CN114624435A - Magnetic separation subassembly and immunodetection analysis appearance - Google Patents

Abstract

The application provides a magnetism separable set and immunity detection analysis appearance, this immunity detection analysis appearance is including advancing kind tongs and magnetism separable set, and magnetism separable set includes and is the polylith magnet that the ring form was hugged closely and is arranged on the coplanar, advances kind tongs and is used for grasping this pipe of sample and arranges the department of hugging closely of two adjacent magnets in and carry out the magnetism separation operation. According to the magnetic separation assembly, the plurality of magnets which are arranged in a ring-shaped manner in a clinging manner are formed on the same plane, a magnetic field is formed at the end face where adjacent magnets are arranged in a clinging manner, when magnetic beads in the sample tube are close to the end face, magnetic attraction can be applied to the magnetic beads through the magnetic field, and the adsorption time and the cleaning time in the magnetic separation process can be shortened; meanwhile, the magnets are closely arranged in a ring shape, so that the arrangement among the magnets is more compact, the magnetic separation operation can be simultaneously carried out on a plurality of sample tubes, the magnetic separation efficiency can be improved, and the magnetic separation device is simple in structure, compact in size and convenient to use and maintain.

Description

Magnetic separation subassembly and immunodetection analysis appearance

Technical Field

The application relates to the technical field of medical equipment, in particular to a magnetic separation assembly and an immunoassay analyzer.

Background

An immunoassay analyzer is an apparatus capable of immunologically and quantitatively analyzing a body fluid sample of a patient, and can be used for detecting diseases such as anemia, cardiovascular diseases, congenital diseases, sex hormones, infectious diseases, metabolic functions, tumor markers, monitoring of therapeutic drugs, thyroid gland and the like. The immunoassay analyzer has good sensitivity and specificity and wide detection range due to the adoption of the micro-multiplication technology, and is widely applied clinically. The immunoassay analyzer adds a reaction reagent containing micron-sized or nano-sized magnetic beads into a sample to be detected, wherein antigens or antibodies are magnetically adsorbed on the surfaces of the magnetic beads, the magnetic beads can be selectively combined with target substances in the sample to be detected through antigen or antibody reaction, and when the sample to be detected passes through a magnetic field device, the target substances combined with the magnetic beads are retained by the magnetic field and are separated from other substances in other samples to be detected. After the reaction between the target substance in the sample to be detected and the magnetic beads is completed, the magnetic beads need to be cleaned to remove the unreacted body fluid sample and the reagent, and the reacted compound using the magnetic beads as the solid phase carrier is left for the detection of the immune substance.

When an immunoassay analyzer using magnetic beads as reaction carriers is cleaned, the conventional immunoassay analyzer usually has permanent magnets alternately arranged at intervals at two ends of a cleaning mechanism, and the magnetic beads move towards the direction of the permanent magnets through a magnetic field formed by the permanent magnets and are attached to the cup wall on one side of a sample tube close to the permanent magnets. However, in this scheme, the magnetic field intensity of the permanent magnets alternately arranged at intervals is small, the adsorption force to the magnetic beads is weak, the time spent in the adsorption process is long, and it is difficult to sufficiently clean the parts except the surface layer of the magnetic bead layer adsorbed on the side wall in the cleaning process, so that the cleaning is insufficient; and the number of sample tubes which can be simultaneously subjected to magnetic separation by the permanent magnets alternately arranged at intervals is small, and the detection efficiency is low.

Disclosure of Invention

The application provides a magnetic separation subassembly and sample analysis appearance to solve among the prior art magnetic bead and wash the technical problem insufficient, that detection efficiency is low.

In order to solve the technical problem, the application adopts a technical scheme that: providing a magnetic separation assembly, the magnetic separation assembly comprising:

and the magnets are arranged on the same plane in a ring shape and are closely attached.

According to an embodiment of the present invention, the plurality of magnets are flat and have through holes for fixing in a thickness direction.

According to a specific embodiment of the present invention, each of the magnets has a fan-shaped ring structure, each of the magnets includes an upper fan-shaped ring surface and a lower fan-shaped ring surface which are opposite to each other, an inner arc surface and an outer arc surface which are arranged inside and outside, and two end surfaces which are arranged in a non-parallel and symmetrical manner, the two end surfaces of each of the magnets are tightly attached to the end surfaces of the adjacent magnets, the magnetization direction of the magnets is radial magnetization, and the inner arc surface and the outer arc surface are two polar end surfaces of the magnets.

