CN114486789A - Method for constructing fingerprint spectrum of pearl layer powder hydrogel patch and fingerprint spectrum thereof - Google Patents
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- 239000000843 powder Substances 0.000 title claims abstract description 106
- 239000000017 hydrogel Substances 0.000 title claims abstract description 80
- 238000001228 spectrum Methods 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title claims abstract description 26
- 125000000524 functional group Chemical group 0.000 claims abstract description 9
- 238000007621 cluster analysis Methods 0.000 claims abstract description 7
- 238000010276 construction Methods 0.000 claims abstract description 4
- 238000001157 Fourier transform infrared spectrum Methods 0.000 claims description 9
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 8
- 238000010521 absorption reaction Methods 0.000 claims description 8
- 238000005102 attenuated total reflection Methods 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- 238000007619 statistical method Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000005452 bending Methods 0.000 claims description 3
- 238000003908 quality control method Methods 0.000 claims description 3
- -1 Carbonate ions Chemical class 0.000 claims description 2
- 238000004566 IR spectroscopy Methods 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 2
- 238000012795 verification Methods 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 abstract description 13
- 238000000513 principal component analysis Methods 0.000 abstract description 11
- 238000001514 detection method Methods 0.000 abstract description 3
- 239000011049 pearl Substances 0.000 description 57
- 238000004458 analytical method Methods 0.000 description 10
- 238000001816 cooling Methods 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000003814 drug Substances 0.000 description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 3
- 238000004220 aggregation Methods 0.000 description 3
- 238000002329 infrared spectrum Methods 0.000 description 3
- 229940041616 menthol Drugs 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 235000021419 vinegar Nutrition 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000002091 Febrile Seizures Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 241000490567 Pinctada Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 206010016284 febrile convulsion Diseases 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 231100000304 hepatotoxicity Toxicity 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 238000000491 multivariate analysis Methods 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N2021/3595—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using FTIR
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Abstract
The invention relates to the technical field of patch detection, in particular to a fingerprint spectrum construction method and a fingerprint spectrum of a pearl layer powder hydrogel patch. The nacreous layer powder hydrogel patch constructed by the invention has a Fourier transform infrared fingerprint spectrum, can identify the raw nacreous layer powder through characteristic functional groups, adopts principal component analysis and cluster analysis to identify the nacreous layer powder hydrogel patch, and establishes a method which is quick, convenient and can effectively identify the nacreous layer powder hydrogel patch and control the quality. The pearl layer powder hydrogel patch can be obviously distinguished from a counterfeit product, the distance between species is long, and the obtained Fourier infrared fingerprint can carry out high-precision identification on the pearl layer powder hydrogel patch.
Description
Technical Field
The invention relates to the technical field of patch detection, in particular to a method for constructing a fingerprint spectrum of a pearl layer powder hydrogel patch and a fingerprint spectrum thereof.
Background
Exogenous fever is a common disease and frequently-encountered disease, most common in infant stage and the first in acute infectious diseases, western medicine mostly adopts non-steroidal drugs to defervesce, although the curative effect is definite, the body temperature is easy to rebound, certain liver and kidney toxicity exists, children are difficult to take the medicine, and the treatment is not matched, so that the external treatment defervesce method, in particular to the medical plaster for defervesce of children, is widely welcomed. The medical patch for children defervescing volatilizes excessive heat in a human body through vaporization of water in gel, thereby achieving the effect of reducing body temperature.
The sea area of China is vast, in recent years, marine medicine resources are rapidly developed, the Nanzhu industry becomes a supporting industry for marine economic development in the south China sea, people obtain pearls and pearl oyster meat, meanwhile, a large amount of shell resources are left, particularly, pearl layer powder is arranged on the inner layer of the shells, the pearl layer powder mainly has the curative effect of tranquilizing and allaying excitement, and the pearl layer powder hydrogel antipyretic patch has the effect of tranquilizing and allaying excitement and has a certain effect of preventing common febrile convulsion in children.
The hydrogel is a high-water-absorption high-water-retention material, menthol and a freshener in a formula are also main components for physical cooling, the menthol can generate a cooling effect, but the menthol can not be used in large quantities due to strong smell and strong stimulation to skin and mucous membrane tissues, so that the cooling performance of the cooling patch is greatly improved by adding the pearl layer powder for assisting in cooling, but a commercial product for preparing the cooling patch by adding the pearl layer powder and a method for controlling the quality of the pearl layer powder in the patch are not available in the market, and in order to prevent other cooling patches from being confused and unqualified in the adding amount of the pearl layer powder, an infrared fingerprint method is established for distinguishing whether the pearl layer powder is mixed in the cooling patch and controlling the quality of the pearl layer powder in the cooling patch.
