CN114569801A - Controlled-degradation zinc-based beauty treatment line and preparation method thereof - Google Patents
Controlled-degradation zinc-based beauty treatment line and preparation method thereof Download PDFInfo
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/086—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C22/00—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
- C23C22/05—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
- C23C22/06—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH less than 6
- C23C22/07—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH less than 6 containing phosphates
- C23C22/08—Orthophosphates
- C23C22/22—Orthophosphates containing alkaline earth metal cations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
Abstract
The application relates to the technical field of medical cosmetology, and particularly discloses a zinc-based beauty treatment line with controllable degradation and a preparation method thereof, wherein the beauty treatment line comprises a zinc-based beauty treatment line substrate and an inorganic magnesium phosphate coating, and the zinc-based beauty treatment line substrate is processed from a zinc material; the inorganic magnesium phosphate coating is obtained by carrying out in-situ modification on a zinc-based beauty line matrix by using magnesium salts and phosphate under an acidic condition; the beauty line obtained by the scheme has excellent mechanical property, good heat resistance and corrosion resistance and low requirement on storage and transportation conditions. The application also provides a preparation method of the zinc-based beauty line with controllable degradation, which adopts zinc materials as raw materials, prepares a beauty line matrix through steps of turning, cutting, extruding, drawing, impressing and the like, and obtains the zinc-based beauty line containing the coating through partially modifying the zinc-based beauty line matrix; the beauty treatment line prepared by the preparation method can be controllably degraded and absorbed in a human body, does not need to be taken out after a secondary operation, and is convenient to use and wide in application range.
Description
Technical Field
The application relates to the technical field of medical cosmetology, in particular to a zinc-based cosmetic line with controllable degradation and a preparation method thereof.
Background
With the improvement of living standard, people pay more and more attention to the external image of the people, and the problems of skin looseness, tissue sagging, wrinkles and the like are paid more and more attention. With the rapid development of the cosmetic industry, the demand of cosmetic lines is increasing. The beauty thread developed in recent years has effects of lifting a tissue, filling a depressed tissue, reducing wrinkles, adjusting a facial contour, and the like after being embedded in a body surface tissue.
After the absorbable beauty line achieves the beauty effect in tissues, the absorbable beauty line can disappear through biodegradation, and secondary operation trauma can be avoided, so that the absorbable beauty line is favored by consumers. At present, the common absorbable cosmetic thread materials on the market mainly comprise: catgut, PGA/PGLA braided suture, PLA thread, PDO thread, PPDO thread, etc. The cosmetic thread material has the problems of poor mechanical property, low glass transition temperature, high requirement on storage and transportation conditions and the like, and can be embrittled when the temperature is slightly high in the storage and transportation process. In addition, the beauty line has certain rejection and inflammatory reaction after being implanted into tissues.
Zinc is one of trace elements essential for human life, and has the main functions of participating in nucleic acid metabolism and protein synthesis, and also participating in metabolism of sugar, lipid, vitamin A, etc. Zinc has a very close relationship with the growth and development, metabolism, immune function and the like of human bodies. In the related technology, documents report that zinc has good anti-inflammatory performance and collagen production promoting effect as a novel biomedical material, but the zinc-based material reported at present has in vitro cytotoxicity which is mainly caused by overhigh local concentration of zinc ions generated during initial degradation, and the in vitro cytotoxicity reaches 2-4 levels, thus not meeting the clinical use requirements.
Disclosure of Invention
In order to obtain the zinc-based cosmetic line with controllable degradation rate, controllable zinc ion release amount and controllable degradation meeting clinical requirements, the application provides the zinc-based cosmetic line with controllable degradation and a preparation method thereof.
In a first aspect, the application provides a zinc-based beauty line with controllable degradation, which adopts the following technical scheme:
a zinc-based beauty treatment line with controllable degradation consists of a zinc-based beauty treatment line substrate and an inorganic magnesium phosphate coating;
the zinc-based cosmetic line substrate is processed by zinc materials;
the inorganic magnesium phosphate coating is obtained by carrying out in-situ modification on a zinc-based cosmetic wire substrate by using magnesium salts and phosphates under an acidic condition.
By adopting the technical scheme, the zinc-based beauty line is manufactured by processing zinc materials, the zinc is one of trace elements necessary for maintaining human life, the main functions in human body are nucleic acid metabolism and protein synthesis, and metabolism of sugar, lipid, vitamin A and the like, and the zinc has a very close relation with growth, development, metabolism, immune function and the like of the human body; the corrosion rate of zinc is moderate, and the zinc generally tends to be fast first and slow later; by modifying the zinc-based beauty line in situ, the degradation rate and the release amount of zinc ions of the zinc-based beauty line can be effectively controlled, and the low-concentration zinc can improve the activity of cells, promote the proliferation and differentiation of the cells and has good biological safety.
Preferably, the zinc material is a pure zinc ingot or a zinc alloy.
By adopting the technical scheme, the zinc-based cosmetic wire substrate is prepared by selecting the pure zinc ingot or the zinc alloy as the raw material, and has the advantages of excellent mechanical property, high temperature resistance, low requirement on storage and transportation conditions and the like.
Preferably, the zinc alloy is a mixture prepared by adding one or more of magnesium, copper, silver, calcium or iron, wherein zinc is used as a base material, the mass percent of the zinc content is controlled to be not less than 95%.
