CN114569331B - Spontaneous fluid transport dressing based on continuous asymmetric super-hydrophilic channel and preparation method thereof - Google Patents
Spontaneous fluid transport dressing based on continuous asymmetric super-hydrophilic channel and preparation method thereof Download PDFInfo
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0203—Adhesive plasters or dressings having a fluid handling member
- A61F13/0206—Adhesive plasters or dressings having a fluid handling member the fluid handling member being absorbent fibrous layer, e.g. woven or nonwoven absorbent pad, island dressings
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- A61F13/01017—
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- A61F13/01029—
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0203—Adhesive plasters or dressings having a fluid handling member
- A61F13/022—Adhesive plasters or dressings having a fluid handling member having more than one layer with different fluid handling characteristics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0259—Adhesive plasters or dressings characterised by the release liner covering the skin adhering layer
- A61F13/0266—Adhesive plasters or dressings characterised by the release liner covering the skin adhering layer especially adapted for wound covering/occlusive dressings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F13/0286—Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of non adhesive dressings
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Abstract
The invention provides a spontaneous fluid transport dressing based on continuous asymmetric super hydrophilic channels and a preparation method thereof, wherein the dressing comprises the following components: the porous water absorption layer is used for absorbing and discharging liquid; the stratum basale, the stratum basale be provided with link up, be used for transporting the liquid to the liquid transport passageway on porous water absorption layer, liquid transport passageway is including the perforating hole and the hydrophilic passageway of intercommunication, wherein, is close to porous water absorption layer for the binding off in hydrophilic passageway's the both ends opening, is close to the wound and is the opening, and opening width is greater than the binding off width. The dressing is directly applied to the upper part of a wound to be broken, and the basal layer of the liquid conveying channel with the communicating structure is tightly combined with the wound. Under the drive of capillary force, wound exudate is spontaneously enriched in the hydrophilic channel and is transported outwards to the porous water absorption layer through the through hole structure, so that the in-situ separation and active discharge of the wound exudate are realized.
Description
Technical Field
The invention belongs to the field of medical devices and materials, and particularly relates to a spontaneous fluid transport dressing based on a continuous asymmetric super-hydrophilic channel and a preparation method thereof.
Background
The method for regulating and controlling the collection behavior of the fluid by utilizing the special interaction between the interface and the fluid is a key problem in the current material science research. In disaster medicine, emergency treatment and protection of ulceration type wounds are important means for improving survival rate of wounded persons. The dressing is used for hemostasis treatment, but in the existing research, the adopted dressing is mostly simple in plugging, and the extravasated liquid at the burst position cannot be actively discharged, so that the secondary infection of the wounded and the wound healing are slowed down. On the other hand, continuous discharge of the extravasated liquid cannot be achieved by treatment with a simple liquid-absorbent dressing. Secondary injury to the wound of the victim can also occur when changing the absorbent dressing. Therefore, the intelligent dressing capable of fitting the wound for a long time and actively discharging the exosmosis is designed, and has a positive effect on treatment of the ulcerated wound.
Disclosure of Invention
In view of the above, the present invention provides a self-fluid-transporting dressing based on continuous asymmetric super-hydrophilic channels and a preparation method thereof, aiming at overcoming the defects in the prior art.
In order to achieve the purpose, the technical scheme of the invention is realized as follows:
a self-fluid transport dressing based on continuous asymmetric superhydrophilic channels, comprising:
a porous water-absorbing layer for absorbing and discharging liquid;
the stratum basale, the stratum basale is provided with the liquid transport passageway that link up, be used for transporting liquid to porous layer that absorbs water, liquid transport passageway is including the perforating hole and the hydrophilic passageway of intercommunication, wherein, is close up for porous layer that absorbs water in the both ends opening of hydrophilic passageway, and be the opening near the wound, and the opening width is greater than the width of closing up.
Preferably, the hydrophilic channels in the substrate layer are arranged in a regular array, and the cross section of the hydrophilic channels is in a regular shape.
