CN114699563A - Load type polyether polyurethane film, preparation method and application thereof - Google Patents
Load type polyether polyurethane film, preparation method and application thereof Download PDFInfo
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- CN114699563A CN114699563A CN202210163402.8A CN202210163402A CN114699563A CN 114699563 A CN114699563 A CN 114699563A CN 202210163402 A CN202210163402 A CN 202210163402A CN 114699563 A CN114699563 A CN 114699563A
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- polyether polyurethane
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- 239000004721 Polyphenylene oxide Substances 0.000 title claims abstract description 64
- 229920000570 polyether Polymers 0.000 title claims abstract description 64
- 229920006264 polyurethane film Polymers 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000002904 solvent Substances 0.000 claims abstract description 9
- 229920001971 elastomer Polymers 0.000 claims abstract description 7
- 239000000806 elastomer Substances 0.000 claims abstract description 7
- 229960002117 triamcinolone acetonide Drugs 0.000 claims description 29
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 claims description 29
- 239000000463 material Substances 0.000 claims description 28
- 229920002635 polyurethane Polymers 0.000 claims description 18
- 239000004814 polyurethane Substances 0.000 claims description 18
- 238000011068 loading method Methods 0.000 claims description 17
- 239000000243 solution Substances 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000011521 glass Substances 0.000 claims description 9
- 239000011259 mixed solution Substances 0.000 claims description 6
- 238000001291 vacuum drying Methods 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 229930192392 Mitomycin Natural products 0.000 claims description 4
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 4
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 4
- 229960005277 gemcitabine Drugs 0.000 claims description 4
- 229960004857 mitomycin Drugs 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000013461 design Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000003517 fume Substances 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000002604 ultrasonography Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 abstract description 9
- 238000011282 treatment Methods 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 239000012567 medical material Substances 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 8
- 229920005862 polyol Polymers 0.000 description 6
- 150000003077 polyols Chemical class 0.000 description 6
- 238000002441 X-ray diffraction Methods 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 238000009864 tensile test Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000003746 surface roughness Effects 0.000 description 4
- 238000012876 topography Methods 0.000 description 3
- RYECOJGRJDOGPP-UHFFFAOYSA-N Ethylurea Chemical compound CCNC(N)=O RYECOJGRJDOGPP-UHFFFAOYSA-N 0.000 description 2
- 238000004566 IR spectroscopy Methods 0.000 description 2
- 241001467552 Mycobacterium bovis BCG Species 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000000968 medical method and process Methods 0.000 description 2
- 238000004439 roughness measurement Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- 238000009210 therapy by ultrasound Methods 0.000 description 2
- 150000003673 urethanes Chemical class 0.000 description 2
- 230000004543 DNA replication Effects 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 208000002399 aphthous stomatitis Diseases 0.000 description 1
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 230000002485 urinary effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/43—Hormones, e.g. dexamethasone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
Abstract
The invention is suitable for the invention to belong to the technical field of medical material, especially relate to a supported polyether urethane film, preparation method and its application, the said supported polyether urethane film includes dissolving polyether urethane (PEUR) in tetrahydrofuran solvent, add the carrier and mix after the supersound, pour in the mould in order to evaporate solvent solute from constitutive elastomer. The supported polyether polyurethane film provided by the invention is prepared by ultrasonically fusing a medicine and a film base liquid in the manufacturing process, so that the film is molded into a tubular shape after being loaded with the film surface, and the loaded carrier has hydrophilicity, so that the film is used for slowly releasing the hydrophilic medicine in a liquid solvent in the medical treatment process, and replaces the prior art that a catheter is taken down and re-inserted after being loaded with the medicine, the operation difficulty and the labor amount of medical staff are reduced, and the pain of a patient can be relieved.
Description
Technical Field
The invention belongs to the technical field of medical materials, and particularly relates to a supported polyether polyurethane film, a preparation method and application thereof.
Background
Polyether urethanes are defined primarily with respect to the polyols in the polyurethane material, i.e., the polyols from which the polyurethanes are made are composed exclusively of polyether polyols or are present in the vast majority of systems. In the molecular structure of polyether polyol, ether bond cohesive energy is low and the polyether polyol is easy to rotate, so that the polyurethane material prepared by the polyether polyol has the advantages of good low-temperature flexibility, excellent hydrolysis resistance, low viscosity of a raw material system, easiness in mutual dissolution of isocyanate, an auxiliary agent and the like, and excellent processing performance.