By adopting the technical scheme, magnesium is a necessary mineral element for a human body, and is almost involved in all metabolic processes of the human body, including metabolism of protein, carbohydrate and fat, stability of nucleic acid structure is maintained, synthesis of protein is involved, body temperature and emotion are regulated, ion transport, generation and transmission of nerve impulse, muscle contraction, utilization of vitamin B group, vitamin C and vitamin E and the like;
copper is an indispensable micronutrient for human health, and has important effects on the development and function of blood, central nervous system and immune system, hair, skin and skeletal tissue, and internal organs such as brain, liver and heart;
silver is one of trace elements in human tissues, is harmless to human bodies, plays an antibacterial role along with the slow release of silver ions, has an active defense function on bacteria, further inhibits the invasion of the bacteria to skin, promotes the healing of skin wounds and increases the repair function of damaged cells;
calcium is the most abundant inorganic salt component in the human body, and Ca is useful for the human body in muscles, nerves, body fluids and bones2+The combined protein, calcium, is the main inorganic component of human bone and tooth, is also an essential element for nerve transmission, muscle contraction, blood coagulation, hormone release, milk secretion and the like, and participates in human metabolism;
iron is an essential trace element in human body content and participates in oxygen transportation and storage, and hemoglobin in erythrocytes is a carrier for transporting oxygen; iron is a constituent of hemoglobin, and can promote development, increase resistance to diseases, regulate tissue respiration, prevent fatigue, form heme, prevent and treat anemia due to iron deficiency, and restore skin to good blood color;
the zinc-based beauty wire obtained by processing the zinc alloy prepared from the raw materials has excellent comprehensive performances such as mechanical property, high temperature resistance, corrosion resistance and the like, can not cause rejection and inflammation problems after being implanted into a body, and has high biological safety; after the cosmetic line is implanted into a body, the cosmetic line can be degraded and absorbed in the body, the degradation period is controllable, and the cosmetic line is not required to be taken out again.
Preferably, the magnesium salt is magnesium sulfate or magnesium chloride; the phosphate is one or more of sodium phosphate, potassium phosphate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, sodium dihydrogen phosphate or potassium dihydrogen phosphate.
By adopting the technical scheme, magnesium salt and phosphate are used for carrying out in-situ modification on the zinc-based cosmetic thread substrate under an acidic condition to obtain a magnesium phosphate coating; on one hand, the degradation of the zinc-based beauty treatment line can be effectively controlled, and the high in vitro cytotoxicity caused by the over-high local concentration of zinc ions is avoided; on the other hand, the magnesium phosphate coating can slowly release magnesium element and phosphorus element and is used as nutrition supplement.
In a second aspect, the application provides a preparation method of a zinc-based beauty treatment line with controllable degradation, which adopts the following technical scheme:
a preparation method of a zinc-based beauty treatment line with controllable degradation specifically comprises the following steps:
s1 preparation of zinc-based beauty line substrate
Selecting a zinc material, turning a sheath, cutting the zinc material into a bar, performing heat preservation treatment on the bar, and performing hot extrusion on the bar into a thick wire with the diameter of 1-3 mm;
the thick wire is made into thin wire through a plurality of cold drawing processes, annealing is carried out once every four cold drawing processes, the made thin wire is placed in ethanol for ultrasonic cleaning, blow-drying and impression-pressing, and the zinc-based beauty line matrix with barbs is obtained;
s2 preparation of inorganic magnesium phosphate coating
Preparing a mixed salt solution with the mass concentration ratio of magnesium salt to phosphate substances of 1:1.2-1.8, and adjusting the pH value of the mixed salt solution by using hydroxide to obtain a coating modifying solution;
and (4) placing the zinc-based cosmetic thread base part prepared in the step (S1) in a coating modification solution, performing modification treatment, ultrasonically cleaning in ethanol, drying, vacuum packaging, and sterilizing to obtain the zinc-based cosmetic thread with the coating.
By adopting the technical scheme, the zinc-based cosmetic thread substrate is prepared by adopting the stamping process, and the unique indentation structure can improve the lifting effect of the cosmetic thread; the magnesium phosphate coating is modified on the zinc-based cosmetic thread substrate through in-situ reaction, the bonding strength of the obtained coating and the substrate is high, the release rate of zinc ions at the initial degradation stage of the substrate can be obviously reduced, the anti-inflammatory performance and the biocompatibility of the cosmetic thread are improved, and the generation of collagen can be stimulated. In addition, the purpose of controllable degradation is achieved by controlling the length of the modified coating and the thickness of the modified coating; in the initial degradation stage, the degradation speed of the unmodified section is higher, and the degradation speed of the modified section is lower; with the lapse of time, the degradation speed of the unmodified segment becomes slower, and the degradation speed of the modified segment becomes faster, so that the whole release amount and release rate of zinc ions can be effectively controlled, and the clinical use requirement is met; the preparation method is simple to operate and low in cost, and the obtained beauty line has excellent mechanical property, biocompatibility and anti-inflammatory property, controllable degradation speed, stable performance, high-temperature-resistant storage and transportation and good application prospect, and can stimulate the generation of collagen.
Preferably, the heat preservation temperature of the bar in the step S1 is 200-; the extrusion ratio of the bar is 100-300:1, and the extrusion temperature is 150-300 ℃.
Preferably, the heat preservation temperature of the bar in the step S1 is 220-; the extrusion ratio of the bar is 150-280:1, and the extrusion temperature is 220-300 ℃.
Preferably, the heat preservation temperature of the bar in the step S1 is 250 ℃, and the heat preservation time is 1.8 h; the extrusion ratio of the bars was 200:1 and the extrusion temperature was 250 ℃.
Preferably, the diameter of the filament in the step S1 is 0.2-0.6 mm; the annealing temperature after each four-step cold drawing is 180-230 ℃, and the annealing heat preservation time is 10-30 min.
Preferably, the diameter of the filament in the step S1 is 0.4 mm; the annealing temperature after each four-pass cold drawing is 200 ℃, and the annealing heat preservation time is 20 min.
By adopting the technical scheme, further research shows that when the parameters of the steps in the preparation method are in the range, the zinc-based beauty line has high mechanical strength, high temperature resistance and good corrosion resistance.