Preferably, the cross section of the hydrophilic channel is one or more of a hexagon, a quadrangle or a triangle.
Preferably, the length of the hydrophilic channel is 0.5-2 mm, the depth is 0.1-2 mm, the width of the opening is 0.1-2 mm, and the width of the closing-in channel is 0.1-1 mm.
Preferably, the through hole is a square hole channel or a circular hole channel, the aperture of the through hole is 0.1-1 mm, and the depth of the through hole is 0.1-1 mm.
Preferably, the thickness of the porous water absorption layer is 0.1-1 mm, and the pore diameter of the porous material is 0.01-0.5 mm.
Preferably, the surface of the liquid transport channel is provided with a hydrophilic coating for accelerating liquid transport.
Preferably, the hydrophilic coating has a static contact angle of a drop of water of less than 10 °, preferably less than 5 °.
Preferably, the main components of the hydrophilic coating comprise alkaline silica sol, polyacrylic acid, hydrophilic silica nanoparticles, a nonionic surfactant, a hydrophilic polymer and deionized water, and the weight ratio of the hydrophilic coating to the nonionic surfactant is (1-5): (0.5-1): (0.2-0.5): 0.1: (0.5-1): 100.
preferably, the hydrophilic polymer is a hydrophilic polymer material having a sugar ring structure.
More preferably, the hydrophilic polymer is one or a mixture of several of hydroxypropyl cellulose, carboxymethyl cellulose, sulfonic acid modified cellulose, chitosan oligosaccharide and glucan.
More preferably, the nonionic surfactant is Triton X-100 (polyethylene glycol octyl phenyl ether).
Preferably, the material of the substrate layer is polyester, polyvinyl alcohol fiber, polyurethane or cellulose.
Preferably, the porous water absorption layer is hydrophilic cellulose, polyurethane or polyester fiber.
The invention also provides a preparation method of the spontaneous fluid transport dressing based on the continuous asymmetric super hydrophilic channel, which comprises the following steps:
(1) forming a liquid conveying channel on the substrate layer by the processes of laser cutting, template secondary replication or mechanical micromachining;
(2) mixing alkaline silica sol, polyacrylic acid, hydrophilic silicon dioxide nano particles, a non-ionic surfactant, a hydrophilic polymer and deionized water to prepare a coating solution;
(3) cleaning the substrate layer processed in step (1) by air/O 2 After plasma activation, immersing the substrate layer into the coating solution prepared in the step (2), taking out and drying, cleaning after drying, and drying again to obtain the coating with the hydrophilic coatingA base layer;
(4) and (3) attaching or pressing the porous water absorption layer on the surface of the substrate layer to obtain the spontaneous fluid transport dressing based on the continuous asymmetric super hydrophilic channel.
The polyacrylic acid and the hydrophilic polymer material are assembled by hydrogen bonds through carboxyl on an alkyl chain and hydroxyl on a sugar ring, so that the structure of the coating is stabilized to the maximum extent. The alkali silica sol is gradually condensed to form SiO with a continuous network structure in the process of dehydration and drying 2 And the structure further promotes the hydrophilicity of the coating to be improved. In addition, the added hydrophilic silica nano particles are used as fillers, so that micron-sized holes of the coating can be increased, and the rapid spreading of liquid is facilitated. The reasonable compatibility of polyacrylic acid, hydrophilic polymer and alkaline silica sol can realize the characteristics of hydrophilicity and water resistance of the coating.
Compared with the prior art, the invention has the following advantages:
the spontaneous fluid transport dressing based on the continuous asymmetric super-hydrophilic channel is directly applied to the upper side of a wound and is broken, and the basal layer of the liquid transport channel with the communicated structure is tightly combined with the wound. Under the drive of capillary force, wound exudate is spontaneously enriched in the hydrophilic channel and is transported outwards to the porous water absorption layer through the through hole structure, so that the in-situ separation and active discharge of the wound exudate are realized. Meanwhile, by adding liquid medicine, the medicine can be mixed and dissolved in the liquid and externally poured into the wound, so as to achieve the synergistic treatment effect.