The medical catheter classification angle can be roughly divided into the following according to the use function: the medical catheter is used for treating and preventing the pain of patients, and is characterized in that the medical catheter comprises an infusion catheter, a hemodialysis catheter, an angiography catheter, a catheter for intravascular interventional therapy, a digestive tract catheter, a respiratory tract catheter, a urinary system catheter, a nerve system catheter, a drainage tube for operation and the like.
Disclosure of Invention
In order to solve the technical problems, the invention provides a supported polyether urethane film, which comprises an elastomer formed by dissolving polyether urethane (PEUR) in a tetrahydrofuran solvent, adding a load carrier, mixing by ultrasound, and pouring in a mold to evaporate solvent solute and form a composition.
Further, the carrier is one or more of triamcinolone acetonide, mitomycin, gemcitabine, pirzidine and bacillus calmette-guerin.
The invention also provides a preparation method of the load type polyether polyurethane film, which comprises the following steps:
s1, dissolving polyether urethane (PEUR) in a tetrahydrofuran solvent, and completely dissolving a solute by magnetically stirring for 4 days at room temperature to obtain a uniform transparent solution with the concentration of 1g/20 ml;
s2, adding a loading agent with required dosage into the transparent solution obtained in the step S1, and uniformly dispersing the loading agent in the solution through ultrasonic treatment for 30 minutes to obtain a loading agent-polyether polyurethane mixed solution;
s3, pouring the carrier agent-polyether type polyurethane mixed solution into a glass culture dish, horizontally placing the glass culture dish in a fume hood, and volatilizing at room temperature for 1 week to preliminarily obtain a load type polyether type polyurethane-based membrane material;
and S4, drying the materials in a vacuum drying oven for 2 days to completely volatilize the tetrahydrofuran solvent in the materials to obtain the required load type polyether polyurethane film.
Furthermore, in step S2, in order to search for a proper drug dosage, a gradient design is adopted, the transparent solution with the concentration of 1g/20ml obtained in step S1 is divided into four groups of PEUR-0, PEUR-1, PEUR-2 and PEUR-4, and 0, 25, 50 and 100mg of loading agent is respectively added into the transparent solutions of the groups of PEUR-0, PEUR-1, PEUR-2 and PEUR-4.
Further, in step S3, the diameter of the glass culture dish is 8-10mm, and the bottom surface is smooth and flat.
Further, the vacuum drying oven at the step S4 has an internal temperature of 40-50 ℃.
The invention also provides a load type polyether polyurethane film and application thereof in preparation of catheters in the field of medical supplies.
In summary, compared with the prior art, the invention provides a supported polyether urethane film, a preparation method and an application thereof, wherein the supported polyether urethane film comprises an elastomer which is formed by dissolving polyether urethane (PEUR) in a tetrahydrofuran solvent, adding a loading agent, mixing by ultrasonic, and pouring in a mold to evaporate a solvent solute. In the manufacturing process, the medicine and the film base liquid are ultrasonically fused, so that the film base liquid is loaded on the surface of the film and then molded into a tubular shape, and the loading agent has hydrophilicity and is used for slowly releasing the hydrophilic medicine in a liquid solvent in the medical process, so that the problem that in the prior art, a catheter is taken down, loaded with the medicine and then reinserted into the catheter is solved, the operation difficulty and the labor amount of medical workers are reduced, and the pain of a patient can be relieved.