Preferably, the zinc-based beauty line matrix with barbs in the step S1 comprises a bidirectional barbed section and a non-barbed section;
the bidirectional barb section comprises a forward barb section and a reverse barb section, and the barb shapes and sizes, the arrangement modes and the arrangement intervals of the forward barb section and the reverse barb section are the same, and the directions are opposite; the length of the barb sections is 42-50mm, and the barb intervals are 2-5 mm;
the barbs in the bidirectional barb sections are axially arranged along the zinc-based beauty line matrix, the number of rows of barbs is 2, the shapes and sizes of the barbs are symmetrical along the axis of the zinc-based beauty line matrix, the two rows of barbs are staggered, the arrangement distance is 0.8-1.5mm, the barbs are parallelogram, the included angle between the barbs and the beauty line matrix is 25-40 degrees, and the beauty line matrix is 11-16cm long.
Preferably, the lengths of the barb sections of the zinc-based beauty line base body with barbs in the step S1 are all 48mm, the barb intervals are all 4mm, and the arrangement interval is 1 mm.
Preferably, in the step S1, the included angle between the barbs of the zinc-based beauty line matrix with barbs and the beauty line matrix is 30-35 degrees, and the length of the beauty line matrix is 13-16 cm.
Preferably, in the step S1, an included angle between the barbs of the zinc-based beauty line matrix with barbs and the beauty line matrix is 32 °, and the length of the beauty line matrix is 15 cm.
By adopting the technical scheme, the barb can play a good role in suturing and fixing, and can effectively prevent tissues from sliding, so that tissue-related ischemia is reduced, tissue extrusion is reduced, and tissue healing and scar recovery are accelerated; meanwhile, the operation time can be effectively shortened, and the operation efficiency is improved.
Preferably, the concentration of the hydroxide in the step S2 is 0.8 to 1.5mol/L, and the hydroxide is sodium hydroxide and potassium hydroxide; the pH value of the coating modifying liquid is 4.0-5.5.
Preferably, the concentration of the hydroxide in the step S2 is 1-1.2mol/L, and the hydroxide is sodium hydroxide and potassium hydroxide; the pH value of the coating modifying liquid is 4.0-5.0.
Preferably, the concentration of the hydroxide in the step S2 is 1mol/L, and the hydroxide is sodium hydroxide and potassium hydroxide; the pH of the coating modifying solution was 4.5.
Preferably, the modification treatment in step S2 specifically refers to: the modification temperature is 20-50 ℃, and the modification time is 3-72 h; the modified length of the coating is 70-90% of the total length of the zinc-based cosmetic line substrate; the thickness of the coating is 8-50 μm.
Preferably, the modification treatment in step S2 specifically refers to: the modification temperature is 25-40 ℃, and the modification time is 10-60 h; the modified length of the coating is 75-85% of the total length of the zinc-based cosmetic line substrate; the thickness of the coating is 15-45 μm.
Preferably, the modification treatment in step S2 specifically refers to: the modification temperature is 32 ℃, and the modification time is 30 h; the modified length of the coating is 80% of the total length of the zinc-based cosmetic line substrate; the coating thickness was 30 μm.
By adopting the technical scheme, further research shows that when the parameters of the steps in the preparation method are in the range, the prepared zinc-based cosmetic line has good degradation rate controllability, a proper degradation period, a proper zinc ion release concentration and a good cosmetic line application effect.
In summary, the present application has the following beneficial effects:
1. the zinc-based beauty line matrix with the barbs is prepared by adopting a zinc material as a raw material through the steps of turning, cutting, extruding, drawing, impressing and the like, and the required zinc-based beauty line is obtained by carrying out in-situ modification on the zinc-based beauty line matrix through magnesium salt and phosphate under an acidic condition; the obtained beauty line has excellent mechanical property, good heat resistance and corrosion resistance, low requirement on storage and transportation conditions, and high-temperature resistance storage and transportation; the agnail section is arranged on the zinc-based cosmetic thread substrate, so that the operation efficiency can be effectively improved, the tissue sliding is prevented, the healing time is shortened, and the infection is reduced; the zinc-based beauty line also has good anti-inflammatory performance and the function of promoting the generation of collagen.
2. The preparation method is simple, the preparation conditions are mild, and the zinc-based cosmetic thread substrate is modified in situ under the acidic condition through the magnesium salt and the phosphate to obtain the zinc-based cosmetic thread containing the coating; the cosmetic thread has good biocompatibility, and can achieve good cosmetic effects of lifting tissues, filling sunken tissues, reducing wrinkles, adjusting facial contours and the like after being implanted into tissues; the utility model provides a beauty line can not produce rejection and inflammation problem to the human body in the use, and it reaches cosmetic effect back in the tissue, can be controllable in human degradation absorption, need not the secondary operation and takes out, convenient to use, and application scope is wide.
Drawings
FIG. 1 is a schematic structural view of a zinc-based beauty line substrate with barbs in the present application;
FIG. 2 is a top view of FIG. 1;
FIG. 3 is an enlarged view of portion A of FIG. 1;
FIG. 4 is an enlarged view of portion B of FIG. 2;
FIG. 5 is a zinc-based cosmetic thread containing a coating in the present application;
in the figure: 1. a zinc-based cosmetic thread substrate; 12. a barb; 13. a forward barb section; 14. a reverse barb section; 15. an inorganic magnesium phosphate coating;
fig. 6 is a graph comparing the coating section (a) and the non-coating section (B) of the controlled degradation zinc-based beauty line prepared in example 1 of the present application.
Detailed Description
The present application is described in further detail below with reference to the accompanying examples, with reference to fig. 1-6.
Example 1
The application provides a zinc-based beauty treatment line of controllable degradation adopts following technical scheme:
a zinc-based beauty treatment line with controllable degradation consists of a zinc-based beauty treatment line substrate 1 and an inorganic magnesium phosphate coating 15;
wherein the zinc-based cosmetic line matrix 1 is processed by pure zinc ingots;
the inorganic magnesium phosphate coating 15 is obtained by carrying out in-situ modification on a zinc-based cosmetic wire substrate 1 by using magnesium salts and phosphates under an acidic condition;
magnesium salt is magnesium sulfate;
the phosphate is sodium dihydrogen phosphate.
