CN114557940A - Anti-pollution sunscreen composition, anti-pollution sunscreen skin care composition and preparation method thereof - Google Patents
Anti-pollution sunscreen composition, anti-pollution sunscreen skin care composition and preparation method thereof Download PDFInfo
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- CN114557940A CN114557940A CN202210187644.0A CN202210187644A CN114557940A CN 114557940 A CN114557940 A CN 114557940A CN 202210187644 A CN202210187644 A CN 202210187644A CN 114557940 A CN114557940 A CN 114557940A
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- 208000017983 photosensitivity disease Diseases 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention belongs to the technical field of anti-pollution sunscreen compositions, and particularly relates to an anti-pollution sunscreen composition, an anti-pollution sunscreen skin care composition and a preparation method thereof. The components of the anti-pollution sunscreen composition comprise exopolysaccharide, thiotaurine, aloe extract, scutellaria baicalensis extract, polyhydric alcohol and water; the components of the anti-pollution sunscreen skin care composition comprise a water-in-oil surfactant, a sunscreen agent, an oil phase, an anti-pollution sunscreen composition and a humectant; the anti-pollution sunscreen composition disclosed by the invention fully exerts the synergistic effect of each component by combining the anti-pollution sunscreen mechanism, achieves a good anti-pollution sunscreen effect, and has no adverse reaction on skin.
Description
Technical Field
The invention belongs to the technical field of anti-pollution sunscreen compositions, and particularly relates to an anti-pollution sunscreen composition, an anti-pollution sunscreen skin care composition and a preparation method thereof.
Background
PM2.5(particulate matter) refers to fine particles with an aerodynamic equivalent diameter of less than or equal to 2.5 μm, and is an important pollutant of the atmosphere at present. The skin, which acts as a barrier to the human body, is the organ with the largest area exposed to air and is most vulnerable to injury. PM2.5 causes a series of problems such as allergic dermatosis, skin aging, pigmentation and the like, and aggravates skin diseases such as atopic dermatitis, eczema and the like. Air pollution affects the skin mainly through four aspects: ozone in the air reacts with vitamin E and vitamin C in the skin to reduce the content of vitamin E and vitamin C in the skin, thereby increasing oxidative stress; polycyclic aromatic hydrocarbons in automobile exhaust cause damage to DNA, affect antioxidant enzymes, cause cytotoxicity and apoptosis; the heavy metal inhibits the synthesis of antioxidant enzyme and inhibits the function of enzyme; the dust causes skin inflammation, increases skin sensitivity and blocks pores.
When people are exposed to outdoor activities, the skin is not only exposed to uv light, but also attacked by PM2.5 and other harmful chemical particles. Ultraviolet rays can cause direct damage to the skin, including direct damage to cellular DNA, and killing of cells through phototoxic effects, as well as indirect damage to the skin, including induction of inflammation, free radicals, formation of immunosuppression, and the like. Therefore, it is necessary to develop a sunscreen cosmetic having both excellent sunscreen effect and anti-pollution effect.
The currently available anti-fouling products have the following disadvantages: the function is single, the physical barrier is mainly used, and the film forming effect is difficult to ensure. Based on the consideration of actual use environment, the sun-proof mechanism and the anti-pollution mechanism are combined to develop a composition, so that the sun-proof mechanism and the anti-pollution mechanism complement each other, the actual use effect is improved, and the formula cost is reduced.
Disclosure of Invention
In view of the above problems, the present invention aims to provide an anti-pollution sunscreen composition, an anti-pollution sunscreen skin care composition and a preparation method thereof, which combine the anti-pollution sunscreen mechanism to fully exert the synergistic effect of each component to achieve a good anti-pollution sunscreen effect.
The technical content of the invention is as follows:
the invention provides an anti-pollution sunscreen composition, which comprises the components of exopolysaccharide, thiotaurine, aloe extract, scutellaria baicalensis extract, polyalcohol and water;
according to the weight portion, in the composition, the extracellular polysaccharide accounts for 0.01-5 portions, the thiotaurine accounts for 0.01-5 portions, the aloe extract accounts for 0.1-10 portions, the scutellaria baicalensis extract accounts for 0.1-10 portions, the polyalcohol accounts for 40-60 portions, and water is supplemented to 100 portions;
the polyol comprises butanediol.
The invention also provides the anti-pollution sunscreen composition applied to skin care products, including skin care cream and sunscreen cream, and the anti-pollution sunscreen composition has anti-pollution and sunscreen effects.