According to a specific embodiment of the invention, the magnetic separation assembly is arranged on the outer periphery and/or the inner periphery of the sample tube, and when the sample tube is at a preset position relative to the magnetic separation assembly, the magnetic separation assembly can perform magnetic separation operation on the sample tube; the preset position is that the included angle between the connecting line of the center of the sample tube and the center of the magnetic separation assembly and the corresponding two magnet end faces which are tightly attached to each other is less than or equal to one fourth of the central angle of the magnet or 10 degrees.

According to an embodiment of the present invention, the plurality of magnets are enclosed into an inner ring set and an outer ring set which are arranged at intervals, and the inner ring set and the outer ring set are arranged in concentric circles.

According to an embodiment of the present invention, the angle of the central angle of at least part of the magnets of the inner ring set is the same as the angle of the central angle of at least part of the iron of the outer ring set.

According to an embodiment of the present invention, end surfaces of at least some of the magnets of the inner ring set are aligned with or offset from end surfaces of corresponding magnets of the outer ring set.

According to an embodiment of the present invention, when the end surfaces of at least some of the magnets of the inner ring set and the end surfaces of the corresponding magnets of the outer ring set are disposed in a staggered manner, an included angle formed by the end surfaces of at least some of the magnets of the inner ring set and the end surfaces of the corresponding magnets of the outer ring set is smaller than one fourth of an angle of a central angle of the magnets.

According to an embodiment of the present invention, when the end surfaces of at least some of the magnets of the inner ring set and the end surfaces of the corresponding magnets of the outer ring set are disposed in a staggered manner, an included angle formed by the end surfaces of at least some of the magnets of the inner ring set and the end surfaces of the corresponding magnets of the outer ring set is less than or equal to 10 degrees.

According to a specific embodiment of the present invention, the inner arc surface of the outer ring set is an S pole, and the outer arc surface of the inner ring set is an N pole; or

The inner arc surface of the outer ring group is an S pole, and the outer arc surface of the inner ring group is an S pole.

In accordance with one embodiment of the present invention,

in order to solve the technical problem, the application adopts a technical scheme that: the utility model provides an immunoassay analyzer, immunoassay analyzer includes advance kind tongs and as aforementioned any one the magnetism separation subassembly, advance kind tongs and be used for grasping the sample this pipe and place in the hugging closely department of two adjacent magnet and carry out the magnetism separation operation.

The beneficial effect of this application is: different from the situation of the prior art, the magnetic separation assembly provided by the application has the advantages that the plurality of magnets which are arranged in a ring-shaped manner in a clinging manner are formed on the same plane, a magnetic field is formed at the end face where adjacent magnets are arranged in a clinging manner, magnetic attraction can be applied to the magnetic beads through the magnetic field when the magnetic beads in the sample tube are close to the end face, and the adsorption time and the cleaning time in the magnetic separation process can be shortened; meanwhile, the magnets are closely arranged in a ring shape, so that the arrangement among the magnets is more compact, the magnetic separation operation can be simultaneously carried out on a plurality of sample tubes, the magnetic separation efficiency can be improved, and the magnetic separation device is simple in structure, compact in size and convenient to use and maintain.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:

FIG. 1 is a schematic view of an assembly structure of a sample tube and a test tube mounting seat of an immunoassay analyzer provided in an embodiment of the present application;

FIG. 2 is a schematic diagram of an assembly structure of a magnetic separation assembly, a test tube mounting seat and a sample tube of the immunoassay analyzer provided in the embodiment of the present application;

FIG. 3 is an exploded view of a magnetic separation module according to an embodiment of the present application;

FIG. 4 is a schematic diagram of a magnetic separation assembly and a sample tube according to an embodiment of the present application;

FIG. 5 is a schematic diagram of a magnetic separation assembly and a sample tube according to an embodiment of the present application;

FIG. 6 is a schematic diagram of a magnetic separation assembly and a sample tube according to an embodiment of the present application;

