CN114558467A - 一种滤蛋白阻菌中空纤维膜及其制备方法和用途 - Google Patents
一种滤蛋白阻菌中空纤维膜及其制备方法和用途 Download PDFInfo
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Abstract
一种滤蛋白阻菌中空纤维膜,包括纳米纤维丝、多酚类化合物,通过氢键结合构成均一的膜状结构,包括如下步骤制备:1)取纳米纤维丝、多酚类化合物,分别制备为纳米纤维丝分散液、多酚类化合物分散液;2)将多酚类化合物分散液滴加至纳米纤维丝分散液中,且搅拌,得到混合液;3)混合液经抽滤、干燥,得到初级膜;4)初级膜经牵伸、水洗、干燥,得到目标产品。本发明制备的中空纤维膜在具备滤蛋白和阻菌功能的基础上,满足可持续发展需求。
Description
技术领域
本发明涉及材料领域,具体涉及一种滤蛋白阻菌中空纤维膜及其制备方法和用途。
背景技术
膜技术广泛用于包括透析、反渗透、微滤、超滤、纳滤、膜反应器等领域。
针对植入式左心室辅助装置,其体内部件包括血液泵组件、入血管和出血管,有助于降低右心衰、主动脉瓣关闭不全、消化道出血等风险,并提高患者生活质量。
这种植入式左心室辅助装置,通常在其血液泵组件入口设置过滤膜,保证红细胞等生物质正常通过,而对其中的细菌具有一定阻滞杀灭作用。目前制备这种过滤膜通常采用高分子石化产品,而纤维素等材料作为可再生的天然高分子材料,如何利用纤维素作为主要原料,用于制备适用于左心室辅助装置的膜材料,是本领域技术人员亟待解决的问题。
发明内容
本发明的目的之一是提供一种滤蛋白阻菌中空纤维膜,其利用可再生天然材料制备而成,在具备滤蛋白和阻菌功能的基础上,满足可持续发展需求。
本发明的目的之二是提供上述滤蛋白阻菌中空纤维膜的制备方法,其制备过程绿色、环保,满足可持续发展需求。
实现本发明目的之一的技术方案是:
一种滤蛋白阻菌中空纤维膜,包括纳米纤维丝、多酚类化合物,通过氢键结合构成均一的膜状结构。
优选的,纳米纤维丝的长度为20-100μm,纳米纤维丝和多酚类化合物的质量比为100:2.5-15。
优选的,所述膜状结构的厚度为10-30μm。
优选的,所述多酚类化合物为单宁酸或多巴胺。
实现本发明目的之二的技术方案是:任一上述滤蛋白阻菌中空纤维素的制备方法,包括如下步骤:
1)取纳米纤维丝、多酚类化合物,分别制备为纳米纤维丝分散液、多酚类化合物分散液;
2)将多酚类化合物分散液滴加至纳米纤维丝分散液中,且搅拌,得到混合液;
3)混合液经抽滤、干燥,得到初级膜;
4)初级膜经牵伸、水洗、干燥,得到目标产品。
优选的,步骤1)采用水作为分散剂,纳米纤维丝分散液的浓度为0.3-8wt%。
优选的,步骤3)所述干燥,为自然阴干,干燥时间为6-8h。
优选的,步骤4)所述干燥,为自然阴干,干燥时间为6-8h。
本发明还请求保护了任一上述滤蛋白阻菌中空纤维膜在用于制备血液膜组件中的用途。
采用上述技术方案具有以下技术效果:
1、本发明滤蛋白阻菌中空纤维膜以纳米纤维丝和多酚类化合物作为原料,均为可再生资源,满足持续发展需求。纳米纤维丝之间和多酚类化合物与纳米纤维丝之间通过多重氢键键合构成膜状结构,可有效提高制备得到的膜状结构的机械强度,满足作为膜过滤组件的使用需求。
2、本发明滤蛋白阻菌中空纤维膜,纳米纤维丝之间通过氢键键合,构成膜主体结构,形成孔隙率高的膜状结构,允许诸如红细胞等正常通过,多酚类化合物通过氢键均匀分布在膜状结构上,其含有丰富的酚羟基,具有抗菌功能,赋予膜状结构灭菌的功能性。
