively offset with the upper step and the lower step. The disadvantage of this prior art is that only spot lifting operations are still possible, which still lead to problems of insufficient use efficiency and skin laceration if sliding transdermal drug delivery is performed.
Through retrieval, patent document CN205339844U discloses a device for facial care, which comprises a handle, one end of the handle is provided with a roller, the surface of the roller is provided with a plurality of microneedles, the surface of the roller is provided with an elastic layer, the length of the microneedles is 0.5-2mm, the distance between the upper surface of the elastic layer and the tip of the microneedles is 0.2-0.4mm, the position on the elastic layer corresponding to the microneedles is provided with micropores for the microneedles to pass through, and the diameter of the micropores is 2-4 times of the diameter of the microneedles. This prior art, while having an elastic layer designed to allow continuous rolling of the device over the skin, does not allow for administration during continuous rolling, and therefore does not address the efficiency of use and uniformity of transdermal administration.
Therefore, it is necessary to develop a device that can improve the use efficiency and transdermal drug delivery uniformity, improve the customer experience, and prevent the skin from being scratched during use.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a transmission structure, a liquid feeding device applying the transmission structure and a using method thereof.
According to the present invention, there is provided a transmission structure, comprising: first casing, cavity, first elastomer, second casing, power transmission mechanism, wherein:
The front end of the second shell is sleeved and connected with the first shell, a cavity body is arranged in the first shell, the cavity body is abutted with the first shell through a first elastic body, the rear end of the second shell is provided with a second elastic body,
When the first shell is subjected to external force, displacement is generated, the cavity body is contacted with the power transmission mechanism, and the cavity body is controlled to reciprocate in a set amplitude through the second elastic body and the first elastic body.
Preferably, the power transmission mechanism further comprises a limiting piece, and the limiting piece is in interference fit with the power transmission mechanism after being subjected to external force.
Preferably, the outer periphery of the cavity is provided with an arc groove, and the limiting piece is fixedly connected with the cavity through the arc groove.
Preferably, one end of the first shell is provided with an opening, and the other end of the first shell is provided with a clamping limit for the opening.
Preferably, when the first shell is subjected to external force, the first shell displaces according to a set range and compresses the second elastic body, the cavity body, the first elastic body and the limiting piece are driven to displace in the second shell according to the set range, the cavity body and the limiting piece are contacted with the power transmission mechanism to vibrate, and at the moment, the cavity body and the first shell relatively move.
Preferably, when the first housing is not subjected to external force, gaps exist between the cavity and the limiting piece and the power transmission mechanism.
Preferably, when the cavity body is in a return state in the reciprocating motion within the set amplitude, the liquid outlet of the cavity body does not exceed the full opening of the first shell.
Preferably, the cavity reciprocates within an amplitude of 0-10mm when the cavity is in contact with the power train.
The invention provides a liquid feeding device which uses the transmission structure to feed liquid.
The invention also provides a use method of the liquid feeding device, which comprises the following steps:
step 1: the cavity body is arranged in the first shell and assembled with the limiting piece through the arc groove;
step 2: starting a power switch button of the liquid feeding device to perform liquid feeding operation;
Step 3: after the first shell on the liquid feeding device contacts the skin, pressing operation is carried out, the first shell and the cavity body shrink backwards towards the inner direction of the liquid feeding device, so that the power transmission mechanism contacts a limiting piece at the tail part of the cavity body, the cavity body starts vibrating, and meanwhile liquid in the cavity body flows out under the effect of vibration to feed liquid;
Step 4: after the power transmission mechanism contacts the limiting piece at the tail part of the cavity body, the first elastic body provides a return acting force when the cavity body is pushed to the top by the power transmission mechanism, so that the distance between the first shell and the stressed contact surface is smaller than that between the first shell and the stressed contact surface when the cavity body is in a return state.
Compared with the prior art, the invention has the following beneficial effects:
1. According to the invention, the vibration speed of the transmission structure is larger than the moving speed in use, and the second elastic body and the first elastic body form the secondary transmission structure, so that the technical problem that the cavity body cannot throw out liquid due to vibration under the action of no force is solved, and the technical effects that the first shell can slide on the force bearing surface and the cavity body can relatively displace with the first shell under the condition of high-frequency vibration, and the force bearing surface of the first shell cannot be scratched and pulled are achieved.