Drawings
Fig. 1 is a schematic view of a configuration of a continuous asymmetric superhydrophilic channel based spontaneous fluid transport dressing according to an embodiment of the invention.
Fig. 2 shows the healing of rat wound in application example.
Description of the reference numerals:
1. a porous water-absorbing layer; 2. a base layer; 21. a through hole; 22. a hydrophilic channel; 23. a hydrophilic coating.
Detailed Description
Unless defined otherwise, technical terms used in the following examples have the same meanings as commonly understood by one of ordinary skill in the art to which the present invention belongs. The test reagents used in the following examples, unless otherwise specified, are all conventional biochemical reagents; the experimental methods are conventional methods unless otherwise specified.
The invention will be described in detail with reference to the following examples.
A dressing based on continuous asymmetric super hydrophilic channels for spontaneous fluid transport, as shown in figure 1, comprises a porous water-absorbing layer and a substrate layer, wherein the porous water-absorbing layer is used for absorbing liquid transported by the substrate layer and discharging the liquid; the stratum basale is provided with the liquid transport passageway that link up, be used for transporting liquid to porous layer that absorbs water, and liquid transport passageway includes the perforating hole and the hydrophilic passageway that communicate each other, and wherein, be close to porous layer that absorbs water for the binding off in hydrophilic passageway's the both ends opening, be close to the wound for the opening, and opening width is greater than the binding off width.
The cross section of the hydrophilic channel is in a regular array structure, the cross section is regularly arranged in a hexagonal shape, a quadrilateral shape and a triangular shape, and the longitudinal and transverse sections of the hydrophilic channel are in vertically and horizontally asymmetrical shapes such as a trapezoid shape. The through holes are integrated with the hydrophilic channels to form an upward through structure, and a liquid conveying channel for liquid to move from the lower surface to the upper surface of the substrate layer is formed. The porous water absorption layer is made of porous materials and pushes the active separation and the continuous discharge of liquid. The hydrophilic channel, the through hole and the porous water absorption layer form a unified integrated system, and active discharge of extravasated liquid at the wound is realized.
The liquid conveying channel is prepared by the existing processes of laser cutting, template secondary replication or mechanical micromachining and the like. The substrate layer may use a polyester sheet, polyvinyl alcohol fiber, polyurethane sheet, or cellulose sheet material.
The length of the hydrophilic channel is 0.5-2 mm, the depth is 0.1-2 mm, the width of the opening is 0.1-2 mm, and the width of the closing opening is 0.1-1 mm.
The diameter of the through hole is 0.1-1 mm, the length is 0.1-1 mm, the through hole is cylindrical or square, is positioned right above the connection part of the hydrophilic channel and is vertical to the super-hydrophilic channel.
The thickness of the porous water absorption layer is 0.1-1 mm, the aperture is 0.01-0.5 mm, and the material is hydrophilic cellulose, polyurethane or polyester fiber.
Hydrophilic channels in the liquid conveying channel are tightly connected in the basal layer in a hexagonal, quadrangular or triangular mode to form a regular array structure, and finally the integrated size is 1-1000 mm.
In addition, to promote wound healing, the application of a liquid therapeutic agent to the outer surface of the dry porous absorbent layer provides spontaneous delivery to the wound site by liquid miscibility, resulting in a synergistic therapeutic approach.
To further speed up the discharge of the liquid, the surface of the liquid transport channels is provided with a hydrophilic coating. The main components of the hydrophilic coating comprise alkaline silica sol, polyacrylic acid, hydrophilic silicon dioxide nano particles, a nonionic surfactant, a hydrophilic polymer and deionized water, and the weight ratio of the components is (1-5): (0.5-1): (0.2-0.5): 0.1: (0.5-1): 100. the hydrophilic polymer is hydroxypropyl cellulose. The non-ionic surfactant is Triton X-100 (polyethylene glycol octyl phenyl ether), the static contact angle of the prepared hydrophilic coating is less than 10 degrees, and 1 microliter of liquid drops are completely spread within 100 milliseconds.
