CN114480301B - 预防或治疗禽病毒感染症的疫苗 - Google Patents

预防或治疗禽病毒感染症的疫苗 Download PDF

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CN114480301B
CN114480301B CN202210072761.2A CN202210072761A CN114480301B CN 114480301 B CN114480301 B CN 114480301B CN 202210072761 A CN202210072761 A CN 202210072761A CN 114480301 B CN114480301 B CN 114480301B
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刘凤丽
曹艳欣
苏敬良
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China Agricultural University
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Abstract

本申请提供了一种鸭瘟病毒(又称鸭肠炎病毒)弱毒株DEV SD70(微生物保藏号CGMCC 45056)，以及基于弱毒株DEV SD70的重组病毒以及病毒株、疫苗和重组病毒用于水禽相关疫病的防治。

Description

预防或治疗禽病毒感染症的疫苗
技术领域
本申请涉及生物医药领域，更具体地涉及鸭疱疹病毒1型(Anatid herpesvirus1)病毒株、用于预防或治疗禽病毒感染症的包含该病毒株的疫苗以及基于该病毒株的重组病毒。
背景技术
鸭病毒性肠炎(duck virus enteritis)又称鸭瘟(duck plague)，是由鸭瘟病毒(duck plague virus)或鸭病毒性肠炎病毒(duck enteritis virus)引起的感染症。该感染症主要发生于雁形目鸭科成员，如鸭、鹅和天鸭等，是一种急性、高致死性疾病，严重危害水禽养殖业的发展，其病理特征主要为黏膜血管损伤出血、脏器出血坏死。免疫接种疫苗是预防鸭病毒性肠炎的有效措施之一。现阶段用于鸭瘟防治的疫苗为C-KCE弱毒株，该毒株是经过鸭胚传8代，再适应鸡胚继续传20余代致弱毒力获得(夏业才等主编，兽医生物制品学第2版，中国农业出版社，2018年)。近年来，有关该弱毒疫苗株的基因组序列已有报道，但其亲代毒株的遗传背景不清楚，导致对该毒株毒力致弱的分子遗传机制不甚清楚。了解和掌握鸭肠炎病毒毒力致弱的遗传演化，选育具有良好免疫原性弱毒株对于提高疫苗使用的安全性，开发鸭肠炎病毒重组活载体疫苗具有重要的理论和实际意义。
目前，对于安全且有效地用于预防或治疗禽病毒感染症的疫苗存在迫切需要。
发明内容
本申请的一方面提出一种鸭疱疹病毒1型(Anatid herpesvirus 1)病毒株，所述病毒株属于疱疹病毒科、α疱疹病毒亚科和马立克病毒属，其中所述病毒株具有SEQ ID NO:1所示的基因组序列或与SEQ ID NO:1所示序列具有至少90％同一性的基因组序列。
根据本申请的实施方案，所述病毒株的基因组包含SEQ ID NO:2所示的UL1序列。
根据本申请的示例性实施方案，所述病毒株为具有保藏号CGMCC 45056的DEVSD70。
根据本申请的示例性实施方案，所述病毒株DEV SD70具有SEQ ID NO:1所示的基因组序列。
根据本申请的示例性实施方案，所述病毒株DEV SD70具有如SEQ ID NO:2所示的UL1序列。
根据本申请的示例性实施方案，相对于病毒株DEV SD04的160663bp的基因组序列，病毒株DEV SD70的154685bp的基因组序列具有以下突变：
2311-5373位(3063nt)核苷酸的缺失，
146179-148673位(2495nt)核苷酸替换为388nt的编码框SORFx，
123708-123907位(200nt)核苷酸的缺失，
126731-127138位(408nt)核苷酸的缺失，
157484-157891位(408nt)核苷酸的缺失，
131060-131061位(104nt)核苷酸的***，和
153561-153562位(104nt)核苷酸的***。
本申请的又一方面提出一种用于预防或治疗禽病毒感染症的疫苗，包含治疗有效量的保藏编号为CGMCC 45056的病毒株DEV SD70。
根据本申请的实施方案，所述禽病毒感染症是鸭瘟病毒引起的疾病。在示例性实施方案中，所述禽病毒感染症为鸭病毒性肠炎。
根据本申请的实施方案，所述病毒株DEV SD70为活病毒株、减毒活病毒株或灭活病毒株。在示例性实施方案中，所述病毒株DEV SD70为活病毒株。
根据本申请的实施方案，所述疫苗中的所述病毒株DEV SD70以1×102TCID50/ml或TCID50/g至1×108TCID50/ml或TCID50/g的剂量存在。在示例性实施方案中，所述疫苗中的所述病毒株DEV SD70以5×104TCID50/ml或TCID50/g至2×106TCID50/ml或TCID50/g的剂量存在。
根据本申请的实施方案，所述疫苗还包括佐剂。
本申请的又一方面提出保藏编号为CGMCC 45056的病毒株DEV SD70在制备用于预防或治疗禽病毒感染症的药物中的用途，包括向有此需要的受试者施用包含治疗有效量的病毒株DEV SD70的疫苗。
根据本申请的实施方案，所述受试者包括鸡、鸭、鹅、雁、鸽、鹌鹑或鸵鸟。在示例性实施方案中，所述受试者为鸭。
根据本申请的实施方案，对于每只受试者，以1×102TCID50至1×108TCID50病毒株DEV SD70/次的剂量施用所述疫苗。在示例性实施方案中，对于每只受试者，以5×104TCID50至2×106TCID50病毒株DEV SD70/次的剂量施用所述疫苗。
根据本申请的实施方案，将所述疫苗经由皮下、皮内、肌内、静脉注射、口服或吸入的途径施用至所述受试者。在示例性实施方案中，将所述疫苗经由皮下施用至所述受试者。
根据本申请的实施方案，向所述受试者施用所述疫苗至少1次。在示例性实施方案中，以间隔60天施用2次的频率向所述受试者施用所述疫苗。
本申请的还又一方面提出一种重组病毒，所述重组病毒是基于以上方面所述的病毒株、优选为病毒株DEV SD70的工程化病毒，其中所述重组病毒包含编码水禽病毒的保护性抗原片段的外源基因，所述外源基因位于所述重组病毒中对应于所述病毒株的基因组中UL27至UL26之间非编码区的区域。
根据本申请的实施方案，所述保护性抗原片段为小鹅瘟病毒VP2(viralstructural protein2)蛋白、鸭圆环病毒Cap(capsid protein)蛋白、鹅星状病毒Cap(capsid protein)蛋白、禽流感病毒HA(Hemagglutinin)蛋白、禽流感病毒NA(Neuraminidase)蛋白、坦布苏病毒E蛋白和坦布苏病毒prM蛋白。在示例性实施方案中，所述禽流感病毒为H5N1、H5N6或H5N8。在示例性实施方案中，所述保护性抗原片段为小鹅瘟病毒VP2蛋白。
根据本申请的示例性实施方案，所述保护性抗原片段是具有SEQ ID No:3限定的序列的小鹅瘟病毒VP2蛋白。
根据本申请的实施方案，所述重组病毒用于预防或治疗鸡瘟病、鸭瘟病和鹅瘟病中的至少一种。
根据本申请的实施方案，所述重组病毒包括编码CMV启动子的核酸、编码水禽病毒的保护性抗原片段的外源基因、和编码bGH poly腺苷酸化信号的核酸。
本申请的还又一方面提出一种药物组合物，包含以上方面所述的重组病毒和药学上可接受的载体。
在本申请中，通过将分离得到的具有强病毒毒力的病毒株DEV SD04经鸡胚成纤维细胞连续传代70代而获得病毒毒力显著降低的病毒株DEV SD70。由此病毒株DEV SD70制备的针对禽病毒感染症特别是鸭病毒性肠炎的预防或治疗的新型疫苗具备病毒效价高、免疫原性好、安全性高且稳定有效的特点，能够有效地抵抗鸭肠炎病毒的感染。此外，本申请发明人基于病毒株DEV SD70进一步构建了重组病毒，允许在对应于病毒株DEV SD70的基因组中UL27至UL26之间非编码区的区域***针对不同水禽病毒的保护性抗原片段的外源基因，所述重组病毒可有利地用于制备多联疫苗。由此制备的多联疫苗免疫原性好且安全稳定，能够对禽类提供有效的保护。
附图说明
图1是根据本申请实施例的病毒株DEV SD04全基因组序列的进化树分析。
图2是根据本申请实施例的病毒株DEV SD70相对于病毒株DEV SD04的突变图。
图3是根据本申请实施例的病毒株DEV SD70的一步生长曲线图。
图4是根据本申请实施例的病毒株DEV SD70免疫后的抗体水平的示意图。
图5是根据本申请实施例的重组病毒rDEV-EGFP的构建图。
图6是根据本申请实施例的重组病毒rDEV-VP2的构建图谱。
图7是根据本申请实施例的重组病毒rDEV-VP2的遗传稳定性鉴定图。
图8是根据本申请实施例的病毒株DEV SD70和重组病毒rDEV-VP2免疫后的组织载毒量的测定图。
具体实施方式
本申请是基于发明人的以下发现做出的：本申请发明人首次经分离鉴定而获得的一种新型鸭瘟病毒株DEV SD04，所述病毒株DEV SD04经鸡胚成纤维细胞连续传代70代所获得的弱病毒株DEV SD70能够有效作为用于预防或治疗禽病毒感染症特别是鸭病毒肠炎的疫苗来使用。所述弱病毒株DEV SD70能够进一步用于开发重组病毒疫苗，该重组病毒允许在对应于所述病毒株DEV SD70的基因组中UL27至UL26之间非编码区的区域***针对不同水禽病毒的保护性抗原片段的外源基因，由此制备的包含治疗有效量的病毒株DEV SD70的疫苗或包含重组病毒的单联疫苗或多联疫苗免疫原性好、安全性高且稳定性强，能够对禽类提供有效的保护作用。
本申请的新型鸭瘟病毒株DEV SD04是从发病鸭体内分离的，经由测序得到的全基因组序列，通过NCBI数据库的比对，发现病毒株DEV SD04与Anatid alphaherpesvirus1strain SD(MN518864.1)同源性最高，达99.93％。***进化树结果显示该病毒株是单独分支，与鸭疱疹病毒1型Anatid alphaherpesvirus 1strain SD(MN518864.1)亲缘性最高。同时，将该病毒株进行对鸭瘟病毒高度保守的UL1序列的PCR扩增鉴定，UL1序列测序结果证实该病毒株属于鸭瘟病毒。因此，本申请的发明人将该新分离的鸭瘟病毒株命名为DEV SD04，并且于2021年12月10日送至北京市朝阳区北辰西路1号院3号中国科学院微生物研究所的中国微生物菌种保藏管理委员会普通微生物中心(CGMCC)进行保藏，保藏编号为CGMCC45055。
本申请的发明人发现所述病毒株DEV SD04在分类学上属于疱疹病毒科，α-疱疹病毒亚科，马立克病毒属，可以作为针对禽病毒感染症特别是鸭病毒性肠炎的预防或治疗的疫苗进行开发。进一步，本申请的发明人将分离得到的具有强病毒毒力的鸭肠炎病毒株DEVSD04经鸡胚成纤维细胞连续传代70代而获得的病毒毒力显著降低的弱病毒株DEV SD70，并且于2021年12月10日送至北京市朝阳区北辰西路1号院3号中国科学院微生物研究所的中国微生物菌种保藏管理委员会普通微生物中心(CGMCC)进行保藏，保藏编号为CGMCC45056。由此病毒株DEV SD70制备的针对禽病毒感染症特别是鸭病毒性肠炎的预防或治疗的新型疫苗具备病毒效价高、免疫原性好、安全性高且稳定有效的特点，因而能够有效地抵抗鸭肠炎病毒的感染。
本申请发明人还出乎意料地发现病毒株DEV SD70基因组大、非必需基因多、能容纳大容量的外源基因、具有较多的可***位点、遗传稳定、受母源抗体影响小、以及体内存活时间较长等，因而具有开发重组病毒疫苗的潜力。进一步，本申请发明人基于所述病毒株DEV SD70构建了重组病毒作为疫苗，所述重组病毒允许在对应于所述病毒株的基因组中UL27至UL26之间非编码区诸如69207-69658位的区域***针对不同水禽病毒的保护性抗原片段的外源基因。获得的重组病毒能够用于制备疫苗、特别是多联疫苗，用于有效地预防或治疗鸡瘟病、鸭瘟病和鹅瘟病中的至少一种，也就是说，可以用于有效地预防或治疗鸡瘟病、可以用于有效地预防或治疗鸭瘟病、可以用于有效地预防或治疗鹅瘟病、也可以用于有效地预防或治疗鸡瘟病、鸭瘟病以及鹅瘟病三者。由此制备的单联疫苗或多联疫苗具有免疫原性好、安全性高且稳定性强的特点，能够提供有效的保护。
