CN114569519A - Alcohol-free mouth wash and preparation method thereof - Google Patents

Alcohol-free mouth wash and preparation method thereof Download PDF

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CN114569519A
CN114569519A CN202210399596.1A CN202210399596A CN114569519A CN 114569519 A CN114569519 A CN 114569519A CN 202210399596 A CN202210399596 A CN 202210399596A CN 114569519 A CN114569519 A CN 114569519A
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blumea balsamifera
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stirring
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蔡雪飞
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Guizhou Huangguoshu Lishuang Pharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract

The invention belongs to the technical field of mouthwash, and particularly relates to alcohol-free mouthwash and a preparation method thereof; comprises the following raw materials: blumea balsamifera extract, xylitol, tween 80, 1, 2-propylene glycol, sodium benzoate, glycerol, peppermint oil and blumea balsamifera aromatic water; the preparation method comprises the following steps: 1) preparing the blumea balsamifera extract: extracting with ethanol to obtain herba Blumeae Balsamiferae extract; 2) dissolving xylitol in oleum Blumeae Balsamiferae aromatic water under stirring, adding tween 80, and stirring to obtain clear water solution; adding sodium benzoate into 1, 2-propylene glycol, stirring to dissolve, adding glycerol and oleum Menthae Dementholatum, stirring well to obtain alcoholic solution, mixing the aqueous solution and alcoholic solution, stirring well, adding herba Blumeae Balsamiferae extract, diluting with deionized water for extracting herba Blumeae Balsamiferae to constant volume of 60mL, and autoclaving to obtain collutory; and has fresh breath and remarkable bacteriostatic effect.

Description

Alcohol-free mouth wash and preparation method thereof
Technical Field
The invention belongs to the technical field of mouthwash, and particularly relates to alcohol-free mouthwash and a preparation method thereof.
Background
The oral health is one of the signs of human health and also one of the important signs of civilization in the modern society. Food scraps and the like remained in the oral cavity provide proper conditions for breeding of oral bacteria, so that a series of oral diseases such as dental pulp diseases, periodontal diseases and the like can be caused, in addition, oral odor also brings inconvenience to people, and brings more embarrassing experiences in work and life, and particularly, people who smoke for a long time have higher expectation and demand on breath freshening products. The mouthwash has better mobility and permeability compared with traditional oral care products, can clean any position in the oral cavity all-round in the oral cavity to more effective clean nursing to the oral cavity, in addition, contains antibacterial component in the mouthwash also can prevent the emergence of periodontal disease. At present, traditional oral care products represented by toothpaste and dental floss still occupy the market leading position, but with the improvement of living standard, the mouth wash which is deeply loved by consumers abroad is gradually popularized in China.
Most of the existing mouthwash products in the market have active ingredients mainly comprising chemical ingredients, and the mouthwashes taking natural active substances as main raw materials are rare, but most of the existing mouthwash products contain alcohol, and the effect of cleaning the oral cavity is achieved by adding other auxiliary materials and surfactants, so that the alcohol-containing mouthwashes are obviously not suitable for alcohol allergic people, drivers, overhead workers and other special groups; in addition, the existing mouthwash products mainly play a role in cleaning oral cavities, the quantity of the mouthwash with the antibacterial effect is limited, the market space is large, and the unique smell of the natural active substances also has unique advantages for refreshing breath.
Blumea balsamifera (L.). DC) is a herbaceous plant of Blumea genus of Compositae family, and is mainly distributed in provinces such as Guizhou, Yunnan, Guangxi, Guangdong, Fujian and Taiwan areas in China, wherein Blumea balsamifera produced in the Guizhou Ludian obtains a national geographical sign product. The blumea balsamifera mainly contains chemical components such as borneol, camphor, aromatic camphor, longifolene, caryophyllene oxide, myrcene and the like, and is pungent and bitter in taste. The blumea balsamifera root can be used as a medicine, and has remarkable pharmacological activities of analgesia, anti-inflammation, antibiosis, hemostasis and the like. The drug blumea balsamifera tablets collected in the 2020 edition of Chinese pharmacopoeia use blumea balsamifera as the only source. Blumea balsamifera is widely applied in the field of medicines and daily chemical products, is mainly used for treating scalds and infantile eczema, and products of daily chemical products taking blumea balsamifera as a raw material, such as toothpaste, soap and the like, are also reported in documents.