The invention also provides an anti-pollution sunscreen skin care composition, which comprises the components of a water-in-oil surfactant, a sunscreen agent, an oil phase, an anti-pollution sunscreen composition and a humectant;
the water-in-oil surfactant comprises one or more of cetyl PEG/PPG-10/1 polydimethylsiloxane, lauryl PEG-8 polydimethylsiloxane, lauryl PEG-10 tris (trimethylsiloxy) silylethyl polydimethylsiloxane, laureth-4 and SSG-210 SP;
the sunscreen agent comprises one or more of ethylhexyl methoxycinnamate, diethyl aminooxybenzoyl hexyl benzoate, octocrylene, bis-ethylhexyloxyphenol methoxyphenyl triazine, butyl methoxydibenzoyl methane, and polysiloxane-15
The oil phase comprises an emollient and a skin conditioning agent, wherein the emollient comprises one or a combination of more than two of isohexadecane, cyclopenta dimethyl siloxane, isononyl isononanoate, C12-15 alcohol benzoate, dioctyl carbonate and polyhydroxystearic acid;
the humectant comprises one or the combination of more than two of glycerin, butanediol and glycerol polyether-26;
the anti-pollution sunscreen skin care composition comprises the following components:
phase A: 0-23 parts of an emollient, 0-4 parts of a water-in-oil surfactant, 0-6 parts of zinc oxide and triethoxy octyl silane, 0-3 parts of titanium dioxide, aluminum hydroxide and stearic acid, 0-0.5 part of quaternary ammonium salt-18 bentonite and 0-0.5 part of tocopheryl acetate;
phase B: 0.01-0.1 part of EDTA disodium, 0-15 parts of humectant, 0.01-0.2 part of preservative, 0-1 part of sodium chloride and water to make up to 100 parts;
and C phase: 0.01-5 parts of an emollient, 9-32 parts of a sun-screening agent and 0.01-0.2 part of a preservative;
phase D: 0.1-10 parts of an anti-pollution sunscreen composition;
phase E: 0-5 parts of ethanol, 0.1-1.0 part of preservative and 0.01-0.1 part of essence.
The preparation method of the anti-pollution sunscreen skin care composition comprises the following steps:
1) respectively mixing the components of the phases A to E, and uniformly stirring and homogenizing;
2) respectively heating the phase B and the phase C at 80-85 ℃, and preserving heat;
3) adding phase A and phase C into emulsifying pot, stirring, homogenizing, slowly adding phase B into A, C phase mixed solution while stirring, and homogenizing for 3 min;
4) cooling to 40-45 ℃, adding the phase D into the A, B, C phase mixed solution, stirring uniformly, and keeping the temperature;
5) and adding the phase E, and stirring and homogenizing uniformly to obtain the anti-pollution sunscreen skin care composition.
The invention has the following beneficial effects:
according to the anti-pollution sunscreen composition, the adopted extracellular polysaccharide contains polymeric anions, has quite a large number of negative charges, can be combined with pollutants with positive charges to prevent pollutants from adsorbing human healthy cells, has biological activity of removing free radicals, can remove oxygen free radicals in the air, and can complex metal ions in the air, so that the generation of active oxygen is inhibited; the adopted thiotaurine inhibits the DNA damage of the polycyclic aromatic hydrocarbon to the fibroblasts, promotes the proliferation of the cells and can well remove free radicals generated by the polycyclic aromatic hydrocarbon; aloe contains more than 70 kinds of substances beneficial to human body, and has effects of absorbing ultraviolet, polysaccharide component in the adopted Aloe extract has effect of enhancing immunity, and emodin and aloin in Aloe have effects of resisting oxidation and scavenging free radicals; the adopted scutellaria baicalensis extract is rich in baicalin and baicalein, and is also a plant-derived ultraviolet absorbent, the scutellaria baicalensis extract can effectively protect the skin from being damaged by ultraviolet rays by reducing free radicals generated by illumination, the scutellaria baicalensis extract has the biological activities of obvious inflammation resistance, immune regulation, allergic reaction resistance and the like, excessive oxygen radicals caused by external factors such as air pollution and the like, and has the effects of delaying photoaging, preventing sunburn, inhibiting the generation of sunburn erythema and the like;
the anti-pollution sunscreen composition disclosed by the invention fully exerts the synergistic effect of each component by combining the anti-pollution sunscreen mechanism, achieves a good anti-pollution sunscreen effect, and has no adverse reaction on the skin.