FIG. 7 is a schematic diagram of a magnetic separation assembly and a sample tube according to an embodiment of the present application;

FIG. 8 is a schematic diagram of a magnetic separation assembly and a sample tube according to an embodiment of the present application;

FIG. 9 is a schematic diagram of a magnetic separation assembly and a sample tube according to an embodiment of the present application;

FIG. 10 is a schematic diagram of a magnetic separation assembly and a sample tube according to an embodiment of the present application;

FIG. 11 is a schematic diagram of a magnetic separation device and a sample tube according to an embodiment of the present application;

FIG. 12 is a schematic diagram illustrating a magnetic separation module and a sample tube according to another embodiment of the present application;

fig. 13 is a schematic structural diagram illustrating a position of a magnetic separation assembly and a sample tube according to another embodiment of the present application.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

It should be noted that if directional indications (such as up, down, left, right, front, and back … …) are referred to in the embodiments of the present application, the directional indications are only used to explain the relative positional relationship between the components, the movement situation, and the like in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are changed accordingly.

In addition, if there is a description of "first", "second", etc. in the embodiments of the present application, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present application.

Referring to fig. 1-3, an immunoassay analyzer according to an embodiment of the present application includes a magnetic separation assembly and a sample introduction gripper for gripping a sample tube to place the sample tube in close contact with a magnet of the magnetic separation assembly for magnetic separation. Wherein, the magnetic separation operation is through will waiting to examine the sample pipe and arrange the magnet in the department that closely pastes, and the adsorption through magnet is done the effect and will be waited to examine in the sample pipe magnetic bead adsorb on the test tube lateral wall to get rid of the cleaning process of magnetic bead surface adhesion impurity through the adsorption of magnet.

Further, magnetic separation subassembly 30 includes polylith magnet 31, and polylith magnet 31 is the clinging arrangement of ring form on the coplanar, and locating hole 51 sets up the clinging department at two adjacent magnet 31, and locating hole 51 is used for holding sample pipe 40 with put sample pipe 40 and carry out the magnetic separation operation with the clinging department of two adjacent magnet 31.

Specifically, in the detection process, a sample to be detected is added into the sample tube 40, and then a reactant containing micron-sized or nano-sized magnetic beads adsorbed with antigens or antibodies is added into the sample tube 40, wherein the magnetic beads are suspended in the reactant; the magnetic beads in the reagent can adsorb the target substances in the sample liquid, after adsorption is completed, the magnetic beads can be cleaned to remove unreacted samples and reagents in the reagent, a compound which takes the magnetic beads as solid phase carriers after reaction is obtained, and then immune substance detection in the next step is carried out.

The immunoassay analyzer further comprises a test tube mounting seat 50, wherein a positioning hole 51 for accommodating the sample tube 40 is formed in the test tube mounting seat 50, and when magnetic beads are cleaned, the test tube mounting seat 50 is driven by external force to rotate to drive the sample tube 40 to be cleaned to rotate to the position below the cleaning mechanism along with the test tube mounting seat 50, so that a plurality of magnets 31 which are closely arranged in a ring shape are arranged at the liquid height position of a sample to be detected in the sample tube 40; the sample tube 40 is disposed on the annular test tube holder 50 in an annular shape, and the plurality of magnets 31 are disposed around the sample tube 40 on the outer periphery or inner periphery of the sample tube 40.

Referring to fig. 3, each magnet 31 is a fan-shaped block structure, each magnet 31 includes an upper fan-shaped ring surface 311 and a lower fan-shaped ring surface (not shown) which are opposite to each other, an inner arc surface 314 and an outer arc surface 313 which are arranged inside and outside, and two end surfaces 315 which are arranged non-parallel and symmetrically, the two end surfaces 315 of each magnet 31 are closely attached to the end surface 315 of the adjacent magnet 31, the magnetization direction of each magnet 31 is radial magnetization, the inner arc surface 314 and the outer arc surface 313 of each magnet 31 are two polar end surfaces 315 of the magnet 31, and the magnetism of the inner arc surface 314 of the adjacent two magnets 31 is the same, so that a magnetic field can be formed between the end surfaces 315 of the adjacent two magnets 31, and the spherical microspheres in the sample tube 40 can perform directional motion under the effect of the magnetic field to be attached to the cup wall of the sample tube 40 on the side close to the magnet 31.