Disclosure of Invention
The invention aims to provide alcohol-free mouth wash and a preparation method thereof, and the alcohol-free mouth wash has fresh breath and obvious bacteriostatic effect.
In order to solve the technical problems, the invention adopts the following technical scheme:
an alcohol-free mouth wash comprises the following raw materials: blumea balsamifera extract, xylitol, tween 80, 1, 2-propylene glycol, sodium benzoate, glycerol, peppermint oil and blumea balsamifera aromatic water.
Further, the feed comprises the following raw materials in parts by weight: 16% of blumea balsamifera extract, 6.6% of xylitol, 800.42% of tween, 2.5% of 1, 2-propylene glycol, 0.06% of sodium benzoate, 4.3% of glycerol, 0.15% of peppermint oil and 69.97% of blumea balsamifera aromatic water.
A preparation method of alcohol-free mouthwash comprises the following steps:
1) preparing the blumea balsamifera extract: extracting with ethanol to obtain herba Blumeae Balsamiferae extract;
2) dissolving xylitol in oleum Blumeae Balsamiferae aromatic water under stirring, adding tween 80, and stirring to obtain clear water solution; adding sodium benzoate into 1, 2-propylene glycol, stirring, adding glycerol and oleum Menthae Dementholatum, stirring to obtain alcoholic solution, mixing the aqueous solution and alcoholic solution, stirring, adding herba Blumeae Balsamiferae extract, diluting with deionized water for extracting herba Blumeae Balsamiferae to 60mL, and autoclaving to obtain collutory.
Further, the preparation of the blumea balsamifera extract comprises the following specific steps: taking blumea balsamifera, and mixing the blumea balsamifera with the liquid-material ratio of 1: 8g/mL, using 75% ethanol, condensing and refluxing for 60min at the temperature of 60 ℃, filtering, combining the filtrates, and concentrating to 1/10 of the volume of the filtrate for later use.
Further, blumea balsamifera needs to be extracted repeatedly 2 times.
Compared with the prior art, the invention has at least one of the following beneficial effects:
the invention particularly relates to a preparation method of a bacteriostatic mouth wash which does not contain alcohol and takes blumea balsamifera extract as a main active ingredient, and has fresh breath and obvious bacteriostatic effect;
the invention aims to fully utilize the fragrance of natural blumea balsamifera and combine with antibacterial active ingredients of the blumea balsamifera to develop an alcohol-free mouth wash product, thereby providing a new idea for expanding the utilization of blumea balsamifera resources and developing a new product.
Drawings
FIG. 1 is a flow chart of the preparation process of the present invention.
Detailed Description
As shown in fig. 1, in order to make the objects, technical solutions and advantages of the present invention more clearly understood, the present invention will be further described in detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
An alcohol-free mouth wash comprises the following raw materials: blumea balsamifera extract, xylitol, tween 80, 1, 2-propylene glycol, sodium benzoate, glycerol, peppermint oil and blumea balsamifera aromatic water;
the invention particularly relates to a preparation method of a bacteriostatic mouth wash which does not contain alcohol and takes blumea balsamifera extract as a main active ingredient, and has fresh breath and obvious bacteriostatic effect;
the invention aims to fully utilize the fragrance of natural blumea balsamifera and combine with antibacterial active ingredients of the blumea balsamifera to develop an alcohol-free mouth wash product, thereby providing a new idea for expanding the utilization of blumea balsamifera resources and developing a new product.
Example 2
The alcohol-free mouth wash comprises the following raw materials in parts by weight: 16% of blumea balsamifera extract, 6.6% of xylitol, 800.42% of tween, 2.5% of 1, 2-propylene glycol, 0.06% of sodium benzoate, 4.3% of glycerol, 0.15% of peppermint oil and 69.97% of blumea balsamifera aromatic water;
the invention particularly relates to a preparation method of a bacteriostatic mouth wash which does not contain alcohol and takes blumea balsamifera extract as a main active ingredient, and has fresh breath and obvious bacteriostatic effect;
the invention aims to fully utilize the fragrance of natural blumea balsamifera and combine with antibacterial active ingredients of the blumea balsamifera to develop an alcohol-free mouth wash product, thereby providing a new idea for expanding the utilization of blumea balsamifera resources and developing a new product.