The preparation method of the spontaneous fluid transport dressing based on the continuous asymmetric super-hydrophilic channel comprises the following steps:
(1) and forming a liquid conveying channel on the substrate layer by using the processes of laser cutting, template secondary replication or mechanical micromachining.
(2) Mixing alkaline silica sol, polyacrylic acid, hydrophilic silicon dioxide nano particles, a non-ionic surfactant, a hydrophilic polymer and deionized water to prepare a coating solution;
(3) cleaning the substrate layer processed in step (1) by air/O 2 After the plasma activation, immersing the substrate layer into the coating solution prepared in the step (2), taking out, drying, cleaning after drying, and drying again to obtain the substrate layer with the hydrophilic coating, wherein the static contact angle of the substrate layer is less than 10 degrees;
(4) and directly bonding or pressing the porous water absorption layer on the surface of the through hole in the substrate layer to obtain the spontaneous fluid transport dressing based on the continuous asymmetric super hydrophilic channel.
The prepared spontaneous fluid transport dressing based on the continuous asymmetric super-hydrophilic channel is directly applied to the upper part of a wound and is broken, and the hydrophilic channel surface is tightly combined with the wound. Under the drive of capillary force, wound exudate is spontaneously enriched in the hydrophilic channel and is transported outwards to the porous water absorption layer through the through hole structure, so that in-situ separation and active discharge of the wound exudate are realized. Meanwhile, by adding liquid medicine, the medicine can be mixed and dissolved in the liquid and externally poured into the wound, so as to achieve the synergistic treatment effect.
Example 1
This example serves to illustrate the effect of the hydrophilic coating component formulation on its hydrophilic properties, while a blank control was set.
The raw material components of the hydrophilic coating layer were mixed to prepare a coating solution, the component ratios of the examples and comparative examples are shown in table 1, the polyester sheet was immersed in the coating solution for 10min and then taken out to be dried to obtain a polyester sheet having a surface coated with the hydrophilic coating layer, and the polyester sheet having a surface coated with the hydrophilic coating layer was subjected to contact angle measurement by the following method:
the contact angle measuring apparatus SDC-200 manufactured by SFMIT was used as the measuring apparatus. Deionized water was used in the contact angle determination.
The specific operation method comprises the following steps: the amount of liquid discharged from the micro-syringe (micro-syringe having a capacity of 500. mu.l, manufactured by SFMIT) was set to 4. mu.l, and water droplets were dropped directly on the interface material. The state of droplet dripping was recorded by a horizontally placed camera. The contact angle measuring instrument is connected with a computer provided with SDC-200 contact angle measuring instrument software, and the microsyringe and the camera are controlled by the SDC-200 contact angle measuring instrument software. And then the image analysis is carried out by using software.
In the determination, the dropping moment of the liquid drop on the surface of the interface material is subjected to image capture, and image analysis is performed through SDC-200 contact angle measuring instrument software (software version 2.0, the measuring method is a sitting drop method, the calculating method is an angle measuring method, and the image processing mode is single sheet), so that the included angle formed by the tangent line of the contact interface between the water drop and the air and the interface between the water drop and the interface material is calculated and used as the contact angle.
The interface material was placed on a sample stage of a contact angle measuring apparatus, and contact angles were measured at 5 points different from the 1 piece of interface material while maintaining the level. In each of the above-mentioned portions, the contact angle of the interface material is defined as an average value (rounded at 2 nd position below decimal point) of 5 contact angle measurement values.