Detailed Description
The present invention is described in further detail in the following detailed description with reference to specific embodiments, which are intended to be illustrative only and not to be limiting of the scope of the invention, as various equivalent modifications of the invention will become apparent to those skilled in the art after reading the present invention and are intended to be included within the scope of the appended claims.
All the raw materials and reagents of the invention are conventional market raw materials and reagents unless otherwise specified.
Example 1
Anti-pollution sunscreen skin care composition
Phase A: 7 parts of isohexadecane, 12.5 parts of cyclopenta dimethyl silicone polymer, 3 parts of cetyl PEG/PPG-10/1 dimethyl silicone polymer, 6 parts of zinc oxide and triethoxy octyl silane, 3 parts of titanium dioxide, aluminum hydroxide and stearic acid, 0.2 part of quaternary ammonium salt-18 bentonite and 0.5 part of tocopherol acetate;
phase B: 0.1 part of EDTA disodium, 0.2 part of glycerol polyether-263, 0.5 part of methyl hydroxybenzoate, 0.5 part of sodium chloride and 33.3 parts of water;
and C phase: 5 parts of isononyl isononanoate, 7 parts of ethylhexyl methoxycinnamate, 3 parts of diethyl amino hydroxybenzoyl hexyl benzoate, 5 parts of octocrylene, 1 part of bis-ethylhexyloxyphenol methoxyphenyl triazine and 0.1 part of propyl hydroxybenzoate;
phase D: 5 parts of anti-pollution sun-screening composition;
in the anti-pollution sunscreen composition, 3 parts of exopolysaccharide, 5 parts of thiotaurine, 4 parts of aloe extract, 3 parts of scutellaria extract, 50 parts of butanediol and 35 parts of water;
phase E: 4 parts of ethanol, 0.5 part of phenoxyethanol and 0.1 part of daily essence.
The preparation method comprises the following steps:
1) respectively mixing the components of the phases A to E, and uniformly stirring and homogenizing;
2) respectively heating the phase B and the phase C at 83 ℃, and preserving heat;
3) adding phase A and phase C into emulsifying pot, stirring, homogenizing, slowly adding phase B into A, C phase mixed solution while stirring, and homogenizing for 3 min;
4) cooling to 42 ℃, adding the phase D into the A, B, C phase mixed solution, stirring uniformly, and keeping the temperature;
5) and adding the phase E, and stirring and homogenizing uniformly to obtain the anti-pollution sunscreen skin care composition.
Example 2
Anti-pollution sunscreen skin care composition
Phase A: 7 parts of isohexadecane, 12.5 parts of cyclopentasiloxane, 3 parts of cetyl PEG/PPG-10/1 polydimethylsiloxane, 6 parts of zinc oxide and triethoxyoctylsilane, 3 parts of titanium dioxide, aluminum hydroxide and stearic acid, 0.2 part of quaternary ammonium salt-18 bentonite and 0.5 part of tocopherol acetate;
phase B: 0.1 part of EDTA disodium, 261 parts of glycerol polyether, 0.2 part of methyl hydroxybenzoate, 0.5 part of sodium chloride and 38.1 parts of water;
and C phase: 5 parts of isononyl isononanoate, 7 parts of ethylhexyl methoxycinnamate, 3 parts of diethyl amino hydroxybenzoyl hexyl benzoate, 5 parts of octocrylene, 1 part of bis-ethylhexyloxyphenol methoxyphenyl triazine and 0.1 part of propyl hydroxybenzoate;
phase D: 1 part of anti-pollution sun-screening composition;
in the anti-pollution sunscreen composition, 3 parts of extracellular polysaccharide, 5 parts of thiotaurine, 4 parts of aloe extract, 3 parts of scutellaria extract, 50 parts of butanediol and 35 parts of water are added;
phase E: 4 parts of ethanol, 0.5 part of phenoxyethanol and 0.1 part of daily essence.
The preparation method comprises the following steps:
1) respectively mixing the components of the phases A to E, and uniformly stirring and homogenizing;
2) respectively heating the phase B and the phase C at 83 ℃, and preserving heat;
3) adding phase A and phase C into emulsifying pot, stirring, homogenizing, slowly adding phase B into A, C phase mixed solution while stirring, and homogenizing for 3 min;
4) cooling to 42 ℃, adding the phase D into the A, B, C phase mixed solution, stirring uniformly, and keeping the temperature;
5) and adding the phase E, and stirring and homogenizing uniformly to obtain the anti-pollution sunscreen skin care composition.