The application also provides a preparation method of the zinc-based beauty treatment line with controllable degradation, which specifically comprises the following steps:
s1 preparation of zinc-based cosmetic thread substrate 1
Selecting a pure zinc ingot to turn a sheath and cut the pure zinc ingot into a bar, performing heat preservation treatment on the bar, then performing hot extrusion on the bar into a thick wire with the diameter of 1mm, controlling the heat preservation temperature of the bar to be 250 ℃, the heat preservation time to be 2 hours, and controlling the extrusion ratio of the bar to be 200:1 and the extrusion temperature to be 250 ℃;
processing the thick filaments into filaments with the diameter of 0.57mm through a plurality of cold drawing processes, annealing once every four cold drawing processes, controlling the annealing temperature to be 190 ℃, annealing and preserving heat for 20min, placing the obtained filaments in ethanol, ultrasonically cleaning, drying and impressing to obtain a zinc-based beauty line substrate 1 with barbs 12 and the length of 16 cm;
the zinc-based cosmetic line matrix 1 comprises a bidirectional barb section and a barb-free section; the bidirectional barb section comprises a forward barb section 13 and a reverse barb section 14, and barbs 12 of the forward barb section 13 and the reverse barb section 14 have the same shape, size, arrangement mode and arrangement interval and opposite directions; the length of each barb segment is 48mm, and the intervals of the barbs 12 are 4 mm; barbs 12 in the bidirectional barb section are axially arranged along a zinc-based beauty line base body 1, the rows of the barbs 12 are 2, the shapes and the sizes of the barbs 12 are symmetrical along the axis of the zinc-based beauty line base body 1, the two rows of the barbs 12 are staggered, the arrangement distance is 1mm, the barbs 12 are parallelogram, and the included angle between the barbs 12 and the beauty line base body 1 is 35 degrees;
s2 preparation of inorganic magnesium phosphate coating 15
Preparing 100mL of mixed salt solution with the mass concentration ratio of magnesium sulfate to sodium dihydrogen phosphate being 1:1.5, and adjusting the pH value of the mixed salt solution to 4.0 by using 1mol/L potassium hydroxide to obtain coating modification liquid;
placing 70% of the total length of the zinc-based cosmetic thread substrate 1 prepared in the step S1 in a coating modification solution, performing modification treatment at 37 deg.C for 5h, ultrasonically cleaning in ethanol, repeating for 3 times, drying, vacuum packaging, and using60Co- ϒ ray radiation sterilization, the zinc base beauty line containing coating with thickness of 15 μm is obtained.
Example 2
The application provides a zinc-based beauty treatment line of controllable degradation adopts following technical scheme:
a zinc-based beauty treatment line with controllable degradation consists of a zinc-based beauty treatment line substrate 1 and an inorganic magnesium phosphate coating 15;
wherein the zinc-based cosmetic line substrate 1 is processed by zinc alloy;
the zinc alloy is obtained by mixing 99.95 mass percent of zinc as a base material and 0.05 mass percent of magnesium.
The inorganic magnesium phosphate coating 15 is obtained by carrying out in-situ modification on a zinc-based cosmetic wire substrate 1 by using magnesium salts and phosphates under an acidic condition;
magnesium salt is magnesium sulfate;
the phosphate is sodium dihydrogen phosphate.
The application also provides a preparation method of the zinc-based beauty treatment line with controllable degradation, which specifically comprises the following steps:
s1 preparation of zinc-based cosmetic thread substrate 1
Selecting zinc alloy to turn a sheath and cut the zinc alloy into a bar, carrying out heat preservation treatment on the bar, then carrying out hot extrusion on the bar into a thick wire with the diameter of 1mm, controlling the heat preservation temperature of the bar to be 300 ℃, the heat preservation time to be 1.5h, the extrusion ratio of the bar to be 180:1 and the extrusion temperature to be 230 ℃;
processing the thick wire into a thin wire with the diameter of 0.45mm through a plurality of cold drawing processes, annealing once every four cold drawing processes, controlling the annealing temperature to be 210 ℃, annealing and preserving heat for 20min, placing the prepared thin wire in ethanol, ultrasonically cleaning, drying, and impressing to obtain a zinc-based beauty thread substrate 1 with barbs 12 and the length of 13 cm;
the zinc-based cosmetic line matrix 1 comprises a bidirectional barb section and a barb-free section; the bidirectional barb section comprises a forward barb section 13 and a reverse barb section 14, and barbs 12 of the forward barb section 13 and the reverse barb section 14 have the same shape, size, arrangement mode and arrangement interval and opposite directions; the length of each barb segment is 45mm, and the intervals of the barbs 12 are 3.5 mm; barbs 12 in the two-way barb section are axially arranged along the zinc-based beauty line base body 1, the rows of the barbs 12 are 2, the shapes and the sizes of the barbs 12 are symmetrical along the axis of the zinc-based beauty line base body 1, the two rows of barbs 12 are staggered, the arrangement distance is 1.2mm, the barbs 12 are parallelogram, and the included angle between the barbs 12 and the beauty line base body 1 is 35 degrees;
s2 preparation of inorganic magnesium phosphate coating 15
Preparing magnesium sulfate: 100mL of mixed salt solution with the mass concentration ratio of sodium dihydrogen phosphate substances being 1:1.5, and adjusting the pH value of the mixed salt solution to 4.5 by using 1mol/L sodium hydroxide to obtain coating modification solution;
placing 80% of the total length of the zinc-based cosmetic thread substrate 1 prepared in the step S1 in a coating modification solution, performing modification treatment at 25 deg.C for 72h, ultrasonically cleaning in ethanol, repeating for 3 times, drying, vacuum packaging, and using60Co- ϒ ray irradiation sterilization to obtain zinc-based cosmetic line with coating thickness of 42 μm.
Example 3
The application provides a zinc-based beauty line with controllable degradation, which adopts the following technical scheme:
a zinc-based beauty treatment line with controllable degradation consists of a zinc-based beauty treatment line substrate 1 and an inorganic magnesium phosphate coating 15;
wherein the zinc-based cosmetic line matrix 1 is processed by pure zinc ingots;
the inorganic magnesium phosphate coating 15 is obtained by carrying out in-situ modification on a zinc-based cosmetic wire substrate 1 by using magnesium salts and phosphates under an acidic condition;
the magnesium salt is magnesium chloride;
the phosphate is disodium hydrogen phosphate.