Example 3
A preparation method of alcohol-free mouthwash comprises the following steps:
1) preparing the blumea balsamifera extract: extracting with ethanol to obtain herba Blumeae Balsamiferae extract;
2) dissolving xylitol in oleum Blumeae Balsamiferae aromatic water under stirring, adding tween 80, and stirring to obtain clear water solution; adding sodium benzoate into 1, 2-propylene glycol, stirring, adding glycerol and oleum Menthae Dementholatum, stirring to obtain alcoholic solution, mixing the aqueous solution and alcoholic solution, stirring, adding herba Blumeae Balsamiferae extract, diluting with deionized water for extracting herba Blumeae Balsamiferae to 60mL, and autoclaving to obtain collutory.
The invention particularly relates to a preparation method of a bacteriostatic mouth wash which does not contain alcohol and takes blumea balsamifera extract as a main active ingredient, and has fresh breath and obvious bacteriostatic effect;
the invention aims to fully utilize the fragrance of natural blumea balsamifera and combine with antibacterial active ingredients of the blumea balsamifera to develop an alcohol-free mouth wash product, thereby providing a new idea for expanding the utilization of blumea balsamifera resources and developing a new product.
Example 4
A preparation method of alcohol-free mouthwash comprises the following steps:
1) preparing the blumea balsamifera extract: the method comprises the following specific steps:
the preparation method of the blumea balsamifera extract comprises the following specific steps: taking blumea balsamifera, and mixing the blumea balsamifera with the liquid-material ratio of 1: 8g/mL, condensing and refluxing for 60min at the temperature of 60 ℃ by using 75% ethanol, filtering, combining the filtrates, and concentrating to 1/10 of the volume of the filtrate for later use;
2) dissolving xylitol in oleum Blumeae Balsamiferae aromatic water under stirring, adding tween 80, and stirring to obtain clear water solution; adding sodium benzoate into 1, 2-propylene glycol, stirring, adding glycerol and oleum Menthae Dementholatum, stirring to obtain alcoholic solution, mixing the aqueous solution and alcoholic solution, stirring, adding herba Blumeae Balsamiferae extract, diluting with deionized water for extracting herba Blumeae Balsamiferae to 60mL, and autoclaving to obtain collutory.
The invention particularly relates to a preparation method of a bacteriostatic mouth wash which does not contain alcohol and takes blumea balsamifera extract as a main active ingredient, and has fresh breath and obvious bacteriostatic effect;
the invention aims to fully utilize the fragrance of natural blumea balsamifera herbs and develop a non-alcoholic mouthwash product by combining with antibacterial active ingredients of the blumea balsamifera, thereby providing a new idea for expanding the utilization of blumea balsamifera resources and developing a new product.
Example 5
A preparation method of alcohol-free mouthwash comprises the following steps:
1) preparing the blumea balsamifera extract: the method comprises the following specific steps:
the preparation method of the blumea balsamifera extract comprises the following specific steps: taking blumea balsamifera, and mixing the blumea balsamifera with the liquid-liquid ratio of 1: 8g/mL, condensing and refluxing for 60min at 60 ℃ by using 75% ethanol, repeatedly extracting for 2 times, filtering, combining filtrates, and concentrating to 1/10 of the volume of the filtrate for later use;
2) dissolving xylitol in oleum Blumeae Balsamiferae aromatic water under stirring, adding tween 80, and stirring to obtain clear water solution; adding sodium benzoate into 1, 2-propylene glycol, stirring, adding glycerol and oleum Menthae Dementholatum, stirring to obtain alcoholic solution, mixing the aqueous solution and alcoholic solution, stirring, adding herba Blumeae Balsamiferae extract, diluting with deionized water for extracting herba Blumeae Balsamiferae to 60mL, and autoclaving to obtain collutory.
The invention particularly relates to a preparation method of a bacteriostatic mouth wash which does not contain alcohol and takes blumea balsamifera extract as a main active ingredient, and has fresh breath and obvious bacteriostatic effect;
the invention aims to fully utilize the fragrance of natural blumea balsamifera herbs and develop a non-alcoholic mouthwash product by combining with antibacterial active ingredients of the blumea balsamifera, thereby providing a new idea for expanding the utilization of blumea balsamifera resources and developing a new product.