Example 3
Anti-pollution sunscreen skin care composition
Phase A: 8 parts of isohexadecane, 8 parts of C12-15 alcohol benzoate, 1 part of polyhydroxystearic acid, 2 parts of lauryl PEG-10 tris (trimethylsiloxy) silylethyl polydimethylsiloxane, 1 part of SSG-210SP, 5 parts of zinc oxide and triethoxyoctylsilane, 2 parts of titanium dioxide, aluminum hydroxide and stearic acid, 0.5 part of quaternary ammonium salt-18 bentonite and 0.3 part of tocopherol acetate;
phase B: 0.01 part of EDTA disodium, 5 parts of butanediol, 262 parts of glycerol polyether, 0.2 part of methyl hydroxybenzoate, 1 part of sodium chloride and 33.09 parts of water;
and C phase: 2 parts of dioctyl carbonate, 4 parts of ethylhexyl methoxycinnamate, 4 parts of diethyl aminohydroxybenzoyl hexyl benzoate, 4 parts of octocrylene, 3 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine and 0.2 part of propyl hydroxybenzoate;
phase D: 10 parts of anti-pollution sun-screening composition;
in the anti-pollution sunscreen composition, 5 parts of exopolysaccharide, 2 parts of thiotaurine, 10 parts of aloe extract, 10 parts of scutellaria extract, 40 parts of butanediol and 33 parts of water;
phase E: 2 parts of ethanol, 0.6 part of phenoxyethanol and 0.1 part of daily essence.
The preparation method comprises the following steps:
1) respectively mixing the components of the phases A to E, and uniformly stirring and homogenizing;
2) respectively heating the phase B and the phase C at 85 ℃, and preserving heat;
3) adding phase A and phase C into emulsifying pot, stirring, homogenizing, slowly adding phase B into A, C phase mixed solution while stirring, and homogenizing for 3 min;
4) cooling to 45 ℃, adding the phase D into the A, B, C phase mixed solution, stirring uniformly, and keeping the temperature;
5) and adding the phase E, and stirring and homogenizing uniformly to obtain the anti-pollution sunscreen skin care composition.
Example 4
Anti-pollution sunscreen skin care composition
Phase A: 3 parts of C12-15 alcohol benzoate, 8 parts of dioctyl carbonate, 2 parts of lauryl PEG-8 polydimethylsiloxane, 2 parts of lauryl PEG-10 tri (trimethylsiloxy) silyl ethyl polydimethylsiloxane, 6 parts of zinc oxide and triethoxyoctylsilane, 3 parts of titanium dioxide, aluminum hydroxide and stearic acid, 0.2 part of quaternary ammonium salt-18 bentonite, 1 part of cyclopentadimethylsiloxane and 0.5 part of tocopherol acetate;
phase B: 0.2 part of EDTA disodium, 5 parts of glycerol, 3 parts of butanediol, 0.05 part of methyl hydroxybenzoate, 0.5 part of sodium chloride and 34 parts of water;
and C phase: 5 parts of C12-15 alcohol benzoate, 7 parts of ethylhexyl methoxycinnamate, 3 parts of octocrylene, 3 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 153 parts of polysiloxane and 0.05 part of propyl hydroxybenzoate;
phase D: 7 parts of an anti-pollution sunscreen composition;
in the anti-pollution sunscreen composition, 2 parts of exopolysaccharide, 2 parts of thiotaurine, 3 parts of aloe extract, 3 parts of scutellaria extract, 60 parts of butanediol and 30 parts of water;
phase E: 2.5 parts of ethanol, 0.9 part of phenoxyethanol and 0.1 part of daily essence.
The preparation method comprises the following steps:
1) respectively mixing the components of the phases A to E, and uniformly stirring and homogenizing;
2) respectively heating the phase B and the phase C at 80 ℃, and preserving heat;
3) adding phase A and phase C into emulsifying pot, stirring, homogenizing, slowly adding phase B into A, C phase mixed solution while stirring, and homogenizing for 3 min;
4) cooling to 40 ℃, adding the phase D into the A, B, C phase mixed solution, stirring uniformly, and keeping the temperature;
5) and adding the phase E, and stirring and homogenizing uniformly to obtain the anti-pollution sunscreen skin care composition.