因此，根据本申请的一方面，本申请提出一种鸭疱疹病毒1型(Anatidherpesvirus 1)病毒株，所述病毒株属于疱疹病毒科、α疱疹病毒亚科和马立克病毒属，其中所述病毒株具有SEQ ID NO:1所示的基因组序列或与SEQ ID NO:1所示序列具有至少90％同一性的序列。所述“至少90％同一性的序列”是指与SEQ ID NO:1所示的基因组序列具有90％至100％之间的任意数值(包括端点值)所示的同一性的序列，例如可以具有90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或100％的序列同一性，以及两个相邻的整数之间的无数个小数所示的序列同一性。
在本申请的实施例中，病毒株DEV SD70具有SEQ ID NO:1所示的基因组序列。“基因组序列”在此是指病毒株的全基因组序列。根据本申请的示例性实施方案，所述病毒株DEV SD70具有CGMCC 45056的保藏号。
在本申请中，具有SEQ ID NO:1所示的基因组序列的病毒株DEV SD70可以由本领域的技术人员理解为原始病毒株。与SEQ ID NO:1所示序列具有至少90％同一性的基因组序列的病毒株可以由本领域的技术人员理解为具有SEQ ID NO:1所示的基因组序列的病毒株DEV SD70的变体病毒株。本领域的技术人员理解病毒株如病毒株DEV SD70可以发生自发突变或经过人工培养以形成变体病毒株，例如发生核苷酸的缺失、核苷酸的添加、或核苷酸的交换。“变体病毒株”与“病毒株DEV SD70”具有高度相同的基因序列以及极其相似的生物学功能。其中突变的基因基本上不会影响病毒株DEV SD70的保守序列，因而不会影响病毒株DEV SD70的遗传稳定性。更具体地说，该“变体病毒株”也是鸭瘟病毒，表现鸭瘟病毒的常见特征。
根据本申请的实施方案，本申请意图的病毒株包括病毒株DEV SD70以及病毒株DEV SD70的变体病毒株。所述变体病毒株具有与SEQ ID NO:1所示序列具有至少90％的同一性、如90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或100％的同一性的基因组序列。根据本申请的实施方案，所述变体病毒株具有SEQ ID NO:2所示的UL1序列。
在示例性实施例中，所述变体病毒株可以包括本文提出的病毒株DEV SD04。所述病毒株DEV SD04具有CGMCC 45055的保藏号。在本申请中，鉴于基因组序列的高度同一性以及相似的生物学功能，该病毒株DEV SD04可被认为是病毒株DEV SD70的变体。
根据本申请的示例性实施方案，本申请的病毒株可以为具有保藏号CGMCC 45055的DEV SD04。根据本申请的示例性实施方案，本申请的病毒株可以为具有保藏号CGMCC45056的DEV SD70。
根据本申请的实施方案，所述病毒株DEV SD70具有SEQ ID NO:2所示的UL1序列。根据本申请的实施方案，所述病毒株DEV SD04具有SEQ ID NO:2所示的UL1序列。所述病毒株DEV SD04和所述病毒株DEV SD70具有完全相同的UL1序列。
ctatcgtcggccatggtgtccgggttcacttttgtcatgtcttcggccatatctcgagtctggatcgaatgcataacggatgctggcctgagggtctttgaagcgatgcatattcgcgtttccgtggcaggttctgtcatttgggtctccctcgttgacacagccagtacctacaggcgcagtactaaagctcggcttcccgccccacgctgaatttaaggctttctgaaaagccttgacccccacgtcatcacctattgcaacttcagagtccagcaaaaacccagaaatcgcaaggttagggttgacccataatgcccgctgtggacgctcataccacaaaactacctcaatttggggacagtgactgcggataaatactccagacaacaactccgtgctctttggtggtacagctgcataggttgaagtctccgaggtccctgggcggaggcagtccctagatagtatagacaggacatctggagcatacataactccttcgataaccgggtaactacaggaagtttcttcaaaaaaacccattacgactaggatcacgagcgccaatctatgtaaagtccaacccattgtcccgcaccacaagttcggaacgtttcgttcttcggccaccggacgcactacgtgtataacacgatgccgtattatacctacaagtgttttcaagacggccttccatctggaacccat(SEQ ID NO:2)
本申请实施方案的鸭肠炎病毒株DEV SD04是本申请发明人首次经分离鉴定而获得的一种新型鸭瘟病毒株，其被鉴定为属于疱疹病毒科、α-疱疹病毒亚科、马立克病毒属的一种新型病毒株，可将其有利地用于开发针对禽病毒感染症特别是鸭病毒性肠炎的预防或治疗的新型疫苗，由此制备的疫苗具备免疫原性好、安全性高且有效使用的优势。
根据本申请的示例性实施方案，相对于病毒株DEV SD04的160663bp的基因组序列，病毒株DEV SD70的154685bp的基因组序列具有以下突变：
2311-5373位(3063nt)核苷酸的缺失，
146179-148673位(2495nt)核苷酸替换为388nt的编码框SORFx的核苷酸，
123708-123907位(200nt)核苷酸的缺失，
126731-127138位(408nt)核苷酸的缺失，
157484-157891位(408nt)核苷酸的缺失，
131060-131061位(104nt)核苷酸的***，和
153561-153562位(104nt)核苷酸的***。
其中，所述146179-148673位(2495nt)核苷酸替换为388nt的编码框SORFx是指病毒株DEV SD70的基因组中相对于病毒株DEV SD04的基因组的146179-148673位的2495nt的核苷酸缺失并且在该缺失的146179-148673位区域***388nt的编码框SORFx的核苷酸。也就是说，该146179-148673位区域的核苷酸被替换为388nt的编码框SORFx的核苷酸。
本申请实施方案的鸭肠炎病毒株DEV SD70是将分离得到的具有强病毒毒力的鸭肠炎病毒株DEV SD04经鸡胚成纤维细胞连续传代70代而获得的病毒毒力显著降低的弱病毒株。由此病毒株DEV SD70制备的针对禽病毒感染症特别是鸭病毒性肠炎的预防或治疗的新型疫苗具备病毒效价高、免疫原性好、安全性高且稳定有效的特点，因而能够有效地抵抗鸭肠炎病毒的感染。此外，本申请发明人出乎意料地发现病毒株DEV SD70基因组大、非必需基因多、能容纳大容量的外源基因、具有较多的可***位点、遗传稳定、受母源抗体影响小、以及体内存活时间较长等，因而可被进一步用于开发重组病毒疫苗。
根据本申请的又一方面，本申请提出一种用于预防或治疗禽病毒感染症的疫苗，包含治疗有效量的保藏编号为CGMCC 45056的病毒株DEV SD70。所述疫苗具有免疫原性好、安全性高且稳定性强的特定，能够有效抵抗禽病毒感染症特别是鸭病毒性肠炎，对禽类提供有效的保护作用。
根据本申请的实施方案，所述禽病毒感染症是由鸭瘟病毒引起的疾病。在示例性实施方案中，所述禽病毒感染症为鸭病毒性肠炎。
根据本申请的实施方案，所述病毒株DEV SD70为活病毒株、减毒活病毒株或灭活病毒株。在示例性实施方案中，所述病毒株为活病毒株。
在本申请的疫苗中使用的病毒株DEV SD70如前所述，可以使用活的病毒株、通过化学或热方式杀死的死病毒株或灭活病毒株。本申请的病毒株DEV SD70是将分离得到的具有强病毒毒力的病毒株DEV SD04经鸡胚成纤维细胞连续传代70代而获得的病毒毒力显著降低的弱病毒株，因此可以使用活的病毒株作为疫苗的有效成分。活病毒株的疫苗与灭活病毒株的疫苗相比，其能够诱导先天免疫及适应免疫反应，因此有利于诱导保护性免疫。而且，活病毒株的疫苗能够形成经持续抗原刺激的记忆免疫细胞，因此有利于免疫。本申请的发明人已经通过实验证实该活病毒株作为疫苗具有较高的安全性、免疫原性和稳定性。
根据本申请的实施方案，所述疫苗中的所述病毒株DEV SD70以1×102TCID50/ml或TCID50/g至1×108TCID50/ml或TCID50/g的剂量存在。在示例性实施方案中，所述疫苗中的所述病毒株DEV SD70以5×104TCID50/ml或TCID50/g至2×106TCID50/ml或TCID50/g的剂量存在。通过使用如上所述的施用剂量，本申请的疫苗能够安全且有效地预防或治疗禽病毒感染症，特别是能够安全且有效地预防或治疗鸭病毒性肠炎。
根据本申请的实施方案，所述疫苗还包括佐剂，由此能够诱发高效的特异性免疫反应，提高机体保护能力，同时又能减少免疫物质的用量，降低疫苗的生产成本。根据本申请的实施方案，所述佐剂可以为氢氧化铝、磷酸铝、硫酸铝钾、交联聚丙烯酸聚合物、双十八烷基二甲基溴化铵、免疫调节物质、乳铁蛋白或γ-干扰素诱导剂中的一种以上。
本申请的疫苗可剂型化为全身或局部给药用药剂，可以包含药学上可接受的载体，例如磷酸缓冲用食盐水溶液、蒸馏水、水/乳乳剂、润湿剂、乳化剂、pH调节剂等。
根据本申请的又一方面，本申请提出保藏编号为CGMCC 45056的病毒株DEV SD70在制备用于预防或治疗禽病毒感染症的药物中的用途，包括向有此需要的受试者施用包含治疗有效量的病毒株DEV SD70的疫苗。
根据本申请的又一方面，本申请提出一种用于预防或治疗禽病毒感染症的方法，包括向有此需要的受试者施用包含治疗有效量的病毒株DEV SD70的疫苗。所述病毒株DEVSD70具有保藏编号CGMCC 45056。
根据本申请的实施方案，所述受试者为雁形目禽类。在示例性的实施方案中，所述受试者为家禽。在示例性的实施方案中，所述受试者包括鸡、鸭、鹅、雁、鸽、鹌鹑或鸵鸟。在示例性实施方案中，所述受试者为鸭。所述鸭包括中国养殖业的各种品种。
根据本申请的实施方案，对于每只受试者，尤其是鸭，以1×102TCID50至1×108TCID50病毒株DEV SD70/次的剂量施用所述疫苗。在示例性实施方案中，对于每只受试者，以5×104TCID50至2×106TCID50病毒株DEV SD70/次的剂量施用所述疫苗。通过使用如上所述的施用剂量，本申请的疫苗能够安全且有效地预防或治疗鸭病毒性肠炎。
根据本申请的实施方案，将所述疫苗经由皮下、皮内、肌内、静脉注射、口服或吸入的途径施用至所述受试者。在示例性实施方案中，将所述疫苗经由皮下施用至所述受试者，尤其是鸭。
根据本申请的实施方案，向所述受试者，尤其是鸭施用所述疫苗至少1次。在示例性实施方案中，以间隔60天施用2次的频率向所述受试者施用所述疫苗。
在本申请的如上方面描述的防治用途以及防治方法具有如上方面描述的疫苗的特征和效果，在此不再赘述。
根据本申请的还又一方面，本申请提出一种重组病毒，所述重组病毒是基于以上方面所述的病毒株、优选为病毒株DEV SD70的工程化病毒，其中所述重组病毒包含编码水禽病毒的保护性抗原片段的外源基因，所述外源基因位于所述重组病毒中对应于所述病毒株的基因组中UL27至UL26之间非编码区诸如69207-69658位的区域。
本申请实施方案的重组病毒是采用分子生物学手段将病毒株DEV SD70进行基因工程化改造而获得的病毒，其允许在对应于所述病毒株的基因组中UL27至UL26之间非编码区诸如69207-69658位的区域***针对不同水禽病毒的保护性抗原片段的外源基因，可有利地用于制备单联疫苗或多联疫苗。由此制备的单联疫苗或多联疫苗免疫原性好、安全性高且稳定性强，能够对禽类提供有效的保护作用。
根据本申请的实施方案，所述保护性抗原片段为小鹅瘟病毒VP2(viralstructural protein2)蛋白、鸭圆环病毒Cap(capsid protein)蛋白、鹅星状病毒Cap(capsid protein)蛋白、禽流感病毒HA(Hemagglutinin)蛋白、禽流感病毒NA(Neuraminidase)蛋白、坦布苏病毒E蛋白和坦布苏病毒prM蛋白。由此，通过采用本申请中特定设计的重组病毒，可以制备单联疫苗或多联疫苗。
