CN114712479B - 一种治疗小儿风寒感冒的药物及其制备方法与使用方法 - Google Patents
一种治疗小儿风寒感冒的药物及其制备方法与使用方法 Download PDFInfo
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Abstract
本发明公开了一种治疗小儿风寒感冒的药物,按质量计,由以下原料药组成:藿香30~60g,厚朴5~15g,陈皮20~50g,白芷20~50g,紫苏梗5~15g,茯苓皮20~50g,生姜10~35g,姜半夏30~60g,砂仁10~35g。其制备过程主要是通过文武火的煎煮后,得到药液,该药液即为所需药物,该药物为汤剂,具体使用时,将药物汤剂根据患儿年龄按比例加入温水中制成药浴,然后让患儿沐浴药浴,完成治疗过程。本发明根据临床治疗情况反馈,符合诊断标准的患儿应用该方药浴后,可显著改善高热不退、无汗、咳嗽痰多及气促等症状,无发热但有咳嗽、咳痰、头痛、流涕等症状的患儿,使用药浴后相关症状也有明显缓解,特别是散寒解表、祛痰、燥湿功效尤为显著,具有良好的市场前景,适宜广泛推广应用。
Description
技术领域
本发明涉及中药组方技术领域,具体是指一种治疗小儿风寒感冒的药物及其制备方法与使用方法。
背景技术
当代中药方剂多参照经典记载,根据辨证分型及现代人体质特点,实时调整药物组成和用量,可真正做到因人、因地、因时制宜的个性化治疗方案。用法多样,包括口服、外洗、熏蒸、膏药外敷等,针对不同疾病的不同症状具体运用,尽可能使给药途径和作用发挥相对直接,减少药物代谢损耗,保证治疗效率的提高。目前中医药治疗小儿外感风寒多以内治为主。但中药多味苦,儿童本能抗拒口服中药汤剂,故难以很好遵医嘱,导致治疗效果欠佳。
发明内容
本发明的目的在于提供一种可显著改善高热不退、无汗、咳嗽痰多及气促等症状,无发热但有咳嗽、咳痰、头痛、流涕等症状的治疗小儿风寒感冒的药物。
本发明另一个目的在于提供上述治疗小儿风寒感冒的药物的制备方法。
本发明还有个一个目的在于提供上述治疗小儿风寒感冒的药物的使用方法,该使用方法不受时间与地域的限制、利用温度适宜的环境促进患儿皮肤毛孔张开、汗液***,达到加速发汗退热的目的,同时使药物有效成分直接通过皮肤吸收,减少损耗,避免儿童因口服药物口感不佳拒遵医嘱。
本发明通过下述技术方案实现:一种治疗小儿风寒感冒的药物,按质量计,由以下原料药组成:藿香30~60g,厚朴5~15g,陈皮20~50g,白芷20~50g,紫苏梗5~15g,茯苓皮20~50g,生姜10~35g,姜半夏30~60g,砂仁10~35g。
为了优化本发明所述药物的治疗效果,进一步地限定各原料药的具体用量,按质量计,藿香45g,厚朴10g,陈皮30g,白芷30g,紫苏梗10g,茯苓皮35g,生姜20g,姜半夏45g,砂仁20g。
为了优化本发明所述药物的治疗效果,进一步地限定,所述藿香为广藿香,所述厚朴为姜厚朴。所述姜厚朴是通过厚朴丝照姜汁炙法炒干后制得。
本发明所述的一种治疗小儿风寒感冒的中药组方的中药学机理如下:
广藿香为全方中的君药,其性性温味辛、气芳香善辟秽;姜厚朴、姜半夏能温中燥湿,降逆止呕,为臣药;佐以白芷,其性辛温解表,提高藿香解表化湿作用;紫苏梗顺气宽中,陈皮味辛苦,可行气除湿邪,茯苓皮味甘性平、利水消肿,砂仁行气调中、和胃醒脾。全方表里同治,能解表散寒,芳香化浊,理气和中。
