CN114574284B - Cedar essential oil, compound Cedar essential oil, extraction method and application thereof - Google Patents
Cedar essential oil, compound Cedar essential oil, extraction method and application thereof Download PDFInfo
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- CN114574284B CN114574284B CN202011380757.XA CN202011380757A CN114574284B CN 114574284 B CN114574284 B CN 114574284B CN 202011380757 A CN202011380757 A CN 202011380757A CN 114574284 B CN114574284 B CN 114574284B
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/027—Recovery of volatiles by distillation or stripping
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0026—Essential oils; Perfumes compounds containing an alicyclic ring not condensed with another ring
- C11B9/003—Essential oils; Perfumes compounds containing an alicyclic ring not condensed with another ring the ring containing less than six carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0026—Essential oils; Perfumes compounds containing an alicyclic ring not condensed with another ring
- C11B9/0034—Essential oils; Perfumes compounds containing an alicyclic ring not condensed with another ring the ring containing six carbon atoms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Fats And Perfumes (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention provides cedar essential oil, compound cedar essential oil, and an extraction method and application thereof. The extraction method of the cedar essential oil comprises the following steps: refining the crude cedar essential oil by a molecular distillation method, and collecting residual liquid to obtain cedar essential oil; the cedar essential oil crude product comprises the following components in mass content: 11-14% of alpha-cedrene, 7-9% of gamma-cedrene, 30-32% of beta-cedrene, 1-2% of 1, 4-cedrene, 4-6% of cis-gamma-atlantic ketone, 5-7% of trans-gamma-atlantic ketone, 0.5-2% of cedrol and 0.8-1.5% of cedrone; in the molecular distillation method, the evaporation temperature is 40-80 ℃, and the feeding flow rate is 0.5-10 mL/min. The cedar essential oil obtained by the extraction method has higher content of beneficial components, and can relieve anxiety emotion and have remarkable repairing effect on stress skin barrier damage after being compounded with the base oil.
Description
Technical Field
The invention relates to cedar essential oil, compound cedar essential oil, and an extraction method and application thereof.
Background
The rapid pace and high efficiency of modern society inevitably brings much tension and pressure to people. People seek products that can help them relax to maintain a healthy lifestyle. An increasing number of women are interested in cosmetic care products that relieve anxiety and stress, and have a relaxing effect. Previous studies have also shown that psychological stress may be associated with the onset or exacerbation of a variety of skin conditions. Aromatherapy is an overall treatment, generally a treatment that uses essential oils containing fragrances extracted from therapeutic plants to enhance mental function. It is a natural therapy using plants, and is widely performed in the form of massage, inhalation, hot compress, bath, foot bath, etc. In recent years, a number of fragrance-related cosmetics have become increasingly popular, and aromatic essential oils have been used to enhance physical and emotional well-being, as well as related fields and industries.
Cedar essential oils have been used in traditional aromatherapy for a long time to treat various diseases such as antisepsis and anti-inflammation, soothing tension, etc. The traditional Chinese medicine considers that the cedar has the effects of dispelling wind and activating collaterals, relieving swelling and promoting granulation, and activating blood and stopping bleeding. Cedar bark in indian traditional medicine has obvious therapeutic effects on inflammation, arthralgia and dermatosis. Cedar essential oils are also widely used by the egyptians. Modern researches have shown that cedar essential oil plays a major role in aromatherapy for treating alopecia. In addition, cedar has the antioxidant property, can remove free radicals, is a powerful antioxidant, and has various effects of resisting tumor, oxidation, inflammation, cancer, memory, bacteria, virus and the like. Researches report that the celiac injection of cedar essential oil of Virginia and the main active ingredient of cedar alcohol have the anti-anxiety effect.
However, most of cedar essential oil sold in the market at present is not clear in source, and the cedar essential oil can refer to Himalayan cedar (Cedrus deodara), atlantic cedar (Cedrus atlantica), north America juniper also called Virginia cedar (Juniperus virginiana) or other coniferae plants, and the essential oil is not clear in component and cannot control the quality.
Himalayan cedar (C.deodara) is also known as cedar, tower pine or cedar, and is native to Himalayan mountain, distributed in African sweat to India, and at an altitude of 1300-3300 meters. The tree shape is evergreen throughout the year, beautiful, and is widely cultivated as a garden tree. Resin, fragrance and durability; can be used for building, bridge, ship building, furniture and appliances.