Comparative example 1
Anti-pollution sunscreen skin care composition
Phase A, phase B and phase C are the same as in example 1;
phase D: 5 parts of anti-pollution sun-screening composition;
in the anti-pollution sunscreen composition, 2 parts of extracellular polysaccharide, 3 parts of thiotaurine, 50 parts of butanediol and 45 parts of water;
phase E: 4 parts of ethanol, 0.5 part of phenoxyethanol and 0.1 part of daily essence.
The preparation method is the same as that of example 1.
Comparative example 2
Anti-pollution sunscreen skin care composition
Phase A, phase B and phase C are the same as in example 1;
phase D: 5 parts of an anti-pollution sunscreen composition;
in the anti-pollution sunscreen composition, 3 parts of extracellular polysaccharide, 5 parts of thiotaurine, 4 parts of aloe extract, 3 parts of scutellaria extract, 50 parts of butanediol and 35 parts of water are added;
phase E: 4 parts of ethanol, 0.5 part of phenoxyethanol and 0.1 part of daily essence.
The preparation method is the same as that of example 1.
Comparative example 3
Anti-pollution sunscreen skin care composition
Phase a, phase B, phase C, phase E are the same as in example 1, and phase D (anti-fouling sunscreen composition) is not added, and is prepared in the same manner as in example 1.
The examples and the anti-pollution sunscreen skin care composition prepared in comparative example 1 were subjected to the following relevant tests.
1. Test of patch Effect
The test method comprises the following steps: according to the seventh chapter of human safety inspection methods in the cosmetic safety technical Specification 2015, the sunscreen compositions of examples 1-4 and comparative examples 1-3 were respectively selected for open patch experiments.
TABLE 1 Patch test results
As can be seen from Table 1, in comparative example 3, there were 2 suspected reactions in the subject, 1 weakly positive reaction (erythema), and all subjects had no response to the sunscreen compositions of examples 1-3. It can be seen that the application of mild, non-burdening and anti-fouling sunscreen composition systems has higher safety and lower skin irritation.
2. Test of anti-pollution Effect
2.1 anti-inflammatory Capacity test:
the environmental pollution can trigger the inflammatory reaction of skin, and NF-kb (transcription factor) is known to be a main regulatory protein in the inflammatory reaction of the body and controls the production and release of various inflammatory protein factors. Many actives exert anti-inflammatory effects by inhibiting NF-kb. NF-kb is used as an inflammation marker, and inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) or interleukin and the like are used for stimulating human keratinocytes, activating the NF-kb and inducing cell inflammation reaction. The cells were treated with a certain concentration of the samples of examples 1 to 4 of the present invention and comparative examples 1 to 3, and their ability to inhibit NF-kb expression was observed.
The specific test mode is as follows: 10 volunteers aged 20-50 are selected from each experimental group, and all the volunteers live in large cities, are affected by deep pollution and have rough and dark skin; the using method comprises the following steps: about 2 grams of the samples of inventive examples 1-4 and comparative examples 1-3 were applied to the face once a day. And taking pictures and archiving after 1 month. The results of comparing examples 1-4 with comparative examples 1-3, the percent inhibition of the inflammatory response of the cells by the agent was obtained and are shown in Table 2.
TABLE 2 inhibition of NF-kb by the anti-fouling sunscreen skin care composition
2.2 Spot Effect test
The PM particles floating in the air are only one-fiftieth of the diameter of pores and easily enter the pores, and the PM particles contain chemical components and seriously damage the stratum corneum renewal cycle and rate, causing a series of skin problems. Such as dull skin tone, yellow skin tone, rough skin, increased spots, etc. Observed using a VISIA tester.
The specific test mode is as follows: 10 volunteers are selected from each experimental group, are healthy, have no skin disease or allergic disease history, are non-sensitive to skin, can use cosmetics according to a range, are matched with workers to complete evaluation work according to requirements, have certain expression capability, and can truly reflect the feeling after use. About 2 grams of the samples of inventive examples 1-4 and comparative examples 1-3 were applied to the face once a day for 1 month, and the data on day 0 and day 30 were compared as shown in Table 3.