The coating solution was prepared according to the following table:
table 1 coating solution composition ratios in example 1
| Components | Alkaline silica sol | Polyacrylic acid | Hydrophilic silica nanoparticles | Triton X-100 | Hydroxypropyl cellulose | Deionized | Polyvinyl alcohol | |
| 1 | 1 | 0.5 | 0.2 | 0.1 | 0.5 | 100 | - | |
| 2 | 3 | 0.7 | 0.4 | 0.1 | 0.6 | 100 | - | |
| 3 | 5 | 1 | 0.5 | 0.1 | 1 | 100 | - | |
| 4 | - | 0.5 | 0.2 | 0.1 | 0.5 | 100 | - | |
| 5 | 3 | - | 0.4 | 0.1 | 0.6 | 100 | - | |
| 6 | 5 | 1 | 0.5 | 0.1 | - | 100 | - | |
| 7 | - | - | 1.5 | - | - | 100 | 1 | |
| Control group | - | - | - | - | - | - | - |
TABLE 2 measurement results of examples and comparative examples
| | Contact angle | |
| 1 | 8.0°± 2.4° | |
| 2 | 5.5°± 1.5° | |
| 3 | 6.8°± 2.4° | |
| 4 | 6.9 ° ± 1.9 ° (soluble in water) | |
| 5 | 5.1 degree +/-0.9 degree (easy to separate) | |
| 6 | 4.3 degree +/-1.0 degree (easy to separate) | |
| 7 | 16.8°± 1.0° | |
| Control group | 51.9°± 6.1° |
From the measurements in the table above, it can be seen that: the contact angle of the hydrophilic coating prepared by the groups 1-3 is obviously lower than that of the groups 4-7 and the contrast group, and the hydrophilicity of the coating can be obviously improved by reasonably matching the polyacrylic acid, the hydrophilic polymer and the alkaline silica sol.
Examples 2 and 3 and comparative examples 1 and 2 for explaining the influence of liquid spreading time on the shape of liquid transporting channel
Example 2
(1) Preparation of the base layer
The dimensions of the hydrophilic channel are designed as follows: the length is 2mm, the depth is 0.5mm, the width of the opening is 2mm, and the width of the closing-in is 1 mm. Direct engraving on flexible polyester sheets using a mechanical micro-processor-engraving machine in combination with a tool with a triangular tipA channel structure having a tapered cross-section. And setting parameters of an engraving machine, directly engraving the substrate at the convergence position of the channel to form a through hole, wherein the diameter of the through hole is 1mm, the length of the through hole is 1mm, and the through hole is positioned right above the joint of the hydrophilic channel and is vertical to the hydrophilic channel. Finally forming the polyester sheet with a hydrophilic channel with a trapezoidal longitudinal section and a square cross section and a cylindrical through hole structure communicated with the hydrophilic channel. Subjecting the polyester sheet to air/O for 5 minutes 2 Plasma treatment, soaking for 5 minutes by using the coating solution prepared in example 1, and drying to obtain a polyester sheet with hydrophilic channels.
(2) Preparation of a continuous asymmetric channel-based spontaneous fluid transport dressing
A cellulose fiber membrane having a thickness of 1mm and a pore diameter of 0.1mm was hot-pressed over the polyester sheet to form a porous water-absorbent layer. Finally, the spontaneous fluid transport dressing based on the continuous asymmetric super hydrophilic channel is obtained.
Example 3
(1) Preparation of the base layer
The dimensions of the hydrophilic channel are designed as follows: the length is 1mm, the depth is 0.5mm, the width of the opening is 2mm, and the width of the closing-in is 1 mm. The channel structure with a conical section is directly engraved on the polyurethane elastic sheet by using a mechanical micro-machining-engraving machine in combination with a cutter with a triangular tip. Setting parameters of an engraving machine, directly engraving the substrate at the convergence position of the channel to form a through hole, wherein the diameter of the through hole is 1mm, the length of the through hole is 1mm, and the through hole is positioned right above the connection position of the hydrophilic channel and is vertical to the hydrophilic channel. Finally, the polyurethane sheet with the hydrophilic channel with the trapezoidal longitudinal section and the square cross section and the cylindrical through hole structure communicated with the hydrophilic channel is formed. Subjecting the polyurethane sheet to air/O for 5 minutes 2 Plasma treatment, then soaking for 5 minutes by using the coating solution prepared in example 1, and drying to obtain the polyurethane sheet with hydrophilic channels.