Chinese patent document CN110123848A discloses a cedar essential oil capable of improving symptoms such as depression anxiety and the like, and specifically discloses a cedar essential oil which is prepared by fermenting, leaching, carrying out enzymolysis and extraction on cedar needles, carrying out supercritical carbon dioxide extraction on the mixed solution after enzymolysis in an extraction method, collecting essential oil, refining the essential oil by a molecular distillation instrument, wherein the feeding temperature is 40-45 ℃, the sample injection speed is 480-530 mL/h, the first-stage evaporation temperature is 110-115 ℃, the second-stage evaporation temperature is 60-65 ℃, and collecting the second-stage distillation part. The cedar essential oil in the patent comprises the following components in percentage by weight: alpha-plexes Bo Renxi% and gamma-cis-cedrene 3% by weight. However, the cedar essential oil obtained by adopting the refining method in the patent has higher content of the non-beneficial components and lower content of the beneficial components. The total content of cedrene in the patent document is lower, but the content of alpha-plexene Bo Renxi which is unpleasant to human is far higher than that of cedrene substances, and the higher content of alpha-cedrene brings opposite effects, so that the anti-anxiety effect of cedrene essential oil obtained in the patent document is poor. At present, the technical problems are still to be solved.
Disclosure of Invention
The invention mainly aims to overcome the defects of the prior art that the cedar essential oil obtained by the cedar essential oil extraction method has more content of non-beneficial components and poor antidepressant effect of the final cedar essential oil, and provides the cedar essential oil, the compound cedar essential oil, the extraction method and the application thereof. The cedar essential oil obtained by the extraction method has higher content of beneficial components, can relieve anxiety emotion by compounding with the base oil, and has obvious repairing effect on stress skin barrier damage.
The invention mainly solves the technical problems through the following technical scheme.
The invention provides a cedar essential oil extraction method, which comprises the following steps: refining the crude cedar essential oil by a molecular distillation method, and collecting residual liquid to obtain the cedar essential oil;
The cedar essential oil crude product comprises the following components in mass content: 11-14% of alpha-cedrene, 7-9% of gamma-cedrene, 30-32% of beta-cedrene, 1-2% of 1, 4-cedrene, 4-6% of cis-gamma-atlantic ketone, 5-7% of trans-gamma-atlantic ketone, 0.5-2% of cedrons, 0.8-1.5% of cedrons, 1.5-3% of cis-alpha-atlantic ketone and 10-12% of trans-atlantic ketone, wherein the percentages are mass percentages of each component accounting for the total mass of the cedar essential oil crude product;
In the molecular distillation method, the evaporation temperature is 40-80 ℃;
In the molecular distillation method, the feeding flow rate is 0.5-10 mL/min.
In the present invention, the residual liquid means a heavy fraction collected by the molecular distillation method, that is, a substance other than the collected condensate. The prior art is aware of the waxy and other macromolecular components in the heavy fraction, which cause oxidative deterioration and off-flavor of cedar essential oil. However, experiments show that the molecular distillation method removes light fraction, and the obtained heavy fraction can obviously modify the sniffing experience of cedar essential oil, and has the effects of resisting anxiety and obviously repairing the stress skin barrier damage.
The crude cedar essential oil product in the invention is preferably free of alpha-kowtow Bo Renxi through GCMS detection.
In a preferred embodiment of the present invention, the crude cedar essential oil comprises the following components in mass content: alpha-cedrene 12.56%, gamma-cedrene 7.89%, beta-cedrene 31.2%, 1, 4-cedrene 1.4%, cis-gamma-atlantic ketone 4.63%, trans-gamma-atlantic ketone 5.9%, cedarwood alcohol 0.83%, cedrone 1.11%, cis-alpha-atlantic ketone 2.11% and trans-atlantic ketone 10.87%, the percentages being mass percentages of each component to the total mass of the cedar essential oil crude product.
In the invention, the cedar essential oil crude product can be prepared by a steam distillation method of Himalayan cedar (Cedrus deodara), for example.
Wherein, the Himalayan cedar generally adopts branches and leaves or trunks of the Himalayan cedar.
Wherein the steam distillation method can be a steam distillation method conventional in the art.
In the steam distillation method, the distillation time may be, for example, 2 to 4 hours.
In the steam distillation method, the volume ratio of the himalayan cedar to the water may be, for example, 1: (10-30), e.g., 1:20.