In the cleaning process, the cleaning mechanism moves downwards to extend into the bottom of the sample tube 40, and the residual sample to be detected and the unreacted reactant in the sample tube 40 are extracted; further, a cleaning solution is injected into the sample tube 40 through a cleaning mechanism to clean the complex having the magnetic beads as the solid phase carriers. When the sample tube 40 is close to the magnet 31, the magnetic beads move directionally under the action of the magnetic field formed by the magnet 31, so that the contact surface between the magnetic beads and the cleaning liquid is increased, impurities attached to the surfaces of the magnetic beads outside the cup wall can be removed, the cleaning liquid is drawn out after repeated cleaning for several times, and the cleaning process of the magnetic beads can be completed.

In the present embodiment, two end surfaces 315 of two adjacent magnets 31 are in close contact with each other, and the magnetic poles of the intrados surface 314/extrados surface 313 of two adjacent magnets 31 are the same. For example, both intrados 314 of two adjacent magnets 31 are N-pole or both intrados 314 of two adjacent magnets 31 are S-pole. In this way, two magnetic poles of the magnet 31 are arranged on the inner arc surface 314 and the outer arc surface 313, so that the polarities of the magnetic poles of the two adjacent magnets 31 contacted with the end surface 315 at the inner arc surface 314 and the outer arc surface 313 are the same, a high-strength magnetic field can be formed at the end surface 315 contacted with the two adjacent magnets 31, and therefore when a magnetic bead in the sample tube 40 is close to the adjacent end surface 315, stronger magnetic attraction force can be applied to the magnetic bead, the moving time of the magnetic bead is shortened, the time spent on the adhesion of the magnetic bead on the cup wall of the sample tube 40 is shortened, and the adsorption efficiency is improved.

Alternatively, the two end faces 315 of the magnet 31 with the sector-shaped block structure may be smooth planes perpendicular to the upper sector-shaped ring face 311 and the lower sector-shaped ring face 312, or may be non-smooth curved surfaces or planes with other shapes, as long as the end faces 315 of the two adjacent magnets 31 can be kept in close contact.

In the present embodiment, the magnetic separation assembly 30 is disposed on the outer periphery and/or the inner periphery of the sample tube 40, and when the sample tube 40 is at a predetermined position relative to the magnetic separation assembly 30, the magnetic separation assembly 30 can perform a magnetic separation operation on the sample tube 40.

Specifically, magnetic separation subassembly 30 is a plurality of magnet 31 of arranging around sample tube 40 ring form, and a plurality of magnet 31 are ring form and set up around the periphery or the inner periphery of sample tube 40, and magnet 31 corresponds to the high position setting that is used for holding the sample liquid that awaits measuring in sample tube 40, and the angle of the central angle of magnet 31 can be carried out manual or automatic adjustment according to the quantity of the sample test tube that awaits measuring, and the angle of every magnet 31 central angle can be 30 °, 45 °, 60 °, 90 ° or other arbitrary angles for example. In addition, in order to achieve a better magnetic separation effect and reduce the loss of magnetic beads in the washing process, a certain limitation needs to be imposed on the relative position of the sample tube 40 and the magnet 31 in the magnetic separation process. In the present application, the relative position between the sample tube 40 and the magnet 31 can be adjusted by physical limitation or software control to meet the requirement of magnetic separation, the specific structure of the physical limitation and the software control method are not particularly limited in the present application, and the method using the physical limitation or software control does not relate to the invention point, and is not described in detail in the present application.

For example, in the present application, the sample tube 40 can be driven by the sample holder 50 to perform a rotational motion, and in order to achieve a better separation effect, a certain limitation needs to be performed on the position of the sample tube 40 when the sample tube 40 stops moving on the sample holder 50, for example, an included angle between a connecting line between the center of the sample tube 40 and the center of the magnetic separation assembly 30 and an end surface of the two closely attached magnets 31 is limited to be less than or equal to one quarter of the central angle of the magnet 31 or 10 degrees.

