CN114740921A - Thawing control system for biological sample and control method thereof - Google Patents
Thawing control system for biological sample and control method thereof Download PDFInfo
- Publication number
- CN114740921A CN114740921A CN202210389417.6A CN202210389417A CN114740921A CN 114740921 A CN114740921 A CN 114740921A CN 202210389417 A CN202210389417 A CN 202210389417A CN 114740921 A CN114740921 A CN 114740921A
- Authority
- CN
- China
- Prior art keywords
- temperature
- lower computer
- heating
- heating rod
- electric module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D23/00—Control of temperature
- G05D23/19—Control of temperature characterised by the use of electric means
- G05D23/20—Control of temperature characterised by the use of electric means with sensing elements having variation of electric or magnetic properties with change of temperature
- G05D23/24—Control of temperature characterised by the use of electric means with sensing elements having variation of electric or magnetic properties with change of temperature the sensing element having a resistance varying with temperature, e.g. a thermistor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Automation & Control Theory (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Freezing, Cooling And Drying Of Foods (AREA)
Abstract
The invention discloses a thawing control system for biological samples, which comprises an upper industrial personal computer, a lower computer, a thermistor, an electric module, an IR temperature sensor, a communication module and a heating rod, wherein the thermistor is used for collecting the temperature of a metal block, the heating rod is used for heating, the electric mode is provided with an automatic adjusting mode, the IR temperature sensor is used for measuring the temperature of a sample, the upper industrial personal computer is provided with configuration software, and the upper industrial personal computer is connected with the lower computer through RS 485; the lower computer is connected with the thermistor, the IR temperature sensor, the electric module and the heating rod. In the implementation process of the invention, the accurate control and real-time detection of the heating process of the biological sample are realized through the optimized control strategy, the defects caused by a water bath method are completely avoided, the unfreezing standardization of the biological sample is realized, the control strategy can be further put into GMP and clinical application through SOP, the problems of pain points and difficulties in the prior art are practically solved, and the method has important significance for the development of the biological industry.
Description
Technical Field
The invention belongs to the technical field of biological sample thawing, and particularly relates to a thawing control system for a biological sample and a control method thereof.
Background
Cryopreservation has become a valuable technique for the routine manipulation of cells and tissues in the field of bioscience. In many areas, such as biological sample banks, cell therapy, cell-based drug discovery, assisted reproduction, and other cell-based assays, can benefit from standardized cell thawing to increase their productivity and help them fulfill their mission of improving human health.
To achieve rapid thawing, biologists typically immerse frozen samples in water at various temperatures (from 37 ℃ to 0 ℃) for seconds to minutes. To date, the most common and widely accepted method of rapidly thawing cryopreserved biological samples is to partially submerge a cryopreserved tube-like container in a 37 ℃ water bath. However, thawing using a water bath has significant disadvantages. These disadvantages include: (1) water wicks into the cap threads and is sealed in a poorly maintained water bath, making the possibility of contamination of the contents of the container extremely high, (2) the inability to use the water bath as part of the aseptic process, (3) the large subjective differences in determining thaw time, final temperature, and endpoint among different users, and (4) the limitations of using water baths in GMP or clinical settings.
The important disadvantage is that the artificial thawing has too much subjective judgment, and the thawing process cannot be accurately controlled. With the development of the biological industry, technicians have higher and higher requirements on automation and controllability, so the invention of the thawing control system and the control method of the biological sample has important significance for the development of the biological industry.
Disclosure of Invention
In view of the above situation, in order to overcome the defects of the prior art, the present invention provides a thawing control system for biological samples and a control method thereof, which effectively solve the problems in the background art.