Therefore, finding a method for constructing a fingerprint of a pearl layer powder hydrogel patch and using the method to distinguish whether the antipyretic patch is doped with the pearl layer powder and control the quality of the pearl layer powder is a problem which needs to be solved urgently at present.
Disclosure of Invention
In order to solve the technical problems in the prior art, the invention provides a method for constructing a fingerprint of a nacre powder hydrogel patch and a fingerprint thereof, which comprise the following steps:
a method for constructing a fingerprint spectrum of a pearl layer powder hydrogel patch comprises the following steps:
adopting Fourier transform attenuated total reflection infrared spectroscopy to construct fingerprint spectrum of nacreous layer powder hydrogel patch, and characterizing compound class by characteristic functional groups, 4000cm-1-600cm-1The main components in the pearl powder hydrogel patch are comprehensively characterized in the wave band.
Further, the specific wave number of the fingerprint is 1800cm-1-600cm-1Performing multivariate statistical analysis as variable, identifying the nacreous layer powder hydrogel patch, and performing cluster analysis for verification.
Further, the compound class is characterized by characteristic functional groups, wherein the compound is as follows: water, alcohol compounds and carbonate compounds.
Further, the patch matrix to be tested is arranged at the sample inlet of the ATF attenuated total reflection module.
Further, the acquisition parameters of the fourier transform infrared spectrum are as follows: the spectrum collection range is 4000cm-1-600cm-1Resolution of the spectrum 4cm-1The number of scanning times is 16.
The fingerprint of the pearl layer powder hydrogel patch is constructed by adopting the fingerprint construction method of the pearl layer powder hydrogel patch. Further, the infrared spectrum is 4000cm-1-600cm-1Has multiple common peaks, wherein the peak length is 3283cm-1Absorption peaks due to water molecules; 2936cm-1、2881cm-1Is an absorption peak caused by C-H, O-H; 1656cm-1、1564cm-1And 1408cm-1The carbonate ions are asymmetrically stretched; 1035cm-1Being carbonate ionsSymmetrically stretching; cm of-1Out-of-plane bending vibrations caused by carbonate ions.
The fingerprint construction method and the fingerprint of the pearl layer powder hydrogel patch are applied to identification and quality control of the pearl layer powder hydrogel patch.
The Fourier transform infrared spectrum is derived from frequency doubling and frequency combining absorption of the hydrogen-containing group vibration of the molecules of the substance to be detected, the information is rich, almost all the information of the hydrogen-containing group of the substance to be detected is contained, and the Fourier transform infrared spectrum (FTIR) analysis technology has the advantages of simple sample preparation, small measurement area, high detection sensitivity, no pollution to the environment and the like. In addition, the application of the attenuated total reflectance Accessory (ATR) infrared spectrum enables the analysis of micro-area components to be convenient and rapid, and the micro-area components can enter the sample to directly measure samples in various aggregation states without complex sample preparation. The analysis speed of the Fourier transform infrared spectrum technology is high, and the measurement of a single sample can be completed within a few seconds.
The student of Jiangquan and the like adopts the Fourier infrared technology to judge the wine age of the yellow wine, and finds that the yellow wine with different wine ages has more obvious clustering characteristics; many students such as women adopt the attenuated total reflection Fourier transform infrared technology to establish the fingerprint spectrums of the four major vinegars, and find that different vinegars have different clustering characteristics. In conclusion, the Fourier infrared technology can be used for quickly identifying various products, but the identification of the patch is only reported, the invention adopts the Fourier infrared technology to quickly and nondestructively identify the pearl layer powder hydrogel patch, establishes the infrared fingerprint spectrum thereof and provides a new technical method for identifying the quality monitoring of the pearl powder in the pearl layer powder hydrogel patch
The difference of the patch in terms of whether pearl powder is added or not and the addition amount of the pearl powder exists in the selection of materials of the patch, so that the patches of various brands are different. The hydrogel patch sold in the market at present does not have a sample with the content of added nacreous layer powder, the Fourier transform infrared spectrum technology is adopted to take the peak area of each functional group as the judgment basis, the fingerprint of the nacreous layer powder hydrogel patch is established at high precision, the principal component analysis is established through the Fourier transform fingerprint of the nacreous layer powder hydrogel patch, if the Fourier transform fingerprint data of the sample to be detected is led into the invention, the attribution condition of the sample to be detected can be observed in the principal component analysis diagram, and thus whether the nacreous layer powder information is contained or not is determined.
Clustering analysis of carbonate ions in the pearl layer powder hydrogel patch: in order to obtain the identification information from the mass data generated by the fingerprint spectrum to the maximum extent, a multivariate statistical analysis method is required to be used, the interpretation of variables among samples is simplified by a dimension reduction method, the internal structure of analysis data can be explored by adopting principal component analysis, the aggregation condition of the samples is reflected, a standard model is established, and the quality of the object to be detected is monitored.