Wherein, the person skilled in the art knows that the himalayan cedar is subjected to the steam distillation method to obtain an oil-water mixture, the oil-water mixture is usually layered, and the upper essential oil is collected to obtain the cedar essential oil crude product. Wherein, the layering is generally achieved by standing. The upper essential oil is also typically dried over anhydrous sodium sulfate to remove residual moisture.
In the invention, the evaporation temperature refers to the evaporation temperature of 40-80 ℃ in the whole molecular distillation method. Namely, the molecular distillation method is a one-step distillation method, is more convenient and quicker, and is different from the first-stage evaporation temperature and the second-stage evaporation temperature in the background art.
In the present invention, the evaporation temperature is preferably 50 to 70 ℃, for example 60 ℃.
In the present invention, the feed flow rate is preferably 0.5 to 2mL/min, for example 1mL/min.
In the molecular distillation method of the present invention, the condensing temperature is set with reference to a condensing temperature conventionally used in the art, preferably 8 to 12℃such as 10 ℃.
In the molecular distillation method of the present invention, the vacuum degree is set with reference to the vacuum degree conventional in the art, and is preferably 5 to 20mbar, for example, 10mbar.
In the molecular distillation method of the present invention, the number of revolutions per minute of the film may be referred to as a number of revolutions per minute of the film, which is conventional in the art, and is preferably 100 to 200rpm, for example 140rpm.
The invention provides cedar essential oil which is prepared by adopting the extraction method.
The invention also provides cedar essential oil, which comprises the following components in percentage by weight: 9.5 to 11 percent of alpha-cedrene, 6 to 8 percent of gamma-cedrene, 28 to 30 percent of beta-cedrene, 0.8 to 2 percent of 1, 4-cedrene, 4 to 6 percent of cis-gamma-atlantic ketone, 6 to 8 percent of trans-gamma-atlantic ketone, 0.5 to 2 percent of cedrol, 0.8 to 2 percent of cedrons, 1.5 to 3.5 percent of cis-alpha-atlantic ketone and 11 to 14 percent of trans-atlantic ketone, and the percentages are the mass percentages of each component accounting for the total mass of the cedar essential oil.
Through GCMS detection, the cedar essential oil disclosed by the invention does not contain alpha-kowtow Bo Renxi.
In a preferred embodiment of the present invention, the cedar essential oil comprises the following components in percentage by weight: 10.28% of alpha-cedrene, 7.04% of gamma-cedrene, 28.84% of beta-cedrene, 1.24% of 1, 4-cedrene, 5.34% of cis-gamma-atlantic ketone, 6.76% of trans-gamma-atlantic ketone, 1.05% of cedrons, 1.37% of cedrons, 2.61% of cis-alpha-atlantic ketone and 12.4% of trans-atlantic ketone, and the percentages are mass percentages of each component based on the total mass of the cedar essential oil.
The invention provides a compound cedar essential oil which comprises the following components in parts by mass: 0.5 to 1 percent of cedar essential oil;
The jojoba oil accounts for 99 to 99.5 percent, and the percentage is the mass percentage of each component accounting for the total mass of the compound cedar essential oil.
In the invention, the content of the cedar essential oil is preferably 0.5-0.8%.
In the invention, the compound cedar essential oil also preferably comprises one or more of hinoki essential oil, rose geranium essential oil, sclareum essential oil and bergamot essential oil, preferably rose geranium essential oil or bergamot essential oil.
Wherein the content of the juniper essential oil in North America is preferably 0.2-0.5%, preferably 0.5%, and the percentage is mass percentage of the total mass of the compound cedar essential oil.
The content of the rose geranium essential oil is preferably 0.2-0.5%, preferably 0.2%, and the percentage is the mass percentage of the total mass of the compound cedar essential oil.
Wherein the content of the sclareum essential oil is preferably 0.2-0.5%, preferably 0.2%, and the percentage is mass percentage of the total mass of the compound cedar essential oil.
The content of the bergamot essential oil is preferably 0.2-0.5%, preferably 0.2%, and the percentage is the mass percentage of the total mass of the compound cedar essential oil.
In the invention, the compound cedar essential oil can be prepared by adopting a conventional preparation method in the field, and the components are generally mixed to obtain the cedar essential oil.
The invention also provides application of the compound cedar essential oil in preparing products for repairing the barrier function of the stratum corneum or resisting anxiety.