2. According to the invention, the first elastic body provides a return acting force when the cavity body is pushed to the top by the power transmission mechanism, so that the first shell can vibrate axially after being in contact with skin for transmission, thereby not only penetrating the stratum corneum of the skin to promote the permeation and absorption of liquid medicine, but also overcoming the technical defect that the traditional transdermal drug delivery device can only perform point lifting operation along the vibration direction of the micro device.
3. According to the invention, the second elastic body is arranged, so that the whole transmission structure is separated from the power transmission mechanism in a vibrating normal state, and the cavity body cannot throw out liquid medicine under the action of stress due to vibration.
4. According to the invention, through the improved transmission structure, the sliding drug delivery operation can be carried out on the skin, so that the transdermal drug delivery efficiency and uniformity are improved, and the user experience is improved.
Drawings
Other features, objects and advantages of the present invention will become more apparent upon reading of the detailed description of non-limiting embodiments, given with reference to the accompanying drawings in which:
Fig. 1 is a schematic diagram of the overall structure of the transmission structure in the present invention.
In the figure:
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the present invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications could be made by those skilled in the art without departing from the inventive concept. These are all within the scope of the present invention.
As shown in fig. 1, the present invention provides a transmission structure including a first housing 1, a cavity 2, a microdevice 3, a first elastic body 4, a second elastic body 5, a second housing 6, a power transmission mechanism 7, and a stopper 8.
Wherein, the front end of second casing 6 is established with first casing 1 cover and is connected, is provided with cavity body 2 in the first casing 1, and cavity body 2 passes through first elastomer 4 and first casing 1 looks butt, and the rear end of second casing 6 is provided with second elastomer 5, produces the displacement when first casing 1 receives the exogenic action, and cavity body 2 contacts with power transmission mechanism 7 to through second elastomer 5 and first elastomer 4 control cavity body 2 reciprocating motion in setting for the amplitude.
Furthermore, symmetrical circular arc grooves are formed in the outer periphery of the cavity body 2, and the limiting piece 8 is fixedly connected with the cavity body 2 through the circular arc grooves, so that the cavity body 2 can be conveniently installed or taken out; the limiting piece 8 is in interference fit with the power transmission mechanism 7, and the micro device 3 is arranged at the liquid outlet of the cavity body 2; the second housing 6 is in sliding engagement with the first housing 1. The second elastic body 5 is sleeved outside the power transmission mechanism 7, and the power transmission mechanism 7 is arranged at the rear end of the cavity body 2.
Still further, the front end of the second housing 6 is close to the liquid outlet direction, and the rear end of the second housing 6 is close to the power transmission mechanism 7; one end of the second elastic body 5 abuts against the rear end of the first housing 1, and the other end abuts against the second housing 6. One end of the first elastic body 4 is abutted against the blocking edge in the first shell 1, and the other end is abutted against the limiting piece 8. The first shell 1 has an opening at one end and a clamping limit at the other end.
Further, when the first housing 1 is not in contact with the skin, the cavity 2 and the stopper 8 have a gap with the power transmission mechanism 7.
The preferred embodiment of the present invention will be further described.
Based on the above embodiments, the micro-device 3 comprises a nano-wafer or nano-microneedle, a radio frequency and laser device, etc. capable of feeding liquid.
Based on the above embodiment, the second housing 6 and the first housing 1 are limited by the buckle, and the limiting member 8 is limited in the first housing 1 by the buckle of the first housing 1, the cavity 2 and the first elastic body 4.
Based on the above embodiment, when the cavity 2 reciprocates in the set amplitude and is in the return state, the liquid outlet of the cavity 2 does not exceed the full opening of the first housing 1, at this time, the distance between the first housing 1 and the stressed contact surface, which is spaced from the liquid outlet of the cavity 2, is greater than 0, and the cavity 2 can freely move on the stressed surface.
Based on the above embodiment, when the vibration speed of the cavity 2 reaches 3000-15000 times per minute, the vibration speed of the cavity 2 is far greater than the moving speed in use, so that the cavity 2 keeps vibrating at a high speed in the process of freely moving after the first shell contacts the stress surface, and the stress surface can not be scratched.
The present invention will be further described in the following examples.
