CN114558467A - 一种滤蛋白阻菌中空纤维膜及其制备方法和用途 - Google Patents

一种滤蛋白阻菌中空纤维膜及其制备方法和用途 Download PDF

Info

Publication number
CN114558467A
CN114558467A CN202210402084.6A CN202210402084A CN114558467A CN 114558467 A CN114558467 A CN 114558467A CN 202210402084 A CN202210402084 A CN 202210402084A CN 114558467 A CN114558467 A CN 114558467A
Authority
CN
China
Prior art keywords
membrane
nano
hollow fiber
protein
drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202210402084.6A
Other languages
English (en)
Inventor
廖林正
翟富强
柏栋予
李璐
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chongqing University of Arts and Sciences
Original Assignee
Chongqing University of Arts and Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chongqing University of Arts and Sciences filed Critical Chongqing University of Arts and Sciences
Priority to CN202210402084.6A priority Critical patent/CN114558467A/zh
Publication of CN114558467A publication Critical patent/CN114558467A/zh
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/76—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74
    • B01D71/82—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74 characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/165—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart
    • A61M60/17—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart inside a ventricle, e.g. intraventricular balloon pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/884—Constructional details other than related to driving of implantable pumps or pumping devices being associated to additional implantable blood treating devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/884—Constructional details other than related to driving of implantable pumps or pumping devices being associated to additional implantable blood treating devices
    • A61M60/888—Blood filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0086—Mechanical after-treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0095—Drying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B01D69/125—In situ manufacturing by polymerisation, polycondensation, cross-linking or chemical reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7518—General characteristics of the apparatus with filters bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7545—General characteristics of the apparatus with filters for solid matter, e.g. microaggregates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2323/00—Details relating to membrane preparation
    • B01D2323/36—Introduction of specific chemical groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/24—Mechanical properties, e.g. strength
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/48—Antimicrobial properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Mechanical Engineering (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Inorganic Chemistry (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

一种滤蛋白阻菌中空纤维膜，包括纳米纤维丝、多酚类化合物，通过氢键结合构成均一的膜状结构，包括如下步骤制备：1)取纳米纤维丝、多酚类化合物，分别制备为纳米纤维丝分散液、多酚类化合物分散液；2)将多酚类化合物分散液滴加至纳米纤维丝分散液中，且搅拌，得到混合液；3)混合液经抽滤、干燥，得到初级膜；4)初级膜经牵伸、水洗、干燥，得到目标产品。本发明制备的中空纤维膜在具备滤蛋白和阻菌功能的基础上，满足可持续发展需求。