The application also provides a preparation method of the zinc-based beauty treatment line with controllable degradation, which specifically comprises the following steps:
s1 preparation of zinc-based cosmetic thread substrate 1
Selecting a pure zinc ingot to turn a sheath and cut the pure zinc ingot into a bar, carrying out heat preservation treatment on the bar, then carrying out hot extrusion on the bar into a thick wire with the diameter of 1mm, controlling the heat preservation temperature of the bar at 280 ℃, the heat preservation time at 1.5h, the extrusion ratio of the bar at 100:1 and the extrusion temperature at 280 ℃;
processing the thick wire into a thin wire with the diameter of 0.4mm through a plurality of cold drawing processes, annealing once every four cold drawing processes, controlling the annealing temperature to be 180 ℃, annealing and preserving heat for 30min, placing the prepared thin wire in ethanol, ultrasonically cleaning, drying and impressing to obtain a zinc-based beauty thread substrate 1 with barbs 12 and the length of 13 cm;
the zinc-based cosmetic line matrix 1 comprises a bidirectional barb section and a barb-free section; the bidirectional barb section comprises a forward barb section 13 and a reverse barb section 14, and barbs 12 of the forward barb section 13 and the reverse barb section 14 have the same shape, size, arrangement mode and arrangement interval and opposite directions; the length of each barb section is 48mm, and the intervals of the barbs 12 are 4 mm; barbs 12 in the bidirectional barb section are axially arranged along a zinc-based beauty line base body 1, the rows of the barbs 12 are 2, the shapes and the sizes of the barbs 12 are symmetrical along the axis of the zinc-based beauty line base body 1, the two rows of the barbs 12 are staggered, the arrangement distance is 1mm, the barbs 12 are parallelogram, and the included angle between the barbs 12 and the beauty line base body 1 is 25 degrees;
s2 preparation of inorganic magnesium phosphate coating 15
Preparing 100mL of mixed salt solution with the mass concentration ratio of magnesium chloride to disodium hydrogen phosphate of 1:1.5, and adjusting the pH of the mixed salt solution to 5.0 by using 1mol/L sodium hydroxide to obtain coating modification liquid;
placing 90% of the total length of the zinc-based cosmetic thread substrate 1 prepared in the step S1 in a coating modification solution, performing modification treatment at 37 deg.C for 5h, ultrasonically cleaning in ethanol, repeating for 3 times, drying, vacuum packaging, and using60Co- ϒ ray irradiation sterilization to obtain zinc-based cosmetic line containing coating with thickness of 15 μm.
Example 4
The application provides a zinc-based beauty treatment line of controllable degradation adopts following technical scheme:
a zinc-based beauty treatment line with controllable degradation consists of a zinc-based beauty treatment line substrate 1 and an inorganic magnesium phosphate coating 15;
wherein the zinc-based cosmetic line substrate 1 is processed by zinc alloy;
the zinc alloy is obtained by mixing 95 mass percent of zinc as a base material, 2.2 mass percent of magnesium, 0.8 mass percent of copper, 0.04 mass percent of silver, 1.3 mass percent of calcium and 0.66 mass percent of iron.
The inorganic magnesium phosphate coating 15 is obtained by carrying out in-situ modification on a zinc-based cosmetic wire substrate 1 by using magnesium salts and phosphates under an acidic condition;
the magnesium salt is magnesium chloride;
the phosphate is sodium phosphate.
The application also provides a preparation method of the zinc-based beauty treatment line with controllable degradation, which specifically comprises the following steps:
s1 preparation of zinc-based cosmetic thread substrate 1
Selecting zinc alloy to turn a sheath and cut the zinc alloy into a bar, carrying out heat preservation treatment on the bar, then carrying out hot extrusion on the bar into a thick wire with the diameter of 1.5mm, controlling the heat preservation temperature of the bar to be 200 ℃, the heat preservation time to be 2.5h, the extrusion ratio of the bar to be 150:1 and the extrusion temperature to be 180 ℃;
processing the thick wire into a thin wire with the diameter of 0.2mm through a plurality of cold drawing processes, annealing once every four cold drawing processes, controlling the annealing temperature to be 180 ℃, annealing and preserving heat for 30min, placing the prepared thin wire in ethanol, ultrasonically cleaning, drying and impressing to obtain a zinc-based beauty thread substrate 1 with a barb 12 and the length of 12 cm;
the zinc-based cosmetic line matrix 1 comprises a bidirectional barb section and a barb-free section; the bidirectional barb section comprises a forward barb section 13 and a reverse barb section 14, and barbs 12 of the forward barb section 13 and the reverse barb section 14 have the same shape, size, arrangement mode and arrangement interval and opposite directions; the length of each barb segment is 42mm, and the intervals of the barbs 12 are 2 mm; barbs 12 in the two-way barb section are axially arranged along the zinc-based beauty line base body 1, the rows of the barbs 12 are 2, the shapes and the sizes of the barbs 12 are symmetrical along the axis of the zinc-based beauty line base body 1, the two rows of barbs 12 are staggered, the arrangement distance is 0.8mm, the barbs 12 are parallelogram, and the included angle between the barbs 12 and the beauty line base body 1 is 28 degrees;
s2 preparation of inorganic magnesium phosphate coating 15
Preparing 100mL of mixed salt solution with the mass concentration ratio of magnesium chloride to sodium phosphate of 1:1.2, and adjusting the pH value of the mixed salt solution to 4.0 by using 0.8mol/L sodium hydroxide to obtain coating modification solution;
75% of the total length of the zinc-based cosmetic thread substrate 1 prepared in the step S1 is placed in the coating modification liquid for modification treatment and controlThe sexual temperature is 20 deg.C, the modification time is 72h, then ultrasonic cleaning in ethanol, repeating for 3 times, drying, vacuum packaging, and using60Co- ϒ ray irradiation sterilization to obtain zinc-based cosmetic line containing coating with thickness of 45 μm.