On the basis of conforming to the common knowledge in the field, the above preferred conditions can be arbitrarily combined to obtain the preferred examples of the invention. The reagents and materials used in the present invention are commercially available.
The invention has the positive progress effects that: according to the invention, crude himalayan cedar essential oil is obtained through steam distillation, and then a specific molecular distillation method is combined to remove light fraction and collect heavy fraction which is obtained as cedar essential oil. After the cedar essential oil is compounded with the base oil, brain wave analysis and salivary cortisol level detection prove that the cedar essential oil has better effect of relieving anxiety and emotion, and the restoration rate of the percutaneous water loss value confirms that the cedar essential oil has remarkable restoration effect on stress skin barrier damage.
Drawings
Fig. 1 is a graph showing the change of the alpha/beta ratio of brain waves before and after sniffing by the compound cedar essential oil of example 4.
Fig. 2 is the effect of the compounded cedar essential oil of example 4 on salivary cortisol after sniffing.
Fig. 3 is the effect of the compounded cedar essential oil of example 4 on recovery of skin TEWL after sniffing.
Detailed Description
The invention is further illustrated by means of the following examples, which are not intended to limit the scope of the invention. The experimental methods, in which specific conditions are not noted in the following examples, were selected according to conventional methods and conditions, or according to the commercial specifications.
All commercial sources of the raw materials in the following examples are as follows:
himalayan cedar (Cedrus deodara) is produced in the south of the Tibetan, sichuan, southwest of Yunnan, and India or Nepal of China.
Jojoba oil: INCA OIL SA
The juniper, rose pelargonium, sclareum and bergamot essential oils were all purchased from the flavor and fragrance company of france Xia Labo (Charabot).
Example 1
(1) The extraction method of the Himalayan cedar essential oil comprises the following steps:
Preparing a crude product of Himalayan cedar essential oil: collecting fresh branches and leaves of Cedar (Cedrus deodara), cleaning, cutting with scissors, and placing into steam distillation device. Adding distilled water with the volume of 20 times, distilling for 4 hours to obtain an oil-water mixture, standing for layering, collecting upper-layer essential oil, and drying by adopting anhydrous sodium sulfate to obtain yellowish green transparent liquid which is crude product of Himalayan cedar essential oil, wherein the yield is 0.5%.
(2) And refining the crude himalayan cedar essential oil by adopting a molecular distillation method. The refining method comprises the following steps:
Instrument: KDL2 molecular distillation apparatus (UIC company, germany); evaporator heating temperature (i.e., evaporation temperature): 60 ℃; the vacuum degree of the system is 10mbar; the film scraping rotating speed is 140rpm; the feeding flow rate is 1mL/min; the condenser temperature is 10 ℃; the above conditions remained unchanged throughout the molecular distillation operation, and the residue (heavy fraction) and condensate (light fraction) were collected, wherein the residue was cedar essential oil in this example.
Examples 2 to 6 the ingredients of the compounded cedar essential oils are shown in table 1 below, and cedar essential oils in table 1 refer to the above-mentioned collected residual liquids.
TABLE 1
| Sample numbering | Composition and content (mass%) of compound essential oil |
| Example 2 | Cedar essential oil 0.5, jojoba oil 99.5 |
| Example 3 | Cedar essential oil 0.5, jojoba oil 99, juniper essential oil 0.5 |
| Example 4 | Cedar essential oil 0.8, jojoba oil 99, rose geranium essential oil 0.2 |
| Example 5 | Cedar essential oil 0.8, jojoba oil 99, sclareum essential oil 0.2 |
| Example 6 | Cedar essential oil 0.8, jojoba oil 99, bergamot essential oil 0.2 |
The preparation method of the compound essential oil comprises the following steps: the components are mixed according to the proportion shown in the table 1, and are placed in a brown glass bottle for refrigeration and preservation at 4 ℃.
Effect example 1
1. Gas Chromatography Mass Spectrometry (GCMS) analysis of cedar essential oil and crude product thereof
The testing method comprises the following steps: instrument: gas chromatograph-mass spectrometer of Agilent company 7890B-5977A of America; chromatographic column: DB-WAX (30 m.times.250 μm.times.0.25 μm), carrier gas: helium 99.999%; sample injection amount: 0.2 μl; split ratio: 100/1; column temperature: maintaining at 50deg.C for 3min, then increasing to 120deg.C at 4deg.C/min for 10min, and increasing to 220deg.C at 2deg.C/min for 2min; sample inlet temperature: 260 ℃; ion source temperature: 230 ℃; four-stage bar temperature: 150 ℃; ionization mode: ei+,70eV; detector voltage: 2047V; scanning mode: full scanning; carrier gas flow rate: 1mL/min. Mass range m/z 33-350; NIST2014 library. The test results are shown in the following tables 2 and 3, and Table 2 shows the yields of the light and heavy fractions obtained by the molecular distillation method, and Table 3 shows the analysis results of GCMS in the extracted light and heavy fractions and the crude cedar essential oil.