Description

一种滤蛋白阻菌中空纤维膜及其制备方法和用途
技术领域
本发明涉及材料领域，具体涉及一种滤蛋白阻菌中空纤维膜及其制备方法和用途。
背景技术
膜技术广泛用于包括透析、反渗透、微滤、超滤、纳滤、膜反应器等领域。
针对植入式左心室辅助装置，其体内部件包括血液泵组件、入血管和出血管，有助于降低右心衰、主动脉瓣关闭不全、消化道出血等风险，并提高患者生活质量。
这种植入式左心室辅助装置，通常在其血液泵组件入口设置过滤膜，保证红细胞等生物质正常通过，而对其中的细菌具有一定阻滞杀灭作用。目前制备这种过滤膜通常采用高分子石化产品，而纤维素等材料作为可再生的天然高分子材料，如何利用纤维素作为主要原料，用于制备适用于左心室辅助装置的膜材料，是本领域技术人员亟待解决的问题。
发明内容
本发明的目的之一是提供一种滤蛋白阻菌中空纤维膜，其利用可再生天然材料制备而成，在具备滤蛋白和阻菌功能的基础上，满足可持续发展需求。
本发明的目的之二是提供上述滤蛋白阻菌中空纤维膜的制备方法，其制备过程绿色、环保，满足可持续发展需求。
实现本发明目的之一的技术方案是：
一种滤蛋白阻菌中空纤维膜，包括纳米纤维丝、多酚类化合物，通过氢键结合构成均一的膜状结构。
优选的，纳米纤维丝的长度为20-100μm，纳米纤维丝和多酚类化合物的质量比为100：2.5-15。
优选的，所述膜状结构的厚度为10-30μm。
优选的，所述多酚类化合物为单宁酸或多巴胺。
实现本发明目的之二的技术方案是：任一上述滤蛋白阻菌中空纤维素的制备方法，包括如下步骤：
1)取纳米纤维丝、多酚类化合物，分别制备为纳米纤维丝分散液、多酚类化合物分散液；
2)将多酚类化合物分散液滴加至纳米纤维丝分散液中，且搅拌，得到混合液；
3)混合液经抽滤、干燥，得到初级膜；
4)初级膜经牵伸、水洗、干燥，得到目标产品。
优选的，步骤1)采用水作为分散剂，纳米纤维丝分散液的浓度为0.3-8wt％。
优选的，步骤3)所述干燥，为自然阴干，干燥时间为6-8h。
优选的，步骤4)所述干燥，为自然阴干，干燥时间为6-8h。
本发明还请求保护了任一上述滤蛋白阻菌中空纤维膜在用于制备血液膜组件中的用途。
采用上述技术方案具有以下技术效果：
1、本发明滤蛋白阻菌中空纤维膜以纳米纤维丝和多酚类化合物作为原料，均为可再生资源，满足持续发展需求。纳米纤维丝之间和多酚类化合物与纳米纤维丝之间通过多重氢键键合构成膜状结构，可有效提高制备得到的膜状结构的机械强度，满足作为膜过滤组件的使用需求。
2、本发明滤蛋白阻菌中空纤维膜，纳米纤维丝之间通过氢键键合，构成膜主体结构，形成孔隙率高的膜状结构，允许诸如红细胞等正常通过，多酚类化合物通过氢键均匀分布在膜状结构上，其含有丰富的酚羟基，具有抗菌功能，赋予膜状结构灭菌的功能性。
3、本发明制备方法，将纳米纤维丝和多酚类化合物分别制备为分散液，纳米纤维丝分散液先完成键键结合，然后将多酚类化合物分散液通过滴加的方式搅拌加入，使多酚类化合物以氢键形式均匀分布，最后通过抽滤、干燥的方式得到均一的复合膜，具有优异的弯曲-不弯曲稳定性，且整个制备方法工艺简单、环保，利于工业化生产。
下面结合具体实施方式作进一步的说明。
具体实施方式
本发明中，纳米纤维丝可以木浆(纤维素含量90％)为原料，采用TEMPO氧化法制备得到，当然，也可直接从市面购买，多酚类化合物为单宁酸或多巴胺，直接从市面购买。
实施例1
制备0.3wt％纳米纤维丝水分散液，随后，将单宁酸水分散液滴入纳米纤维丝水分散液中，滴入单宁酸的质量占纳米纤维丝的2.5％。室温搅拌6-12h，得到均匀混合溶液；取10ml的均匀混合溶液，置于抽滤杯(带聚四氟乙烯滤膜)中真空抽滤，自然干燥6h，小心从聚四氟乙烯滤膜上揭下，再经牵伸、水洗、自然干燥6h，获得厚度为10μm的滤蛋白阻菌中空纤维膜。
实施例2
制备4wt％纳米纤维丝水分散液，随后，将单宁酸水分散液滴入纳米纤维丝水分散液中，滴入单宁酸的质量占纳米纤维丝的10％。室温搅拌6-12h，得到均匀混合溶液；取10ml的均匀混合溶液，置于抽滤杯(带聚四氟乙烯滤膜)中真空抽滤，自然干燥7h，小心从聚四氟乙烯滤膜上揭下，再经牵伸、水洗、自然干燥7h，获得厚度为20μm的滤蛋白阻菌中空纤维膜。
实施例3
制备8wt％纳米纤维丝水分散液，随后，将单宁酸水分散液滴入纳米纤维丝水分散液中，滴入单宁酸的质量占纳米纤维丝的15％。室温搅拌6-12h，得到均匀混合溶液；取10ml的均匀混合溶液，置于抽滤杯(带聚四氟乙烯滤膜)中真空抽滤，自然干燥8h，小心从聚四氟乙烯滤膜上揭下，再经牵伸、水洗、自然干燥8h，获得厚度为30μm的滤蛋白阻菌中空纤维膜。
实施例4
将实施例1-3制备得到的滤蛋白阻菌中空纤维膜分别作为膜组件，取小鼠血液依次穿过这些膜组件，其小鼠血液可完全穿过，无成分损失，且各膜组件可显著抵抗大肠杆菌和金黄色葡萄球菌。