TABLE 3 reduction of stain resistance of sunscreen skin care compositions
From the above anti-inflammatory ability test and the two-spot effect test, it can be seen from tables 2 and 3 that example 3 has a higher NF-kb inhibition ratio and a higher mottle reduction ratio than examples 1, 2 and 4, and it is a preferred example of the present invention that the content ratio of each component in example 3 is an optimal ratio. As can be seen from comparison of examples 1 to 4 with comparative examples 1 to 3, the effect is the best when the components of the anti-pollution composition of the invention are used together, which shows that the components of the anti-pollution composition of the invention have synergistic effect. The extracellular polysaccharide and the traditional Chinese medicine composition are added in the anti-pollution combination, so that the anti-pollution performance and the anti-allergy performance are enhanced, the product performance of the anti-pollution combination is improved, the anti-pollution combination has higher performance than other products of the same type, and the anti-pollution combination has the effect of resisting air pollution.
As can be seen from the above table, comparative examples 2 and 3 have no anti-pollution effect, comparative example 1 has slight anti-pollution effect, and examples have good anti-pollution effect, and thus, the anti-pollution sunscreen composition of the present invention has good anti-pollution effect.
3. In vivo determination of Sun Protection Factor (SPF)
The Sun Protection Factor (SPF) of sunscreen cosmetics was determined as specified in the 2007 edition of the cosmetic hygiene Specification, and the SPF value was calculated according to the formula SPF ═ H1/H2.
H1 is the minimum erythema dose to protect skin with sunscreen cosmetics; h2 is the minimum erythema dose of unprotected skin; the minimum erythema dose is the minimum dose (J/m) of ultraviolet irradiation required to cause erythema of the skin in the range of reaching the edge of the irradiated spot2)。
The test subjects are 15 healthy volunteer subjects aged 18-35, no history of the prior photosensitivity disease exists, no medicine influencing the photosensitivity is used in the recent time, and the test results are averaged.
TABLE 4 Sun protection index of anti-fouling sunscreen skin care compositions
As can be seen from table 4, compared with the comparative ratio, the anti-pollution sunscreen skin care composition prepared by the embodiment of the present invention has a good synergistic effect on the sun protection index.
Claims (10)
1. An anti-pollution sunscreen composition, which is characterized by comprising components of exopolysaccharide, thiotaurine, aloe extract, scutellaria baicalensis extract, polyhydric alcohol and water.
2. The anti-pollution sunscreen composition of claim 1, wherein the composition comprises 0.01 to 5 parts by weight of exopolysaccharide, 0.01 to 5 parts by weight of thiotaurine, 0.1 to 10 parts by weight of aloe vera extract, 0.1 to 10 parts by weight of scutellaria baicalensis extract, 40 to 60 parts by weight of polyhydric alcohol, and water to make up to 100 parts by weight.
3. An anti-pollution sunscreen composition as defined in claim 1 or 2 applied to skin care products including skin care cream, sun protection cream.
4. An anti-pollution sunscreen skin care composition characterized in that the components of the anti-pollution sunscreen skin care composition comprise a water-in-oil surfactant, a sunscreen, an oil phase, the anti-pollution sunscreen composition of claim 1 or 2, and a humectant.
5. The anti-stain sunscreen skin care composition of claim 4 wherein the water-in-oil surfactant comprises one or a combination of two or more of cetyl PEG/PPG-10/1 dimethicone, lauryl PEG-8 dimethicone, lauryl PEG-10 tris (trimethylsiloxy) silylethyl dimethicone, laureth-4, SSG-210 SP.
6. The anti-contaminant, sunscreen skin care composition of claim 4 wherein said sunscreen comprises one or a combination of two or more of ethylhexyl methoxycinnamate, hexyl diethylamino hydroxybenzoyl benzoate, octocrylene, bis-ethylhexyloxyphenol methoxyphenyl triazine, butyl methoxydibenzoylmethane, polysiloxane-15.
7. The anti-pollution sunscreen skin care composition of claim 4 wherein the oil phase comprises an emollient and a skin conditioning agent, the emollient comprising one or a combination of two or more of isohexadecane, cyclopentadimethylsiloxane, isononyl isononanoate, C12-15 alcohol benzoate, dioctyl carbonate, polyhydroxystearic acid.
8. The anti-contaminant, sunscreen skin care composition according to claim 4 wherein the humectant comprises one or a combination of two or more of glycerin, butylene glycol, glyceryl polyether-26.