TABLE 2 molecular distillation yield of the Components (mass%)
| Component (A) | Yield (wt%) | Smell of |
| Light fraction | 15 | The pine wood has pungent smell |
| Heavy fraction | 85 | Pine wood with soft smell |
TABLE 3 GCMS results for crude cedar essential oils and fractions
As is clear from the above table, the crude product of Himalayan cedar essential oil, the light fraction and the heavy fraction in this example do not contain alpha-tap Bo Renxi. Meanwhile, after molecular distillation, the proportion of olefins in the heavy fraction of the Himalayan cedar essential oil is increased, and the proportion of ketone components is increased.
2. Investigation of preference of compound cedar essential oil
Investigation of the preference of the compound cedar essential oil of examples 2 to 6 by means of questionnaire: 66 volunteers (20-40 years old women) were randomly collected, a proper amount of the compound cedar essential oil was dipped in a fragrance-smelling strip, the mixture was naturally sniffed for 5s at a position of 2-3cm below the nose, and the relaxing effect and preference degree of the compound cedar essential oil of examples 2-6 were scored (1-5 points) according to the subjective feeling of the volunteers after sniffing the essential oil as a faithful answer questionnaire. Results single factor analysis of variance was performed using Excel software and the test data are shown in table 4 below.
Table 4 preference investigation of the formulated cedar essential oils of examples 2-6 (n=66)
The results show that the example 4 formulated cedar essential oil is significantly improved over the other examples in table 4. The smell is more relaxed, calm and relaxed, and the preference is highest, so that the method is selected as a subsequent experiment.
3. Influence of sniffing compound cedar essential oil on brain waves
Electroencephalogram (electroencephalogram, EEG) is a widely used brain wave measurement device that reflects brain neural activity based on changes over time in minute potentials generated by the brain itself during brain neural activity. The human brain waves mainly include alpha waves (the frequency is 8-13Hz, the amplitude is 10-100 μV), beta waves (the frequency is over 13Hz, the amplitude is 5-20 μV), theta waves (the frequency is 4-8Hz, the amplitude is 20-200 μV), delta waves (the frequency is less than 4Hz, the amplitude is more than 200 μV), and the like. Wherein the alpha wave is more in calm eye, and disappears when the emotion is tension, thinking problem or eyes are open. In sedative or emotional stress, the beta wave increases and the amplitude increases. According to the changes of electroencephalogram amplitude, frequency and the like, the changes of brain emotion can be reflected, and researches report that patients with anxiety disorder can show weakening or disappearance of brain wave alpha rhythms and increase of beta waves. In recent years, research on the observation of electroencephalogram and the sensory of human has progressed rapidly, and many studies have been attempted to quantitatively and objectively evaluate the effect of essential oil using electroencephalogram test in the cosmetic industry.
A total of 12 healthy females, 20-40 years old, were recruited as volunteers, informed of the experimental content, and after informed consent was obtained and signed, the follow-up experiment was continued. The volunteer sits on the chair in the most comfortable posture, sits still for 30min, and then uses an electroencephalograph (ANT Neuro eegomini EE-401) to monitor 8 channels of data simultaneously, and an electrode cap is worn on the head of the volunteer, firstly, the ground level (GND) is connected with the reference level (REF), and then the other 8 points Fz, cz, pz, F3, F4, fpz, C3 and C4 are connected. And starting to monitor brain waves in a whole-course eye closing way. The basic data of brain waves of volunteers are collected, then an experimenter dips a proper amount of compound cedar essential oil of example 4 by a fragrance smelling strip according to a random sequence, the volunteers naturally sniff at a position 2-3cm below the nose, sniffing is performed for 3 minutes between different essential oils, and brain wave data after sniffing and neutralization are collected before sniffing. Brain wave data analysis was performed using Asalab software and paired t-test was performed on the data using excel software. As shown in fig. 1, sniffing the brain wave α/β ratio change (n=12) p++0.05 before and after the compound cedar essential oil of example 4; * P is less than or equal to 0.01. The figure shows that the alpha/beta wave ratio of each channel is obviously reduced after the cedar essential oil is smelled, which suggests that the cedar essential oil has the function of relieving tension emotion.