Drawings
FIG. 1 is a flow chart of a preparation method of a supported polyether polyurethane film provided by the invention;
FIG. 2 is a surface topography map of a supported polyether polyurethane film provided in example 3 of the present invention after scanning with a scanning electron microscope;
FIG. 3 is an X-ray diffraction (XRD) analysis spectrum of the supported polyether urethane film provided in example 3 of the present invention;
FIG. 4 is a spectrum of infrared spectroscopy (FTIR) analysis of a supported polyether urethane film provided in example 3 of the present invention;
FIG. 5 is a three-dimensional morphology of four groups of TA/PEUR observed by using a laser confocal 3D microscope on a supported polyether polyurethane film provided by the embodiment 3 of the invention;
FIG. 6 is a graph showing the effect of observing the surface wettability of the supported polyether polyurethane film according to example 3 of the present invention;
FIG. 7 is a graph showing the observation and analysis of the surface wettability by water contact angle of the supported polyether polyurethane film provided in example 3 of the present invention;
FIG. 8 is a stress-strain test graph obtained by performing a tensile test on four groups of supported polyether polyurethane films according to embodiment 3 of the present invention;
FIG. 9 is a Young's modulus test chart obtained by performing a tensile test on four groups of supported polyether polyurethane films provided in example 3 of the present invention;
FIG. 10 is a tensile strength test chart obtained by a tensile test on four groups of supported polyether polyurethane films according to example 3 of the present invention;
fig. 11 is a strain limit test chart obtained by performing a tensile test on four groups of supported polyether urethane films provided in example 3 of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The invention provides a load type polyether urethane film, a preparation method and application thereof, wherein the load type polyether urethane film comprises an elastomer which is formed by dissolving polyether urethane (PEUR) in a tetrahydrofuran solvent, adding a load carrier, mixing by ultrasonic waves, and pouring in a mould to evaporate a solvent solute. In the manufacturing process, the medicine and the film base liquid are ultrasonically fused, so that the film base liquid is loaded on the film base liquid and then is molded into a tubular shape, and the loading agent has hydrophilicity and is used for slowly releasing the hydrophilic medicine in the liquid solvent in the medical process, so that the catheter is replaced by the catheter which is taken down and loaded and then is reinserted in the prior art, the operation difficulty and the labor amount of medical staff are reduced, and the pain of a patient can be relieved.
Example 1
The invention provides a load type polyether urethane film, which comprises an elastomer formed by dissolving polyether urethane (PEUR) in a tetrahydrofuran solvent, adding a load carrier, mixing by ultrasonic, and pouring in a mold to evaporate solvent solute; in this embodiment, the polyether urethanes are Pellethane thermal polyurethane polyurethanes, Lubrizol Pellethane Lu Borun 2363-80A; tetrahydrofuran purchase: CAS number 109-99-9, T103266 tetrahydrofuran, ACS ≥ 99.0% (GC), polypeptides 250 ppm BHT as inhibitor, available from Aladdin Biotechnology Ltd, China, Shanghai.
Further, the negative carrier is one or more of triamcinolone acetonide, mitomycin, gemcitabine, pirzidine and bacillus calmette guerin.
In this embodiment, the carrier is triamcinolone acetonide.
Example 2
The present invention provides a method for preparing a supported polyether urethane film, wherein the supported polyether urethane film comprises an elastomer as described in example 1, the method comprising:
s1, dissolving polyether urethane (PEUR) in a tetrahydrofuran solvent, and completely dissolving a solute by magnetically stirring for 4 days at room temperature to obtain a uniform transparent solution with a concentration of 1g/20ml, because the concentration of 1g/20ml is close to the maximum solubility;
s2, adding a required dosage of a loading agent (in the embodiment, the loading agent is triamcinolone acetonide TA) into the transparent solution obtained in the step S1, and performing ultrasonic treatment for 30 minutes to uniformly disperse the loading agent in the solution to obtain a loading agent-polyether polyurethane mixed solution;
s3, pouring the carrier agent-polyether type polyurethane mixed solution into a glass culture dish, horizontally placing the glass culture dish in a fume hood, and volatilizing at room temperature for 1 week to preliminarily obtain a load type polyether type polyurethane-based membrane material; furthermore, the diameter of the glass culture dish is 8-10mm, and the bottom surface is smooth and flat;
s4, placing the load type polyether polyurethane base film obtained primarily in the step S3 in a vacuum drying oven for drying for 2 days to completely volatilize a tetrahydrofuran solvent in the material to obtain a required load type polyether polyurethane film; further, the temperature in the vacuum drying oven is 40-50 ℃.