In order to achieve the purpose, the invention provides the following technical scheme: a thawing control system for biological samples comprises an upper industrial personal computer, a lower computer, a thermistor, an electric module, an IR temperature sensor, a communication module and a heating rod, wherein the thermistor is used for collecting the temperature of a metal block, the heating rod is used for heating, the electric module is provided with an automatic adjusting mode, the IR temperature sensor is used for measuring the temperature of a sample, configuration software is installed on the upper industrial personal computer, and the upper industrial personal computer is connected with the lower computer through RS 485; the lower computer is connected with the thermistor, the IR temperature sensor, the electric module and the heating rod, the data of the thermistor and the IR temperature sensor, the working state of the electric module and the working state of the heating rod are collected by the lower computer and transmitted to the upper computer, the upper computer carries out comprehensive processing according to the data of the thermistor and the IR temperature sensor, the working state of the electric module and the working state of the heating rod and configuration software, an instruction is sent to the lower computer, and the heating rod and the electric module are controlled through the lower computer.
In order to achieve the above purpose, the invention also provides the following technical scheme: a thawing control method for biological samples comprises the following steps of initializing system parameters, collecting initial data, starting a heating rod to enter a heating/stopping heating mode, starting an electric module to enter an automatic adjusting mode, starting an IR infrared sensor to enter a sample temperature measuring mode, detecting the temperature of a metal block through a thermistor, and starting the heating rod to execute a heating control program.
Preferably, the control program includes the steps of: initializing parameters, acquiring thermistor parameters, converting the thermistor parameters into real-time temperature, determining a value according to a difference value between the process set temperature and the real-time temperature, executing an output step when the value is greater than a dead zone, and finishing delaying to the next stage when the value is not greater than the dead zone or the value output step is finished;
meanwhile, the state of the electric module is collected, and the electric module is adjusted to be in an opening and closing state;
after the initialization phase is finished, the program enters the next control process, and the process comprises the following steps: the method comprises the steps that a biological sample is placed in a sample groove in a metal block, an IR temperature sensor collects the temperature of the sample in real time and transmits the data to a lower computer, the lower computer controls a heating rod to heat the metal block, the temperature of the sample in the heating process is detected by the IR temperature sensor in real time, the lower computer transmits the data to an upper computer in real time through an RS485 communication interface, and when the temperature reaches the temperature set by a program, an electric program control module enables the metal block to be separated from the biological sample and then enters the next period.
Preferably, the control process of the heating rod comprises the following steps: in the initialization stage, thermistor parameters are collected and converted into real-time temperature, the real-time temperature is uploaded to a lower computer, the lower computer controls a heating rod to heat according to program setting, and heating is stopped when the temperature is heated to the set initial temperature; and in the sample thawing stage, the heating rod executes a heating/heating stopping command according to the instruction of the lower computer until the next period.
Preferably, the control process of the electric module includes the steps of: in the initialization stage, the electric module enters an opening and closing state according to a lower computer program; and in the biological sample thawing stage, the upper computer transmits an operation instruction to the lower computer, the lower computer controls the electric module to enter a closed state until the thawing process is completed, and the electric module returns to an open-close state to enter the next period.
Preferably, in the initialization stage, the heating program of the heating rod is determined by the built-in function of the lower computer, and the metal block connected with the heating rod is heated to the set temperature.
Compared with the prior art, the invention has the beneficial effects that:
by the optimized control strategy, the accurate control and real-time detection of the heating process of the biological sample are realized, the defects caused by a water bath method are completely avoided, the unfreezing standardization of the biological sample is realized, the control strategy can be further subjected to SOP (system on the plate) and clinical application, the problems of pain and difficulty in the prior art are practically solved, and the control strategy has important significance for the development of the biological industry; and is particularly suitable for the dry anhydrous biological sample and the thawing of the temperature sensitive biological sample in the implementation process of the invention.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic diagram of the system of the present invention;
FIG. 2 is a flowchart of the operation of the motorized module and IR temperature sensor of the present invention;
FIG. 3 is a flow chart of the thermistor and heater rod control of the present invention.
