CN114748103A - Multi-mode ultrasonic imaging method, device and system in heart cavity - Google Patents

Multi-mode ultrasonic imaging method, device and system in heart cavity Download PDF

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CN114748103A
CN114748103A CN202210379186.0A CN202210379186A CN114748103A CN 114748103 A CN114748103 A CN 114748103A CN 202210379186 A CN202210379186 A CN 202210379186A CN 114748103 A CN114748103 A CN 114748103A
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王亚华
陈明心
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Shenzhen Huanying Medical Technology Co ltd
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    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0883—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the heart
    • A—HUMAN NECESSITIES
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    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4245—Details of probe positioning or probe attachment to the patient involving determining the position of the probe, e.g. with respect to an external reference frame or to the patient
    • A61B8/4254—Details of probe positioning or probe attachment to the patient involving determining the position of the probe, e.g. with respect to an external reference frame or to the patient using sensors mounted on the probe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
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    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
    • A61B8/5246—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image combining images from the same or different imaging techniques, e.g. color Doppler and B-mode

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Abstract

The invention provides a multi-mode ultrasonic imaging method, a device and a system in a heart cavity, wherein the method comprises the following steps: inserting the ultrasonic imaging catheter into a heart cavity along a blood vessel, and performing real-time B-mode imaging on the inner part of the heart cavity; adjusting the position of the probe; setting an acquisition cycle of multi-mode ultrasonic signal acquisition, and adjusting position information to perform multi-mode ultrasonic signal acquisition on a plurality of regions to be observed; and carrying out data processing on the ultrasonic signals under each position information, and acquiring the cardiac cavity tissue characteristics of each region to be observed in an acquisition cycle by combining a time sequence. According to the scheme of the invention, four-dimensional multi-modal imaging and parameter measurement can be carried out on the heart tissue, the three-dimensional heart cavity structure, the myocardial tissue displacement, the strain, the elasticity and other related information at different moments of the heartbeat cycle are measured from the inside of the heart cavity, the heart cavity tissue characteristics of the heart tissue are obtained, and multi-dimensional mechanical parameter measurement is realized.

Description

Multi-mode ultrasonic imaging method, device and system in heart cavity
Technical Field
The invention relates to the field of medical imaging, in particular to a method, a device and a system for multi-mode ultrasonic imaging in a heart cavity.
Background
Intracardiac echocardiography (ICE) is a technique for real-time imaging of Intracardiac structures by transvascular placement of a catheter containing an ultrasound probe into the heart chamber. Compared with conventional in vitro cardiac ultrasound imaging, ICE can help doctors to see structures in heart chambers more clearly and intuitively, and is often used for guiding myocardial Radio Frequency Ablation (RFA) to treat diseases such as atrial fibrillation and other arrhythmia.
However, the real-time two-dimensional ultrasound B image utilized by the ICE can only provide information on the structure and the tissue morphology of the heart chamber, so that it is difficult to accurately control the position and the size of the ablation site by guiding the myocardial radio-frequency ablation only through the echocardiogram, and it is also difficult to accurately monitor the ablation process. Since the mechanical properties (such as elasticity (or hardness)) of the myocardial tissue at the ablation part can be obviously changed before and after ablation, if the mechanical properties of the myocardial tissue at the ablation area can be measured and imaged in real time, the ablation can be accurately monitored. Furthermore, the pathology and functional imbalance of the heart are closely related to the mechanical properties of the heart tissue (including the myocardium and heart valves), which are also closely related to the health of the cardiovascular and other peripheral systems. Therefore, measurement of in vivo cardiac tissue mechanical parameters is very necessary.
The ultrasonic elastic imaging (ultrasound elastic imaging) technology is a series of methods for directly or indirectly measuring the elasticity (or hardness) of soft tissues by using ultrasonic waves. Common ultrasound Elastography such as Shear Wave Elastography (Shear Wave Elastography), Strain imaging (Strain imaging), etc. Due to the characteristics of safety, real-time performance and the like, the ultrasonic elastography technology is widely used for representing the mechanical characteristics of various biological soft tissues and evaluating the health of the tissues and the body according to the mechanical characteristics.
However, since the heart is located deep in the chest cavity and is shielded by the ribs and lung lobes, the myocardial area in which elasticity can be measured generally by external ultrasound transthoracically is very limited and difficult to measure effectively. In addition, since the heart tissue in the body is in a periodic motion state all the time, the tissue mechanical properties thereof are also constantly changed and closely related to the blood pressure.
For myocardial radio frequency ablation guidance and monitoring, although real-time two-dimensional ultrasound B images utilized by ICE can provide cardiac chamber structure and tissue morphology information, it is difficult to accurately position a focus region and an actually ablated region. Although the ablation process can be monitored in a quasi-real-time manner by using the magnetic resonance temperature imaging, the requirement on equipment is high, the operation is complex and the cost is high. Aiming at the mechanical parameter measurement of in-vivo heart tissue, the existing in-vitro ultrasonic method is difficult to flexibly and accurately carry out large-range and multidimensional mechanical measurement on in-vivo heart tissue due to the position of the heart.
Disclosure of Invention
Based on the problems in the prior art, the invention provides a method, a device and a system for multi-modal ultrasonic imaging in a heart chamber. The specific scheme is as follows:
a method of intracardiac multi-modality ultrasound imaging, comprising the steps of:
inserting the ultrasonic imaging catheter connected with the probe into a heart cavity along a blood vessel, and carrying out real-time B-mode imaging on the inner part of the heart cavity;
adjusting the position of the probe to obtain a region to be observed and position information corresponding to the probe;
setting an acquisition cycle of preset multi-mode ultrasonic signal acquisition, and taking a certain moment in a heartbeat cycle as an acquisition starting moment, wherein the acquisition starting moment has a specific signal form in an ECG signal;
when the signal form in the real-time ECG signal of the detected individual is detected, the multi-mode ultrasonic signal acquisition is started to be carried out on the area to be observed, and the ultrasonic signal acquired by the probe under the position information is obtained and stored;
adjusting the position information of the probe, replacing the region to be observed, and performing the multi-mode ultrasonic signal acquisition again to obtain the ultrasonic signals acquired by the probe in the same or different position information in the heart cavity;
and carrying out data processing on the ultrasonic signals under each position information, and acquiring the heart cavity tissue characteristics of each region to be observed in an acquisition period by combining a time sequence.