核心配方出自俞根初《通俗伤寒论》中的改良藿香正气汤,按原方单位“两”换算成当代国际单位“克”。参考多次煎煮后对提取物成分的测定结果,使用相当于处方量药材30倍的水时,迷迭香酸等抗炎镇痛退热等成分的含量最高。根据《中医护理常规技术操作规程》,中药汤剂用于药浴时需保证药液与清水按3:10左右比例配制浓度。根据《干预人群及目的选择中药饮片(九种体质及优势病种的中药选择参考附录B和C)》,疾病人群中药饮片最小用量为 260g,亚健康人群中药饮片最小用量230g,健康人群中药饮片最小用量200g。综合以上标准,并考虑实际运用时器材容积、儿童和成人用药量及药浴用水量等因素,本方中各药材剂量均为原方2倍。
中药组方主要特征为多组分与多靶点,复数药物中的有效成分互相配合或反应,可增强原有作用,治疗多病因多症状的复杂疾病效果显著。例如中药配伍方面,厚朴、半夏姜制后均加强燥湿止呕功效,相须为用,共同温中降逆止呕;陈皮行气、茯苓健脾,相须为用可加强燥湿利水祛痰功效;藿香、砂仁辛温芳香,白芷辛温祛风,砂仁、白芷可佐助君药藿香的解表化湿功效。而药理学方面,本方中广藿香、紫苏梗、生姜共有黄酮类化合物相配合,可全方位、有效抑制病毒、真菌、部分革兰氏阳性菌的繁殖;姜半夏和生姜含有的正丁醇提取物结合,可在抑制急性炎症的基础上,增加镇咳、祛痰功效;紫苏与白芷挥发油组合,可增强单味药物抑制组胺释放、降低毛细血管通透性的抗过敏作用。
其中,各原料药的药理如下:
广藿香:有多重有益的活性物质,其主要成分环索酮及广藿香醇均具有良好的抗病毒、抗炎等作用。紫苏梗含挥发油具有抗过敏作用,其中迷迭香酸具有较强的抗炎活性,同时与广藿香共有的黄酮类化合物可有效抑制病毒繁殖。
厚朴:具有燥湿消痰、下气除满的功效,其主要化学成分厚朴酚是一种糖皮质激素样非选择性抗炎药,能抑制器官组织细胞的炎性细胞因子表达,产生抗炎作用。厚朴和白芷除了通过抗炎作用产生疗效,还可以治疗某些伴随症状,作为臣药配合藿香提高汤剂药效。
陈皮:含有的挥发油类物质中,主要成分柠檬烯与蒎烯具有良好的镇咳、祛痰、抑菌作用,陈皮醇提取物对气管有较强的松弛作用。
白芷:具有解表散寒,祛风止痛等作用,其含有多种香豆素、挥发油等,白芷总挥发油(EOAD)具有抗过敏作用,可降低肥大细胞脱颗粒及毛细血管通透性,并抑制组胺释放;白芷香豆素类成分欧前胡素和异欧前胡素可与5- 羟色胺、乙酰胆碱、血栓素-***素等受体结合,通过介导痉挛、炎症等相关信号通路发挥镇痛作用,有良好的抗炎、抗菌作用。
紫苏梗:理气,舒郁,止痛,安胎。治气郁,食滞,胸膈痞闷,脘腹疼痛,胎气不和。
茯苓皮:煎液可镇静、利尿,其中茯苓多糖具有显著免疫调节作用,三萜类化合物具有解热、抗炎、镇痛、抗菌抗病毒等功效。
生姜:其正丁醇提取物中倍半萜类成分可有效抑制脂多糖诱导的巨噬细胞中硝酸还原酶产生,从而达到抑制急性炎症的作用,黄酮类成分则可抑制真菌及部分革兰氏阳性菌。
姜半夏:煎液中的有机酸及正丁醇提取物具显著镇咳、祛痰效果,半夏生物碱的糖皮质激素样作用可抑制炎症因子***素E2的产生和释放。
砂仁:其中的槲皮苷具有一定抗炎活性,主要表现为致炎性因子的抑制作用,且能显著抑制HSV2活性,强烈抑制流感病毒A/W3/33的感染作用,效果优于奥司他韦。