In an embodiment of the present invention, as shown in fig. 4, the magnetic separation assemblies 30 are arranged around the outer circumference of the sample tube 40 in an annular shape to form the outer ring set 36, and an included angle θ 1 between a connecting line between the center of the sample tube 40 when stopping moving and the center of the outer ring set 36 and the corresponding two closely attached magnet end surfaces needs to be adjusted and set in a physical limiting or software control manner, which is less than one fourth or 10 degrees of the central angle of the magnet 31.

In another embodiment of the present invention, as shown in fig. 5, the magnetic separation assembly 30 is arranged around the inner circumference of the sample tube 40 in a ring shape to form the inner ring group 35, and an included angle θ 1 between a connecting line between the center of the sample tube 40 when stopping moving and the center of the inner ring group 35 and the corresponding two closely attached magnet end surfaces needs to be adjusted and set in a physical limiting or software control manner, which is less than one fourth or 10 degrees of the central angle of the magnet 31.

In another embodiment of the present invention, as shown in fig. 6, the magnetic separation assembly 30 is an inner ring set 35 formed around the inner circumference of the sample tube 40 and an outer ring set 36 formed around the outer circumference of the sample tube 40, the immunodetection analyzer can obtain the position of the sample tube 40 on the sample holder 50 when the sample tube 40 stops moving by photoelectric induction or other means, perform the magnetic separation operation directly when the positional relationship between the sample tube 40 and the inner and outer ring magnets satisfies the predetermined condition, and adjust the position of the sample tube 40 by means of physical limitation or software control when the predetermined condition is not satisfied, so as to satisfy the requirement of magnetic separation. Specifically, at least one of the angles between the connecting line of the center of the sample tube 40 and the center of the inner ring set 35 or the outer ring set 36 when stopping moving and the corresponding end surfaces of the two magnets 31 attached to each other needs to be adjusted and set in a physical limiting or software control manner to be smaller than one fourth or 10 degrees of the central angle of the magnets 31, and if both the angles are larger than one fourth or 10 degrees of the central angle of the magnets 31, the angle θ 3 between the center of the sample tube 40 when stopping moving and the corresponding end surfaces of the two magnets attached to each other in the inner ring set 35 or the angle θ 4 between the connecting line of the center of the outer ring set 36 and the corresponding end surfaces of the two magnets attached to each other needs to be adjusted and set in a physical limiting or software control manner to be smaller than one fourth or 10 degrees of the central angle of the magnets 31.

According to another embodiment of the present invention, as shown in fig. 7-12, two sets of magnets 31 are provided, and two sets of magnets 31 are oppositely spaced, wherein one set of magnets 31 is disposed around the inner circumference of the sample tube 40, and the other set of magnets 31 is disposed around the outer circumference of the sample tube 40; the two groups of magnets 31 are respectively formed by enclosing a plurality of magnets 31 into an inner ring group 35 and an outer ring group 36 which are arranged at intervals, and the inner ring group 35 and the outer ring group 36 are arranged in a concentric circle.

Preferably, the two sets of magnets 31 are disposed corresponding to the height position of the sample tube 40 for containing the sample liquid to be detected, and the heights of the two sets of magnets 31 are the same, and the upper sector ring surface 311 and the lower sector ring surface of the two sets of magnets 31 are flush.

Further, the angle of the central angle of at least some of magnets 31 of inner ring set 35 is the same as the angle of the central angle of corresponding magnets 31 of outer ring set 36, for example, the angle of the central angle of each magnet 31 may be 30 °, 45 °, 60 °, 90 °, or any other angle.