In a particular embodiment, the heart chamber tissue characteristics include: the change of the three-dimensional heart chamber structure, the myocardial tissue displacement, the strain and the elastic wave velocity distribution in the heart chamber along with the time in each heart beat period.
In a specific embodiment, the obtaining of the heart chamber tissue characteristics comprises:
processing data of ultrasonic signals acquired by the probe under different position information in a single acquisition cycle to obtain first tissue information data about dynamic displacement and strain of tissue and second tissue information data about elasticity of the tissue;
based on the first tissue information data and the second tissue information data, combining the time sequence of the multi-modal ultrasonic signal acquisition to obtain tissue displacement, strain and elastic wave velocity information of different regions to be observed changing along with time in an acquisition cycle;
and converting the tissue displacement, the strain and the elastic wave velocity information into positions corresponding to the heart cavity tissue during signal acquisition according to corresponding probe position information and imaging parameters to obtain the three-dimensional characteristics of the heart cavity tissue at different moments of the heartbeat cycle.
In a particular embodiment, the multi-modality ultrasound signal acquisition particularly comprises:
transmitting ultrasonic signals according to a preset sequence, and alternately acquiring a single-frame image for ultrasonic strain imaging and transient elastic information for shear wave elastic imaging according to a preset sequence on tissues of a region to be observed to obtain first signal data related to the ultrasonic strain imaging and second signal data related to the shear wave elastic imaging.
In a specific embodiment, "interleaving, in a preset order, single-frame image acquisition for ultrasonic strain imaging and transient elasticity information acquisition for shear wave elastography on a tissue of a region to be observed to obtain first signal data related to the ultrasonic strain imaging and second signal data related to the shear wave elastography" specifically includes:
firstly, acquiring a first single-frame image, and immediately acquiring transient elastic information of the area to be observed after the acquisition of the first single-frame image is finished; or, first transient elastic information acquisition is carried out, and after the first transient elastic information acquisition is finished, first single-frame image acquisition is carried out on the region to be observed immediately;
after the first transient elastic information acquisition and the first single-frame image acquisition are finished, acquiring each subsequent single-frame image about ultrasonic strain imaging by taking the first single-frame image acquisition as a starting point according to a preset first acquisition frequency, and acquiring transient elastic information about shear wave elastic imaging at a subsequent moment by taking the first transient elastic information acquisition as a starting point according to a preset second acquisition frequency;
when the single-frame image acquisition is completed at the first acquisition frequency and the transient elastic information acquisition is completed at the second acquisition frequency, the ultrasonic signal acquisition of one acquisition period can be realized.
In a specific embodiment, when the multi-modal ultrasound signal acquisition starts, the position information of the probe is synchronously acquired and recorded;
constructing a spatial coordinate system about the heart chamber based on the location information to describe a specific location of the probe within the heart chamber;
the position information comprises position coordinates of the probe in the heart cavity and an azimuth angle of the probe, the probe is provided with a positioning device, and the position information of the probe is determined through the positioning device.
In a particular embodiment, the acquisition period is no less than one complete cardiac cycle;
the time interval between two adjacent single-frame image acquisition is not more than the time interval between two adjacent transient elastic information acquisition;
the time interval between two adjacent single-frame image acquisition is not less than the acquisition time of one transient elastic information acquisition.
A multi-mode ultrasonic imaging device in a heart cavity comprises,
a detection unit: the ultrasonic imaging catheter is used for inserting the ultrasonic imaging catheter connected with the probe into a heart cavity along a blood vessel and carrying out real-time B-mode imaging on the inner part of the heart cavity;
an area acquisition unit: the device is used for adjusting the position of the probe and acquiring a region to be observed and position information corresponding to the probe;
a cycle setting unit: the system is used for setting an acquisition cycle for presetting multi-mode ultrasonic signal acquisition, and takes a certain moment in a heartbeat cycle as an acquisition starting moment, wherein the acquisition starting moment has a specific signal form in an ECG signal;
a multi-modality unit: the system is used for starting to carry out the multi-mode ultrasonic signal acquisition on a region to be observed when the signal form in the real-time ECG signal of the detected individual is detected, and obtaining and storing the ultrasonic signal acquired by the probe under the position information;
the region adjusting unit is used for adjusting the position information of the probe, replacing a region to be observed and carrying out multi-mode ultrasonic signal acquisition again so as to obtain ultrasonic signals acquired by the probe under the same or different position information in the heart cavity;
and the data processing unit is used for carrying out data processing on the ultrasonic signals under each position information and acquiring the heart cavity tissue characteristics of each region to be observed in the acquisition period by combining the time sequence.
In a particular embodiment, the multimodal unit comprises in particular:
when multi-mode ultrasonic signal acquisition is carried out, ultrasonic signals are transmitted according to a preset sequence, and single-frame image acquisition for ultrasonic strain imaging and transient elastic information acquisition for shear wave elastic imaging are carried out on tissues of a region to be observed in a penetrating mode according to a preset sequence, so that first signal data related to the ultrasonic strain imaging and second signal data related to the shear wave elastic imaging are obtained.
An intracardiac multi-modality ultrasound imaging system for implementing the intracardiac multi-modality ultrasound imaging method of any one of the above, the system comprising:
the ultrasonic imaging catheter subsystem comprises a probe and an ultrasonic imaging catheter which are connected with each other, wherein an ultrasonic transducer and a positioning device are arranged on the probe and used for inserting the ultrasonic imaging catheter and the probe into a heart cavity along a blood vessel, carrying out real-time B-mode imaging on the interior of the heart cavity by transmitting and receiving signals through the ultrasonic transducer, and positioning the ultrasonic transducer through the positioning device;
the ECG acquisition and storage subsystem is used for acquiring and storing the electrocardiosignals in real time;
the multi-mode ultrasonic imaging subsystem is respectively connected with the ultrasonic imaging catheter subsystem and the ECG acquisition and storage subsystem and is used for controlling the ultrasonic transducer to transmit and receive ultrasonic signals and controlling the conversion, storage, processing and image display of the ultrasonic signals;
and the positioning subsystem is used for acquiring the position information of the ultrasonic transducer.