Example 6
The alcohol-free mouth wash comprises the following raw materials in parts by weight: 16% of blumea balsamifera extract, 6.6% of xylitol, 800.42% of tween, 2.5% of 1, 2-propylene glycol, 0.06% of sodium benzoate, 4.3% of glycerol, 0.15% of peppermint oil and 69.97% of blumea balsamifera aromatic water;
the preparation method comprises the following steps:
1) preparing the blumea balsamifera extract: the method comprises the following specific steps:
the preparation method of the blumea balsamifera extract comprises the following specific steps: weighing 2.5g of blumea balsamifera, and mixing the materials according to a material-liquid ratio of 1: 8, condensing and refluxing with 75% ethanol at 60 deg.C for 60min, filtering, extracting the residue for 2 times, filtering, mixing filtrates, and concentrating to 1/10;
2) dissolving xylitol in oleum Blumeae Balsamiferae aromatic water under stirring, adding tween 80, and stirring to obtain clear water solution; adding sodium benzoate into 1, 2-propylene glycol, stirring to dissolve, adding glycerol and oleum Menthae Dementholatum, stirring to obtain alcoholic solution, mixing the aqueous solution and alcoholic solution, stirring, adding herba Blumeae Balsamiferae extract, diluting with deionized water for extracting herba Blumeae Balsamiferae to constant volume of 60mL, and autoclaving to obtain collutory;
the invention particularly relates to a preparation method of a bacteriostatic mouth wash which does not contain alcohol and takes blumea balsamifera extract as a main active ingredient, and has fresh breath and obvious bacteriostatic effect;
the invention aims to fully utilize the fragrance of natural blumea balsamifera and combine with antibacterial active ingredients of the blumea balsamifera to develop an alcohol-free mouth wash product, thereby providing a new idea for expanding the utilization of blumea balsamifera resources and developing a new product.
Experimental analysis:
1. experiment of antibacterial activity of mouthwash
1.1 preparation of Blumeae Balsamiferae extract
Weighing 2.5g of blumea balsamifera, and mixing the materials according to a material-liquid ratio of 1: 8 extracting with 75% ethanol at 60 deg.C under reflux for 60min, filtering, extracting the residue for 2 times, filtering, mixing filtrates, and concentrating to 1/10.
1.2 verification of the bacteriostatic action of blumea balsamifera extract
Solid medium: weighing 1.0g of yeast extract powder, 2.0g of tryptone, 2.0g of sodium chloride and 2.5g of agar, placing the yeast extract powder, adding 200ml of distilled water into a conical flask, heating, stirring for dissolving, adjusting the pH value to about 7.3 by using NaOH with the concentration of 1mol/L, covering by using a silicon rubber plug, and wrapping the bottleneck of the conical flask by using newspaper.
Sterilizing, namely wrapping the culture dish prepared in advance with newspaper, and sterilizing the wrapped culture dish and the liquid culture medium in a high-pressure steam sterilizing pot at the temperature of 121 ℃ for 20 min.
And (4) pouring the plate, namely putting the sterilized instrument and the culture solution in an oven to dry the moisture. And (5) opening an ultraviolet lamp of the ultra-clean bench to sterilize the ultra-clean bench for about 15 min. After the sterilization of the super clean bench is finished, the instruments and the culture medium in the oven are moved into the super clean bench and are subjected to ultraviolet sterilization again for about 15 min. Wearing gloves, wiping the gloves and the super clean bench surface by alcohol cotton soaked by 75% alcohol, igniting an alcohol lamp after a culture medium is not scalded, starting to pour the plate, shaking the liquid culture medium uniformly when each plate is poured, and burning the mouth of the conical flask by using outer flame of the alcohol lamp to perform local sterilization.
And (3) inoculation, namely after the culture medium is completely solidified, dipping the preserved staphylococcus aureus by using an inoculating ring which is burned and cooled, carrying out streak inoculation on the surface of the solid culture medium, and after the inoculation is finished, putting the culture medium in a constant-temperature incubator at 37 ℃ for 24 hours.