In the figure: 1, an upper computer; 2, a lower computer; 3, a thermistor; 4, heating a rod; 5, an electric module; 6, an IR temperature sensor; 7, a metal block; and 8, sampling.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments; all other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
The invention discloses a thawing control system for biological samples, which comprises an upper industrial personal computer, a lower computer, a thermistor, an electric module, an IR temperature sensor, a communication module and a heating rod, wherein the thermistor is used for collecting the temperature of a metal block, the heating rod is used for heating, the electric module is provided with an automatic adjusting mode, the IR temperature sensor is used for measuring the temperature of a sample, the upper industrial personal computer is provided with configuration software, and the upper industrial personal computer is connected with the lower computer through RS 485; the lower computer is connected with the thermistor, the IR temperature sensor, the electric module and the heating rod, the data of the thermistor and the IR temperature sensor, the working state of the electric module and the working state of the heating rod are collected by the lower computer and transmitted to the upper computer, the upper computer carries out comprehensive processing according to the data of the thermistor and the IR temperature sensor, the working state of the electric module and the heating rod and configuration software, and sends instructions to the lower computer, and the heating rod and the electric module are controlled through the lower computer.
A thawing control method for biological samples comprises the following steps of initializing system parameters, collecting initial data, starting a heating rod to enter a heating/stopping heating mode, starting an electric module to enter an automatic adjusting mode, starting an IR infrared sensor to enter a sample temperature measuring mode, detecting the temperature of a metal block through a thermistor, and starting the heating rod to execute a heating control program.
The control program includes the steps of: initializing parameters, acquiring thermistor parameters, converting the thermistor parameters into real-time temperature, determining a value according to a difference value between the process set temperature and the real-time temperature, executing an output step when the value is greater than a dead zone, and finishing delaying to the next stage when the value is not greater than the dead zone or the value output step is finished;
meanwhile, the state of the electric module is collected, and the electric module is adjusted to be in an opening and closing state;
after the initialization phase is finished, the program enters the next control process, and the process comprises the following steps: the method comprises the steps that a biological sample is placed in a sample groove in a metal block, an IR temperature sensor collects the temperature of the sample in real time and transmits data to a lower computer, the lower computer controls a heating rod to heat the metal block, the temperature of the sample in the heating process is detected by the IR temperature sensor in real time, the lower computer transmits the data to an upper computer in real time through an RS485 communication interface, and when the temperature reaches the temperature set by a program, the program controls an electric module to enable the metal block to be separated from the biological sample, and then the next period is started.
The control process of the heating rod comprises the following steps: in the initialization stage, thermistor parameters are collected and converted into real-time temperature, the real-time temperature is uploaded to a lower computer, the lower computer controls a heating rod to heat according to program setting, and heating is stopped when the temperature is heated to the set initial temperature; and in the sample thawing stage, the heating rod executes a heating/heating stopping command according to the instruction of the lower computer until the next period.
The control process of the electric module comprises the following steps: in the initialization stage, the electric module enters an opening and closing state according to a lower computer program; and in the biological sample thawing stage, the upper computer transmits an operation instruction to the lower computer, the lower computer controls the electric module to enter a closed state until the thawing process is completed, and the electric module returns to an open-close state and enters the next period.
And in the initialization stage, the heating program of the heating rod is determined by a lower built-in function, and the metal block connected with the heating rod is heated to a preset temperature.
The system comprises an upper industrial personal computer 1 with installed configuration software, a lower computer 2, a thermistor 3, a heating rod 4 and a control system, wherein the upper industrial personal computer 1 is connected with the lower computer 2 through RS 485; meanwhile, the lower computer 2 transmits a command to the electric module 5, and the electric module 5 controls the opening and closing of the metal block 7; after a biological sample 8 is placed in a metal block 7, an instruction is transmitted to an electric module 5 and an IR temperature sensor 6 by an upper computer 1 through a lower computer 2, the electric module 5 controls the metal block 7 to be closed, the IR temperature sensor 6 detects the temperature of the sample 8 in real time and transmits temperature parameters to the upper computer 1 through the lower computer 2 via RS485, a control program of the upper computer displays the temperature curve of the sample 8 in real time, when the temperature of the sample 8 reaches a temperature value preset by the program, the upper computer 1 transmits the instruction to the electric module 5 and the IR temperature sensor 6 through the lower computer 2, the electric module 5 controls the metal block 7 to be opened and closed, and the IR temperature sensor 6 stops recording data; in the process, the thermistor 3 and the heating rod 4 receive the instruction of the lower computer 2 and work continuously according to the program until the next period is started.