上述药物的制备方法,包括以下步骤:
(1)根据需求,称量原料药,先行用清水或纯净水浸泡30分钟;
(2)将浸泡后的中药原料药物及其浸泡的药水加入到煎药容器中,加盖共同煎煮,先用武火使煎药容器中药液沸腾,再使用文火熬制15~20分钟;
(3)滤出药液,所得药液即为治疗小儿风寒感冒的药物,所述治疗小儿风寒感冒的药物为汤剂。
上述药物的使用方法,取38℃~40℃的温水,根据患儿年龄差异,向每 3000mL温水中加入200~400mL药物汤剂制成药浴,将患儿浸泡在药浴中 10~15min,使患儿微微发汗即可。
其中,6个月-2岁的患儿浸泡的药浴为每3000mL温水中加入200mL药物汤剂制成的药浴,3-14岁的患儿浸泡的药浴为每3000mL温水中加入400mL 药物汤剂制成的药浴。
且患儿在浸泡药浴的前后,均需要多饮水,或进食适量含水分较多的食物。
本发明与现有技术相比,具有以下优点及有益效果:
(1)本发明以广藿香为全方中的君药,其性性温味辛、气芳香善辟秽;姜厚朴、姜半夏能温中燥湿,降逆止呕,为臣药;佐以白芷,其性辛温解表,提高藿香解表化湿作用;紫苏梗顺气宽中,陈皮味辛苦,可行气除湿邪,茯苓皮味甘性平、利水消肿,砂仁行气调中、和胃醒脾全方表里同治,能解表散寒,芳香化浊,理气和中;
(2)本发明提供药物以药浴进行治疗,不受时间与地域的限制,可在家中使用,利用温度适宜的环境促进患儿皮肤毛孔张开、汗液***,达到加速发汗退热的目的,同时使药物有效成分直接通过皮肤吸收,减少损耗,避免儿童因口服药物口感不佳拒遵医嘱;
(3)本发明根据临床治疗情况反馈,符合诊断标准的患儿应用该方药浴后,可显著改善高热不退、无汗、咳嗽痰多及气促等症状,无发热但有咳嗽、咳痰、头痛、流涕等症状的患儿,使用药浴后相关症状也有明显缓解,特别是散寒解表、祛痰、燥湿功效尤为显著,具有良好的市场前景,适宜广泛推广应用。
附图说明
通过阅读参照以下附图对非限制性实施例所作的详细描述,本发明的其他特征、目的和优点将会变得更为明显:
图1为患儿未使用本发明所述药物前的就诊病历图;
图2为患儿使用本发明所述药物四天后的就诊病历图;
图3为患儿使用本发明所述药物四天后的血常规报告图。
具体实施方式
为使本发明的目的、工艺条件及优点作用更加清楚明白,结合以下实施实例,对本发明作进一步详细说明,但本发明的实施方式不限于此,在不脱离本发明上述技术思想情况下,根据本领域普通技术知识和惯用手段,做出各种替换和变更,均应包括在本发明的范围内,此处所描述的具体实施实例仅用以解释本发明,并不用于限定本发明。
实施例1:
本实施例提供治疗小儿风寒感冒的药物,该药物由以下质量的原料药构成,广藿香45g,姜厚朴10g,陈皮30g,白芷30g,紫苏梗10g,茯苓皮35g,生姜20g,姜半夏45g,砂仁20g。
该药物为汤剂,具体制备过程如下:
(1)根据需求,称量原料药,先行用清水或纯净水浸泡30分钟;
(2)将浸泡后的中药原料药物及其浸泡的药水加入到煎药容器中,加盖共同煎煮,先用武火使煎药容器中药液沸腾,再使用文火熬制15~20分钟;
(3)滤出药液,所得药液即为治疗小儿风寒感冒的药物,所述治疗小儿风寒感冒的药物为汤剂。
上述煎药容器为砂锅、搪瓷器皿或者不锈钢,忌用铁器。
其具体使用方法为:
取38℃~40℃的温水,根据患儿年龄差异,向每3000mL温水中加入 200~400mL药物汤剂制成药浴,将患儿浸泡在药浴中10~15min,使患儿微微发汗即可。
其中,6个月-2岁的患儿浸泡的药浴为每3000mL温水中加入200mL药物汤剂制成的药浴,3-14岁的患儿浸泡的药浴为每3000mL温水中加入400mL 药物汤剂制成的药浴。
另外,患儿在浸泡药浴的前后,均需要多饮水,或进食适量含水分较多的食物。
实施例2:
本实施例提供使用治疗小儿风寒感冒的药物的临床统计学实验,具体如下:
发明人于2021年6月-12月筛选符合《中药新药临床研究指导原则》(试行)规定的“上呼吸道感染”,及国家中医药管理局《中医病证诊断疗效标准》 (1994年)小儿风寒感冒标准的6个月-14岁患儿共300例,其中男153例,女147例,随机分成两组(即常规组与观察组),每组各150例进行对照研究:两组均使用不含退热成分的基础药物治疗,此外,常规组予常规对症处理:即体温在38.5℃以下者,仅嘱多饮水及物理降温;体温超过38.5℃以上者,除嘱多饮水和物理降温外,给予口服退热药,服药6h后体温如再次超过38.5℃以上者,继续予退热药口服,每天不超过4次。
观察组除上述处理外,予以藿香正气水温水泡浴,方法:38℃-40℃左右的温水,6个月-2岁每3000mL水中加1包(200mL)藿香正气汤煎剂,3-14 岁每3000ml水中加2包(400ml)藿香正气汤煎剂,每次泡浴约10-15min,使患儿微微发汗即可。泡浴前后要多饮水,可适量进食含水份较多的食物。3 天后复诊,并分别记录经上述处理后1h,2h,3h,4h,24h的体温降温情况;以及临床症状改善情况和咽充血消失情况。
依据《外感发热疗效判定标准》判定疗效。
治愈:热尽身凉,且无反复,主要症状消失,异常理化检查指标恢复正常;
显效:发热已退且无反复,主要症状大部分消失,异常理化检查指标接近正常;
有效:发热已退,但还有反复,主要症状部分消失,异常理化检查指标有所改善;
无效:发热持续不退,症状无明显改善,异常理化检查指标无明显改善。
全部数据采用SPSS19.0软件进行统计学处理,计数资料采用卡方检验,计量资料用t检验,数据采用均数±标准差(±s)表示。
常规组在4h内降温人数132例,占88.00%;观察组在4h内降温人数142 例,占94.67%;两组比较,差异有统计学意义(t=4.57,P<0.01);
常规组咽充血有消退者为68.30%;观察组咽充血有消退者为95.00%,两组比较(t=3.72,P<0.01),具有统计学意义;
常规组显效率为51.67%;观察组显效率为90.00%;
常规组有效率为76.66%、观察组有效率为96.70%;
两组间治愈率、显效率、有效率比较t值分别为4.12、4.69和3.68;两组相比P<0.01具有统计学意义。
实施例3:
本实施例提供使用治疗小儿风寒感冒的药物进行治疗的典型病例,并提供例子1患者的病历情况(处于隐私考虑,涂去了患者姓名和医师姓名),如图1,图2所示,已经使用药物后,血常规检查情况,如图3所示。具体典型病历如下:
例1:吴某,男,6岁,因“咳嗽1周”就诊。初始咳嗽,晨起及睡前时明显,有痰难咳出,伴见咽红+,双扁桃体I°肿大,双肺呼吸音清,无啰音。用药5天后复诊,咳嗽缓解,痰可咳出,咽稍红,双肺呼吸音清,无啰音。
例2:孟某,男,5岁,因“咳嗽流鼻涕、鼻塞3天”就诊。初始咳嗽,痰多,伴鼻塞,流清涕,无发热,无喘息,无气促,无呼吸困难。用药5天后复诊,仍有咳嗽,有痰,鼻塞、流涕好转,无发热,无喘息,无气促,无呼吸困难。
例3:周某,男,7岁,因“发热1天”就诊。初始出现发热,最高体温 38.9摄氏度,无畏寒、寒战,自服退烧药物仍反复发热。无鼻塞、流涕。无头痛,无全身酸痛,无全身乏力。咽充血,扁桃体未见肿大。血常规:白细胞 15.56*10^9/L,中性粒细胞12.60*10^9/L。用药3天后复诊,家属诉用药当晚热退,经48小时以上未再发热,未诉明显不适。
例4:周某,女,9月,因“发热3天”就诊。初始反复发热3天,热峰 38.5摄氏度,偶有喷嚏、咳痰,无咳嗽,无鼻塞流涕,纳差,眠可,二便调。咽充血,扁桃体1度肿大,滤泡红肿,未见脓性分泌物,两肺呼吸音清,未闻及干、湿性啰音。血常规:白细胞12.70*10^9/L,淋巴细胞数6.37*10^9/L,单核细胞数1.57*10^9/L。用药3天后回访,家属诉患儿热退,偶有鼻塞、喷嚏,未诉咳嗽、咳痰等明显不适,食欲尚可,眠可,二便调。
例5:刘某,男,3岁,因“发热1天”就诊。初始发热,热峰38.2摄氏度,活动后呕吐1次,无鼻塞流涕,无咳嗽咳痰,自诉咽痛,未诉头痛。胃纳一般,眠可,二便调。咽充血,扁桃体1度肿大,未见脓性分泌物,两肺呼吸音清,未闻及干、湿性啰音。用药4天后复诊,家属诉患儿已退热超过48 小时,未诉咽痛等不适,咽略红,扁桃体未见肿大,未见脓性分泌物。
尽管已经示出和描述了本发明的实施例,本领域的普通技术人员可以理解:在不脱离本发明的原理和宗旨下可以对这些实施例进行多种变化、修改、替换和变型,本发明的范围由权利要求及其等同物限定。
Claims (5)
1.一种治疗小儿风寒感冒的药物,其特征在于,所述药物作为药浴汤剂应用,所述药浴汤剂为每38℃~40℃的3000mL温水中加入200~400mL药物汤剂制备而成;按质量计,所述药物由以下原料药组成:藿香45g,厚朴10g,陈皮30g,白芷30g,紫苏梗10g,茯苓皮35g,生姜20g,姜半夏45g,砂仁20g;所述药物汤剂制备过程为,称量原料药,先行用清水浸泡30分钟;将浸泡后的中药原料药物及其浸泡的药水加入到煎药容器中,加盖共同煎煮,先用武火使煎药容器中药液沸腾,再使用文火熬制15~20分钟;滤出的药液,即为药物汤剂。
2.根据权利要求1所述的一种治疗小儿风寒感冒的药物,其特征在于,所述藿香为广藿香。
3.根据权利要求1所述的一种治疗小儿风寒感冒的药物,其特征在于,所述厚朴为姜厚朴。
4.根据权利要求3所述的一种治疗小儿风寒感冒的药物,其特征在于,所述姜厚朴是通过厚朴丝照姜汁炙法炒干后制得。
5.根据权利要求1~4任一项所述一种治疗小儿风寒感冒的药物的制备方法,其特征在于,包括以下步骤:
(1)根据需求,称量原料药,先行用清水浸泡30分钟;
(2)将浸泡后的中药原料药物及其浸泡的药水加入到煎药容器中,加盖共同煎煮,先用武火使煎药容器中药液沸腾,再使用文火熬制15~20分钟;
(3)滤出药液,所得药液即为治疗小儿风寒感冒的药物,所述治疗小儿风寒感冒的药物为汤剂。
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