Example 5
The application provides a zinc-based beauty line with controllable degradation, which adopts the following technical scheme:
a zinc-based beauty treatment line with controllable degradation consists of a zinc-based beauty treatment line substrate 1 and an inorganic magnesium phosphate coating 15;
wherein the zinc-based cosmetic line substrate 1 is processed by zinc alloy;
the zinc alloy is obtained by mixing 98.5 mass percent of zinc as a base material, 0.8 mass percent of magnesium and 0.7 mass percent of calcium.
The inorganic magnesium phosphate coating 15 is obtained by carrying out in-situ modification on a zinc-based beauty line substrate 1 by magnesium salt and phosphate under an acidic condition;
the magnesium salt is magnesium chloride;
the phosphate is dipotassium hydrogen phosphate.
The application also provides a preparation method of the zinc-based beauty line with controllable degradation, which specifically comprises the following steps:
s1 preparation of zinc-based cosmetic thread substrate 1
Selecting zinc alloy to turn a sheath and cut the zinc alloy into a bar, carrying out heat preservation treatment on the bar, then carrying out hot extrusion on the bar into a thick wire with the diameter of 2mm, controlling the heat preservation temperature of the bar to be 220 ℃, the heat preservation time to be 2.2h, the extrusion ratio of the bar to be 220:1 and the extrusion temperature to be 240 ℃;
processing the thick wire into a thin wire with the diameter of 0.3mm through a plurality of cold drawing processes, annealing once every four cold drawing processes, controlling the annealing temperature to be 190 ℃, carrying out annealing heat preservation for 25min, placing the prepared thin wire in ethanol, carrying out ultrasonic cleaning, drying, and stamping to obtain a zinc-based beauty thread substrate 1 with barbs 12 and the length of 14 cm;
the zinc-based cosmetic line matrix 1 comprises a bidirectional barb section and a barb-free section; the bidirectional barb section comprises a forward barb section 13 and a reverse barb section 14, and barbs 12 of the forward barb section 13 and the reverse barb section 14 have the same shape, size, arrangement mode and arrangement interval and opposite directions; the length of each barb segment is 44mm, and the intervals of the barbs 12 are 3 mm; barbs 12 in the bidirectional barb sections are axially arranged along the zinc-based beauty line matrix 1, the number of the rows of the barbs 12 is 2, the shapes and the sizes of the barbs 12 are symmetrical along the axis of the zinc-based beauty line matrix 1, the two rows of barbs 12 are staggered, the arrangement distance is 1.2mm, the barbs 12 are parallelogram, and the included angle between the barbs 12 and the beauty line matrix 1 is 32 degrees;
s2 preparation of inorganic magnesium phosphate coating 15
Preparing 100mL of mixed salt solution with the mass concentration ratio of magnesium chloride to dipotassium hydrogen phosphate being 1:1.4, and adjusting the pH of the mixed salt solution to 4.8 by using 1.2mol/L of potassium hydroxide to obtain coating modification liquid;
placing 85% of the total length of the zinc-based cosmetic thread substrate 1 prepared in the step S1 in a coating modification solution, performing modification treatment at 40 deg.C for 15h, ultrasonically cleaning in ethanol, repeating for 3 times, drying, vacuum packaging, and using60Co- ϒ ray irradiation was used for sterilization to obtain a zinc-based cosmetic line containing a coating layer with a thickness of 37 μm.
Example 6
The application provides a zinc-based beauty treatment line of controllable degradation adopts following technical scheme:
a zinc-based beauty treatment line with controllable degradation consists of a zinc-based beauty treatment line substrate 1 and an inorganic magnesium phosphate coating 15;
wherein the zinc-based cosmetic line substrate 1 is processed by zinc alloy;
the zinc alloy is obtained by mixing 99.2 mass percent of zinc as a base material and 0.8 mass percent of iron.
The inorganic magnesium phosphate coating 15 is obtained by carrying out in-situ modification on a zinc-based cosmetic wire substrate 1 by using magnesium salts and phosphates under an acidic condition;
magnesium salt is magnesium sulfate;
the phosphate is potassium phosphate.
The application also provides a preparation method of the zinc-based beauty treatment line with controllable degradation, which specifically comprises the following steps:
s1 preparation of zinc-based cosmetic thread substrate 1
Selecting zinc alloy to turn a sheath and cut the zinc alloy into a bar, performing heat preservation treatment on the bar, then performing hot extrusion on the bar into a thick wire with the diameter of 3mm, controlling the heat preservation temperature of the bar to be 270 ℃, the heat preservation time to be 1.7h, the extrusion ratio of the bar to be 300:1 and the extrusion temperature to be 300 ℃;
processing the thick wire into a thin wire with the diameter of 0.6mm through a plurality of cold drawing processes, annealing once every four cold drawing processes, controlling the annealing temperature at 230 ℃, annealing and preserving heat for 10min, placing the prepared thin wire in ethanol, ultrasonically cleaning, drying and impressing to obtain a zinc-based beauty thread substrate 1 with a barb 12 and the length of 15 cm;
the zinc-based cosmetic line matrix 1 comprises a bidirectional barb section and a barb-free section; the bidirectional barb section comprises a forward barb section 13 and a reverse barb section 14, and the barbs 12 of the forward barb section 13 and the reverse barb section 14 have the same shape, size, arrangement mode and arrangement interval and opposite directions; the length of each barb segment is 50mm, and the barb intervals are 5 mm; barbs 12 in the two-way barb section are axially arranged along the zinc-based beauty line base body 1, the rows of the barbs 12 are 2, the shapes and the sizes of the barbs 12 are symmetrical along the axis of the zinc-based beauty line base body 1, the two rows of barbs 12 are staggered, the arrangement distance is 1.5mm, the barbs 12 are parallelogram, and the included angle between the barbs 12 and the beauty line base body 1 is 40 degrees;
s2 preparation of inorganic magnesium phosphate coating 15
Preparing 100mL of mixed salt solution with the mass concentration ratio of magnesium salt to phosphate substance of 1:1.8, and adjusting the pH of the mixed salt solution to 5.5 by using potassium hydroxide with the concentration of 1.5mol/L to obtain coating modification solution;
placing 90% of the total length of the zinc-based cosmetic thread substrate 1 prepared in the step S1 in a coating modification solution, performing modification treatment at 50 deg.C for 3h, ultrasonically cleaning in ethanol, repeating for 3 times, drying, vacuum packaging, and using60Co- ϒ ray irradiation sterilization to obtain zinc-based cosmetic line with 16 μm thick coating.