Has the advantages that:
the invention provides a method, a device and a system for multi-modal ultrasonic imaging in a heart cavity, which are used for carrying out four-dimensional multi-modal imaging and mechanical parameter measurement on heart tissues by utilizing an ICE ultrasonic probe catheter and can accurately obtain the characteristics of the heart cavity tissues in the heart cavity. The scheme of the invention not only can carry out multi-mode ultrasonic imaging from the inside of the heart, but also can realize the measurement of the mechanical properties of the heart tissue. Through shear wave elasticity imaging, the elastic modulus of the tissue can be measured; through strain imaging, information related to dynamic strain and displacement of tissue can be measured. Through multi-time multi-mode ultrasonic imaging acquisition, multi-angle multi-section data acquisition can be carried out on the same or different positions in the heart cavity, information in the heart cavity can be acquired more comprehensively, and diagnosis is facilitated. The ultrasonic strain imaging and the shear wave elastic imaging can be simultaneously carried out on the heart tissue through one-time acquisition sequence, the independent imaging is not needed, the relevant information such as the dynamic strain, the elastic modulus and the like of the tissue at any time or under a stress state can be measured, and the clinical diagnosis is facilitated.
In order to make the aforementioned and other objects, features and advantages of the present invention comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and those skilled in the art can also obtain other related drawings based on the drawings without inventive efforts.
FIG. 1 is a flow chart of a method of intracardiac multi-modality ultrasound imaging of the present invention;
FIG. 2 is a schematic structural diagram of a multi-modality ultrasound imaging system in a cardiac chamber of the present invention;
FIG. 3 is a schematic view of the operation of the probe of the present invention within the heart chamber
FIG. 4 is a sequence diagram of a multi-modality ultrasound signal acquisition of the present invention;
FIG. 5 is a pulse diagram of a single shear wave elastography signal acquisition process of the present invention;
fig. 6 is a schematic diagram of a module of the multi-modality ultrasonic imaging apparatus in the heart chamber of the present invention.
Reference numerals: 1-an ultrasound imaging catheter subsystem; 2-a multi-modal ultrasound signal acquisition subsystem; 3-a positioning subsystem; 4-an ECG acquisition and storage subsystem; 11-a probe; 12-an ultrasound imaging catheter; 13-a steering control mechanism; 14-a connection plug; 111-an ultrasonic transducer; 112-positioning means.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The term "tissue" as used herein refers to a tissue of a living body, particularly a tissue under a varying force, such as a heart, a blood vessel, a muscle under tension or compression, and example 1
The embodiment provides a multi-modality ultrasonic imaging method in a heart chamber, which is used for measuring characteristics of a three-dimensional heart chamber structure, myocardial tissue displacement, strain, elasticity and the like which change along with time from the inside of the heart chamber and realizing the acquisition of the characteristics of the heart chamber tissue in the heart chamber. The flow chart of the intracardiac multi-modal ultrasonic imaging method is shown in the attached figure 1 of the specification, and the specific scheme is as follows:
a method of intracardiac multi-modality ultrasound imaging, comprising the steps of:
101. inserting the ultrasonic imaging catheter connected with the probe into a heart cavity along a blood vessel, and performing real-time B-mode imaging on the inner part of the heart cavity;
102. adjusting the position of the probe to obtain a region to be observed and position information corresponding to the probe;
103. setting an acquisition cycle of preset multi-mode ultrasonic signal acquisition, and taking a certain moment in a heartbeat cycle as an acquisition starting moment, wherein the acquisition starting moment has a specific signal form in an ECG signal;
104. when the signal form in the real-time ECG signal of the detected individual is detected, multi-mode ultrasonic signal acquisition is carried out on the area to be observed, and the ultrasonic signal acquired by the probe under the position information is obtained and stored;
105. adjusting the position information of the probe, replacing the region to be observed, and performing multi-mode ultrasonic signal acquisition again to obtain ultrasonic signals acquired by the probe under the same or different position information in the heart cavity;
106. and carrying out data processing on the ultrasonic signals under each position information, and acquiring the heart cavity tissue characteristics of each region to be observed in an acquisition period by combining a time sequence.
A multi-modality ultrasound imaging method in a cardiac chamber based on the present embodiment provides a multi-modality ultrasound imaging system in a cardiac chamber, a schematic structural diagram of which is shown in fig. 2 in the specification, and the system includes an ultrasound imaging catheter subsystem, an ECG acquisition and storage subsystem, a multi-modality ultrasound imaging subsystem, and a positioning subsystem.
It should be noted that, this embodiment provides a multi-modality ultrasound signal acquisition, which specifically includes: transmitting and receiving ultrasonic signals according to a preset sequence, and alternately acquiring signals for strain imaging and signals for shear wave elastography on cardiac tissues of a region to be imaged according to the preset sequence. The interleaving is understood to mean that another signal acquisition is interleaved in one signal acquisition, rather than completing one signal acquisition first and then performing another signal acquisition. Due to the requirement of the time dimension, the present embodiment requires multiple acquisitions in each signal acquisition process. For example, the signal acquisition for strain imaging includes a acquisition, the signal acquisition for shear wave elastography includes B acquisition, and the alternating operation is to perform B acquisition in the a acquisition process to distinguish the conventional acquisition mode of performing a acquisition first and then B acquisition.
The ultrasound imaging catheter subsystem comprises an ultrasound transducer assembly, a positioning device, an ultrasound imaging catheter, a steering control mechanism and a connecting plug. The ultrasonic transducer and the positioning device are positioned in the tip of the ultrasonic imaging catheter and jointly form a probe, and the flexible circuit of the ultrasonic transducer and the positioning device is connected with the connecting plug through the inner cavity of the catheter. The method of the embodiment does not need to change the hardware structure of the catheter greatly, and does not need high hardware cost. Compared with the prior art in which the ablation process is realized through magnetic resonance temperature imaging, the scheme of the embodiment has the advantages of high monitoring precision, low requirement on equipment, simplicity in operation and low cost.
101. The ultrasonic imaging catheter connected with the probe is inserted into a heart cavity along a blood vessel, and real-time B-mode imaging is carried out on the inner part of the heart cavity. Specifically, the ultrasonic imaging catheter together with the probe is inserted into a heart cavity through a blood vessel, and the working schematic diagram of the ultrasonic imaging catheter in the heart cavity is shown in the attached figure 3 of the specification. The displacement and the steering of the probe in the heart cavity are controlled by adjusting a steering control mechanism outside the body, and the probe is positioned and oriented by a positioning subsystem.