3、本发明制备方法,将纳米纤维丝和多酚类化合物分别制备为分散液,纳米纤维丝分散液先完成键键结合,然后将多酚类化合物分散液通过滴加的方式搅拌加入,使多酚类化合物以氢键形式均匀分布,最后通过抽滤、干燥的方式得到均一的复合膜,具有优异的弯曲-不弯曲稳定性,且整个制备方法工艺简单、环保,利于工业化生产。
下面结合具体实施方式作进一步的说明。
具体实施方式
本发明中,纳米纤维丝可以木浆(纤维素含量90%)为原料,采用TEMPO氧化法制备得到,当然,也可直接从市面购买,多酚类化合物为单宁酸或多巴胺,直接从市面购买。
实施例1
制备0.3wt%纳米纤维丝水分散液,随后,将单宁酸水分散液滴入纳米纤维丝水分散液中,滴入单宁酸的质量占纳米纤维丝的2.5%。室温搅拌6-12h,得到均匀混合溶液;取10ml的均匀混合溶液,置于抽滤杯(带聚四氟乙烯滤膜)中真空抽滤,自然干燥6h,小心从聚四氟乙烯滤膜上揭下,再经牵伸、水洗、自然干燥6h,获得厚度为10μm的滤蛋白阻菌中空纤维膜。
实施例2
制备4wt%纳米纤维丝水分散液,随后,将单宁酸水分散液滴入纳米纤维丝水分散液中,滴入单宁酸的质量占纳米纤维丝的10%。室温搅拌6-12h,得到均匀混合溶液;取10ml的均匀混合溶液,置于抽滤杯(带聚四氟乙烯滤膜)中真空抽滤,自然干燥7h,小心从聚四氟乙烯滤膜上揭下,再经牵伸、水洗、自然干燥7h,获得厚度为20μm的滤蛋白阻菌中空纤维膜。
实施例3
制备8wt%纳米纤维丝水分散液,随后,将单宁酸水分散液滴入纳米纤维丝水分散液中,滴入单宁酸的质量占纳米纤维丝的15%。室温搅拌6-12h,得到均匀混合溶液;取10ml的均匀混合溶液,置于抽滤杯(带聚四氟乙烯滤膜)中真空抽滤,自然干燥8h,小心从聚四氟乙烯滤膜上揭下,再经牵伸、水洗、自然干燥8h,获得厚度为30μm的滤蛋白阻菌中空纤维膜。
实施例4
将实施例1-3制备得到的滤蛋白阻菌中空纤维膜分别作为膜组件,取小鼠血液依次穿过这些膜组件,其小鼠血液可完全穿过,无成分损失,且各膜组件可显著抵抗大肠杆菌和金黄色葡萄球菌。
Claims (9)
1.一种滤蛋白阻菌中空纤维膜,其特征在于,包括纳米纤维丝、多酚类化合物,通过氢键结合构成均一的膜状结构。
2.根据权利要求1所述的滤蛋白阻菌中空纤维膜,其特征在于,纳米纤维丝的长度为20-100μm,纳米纤维丝和多酚类化合物的质量比为100:2.5-15。
3.根据权利要求1所述的滤蛋白阻菌中空纤维膜,其特征在于,所述膜状结构的厚度为10-30μm。
4.根据权利要求1所述的滤蛋白阻菌中空纤维膜,其特征在于,所述多酚类化合物为单宁酸或多巴胺。
5.权利要求1-4任一滤蛋白阻菌中空纤维素的制备方法,其特征在于,包括如下步骤:
1)取纳米纤维丝、多酚类化合物,分别制备为纳米纤维丝分散液、多酚类化合物分散液;
2)将多酚类化合物分散液滴加至纳米纤维丝分散液中,且搅拌,得到混合液;
3)混合液经抽滤、干燥,得到初级膜;
4)初级膜经牵伸、水洗、干燥,得到目标产品。
6.根据权利要求5所述的制备方法,其特征在于,步骤1)采用水作为分散剂,纳米纤维丝分散液的浓度为0.3-8wt%。
7.根据权利要求5所述的制备方法,其特征在于,步骤3)所述干燥,为自然阴干,干燥时间为6-8h。
8.根据权利要求5所述的制备方法,其特征在于,步骤4)所述干燥,为自然阴干,干燥时间为6-8h。
9.权利要求1-4任一滤蛋白阻菌中空纤维膜在用于制备血液膜组件中的用途。
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