Comparative example 1
The same preparation method as that of example 1 was used except that 60% of the total length of the prepared zinc-based cosmetic thread substrate 1 was placed in the coating layer modifying solution to be modified in step S2 of comparative example 1.
Comparative example 2
The same preparation method as that of example 1 was used except that 100% of the total length of the prepared zinc-based cosmetic thread substrate 1 was placed in the coating layer modifying solution to be modified in step S2 of comparative example 1.
Comparative example 3
By the same production method as in step S1 of example 1, only the zinc-based cosmetic thread substrate was produced without modification.
Firstly, testing mechanical properties
The beauty treatment lines prepared in examples 1 to 6 and comparative examples 1 to 3 of the present application were subjected to a tensile test at room temperature, at a tensile rate of 200mm/min and a gauge length of 100 mm; the results of the tensile test are shown in table 1:
TABLE 1 mechanical Property test results
From table 1 above, it can be seen that: the cosmetic thread prepared in examples 1 to 6 and comparative examples 1 to 3 of the present application is excellent in mechanical properties, and it can be seen from comparative example 1 and comparative examples 1 to 3 that: the preparation of the inorganic magnesium phosphate coating has almost no influence on the mechanical property of the beauty treatment line.
Second, in vitro degradation experiment
The zinc-based beauty treatment lines prepared in examples 1 to 6 and comparative examples 1 to 3 of the present application were respectively left to stand in 100mL of PBS buffer (pH 7.40) and soaked at 37 ℃ for 5 days, and the change of the pH of PBS within 5 days of soaking of the zinc-based beauty treatment lines prepared in examples 1 to 6 and comparative examples 1 to 3 was recorded, and the results were shown in table 2:
TABLE 2 pH Change of PBS
As can be seen from table 2 above: the change of the pH value of the PBS solution corresponding to the zinc-based beauty treatment line prepared in the embodiment 1-6 is obviously smaller than that of the coating modified by 60% in the comparative example 1 and that of the unmodified zinc-based beauty treatment line substrate in the comparative example 3, which shows that the modified zinc-based beauty treatment line is relatively slowly degraded in the initial stage and correspondingly the release amount of zinc ions is relatively reduced; the coating of the comparative example 2 is modified by 100 percent, and is hardly degraded in the early stage and has no zinc ion release amount; in conclusion, the zinc-based cosmetic line is subjected to coating modification, and when the modification area is 70-90%, the degradation rate and the release amount of zinc ions are optimal.
Third, biocompatibility test
The zinc-based beauty treatment lines prepared in examples 1-6 and comparative examples 1-3 of the present application were added to a well plate according to a leaching ratio (sample mass: leaching medium) of 0.2g/mL to be leached, and the mixture was placed at 37 ℃ and 95% relative humidity and 5% CO2Obtaining corresponding leaching liquor in an incubator for 24 hours; the leaching medium is H-DMEM cell culture medium.
L929 cells were recovered, passaged, suspended in H-DMEM cell culture medium at 1.0X 105Inoculating the cells with the density of one/mL on a 96-pore plate culture plate, sucking out the original culture medium after culturing for 24 hours, adding the cell culture medium into a control group, and adding the leaching liquor into an experimental group; placing at 37 deg.C and 5% CO2After 24h of culture in an incubator, the cells were taken out and tested for activity, and the results are shown in table 3:
TABLE 3 changes in the Activity of L929 cells
As can be seen from table 3 above: after the L929 cells are cultured in the leaching liquor in the embodiment 1-6 for one day, the cell activity is still 97.0% or more, the cell activity after the leaching liquor in the comparative example 1 is cultured is reduced to 94.2%, the cell activity after the leaching liquor in the comparative example 3 is only 81.7%, and the comparative example 1 and the comparative example 3 show that the zinc-based beauty treatment line is modified, the in vitro cytotoxicity can be obviously reduced, and the biocompatibility of the modified zinc-based beauty treatment line is good.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (10)
1. A zinc-based beauty treatment line with controllable degradation is characterized by consisting of a zinc-based beauty treatment line substrate (1) and an inorganic magnesium phosphate coating (15);
the zinc-based beauty line matrix (1) is processed by zinc materials;
the inorganic magnesium phosphate coating (15) is obtained by modifying a zinc-based beauty treatment wire substrate (1) in situ by magnesium salt and phosphate under an acidic condition.
2. The zinc-based cosmetic line of claim 1, wherein the zinc material is a pure zinc ingot or a zinc alloy.
3. The zinc-based beauty line of controlled degradation according to claim 2, characterized in that the zinc alloy is a mixture made by adding one or more of magnesium, copper, silver, calcium or iron, with zinc as a base material, and controlling the zinc content not less than 95% by mass.
4. The controlled degradation zinc-based cosmetic thread of claim 1, wherein the magnesium salt is magnesium sulfate or magnesium chloride; the phosphate is one or more of sodium phosphate, potassium phosphate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, sodium dihydrogen phosphate or potassium dihydrogen phosphate.