102. And adjusting the position of the probe to acquire the region to be observed and the position information corresponding to the probe. In this embodiment, the position information includes the angle of the probe and the position at which the probe is located. When the multi-modal ultrasound signal acquisition starts, the position information of the probe is synchronously acquired and recorded.
Because the heart cavity is a three-dimensional space, each region acquired by the probe in the heart cavity needs to be embodied and presented in the heart cavity, the position of the probe is coordinated, and each region to be observed is digitized. Preferably, when the multi-modal ultrasound signal acquisition starts, the position information of the probe is synchronously acquired and recorded; by constructing a spatial coordinate system about the heart chamber, the specific location of the probe within the heart chamber is described based on the location information. The position information comprises position coordinates of the probe in the heart cavity and an azimuth angle of the probe, the probe is provided with a positioning device, and the position information of the probe is determined through the positioning device. The probe can be carried with a positioning device, the coordinates of the positioning device are the coordinates of the probe, and the positioning device can be used for positioning in vitro, so that the position coordinates of the probe can be conveniently tracked.
Specifically, the angle and the position of the probe are adjusted, the region to be observed in the cardiac tissue under the position information is obtained through real-time B-mode imaging, and relevant parameters of the real-time B-mode imaging are optimized and adjusted according to the position, the size, the sound attenuation and other information of the region to be observed.
The heart cycle, also called cardiac cycle, refers to the process that the cardiovascular system undergoes from the start of one heart beat to the start of the next heart beat. The internal pressure decreases during diastole, the vena cava blood flows back into the heart, and the internal pressure increases during systole, pumping the blood into the artery. Each contraction and relaxation of the heart constitutes a cardiac cycle. The first of these is a two-atrial contraction in one cardiac cycle, in which the right atrium contracts slightly before the left atrium. The atria begin to dilate and the two ventricles contract, while the left ventricle contracts slightly before the right ventricle. In the late phase of ventricular relaxation the atria start to contract again. For example, an average adult heart rate of 75 beats per minute averages 0.8 seconds per cardiac cycle, with atrial systole averaging 0.11 seconds and diastolic averaging 0.69 seconds. The ventricular systole averages 0.27 seconds, and the diastole averages 0.53 seconds. At different times of the heart cycle, there are different manifestations in the ECG signal (electrocardiosignal). For example, the R-wave of an ECG signal can be used as the starting point for acquisition, i.e. corresponding to the atrioventricular valve closing moment (or the beginning of systole). Preferably, one acquisition cycle should be no less than one full heartbeat cycle.
104. And after a signal form corresponding to the acquisition starting moment in the ECG signal is detected, performing multi-mode ultrasonic signal acquisition on the region to be observed to obtain and store the ultrasonic signal acquired by the probe under the position information.
In this embodiment, the ECG signal in the cardiac chamber is acquired by the ECG acquisition and storage subsystem, and once the signal form corresponding to the acquisition start time in the ECG signal is detected, the multi-modal ultrasound imaging subsystem is triggered to transmit and acquire the ultrasound signal according to the sequence shown in fig. 4 of the specification. An ultrasonic imaging system is triggered to acquire signals through real-time electrocardiosignals, and an acquisition cycle can be started accurately. And when the acquisition is started, synchronously triggering the recording of the position information in the positioning subsystem. And the acquired ultrasonic signals and the position information of the corresponding probe are jointly stored in the multi-mode ultrasonic imaging subsystem, and the acquired ECG signals are transmitted to the multi-mode ultrasonic imaging subsystem.
In this embodiment, the multi-modality ultrasound signal acquisition specifically includes: in an acquisition period, transmitting ultrasonic signals according to a preset sequence, and alternately acquiring single-frame image acquisition for ultrasonic strain imaging and transient elastic information acquisition for shear wave elastic imaging according to a preset sequence on a tissue of a region to be observed to obtain first signal data about the ultrasonic strain imaging and second signal data about the shear wave elastic imaging. The embodiment provides a special multi-modal ultrasound imaging sequence, which can simultaneously measure the heart cavity structure and the shape, displacement, strain, elasticity and other parameters of the myocardial tissue in different periods in a heartbeat cycle through single acquisition.
Preferably, the signal acquisition for ultrasonic strain imaging comprises at least one single-frame image acquisition, and each single-frame image obtained by one single-frame image acquisition can be synthesized into one high-quality ultrasonic B image for tissue displacement and strain information calculation.
Preferably, the signal acquisition for shear wave elastography includes at least one acquisition of transient elasticity information, the one acquisition of transient elasticity information specifically including: the method comprises the steps of emitting high-energy sound beams, exciting elastic waves in tissues of a region to be observed, switching to a preset ultrafast ultrasonic imaging mode, and performing ultrafast imaging on the tissues to track propagation of the elastic waves.
In the present embodiment, since it is necessary to switch between signal acquisition for ultrasonic strain imaging and signal acquisition for shear wave elastography within one acquisition cycle, one acquisition cycle includes at least two single-frame image acquisitions for ultrasonic strain imaging and at least one transient elasticity information acquisition for shear wave elastography. The imaging method of the strain imaging single frame image and the imaging method for tracking the propagation of the elastic wave are not limited, and may be the same or different.
The preset sequence comprises: in one acquisition cycle, one of the first signal acquisition for ultrasonic strain imaging and the first signal acquisition for shear wave elastography is completed, and then the other of the first signal acquisition for ultrasonic strain imaging and the first signal acquisition for shear wave elastography is immediately performed to obtain approximately the same signal acquisition start time. The scheme of this embodiment needs to ensure that the starting time of two kinds of signal acquisition are approximately the same, so as to realize the measurement of tissue displacement, strain information and tissue elastic modulus information at the same time. The method specifically comprises the steps of immediately carrying out signal acquisition for shear wave elastography for the first time after signal acquisition for ultrasonic strain imaging for the first time is finished; or, the signal acquisition for the ultrasonic strain imaging is carried out immediately after the signal acquisition for the shear wave elastography is completed.