The preparation of the bacterial suspension comprises weighing yeast extract powder 0.5g, tryptone 1.0g and sodium chloride 1.0g, placing in a conical flask, adding 100ml distilled water, heating, stirring for dissolving, adjusting pH to about 7.3 with 1mol/L NAOH, covering with a silicon rubber plug, and wrapping the bottle mouth with newspaper. And (3) sterilizing, after the liquid culture medium is cooled, lightly scraping staphylococcus aureus growing on the solid culture medium into the liquid culture medium by using an inoculating loop after burning and cooling in a super clean bench, and placing the liquid culture medium in a constant-temperature culture shaker at the temperature of 37 ℃ and the rotating speed of 180rpm for culturing for 24 hours.
Antibacterial experiment, preparing the solid culture medium, wrapping with blumea balsamifera extract, pipette tip, coater, culture dish, 2 layers of filter paper sheets with diameter of 6mm and beakers with newspaper paper, and sterilizing in a high-pressure steam sterilization kettle at 121 deg.C for 20 min. After the sterilization is finished, putting the sterilized instruments and the culture medium into an oven, and drying the water. Pouring the plate in a clean bench, standing for the culture medium to solidify, soaking 6 sterilized filter paper sheets with diameter of 6mm in 6 parts of blumea balsamifera extract with different concentrations of 125.00mg/ml, 62.50mg/ml, 31.25mg/ml, 15.63mg/ml, 7.81mg/ml and 3.91mg/m l, numbering No. 1, No. 2, No. 3, No. 4, No. 5 and No. 6 in sequence, taking one part of the filter paper sheets soaked with 75% ethanol as a blank control group, and soaking in the blumea balsamifera extract for 10 min. And transferring 60 mu l of bacterial suspension on a solid culture medium by using a liquid transfer gun, uniformly smearing the bacterial suspension by using a cooled spreader after firing, clamping and sticking the soaked filter paper piece on the solid culture medium coated with the bacterial suspension by using forceps, slightly pressing, and then putting in a constant-temperature incubator at 37 ℃ for culturing for 24 hours. And then measuring the diameter of the inhibition zone by adopting a cross method, and recording data.
1.3 evaluation of bacteriostatic Effect
TABLE 1 antibacterial experiment analysis table of extract
Figure BDA0003599189740000091
As can be seen from table 1, as the bacteriostatic effect of the blumea balsamifera extract is in direct proportion to the concentration thereof, the bacteriostatic effect is reduced when the concentration of the extract is reduced.
2. Sensory evaluation of mouthwashes
2.1 through orthogonal experimental result data of mouthwash formula optimization, it can be seen that the main and secondary relations of each factor influencing sensory quality are as follows: 1, 2-propanediol>Glycerol>Blumea balsamifera extract>Sodium benzoate>Xylitol, its preparation method and application>Tween 80>Peppermint oil. By range analysis, the optimal combination A of mouthwash formulations was determined3B2C2D1E1F2G3Optimal matching with visual analysisSquare combination A3B1C2D1E3F2G3Different, further experiments were performed. Combination protocol A under validated experimental conditions3B2C2D1E1F2G3Has a sensory score of 80.0 points slightly higher than A3B1C2D1E3F2G3Sensory score of (73.3 points). A. the3B2C2D1E1F2G3The combined mouthwash has the best sensory quality score;
2.2 sensory evaluation of mouthwashes
Sensory evaluation was performed according to the sensory evaluation scoring criteria for mouthwashes in table 2.
TABLE 2 sensory evaluation standard table for mouthwash
Figure BDA0003599189740000092
Figure BDA0003599189740000101
A3B2C2D1E1F2G3The sensory evaluation score of the combination regimen was 80.0 points, the formula of the invention had the highest score: 16% of blumea balsamifera extract, 6.6% of xylitol, 800.42% of tween, 2.5% of 1, 2-propylene glycol, 0.06% of sodium benzoate, 4.3% of glycerol, 0.15% of peppermint oil and 69.97% of blumea balsamifera water.
3. Stability test
The mouth wash prepared according to the invention in example 6 was tested according to the national standards of (QB/T2945-2012) oral cleaning and nursing liquid for the physicochemical indexes of the product.
Under the condition of room temperature, the product solution is clear and has no macroscopic impurities; placing in a constant temperature incubator at 40 + -1 deg.C for 24 hr, taking out, returning to room temperature, and observing for no delamination or turbidity; and (3) placing the mixture in a refrigerator at 0-4 ℃ for 24 hours, taking out, recovering to room temperature, observing, and preventing the phenomena of layering, turbidity and the like, wherein the color is stable.