The nacreous layer powder hydrogel patch constructed by the invention has a Fourier transform infrared fingerprint spectrum, can identify the raw nacreous layer powder through characteristic functional groups, adopts principal component analysis and cluster analysis to identify the nacreous layer powder hydrogel patch, and establishes a method which is quick, convenient and can effectively identify the nacreous layer powder hydrogel patch and control the quality.
Compared with the prior art, the invention has the technical effects that:
the method adopts Fourier transform infrared spectroscopy technology and takes the peak area of each functional group as a judgment basis, the fingerprint of the pearl layer powder hydrogel patch is established at high precision, the principal component analysis is established through the Fourier transform fingerprint of the pearl layer powder hydrogel patch, if the Fourier transform fingerprint data of the sample to be detected is introduced into the method, the attribution condition of the sample to be detected can be observed in the principal component analysis chart, and thus whether the sample contains the pearl layer powder information or not is determined. The nacreous layer powder hydrogel patch constructed by the invention has a Fourier transform infrared fingerprint spectrum, can identify the raw nacreous layer powder through characteristic functional groups, adopts principal component analysis and cluster analysis to identify the nacreous layer powder hydrogel patch, and establishes a method which is quick, convenient and can effectively identify the nacreous layer powder hydrogel patch and control the quality. The pearl layer powder hydrogel patch can be obviously distinguished from a counterfeit product, the distance between species is long, and the obtained Fourier infrared fingerprint can carry out high-precision identification on the pearl layer powder hydrogel patch.
Drawings
FIG. 1 is a Fourier transform infrared fingerprint of a nacreous layer powder hydrogel patch;
FIG. 2 is a Fourier transform infrared fingerprint chromatogram overlay image of a pearl layer powder hydrogel patch;
FIG. 3 is a Fourier transform infrared spectrum of a hydrogel patch without added nacre powder;
FIG. 4 is a Fourier transform infrared spectrum overlay of a hydrogel patch without added nacreous layer powder;
FIG. 5 is a graph showing the results of principal component analysis of a pearl powder hydrogel patch sample and a patch sample without pearl powder;
FIG. 6 is a graph showing the results of OPLS-DA analysis of nacreous powder hydrogel patch samples and patch samples without nacreous powder;
FIG. 7 is a graph showing the results of cluster analysis of a pearl powder hydrogel patch sample and a patch sample without pearl powder.
Detailed Description
The technical solution of the present invention is further defined below with reference to the specific embodiments, but the scope of the claims is not limited to the description.
Example (b):
different batches of pearl layer powder hydrogel patch samples and patch samples without pearl layer powder are collected, the patch samples without pearl layer powder (Table 1) are respectively represented by A1, A2, A3, A4, A5, A6, A7, A8, A9 and A10, the 10 batches of pearl layer powder hydrogel patch samples (Table 2) are respectively represented by B1, B2, B3, B4, B5, B6, B7, B8, B9 and B10, and the related information of the pearl layer powder is specifically shown in Table 3. Placing the matrix of the patch to be tested at the sample inlet of ATF module, with spectrum collection range of 4000cm-1-600cm-1Resolution of the spectrum 4cm-1The number of scanning times is 16. Establishing fingerprint of nacreous layer powder hydrogel patch sample, identifying different patches by principal component analysis and cluster analysis, and determining specific wave number of the fingerprint 1800cm-1-600cm-1Multivariate statistics as variablesAnd (4) analyzing, namely identifying the pearl layer powder hydrogel patch, and verifying clustering analysis.
TABLE 1 hydrogel patch without pearl powder for different batches
TABLE 2 hydrogel patch of different batches of pearl powder
The hydrogel patch without pearl powder and the hydrogel patch with pearl powder are prepared by self, and only the difference of whether pearl powder is added exists, and the raw materials comprise the following components:
TABLE 3 detailed information of nacreous layer powder
The pearl layer powder hydrogel patch has Fourier transform infrared fingerprint spectrum:
the nacreous layer powder hydrogel patch has Fourier transform infrared fingerprint spectrum shown in figure 1.
The pearl layer powder hydrogel patch has a peak overlapping pattern of Fourier transform infrared fingerprint spectrum shown in figure 2.
The nacreous layer powder hydrogelThe patch has infrared spectrum of 4000cm-1-600cm-1Has multiple common peaks, wherein the peak length is 3283cm-1Absorption peaks due to water molecules; 2936cm-1、2881cm-1Is an absorption peak caused by C-H, O-H; 1656cm-1、1564cm-1And 1408cm-1The carbonate ions are asymmetrically stretched; 1035cm-1Carbonate ions are symmetrically stretched; 848cm-1Out-of-plane bending vibrations caused by carbonate ions.