Claims (9)

1.一种滤蛋白阻菌中空纤维膜，其特征在于，包括纳米纤维丝、多酚类化合物，通过氢键结合构成均一的膜状结构。
2.根据权利要求1所述的滤蛋白阻菌中空纤维膜，其特征在于，纳米纤维丝的长度为20-100μm，纳米纤维丝和多酚类化合物的质量比为100：2.5-15。
3.根据权利要求1所述的滤蛋白阻菌中空纤维膜，其特征在于，所述膜状结构的厚度为10-30μm。
4.根据权利要求1所述的滤蛋白阻菌中空纤维膜，其特征在于，所述多酚类化合物为单宁酸或多巴胺。
5.权利要求1-4任一滤蛋白阻菌中空纤维素的制备方法，其特征在于，包括如下步骤：
1)取纳米纤维丝、多酚类化合物，分别制备为纳米纤维丝分散液、多酚类化合物分散液；
2)将多酚类化合物分散液滴加至纳米纤维丝分散液中，且搅拌，得到混合液；
3)混合液经抽滤、干燥，得到初级膜；
4)初级膜经牵伸、水洗、干燥，得到目标产品。
6.根据权利要求5所述的制备方法，其特征在于，步骤1)采用水作为分散剂，纳米纤维丝分散液的浓度为0.3-8wt％。
7.根据权利要求5所述的制备方法，其特征在于，步骤3)所述干燥，为自然阴干，干燥时间为6-8h。
8.根据权利要求5所述的制备方法，其特征在于，步骤4)所述干燥，为自然阴干，干燥时间为6-8h。
9.权利要求1-4任一滤蛋白阻菌中空纤维膜在用于制备血液膜组件中的用途。
CN202210402084.6A 2022-04-18 2022-04-18 一种滤蛋白阻菌中空纤维膜及其制备方法和用途 Pending CN114558467A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210402084.6A CN114558467A (zh) 2022-04-18 2022-04-18 一种滤蛋白阻菌中空纤维膜及其制备方法和用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210402084.6A CN114558467A (zh) 2022-04-18 2022-04-18 一种滤蛋白阻菌中空纤维膜及其制备方法和用途

Publications (1)

Publication Number Publication Date
CN114558467A true CN114558467A (zh) 2022-05-31

Family

ID=81720958

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210402084.6A Pending CN114558467A (zh) 2022-04-18 2022-04-18 一种滤蛋白阻菌中空纤维膜及其制备方法和用途

Country Status (1)

Country Link
CN (1) CN114558467A (zh)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105064040A (zh) * 2015-09-14 2015-11-18 北京化工大学 一种多孔疏水材料表面的亲水性改性方法
CN107073192A (zh) * 2014-09-29 2017-08-18 旭化成医疗株式会社 中空纤维膜型血液净化装置
CN108686521A (zh) * 2017-03-31 2018-10-23 旭化成医疗株式会社 中空纤维膜、中空纤维膜型血液净化器
CN108721696A (zh) * 2018-06-19 2018-11-02 佛山皖阳生物科技有限公司 一种人工血管用高机械强度型纤维膜材料的制备方法
US20190276787A1 (en) * 2018-03-09 2019-09-12 The Regents Of The University Of California Biomimetic membranes, methods of manufacture and uses thereof
CN111286067A (zh) * 2020-02-06 2020-06-16 中国科学院青岛生物能源与过程研究所 聚多巴胺-纤维素纳米纤丝光热转化复合膜
CN112920440A (zh) * 2021-04-02 2021-06-08 北京理工大学 一种纳米纤维素基复合膜及其制备方法和用途