In all the embodiments described in the present application, the expression "at least part of magnets 31 of inner ring set 35" corresponds to "magnets 31 of outer ring set 36" means: as shown in fig. 6, the magnet 311 of the inner ring set 35 and the magnet 312 of the outer ring set 36 are in a corresponding state, and specifically, as shown in fig. 6, the magnet 311 of the inner ring set 35 has a first end face 3151 and a second end face 3152, and the magnet 312 of the outer ring set 36 has a third end face 3153 and a fourth end face 3154. A connecting line between the first end face 3151 and the center of the magnetic separation assembly is clamped between a connecting line between the third end face 3153 and the center of the magnetic separation assembly and a connecting line between the fourth end face 3154 and the center of the magnetic separation assembly, and a connecting line between the second end face 3152 and the center of the magnetic separation assembly is clamped outside a connecting line between the third end face 3153 and the center of the magnetic separation assembly and a connecting line between the fourth end face 3154 and the center of the magnetic separation assembly; when the included angle θ 5 formed by the second end surface 3152 and the third end surface 3153 and the central connecting line of the magnetic separation assembly is greater than or equal to one half of the central angle of the inner ring set magnet 311 and/or the outer ring set magnet 312, the magnet 31 of the inner ring set 35 and the magnet 31 of the outer ring set 36 are considered to be in a corresponding state; or when the first end face 3151 and the third end face 3153 overlap with the connecting line of the magnetic separation assembly center and the second end face 3152 and the fourth end face 3154 overlap with the connecting line of the magnetic separation assembly center, it is considered that the magnet 31 of the inner ring set 35 and the magnet 31 of the outer ring set 36 are in a corresponding state

Furthermore, end faces 315 of at least some of magnets 31 of inner ring set 35 are aligned with or offset from end faces 315 of corresponding magnets 31 of outer ring set 36. When end faces 315 of at least some magnets 31 of inner ring set 35 and end faces 315 of corresponding magnets 31 of outer ring set 36 are arranged in a staggered manner, an included angle formed by end faces 315 of at least some magnets 31 of inner ring set 35 and end faces 315 of corresponding magnets 31 of outer ring set 36 is smaller than one fourth of a central angle of a single magnet 31.

Optionally, when end faces 315 of at least some magnets 31 of inner ring set 35 and end faces 315 of corresponding magnets 31 of outer ring set 36 are disposed in a staggered manner, an included angle formed by end faces 315 of at least some magnets 31 of inner ring set 35 and end faces 315 of corresponding magnets 31 of outer ring set 36 is less than or equal to 10 degrees.

In another embodiment of the present invention, as shown in fig. 11, when end faces 315 of at least some of magnets 31 of inner ring set 35 are offset from end faces 315 of magnets 31 of corresponding outer ring set 36, end faces 315 of at least some of magnets 31 of inner ring set 35 are located on a bisector of a central angle of magnets 31 of corresponding outer ring set 36.

In another embodiment of the present invention, as shown in fig. 12, when end faces 315 of at least some of magnets 31 of inner ring set 35 and end faces 315 of magnets 31 of corresponding outer ring set 36 are disposed in a staggered manner, an included angle θ 6 formed by end faces 315 of at least some of magnets 31 of inner ring set 35 and a bisector of a central angle of magnets 31 of corresponding outer ring set 36 is smaller than one fourth of the central angle of magnets 31 or smaller than 10 degrees.

In one embodiment of the present invention, two sets of magnets 31 are disposed around the sample tube 40 in the same horizontal plane, and the inner arc surface 314 of the outer ring set 36 and the outer arc surface 313 of the inner ring set 35 have the same or opposite magnetic poles.

Specifically, the inner arc surface 314 of the outer ring set 36 may be an S pole, and the outer arc surface 313 of the inner ring set 35 may be an N pole; or the inner arc surface 314 of the outer ring set 36 may be an S pole, and the outer arc surface 313 of the inner ring set 35 may be an S pole.

According to another embodiment of the present invention, the magnet 31 used in the present application may be a permanent magnet or a soft magnet, the permanent magnet may be any one of samarium cobalt magnet, neodymium iron boron magnet, ferrite magnet, alnico magnet, and iron chromium cobalt magnet, and the soft magnet may be an electromagnet.

In summary, as those skilled in the art can easily understand, in the magnetic separation assembly 30 provided in the present application, the plurality of magnets 31 closely arranged in a ring shape are formed on the same plane, a magnetic field is formed at the end surface 315 where adjacent magnets 31 are closely arranged, and when a magnetic bead in the sample tube 40 is close to the end surface 315, a magnetic attraction force can be applied to the magnetic bead through the magnetic field, so that the adsorption time and the cleaning time in the magnetic separation process can be shortened; meanwhile, the magnets 31 are closely arranged in a ring shape, so that the arrangement among the magnets 31 is more compact, the magnetic separation operation can be simultaneously carried out on a plurality of sample tubes 40, the magnetic separation efficiency can be improved, and the device is simple in structure, compact in size and convenient to use and maintain.