4. Influence of sniffing compound cedar essential oil on skin barrier repair and salivary cortisol
Stress and anxiety can cause the rise of serum Cortisol (CORT) content of the organism, stress and anxiety can cause the rise of serum cortisol content of the organism, stress is transient response to the external environment, transient rise of serum free cortisol and salivary cortisol level can be caused, anxiety is a psychological characteristic of people, and is in a long-term state, and serum free cortisol and salivary cortisol basal secretion of anxiety patients is higher than that of normal people. Wherein, the analysis technology of salivary cortisol level is simple and easy to implement, and the possible increase of serum free cortisol-overactivity of a tester caused by the stress action of venipuncture is avoided. At the same time, the salivary cortisol level can better reflect the condition of serum free cortisol.
Transdermal water loss (TEWL), also known as transdermal water loss, represents the loss of water in the deep dermis through evaporation of the epidermis, an important parameter describing the skin barrier. The higher TEWL value indicates more water is lost through the skin and poorer barrier function of the stratum corneum.
A total of10 healthy females aged 20-40 were recruited as volunteers and informed of the experimental content, informed of their consent and continued with informed consent. The subject entered the room, washed the forearm, and marked the test area (2.5 cm x 2.5 cm) inside the wrist of the forearm of the volunteer. Volunteers were sitting still in the constant temperature and humidity chamber for more than 30min. Volunteer saliva (S1) was collected and TEWL values were determined and set as basal (Tb) values. The volunteer arm mark area was then peeled off with a glass tape for 20 times, and the TEWL value was measured and set to T0 value. Dipping a proper amount of essential oil with a fragrance-smelling strip, naturally sniffing at the position 2-3cm below the nose, and keeping the total sniffing time of the essential oil for 1.5 hours. The intermediate uses ENCEPHALAPP software to set up the Stroop word test to apply a certain mental stress to the volunteers for 30 minutes, and then the saliva of the volunteers is collected (S2). After 1.5h of the essential oil sniffing, the TEWL value was determined and this was set as recovery value (T1.5), while the volunteer saliva was collected (S3). The same volunteers were subjected to 2 tests, respectively, including jojoba oil (blank group in fig. 3) as a blank control and the compound cedar essential oil of example 4 (compound cedar essential oil group in fig. 3), the sniffing order of the essential oils and the test order of the left and right arms were random. The recovery rate of TEWL is calculated according to the formula: TEWL recovery (%) = (T0-T1.5)/(T0-Tb) ×100%. Determining the salivary cortisol level by using an enzyme-linked immunosorbent assay (ELISA) kit, and calculating the change rate of the salivary cortisol according to a formula: the rate of change= (Sn-S1)/S1 is 100%. The data were paired with t-test using excel software.
The effect of sniffing the compounded cedar essential oil of example 4 on salivary cortisol (n=10) is shown in fig. 2, p+.0.05. The blank group in fig. 2 is jojoba oil as a blank control, and the compound cedar essential oil group is the compound cedar essential oil in example 4. From the figure, the cortisol content in saliva is increased after pressure is applied, and the cortisol level in saliva smelling the cedar essential oil group is obviously reduced, so that the cedar essential oil group has the effect of relieving tension. As can be seen from fig. 2, the rate of change of cortisol was 3.09% at 0.5 hours after sniffing of the blank, and 3.15% at 1.5 hours after sniffing. After sniffing the compounded cedar essential oil of example 4, the rate of change of cortisol was-0.49% 0.5 hours after sniffing and-0.17% after sniffing for 1.5 hours.
Fig. 3 shows the effect of sniffing the recovery rate of the compounded cedar essential oil of example 4 on skin TEWL (n=10), p+.0.05. From the graph, after the cedar essential oil is smelled, the TEWL recovery rate after skin injury is obviously improved. It is suggested that sniffing the cedar essential oil can help skin barrier repair. As can be seen from fig. 3, the recovery rate of TEWL after sniffing the compounded cedar essential oil of example 4 was 40% and the blank group was 56%.