The acquisition process specifically comprises:
firstly, acquiring a first single-frame image to obtain a first frame image related to ultrasonic strain imaging; and after the acquisition of the first single-frame image is finished, immediately acquiring transient elastic information of the region to be observed for the first time to obtain elastic data of the shear wave elastic imaging at the initial moment. The single-frame image acquisition is carried out firstly, so that the interference of tissue displacement caused by high-energy sound beams on strain imaging can be effectively avoided.
Or, first transient elastic information acquisition is carried out, and after the first transient elastic information acquisition is completed, first single-frame image acquisition is immediately carried out on the region to be observed to obtain a first frame image related to ultrasonic strain imaging;
after the acquisition of the first transient elastic information and the acquisition of the first single-frame image are completed, acquiring each subsequent single-frame image related to ultrasonic strain imaging by taking the acquisition of the first single-frame image as a starting point according to a preset first acquisition frequency, and acquiring elastic data related to shear wave elastic imaging at a subsequent moment by taking the acquisition of the first transient elastic information as a starting point according to a preset second acquisition frequency; when the single-frame image acquisition is completed at the first acquisition frequency and the transient elastic information acquisition is completed at the second acquisition frequency, the ultrasonic signal acquisition of one acquisition period can be realized. As shown in figure 4 of the specification.
In fig. 4, a single frame image is acquired as 201 and transient elasticity information is acquired as 202. The first single-frame image acquisition and the first transient elastic information acquisition are continuously carried out, and the first transient elastic information acquisition is carried out immediately after a first frame image signal for ultrasonic strain imaging is acquired. Therefore, the time starting point of single-frame image acquisition and transient elasticity information acquisition is determined, and after the starting point is determined, acquisition is carried out according to the set frequency.
Single frame image acquisition, i.e., data acquisition for obtaining a higher quality ultrasound B image. In the present embodiment, the imaging method of ultrasonic strain imaging is not limited, and includes at least one ultrasonic transmission and reception process. Recording the acquisition time of single-frame image acquisition of ultrasonic strain imaging as TSI。
The primary transient elasticity information acquisition specifically comprises the following steps: the method comprises the steps of firstly emitting high-energy sound beams to excite elastic waves in tissues, then rapidly switching to a preset ultrafast ultrasonic imaging mode, and rapidly imaging the tissues to track propagation of the elastic waves. The specific sequence of transient elastic information acquisition is shown in fig. 5 in the specification, and firstly, a high-energy sound beam is emitted to excite elastic waves in tissues, then, the tissues are rapidly switched to an ultra fast imaging mode (the frame frequency is not less than 1000Hz), and the tissues are rapidly imaged to track the propagation of the elastic waves. Recording the time for acquiring the once complete transient elastic information as TSWE. High energy excitation acoustic beam transmit sequence or excitation for shear wave elastography methods, including but not limited to any one of the known transmit or excitation modesThe method.
In fig. 4, the interval between two adjacent single-frame image acquisitions for ultrasonic strain imaging is denoted as Δ T1The interval between two adjacent transient elastic information acquisitions for shear wave elastography is recorded as delta T2. Preferably, the interval between the single frame image acquisition of two adjacent ultrasonic strain imaging is not less than the acquisition time of one transient elastic information acquisition. Namely, Delta T2≥ΔT1And Δ T1≥TSWE。
Further preferably, there is no time coincidence between each single frame image acquisition and each transient elasticity information acquisition. Reasonably designed delta T1、ΔT2、TSIAnd TSWEThe time coincidence between the single-frame image acquisition and the transient elastic information acquisition can be avoided. Thus, the first acquisition frequency and the second acquisition frequency may be the same or different. Only if no time conflict exists between the two imaging modes, the tissue displacement, the strain information and the elastic modulus information can be acquired simultaneously. The reasonable design of the acquisition period can measure the non-linear mechanical characteristics of the tissues.
105. And adjusting the position information of the probe, replacing the region to be observed, and performing multi-mode ultrasonic signal acquisition again to obtain the ultrasonic signals acquired by the probe in the same or different position information in the heart cavity. And (6) repeating the step 104, and carrying out multi-angle multi-section multi-modal ultrasonic signal acquisition on the probe in the same or different position information in the heart cavity. The ultrasonic imaging catheter is provided with an adjustable bending section, the end part of the ultrasonic imaging catheter can be freely bent under the assistance of a bending adjusting mechanical structure of the adjustable bending section, and the ultrasonic transducer can rotate 360 degrees along the axial line of the ultrasonic imaging catheter, so that the myocardial tissue can be imaged by multiple angles and multiple sections.
Preferably, each time the position information of the probe is adjusted, the imaging parameters of the multi-modal ultrasound signal acquisition need to be adaptively adjusted, so as to achieve a better imaging effect at different positions. The imaging parameters include imaging depth, excitation voltage, transmit pulse length, transmit receive delay.
106. And carrying out data processing on the ultrasonic signals under different position information, and acquiring the dynamic tissue displacement, strain and elastic tissue modulus information of each region to be observed in an acquisition period by combining a time sequence, and finally obtaining the heart cavity tissue characteristics in the heart cavity.
The heart cavity tissue characteristics are four-dimensional mechanical characteristics in nature, and specifically include: the change of the three-dimensional characteristics of the interior of the heart chamber with time in each heartbeat cycle; three-dimensional characteristics include, but are not limited to, three-dimensional cardiac chamber structure, myocardial tissue displacement, strain, and elastic wave velocity distribution, among others. Thus. The heart cavity tissue characteristics finally obtained by the embodiment comprise: the change of the three-dimensional heart chamber structure, the myocardial tissue displacement, the strain and the elastic wave velocity distribution in the heart chamber along with the time in each heart beat period.
The acquisition process of the heart cavity tissue characteristics comprises the following steps:
10601. processing data of ultrasonic signals acquired by the probe under different position information in a single acquisition cycle to obtain first tissue information data about tissue dynamic displacement and strain and second tissue information data about tissue elastic modulus;
10602. based on the first tissue information data and the second tissue information data, the dynamic tissue displacement, strain and elastic modulus information of each region to be observed in an acquisition period can be acquired, and the time sequence of multi-mode ultrasonic signal acquisition is combined to obtain the tissue displacement, strain and elastic wave velocity information of different regions to be observed which change along with time in an acquisition period;
10603. and converting the tissue displacement, strain and elastic wave velocity information to positions corresponding to the tissues in the heart chamber according to the corresponding position information to obtain the three-dimensional heart chamber structure, the myocardial tissue displacement, the strain and the elastic wave velocity distribution at different moments of the heartbeat cycle.