在示例性实施方案中，所述保护性抗原片段为小鹅瘟病毒VP2蛋白。由此，可以将包含小鹅瘟病毒VP2基因的DEV SD70病毒构建为多联疫苗，用于预防或治疗鸭瘟病和鹅瘟病二者。
根据本申请的实施方案，所述小鹅瘟病毒VP2蛋白具有SEQ ID No:3限定的序列。
TAPAKKNTGKLTDHYPVVKKPKLTEEVSAGGGSSAVQDGGATAEGTEPVAASEMAEGGGGALGDASGGADGVGNASGNWHCDSQWMGNTVITKTTRTWVLPSYNNHIYKAITSGTSQDANVQYAGYSTPWGYFDFNRFHCHFSPRDWQRLINNHWGIRPKSLKFKIFNVQVKEVTTQDQTKTIANNLTSTIQVFTDDEHQLPYVLGSATEGTMPPFPSDVYALPQYGYCTMHTNQNGARFNDRSAFYCLEYFPSQMLRTGNNFEFTFDFEEVPFHSMFAHSQDLDRLMNPLVDQYLWNFNEVDSSRNAQFKKAVKGAYGTMGRNWLPGPKFLDQRVRAYTGGTDNYANWNIWSNGNKVNLKDRQYLLQPGPVSATHTEAEASSIPAQNILGLAKDPYRSGSTTAGISDVMVTDEQEVAPTNGVGWKPYGKTVTNEQNTTTAPTSSDLDVLGALPGMVWQNRDIYLQGPIWAKIPKTDGKFHPSPNLGGFGLHNPPPQVFIKNTPVPADPPVEYVHQKWNSYITQYSTGQCTVEMVWELRKENSKRWNPEIQFTSNFSDRTSIMFAPNETGGYIEDRLIGTRYLTQNL(SEQ ID No:3)
根据本申请的实施方案，所述重组病毒用于预防或治疗鸡瘟病、鸭瘟病和鹅瘟病中的至少一种。所述重组病毒可以用于预防或治疗鸡瘟病。所述重组病毒可以用于预防或治疗鸭瘟病。所述重组病毒可以用于预防或治疗鹅瘟病。所述重组病毒还可以用于预防或治疗鸡瘟病、鸭瘟病和鹅瘟病三者。
根据本申请的实施方案，所述重组病毒包括编码CMV启动子的核酸、编码水禽病毒的保护性抗原片段的外源基因、和编码bGH poly腺苷酸化信号的核酸。
在本申请中，与如上方面所述的病毒株DEV SD70相比，基于病毒株DEV SD70的所述重组病毒包含编码水禽病毒的保护性抗原片段的外源基因，所述外源基因位于对应于病毒株DEV SD70的基因组中UL27至UL26之间非编码区诸如69207-69658位的区域。由此，可以将所述重组病毒制备用于预防或治疗水禽病毒引起的感染症的疫苗组合物。在示例性实施方案中，所述重组病毒为rDEV-VP2，具有如图6所示的结构。
根据本申请的还又一方面，本申请提出一种药物组合物，包含以上方面所述的重组病毒和药学上可接受的载体。根据本申请的实施方案，药学上可接受的载体包括磷酸缓冲用食盐水溶液、蒸馏水、水/乳乳剂、润湿剂、乳化剂、pH调节剂等。所述药物组合物具有如上描述的重组病毒的特征和效果，在此不再赘述。
在本申请中，所述药物组合物可以作为疫苗组合物使用。所述疫苗组合物可以用于预防或治疗水禽病毒引起的感染症，特别是鸭病毒性肠炎。所述疫苗组合物可以是单联疫苗。所述疫苗组合物也可以是多联疫苗。
以上方面描述的包含病毒株DEV SD70的疫苗的各种特征，比如施用对象、施用剂量、施用途径、施用频率以及治疗功效等同样适合用于本申请的药物组合物，在此不再赘述。
根据本申请的还又一方面，本申请提出用于预防或治疗禽病毒感染症的方法，包括向有此需要的受试者施用包含治疗有效量的重组病毒的药物组合物。
根据本申请的还又一方面，本申请提出如上方面描述的重组病毒在制备用于预防或治疗禽病毒感染症的药物中的用途，包括向有此需要的受试者施用包含治疗有效量的重组病毒的药物组合物。
在此处描述的针对重组病毒的防治方法和防治用途具备以上方面描述的针对包含病毒株DEV SD70的疫苗的防治方法和防治用途的部分特征，在此不再赘述。
根据本申请的还又一方面，本申请提出制备以上方面所述的重组病毒的方法，包括：在基于以上方面所述的病毒株、优选为病毒株DEV SD70中***编码水禽病毒的保护性抗原片段的外源基因，所述外源基因位于所述重组病毒中对应于所述病毒株的基因组中UL27至UL26之间非编码区诸如69207-69658位的区域。
根据本申请的实施方案，所述保护性抗原片段为小鹅瘟病毒VP2蛋白、鸭圆环病毒Cap蛋白、鹅星状病毒Cap蛋白、禽流感病毒HA蛋白、禽流感病毒NA蛋白、坦布苏病毒E蛋白、坦布苏病毒prM蛋白等。在示例性的实施方案中，所述保护性抗原片段为小鹅瘟病毒VP2蛋白。
为了帮助本申请的理解，下面示出实施例。但以下实施例只是为了更加易于理解本申请而提供的，本申请并不限于以下的实施例。
实施例
实施例1：病毒株DEV SD04的分离和鉴定
病毒的分离：在2004年从养殖户送检的发病鸭体内分离出一种未知株。首先进行细菌的分离鉴定，经鉴定排除细菌疾病感染。选取出血坏死病变明显的肝脾等脏器，研磨制备组织悬液。过滤除菌后，通过***接种方式接种8日龄的鸭胚，弃去24小时内死亡的鸭胚，待胚体死亡后，收集胚体及尿囊液，同时观察胚体的病变情况，胚体严重出血和肝脏坏死。以相同的方式连续传代几次，使其完全适应鸭胚增殖。将收集的尿囊液，提取DNA，针对鸭瘟病毒的高度保守的基因序列UL1区设计特异性的引物，如表1所示，进行PCR鉴定。
表1DEV病毒株鉴定的特异性引物
琼脂糖凝胶电泳显示，特异性条带出现在1116bp处，测序结果也证实是UL1序列，由此证明该分离的病毒株是鸭瘟病毒，命名为DEV SD株。
全基因组序列测定：为了获得该病毒株的序列，选择传代4代后的病毒株(即DEVSD04)进行基因组测序。将该病毒株的DNA样品送至上海瀚宇生物科技有限公司进行高通量测序，对病毒株DEV SD04进行全基因组测序。全基因组测序结果为病毒株DEV SD04的全基因组为160663bp。将该病毒株的全基因组序列于NCBI数据库进行比对，发现与鸭疱疹病毒1型Anatid alphaherpesvirus 1strain SD(登录号：MN518864.1)同源性最高，高达99.93％。***进化树结果显示该病毒株是单独分支，与鸭疱疹病毒1型Anatid alphaherpesvirus1strain SD(登录号：MN518864.1)亲缘性最高(参见图1)。因此，确定该病毒株为新分离的一株鸭瘟病毒株。
DEV SD04的致病性：取10只20日龄的雏鸭，以5×104TCID50的DEV SD04/次的剂量经颈背部皮下注射来接种每只雏鸭。观察接种后雏鸭的发病及死亡情况，接种后3天雏鸭出现精神沉郁，垂头缩颈，部分鸭头部皮下出现胶冻样渗出，肿头的现象，剖检病理变化肝脏、脾脏坏死出血，肠道出血坏死，胰腺出血等病理变化，结果见表2。接种后4天，雏鸭开始出现死亡。接种后5天，雏鸭死亡到达高峰期。结果说明，鸭瘟病毒株DEV SD04毒力很强，致使被感染鸭死亡。
表2鸭瘟病毒株DEV SD04的致病性实验
病毒株DEV SD04的微生物保藏：该病毒株DEV SD04作为原始种毒株，于2021年12月10日送至北京市朝阳区北辰西路1号院3号中国科学院微生物研究所的中国微生物菌种保藏管理委员会普通微生物中心(CGMCC)保藏，保藏编号CGMCC 45055。
实施例2：病毒株DEV SD70的选育及生物学特性
2.1弱病毒株的选育
强毒力的鸭瘟病毒株DEV SD04在鸭胚成纤维细胞上适应8代后，接种无特定病原(SPF)的鸡胚成纤维细胞(CEF)。按照常规方法制备CEF细胞，将鸭肠炎病毒株DEV SD04适当稀释后接种于长满单层CEF细胞的细胞瓶内，定时在倒置显微镜下观察CEF细胞病变。待CEF细胞出现80％左右的细胞病变(CPE)时收集病毒液。以相同的方式在制备的CEF细胞中进行连续传代以致弱毒力，连续传代70代，克隆纯化得到弱病毒株，将其命名鸭肠炎病毒株DEVSD70。将该病毒株的DNA样品送至上海瀚宇生物科技有限公司进行高通量测序，对病毒株DEV SD70进行全基因组测序。全基因组测序结果为病毒株DEV SD70的全基因组为154685bp，如SEQ ID NO:1所示。
病毒株DEV SD70的微生物保藏：病毒株DEV SD70已于2021年12月10日送至北京市朝阳区北辰西路1号院3号中国科学院微生物研究所的中国微生物菌种保藏管理委员会普通微生物中心(CGMCC)进行保藏，保藏编号CGMCC 45056。
2.2生物学特性
2.2.1繁殖特性
鸭瘟病毒株DEV SD70接种SPF级的CEF细胞，感染复数(MOI)为0.01，测定病毒一步生长曲线，结果见图3。培养72小时时病毒含量达最高，为105.6TCID50/0.1ml，结果说明该毒株DEV SD70在CEF细胞中具有良好的繁殖特性。
2.2.2安全性及稳定性
7日龄的雏鸭和30日龄的鸭各10只，以2×106TCID50的病毒株DEV SD70/次的剂量经颈背部皮下免疫接种每只鸭。连续观察14天，每只鸭无任何发病症状，均健活，结果见表3，说明鸭瘟病毒株DEV SD70毒力很弱，对鸭产生良好的安全性。
表3鸭瘟病毒株DEV SD70对不同日龄鸭的致病性
注“-”表示未出现临床症状
取25枚8日龄的SPF鸡胚，分为5组，每组5个，分别注射10-2至10-6稀释度的鸭瘟病毒株DEV SD70。连续观察14天，结果如表4，各稀释度的DEV SD70均不致死鸡胚，表明鸭瘟病毒株DEV SD70毒力很弱，不会致死鸡胚，对鸡胚没有致病性。
表4DEV SD70对鸡胚的致病性
以2×106TCID50的病毒株DEV SD70/次/只的剂量经颈背部皮下免疫接种10只5日龄的雏鸭。免疫接种后3天进行剖杀，采取脏器以制备20％组织悬液。以相同的方式接种下一代，连续回传5代。利用SYBR Green荧光染料法测定各个代次的组织带毒量，结果见表5，说明只能在P1代中的部分鸭子体内检测到该鸭瘟病毒株DEV SD70，该该鸭瘟病毒株DEVSD70在鸭的机体内是有限性复制，对雏鸭有很好的安全性，以及具有良好稳定性的生物学特征。
表5返强实验的组织中病毒的检测结果
2.2.3免疫原性
以5×104TCID50的病毒株DEV SD70/次/只的剂量经颈背部皮下免疫接种8只麻鸭。免疫接种后60天，以1×105TCID50的病毒株DEV SD70/次/只的剂量进行第二次免疫接种。定点采血，使用阻断ELISA方法测定其抗体水平。结果如图4所示，免疫接种后7天抗体开始转阳性，免疫接种后15天抗体水平可达较高水平，第一次免疫后60天仍能检测到抗体阳性。免疫接种后60天进行第二次免疫，抗体水平明显升高且维持较长时间直至检测期结束，免疫接种后140天抗体水平仍能维持在阻断率50％以上。
以5×104TCID50的病毒株DEV SD70/次//只的剂量经颈背部皮下免疫接种10只鸭。免疫接种后15天，以100倍最小致死量的鸭瘟强病毒株DEV SD04施用至每只鸭。每天观察鸭的发病及死亡情况，DEV SD70免疫组鸭均未出现任何发病症状，观察期间均健康存活；而未免疫组(DMEM组)的所有鸭都死亡，出现明显的发病症状，剖检病变为典型的鸭瘟症状，如出现肝脏和脾脏的出血坏死、肠道的出血。结果如表6所示，说明鸭瘟病毒株DEV SD70能够良好地保护鸭以抵抗鸭瘟病毒强毒株的攻击。结果证实该病毒株DEV SD70具有良好的免疫原性。
表6DEV SD70对鸭的保护性
2.2.4全基因组序列
将鸭瘟病毒株DEV SD70的DNA样品送至上海瀚宇生物科技有限公司，通过高通量测序技术对该病毒株DEV SD70进行全基因组测序。测序结果表明病毒株DEV SD70的全基因组为154685bp。通过序列比对分析，将病毒株DEV SD70的154685bp的基因组与病毒株DEVSD04的160663bp的基因组相比，发现DEV SD70相比于DEV SD04具有如下突变：缺失了如下片段，2311-5373位的核苷酸共3063nt的缺失、146179-148673位的核苷酸共2495nt的缺失并替换为388nt的编码框SORFx、123708-123907位的核苷酸共200nt的缺失、126731-127138位的核苷酸共408nt的缺失和157484-157891位的核苷酸共408nt的缺失，以及在131060-131061位和153561-153562位之间各有104nt的***。以上突变对蛋白US8(gE蛋白)和US5(gJ蛋白)的影响最大，使得gE和gJ蛋白结构发生改变，其中在US8中，592位碱基由C突变为A；在US5中，440位(G)与441位(G)位之间***碱基G。传代前后的DEV SD04和DEV SD70的基因组序列改变参见图2。