5. A method for preparing a controlled degradation zinc-based cosmetic thread according to any one of claims 1 to 4, comprising the following steps:
s1 preparation of zinc-based beauty line substrate (1)
Selecting a zinc material, turning a sheath, cutting the zinc material into a bar, performing heat preservation treatment on the bar, and performing hot extrusion on the bar into a thick wire with the diameter of 1-3 mm;
the thick silk is made into thin silk through a plurality of cold drawing processes, annealing is carried out once every four cold drawing processes, the made thin silk is placed in ethanol for ultrasonic cleaning, blow-drying and impression-pressing, and the zinc-based beauty thread substrate (1) with barbs (12) is obtained;
s2 preparation of inorganic magnesium phosphate coating (15)
Preparing a mixed salt solution with the mass concentration ratio of magnesium salt to phosphate substances of 1:1.2-1.8, and adjusting the pH value of the mixed salt solution by using hydroxide to obtain a coating modifying solution;
and (3) placing part of the zinc-based beauty thread substrate (1) prepared in the step (S1) in a coating modification solution, carrying out modification treatment, then carrying out ultrasonic cleaning in ethanol, drying, vacuum packaging and sterilizing to obtain the zinc-based beauty thread containing the coating.
6. The method for preparing the zinc-based beauty line with controllable degradation according to claim 5, wherein the heat preservation temperature of the bar in the step S1 is 200-300 ℃, and the heat preservation time is 1.5-2.5 h; the extrusion ratio of the bar is 100-300:1, and the extrusion temperature is 150-300 ℃.
7. The method of claim 5, wherein the filament diameter of step S1 is 0.2-0.6 mm; the annealing temperature after each four-step cold drawing is 180-230 ℃, and the annealing heat preservation time is 10-30 min.
8. The method for preparing zinc-based beauty line with controllable degradation according to claim 5, characterized in that, the zinc-based beauty line base body (1) with barbs (12) in the step S1 comprises a bidirectional barbed section and a non-barbed section;
the bidirectional barb section comprises a forward barb section (13) and a reverse barb section (14), and the shapes, sizes, arrangement modes and arrangement intervals of barbs (12) of the forward barb section (13) and the reverse barb section (14) are the same, and the directions are opposite; the length of the barb sections is 42-50mm, and the intervals of the barbs (12) are 2-5 mm;
barbs (12) in the bidirectional barb section are axially arranged along the zinc-based cosmetic line base body (1), the rows of the barbs (12) are 2, the shapes and sizes of the barbs (12) are symmetrical along the axis of the zinc-based cosmetic line base body (1), the two rows of barbs (12) are staggered, the arrangement distance is 0.8-1.5mm, the barbs (12) are parallelogram, the included angle between the barbs (12) and the cosmetic line base body (1) is 25-40 degrees, and the length of the cosmetic line base body (1) is 11-16 cm.
9. The method for preparing controlled degradation zinc-based beauty line according to claim 5, characterized in that the hydroxide concentration in step S2 is 0.8-1.5mol/L, and the hydroxide is sodium hydroxide or potassium hydroxide; the pH value of the coating modifying liquid is 4.0-5.5.
10. The method for preparing the zinc-based beauty line with controllable degradation according to claim 5, wherein the modification treatment in the step S2 specifically comprises the following steps: the modification temperature is 20-50 ℃, and the modification time is 3-72 h; the modified length of the coating is 70-90% of the total length of the zinc-based cosmetic line substrate (1); the thickness of the coating is 8-50 μm.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115105647A (en) * | 2022-06-17 | 2022-09-27 | 北京诺康达医药科技股份有限公司 | Beauty treatment pulling line and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010057590A (en) * | 2008-09-02 | 2010-03-18 | Olympus Corp | Graft material and method of manufacturing the same |
| US20120271431A1 (en) * | 2009-09-04 | 2012-10-25 | Innotere Gmbh | Bioactively Coated Metal Implants and Methods for the Production Thereof |
| CN203663138U (en) * | 2013-09-27 | 2014-06-25 | 上海交通大学医学院附属第九人民医院 | Degradable anti-bacterial metal suture |
| CN110448728A (en) * | 2019-09-23 | 2019-11-15 | 上海交通大学 | The magnesium on medical Zr-based materials surface-phosphorus biocompatible coating and preparation and use |
| CN110585475A (en) * | 2019-09-18 | 2019-12-20 | 西南大学 | Light-operated antibacterial degradable zinc alloy suture material and preparation method thereof |
| CN110604632A (en) * | 2019-10-21 | 2019-12-24 | 中国人民解放军南部战区海军第一医院 | Biodegradable cosmetic pulling line and preparation method thereof |
| CN212261605U (en) * | 2020-06-29 | 2021-01-01 | 杭州爱普医疗器械股份有限公司 | Tree-shaped line |
-
2022
- 2022-02-16 CN CN202210143531.0A patent/CN114569801B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010057590A (en) * | 2008-09-02 | 2010-03-18 | Olympus Corp | Graft material and method of manufacturing the same |
| US20120271431A1 (en) * | 2009-09-04 | 2012-10-25 | Innotere Gmbh | Bioactively Coated Metal Implants and Methods for the Production Thereof |
| CN203663138U (en) * | 2013-09-27 | 2014-06-25 | 上海交通大学医学院附属第九人民医院 | Degradable anti-bacterial metal suture |
| CN110585475A (en) * | 2019-09-18 | 2019-12-20 | 西南大学 | Light-operated antibacterial degradable zinc alloy suture material and preparation method thereof |
| CN110448728A (en) * | 2019-09-23 | 2019-11-15 | 上海交通大学 | The magnesium on medical Zr-based materials surface-phosphorus biocompatible coating and preparation and use |
| CN110604632A (en) * | 2019-10-21 | 2019-12-24 | 中国人民解放军南部战区海军第一医院 | Biodegradable cosmetic pulling line and preparation method thereof |
| CN212261605U (en) * | 2020-06-29 | 2021-01-01 | 杭州爱普医疗器械股份有限公司 | Tree-shaped line |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115105647A (en) * | 2022-06-17 | 2022-09-27 | 北京诺康达医药科技股份有限公司 | Beauty treatment pulling line and preparation method thereof |
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