Although the invention has been described herein with reference to a number of illustrative embodiments thereof, it should be understood that numerous other modifications and embodiments can be devised by those skilled in the art that will fall within the spirit and scope of the principles of this disclosure. More specifically, various variations and modifications are possible in the component parts and/or arrangements of the subject combination arrangement within the scope of the disclosure, the drawings and the appended claims. In addition to variations and modifications in the component parts and/or arrangements, other uses will also be apparent to those skilled in the art.

Claims (5)

1. An alcohol-free mouth wash which is characterized in that: comprises the following raw materials: blumea balsamifera extract, xylitol, tween 80, 1, 2-propylene glycol, sodium benzoate, glycerol, peppermint oil and blumea balsamifera aromatic water.
2. The non-alcoholic mouthwash according to claim 1, wherein: the composite material comprises the following raw materials in parts by weight: 16% of blumea balsamifera extract, 6.6% of xylitol, 800.42% of tween, 2.5% of 1, 2-propylene glycol, 0.06% of sodium benzoate, 4.3% of glycerol, 0.15% of peppermint oil and 69.97% of blumea balsamifera aromatic water.
3. A preparation method of alcohol-free mouth wash is characterized by comprising the following steps: the method comprises the following steps:
1) preparing the blumea balsamifera extract: extracting with ethanol to obtain herba Blumeae Balsamiferae extract;
2) dissolving xylitol in oleum Blumeae Balsamiferae aromatic water under stirring, adding tween 80, and stirring to obtain clear water solution; adding sodium benzoate into 1, 2-propylene glycol, stirring, adding glycerol and oleum Menthae Dementholatum, stirring to obtain alcoholic solution, mixing the aqueous solution and alcoholic solution, stirring, adding herba Blumeae Balsamiferae extract, diluting with deionized water for extracting herba Blumeae Balsamiferae to 60mL, and autoclaving to obtain collutory.
4. The non-alcoholic mouthwash according to claim 3, wherein: the preparation method of the blumea balsamifera extract comprises the following specific steps: taking blumea balsamifera, and mixing the blumea balsamifera with the liquid-liquid ratio of 1: 8g/mL, using 75% ethanol, condensing and refluxing for 60min at the temperature of 60 ℃, filtering, combining the filtrates, and concentrating to 1/10 of the volume of the filtrate for later use.
5. The non-alcoholic mouthwash according to claim 4, wherein: the blumea balsamifera needs to be extracted repeatedly for 2 times.
CN202210399596.1A 2022-04-15 2022-04-15 Alcohol-free mouth wash and preparation method thereof Pending CN114569519A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817295A (en) * 1994-05-02 1998-10-06 Warner-Lambert Company Alcohol free mouthwash
CN102512344A (en) * 2011-12-28 2012-06-27 中国热带农业科学院热带作物品种资源研究所 Blumea balsamifera extract, preparation method and application thereof in oral care and clean product
CN105193665A (en) * 2015-10-26 2015-12-30 中国热带农业科学院热带作物品种资源研究所 Blumea balsamifera oral care solution, and preparation method and application thereof
CN106473961A (en) * 2016-12-02 2017-03-08 丹东康齿灵保洁用品有限公司 A kind of gargarism and preparation method
CN113750198A (en) * 2021-10-21 2021-12-07 中国热带农业科学院热带作物品种资源研究所 Compound oral care solution and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817295A (en) * 1994-05-02 1998-10-06 Warner-Lambert Company Alcohol free mouthwash
CN102512344A (en) * 2011-12-28 2012-06-27 中国热带农业科学院热带作物品种资源研究所 Blumea balsamifera extract, preparation method and application thereof in oral care and clean product
CN105193665A (en) * 2015-10-26 2015-12-30 中国热带农业科学院热带作物品种资源研究所 Blumea balsamifera oral care solution, and preparation method and application thereof
CN106473961A (en) * 2016-12-02 2017-03-08 丹东康齿灵保洁用品有限公司 A kind of gargarism and preparation method
CN113750198A (en) * 2021-10-21 2021-12-07 中国热带农业科学院热带作物品种资源研究所 Compound oral care solution and preparation method thereof

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