The above embodiments are merely examples and are not intended to limit the scope of the present disclosure, and all modifications, equivalents, and flow charts using the contents of the specification and drawings of the present disclosure, which are directly or indirectly applied to other related technical fields, are included in the scope of the present disclosure.

Claims (13)

1. The magnetic separation assembly is characterized by comprising a plurality of magnets, wherein the magnets are arranged in a ring shape on the same plane in a clinging mode.

2. The magnetic separator assembly according to claim 1, wherein each of the plurality of magnets is flat and has a through hole for fixing in a thickness direction.

3. The magnetic separation assembly of claim 1, wherein each of the magnets has a fan-shaped ring-shaped structure, each of the magnets includes an upper fan ring surface and a lower fan ring surface that are opposite to each other, an inner arc surface and an outer arc surface that are arranged inside and outside, and two end surfaces that are arranged non-parallel and symmetrically, the two end surfaces of each of the magnets are tightly attached to the end surfaces of the adjacent magnets, the magnetization direction of the magnets is radial magnetization, and the inner arc surface and the outer arc surface are two polar end surfaces of the magnets.

4. The magnetic separation assembly of claim 3, wherein the magnetic separation assembly is disposed at an outer periphery and/or an inner periphery of a sample tube, and when the sample tube is at a predetermined position relative to the magnetic separation assembly, the magnetic separation assembly is capable of performing a magnetic separation operation on the sample tube; the preset position is that an included angle between a connecting line of the center of the sample tube and the center of the magnetic separation assembly and the corresponding end faces of the two magnets which are tightly attached to each other is less than or equal to one fourth of the central angle of the magnets or 10 degrees.

5. The magnetic separation assembly of claim 3 wherein a plurality of said magnets define spaced inner and outer sets of rings, said inner and outer sets of rings being arranged in concentric circles.

6. The magnetic separation assembly of claim 5, wherein the angle of the central angle of at least some of the magnets of the inner ring set is the same as the angle of the central angle of the corresponding magnets of the outer ring set.

7. The magnetic decoupling assembly of claim 6, wherein the end surfaces of at least some of the magnets of the inner ring set are aligned with or offset from the corresponding end surfaces of the magnets of the outer ring set.

8. The magnetic separation assembly of claim 7, wherein when the end surfaces of at least some of the magnets of the inner ring set are offset from the end surfaces of the corresponding magnets of the outer ring set, the included angle formed by the end surfaces of at least some of the magnets of the inner ring set and the end surfaces of the corresponding magnets of the outer ring set is less than or equal to one quarter of the central angle of the magnets.

9. The magnetic separation assembly of claim 7, wherein when the end surfaces of at least some of the magnets of the inner ring set are offset from the end surfaces of the corresponding magnets of the outer ring set, the included angle formed by the end surfaces of at least some of the magnets of the inner ring set and the end surfaces of the corresponding magnets of the outer ring set is less than or equal to 10 degrees.

10. The magnetic separation assembly of claim 7, wherein when the end surfaces of at least some of the magnets of the inner ring set are offset from the corresponding end surfaces of the magnets of the outer ring set, the bisectors of the central angles of at least some of the magnets of the inner ring set are flush with the end surfaces of the magnets of the outer ring set for abutting against each other.

11. The magnetic separation assembly of claim 7, wherein when the end faces of at least some of the magnets of the inner ring set are offset from the end faces of the corresponding magnets of the outer ring set, the included angle formed by the bisector of the central angle of at least some of the magnets of the inner ring set and the end faces of the corresponding magnets of the outer ring set is less than or equal to 10 degrees.

12. A magnetic separation assembly according to claims 8-11,

the inner arc surface of the outer ring group is an S pole, and the outer arc surface of the inner ring group is an N pole; or alternatively

The inner arc surface of the outer ring group is an S pole, and the outer arc surface of the inner ring group is an S pole.

13. An immunoassay analyzer, which is characterized by comprising a sample feeding gripper and the magnetic separation assembly of any one of claims 1 to 9, wherein the sample feeding gripper is used for gripping a sample tube to be placed at the close joint of two adjacent magnets for magnetic separation.

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