9. The anti-pollution sunscreen skin care composition of claim 4, wherein said anti-pollution sunscreen skin care composition comprises:
phase A: 0-23 parts of an emollient, 0-4 parts of a water-in-oil surfactant, 0-6 parts of zinc oxide and triethoxyoctylsilane, 0-3 parts of titanium dioxide, aluminum hydroxide and stearic acid, 0-0.5 part of quaternary ammonium salt-18 bentonite and 0-0.5 part of tocopherol acetate;
phase B: 0.01-0.1 part of EDTA disodium, 0-15 parts of humectant, 0.01-0.2 part of preservative, 0-1 part of sodium chloride and water to make up to 100 parts;
and C phase: 0.01-5 parts of an emollient, 9-32 parts of a sun-screening agent and 0.01-0.2 part of a preservative;
phase D: 0.1-10 parts of an anti-pollution sunscreen composition;
phase E: 0-5 parts of ethanol, 0.1-1.0 part of preservative and 0.01-0.1 part of essence.
10. A method for preparing an anti-pollution sunscreen skin care composition as defined in any one of claims 4 to 9, comprising the steps of:
1) respectively mixing the components of the phases A to E, and uniformly stirring and homogenizing;
2) respectively heating the phase B and the phase C at 80-85 ℃, and preserving heat;
3) adding phase A and phase C into emulsifying pot, stirring, homogenizing, slowly adding phase B into A, C phase mixed solution while stirring, and homogenizing for 3 min;
4) cooling to 40-45 ℃, adding the phase D into the A, B, C phase mixed solution, stirring uniformly, and keeping the temperature;
5) and adding the phase E, and stirring and homogenizing uniformly to obtain the anti-pollution sunscreen skin care composition.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116211745A (en) * | 2022-12-28 | 2023-06-06 | 妙梵医药科技(广州)有限公司 | Mild and non-irritating composition with sun-screening effect and preparation method thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5571503A (en) * | 1995-08-01 | 1996-11-05 | Mausner; Jack | Anti-pollution cosmetic composition |
CN102083408A (en) * | 2008-04-15 | 2011-06-01 | 创新公司 | Cosmetic compositions comprising exopolysaccharides derived from microbial mats, and use thereof |
CN102228418A (en) * | 2011-06-28 | 2011-11-02 | 云南龙润茶业集团有限公司 | Cosmetic for keeping skin health and beauty and preparation method thereof |
JP2011256292A (en) * | 2010-06-10 | 2011-12-22 | Shiseido Co Ltd | Application of ufenamate, and skin care composition for ultraviolet protection blending the same |
CN111991258A (en) * | 2020-10-12 | 2020-11-27 | 上海辉文生物技术股份有限公司 | Skin detoxification and oxidation resistance composition and application thereof |
CN112512641A (en) * | 2018-05-31 | 2021-03-16 | 比奥尼克莱公司 | Method for the local protection of molecules of free radicals and/or atmospheric pollutants generated by exposure to ultraviolet radiation |
-
2022
- 2022-02-28 CN CN202210187644.0A patent/CN114557940A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5571503A (en) * | 1995-08-01 | 1996-11-05 | Mausner; Jack | Anti-pollution cosmetic composition |
CN102083408A (en) * | 2008-04-15 | 2011-06-01 | 创新公司 | Cosmetic compositions comprising exopolysaccharides derived from microbial mats, and use thereof |
JP2011256292A (en) * | 2010-06-10 | 2011-12-22 | Shiseido Co Ltd | Application of ufenamate, and skin care composition for ultraviolet protection blending the same |
CN102228418A (en) * | 2011-06-28 | 2011-11-02 | 云南龙润茶业集团有限公司 | Cosmetic for keeping skin health and beauty and preparation method thereof |
CN112512641A (en) * | 2018-05-31 | 2021-03-16 | 比奥尼克莱公司 | Method for the local protection of molecules of free radicals and/or atmospheric pollutants generated by exposure to ultraviolet radiation |
CN111991258A (en) * | 2020-10-12 | 2020-11-27 | 上海辉文生物技术股份有限公司 | Skin detoxification and oxidation resistance composition and application thereof |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116211745A (en) * | 2022-12-28 | 2023-06-06 | 妙梵医药科技(广州)有限公司 | Mild and non-irritating composition with sun-screening effect and preparation method thereof |
CN116211745B (en) * | 2022-12-28 | 2023-12-01 | 妙梵医药科技(广州)有限公司 | Mild and non-irritating composition with sun-screening effect and preparation method thereof |
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