The first tissue information data is displacement and strain information estimated from a set of ultrasound image data by any method including, but not limited to, any method of processing that derives tissue displacement and/or deformation from acquired data. Preferably, the acquisition process of the first organization information data includes: respectively synthesizing data acquired by each single-frame image acquisition into a frame of ultrasonic B image, and sequencing according to the single-frame image acquisition sequence to acquire continuous multi-frame ultrasonic B images; estimating the relative tissue displacement between two adjacent frames of ultrasonic B images by a preset speckle tracking algorithm; selecting one frame from the ultrasonic B images of the multiple frames as a reference frame, and calculating the accumulated displacement of the ultrasonic B images of other frames relative to the reference frame; based on the relation between displacement and strain in mechanics, obtaining the accumulated strain of the ultrasonic B images of other frames relative to a reference frame; the accumulated displacement and the accumulated strain are taken as first organization information data. The first data processing includes, but is not limited to, any processing method that derives tissue displacement and/or deformation from the acquired data.
And calculating the elastic wave velocity and elasticity in the region to be observed according to the ultrasonic signal acquired by each transient elastic information acquisition to obtain second tissue information data. For transient elastic information acquisition, the elastic wave velocity and (viscoelasticity) of the tissue in the region to be observed can be calculated by each acquisition. Methods of data processing include, but are not limited to, any method of deriving elasticity or viscoelasticity of the observed tissue or material from shear wave properties. For transient elastic information acquisition, the elastic wave velocity and (viscoelasticity) of the tissue in the region to be observed can be calculated by each acquisition.
And arranging the first tissue information data and the second tissue information data according to a time sequence to obtain a two-dimensional tissue displacement, a strain diagram, an elastic wave velocity diagram and a (visco) elasticity diagram of the region to be observed along with the change of time in an acquisition cycle. And converting the obtained two-dimensional tissue displacement, strain diagram and elastic wave velocity (or visco-elasticity) diagram into a position corresponding to the heart tissue according to the recorded corresponding transducer position information (including angles), so as to obtain the heart chamber structure, the myocardial tissue displacement, the strain and the elastic wave velocity (or visco-elasticity) distribution in the three-dimensional space at different periods of the heartbeat.
In the embodiment, the heart tissue is scanned in different regions by adjusting the position of the probe and the position information is recorded, and then the distribution of the heart chamber structure, the myocardial tissue displacement, the strain and the elastic wave velocity (or viscoelasticity) in the three-dimensional space is obtained through reconstruction.
Compared with the ARFI elastography in the prior art which only gives the relative hardness between tissues, the intracardiac multi-mode ultrasonic imaging method of the embodiment can measure the elastic modulus of the tissues by utilizing shear wave elastography, and is more favorable for clinical diagnosis. Due to the special imaging sequence design, strain and shear wave elasticity imaging can be simultaneously carried out on the tissue through one-time acquisition sequence, so that the related information of strain, elasticity, nonlinearity and the like of the heart tissue at any time or state can be measured.
In addition, the multi-modality ultrasonic imaging method in the cardiac chamber of the embodiment can also be used for measuring mechanical parameters of a blood vessel wall or other organ chambers and wall soft tissues with tube-shaped and cavity-shaped structures.
The embodiment provides a multi-modal ultrasound imaging method in a heart cavity, which utilizes an ICE (internal Combustion Engine) ultrasonic probe catheter to perform four-dimensional multi-modal imaging and mechanical parameter measurement on heart tissues and can accurately obtain the characteristics of the heart cavity tissues in the heart cavity. The scheme of the embodiment not only can perform multi-mode ultrasonic imaging from the inside of the heart, but also can realize mechanical property measurement of heart tissues. Through shear wave elasticity imaging, the elastic modulus of the tissue can be measured; through strain imaging, information related to dynamic strain and displacement of tissue can be measured. Through multi-time multi-mode ultrasonic imaging acquisition, multi-angle multi-section data acquisition can be carried out on the same or different positions in the heart cavity, information in the heart cavity can be acquired more comprehensively, and diagnosis is facilitated. The ultrasonic strain imaging and the shear wave elastic imaging can be simultaneously carried out on the heart tissue through one-time acquisition sequence, the independent imaging is not needed, the relevant information such as the dynamic strain, the elastic modulus and the like of the tissue at any time or under a stress state can be measured, and the clinical diagnosis is facilitated.
Example 2
The embodiment provides a multi-modality ultrasonic imaging device in a cardiac chamber, which systematizes the method of embodiment 1, and the structural schematic diagram of the system is shown in the attached figure 3 of the specification, and the specific scheme is as follows:
an intracardiac multi-modality ultrasound imaging apparatus, comprising:
detection unit a 1: the ultrasonic imaging catheter is used for inserting the ultrasonic imaging catheter connected with the probe into a heart cavity along a blood vessel and carrying out real-time B-mode imaging on the inner part of the heart cavity;
area acquisition unit a 2: the device is used for adjusting the position of the probe and acquiring a region to be observed and position information corresponding to the probe;
period setting unit a 3: the system is used for setting an acquisition cycle for presetting multi-mode ultrasonic signal acquisition, and takes a certain moment in a heartbeat cycle as an acquisition starting moment, wherein the acquisition starting moment has a specific signal form in an ECG signal;
multi-modal unit a 4: the system is used for starting to carry out multi-mode ultrasonic signal acquisition on a region to be observed when the signal form in the real-time ECG signal of the detected individual is detected, and obtaining and storing the ultrasonic signal acquired by the probe under the position information;
the region adjusting unit A5 is used for adjusting the position information of the probe, replacing the region to be observed and carrying out multi-mode ultrasonic signal acquisition again to obtain the ultrasonic signals acquired by the probe in the same or different position information in the heart cavity;
and the data processing unit A6 is used for carrying out data processing on the ultrasonic signals under the position information and acquiring the heart cavity tissue characteristics of each region to be observed in the acquisition cycle by combining the time sequence.