And (3) analyzing the similarity of infrared spectrograms of the pearl layer powder hydrogel patch:
the collected 10 batches of nacre powder hydrogel patch samples are respectively represented by B1, B2, B3, B4, B5, B6, B7, B8, B9 and B10, the similarity is more than 0.98 (see Table 4 specifically), the similarity is higher, and the influence of the preparation process of each sample on the samples is small.
TABLE 4 nacreous layer powder hydrogel patch sample similarity
The hydrogel without pearl layer powder is pasted with a Fourier transform infrared fingerprint spectrum:
the Fourier transform infrared fingerprint of hydrogel patch without pearl powder is shown in FIG. 3.
The superposed peak image of Fourier transform infrared fingerprint spectrum of hydrogel patch without pearl powder is shown in FIG. 4.
Specific wave number 1800cm by fingerprint-1-600cm-1Performing multivariate statistical analysis as a variable, identifying the pearl layer powder hydrogel patch, and verifying clustering analysis:
the specific results are shown in FIGS. 5-7.
PCA principal component analysis is an unsupervised multivariate statistical analysis method, and as can be seen from the PCA result in FIG. 5, the two groups of samples are well separated, and the samples in the groups are well clustered; the OPLS-DA analysis is a supervised multivariate statistical analysis method, and the result in FIG. 6 shows that the samples between two groups are obviously clustered; in addition, clustering analysis is performed according to the similarity of the samples, and as can be seen from the clustering tree result in fig. 7, significant clustering exists between the samples in the groups a and B. From the results, the sample group of the nacre powder hydrogel patch has good aggregation degree, which indicates that the sample is reasonably and reliably selected and is representative. The pearl layer powder hydrogel patch and a counterfeit product can be obviously distinguished, the distance between species is far, and the fact that the pearl layer powder hydrogel patch can be identified with high precision by means of Fourier infrared fingerprint is shown.
Finally, it should be noted that the above embodiments are merely representative examples of the present invention. Obviously, the technical solution of the present invention is not limited to the above-described embodiments, and many variations are possible. All modifications which can be derived or suggested by a person skilled in the art from the disclosure of the present invention are to be considered within the scope of the invention.
Claims (9)
1. A method for constructing a fingerprint spectrum of a pearl layer powder hydrogel patch is characterized by comprising the following steps:
adopting Fourier transform attenuated total reflection infrared spectroscopy to construct fingerprint spectrum of nacreous layer powder hydrogel patch, and characterizing compound class by characteristic functional groups, 4000cm-1-600cm-1The main components in the pearl powder hydrogel patch are comprehensively characterized in the wave band.
2. The method for constructing a fingerprint of a hydrogel patch of nacre powder according to claim 1, wherein the specific wavenumber of the fingerprint is 1800cm-1-600cm-1Performing multivariate statistical analysis as variable, identifying the nacreous layer powder hydrogel patch, and performing cluster analysis for verification.
3. The method for constructing the fingerprint of the nacre powder hydrogel patch according to claim 1, wherein the compound is characterized by the characteristic functional groups, wherein the compound is: water, alcohol compounds and carbonate compounds.
4. The method for constructing a fingerprint of a nacre powder hydrogel patch according to claim 1, wherein the patch substrate to be tested is placed at a sample inlet of an ATF attenuated total reflectance module.
5. The method for constructing a fingerprint of a nacre powder hydrogel patch according to claim 1, wherein the parameters for acquiring the fourier transform infrared spectrum are: the spectrum collection range is 4000cm-1-600cm-1Resolution of the spectrum 4cm-1The number of scanning times is 16.
6. The pearl powder hydrogel patch fingerprint spectrum constructed by the pearl powder hydrogel patch fingerprint spectrum construction method of claim 1.
7. The nacre powder hydrogel patch of claim 6 having a fingerprint at 4000cm-1-600cm-1Has multiple common peaks, wherein the peak length is 3283cm-1Absorption peaks due to water molecules; 2936cm-1、2881cm-1Is an absorption peak caused by C-H, O-H; 1656cm-1、1564cm-1And 1408cm-1The carbonate ions are asymmetrically stretched; 1035cm-1Carbonate ions are symmetrically stretched; cm-1Out-of-plane bending vibrations caused by carbonate ions.
8. The method for constructing the nacre powder hydrogel patch by using the fingerprint spectrum as set forth in claim 1, and its application in identification and quality control of nacre powder hydrogel patch.
9. The nacre powder hydrogel patch fingerprint spectrum of claim 6, the application in identification and quality control of nacre powder hydrogel patch.
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| CN103411895A (en) * | 2013-08-23 | 2013-11-27 | 中国检验检疫科学研究院 | Near infrared spectrum identification method of adulteration of pearl powder |
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| CN103411895A (en) * | 2013-08-23 | 2013-11-27 | 中国检验检疫科学研究院 | Near infrared spectrum identification method of adulteration of pearl powder |
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