实施例3：基于病毒株DEV SD70的重组病毒的构建
基于鸭瘟病毒株DEV SD70构建重组病毒。具体地，在对应于病毒株DEV SD70的基因组中UL27至UL26之间非编码区的区域***编码不同水禽病毒的保护性抗原片段的外源基因，以构建相应的重组病毒。所述重组病毒用作为单联疫苗或多联疫苗以预防或治疗鸭瘟和相应的水禽病毒引起的疾病。
3.1rDEV-EGFP重组病毒的构建
以选择的弱病毒株DEV SD70为病毒载体。首先选择便于筛选鉴定的EGFP表达框，将所述EGFP表达框***DEV SD70的基因组的ul27与ul26之间的非编码区中，以便获得可以表达绿色荧光蛋白的重组病毒rDEV-EGFP。构建策略参见图5，重组病毒的拯救步骤具体如下所述。
使用CRISPR/Cas9***进行病毒的拯救，构建表达cas9蛋白的gRNA质粒。拯救病毒的转染操作为：使用常规方法将鸡胚成纤维细胞接种于12孔板内(约4×105个细胞/孔)，待细胞贴壁生长至80％-90％时进行转染；使用Opti-MEM培养基进行3次细胞洗涤以除去原有培养基中的血清，每孔加入400μl的Opti-MEM培养基，置于37℃中备用；随后取一个无菌EP管进行DNA的稀释，gRNA质粒与donor DNA片段各1.5μg稀释于Opti-MEM培养基中，混匀后加入3μl的P3000试剂；另取一个EP管进行脂质体的稀释，3.4μl的lipofectamine 3000稀释于Opti-MEM培养基内；两个EP管内液体进行轻柔混匀，室温反应15min，随后将其均匀加入到处理好的细胞培养板内，转染后4小时进行更换维持液，待转染16小时后，以1.0的MOI的毒量接种弱病毒株DEV SD70。每天观察鸡胚成纤维细胞的状态，约48-60小时进行收毒，所收的病毒液以1:2的比例接种于两个6孔板内以去除质粒的瞬时表达，48小时后即可置于荧光显微镜下观察有无表达绿色荧光的重组病毒。如看到表达绿色荧光的重组病毒，则进行连续5轮的噬斑纯化和有限次稀释交替的方法进行纯化直至筛选出纯的重组病毒rDEV-EGFP。通过PCR扩增和测序以鉴定EGFP表达框序列的正确性以及***位点的准确性。
3.2重组病毒rDEV-VP2的构建
利用上述同样的方法进行重组病毒rDEV-VP2的构建。为了便于筛选重组病毒、增加重组病毒的同源重组及拯救效率，本申请的实施例采用双gRNA敲除的CRISPR/Cas9***来敲除EGFP的ORF，进而利用细胞的修复机制(即，同源介导的修复机制(HDR))将编码细小病毒结构蛋白VP2的基因组***至对应重组病毒rDEV-EGFP的EGFP表达框的区域内，经过筛选纯化获得表达细小病毒结构蛋白VP2的鸭肠炎重组病毒，命名为rDEV-VP2。构建策略参见图6，重组病毒rDEV-VP2的拯救步骤与如上所述的rDEV-EGFP重组病毒的拯救步骤相似。
实施例4：重组病毒rDEV-VP2的生物学特征
4.1重组病毒rDEV-VP2的安全性
7日龄的雏鸭和30日龄的鸭各10只，以1.2×106TCID50的rDEV-VP2/次/只的剂量经颈背部皮下免疫每只鸭。连续观察14天，鸭无任何发病症状，均健活，结果见表7。结果说明鸭瘟重组病毒rDEV-VP2的毒力很弱，对鸭有良好的安全性。
表7重组病毒rDEV-VP2对不同日龄鸭的致病性
注：“-”表示未发生任何临床症状
以1.2×106TCID50的rDEV-VP2/次/只的剂量经颈背部皮下免疫10只5日龄雏鸭。免疫接种后3天进行剖杀，采取脏器制备20％组织悬液。以相同的方式接种下一代，连续回传5代，利用SYBR Green荧光染料法测定各个代次的组织带毒量，结果见表8。结果说明只能在P1代中的部分鸭子体内检测到该鸭瘟重组病毒rDEV-VP2，该鸭瘟重组病毒rDEV-VP2在鸭机体内是有限性复制，对雏鸭有很好的安全性，具有稳定的生物学特征。
表8 rDEV-VP2返强实验的组织中病毒的检测结果
4.2重组病毒rDEV-VP2的稳定性
将该重组病毒rDEV-VP2在CEF细胞连续传代20代，每隔5代进行IFA和WesternBlot鉴定VP2蛋白的表达情况，并测序以验证有无碱基的突变。
多步生长曲线测定：将纯化的重组病毒rDEV-VP2与弱病毒株DEV SD70分别以MOI＝0.01的毒量接种于事先制备的长至90％左右的CEF内，每隔12小时进行收毒，所收的病毒液利用Reed-Muench法计算各个时间点的病毒滴度TCID50，利用GraphPad Prism 7.0绘制多步生长曲线以及进行显著性差异分析。结果如图7所示，该重组病毒能稳定在CEF细胞内表达，不发生任何突变，生长特性也没有任何改变，说明该重组病毒rDEV-VP2具有良好的稳定性。同时说明弱病毒株DEV SD70可以作为重组病毒使用，对应于DEV SD70基因组的69207-69658位的区域的***位点适合用于外源基因的***。
4.3重组病毒rDEV-VP2的免疫原性及保护效力
将68只6日龄的北京雏鸭随机分组，6日龄的雏鸭经颈背部皮下进行rDEV-VP2和DEV SD70的免疫。免疫接种后14天，分别以1.5×105ELD50/只的剂量进行细小病毒强毒DEVSD04的攻击。攻毒后4天、8天、12天分别进行雏鸭剖杀，采集肝、脾、胸腺、法氏囊、盲肠扁桃体，利用PCR扩增检测脏器载毒。免疫接种后30天，以1.5×105ELD50/只的剂量进行细小病毒强毒DEV SD04的再次攻击。实验鸭在攻毒后4天进行剖杀，进行脏器采集及脏器载毒量的PCR扩增检测。
实验的实施方案如表9所示。结果如图8，相比于免疫接种不含外源基因的DEVSD70(即，空白对照组)，免疫接种重组病毒rDEV-VP2后的鸭子脏器组织的病毒含量明显更低，这说明重组病毒rDEV-VP2能更加有效地抑制细小病毒的复制，提供有效的保护。
表9 rDEV-VP2免疫保护实验设计方案
注“-”表示不作任何处理
综上，重组病毒rDEV-VP2具有良好安全性、免疫原性以及稳定性，能产生针对***蛋白的特异性抗体，为经免疫的鸭提供良好的保护。
实施例5：其它重组病毒的构建及生物学特征
5.1鸭瘟病毒株DEV SD70可作为重组病毒的载体，在对应于病毒株DEV SD70的基因组69207-69658位的区域按照常规生物学技术***鹅星状病毒的Cap蛋白的表达框以构建重组病毒作为二联疫苗。该构建的重组病毒作为二联疫苗经实验证实可以有效地预防鸭瘟和鹅肾致型痛风二者。
5.2鸭瘟病毒株DEV SD70可作为重组病毒的载体，在对应于病毒株DEV SD70的基因组69207-69658位的区域按照常规生物学技术***鸭圆环病毒的Cap蛋白的表达框以构建重组病毒作为疫苗。该构建的重组病毒作为疫苗经实验证实可以有效地预防鸭瘟病毒和鸭圆环病毒二者。
5.3鸭瘟病毒株DEV SD70可作为重组病毒的载体，在对应于病毒株DEV SD70的基因组69207-69658位的区域按照常规生物学技术***禽流感病毒HA蛋白的表达框以构建重组病毒作为疫苗。该构建的重组病毒作为疫苗经实验证实可以有效地预防鸡瘟病和鸭瘟病。
5.4鸭瘟病毒株DEV SD70可作为重组病毒的载体，在对应于病毒株DEV SD70的基因组69207-69658位的区域按照常规生物学技术***坦布苏病毒E蛋白的表达框以构建重组病毒作为疫苗。该构建的重组病毒作为疫苗经实验证实可以有效地预防鸭瘟病和鹅瘟病。
在本申请中，术语“一个实施例”、“一些实施例”、“示例”、“具体示例”、或“一些示例”等意指结合该实施例或示例描述的具体特征、结构、材料或者特点包含于本申请的至少一个实施例或示例中。在本说明书中，对上述术语的示意性表述不必须针对的是相同的实施例或示例。而且，描述的具体特征、结构、材料或者特点可以在任一个或多个实施例或示例中以合适的方式结合。
在不相互矛盾的情况下，本领域的技术人员可以将本说明书中描述的不同实施例或示例以及不同实施例或示例的特征进行结合和组合。
序列表
<110> 中国农业大学
<120> 预防或治疗禽病毒感染症的疫苗
<130> E1218067
<160> 5
<170> PatentIn version 3.5
<210> 1
<211> 154685
<212> DNA
<213> 人工序列
<220>
<223> DEV SD70全基因组序列
<400> 1
gtccaacgcc tctcccggcc gcggccgcgc agaaaaaaat ttttgcctga cgtgccttca 60
atgcactgct atggaagggc gttgggggat gggccactca cattctttgc gcacatacac 120
atagcggtca ggcccttact tggctacttg ccaacaaaac tcaagtttgt atttcacgcc 180
ctggcagcgt gccaactcgc tttgcatcgc caagcagttc cccgaaaagc aagctgttgt 240
ttcggagtta cagctgccgc cggcgatgac gtactacatg gtacttgaaa cattgccaag 300
acttaaagtt actaggaaac ggtccaagta caatgcgtca cgtctcatct ctgctctccc 360
gggaataact caatatacat ccttgttatt tggtataaat ttttattatt atacatggaa 420
aggggaaagg aataagtgct tcttctaacg gcagttcgtt atctccatct ctgtagtaac 480
tacaacgcct ggatacactt atacggcatt tatcgcctcc tccaaaaggt cgaaccacac 540
gtccgtctcc cccattactt tattgtgacc gttgtccgtg ccgctatctt ccaactgttt 600
gtattgaatt actgatttga gcatagatac aaattccgaa cacttgccga cttactacgt 660
aacatgagga ccgcaccaga ggtcacatat tacagacatc tcatacacgg tccccacata 720
cgtcgcagtc tactgacttt tgtgtcaacc cttctataat aaattccaac ttaccgtctt 780
aatagttttc cgtatcttgt tagttactgt tacagcatca ccacactgct acatcgtgcg 840
aaggtaacac atatggcgca gcatcgtcaa aagaataaag aggacaatta atgcgcacag 900
caaacacata gtatattata ataagttatc aaacttacac atttcagaaa taattccgcc 960
aagccgtgta ctgattgacc gaggacgtcg agatcttttg tggaatcctc gcttcggtta 1020
cgtcccctga atttcgatat ggtttctagc catatatctc cgatcttttt cactacaaaa 1080
catcctccgt tgccctgtaa cgataacaga tggctttagt ccgctttact tcgaggttgt 1140
tataattaca gtcataccat cacaatacct ttattgcgtc caccacagaa ctatctagca 1200
gttgtacgtc cagcgcatcg tcctttgatt gctatataac agtaacagaa actattaaca 1260
caattaaacg ccgtgttatt gaatatcacg caaacgtggg gatcgcgcaa gaggacattt 1320
ttatacaagt ctgctcttcc gccattccca agcatgcatg atacagtcat acgtactatt 1380
agatggccat actcacatat tcgtctttca agcgttcatt aaagactctt cttccctccc 1440