By combining the results, the compound cedar essential oil obtained by the molecular distillation method can obviously improve the sniffing experience of the cedar essential oil. The compound cedar essential oil is smelled, has the effect of relieving anxiety and emotion, and can promote the repair of the damage of the stress skin barrier.
Claims (6)
1. The extraction method of the cedar essential oil is characterized by comprising the following steps of: refining the crude cedar essential oil by a molecular distillation method, and collecting residual liquid to obtain the cedar essential oil;
(1) The preparation method of the cedar essential oil crude product comprises the following steps: taking fresh Himalayan cedar branches and leaves, cleaning, shearing by scissors, putting into a steam distillation device, adding distilled water with 20 times of volume, distilling for 4 hours to obtain an oil-water mixture, standing for layering, collecting upper-layer essential oil, and drying by using anhydrous sodium sulfate to obtain light yellow green transparent liquid which is crude Himalayan cedar essential oil, wherein the yield is 0.5%;
The cedar essential oil crude product comprises the following components in mass content: 11-14% of alpha-cedrene, 7-9% of gamma-cedrene, 30-32% of beta-cedrene, 1-2% of 1, 4-cedrene, 4-6% of cis-gamma-atlantic ketone, 5-7% of trans-gamma-atlantic ketone, 0.5-2% of cedar alcohol, 0.8-1.5% of cedar ketone, 1.5-3% of cis-alpha-atlantic ketone and 10-12% of trans-atlantic ketone, wherein the percentages are mass percentages of each component accounting for the total mass of the cedar essential oil crude product;
(2) Refining the crude himalayan cedar essential oil by adopting a molecular distillation method, wherein the refining method comprises the following steps of:
Instrument: a KDL2 molecular distillation apparatus; evaporating temperature: 60 ℃; the vacuum degree of the system is 10mbar; the film scraping rotating speed is 140rpm; the feeding flow rate is 1mL/min; condensing temperature is 10 ℃; the conditions are kept unchanged in the whole molecular distillation operation process, the residual liquid, namely the heavy fraction, is collected, the condensate, namely the light fraction, is collected, and the residual liquid is the cedar essential oil;
The cedar essential oil comprises the following components in percentage by weight: 9.5-11% of alpha-cedrene, 6-8% of gamma-cedrene, 28-30% of beta-cedrene, 0.8-2% of 1, 4-cedrene, 4-6% of cis-gamma-atlantic ketone, 6-8% of trans-gamma-atlantic ketone, 0.5-2% of cedarwood alcohol, 0.8-2% of cedrons, 1.5-3.5% of cis-alpha-atlantic ketone and 11-14% of trans-atlantic ketone, and the percentages are mass percentages of each component accounting for the total mass of the cedar essential oil.
2. The extraction method of cedar essential oil as claimed in claim 1, wherein the cedar essential oil crude product comprises the following components in mass content: alpha-cedrene 12.56%, gamma-cedrene 7.89%, beta-cedrene 31.2%, 1, 4-cedrene 1.4%, cis-gamma-atlantic ketone 4.63%, trans-gamma-atlantic ketone 5.9%, cedarwood alcohol 0.83%, cedrone 1.11%, cis-alpha-atlantic ketone 2.11% and trans-atlantic ketone 10.87%, the percentages being mass percentages of each component to the total mass of the cedar essential oil crude product.
3. The method for extracting cedar essential oil as claimed in claim 1, wherein the cedar essential oil comprises the following components in percentage by weight: 10.28% of alpha-cedrene, 7.04% of gamma-cedrene, 28.84% of beta-cedrene, 1.24% of 1, 4-cedrene, 5.34% of cis-gamma-atlantic ketone, 6.76% of trans-gamma-atlantic ketone, 1.05% of cedrons, 1.37% of cedrons, 2.61% of cis-alpha-atlantic ketone and 12.4% of trans-atlantic ketone, and the percentages are mass percentages of each component based on the total mass of the cedar essential oil.
4. A cedar essential oil characterized in that it is prepared by the extraction method of cedar essential oil as claimed in any one of claims 1-3.
5. The compound cedar essential oil is characterized by comprising the following components in parts by mass: 0.8% cedar essential oil as in any of claims 1-4; 99% of jojoba oil, 0.2% of rose geranium essential oil, and the percentage is the mass percentage of each component in the total mass of the compound cedar essential oil.
6. Use of the formulated cedar essential oil of claim 5 in the preparation of a product for repairing stratum corneum barrier function or anxiolytic.
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