Further, in order to search for a proper dosage of the drug in this example, a gradient design was adopted, and the transparent solution with a concentration of 1g/20ml obtained in step S1 was divided into four groups of PEUR-0, PEUR-1, PEUR-2, and PEUR-4; 0, 25, 50 and 100mg of triamcinolone acetonide is added into the four groups of transparent solutions respectively, the load condition of the triamcinolone acetonide is analyzed and observed, and the performance of the four groups of load type polyether polyurethane-based film materials is measured.
| Packet sequence number | Weight percent TA/PEUR (wt%) | TA load (mg/cm)2） |
| PEUR-0 | 0 | 0 |
| PEUR-1 | 2.5 | 0.393 |
| PEUR-2 | 5.0 | 0.786 |
| PEUR-3 | 10.0 | 1.573 |
The method for specifically analyzing and observing the load condition comprises the following steps:
1. by Scanning Electron Microscope (SEM);
the material surface was sprayed with gold using a high resolution coater (208 HR, creation, UK) prior to observation, taking into account the non-conductivity of the material during scanning by electron microscopy (SEM). The surface topography of the film was observed by SEM (SUPRA 35, LEO, Germany) at a working distance of 10.7mm, applying a working voltage of 20kv, at 1000 times and 10000 times, respectively, and is shown in fig. 2, respectively.
2. Compositional analysis X-ray diffraction (XRD), infrared spectroscopy (FTIR);
the composition, crystallinity of the material was first analyzed by X-ray diffraction (XRD, D8 Advance, BRUKER, Germany) using Cu k α radiation at a rate of 0.5s/step from 5 ° to 60 ° 2 θ angle. The material 4000 + 400 cm was further analysed by infrared (FTIR, Cary 630, Agilent, Germany)−1Chemical groups in the absorption spectral range. The X-ray diffraction analysis pattern is shown in fig. 3, and the characteristic peak of polyurethane PEUR corresponds to a broad peak with 2 θ of 19.7 °, indicating that PEUR is in an amorphous state. Wherein, the sharp peaks with 2 theta of 9.8 degrees, 14.4 degrees, 17.5 degrees and 24.7 degrees respectively correspond to the characteristic peaks of triamcinolone acetonide TA, which shows that the TA has higher crystallinity and larger crystal grains. The TA characteristic peak signals in the PERU-0, 1, 2 and 4 are continuously enhanced, which shows that the TA component in the film is continuously increased and is consistent with the forecast.
The pattern analyzed by FTIR is shown in FIG. 4, in which 3398, 1663, 1613, 1055cm-1Is the typical stretching vibration peak of TA. Wherein 3398cm-1Stretching vibration corresponding to hydrogen bonding hydroxyl radical, 1663 cm-1Stretching vibration corresponding to carbonyl group on ester bond of fatty acid, 1613 cm-1Stretching vibration corresponding to C = C unsaturated bond, 1055cm-1Corresponding to the stretching vibration of C-F. The peak intensity corresponds to the variation of TA content.
3. Surface roughness;
the surface roughness of the material was analyzed by measuring the three-dimensional morphology of the material surface using a laser confocal 3D microscope (Olympus OLS4000, Olympus, Japan). The line roughness measurement Ra and the surface roughness measurement Sa of the material were obtained at 50 magnification, each sample being measured three times separately.
The results of observing the three-dimensional topography of four groups of TA/PEUR are shown in FIG. 5, wherein Ra corresponds to the line roughness and the height fluctuation of the macroscopic level of the reaction material. Sa corresponds to the surface roughness, the local mean waviness of the reaction material. From the results, it can be seen that the loading of TA can reduce the roughness of the material to a certain extent, and the smooth surface is not easy for cell adhesion growth, and at the same time, the practical comfort can be improved. The overall roughness of the material loaded with TA is similar.
4. Static water contact angle;
making the material into 10 x 10mm2The square sheet of (a) is adhered to the slide and remains flat. mu.L of ultrapure water was dropped on the surface of the material, and the static water contact angles of the material were measured at 10s, 30s, and 60s with a contact angle measuring instrument (OCA 15PRO, DATAPHYSICS, Germany), respectively. Repeat 3 times.
The water contact angle and surface wettability observation and analysis graphs are shown in fig. 6 and 7, and the water contact angle of the film is reduced along with the loading of TA, the hydrophilicity is improved, the surface wettability is improved, and the comfort of the material is also improved.