tcagaagacc cgtcatccgc gaatccttac tcttacacct atcgatcgat aaagacaagg 1500
tatgatggct gaacatggca acgatagcac acgttaacat gcataacggc cttaatgctg 1560
ccattttttt tagcaactag agaagacaat tgttccctaa tgcctaccat gtgtgggtaa 1620
ctgtgccaga tggtgttata tagccacgag aacaatcatt tccgtatcat gacttactgg 1680
aatagaaagt caccgcttgt tgtgtttctc ggaagatgta ttgttctata taactatacg 1740
taggttcgtt ttcagttacg cttctcgaaa aggtgcacat ttctaatcaa acgactggcc 1800
ttttctgcgc ggccgcggcc gggagaggcg ttggaccatc ccgctcattg ttcaatagct 1860
aaatgactca tgtaattaag accagactca taacagacat gttatctgaa catcacatgc 1920
atcacgagtt atatccgtcc ggactggtat ataaaatgtt gcgagagggc gagtattctg 1980
atcttaccgt acagtacaaa aacactgtat tactaaaaac cagtttagtc atctcgtgtc 2040
agttaaaggt acttattctc aagtactcat ggaatctcat aatacgtatg gtcggtacat 2100
agatcatatt aattgcgaag tatgggattt gggtagacag attccacata atgatttaat 2160
gggatacgac aacactacag cacagccaaa tcgtccacgc agtacctcaa gcgcagctat 2220
atttgaacgt tcggtggaga atggaagatt tatggtagaa ggaagagcta atcgccgcaa 2280
tgaaacgttg tatgataact catcagatga cggaaggtca gccttttcct ggtccaaaga 2340
cccgtttttt gaaatacccg ccaacgatga cgccagatat gattctctcc catcggagaa 2400
gtacaatcca gcagaactgg gactaatagt ttttgcaggc actgaaatgc gtccagtatt 2460
ccgtacattt tttttaggtg gtaggaatgg taagcggaaa gccaagaatg ctataataac 2520
ggaaatagaa cgcctatctg agcagctagt taatgctggt ccgtcaaaca gatgtccgta 2580
tgtaatcgta ctaactgaag ttgaatctga tctagtaacc ggggccatgg catcttcaaa 2640
agcgttgcta aagttagggg gaatagccgt ttcgccagac gcattgtata ctatgttaaa 2700
acgactggtg ggagtaacga cttattcatc aattaagtgt acatccaacc tgagaagctt 2760
tgaatcgagg ccaacggtag ggactgtccc ataccgcttc gcattccagt ttggtcgtcg 2820
taagacggaa tgttacacac cgcgcgtgat acattgcgga gcggtttcat ttgttccgct 2880
gccgtctgaa gaaacgtcgg tattaggatc ggaggcgcta atgaacattc cagatcaagc 2940
aacatatgcc cgtactctta cagcttgtcg cggtattcca ccagtacatg attattgttt 3000
ggggctgttc ttccctataa agggaattta ttacttgtca gatggtactc gcgcccactt 3060
aggacagtgg tgtcagcggt ttttgtcgtg gttgcagtgg ggcgagggta gcgtgcatta 3120
tgaaaatctt cggaaactcg taccactatg tgactgtttc attagtgatg ttgtcatgaa 3180
ctgtaattat ttcaaatatg ggtttttgtt tcaccttcat tgtttaccgt gtcagcggcg 3240
cgagaaacta gtggtggaga tactacgaag ggctattgaa gatgcacaga aatataaatc 3300
cacttctaca tggtttaatg tctatagata taccagagat gactattagc atttaatata 3360
ccggttttaa cttttgacgt ctttcacatt acttaaataa aataaatatg attaaacgaa 3420
tcagtctcgg ctcttgactc ttgttttgag ttatagtggg gaagcagact atgtaaagac 3480
agtcgactga ctgccagtga acgctgaaca agctaggaca attacgagat tgtctagctt 3540
gttcagcgtg ttttattacc caaataccct gttagtagct tgggtcttta ctttttgcgc 3600
ggaacattgt ccagatatca tctacgtttc aatgaaattc tccaaatgta accaatgcaa 3660
ctacaaatat accattaaca caatagtgtt aactctacct ccaattcaga tcagactaga 3720
gcacttccag gcggtactgt tcgatcttta ctattaaaaa atcaatttct tatggtttta 3780
aaacacttta ttacattgta gtgtaacaag actcatacat tagctttgtg aattccacgt 3840
ttccgtattt cggtacataa tgcagcggct ctagccgatg ccgatacgac cccctgccaa 3900
caactcattg aaaatggttc tttgcaatga caatgatatc caaggccagt tatgatcagc 3960
acttccggtt catctatcga agaatccgtt tgtacacatg cgaaatatgg cgcgttgcat 4020
agacgatgct ccgtacgtat tccggcgacg gccatcggat cgttgaaaac tctgcaaaga 4080
cgtttcacgt ccccgacgct tggctcttct ttattgcata aaatgagccc gcagaagaat 4140
atatgtgatt ctgtttccat attgcattgt atattcattg aaaaaagacg ctgttcaaaa 4200
aacgacgcgc tctctagaac aacctctggt cttggtgtaa cacagtggtc cttcttcttg 4260
ggcatgtaaa acatctctat cgcatatggc gtcacgatgc gacttacgcg cggcatagtc 4320
cttacacaag tctcgcctcc gagagaatct attaccgcct tcgcgtcggc cattgttgtc 4380
ggtcacgtct accgcctcgt tcctcttatt ccaaccgcct ttccgaccta tataactcgg 4440
tcaataccgt tcgtattagc agcgtagcat cttataacgc ttcatggcac atgcgcaaat 4500
catgttgtct gcacgtacct cccactaatt tgcatgcaat gggcgttact atttattagc 4560
gactcattta aacacggccc ctcagaactg atcggtgctc cgcaacgaga cagtcaaagc 4620
gataagcaag atggccacgc agaccgaagg tccgagtacg ccaagagccg aagctctggc 4680
cgccatagat gagatgcgca gacgctcgag aattaatcaa tttgatgcaa ttataccaaa 4740
atggtacgtg ccggtggacc cgaatatgag cgcaccctat gctatcgtcg caaaacctgt 4800
tttgatgaca gcgcctgaaa aactacattc cgcgcgtctg actggttcat tcaaagggag 4860
acgcgtgact atagctgacg gatcgcggcc aatattatgg cggcggtcta ggtgtgaaac 4920
ccacgtgaat gatcttttcg gcggacaaat gggtaatccg acaacgcatg catggtttct 4980
gccactagga tgtccgtggt acgttgggaa agtggccttc ccgtatgaac tattaatggt 5040
ttttgccgat cggtgcactg aaatcattga agatatatgc aacgcggccg atgggaatat 5100
agaactgaag agtgtttttg agcttcatac aggtttagaa cccggattta ttaatgtaac 5160
gccatctgta ttatccgatt atacattcca tgaccgcaaa cgccacccta atggatcaat 5220
aatgctctat gatacagttg tttccgagtg gccatgtgcc accggtttaa ctttaccgtg 5280
cgtttgccat tcgcctggag gattgcaatg ttctactttc ctatctatca tggttaatgc 5340
tataaatgct gaactggcga atcctaagta ctcctgtatg caatttgttt attccgatgg 5400
ttttagtaaa agagtcgttt gggtatctgc gggaccgtcg ttattatggt cttttgagcc 5460
caaacgttat aaacggcacg aaaagacgcc caaatgtcta ttttatggtc gtataactga 5520
gttgaagttt ttgacaaaca aaggccaggg taccatgaat atagagacta ttgatgcgtg 5580
taactcttcg gatgagtgat aaagaaatta ttataccttc gtgttatctt tctgctttct 5640
aaaccactaa acgactatgt aaatcttcaa tttgtttatc tccgttcgtg agctattaac 5700
atggttgtaa aaaagacata tataaagaca caaaacaact ttaccgcgtc tgtgttgtta 5760
ttatagacgg ttgctcagat agaaagaaag aattatctct ttaattagta aagttaagca 5820
tcgaagatat ttaatattct attgccatca aaatgacgga aactagagtc atagctattt 5880
aaggactgct ctttttattt cttaaaacat ttcattacaa taaaagtact tcccgtgcaa 5940