The upper industrial personal computer 1 comprehensively monitors the system, displays the system in real time in running configuration software, and comprises time, temperature, electric module state and the like, and records a sample thawing curve in real time in the configuration software, and records sample numbers so as to facilitate later-stage query and analysis.
The lower computer is connected with the upper computer through RS485, and simultaneously, the lower computer is connected with the thermistor, the electric module, the IR temperature sensor and the heating rod.
The thermistor is an NTC type resistor.
The electric module is driven by a direct current brushless motor.
The IR temperature sensor is an ADC type infrared sensor.
The heating rod is a resistance type heating rod.
During operation, the lower computer adjusts whether the heating rod works or not through the temperature detected by the thermistor, and the work station where the electric module is located is controlled through the instruction of the upper computer. According to the process requirements, the IR infrared sensor collects temperature signals of the thawed biological samples in real time and transmits the temperature signals to the upper computer through the lower computer, so that the thawing condition of the samples is judged in real time, and the purpose of accurately controlling the thawing process is achieved.
The program comprises a sample thawing curve control program, a thermistor heating control program and an electric module control program. I.e., a sequence or combination of steps performed in a prescribed order.
The metal block is provided with 2 thermistors and 2 heating rods.
The technical scheme adopted by the invention for solving the technical problems also comprises a control method, which comprises the following steps: initializing system parameters, collecting metal block data through a thermistor, starting a heating rod control program, starting an electric module control program, and starting a sample thawing curve control program.
The control process of the heating rod comprises the following steps: in the initialization stage, thermistor parameters are collected and converted into real-time temperature, the real-time temperature is uploaded to a lower computer, the lower computer controls a heating rod to heat according to program setting, and heating is stopped when the temperature is heated to the set initial temperature; and in the sample thawing stage, the heating rod executes a heating/heating stopping command according to the instruction of the lower computer until the next period.
The control process of the electric module comprises the following steps: in the initialization stage, the electric module enters an opening and closing state according to a lower computer program; and in the biological sample thawing stage, the upper computer transmits an operation instruction to the lower computer, the lower computer controls the electric module to enter a closed state until the thawing process is completed, and the electric module returns to an open-close state and enters the next period.
In the initialization stage, the heating program of the heating rod is determined by a built-in function of the lower computer, and the metal block connected with the heating rod is heated to a preset temperature; the electric module is in an opening and closing state.
The time used in the initialization phase of the invention is set to 180-.
The output force of the electric module is 5-30N.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. A thaw control system for a biological sample, characterized by: the device comprises an upper industrial personal computer, a lower computer, a thermistor, an electric module, an IR temperature sensor, a communication module and a heating rod, wherein the thermistor is used for collecting the temperature of a metal block, the heating rod is used for heating, the electric mode is provided with an automatic adjusting mode, the IR temperature sensor is used for measuring the temperature of a sample, the upper industrial personal computer is provided with configuration software, and the upper industrial personal computer is connected with the lower computer through RS 485; the lower computer is connected with the thermistor, the IR temperature sensor, the electric module and the heating rod, the data of the thermistor and the IR temperature sensor, the working state of the electric module and the working state of the heating rod are collected by the lower computer and transmitted to the upper computer, the upper computer carries out comprehensive processing according to the data of the thermistor and the IR temperature sensor, the working state of the electric module and the working state of the heating rod and configuration software, an instruction is sent to the lower computer, and the heating rod and the electric module are controlled through the lower computer.
2. The thawing control method for biological samples according to claim 1, wherein: the method comprises the following steps of initializing system parameters and acquiring initial data, starting a heating rod to enter a heating/stopping heating mode, starting an electric module to enter an automatic adjusting mode, starting an IR infrared sensor to enter a sample temperature measuring mode, detecting the temperature of a metal block through a thermistor, and starting the heating rod to execute a heating control program.