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107073192A (zh) * 2014-09-29 2017-08-18 旭化成医疗株式会社 中空纤维膜型血液净化装置
CN105064040A (zh) * 2015-09-14 2015-11-18 北京化工大学 一种多孔疏水材料表面的亲水性改性方法
CN108686521A (zh) * 2017-03-31 2018-10-23 旭化成医疗株式会社 中空纤维膜、中空纤维膜型血液净化器
US20190276787A1 (en) * 2018-03-09 2019-09-12 The Regents Of The University Of California Biomimetic membranes, methods of manufacture and uses thereof
CN108721696A (zh) * 2018-06-19 2018-11-02 佛山皖阳生物科技有限公司 一种人工血管用高机械强度型纤维膜材料的制备方法
CN111286067A (zh) * 2020-02-06 2020-06-16 中国科学院青岛生物能源与过程研究所 聚多巴胺-纤维素纳米纤丝光热转化复合膜
CN112920440A (zh) * 2021-04-02 2021-06-08 北京理工大学 一种纳米纤维素基复合膜及其制备方法和用途

Similar Documents

Publication Publication Date Title
Hoenich Cellulose for medical applications: past, present and future
CN101505858B (zh) 阴离子聚合物的胶体悬浮液用于处理医疗用支持物的用途
CN100467680C (zh) 抗菌蚕丝复合纳米纤维材料及其制备方法
Sindhu et al. Medical applications of cellulose and its derivatives: present and future
CN100395009C (zh) 一种抗菌中空纤维膜的制备方法
CN107583472A (zh) 一种纳米纤维素/滤纸复合过滤膜材料的制备方法
CN101439268B (zh) 高强度高通量聚偏氟乙烯中空纤维膜的制备方法
CN112717194B (zh) 一种可降解壳聚糖基复合止血薄膜
CN105311668A (zh) 一种细菌纤维素复合氧化亚铜抗菌敷料及其制备方法
CN104225669A (zh) 生物活性细菌纤维素-玉米醇溶蛋白复合膜及其制备方法
CN104906623B (zh) 一种纤维素基敷料及其制备方法和应用
CN105175558B (zh) 一种复合膜的制备方法
CN105214508A (zh) 含竹浆纳米纤维素涂层的静电纺丝超滤膜的制备方法
CN114558467A (zh) 一种滤蛋白阻菌中空纤维膜及其制备方法和用途
CN114534527B (zh) 一种膜过滤组件
CN110756066B (zh) 一种磺化柠檬酸壳聚糖改性聚砜血液透析膜及其制备方法
Yao et al. Membranes for the life sciences and their future roles in medicine
CN107684636A (zh) 一种抗菌组合物以及由其所得的细菌纤维素抗菌复合材料
CN106606935A (zh) 血液透析用抗菌复合中空纤维膜及其制备方法
CN110028840A (zh) 一种纳米纤维素生物打印凝胶油墨的制备方法
CN104437127A (zh) 一种聚酯抗凝血血液透析膜及其制备方法
CN113069935A (zh) 一种基于银离子抑菌功能的过滤膜及其制备方法
CN113005633A (zh) 一种抗菌纳米纤维膜及其制备方法和应用
CN109097418A (zh) 原位制备抗菌性细菌纤维素膜的方法
CN110791829A (zh) 一种纳米抗菌纤维的制备方法及其应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20220531

RJ01 Rejection of invention patent application after publication