aaatataggc gagattacat aactcgaata caatttgcac tgttggtcgt ggcaatcgtg 6000
caaatgttcg tctatcatct ccaagatacc agtgatgcac gctccgggta tatagcttct 6060
taataatcct aaaggatcga cgtcaccaag aggaatatag tccgatggtc gtttaagagc 6120
cctggacaac ttaacgaggg taatgaaaag aaagctcggt aggtcgacta tatcgccctt 6180
gtctcctctc ttcagcattt catcaaatga tctgcgcgtt ttcatctcgc ggcataagaa 6240
aatggggcgc aattttaact tcagattttc cagcaaagag ttaacagtcg cgacaatcgg 6300
atcgttagga atcaatggta ggccataaaa ctcatgcatc tttaaccatg ccataatctc 6360
atcgcatgac gctaatgcag ctattaagtc ttcattgcgc agaactgcag cccgcaggcc 6420
aatagccgca ctagatgcca attgtctaat ctcaaacatc cgcctcaact ctttcccgat 6480
taaacatagc gtatgccatg aaactctacg accttcgggt cctgaattcg cattatcaaa 6540
agatagtaca gatgcccatg ggtgttcggc ggttgttcgg aagcctccat tctgcactcc 6600
tcctgaaagt gtggcacggc atctttcaaa tatactattt atgcgttgct gaattgtagg 6660
tcggttaatg gctcgttggt cccggccttc gtgtgctggg cttgagcgtt gacttctacg 6720
gctttgttta aaatcacttt tatctgacat tcggcgcctg tctcggtttg gaggcgagcg 6780
gtcagcgtcg ccaactgttg cttcattatc agattgcatt ttagattgat ggcgctggtc 6840
gtgatcagaa ctacgtcgtt tattgccgtg atggccataa ggcgatccgt ggtttcgggg 6900
gctgtgtcgc ttagccctcg ctcgtttaac atatttccca gtatcatgat cggagggttt 6960
tttcttttca ttagcagtag ttccgcgatc ctcgtctgtc gcaacatttg gattctcaga 7020
cttgccgggc tccatagagt ctagtataat ccagtcgttg ctttgcgtct cggcagtgcc 7080
gtcctcgtat ttgttctgtt tgatatctgg ttttaaaccg tcgttattaa catttcctgt 7140
cttaggtcga gcaaacattt cctcgtccgt gtcgccagaa aaactattgg tctctgctcc 7200
ggagtcgtaa tccaataggc tcatggcatc atcttcatca tacttgtagc ctggggcggg 7260
tttagcactg caggccatga cgttgggcag gttcgttacc tctagtattg tttatttcta 7320
gaactttgtc aatctaacat ttggccaaac tatatataca catcaatatg ccggcccact 7380
tttccccaaa caccacacgt attacaagta ggcgtggaac aacacattta ttcaaattaa 7440
aatgcaaatt tatgcactga acaacatttc ctgtactttt ctctcatacc ataaaaaaag 7500
gaataccagc cctattatcg atgccaaatg caatagttta acaaacagcc cagacattag 7560
agttgcacaa caattagcac agactgacgt tagtccagac ataacacggg attgtttacg 7620
ttctgtcgtc tcccctacca ttatcttttt atctgtaggc ccgggggtca acattacaaa 7680
tagctctaca atagctacta tagctacata aatgcctgtt ataaccttaa aatacagtgg 7740
gtatgccgcg gcgcatggtc catgcagcgc ggaaaatgcc atcataacac aacattgagc 7800
tataccatgt gtcgttactt ctaataaaaa taaaactgca gttgtcttat gtcgtactga 7860
cgatgttatt gggtcattta caaatccacg gctgaaagat gatctgattg tagccaattc 7920
gcacattaag cgtgccatct tagaatattt acacccggca acgttgctcg ctattacacg 7980
tacggcataa ctaagaggat agcgagtggg cgaaatgaac tccttttgta ctctaaagac 8040
tccgaacatg cgacgatgct gtcgcataca tataaatgtg gcataaaaca taacagttaa 8100
ggaagcaaaa aaaaaatgcg ttgtccagat agaagcgacg caatttctag ctgcagatac 8160
aatacgtatt ctattgcgaa tggcttggtt gcgatttaac gaaactgctg ccgttttatc 8220
caagacgtca acaccacaaa tagcgtcaaa tttgttggtc atgctggccc cattaggtga 8280
agaaataaaa agttgtgtct cgttatacgc ttcccatgtc acattgagag cgccggaaga 8340
tgcgttttct ataggcgaga cggcgtagac gcaccaatgt cttcctacca ttccattagt 8400
tccaaaccat agcaagaaaa cagtataggt agtcgcgagt aacagtagcg ccatgaagac 8460
gatgcgtccg cctaagaaca ttattggctg gttttgctgt taattgctcc tcctatgtct 8520
acagtaaaca gggtatttag tttattgctt ccacacttgg tcgcgaagca ctgctggcta 8580
agtgatgcgc agaggcggcc atgcgcgtcg acgcttatcg caaggaatgt tctcgcagat 8640
cctttcgtcg tacgtgtatg tttatagcgc acgcaagaaa acccattgag atgtgagctg 8700
cgtgaaggaa tgagttgtag taaaagccaa tctgccttca aaattctaca gcgcgcgatc 8760
gcattcttat actcatgggc gtacccgacg aagtgatttt ccaggtagcg tatcaactct 8820
tctagaatga aacacgtggc aaattcctcc actgctgtac tatctgttgc acataccccc 8880
aacacgccca atgcctcaac gagagatgta cgcggggcga aaaacctatc gcggttatga 8940
ttagtctttg catcgaaaaa actgatatag tctccaccga ggctgtatat aacatgatga 9000
ggcatttcat tcacgatagg aagagaatga aaatggaaat tgcgtggttc gaaatggcca 9060
gatataaatg agttcacatc attacatgat tctggaacta cgatgaatgg cagtaatctt 9120
ccgacaatgt tattttctgt tgtcaccttt cccaaaaatg gtaaccgcaa acttctacca 9180
ttgccatata tacccgtgtc aatgaagtta tagtctttca cgtagatact tatggcttct 9240
gcgaatgagc gatcaagcag caccgcttgc tgtataagac gcgctatacc taccattgtt 9300
tttgaaccaa ataataaata cggcgttggc actggaatgg aaatgcgcat acctatcttt 9360
ttaacgcaat cacatgtaac gtttgatgcc accgtatcta aacggttcgt tagttcggat 9420
ttaatgtcaa tttcttcctc ttgttcacta cactcttcat ttggcgcgct atcgagcatt 9480
tcgaataacg ctgtttcgtc attatagccc tcaaaaccgc tgtcataact atcaaacggt 9540
tcatctaaga tatgcgaggc gtcatgatat agactagggt cttctaacat ctcataatgc 9600
tcgtctgtct ctaatccact gctatgctga ttgtctacat ttttacttgt ttttacacgc 9660
ccatcgttag tacatgcgct cttataaaaa taacatgggt aagaagacca atctacatca 9720
gttttaggca ttataagcga tagtgcggtg agcgccccct ttctaaaccc acgcatagct 9780
gtatgcagtg caatcaatgg tactgcttgc tttagatgca tatccacatc taggattata 9840
tttcctatcg ccaaggagcc attaaatatt tcattcctat ttgcatacat ctgctcgcct 9900
actattgatg atgcgatgaa tatactacgt tggttttcaa aactgctagt tacgatagac 9960
gttattttca tatcgactgc agctaagtca gatagcgata gttgttctct catgcccagt 10020
gatgtttgta ttaccggttc aaatgtatcg ttttttccag ttatgcgact ccatacatcg 10080
ccggttataa ttccaaatgc ctgtttgcca ttgggcatac caatcctata agatggtagt 10140
ggtatattgc tcgtcttgga accgataaat agacatgctg gcgccatagt tccggcgggt 10200
ggctctgttg ctgcgatagt tagtaaccgt tttacgatgc catagccgga gccctgtata 10260
ccaatctgaa attgtgatgg catccaatca ccttgttcat actgtaactc gtcgcaattg 10320
tcacggttgt atgaattgtc agaagggtcg ttttgacgat cccctgtctg gtgtaatgat 10380