3. The thawing control method for biological samples according to claim 2, wherein: the control program includes the steps of: initializing parameters, acquiring thermistor parameters, converting the thermistor parameters into real-time temperature, determining a value according to a difference value between the process set temperature and the real-time temperature, executing an output step when the value is greater than a dead zone, and finishing delaying to the next stage when the value is not greater than the dead zone or the value output step is finished;
meanwhile, the state of the electric module is collected, and the electric module is adjusted to be in an opening and closing state;
after the initialization phase is finished, the program enters the next control process, and the process comprises the following steps: the method comprises the steps that a biological sample is placed in a sample groove in a metal block, an IR temperature sensor collects the temperature of the sample in real time and transmits the data to a lower computer, the lower computer controls a heating rod to heat the metal block, the temperature of the sample in the heating process is detected by the IR temperature sensor in real time, the lower computer transmits the data to an upper computer in real time through an RS485 communication interface, and when the temperature reaches the temperature set by a program, an electric program control module enables the metal block to be separated from the biological sample and then enters the next period.
4. A thawing control method for biological samples according to claim 3, characterized in that: the control process of the heating rod comprises the following steps: in the initialization stage, thermistor parameters are collected and converted into real-time temperature, the real-time temperature is uploaded to a lower computer, the lower computer controls a heating rod to heat according to program setting, and heating is stopped when the temperature is heated to the set initial temperature; and in the sample thawing stage, the heating rod executes a heating/heating stopping command according to the instruction of the lower computer until the next period.
5. A thawing control method for biological samples according to claim 3, characterized in that: the control process of the electric module comprises the following steps: in the initialization stage, the electric module enters an opening and closing state according to a lower computer program; and in the biological sample thawing stage, the upper computer transmits an operation instruction to the lower computer, the lower computer controls the electric module to enter a closed state until the thawing process is completed, and the electric module returns to an open-close state and enters the next period.
6. A thawing control method for biological samples according to claim 3, characterized in that: and in the initialization stage, the heating program of the heating rod is determined by the built-in function of the lower computer, and the metal block connected with the heating rod is heated to the temperature set by the upper computer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210389417.6A CN114740921A (en) | 2022-04-13 | 2022-04-13 | Thawing control system for biological sample and control method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210389417.6A CN114740921A (en) | 2022-04-13 | 2022-04-13 | Thawing control system for biological sample and control method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114740921A true CN114740921A (en) | 2022-07-12 |
Family
ID=82282267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210389417.6A Pending CN114740921A (en) | 2022-04-13 | 2022-04-13 | Thawing control system for biological sample and control method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114740921A (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120234817A1 (en) * | 2011-03-14 | 2012-09-20 | Products Support, Inc. | Thawing Oven |
| US20150125138A1 (en) * | 2012-10-31 | 2015-05-07 | Pluristem Ltd. | Method and device for thawing biological material |
| US20150334774A1 (en) * | 2014-05-16 | 2015-11-19 | Biocision, Llc | Systems, Devices, and Methods for Automated Sample Thawing |
| KR101777750B1 (en) * | 2016-03-17 | 2017-09-26 | 주식회사 우리메디칼 | Blood cell analyzer with specimen heating apparatus quality control method thereof |
| CN206741339U (en) * | 2017-06-01 | 2017-12-12 | 三峡大学 | A kind of quick accuracy-control system of Miniature biochemical analysis instrument sample detection room temperature |