(2) Preparation of a self-fluid-transporting dressing based on continuous asymmetric superhydrophilic channels
A cellulose fiber membrane with a thickness of 1mm and a pore diameter of 0.1mm was hot-pressed on the polyurethane sheet to form a porous water-absorbing layer. Finally obtaining the spontaneous fluid transport dressing based on the continuous asymmetric super hydrophilic channel.
Comparative example 1
(1) Preparation of the base layer
Cylindrical channel structures were directly engraved on flexible polyester sheets using a mechanical micro-machining-engraving machine in combination with a tool having a triangular tip. Setting parameters of a carving machine, directly carving through the substrate to form a through hole, wherein the diameter of the through hole is 1mm, and the length of the through hole is 1.5 mm. Subjecting a flexible polyester sheet with cylindrical channels to 5 min air/O 2 Plasma treatment, soaking for 5 minutes by using the coating solution prepared in example 1, and drying to obtain a polyester sheet with hydrophilic channels.
(2) Preparation of spontaneous fluid transport dressing based on symmetric super-hydrophilic channels
A cellulose fiber membrane having a thickness of 1mm and a pore diameter of 0.1mm was hot-pressed over the polyester sheet to form a porous water-absorbent layer. Finally obtaining the spontaneous fluid transport dressing based on the symmetrical super hydrophilic channels.
Comparative example 2
(1) Preparation of the base layer
Cylindrical channel structures were directly engraved on flexible polyester sheets using a mechanical micro-machining-engraving machine in combination with a tool with triangular tips. Setting parameters of a carving machine, directly carving through the substrate to form a through hole, wherein the diameter of the through hole is 1mm, and the length of the through hole is 1.5 mm.
(2) Preparation of fluid-based delivery dressings
A cellulose fiber membrane having a thickness of 1mm and a pore size of 0.1mm was hot-pressed on top of a flexible polyester sheet to form a porous water-absorbent layer. Ultimately resulting in a fluid transport dressing.
Liquid spreading test method:
the interface material was horizontally placed on a bench, 1 microliter of aqueous liquid (stained with red aqueous dye) was aspirated with a microsyringe, the interface material to be measured was dropped vertically, and a liquid spreading video was taken with a high-speed camera. The time after the liquid began to settle from the contact interface to the point of full access to the channel was recorded. With the directional transportation of the liquid, the upper surface of the interface material will not be dyed, which proves that the interface material has better liquid conductivity.
The test results are as follows:
example 2 is a sheet with asymmetric communicating channels and a super-hydrophilic coating, which can completely guide liquid within 100 milliseconds, and the upper surface does not have obvious liquid accumulation, showing a good rapid guide potential for pus blood; example 3 is a sheet with asymmetric communicating channels and a super-hydrophilic coating, which can completely guide liquid within 100 milliseconds, and has no obvious liquid accumulation on the upper surface, thus showing good rapid guide potential of pus blood. Comparative example 1 only the sheet material which is super-hydrophilic and has a symmetrical channel structure, the initial spreading time is about 1 second, the later liquid drop keeps a cake shape and does not continue to spread, and the water is extracted only by the capillary action in the coating, so that the rapid conduction of surface purulent blood cannot be realized. The dressing prepared in comparative example 2 was a sheet of symmetric channels and not superhydrophilic treated, spreading was almost not observed, and the drop remained spherical for an observable time.