ggggctgacg gattggactc tggccaacct cggcgaacta aagctgcctc caccttatct 10440
aatcttcgtg caatttgcgt tgcataatcc catataccga caacggtgtt gccatgggtt 10500
tgtttaaatg tatctttgtg ataagtcttt gagtttacat acatttttgc cagatccggc 10560
gttaaaacta atacctttgg caccacattt tgtttaatgt aatcatctat atttaactgg 10620
gctctaacat gtgagaagaa actttctaca gctcgttccc ccatgccaga ttttcctata 10680
atattcattt cagtttcctc aggttctcga actgtcacag cattaagatg attcgtcagt 10740
tgttcgcgat taaaacattc aaaatgtgct aaatatacat atgtaacaaa atccttatca 10800
gatatacgta aacagccccg atcattcacc aagaattcgc gcaaggctcc aacctcggcc 10860
atatctgcag caatgcgtcg ctctatatat gtggctagca tcgatgcgat gcgccctcta 10920
gcataattac tactacaaca gaatttcgaa aggagtgcaa acgaggtaag gtctgatggt 10980
acaagaccgg ttgggttagt accaacgttt acattgtatg ttccacatag atcccttatt 11040
gcctgaagat cgtaatccga acccctttca ccacattcgt gtgcttgtag taaatagtag 11100
cgcgttccca gtacaagcgt cttttcgtcg ggcccaaatt tagacacgta ccagaacgga 11160
gtaactaccc ccccgaaggc cctgcgatac gccgccagaa cgcgctgctc atgctgaata 11220
tataatgccg caaatccacg ttggccgcca ggataagtgc tcgttaaagc tttcacagag 11280
tttgtagtca ggggttcggc cgaatccgcg cttcgacctc ttctagaagt tgctccgcca 11340
aacgcaacat aaagggttac attcagtgca tgatgaagtg catatgtagc gtcttcgatt 11400
aatgcctctg ccactatttc agaacttaac ggttttccat gcatcaacgc tgcatatata 11460
gaacagagtc cgcgctcggt cgtaaagcga catacgaaca tcggtctcac acgatcctta 11520
cgtgcgttac cacaaacacg attcggacat ggcaaacaaa aatctacaag tattgacgat 11580
atgccctctg gtggagcagc aaaatcttgg cacgtttcat tggcaccatt tgacccatgt 11640
tctagtattg atctaccgct ttcataataa ctgacaatat agatatcgcc caaatttacc 11700
tgcccggcca ttagcatgag tgaatgggtg atgacacacc catcagttgc atagaccact 11760
cgtatggggt cgttttcgat gctcgctttt acaaaatcca tatcatcttc attgtcagaa 11820
aaatcgaggt tgacgtcctg tccttgcaca gccattatat ttaagagcgt ctaaaagtta 11880
ctgtcaatca tcagaccatc agtatcaggg cacgcatcca cacgaacgcc taatcgcgtc 11940
acgcggtagc aaaggtatat agagctctgc cgggaagatg tttttccgtt tggtttgaag 12000
acgagcagtg tcgtcttctg ctagattgaa gacgagcgga acatatttcc tttgtgatac 12060
gaagtttggt ctggtgaaga agcagctgat tatgttagct tttatctcca gcatgtgtgg 12120
tctaaggcgc ggggcggaag aaacgtatga gcctgtctca atgggtgtgg cagatgggcc 12180
atctttgatc cggctaaaag aggccttaga aaacgtcaac gctatgctac catcgccaat 12240
tacgctggaa gatgcagtaa cgtctgcgga tactataaaa cgtctcgcca gaggaaatac 12300
gctcgcacga acataccata tatgccagcg taatttagaa tgccttgcaa aacatactcc 12360
taatacagac aacccaggac tggatgcagt tgtgaatgca catcgcgtta ataacaaacg 12420
cgttgctgat gcatgtttcg cctcgctaat gcaactatat atgtcggtcg ggtgttcgga 12480
tgtgagtgat acactagtgg acggtgcaat taagatggct gcagaaacag aactggtgat 12540
ggcagatgta gctgttgccg agaaagccct cggtcttaat ggcgcacaaa acgaggcaca 12600
aactgagatt attggaaaac acgaagccca aaagaggcgc gctccaaacc cgccggttgc 12660
ctcatggact gaatgcactt ctgaagatca gccagacggg cctatgcgca aatcggtaga 12720
gtatgcaact atcaagaaac cgccgcgtgc aattgctcct tccccggcac cgcgtatgtc 12780
tgttgccaga gataaagcca ttaaggagaa acccgaagag ttacaaacgg ctacgttggt 12840
agccgtctaa taagacctat ctaatatgaa gaggttgtcg tactttaaat aaaaagacac 12900
acaaaatgta cttttgcaat ttatttacta ttgatctttt aaagtcaata aaggaaaact 12960
aaaaagacgt gcgatttaat gttttgtgat ctgtttgaca ttatatccca gttgatccga 13020
aacctccttc tcttctctcg cttgtcatag cctccgtgtc gtagtgaagg gtgaaacgcc 13080
aaaccggtga tggatatgtt acatacggag cgcttgtcga cagcatggca ggcgggcatg 13140
ggtctgaata gttgtggtgg ggcgggatcc atagattagc atcgcgactt atcagaacta 13200
actgggcaac acgatcgcct gcatttagaa acacggtctt acgagtaaaa ttgtagatga 13260
ggaacgttaa ccattctccc tcgagccatc ttgttggcaa taccgttaag ccctttgcat 13320
tcatagagga acgcccaaat atacatggca agacgtcgga cgtcttgcag ttataaattt 13380
gacgtatttt cacctcggta aatgttctag gctgtaattc caggtctcgc ggcaacggta 13440
tatcatatcc agcatcctct agtcgtttac gattgaaagt gtcaaaaaaa ggtcttaggg 13500
ttgacatttt cccacatgaa gaaaacataa tgctaggttt ggcttcttta tcatctggga 13560
ctttgtataa ccccaaaaca acatatcgtg aatgctttac cgcaaacgat acttgtttgg 13620
ggtcggcgat atattgtgta gtagcggctg ctgcatcact tgttatcaca accatggact 13680
cgcattgagt cccgggccaa atctttgcgt tatctggtgg caaacgtagc agacttaatt 13740
gcgtttctgg gctacagttc actgtagcat cgcgtacgga ttcgataaat ttgccgccgc 13800
attcgtaata attactcgca tcgtagaggt caaacaaaat cctgcgttgt atttcctggt 13860
cgtccgatag tttgactaat gctagtcgaa cgctcaatgc atttgggggt attttggtta 13920
tagagccatc gtaataaaca actaagcgga tggtgccgcg gtatcccgca tcgactacgc 13980
cgttggcgat ccgcaggaaa ggagaaccgc ctcctataga atctgatgaa aggaggagcc 14040
ttgtcaccaa aaccacataa ttgttaggga aggctactcg tacaccagtt tctattagag 14100
cgacaagtat ctccccagga cgacagctgt cgggcgtgtc tatagcttta gtgttgtcca 14160
gacggagaca acgcggatcc gtcctatcca cgccacaaaa ccagtatccg ccctcaccgg 14220
ttctgtcgtg ggaaactata gcttcctcca cacagaagca aactggtcca gtcggacttg 14280
tggattcgtt ggagcgcaga tcttgtataa cgcgctttgg agctccacaa tttccagttg 14340
ccatggcttc tatggagaca gcttctgtgc cggctacacc ctcctctgtt atacttatcg 14400
ccgcgttgat aatcgccgca cttataactg gggcgcgtgg agaacaagag ttcgaagaca 14460
ctttctggtc gcccagatgc tctgccgttg gcgtgtcagt tgccttctcg tcaccctttt 14520
ctctgatgtt ctacgtagct ctaggcggtg ttgccgtttc cctattggct ggcgcttacc 14580
acgcctgttt ccgcatgttc acaaaagaca tgtttagggt agattggtaa ttacatagca 14640
ggatttggtc gtagcggcca gatcggtata taagtcacag ggcggcagct actggtcatt 14700
gttgcgtttg gtggtttgtg tgaaagttct acgctttctt ttgtttttta actacgaaat 14760
ggcaaataga atagatcgac ggcctgagca ctctggtagg aatcatcgta atgtgtatga 14820