Wherein, the multi-modal unit A4 specifically comprises:
when multi-mode ultrasonic signal acquisition is carried out, ultrasonic signals are transmitted according to a preset sequence, and single-frame image acquisition for ultrasonic strain imaging and transient elastic information acquisition for shear wave elastic imaging are carried out on tissues of a region to be observed in a penetrating mode according to a preset sequence, so that first signal data related to ultrasonic strain imaging and second signal data related to shear wave elastic imaging are obtained.
The embodiment provides a multi-mode ultrasonic imaging device in a heart chamber, and the method in the embodiment 1 is systematized to be more practical.
Example 3
The present embodiment provides a multi-modality ultrasound imaging system in a cardiac chamber, which is used for implementing the multi-modality ultrasound imaging method in the cardiac chamber of embodiment 1, and a structural schematic diagram of the system is shown in fig. 2 of the specification, and a specific scheme is as follows:
an intracardiac multi-modality ultrasound imaging system comprising:
the ultrasonic imaging catheter subsystem 1 comprises a probe 11 and an ultrasonic imaging catheter 12 which are connected with each other, wherein the probe 11 is provided with an ultrasonic transducer 111 and a positioning device 112, and is used for inserting the ultrasonic imaging catheter 12 and the probe 11 into a heart cavity along a blood vessel and carrying out real-time B-mode imaging on the interior of the heart cavity by transmitting and receiving signals through the ultrasonic transducer 111; the probe 11 is further provided with a positioning device 112, and the positioning device 112 is used for positioning the position and the azimuth angle of the ultrasonic transducer 111;
the ultrasonic imaging catheter 12 is connected with a steering control mechanism 13, and the steering control mechanism 13 can control the deflection of the position and the angle of the ultrasonic imaging catheter. The ultrasound imaging catheter subsystem 1 is connected to other devices through a connection plug 14.
The multi-mode ultrasonic imaging subsystem 2 is respectively connected with the ultrasonic imaging catheter subsystem 1 and the ECG acquisition and storage subsystem and is used for controlling the ultrasonic transducer 111 to transmit and receive ultrasonic signals and controlling the conversion, storage, processing and image display of the ultrasonic signals;
and a positioning subsystem 3 for positioning the position, azimuth angle, etc. of the ultrasonic transducer 111.
And the ECG acquisition and storage subsystem 4 is used for acquiring and storing the electrocardiosignals in real time.
The invention provides a method, a device and a system for multi-modal ultrasonic imaging in a heart cavity, which are used for carrying out four-dimensional multi-modal imaging and mechanical parameter measurement on heart tissues by utilizing an ICE ultrasonic probe catheter and can accurately obtain the characteristics of the heart cavity tissues in the heart cavity. The scheme of the invention not only can carry out multi-mode ultrasonic imaging from the inside of the heart, but also can realize the measurement of the mechanical properties of the heart tissue. Through shear wave elasticity imaging, the elastic modulus of the tissue can be measured; through strain imaging, information related to dynamic strain and displacement of tissue can be measured. Through multi-time multi-mode ultrasonic imaging acquisition, multi-angle multi-section data acquisition can be carried out on the same or different positions in the heart cavity, information in the heart cavity can be acquired more comprehensively, and diagnosis is facilitated. The ultrasonic strain imaging and the shear wave elastic imaging can be simultaneously carried out on the heart tissue through one-time acquisition sequence, the independent imaging is not needed, the relevant information such as the dynamic strain, the elastic modulus and the like of the tissue at any time or under a stress state can be measured, and the clinical diagnosis is facilitated.
It will be appreciated by those of ordinary skill in the art that the modules of the present invention described above may be implemented using a general purpose computing system, they may be centralized on a single computing system or distributed across a network of computing systems, and alternatively, they may be implemented using program code executable by a computing system, such that it may be stored in a memory system and executed by a computing system, or fabricated separately as individual integrated circuit modules, or fabricated as a single integrated circuit module from a plurality of modules or steps within them. Thus, the present invention is not limited to any specific combination of hardware and software.
It is to be noted that the foregoing is only illustrative of the preferred embodiments of the present invention and the technical principles employed. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments illustrated herein, but is capable of various obvious changes, rearrangements and substitutions as will now become apparent to those skilled in the art without departing from the scope of the invention. Therefore, although the present invention has been described in greater detail by the above embodiments, the present invention is not limited to the above embodiments, and may include other equivalent embodiments without departing from the spirit of the present invention, and the scope of the present invention is determined by the scope of the appended claims.
The above disclosure is only a few specific implementation scenarios of the present invention, however, the present invention is not limited thereto, and any variations that can be made by those skilled in the art are intended to fall within the scope of the present invention.

Claims (10)

1. A multi-mode ultrasonic imaging method in a heart chamber is characterized by comprising the following steps:
inserting the ultrasonic imaging catheter connected with the probe into a heart cavity along a blood vessel, and carrying out real-time B-mode imaging on the inner part of the heart cavity;
adjusting the position of the probe to obtain a region to be observed and position information corresponding to the probe;
setting an acquisition cycle of preset multi-mode ultrasonic signal acquisition, and taking a certain moment in a heartbeat cycle as an acquisition starting moment, wherein the acquisition starting moment has a specific signal form in an ECG signal;
when the signal form in the real-time ECG signal of the detected individual is detected, the multi-mode ultrasonic signal acquisition is started to be carried out on the area to be observed, and the ultrasonic signal acquired by the probe under the position information is obtained and stored;
adjusting the position information of the probe, replacing the region to be observed, and performing the multi-mode ultrasonic signal acquisition again to obtain the ultrasonic signals acquired by the probe in the same or different position information in the heart cavity;
and carrying out data processing on the ultrasonic signals under each position information, and acquiring the heart cavity tissue characteristics of each region to be observed in an acquisition period by combining a time sequence.
2. The intracardiac multimodal ultrasound imaging method according to claim 1, wherein said cardiac tissue properties comprise: the change of the three-dimensional heart chamber structure, the myocardial tissue displacement, the strain and the elastic wave velocity distribution in the heart chamber along with the time in each heart beat period.