Based on the above embodiment, the micro device 3 may also be a liquid outlet device provided with a through hole, and be applied in industrial fields, such as glue application field, etc.
The invention also provides a liquid feeding device which uses the transmission structure to feed liquid, the liquid feeding device can enable the first shell 1 to lightly press after contacting the stress surface, the first shell 1 and the cavity body 2 shrink backwards together according to a set distance, after the power transmission mechanism 7 contacts the limiting piece 8 of the cavity body 2, the cavity body 2 and the micro device 3 start vibrating, meanwhile, the liquid medicine in the cavity body 2 flows out to the skin surface under the effect of vibration, and the micro device 3 conducts the skin cuticle to promote the penetration and absorption of the liquid medicine.
The invention also provides a use method of the liquid feeding device, which uses the liquid feeding device to feed liquid, and comprises the following steps:
Step 1: the cavity body 2 is arranged in the first shell 1 and is assembled with the limiting piece 8 through an arc groove;
step 2: starting a power switch button of the liquid feeding device to perform liquid feeding operation;
Step 3: after the first shell 1 on the liquid feeding device is contacted with skin, pressing operation is carried out, the first shell 1 and the cavity body 2 shrink backwards towards the inner direction of the liquid feeding device, so that the power transmission mechanism 7 is contacted with the limiting piece 8 at the tail part of the cavity body 2, the cavity body 2 starts vibrating, and meanwhile, liquid in the cavity body 2 flows out under the action of vibration to feed liquid;
Step 4: after the power transmission mechanism 7 contacts with the limiting piece 8 at the tail part of the cavity body 2, the first elastic body 4 provides a return acting force when the cavity body 2 is pushed to the top by the power transmission mechanism 7, so that the distance between the first shell 1 and the stressed contact surface is smaller than that between the cavity body 2 and the stressed contact surface in a return state.
Meanwhile, in the course of moving after the whole first housing 1 contacts the skin, the vibration speed of the transmission structure is greater than the moving speed in use.
Working principle:
When the first shell 1 is acted by external force, the first shell 1 drives the limiting piece 8 to apply pressure to the first elastic body 4 and the second elastic body 5, so that the first elastic body 4 and the second elastic body 5 deform simultaneously, and at the moment, the micro device 3 punctures the skin and then shakes to deliver the liquid medicine for transdermal drug delivery; when the cavity body 2 reciprocates in a set amplitude and is in a return state, the liquid outlet of the cavity body 2 does not exceed the full opening of the first shell 1, at the moment, the distance between the first shell 1 and the liquid outlet of the cavity body 2 at the stressed contact surface is greater than 0, and the transmission structure can freely move on the stressed surface; when the first shell 1 moves after contacting the stress surface, the vibration speed of the transmission structure is larger than the moving speed in use.
In the description of the present application, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present application.
The foregoing describes specific embodiments of the present application. It is to be understood that the application is not limited to the particular embodiments described above, and that various changes or modifications may be made by those skilled in the art within the scope of the appended claims without affecting the spirit of the application. The embodiments of the application and the features of the embodiments may be combined with each other arbitrarily without conflict.
Claims (9)
1. A transmission structure, comprising: first casing (1), cavity (2), first elastomer (4), second elastomer (5), second casing (6), power transmission mechanism (7), wherein:
The front end of the second shell (6) is sleeved and connected with the first shell (1), the first shell (1) is internally provided with the cavity body (2), the cavity body (2) is abutted with the first shell (1) through the first elastic body (4), the rear end of the second shell (6) is provided with the second elastic body (5),
When the first shell (1) is subjected to external force, displacement is generated, the cavity body (2) is in contact with the power transmission mechanism (7), and the cavity body (2) is controlled to reciprocate within a set amplitude through the second elastic body (5) and the first elastic body (4);
When the cavity body (2) reciprocates in a set amplitude and is in a return state, the liquid outlet of the cavity body (2) does not exceed the full opening of the first shell (1).
2. The transmission structure according to claim 1, further comprising a limiting member (8), wherein the limiting member (8) is in interference fit with the power transmission mechanism (7) after being subjected to an external force.
3. The transmission structure according to claim 2, characterized in that the outer peripheral portion of the cavity (2) is provided with an arc groove, and the stopper (8) is fastened and connected with the cavity (2) through the arc groove.