Application example
1. Experimental method and observation indexes:
1.1 preparation of animal model of infection:
healthy adult male rats (Huafukang) 4 with the weight of 180-210g are selected and divided into a control group and a treatment group according to a random numerical table method, wherein each group comprises 2 rats. The rats in group 2 were anesthetized by inhalation with 3% isoflurane, fixed on an operating board in the prone position, the skin on the back was fully exposed, the four limbs were fixed, the skin on the back of the rats was repeatedly wiped with 1% iodophor cotton balls, the back was shaved with an area of about 5 × 5cm, and the depilated area was sterilized. The whole skin of 2cm multiplied by 1.5cm is cut off from the middle and slightly below the back, and the pseudomonas aeruginosa liquid is evenly smeared on the wound surfaces of all rats, wherein each wound surface is 50 mu L. Experimental groups: the dressing (the spontaneous fluid transport dressing prepared in example 2) was wrapped over the wound surface and secured. Control group: the gauze covers the wound surface and is bound and fixed. After model preparation, rats were resuscitated with fluid by intraperitoneal injection of 0.9% sodium chloride. Rats were closely monitored for resuscitation and vital signs. After infection, rats were housed individually in groups with food and water access. Wound conditions were examined daily to avoid additional trauma from being bitten by the herd of rats.
1.2 observation indexes:
after the infection model was prepared, rats were evaluated for dorsal wound surface in Day1, Day3, Day12, Day15, respectively.
2. The experimental results are as follows:
as shown in figure 2, compared with the control group, the rats in the experimental group have better wound healing effect after being covered by the dressing to treat infection.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and should not be taken as limiting the invention, and any modifications, equivalents, improvements and the like that are made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (9)
1. A self-fluid transport dressing based on continuous asymmetric superhydrophilic channels, characterized by: the method comprises the following steps:
a porous water-absorbing layer for absorbing and discharging liquid;
the wound absorbent pad comprises a substrate layer and a plurality of hydrophilic channels, wherein the substrate layer is provided with a liquid conveying channel which is communicated and used for conveying liquid to the porous absorbent layer, the liquid conveying channel comprises a through hole and a hydrophilic channel which are communicated, the through hole is a square hole channel or a circular hole channel, the through hole is positioned right above the joint of the hydrophilic channel and is vertical to the hydrophilic channel, the opening of the two ends of the hydrophilic channel, which is close to the porous absorbent layer, is a closed opening, the opening of the two ends of the hydrophilic channel, which is close to the wound, is an opening, and the opening width is larger than the closed width;
the surface of the liquid conveying channel is provided with a hydrophilic coating for accelerating liquid conveying;
the main components of the hydrophilic coating comprise alkaline silica sol, polyacrylic acid, hydrophilic silicon dioxide nano particles, a nonionic surfactant, a hydrophilic polymer and deionized water, and the weight ratio of the components is (1-5): (0.5-1): (0.2-0.5): 0.1: (0.5-1): 100.
2. the continuous asymmetric superhydrophilic channel-based spontaneous fluid transport dressing of claim 1, wherein: the hydrophilic channels in the substrate layer are arranged in a regular array, and the cross sections of the hydrophilic channels are in a regular shape; the cross section of the hydrophilic channel is one or more of a hexagon, a quadrangle or a triangle.
3. The continuous asymmetric superhydrophilic channel-based spontaneous fluid transport dressing of claim 2, wherein: the length of the hydrophilic channel is 0.5-2 mm, the depth is 0.1-2 mm, the width of the opening is 0.1-2 mm, and the width of the closing-in is 0.1-1 mm.
4. The self-fluid transport dressing based on continuous asymmetric superhydrophilic channels of claim 1, wherein: the thickness of the porous water absorption layer is 0.1-1 mm, and the pore diameter of the porous material is 0.01-0.5 mm.
5. The self-fluid transport dressing based on continuous asymmetric superhydrophilic channels of claim 1, wherein: the hydrophilic coating has a static contact angle of a water droplet of less than 10 °.