5. Tensile test was carried out on four groups of supported polyether urethane films
The material was made into a 5 x 25mm rectangular pattern with a practical working gauge length of 10mm, held at both ends in an electronic universal tester (Instron 5848, Instron, America) and run at a speed of 15 mm/min. Each set of 5 replicate experimental sets to obtain tensile strength, young's modulus and ultimate strain.
The results of the stress-strain test curve are shown in FIG. 8; the Young modulus test results are shown in FIG. 9; the tensile strength test results are shown in fig. 10; the ultimate strain test results are shown in fig. 11;
overall, the loading of TA improves the mechanical properties of the material, and the tensile strength, elastic modulus, and elongation at break are all improved. However, the TA content increased to 0.786 mg/cm2In time, the mechanical properties of the PEUR-2 are highest. The tensile strength is increased from 9.89MPa to 14.24MPa, the elastic modulus is 3 times that of the PEUR-0 from 0.15MPa, and the ultimate strain (namely the elongation at break) is increased from 611.87 percent693.61%。
Example 3
The supported polyether urethane film as described in examples 1 and 2 is applied to the preparation of medical catheter products, and the drug is loaded in the catheter, because the above-mentioned carrier loaded on the TA/PEUR, such as the drug Triamcinolone Acetonide (TA), is slowly released during the treatment process. Specifically, when the carrier is Triamcinolone Acetonide (TA), the anti-inflammatory composition can be used for anti-inflammatory application in treatment of skin diseases, aphthous ulcers and the like; when the loading machine is one or more of mitomycin, gemcitabine, pirzidine and BCG, the loading machine can be used for DNA depolymerization, antagonistic DNA replication and the like in the process of tumor treatment so as to replace the prior art that the catheter is taken down and loaded and then reinserted, thereby reducing the operation difficulty and the labor amount of medical care personnel and relieving the pain of patients.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (7)
1. A supported polyether polyurethane film is characterized in that polyether Polyurethane (PEUR) is dissolved in a tetrahydrofuran solvent, then a load carrier is added, ultrasonic mixing is carried out, and the mixture is poured into a mold to evaporate solvent solute to form a self-assembled elastomer.
2. The supported polyether polyurethane film as claimed in claim, wherein the carrier is one or more of triamcinolone acetonide, mitomycin, gemcitabine, pirzidine, and bcg.
3. A preparation method of a supported polyether polyurethane film is characterized by comprising the following steps:
s1, dissolving polyether urethane (PEUR) in a tetrahydrofuran solvent, and completely dissolving a solute by magnetically stirring for 4 days at room temperature to obtain a uniform transparent solution with the concentration of 1g/20 ml;
s2, adding a required dosage of a negative carrier into the transparent solution obtained in the step S1, and uniformly dispersing the negative carrier into the solution through ultrasound for 30 minutes to obtain a negative carrier-polyether polyurethane mixed solution;
s3, pouring the carrier-polyether polyurethane mixed solution into a glass culture dish, horizontally placing the glass culture dish in a fume hood, and volatilizing at room temperature for 1 week to preliminarily obtain a load-type polyether polyurethane-based membrane material;
and S4, drying the materials in a vacuum drying oven for 2 days to completely volatilize the tetrahydrofuran solvent in the materials to obtain the required load type polyether polyurethane film.
4. The method of claim 3, wherein the step S2 is a step of dividing the transparent solution with a concentration of 1g/20ml obtained in step S1 into four groups of PEUR-0, PEUR-1, PEUR-2 and PEUR-4 by a gradient design to search for a proper dosage of the drug, and adding 0, 25, 50 and 100mg of the loading agent to the groups of the transparent solutions PEUR-0, PEUR-1, PEUR-2 and PEUR-4.
5. The method for preparing a supported polyether polyurethane film according to claim 3, wherein in step S3, the glass petri dish has a diameter of 8-10mm and a smooth and flat bottom surface.
6. The method of preparing a supported polyether polyurethane film according to claim 3, wherein the vacuum drying oven temperature in step S4 is 40-50 ℃.
7. The supported polyether polyurethane film according to any one of claims 1 to 6, wherein the film is used for preparing a catheter in the field of medical supplies.
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