4. The transmission structure according to claim 1, characterized in that the first housing (1) has an opening at one end and an opening at the other end and has a detent restriction.
5. The transmission structure according to claim 2, wherein when the first housing (1) is subjected to an external force, and then displaces according to a set range, and compresses the second elastic body (5), the cavity (2) is driven to displace according to a set range together with the first elastic body (4) and the limiting piece (8) in the second housing (6), and the limiting piece (8) contacts the power transmission mechanism (7) to vibrate, at this time, the cavity (2) and the first housing (1) move relatively.
6. The transmission structure according to claim 2, characterized in that the cavity (2) and the stop member (8) are both in clearance with the power transmission mechanism (7) when the first housing (1) is not subjected to an external force.
7. A transmission structure according to claim 1, characterized in that the cavity (2) reciprocates within an amplitude of 0-10mm when the cavity (2) is in contact with the power transmission mechanism (7).
8. A fluid delivery device, characterized in that the transmission structure according to any one of claims 1-7 is used for delivering fluid.
9. A method of using the liquid delivery device of claim 8 to deliver liquid comprising the steps of:
Step 1: the cavity body (2) is arranged in the first shell (1) and is assembled with the limiting piece (8) through an arc groove;
step 2: starting a power switch button of the liquid feeding device to perform liquid feeding operation;
Step 3: after the first shell (1) on the liquid feeding device is used for contacting the skin, pressing operation is carried out, the first shell (1) and the cavity body (2) shrink backwards towards the inner direction of the liquid feeding device, so that the power transmission mechanism (7) contacts with the limiting piece (8) at the tail part of the cavity body (2), the cavity body (2) starts vibrating, and meanwhile liquid in the cavity body (2) flows out to feed liquid under the action of vibration;
step 4: after the power transmission mechanism (7) contacts with the limiting piece (8) at the tail part of the cavity body (2), the first elastic body (4) provides a return acting force when the cavity body (2) is pushed to the top by the power transmission mechanism (7), so that the distance between the first shell (1) and the stressed contact surface is smaller than the distance between the cavity body (2) and the stressed contact surface in a return state.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110033302.9A CN114748778B (en) | 2021-01-11 | 2021-01-11 | Transmission structure, liquid feeding device applying transmission structure and use method of liquid feeding device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110033302.9A CN114748778B (en) | 2021-01-11 | 2021-01-11 | Transmission structure, liquid feeding device applying transmission structure and use method of liquid feeding device |
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| CN114748778A CN114748778A (en) | 2022-07-15 |
| CN114748778B true CN114748778B (en) | 2024-05-03 |
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| CN115336982B (en) * | 2022-08-25 | 2024-05-17 | 苏州纳生微电子有限公司 | Skin elasticity measuring method and measuring system |
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| CN102753221A (en) * | 2009-12-16 | 2012-10-24 | 贝克顿·迪金森公司 | Self- injection device |
| JP2012100783A (en) * | 2010-11-08 | 2012-05-31 | Nanbu Plastics Co Ltd | Liquid medicine supply device |
| CN111212675A (en) * | 2017-10-17 | 2020-05-29 | 3M创新有限公司 | Applicator for applying microneedle arrays to skin |
| KR20190107538A (en) * | 2018-03-12 | 2019-09-20 | 연세대학교 산학협력단 | Micro-needle Applicator |
| WO2020076018A1 (en) * | 2018-10-08 | 2020-04-16 | 연세대학교 산학협력단 | Microstructure applicator |
| CN110368576A (en) * | 2019-08-23 | 2019-10-25 | 苏州纳生微电子有限公司 | Quantitative liquid feedway |
| CN110681043A (en) * | 2019-10-23 | 2020-01-14 | 苏州微亮生物科技有限公司 | Micro-guiding infiltration device |
| GB201918706D0 (en) * | 2019-12-18 | 2020-01-29 | Enesi Pharma Ltd | Improvements in needle-free delivery |
| CN212282542U (en) * | 2020-07-15 | 2021-01-05 | 深圳德技创新实业有限公司 | Needle head structure and electric microneedle device |
| CN215135866U (en) * | 2021-01-11 | 2021-12-14 | 苏州纳生微电子有限公司 | Transmission mechanism suitable for liquid feeding device and liquid feeding device |
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