| WO2018195107A1 (en) * | 2017-04-17 | 2018-10-25 | MedCision, Inc. | Systems, devices, and methods for automated large gauge sample thawing |
| US20190383554A1 (en) * | 2016-11-25 | 2019-12-19 | Asymptote Ltd. | Systems and Methods for Remotely Monitoring the Cryogenic Processing of Samples |
| CN111565850A (en) * | 2017-08-03 | 2020-08-21 | 比奥利弗解决方案公司 | System, apparatus and method for automated thawing of pouch-like storage containers |
| CN212077058U (en) * | 2019-12-30 | 2020-12-04 | 陕西麦可罗生物科技有限公司 | Fermentation cylinder temperature verification device |
| WO2021068373A1 (en) * | 2019-10-08 | 2021-04-15 | 苏州贝康医疗器械有限公司 | Automatic biological sample library |
-
2022
- 2022-04-13 CN CN202210389417.6A patent/CN114740921A/en active Pending
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120234817A1 (en) * | 2011-03-14 | 2012-09-20 | Products Support, Inc. | Thawing Oven |
| US20150125138A1 (en) * | 2012-10-31 | 2015-05-07 | Pluristem Ltd. | Method and device for thawing biological material |
| US20150334774A1 (en) * | 2014-05-16 | 2015-11-19 | Biocision, Llc | Systems, Devices, and Methods for Automated Sample Thawing |
| CN106455862A (en) * | 2014-05-16 | 2017-02-22 | 比奥新有限公司 | Systems, devices, and methods for automated sample thawing |
| KR101777750B1 (en) * | 2016-03-17 | 2017-09-26 | 주식회사 우리메디칼 | Blood cell analyzer with specimen heating apparatus quality control method thereof |
| US20190383554A1 (en) * | 2016-11-25 | 2019-12-19 | Asymptote Ltd. | Systems and Methods for Remotely Monitoring the Cryogenic Processing of Samples |
| CN111404984A (en) * | 2016-11-25 | 2020-07-10 | 阿西姆普托特有限公司 | System and method for remote monitoring of cryogenic processing of samples |
| WO2018195107A1 (en) * | 2017-04-17 | 2018-10-25 | MedCision, Inc. | Systems, devices, and methods for automated large gauge sample thawing |
| CN206741339U (en) * | 2017-06-01 | 2017-12-12 | 三峡大学 | A kind of quick accuracy-control system of Miniature biochemical analysis instrument sample detection room temperature |
| CN111565850A (en) * | 2017-08-03 | 2020-08-21 | 比奥利弗解决方案公司 | System, apparatus and method for automated thawing of pouch-like storage containers |
| WO2021068373A1 (en) * | 2019-10-08 | 2021-04-15 | 苏州贝康医疗器械有限公司 | Automatic biological sample library |
| CN212077058U (en) * | 2019-12-30 | 2020-12-04 | 陕西麦可罗生物科技有限公司 | Fermentation cylinder temperature verification device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2640427C2 (en) | Method and device of defrosting biomaterial | |
| CA2589844A1 (en) | Slide treatment apparatus and methods for use | |
| CN210322667U (en) | Multi-sample tobacco moisture rapid detection device | |
| CN114740921A (en) | Thawing control system for biological sample and control method thereof | |
| CN104881062B (en) | Quick and overregulation-free cooling crystallization reaction kettle temperature control method | |
| CN103091350A (en) | Rapid automatic phase-change material thermal cycle experiment instrument | |
| CN101310672B (en) | Method and system for performing infrared chart imaging to the target surface | |
| CN204429335U (en) | A kind of test-type constant temperature water bath | |
| CN114608932A (en) | Automatic thawing system for cryopreservation of biological samples | |
| CN114134033B (en) | PCR thermal cycling device and control method | |
| CN206057068U (en) | A kind of sample ashing device of fast heating intelligent temperature control | |
| CN212253404U (en) | Microwave vacuum drying equipment of on-line monitoring | |
| CN206875839U (en) | A kind of electric drying oven with forced convection | |
| CN208055404U (en) | A kind of quenching test machine | |
| CN216161026U (en) | Heat-preservation flip dry-type thermostat | |
| CN114184005B (en) | Drying device and method capable of judging primary and secondary drying critical points in freeze-drying process | |
| CN115016573B (en) | Carbon potential control method, system and device | |
| CN219442083U (en) | Constant-temperature centrifuge adapter and mounting structure thereof | |
| CN208554261U (en) | A kind of thermostat metal bath apparatus that stability is strong | |
| CN208661181U (en) | Heating device for blood preparation solidification | |
| CN220951827U (en) | Fermentation box capable of controlling internal temperature | |
| CN208254922U (en) | A kind of blood separating mechanism | |
| CN219092111U (en) | Constant-temperature water bath kettle with accurately-adjusted temperature zone | |
| JPH0527674U (en) | Reaction tank circulating water flow controller | |
| CN215140086U (en) | Digital display constant temperature water bath with high temperature control precision |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |