CN114711244B - Composite dispersing agent and application thereof in preparation of water dispersible granule - Google Patents
Composite dispersing agent and application thereof in preparation of water dispersible granule Download PDFInfo
- Publication number
- CN114711244B CN114711244B CN202110003177.7A CN202110003177A CN114711244B CN 114711244 B CN114711244 B CN 114711244B CN 202110003177 A CN202110003177 A CN 202110003177A CN 114711244 B CN114711244 B CN 114711244B
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- CN
- China
- Prior art keywords
- water dispersible
- dispersible granule
- dispersing agent
- flazasulfuron
- composite dispersing
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000004562 water dispersible granule Substances 0.000 title claims abstract description 84
- 239000002270 dispersing agent Substances 0.000 title claims abstract description 54
- 239000002131 composite material Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title abstract description 12
- 239000000575 pesticide Substances 0.000 claims abstract description 36
- 239000005514 Flazasulfuron Substances 0.000 claims abstract description 32
- HWATZEJQIXKWQS-UHFFFAOYSA-N Flazasulfuron Chemical compound COC1=CC(OC)=NC(NC(=O)NS(=O)(=O)C=2C(=CC=CN=2)C(F)(F)F)=N1 HWATZEJQIXKWQS-UHFFFAOYSA-N 0.000 claims abstract description 32
- -1 alkyl naphthalene sulfonate formaldehyde Chemical compound 0.000 claims abstract description 32
- 239000004480 active ingredient Substances 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims description 16
- 239000000080 wetting agent Substances 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical group [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 3
- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- 239000005499 Clomazone Substances 0.000 claims description 2
- 229920002261 Corn starch Polymers 0.000 claims description 2
- 239000005906 Imidacloprid Substances 0.000 claims description 2
- 229920000881 Modified starch Polymers 0.000 claims description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 235000012211 aluminium silicate Nutrition 0.000 claims description 2
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 2
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims description 2
- 229940077388 benzenesulfonate Drugs 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- KIEDNEWSYUYDSN-UHFFFAOYSA-N clomazone Chemical compound O=C1C(C)(C)CON1CC1=CC=CC=C1Cl KIEDNEWSYUYDSN-UHFFFAOYSA-N 0.000 claims description 2
- 239000008120 corn starch Substances 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 2
- CXEGAUYXQAKHKJ-NSBHKLITSA-N emamectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](NC)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 CXEGAUYXQAKHKJ-NSBHKLITSA-N 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- YWTYJOPNNQFBPC-UHFFFAOYSA-N imidacloprid Chemical compound [O-][N+](=O)\N=C1/NCCN1CC1=CC=C(Cl)N=C1 YWTYJOPNNQFBPC-UHFFFAOYSA-N 0.000 claims description 2
- 229940056881 imidacloprid Drugs 0.000 claims description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
- 229940070765 laurate Drugs 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 claims description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- 239000005909 Kieselgur Substances 0.000 claims 1
- SUZRRICLUFMAQD-UHFFFAOYSA-N N-Methyltaurine Chemical compound CNCCS(O)(=O)=O SUZRRICLUFMAQD-UHFFFAOYSA-N 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- 238000012360 testing method Methods 0.000 abstract description 30
- 239000000725 suspension Substances 0.000 abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 24
- 230000002265 prevention Effects 0.000 abstract description 8
- 235000001602 Digitaria X umfolozi Nutrition 0.000 abstract description 6
- 235000017898 Digitaria ciliaris Nutrition 0.000 abstract description 6
- 235000005476 Digitaria cruciata Nutrition 0.000 abstract description 6
- 235000006830 Digitaria didactyla Nutrition 0.000 abstract description 6
- 235000005804 Digitaria eriantha ssp. eriantha Nutrition 0.000 abstract description 6
- 235000010823 Digitaria sanguinalis Nutrition 0.000 abstract description 6
- 244000025670 Eleusine indica Species 0.000 abstract description 6
- 235000014716 Eleusine indica Nutrition 0.000 abstract description 6
- 244000150195 Cyperus longus Species 0.000 abstract description 5
- 238000004062 sedimentation Methods 0.000 abstract description 2
- 238000000926 separation method Methods 0.000 abstract description 2
- 238000003860 storage Methods 0.000 abstract description 2
- 235000018109 Cyperus longus Nutrition 0.000 abstract 1
- 244000075634 Cyperus rotundus Species 0.000 abstract 1
- 235000005010 Scirpus paludosus Nutrition 0.000 abstract 1
- 239000002245 particle Substances 0.000 description 17
- 239000003814 drug Substances 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 239000006185 dispersion Substances 0.000 description 9
- 238000012216 screening Methods 0.000 description 9
- 239000000945 filler Substances 0.000 description 8
- 241000196324 Embryophyta Species 0.000 description 7
- 238000001035 drying Methods 0.000 description 7
- 238000004898 kneading Methods 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- 238000005469 granulation Methods 0.000 description 6
- 230000003179 granulation Effects 0.000 description 6
- 229940095686 granule product Drugs 0.000 description 6
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000005800 Kresoxim-methyl Substances 0.000 description 4
- 239000012752 auxiliary agent Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- ZOTBXTZVPHCKPN-HTXNQAPBSA-N kresoxim-methyl Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC=C1C ZOTBXTZVPHCKPN-HTXNQAPBSA-N 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 244000025254 Cannabis sativa Species 0.000 description 3
- 241000234653 Cyperus Species 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 241000404546 Soliva Species 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 244000058871 Echinochloa crus-galli Species 0.000 description 2
- 231100000674 Phytotoxicity Toxicity 0.000 description 2
- JAWMENYCRQKKJY-UHFFFAOYSA-N [3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-ylmethyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]methanone Chemical compound N1N=NC=2CN(CCC=21)CC1=NOC2(C1)CCN(CC2)C(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F JAWMENYCRQKKJY-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000005338 heat storage Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229940104261 taurate Drugs 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 238000004260 weight control Methods 0.000 description 2
- 238000004383 yellowing Methods 0.000 description 2
- OCUSNPIJIZCRSZ-ZTZWCFDHSA-N (2s)-2-amino-3-methylbutanoic acid;(2s)-2-amino-4-methylpentanoic acid;(2s,3s)-2-amino-3-methylpentanoic acid Chemical compound CC(C)[C@H](N)C(O)=O.CC[C@H](C)[C@H](N)C(O)=O.CC(C)C[C@H](N)C(O)=O OCUSNPIJIZCRSZ-ZTZWCFDHSA-N 0.000 description 1
- 241001290610 Abildgaardia Species 0.000 description 1
- 108010000700 Acetolactate synthase Proteins 0.000 description 1
- 244000300297 Amaranthus hybridus Species 0.000 description 1
- 235000004135 Amaranthus viridis Nutrition 0.000 description 1
- 235000011305 Capsella bursa pastoris Nutrition 0.000 description 1
- 240000008867 Capsella bursa-pastoris Species 0.000 description 1
- 244000052363 Cynodon dactylon Species 0.000 description 1
- 241000234646 Cyperaceae Species 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 240000003173 Drymaria cordata Species 0.000 description 1
- 206010024796 Logorrhoea Diseases 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- 235000010086 Setaria viridis var. viridis Nutrition 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- 244000152045 Themeda triandra Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 240000001102 Zoysia matrella Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 244000230342 green foxtail Species 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000002363 herbicidal effect Effects 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a composite dispersing agent and application thereof in preparation of water dispersible granules, in particular to flazasulfuron water dispersible granules. The invention is compounded with active ingredients by adding a composite dispersing agent, wherein the composite dispersing agent specifically comprises alkyl naphthalene sulfonate formaldehyde condensate and sulfosuccinic monoester in a specific ratio of 1:1-2. The pesticide water dispersible granule prepared by the invention has better suspension property, dispersibility and stability. Rapidly disintegrates after being added with water, has finer grain diameter, proper viscosity, good fluidity, difficult water separation and sedimentation and good storage stability, has strong stability at-4 ℃ and 54 ℃, the suspension rate is more than 95 percent, no caking exists, and the viscosity is basically kept unchanged. Moreover, the test result proves that the flazasulfuron water dispersible granule has the prevention and treatment efficacy of 98% on nutgrass galingale rhizome and crabgrass, the prevention and treatment level is obviously improved, and the flazasulfuron water dispersible granule has good industrial application value.
Description
Technical Field
The invention relates to the field of pesticide preparations, in particular to a composite dispersing agent and application thereof in preparation of water dispersible granules, and particularly relates to flazasulfuron water dispersible granules.
Background
Flazasulfuron (Flazasulfuron) is a sulfonylurea herbicide that mainly inhibits the reaction of acetolactate synthase, a precursor for the production of side chain amino acids, leucine, isoleucine and valine. Can effectively prevent and remove most of lawn weeds, is suitable for warm-season lawns (zoysia and bermuda grass), and has high safety to lawn weeds. The product has broad weed control spectrum, and can effectively prevent and remove most grass family, sedge family and broadleaf weeds in 3-4 leaf period, and has especially outstanding control effects on barnyard grass, green bristlegrass, garrulous sedge, green amaranth, bluegrass, shepherd's purse, baocai, chickweed and nest.
The water dispersible granule is also called as a dry suspending agent or granular wettable powder, has the particle size of 200-5000 um, and can be rapidly disintegrated when being placed in water to form a high-suspension dispersion system. The water dispersible granule has the following advantages: (1) no dust exists, and the safety to operators is ensured; (2) pesticides which are stable in physicochemical properties, in particular exhibit instability to water; (3) the fluidity is good, the packaging is easy, and the metering is easy; (4) high content of effective components and good dispersibility in water. At present, the water dispersible granule becomes a hot spot for developing new dosage forms, has extremely rapid development, and becomes one of main pesticide dosage forms in the market in China.
The suspension and dispersion rate of the water dispersible granule directly influence the quality of the drug effect, and the main factors influencing the suspension and dispersion rate are more, but the main factors are: the first is the particle size of the particles and the second is the viscosity. In addition, the composition of the adjuvants in the formulation can also have an effect on the suspension rate.
If the pesticide active ingredient is incompatible with the auxiliary ingredient, the problems of incapability of forming due to overlarge particle viscosity or easiness in crushing due to overlarge viscosity, uneven particle size and the like can be generated, so that the suspension rate is reduced, and the absorption of the pesticide to the leaf surface is affected. This is particularly important for stem and leaf treated pesticides, and is derived from factors such as chemically unstable medium (such as impurities brought in raw pesticide) or addition of various auxiliary agents and additives, or when a dispersing agent is selected to be unsuitable, these all cause crosslinking of an adsorption layer, gel and charge to be neutralized or bridging and lap joint of the dispersing agent around particles, so that a protective layer of stable particles is damaged or changed, and further suspension and dispersion performance of the water dispersible granule is affected.
Different from other preparations, the investigation standard of the water dispersible granule also comprises the disintegration property of the water dispersible granule in water. If the formulation of the preparation is imperfect, the strength of the water dispersible granule particles is too high, the disintegration is not facilitated, the strength is too low, the particles are not strong enough and are easy to crush, and the problem that the particles cannot be completely disintegrated to the original particle size is likely to exist in the disintegration process. To a certain extent, the disintegration performance also affects the suspension property and the dispersibility of the water dispersible granule.
Meanwhile, the production process of the water dispersible granule is also required to be completely selected according to the physicochemical properties of the processed pesticide, so that the optimal processing process route is determined.
The existing pesticide water dispersible granule has the following problems:
1. poor physical and chemical properties, especially poor suspension and dispersion, uneven particle size after disintegrating in water, and no suspension, dispersion and disintegration properties meet the requirements.
2. Has lower prevention and treatment effect.
Therefore, the urgent need exists for providing the pesticide water dispersible granule with excellent physical and chemical properties and high prevention effect. The composite dispersing agent is the research focus in recent years, CN1957698A discloses an kresoxim-methyl water dispersible granule, and the embodiment specifically discloses that an alkyl naphthalene sulfonate formaldehyde condensate and dioctyl sodium sulfosuccinate are adopted as the dispersing agent to prepare the kresoxim-methyl water dispersible granule; surprisingly, the applicant found that when a specific proportion of a complex dispersant comprising an alkyl naphthalene sulfonate formaldehyde condensate and disodium sulfosuccinate ethoxylated alcohol monoester is used for preparing the pesticide water dispersible granule, the dispersant has good compatibility with the pesticide active ingredient, particularly flazasulfuron, and the water dispersible granule with excellent physicochemical properties, particularly suspension property and dispersibility can be prepared.
Disclosure of Invention
The invention aims to provide a pesticide composite dispersing agent, and the second purpose is to apply the composite dispersing agent to the preparation of pesticide water dispersible granules, so that the suspension rate, the dispersibility and the prevention and control efficacy of the pesticide water dispersible granules can be effectively improved, and the purposes are realized by the following technical scheme:
a composite dispersing agent consists of alkyl naphthalene sulfonate formaldehyde condensate and sulfosuccinic monoester in the weight ratio of 1:1-2.
A water dispersible granule comprising: 1-75% of pesticide active ingredient, 1-10% of composite dispersing agent, 1-10% of wetting agent and the balance of carrier, wherein the composite dispersing agent is a composition of alkyl naphthalene sulfonate formaldehyde condensate and sulfosuccinic acid monoester with the weight ratio of 1:1-2.
A flazasulfuron water dispersible granule comprising: 10-50% of flazasulfuron, 1-10% of composite dispersant, 1-10% of wetting agent and the balance of carrier, wherein the percentages are weight percentages; the composite dispersing agent is a composition of alkyl naphthalene sulfonate formaldehyde condensate and sulfosuccinic monoester in a weight ratio of 1:1-2.
Preferably, the water dispersible granule comprises the following components in parts by weight: 25% of flazasulfuron, 10% of composite dispersant, 1-10% of wetting agent and the balance of carrier;
preferably, the composite dispersing agent is a composition of alkyl naphthalene sulfonate formaldehyde condensate and sulfosuccinic monoester in a weight ratio of 1:1;
the alkyl naphthalene sulfonate formaldehyde condensate is NNO, NO or MF; preferably NNO;
the sulfosuccinic monoester is disodium sulfosuccinic ethoxylated alcohol monoester;
the wetting agent is one or more of methyl taurate, sodium dodecyl sulfate, fatty acid ester sulfate, laurate, alkylphenol ethoxylate, benzene sulfonate, naphthalene sulfonate and fatty alcohol polyoxyethylene ether;
the carrier is one or more of talcum powder, white carbon black, calcined kaolin, organic bentonite, light calcium carbonate, diatomite, magnesium aluminum silicate, corn starch, sodium sulfate, methyl cellulose and modified corn starch.
The composite dispersing agent provided by the invention is suitable for preparing pesticide water dispersible granules, and particularly has good compatibility with pesticide flazasulfuron. The composite dispersing agent, the wetting agent and the filler are added to serve as auxiliary agents, the auxiliary agents act synergistically, the defect of slow wetting of particles in water is overcome by combining the wetting agent and the filler, the defect of easy agglomeration of suspended particles is overcome by adding the composite dispersing agent, and the particles have the advantages of quick dispersion in water, good atomization, high suspension rate, uniform particle size and the like, so that the water dispersible granule with quick disintegration speed, good suspension dispersibility and uniform particle size is obtained, the stability is greatly improved, and the pesticide water dispersible granule, especially the prevention and treatment effect of the flazasulfuron water dispersible granule, is also improved by selecting the types of the auxiliary agents.
The pesticide water dispersible granule provided by the invention is matched with an active ingredient by adding the composite dispersing agent, is specifically composed of the alkyl naphthalene sulfonate formaldehyde condensate and the sulfosuccinic monoester in a specific proportion, and is combined with proper auxiliary materials for use, so that the pesticide water dispersible granule prepared by the invention has better suspension property, dispersibility and stability. The pesticide water dispersible granule prepared by the invention is rapidly disintegrated after being put into water, has finer grain diameter, proper viscosity, good fluidity, difficult water separation and sedimentation, good storage stability, strong stability at-4 ℃ and 54 ℃, suspension rate of more than 95 percent, no caking and basically unchanged viscosity. Meanwhile, the test result proves that the flazasulfuron water dispersible granule has the prevention and treatment efficacy of 98% on nutgrass galingale rhizome and crabgrass, the prevention and treatment level is obviously improved, and the flazasulfuron water dispersible granule has good industrial application value.
Detailed Description
Example 1 25% flazasulfuron Water dispersible granule
According to the requirements of the formula, the raw materials, the composite dispersing agent, the filler and the like are mixed and crushed, then water is added for kneading, and the mixture is added into a granulator for granulation, and then the water dispersible granule product is prepared after drying and screening.
Example 2 25% flazasulfuron Water dispersible granule
According to the requirements of the formula, the raw materials, the composite dispersing agent, the filler and the like are mixed and crushed, then water is added for kneading, and the mixture is added into a granulator for granulation, and then the water dispersible granule product is prepared after drying and screening.
Example 3 25% flazasulfuron Water dispersible granule
According to the requirements of the formula, the raw materials, the composite dispersing agent, the filler and the like are mixed and crushed, then water is added for kneading, and the mixture is added into a granulator for granulation, and then the water dispersible granule product is prepared after drying and screening.
Example 4 70% Imidacloprid Water dispersible granule
According to the requirements of the formula, the raw materials, the composite dispersing agent, the filler and the like are mixed and crushed, then water is added for kneading, and the mixture is added into a granulator for granulation, and then the water dispersible granule product is prepared after drying and screening.
Example 5 5% emamectin benzoate Water dispersible granule
According to the requirements of the formula, the raw materials, the composite dispersing agent, the filler and the like are mixed and crushed, then water is added for kneading, and the mixture is added into a granulator for granulation, and then the water dispersible granule product is prepared after drying and screening.
Example 6 75% clomazone Water dispersible granule
According to the requirements of the formula, the raw materials, the composite dispersing agent, the filler and the like are mixed and crushed, then water is added for kneading, and the mixture is added into a granulator for granulation, and then the water dispersible granule product is prepared after drying and screening.
The following test is a composite dispersant screening and testing test.
Test example 1 screening of dispersants
Test variety
Variety of dispersant: alkyl naphthalene sulfonate formaldehyde condensate (NNO), carboxymethyl cellulose (CMC), sodium lignin sulfonate (REAX 910), sulfosuccinate (disodium sulfosuccinate ethoxylated alcohol monoester).
Experimental method
According to different performances and actions of the tested dispersants, 25 compound formulas and 4 single formulas are properly combined and screened by adopting a repeated test method. The pesticide flazasulfuron is selected as an active ingredient.
Weighing the following components in percentage by mass: the flazasulfuron content is 25% (test example); the total amount of the composite dispersant is 10 percent (the different compositions and the amounts are shown in Table 1); methyl taurate 8%; the rest is complemented by diatomite.
The preparation method of the pesticide water dispersible granule comprises the following steps: adding the pesticide active ingredients, the compound dispersing agent and the grinding, mixing and crushing into powder, adding water for kneading, adding into a granulator for granulating, drying and screening to obtain the pesticide.
2 test results the test results are shown in Table 1.
Table 1 influence of different dispersant combinations and ratios on Water dispersible granule Performance
As can be seen from table 1, the composite dispersants obtained by combining the dispersant alkylnaphthalene sulfonate formaldehyde condensate (NNO), carboxymethyl cellulose (CMC), sodium lignin sulfonate (REAX 910), and sulfosuccinic acid monoester (disodium sulfosuccinate ethoxylated alcohol monoester) in different types and using the same combination type in different amounts have significant differences in the indexes such as suspension property, dispersibility, and stability. The suspension property and the dispersibility are key indexes for reflecting the performance of the preparation, and the low-temperature and heat storage stability is another important index for reflecting the good and bad performance of the water dispersible granule.
According to the test data in table 1, it can be seen that the composite dispersant obtained by mixing the alkyl naphthalene sulfonate formaldehyde condensate (NNO) and the sulfosuccinic acid monoester (disodium sulfosuccinate ethoxylated alcohol monoester) according to the mass ratio of 1:1-2 has a remarkable synergistic effect, so that the dispersibility and suspension property of the water dispersible granule can be remarkably improved, and the low-temperature and heat storage stability of the water dispersible granule can be effectively improved; that is, when the alkyl naphthalene sulfonate formaldehyde condensate (NNO) and the sulfosuccinic monoester (disodium sulfosuccinate ethoxylated alcohol monoester) are combined in a mass ratio of 1:1-2, the synergistic effect of the two is very remarkable compared to the other combinations; particularly, when the alkyl naphthalene sulfonate formaldehyde condensate (NNO) and the sulfosuccinic acid monoester (sulfosuccinic acid ethoxylated alcohol monoester disodium) are mixed according to the mass ratio of 1:1, compared with other combinations, the prepared pesticide water dispersible granule is obviously superior to other combinations in terms of dispersibility, suspension property, stability and other performances, can comprehensively and obviously improve various performances of the pesticide water dispersible granule, and is very suitable for serving as a composite dispersing agent of the pesticide water dispersible granule, in particular flazasulfuron water dispersible granule.
Test example 2 physical and chemical properties were measured.
Based on the example 1, corresponding water dispersible granules were prepared with the amounts of the components shown in table 2, wherein the total amount of the composite dispersing agent is 10%, the composition of the composite dispersing agent or the active ingredient is only changed, and the dispersion rate and the suspension rate are tested at normal temperature.
TABLE 2 physical and chemical Property test
The test results of the groups 1-10 and 11-14 are compared, and it can be seen that the alkyl naphthalene sulfonate formaldehyde condensate and the disodium sulfosuccinate ethoxylated alcohol monoester are used as the composite dispersing agent for preparing the pesticide water dispersible granule, and are superior to the alkyl naphthalene sulfonate formaldehyde condensate and the sodium dioctyl sulfosuccinate. Test results of 1-10 groups prove that the composite dispersant alkyl naphthalene sulfonate formaldehyde condensate, the disodium sulfosuccinate ethoxylated alcohol monoester and the pesticide active ingredient, especially flazasulfuron, have remarkable synergistic effect. Moreover, according to the comparative tests 1-2, 11-12 and 9-10 and 13-14, it can be seen that the different composite dispersing agent compositions have a larger influence on the performance of the pesticide flazasulfuron water dispersible granule, and a smaller influence on the performance of the kresoxim-methyl water dispersible granule, so that the application range of the different composite dispersing agents is proved to be different, and the optimal conditions are required to be searched. Meanwhile, referring to CN1957698A, the alkyl naphthalene sulfonate formaldehyde condensate and dioctyl sodium sulfosuccinate are prepared into the water dispersible granule (test group 9) taking kresoxim-methyl as an active ingredient in a ratio of 2:1, and the dispersion performance and the suspension performance of the water dispersible granule are far lower than those of the test groups 1-2.
In conclusion, the conclusion is that the invention takes the alkyl naphthalene sulfonate formaldehyde condensate and the disodium sulfosuccinate ethoxylated alcohol monoester of a specific proportion as the composite dispersing agent, so that the dispersibility and suspension property of the pesticide water dispersible granule, in particular the flazasulfuron water dispersible granule, are greatly improved.
Test example 3 field efficacy test of 25% flazasulfuron Water dispersible granule for controlling Menira lawn weeds
1 test materials and test methods
1.1 test agents: 25% flazasulfuron water dispersible granule (invention), 25% flazasulfuron water dispersible granule is sold in the market.
1.2 test targets: warm season turf grass manila, main weed: nutgrass galingale rhizome and crab grass.
1.3 methods of administration: in the period of 2.5-5 leaves of nutgrass flatsedge or crabgrass, the Chinese medicinal materials are diluted with water according to the dosage of the medicament required by the test, and the water consumption per mu is 30 ml/mu.
1.4 investigation method: the turf grass was investigated for the presence of phytotoxicity 7 days after the drug, and the phytotoxicity symptoms (distortion, albino yellowing, etc.) were recorded in detail, and photographed. Fresh weight control was investigated 21 days after the drug, 5 spots were investigated per treatment, and 1m2 weeds were weighed and recorded per spot.
1.5, calculation of control effect: control (%) = [ (fresh weight of weed in clear water control group-fresh weight of weed in treatment group)/fresh weight of weed in clear water group ] ×100
2 test results: the results of the field efficacy investigation are shown in tables 2 and 3.
Table 3 results questionnaire for field efficacy test of controlled nutgrass galingale rhizome
| Test agent | Dosage of preparation (g/mu) | Content of active ingredient (g/mu) | Control effect (%) |
| Example 1 | 8 | 2 | 90.37b |
| Example 2 | 12 | 3 | 95.25ab |
| Example 3 | 16 | 4 | 98.42a |
| Commercial medicament | 8 | 2 | 81.21d |
| Commercial medicament | 12 | 3 | 85.49c |
| Commercial medicament | 16 | 4 | 90.26b |
| Clear water control | / | / | / |
TABLE 4 results questionnaire for field efficacy test of control of crabs
| Test agent | Dosage of preparation (g/mu) | Content of active ingredient (g/mu) | Control effect (%) |
| Example 1 | 8 | 2 | 85.14c |
| Example 2 | 12 | 3 | 91.20b |
| Example 3 | 16 | 4 | 97.83a |
| Commercial medicament | 8 | 2 | 80.01d |
| Commercial medicament | 12 | 3 | 83.17cd |
| Commercial medicament | 16 | 4 | 88.24bc |
| Clear water control | / | / | / |
By examining the test results and combining tables 3 and 4, the following conclusions can be drawn: each treatment after 7 days of the drug is safe to the manila lawn, has no drug injury, and has the symptoms of slight yellowing after the nutgrass galingale and barnyard grass start to be poisoned. Fresh weight control effect investigation 21 days after medicine shows that: with the increase of the dosage of the 25% flazasulfuron water dispersible granule, the control effect on the weed nutgrass flatsedge and crabgrass is improved, and the control effect of the 25% flazasulfuron water dispersible granule on the weed nutgrass flatsedge and crabgrass in turf grass is obviously better than that of the 25% flazasulfuron water dispersible granule sold in the market with the same dosage.
While the present invention has been described with respect to one embodiment of the invention and its use in preparing water dispersible granules, those skilled in the art may, by reference to the present invention, suitably modify the links of the raw materials, process conditions, etc. to achieve other corresponding objects, and all similar alternatives and modifications will be apparent to those skilled in the art without departing from the scope of the invention.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather to enable any modification, equivalent replacement, improvement or the like to be made within the spirit and principles of the invention.
Claims (7)
1. A water dispersible granule, comprising: 1-75% of pesticide active ingredient, 1-10% of composite dispersing agent, 1-10% of wetting agent and the balance of carrier, wherein the percentages are weight percentages;
the composite dispersing agent is a composition of alkyl naphthalene sulfonate formaldehyde condensate and sulfosuccinic monoester in a weight ratio of 1:1-2;
the pesticide active ingredient is one of imidacloprid, emamectin benzoate, flazasulfuron and clomazone;
the alkyl naphthalene sulfonate formaldehyde condensate is NNO, NO or MF.
2. The water dispersible granule according to claim 1, wherein the water dispersible granule comprises the following components and the amounts thereof: 10-50% of flazasulfuron, 1-10% of composite dispersing agent, 1-10% of wetting agent and the balance of carrier.
3. The water dispersible granule according to claim 2, wherein the water dispersible granule comprises the following components and the amounts thereof: 25% of flazasulfuron, 10% of composite dispersing agent, 1-10% of wetting agent and the balance of carrier.
4. The water dispersible granule according to claim 1, wherein the composite dispersant is a combination of an alkyl naphthalene sulfonate formaldehyde condensate and a sulfosuccinic monoester in a weight ratio of 1:1.
5. The water dispersible granule according to claim 1, wherein the sulfosuccinic monoester is disodium sulfosuccinic ethoxylated alcohol monoester.
6. The water dispersible granule according to claim 1, wherein the wetting agent is one or more of methyltaurine, sodium dodecyl sulfate, fatty acid ester sulfate, laurate, alkylphenol ethoxylate, benzenesulfonate, naphthalenesulfonate, fatty alcohol polyoxyethylene ether.
7. The water dispersible granule according to claim 1, wherein the carrier is one or more of talc, white carbon, calcined kaolin, organobentonite, light calcium carbonate, diatomaceous earth, magnesium aluminum silicate, corn starch, sodium sulfate, methylcellulose and modified corn starch.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1269135A (en) * | 1999-03-03 | 2000-10-11 | 日本拜耳农药株式会社 | Farm chemicals preparation for application on water |
| CN1957698A (en) * | 2006-11-24 | 2007-05-09 | 华南理工大学 | Water dispersion granules agent of Kresoxim and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2563261C (en) * | 2004-04-14 | 2013-04-09 | Fmc Corporation | Dispersible pesticidal compositions |
| CA3066512A1 (en) * | 2017-07-06 | 2019-01-10 | Rhodia Operations | Pesticide compositions |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1269135A (en) * | 1999-03-03 | 2000-10-11 | 日本拜耳农药株式会社 | Farm chemicals preparation for application on water |
| CN1957698A (en) * | 2006-11-24 | 2007-05-09 | 华南理工大学 | Water dispersion granules agent of Kresoxim and preparation method |
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