3. The intracardiac multimodal ultrasound imaging method according to claim 2, wherein the acquisition of the tissue properties of the cardiac chamber comprises:
processing data of ultrasonic signals acquired by the probe under different position information in a single acquisition cycle to obtain first tissue information data about dynamic displacement and strain of tissue and second tissue information data about elasticity of the tissue;
based on the first tissue information data and the second tissue information data, combining the time sequence of the multi-mode ultrasonic signal acquisition to obtain tissue displacement, strain and elastic wave speed information of different regions to be observed changing along with time in an acquisition cycle;
and converting the tissue displacement, the strain and the elastic wave velocity information into positions corresponding to the heart cavity tissue during signal acquisition according to corresponding probe position information and imaging parameters to obtain the three-dimensional characteristics of the heart cavity tissue at different moments of the heartbeat cycle.
4. The intracardiac multimodal ultrasound imaging method according to claim 1, wherein the multimodal ultrasound signal acquisition in particular comprises:
transmitting ultrasonic signals according to a preset sequence, and alternately acquiring a single-frame image for ultrasonic strain imaging and transient elastic information for shear wave elastography according to a preset sequence on tissues of a region to be observed to obtain first signal data related to the ultrasonic strain imaging and second signal data related to the shear wave elastography.
5. The intracardiac multimodality ultrasound imaging method according to claim 4, wherein the interspersing, in a preset order, the single-frame image acquisition for ultrasound strain imaging and the transient elasticity information acquisition for shear wave elastography of the tissue of the region to be observed to obtain the first signal data about the ultrasound strain imaging and the second signal data about the shear wave elastography specifically comprises:
firstly, acquiring a first single-frame image, and immediately acquiring transient elastic information of the area to be observed after the acquisition of the first single-frame image is finished; or, first transient elastic information acquisition is carried out, and after the first transient elastic information acquisition is finished, first single-frame image acquisition is carried out on the region to be observed immediately;
after the first transient elastic information acquisition and the first single-frame image acquisition are finished, acquiring each subsequent single-frame image about ultrasonic strain imaging by taking the first single-frame image acquisition as a starting point according to a preset first acquisition frequency, and acquiring transient elastic information about shear wave elastic imaging at a subsequent moment by taking the first transient elastic information acquisition as a starting point according to a preset second acquisition frequency;
when the single-frame image acquisition is completed at the first acquisition frequency and the transient elastic information acquisition is completed at the second acquisition frequency, the ultrasonic signal acquisition of one acquisition period can be realized.
6. The intracardiac multimodal ultrasound imaging method according to claim 1, wherein when the multimodal ultrasound signal acquisition starts, the position information of the probe is synchronously acquired and recorded;
constructing a spatial coordinate system about the heart chamber based on the position information to describe a specific position of the probe within the heart chamber;
the position information comprises position coordinates of the probe in the heart cavity and an azimuth angle of the probe, the probe is provided with a positioning device, and the position information of the probe is determined through the positioning device.
7. The intracardiac multimodal ultrasound imaging method according to claim 4, wherein the acquisition period is not less than one complete cardiac cycle;
the time interval between two adjacent single-frame image acquisition is not more than the time interval between two adjacent transient elastic information acquisition;
the time interval between two adjacent single-frame image acquisition is not less than the acquisition time of one transient elastic information acquisition.
8. A multi-modality ultrasonic imaging device in a cardiac chamber is characterized by comprising,
a detection unit: the ultrasonic imaging catheter is used for inserting the ultrasonic imaging catheter connected with the probe into a heart cavity along a blood vessel and carrying out real-time B-mode imaging on the inner part of the heart cavity;
an area acquisition unit: the device is used for adjusting the position of the probe and acquiring a region to be observed and position information corresponding to the probe;
a cycle setting unit: the system is used for setting a preset multi-mode ultrasonic signal acquisition period, and takes a certain moment in a heartbeat period as an acquisition starting moment, wherein the acquisition starting moment has a specific signal form in an ECG signal;
a multi-modality unit: the system is used for starting to carry out the multi-mode ultrasonic signal acquisition on a region to be observed when the signal form in the real-time ECG signal of the detected individual is detected, and obtaining and storing the ultrasonic signal acquired by the probe under the position information;
the region adjusting unit is used for adjusting the position information of the probe, replacing a region to be observed and carrying out multi-mode ultrasonic signal acquisition again so as to obtain ultrasonic signals acquired by the probe under the same or different position information in the heart cavity;
and the data processing unit is used for carrying out data processing on the ultrasonic signals under the information of each position and acquiring the cardiac cavity tissue characteristics of each region to be observed in the acquisition period by combining the time sequence.
9. The intracardiac multimodal ultrasound imaging apparatus according to claim 8, wherein the multimodal unit in particular comprises:
when multi-mode ultrasonic signal acquisition is carried out, ultrasonic signals are transmitted according to a preset sequence, and single-frame image acquisition for ultrasonic strain imaging and transient elastic information acquisition for shear wave elastic imaging are carried out on tissues of a region to be observed in a penetrating mode according to a preset sequence, so that first signal data related to the ultrasonic strain imaging and second signal data related to the shear wave elastic imaging are obtained.
10. An intracardiac multi-modality ultrasound imaging system for carrying out the intracardiac multi-modality ultrasound imaging method according to any one of claims 1 to 7, the system comprising:
the ultrasonic imaging catheter subsystem comprises a probe and an ultrasonic imaging catheter which are connected with each other, wherein an ultrasonic transducer and a positioning device are arranged on the probe and used for inserting the ultrasonic imaging catheter and the probe into a heart cavity along a blood vessel, carrying out real-time B-mode imaging on the interior of the heart cavity by transmitting and receiving signals through the ultrasonic transducer, and positioning the ultrasonic transducer through the positioning device;
the ECG acquisition and storage subsystem is used for acquiring and storing the electrocardiosignals in real time;
the multi-mode ultrasonic imaging subsystem is respectively connected with the ultrasonic imaging catheter subsystem and the ECG acquisition and storage subsystem and is used for controlling the ultrasonic transducer to transmit and receive ultrasonic signals and controlling the conversion, storage, processing and image display of the ultrasonic signals;
and the positioning subsystem is used for acquiring the position information of the ultrasonic transducer.
CN202210379186.0A 2022-04-12 2022-04-12 Multi-mode ultrasonic imaging method, device and system in heart cavity Pending CN114748103A (en)

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CN115836879A (en) * 2022-12-29 2023-03-24 苏州诺莱声科技有限公司 Ultrasonic control system and method in heart cavity
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