6. The self-fluid transport dressing based on continuous asymmetric superhydrophilic channels of claim 1, wherein: the hydrophilic coating has a static contact angle of a water droplet of less than 5 °.
7. The continuous asymmetric superhydrophilic channel-based spontaneous fluid transport dressing of claim 1, wherein:
the hydrophilic polymer is a hydrophilic high molecular material with a sugar ring structure, and the hydrophilic polymer is one or a mixture of more of hydroxypropyl cellulose, carboxymethyl cellulose, sulfonic acid modified cellulose, chitosan oligosaccharide and glucan; the non-ionic surfactant is Triton X-100.
8. The continuous asymmetric superhydrophilic channel-based spontaneous fluid transport dressing of claim 1, wherein: the base layer is made of polyester, polyvinyl alcohol fiber, polyurethane or cellulose, and the porous water absorption layer is made of hydrophilic cellulose, polyurethane or polyester fiber.
9. A method of preparing a continuous asymmetric superhydrophilic channel-based spontaneous fluid transport dressing according to any of claims 1-8, wherein: the preparation method comprises the following steps:
step 1: forming a liquid conveying channel on the substrate layer by the processes of laser cutting, template secondary replication or mechanical micromachining;
and 2, step: mixing alkaline silica sol, polyacrylic acid, hydrophilic silicon dioxide nano particles, a non-ionic surfactant, a hydrophilic polymer and deionized water to prepare a coating solution;
and step 3: cleaning the substrate layer processed in step 1 by air/O 2 After the plasma activation, immersing the substrate layer into the coating solution prepared in the step 2, taking out and drying, cleaning after drying, and drying again to obtain the substrate layer with the hydrophilic coating;
and 4, step 4: and attaching or pressing the porous water absorption layer on the surface of the substrate layer to prepare the spontaneous fluid transport dressing based on the continuous asymmetric super-hydrophilic channel.
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| CN104188760A (en) * | 2014-08-29 | 2014-12-10 | 朱新生 | Dressing for overall absorption of viscous exudates and blood |
| CN111481733A (en) * | 2020-04-22 | 2020-08-04 | 卢丽菊 | Biological medicine wound surface dressing |
| CN112190750A (en) * | 2020-08-27 | 2021-01-08 | 广东工业大学 | Novel 3D bionic skin dressing and preparation method thereof |
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| JP3464587B2 (en) * | 1997-02-28 | 2003-11-10 | ユニ・チャーム株式会社 | Body fluid absorbent articles |
| WO2008004380A1 (en) * | 2006-07-06 | 2008-01-10 | Zuiko Corporation | Wound-covering material |
| WO2009044912A1 (en) * | 2007-10-05 | 2009-04-09 | Harima Chemicals, Inc. | Hydrophilic coating agent, hydrophilic coating film, and hydrophilic base |
| CN108175573B (en) * | 2018-01-17 | 2022-06-03 | 中国科学院理化技术研究所 | Hydrophilic-hydrophobic composite wound dressing for directionally leading out biological fluid and preparation method and application thereof |
| EP3784182A1 (en) * | 2018-04-23 | 2021-03-03 | KCI Licensing, Inc. | Dressing providing apertures with multiple orifice sizes for negative-pressure therapy |
| GB201912071D0 (en) * | 2019-08-22 | 2019-10-09 | Smith & Nephew | Wound dressing |
| CN111686295A (en) * | 2020-06-24 | 2020-09-22 | 重庆理工大学 | Seepage self-adjusting composite dressing and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104188760A (en) * | 2014-08-29 | 2014-12-10 | 朱新生 | Dressing for overall absorption of viscous exudates and blood |
| CN111481733A (en) * | 2020-04-22 | 2020-08-04 | 卢丽菊 | Biological medicine wound surface dressing |
| CN112190750A (en) * | 2020-08-27 | 2021-01-08 | 广东工业大学 | Novel 3D bionic skin dressing and preparation method thereof |
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