ccaatatgat ttagacgatt atgactatga cactccagaa gaatactccg accctggaga 14880
ccataaacca cgcagacata gagccgatgc aactaccccc catgtaccaa ctgccggaga 14940
agcaagacga cgcagcgtgt ctataggaag atcggctgat aagcaatctg gaaggcgcat 15000
ttctgcggct agctcttcct ctcaagcatc gaccgatagt tgcagacaac gcgcaccacc 15060
tggcgctact accgtgctaa agaaatccct ggctttcagc aatactcccg aaacgagtac 15120
aactcaatgg aagacaagta cgatctcatt caataagcgt atattttgcg aggcaatagg 15180
agctgtcgcg gcccatcagg ggagacttgc tgcagctgca ttatgggatc gccattctcc 15240
gcgcaataac gagagccttg acgctctact ggaaatagct atggtcaaga ttactgtatg 15300
tgaggggtta gagctgttgg agattgccaa tgaatacata aaggcccatt cggatgagct 15360
ttctggccag acccctcgtc aagcggcggg acggcgggat gacggtcata ccgagactac 15420
gggccgtggc cgacgtagtt ccgttgcccc ggggggaaaa gacgcacagc atgcaagggc 15480
tccgtccagc caccgtaaca gttcaagaag accacaataa tttgaaacct aaacaagcat 15540
cacgagtgtg aaagtgttga tgacaaaagt gccaaaattg ggtgtgagct gtgtataaaa 15600
taaacctctg aacctaaaaa ttgcagttct cctttgtgct ttttggaggg aggaccgaat 15660
agttctatta acgtgttcgt attattaggt aaataggtgt gggtgtggat atggatacat 15720
ttgatgaact cgacaggcta ctggctaata ttgacgcgta ttcagcaatg atggcagatc 15780
taagtgtaga agagcagcgc tgtgcgggtg aaggttatac tgcacaggcg acggacttaa 15840
gtgcagaagg aaggagcttc ttggacgacg tttatactac acagatgaca gaactaagct 15900
tagaagggaa gcgctttata gacgacttcg acgacacctt gttagatgat acatctatgg 15960
gttacgctaa tggtacgaat aattttaaat atccgtctgg cgttccagtc tcaccggctc 16020
agttttcaaa gcgcatcgcc ttacccccac cacggccgtc ggcacctcga gtattatacg 16080
tacgtttact gcgcgaactt gaatttcctg aagcgtctac aatactatca acatttgaac 16140
ttatgaacat ggacttattc tcatgtttgc cccgcaacga agacctttat agaaatgctg 16200
ccctactatc gggatctgtt acagaggtaa tagaagcatc tgagattcct atagacggag 16260
aaatagactt aaatgcgcat ggatctaagc aattacctat accgccgtcc aatgaagggg 16320
aaataccgaa ttatgttgaa gcagtgcaac agttctttct tagtgaacta cgcgccagag 16380
aggaatcgta tttgaagtta tttctcggat actgtagagc tatagtaaac tacataaagt 16440
cagcagcaac caggggcgtg aggggctgta gaataatgga tcggaaatct gaagcgaaca 16500
agagaatgcg tcgtatgatt gcggatagat attacaggga agcagcgcgc ctggctaaag 16560
ttctgtactt gcacctatac ctatcagtcg cgcgggaaat atcatcacga ctatgcgcga 16620
cgcagatgca agttcagaac gtctttgtct atatgcgata cgaatggcag caatatagac 16680
aatttacatg cttatttcat cctataatgt tcaaccatgg cgtcgtctta ttgaatggag 16740
aacctctcca ggcgcagaaa ttgagggaag ttaattacat acggttcaaa cttggtttgc 16800
ctgtcatacg ttgtggactt gtcgaggaac atgataaacc actggtcgaa gaaccgcgtt 16860
tttacggcaa tttgccacgt tcttccggat ttttgactga actaattaga agcaagatgg 16920
aagcgtattc agagcttcgt ccaacaagcc cttctagcat ttctaatgac catacatatg 16980
ctaaacaact tgataaagtg aactttggaa gcacccgcga agcaatattg gatactatag 17040
acaccgaggg accgttgcca ggggacccta taccagcact gtccgtttct gtcagaaatt 17100
taccagcgga aacgtcgttc tcgccagata attagcctac ataatagtta agtacatgtg 17160
actaatcacg agatccaatt attcaatgct atttgctaac gaattaaata aacgcgtaaa 17220
tcacatttca tacgtgttct gttatttttc gtttctaaag tgcgcgggtg acaatagcgt 17280
tgttatttgg agcgacgcgt cgcggtaact ttatttgttc agacggctcc agagccgccg 17340
cacctatcaa ggttaaaaac gttggtgctg tatagataat tttactagag aaaggaggat 17400
tataggttca agtagaatgg ataaatcacg aagacagcgc cgtaggtcat caacgcccaa 17460
tgggccaatt aggtcggcca ggaaatcgga ggatcgtaga acctctaccg atccttacgg 17520
tgccggaacg tcaaggagaa gtggtaagag acgtacactt gacaggactg aactgcctaa 17580
ttattttgat gaaaacgcca gacatggatt tgagtctgac gatgatgaga tcgtaactat 17640
ggagttagat tctggtagcg ttgagccgcg taagctttcg aaggacgccg caggcggcct 17700
gtggcaattt atcagccatg cctttggcgc gtcctcctct ggctacgagc aacatcaagg 17760
acatactagt tcatcggacg atgaatacat agagagaaga cggcgcatta gaacttgcag 17820
agatgtgccc atagaaaata cacattctga agaagaagac attagtgaca atatatcacg 17880
atctaggcgc gagtcatcta aacgggcgcc agtacttgac aaagctcctt cagtacaaac 17940
tgaatctcgc ccggcctaca gacaccgcct taggatgggc gataggacag atgatacctt 18000
tttaatagga cattcagcat catgtaaatg tggttgtaga gatagagact cttgtttact 18060
cccaaacgaa caggtaagcg agaacgatta caatgacgaa atggacagcg ttccaatgga 18120
agacagcagc tctagtggga cacggtcaag taggcggttt gttaaaccgc gtgaattagc 18180
tctagaggag accgaaggca gtcttgacat ggatatgttt aatcgatacg aagccgagtc 18240
atctgatagt catacgttat cgcctaagat gttgccatca ttagacggtc gtatattgct 18300
tggagatttg ctcaaccgtc taccatttac agaattaatt agtcctgtta atccggcaat 18360
agttttagga gaggacagat tgttttttat gaggaattgg caatatggtg acgtagtcgg 18420
atggattaat aacaagagcg acgaaaacct accaggggct atgtattttg gacgtccgac 18480
aataacaggt gcaatgtacg agcgtacgtt gatacaggca tatttactag tccacagttt 18540
aactgatgag tcattacact attctgtgaa agcctcggcc attaccgctc catcggcagt 18600
atttttccta ttagacgcgg ctgtattagt ggcaaaaaat tgtcatgcca ccattaggtc 18660
actagatcgt ggaagcttac tgaagcagct accaggacat gtatcaacgt tactgcatgg 18720
cggcccagta agtccagtta atgggccgac tgctgctatt atacgctctt catatggatc 18780
ggctctttat tggcccgaca tacgtgctgc gttcgaaccg gtagtaagac ctatatgtag 18840
atatgctctc gttaaaatgc tcgatgggga cgtattttta ttctcagtct tcaacccact 18900
ggacaagtct gcgtcagtaa atgagttgcg agtagcctcg ctatgtctaa ctctaggcac 18960
aatggccgct gaggcaatgg tcagacttat ttatcttggc attgggcgtg cattacaccg 19020
ggatggcgat gataaagtat tccagagcat tacagaaata atggaaacga gtcttttccc 19080
cctcggcacc gagcttgctg ccatgattga ggaagatgct ttgtatgata ttgatggagt 19140
gcacatagag gacattccat ttgcaactgc ggcactaaat acatatattg cagttcgttc 19200
gtcagcaacg gagttgcttg gagaacatat agaggcttat gggtcaatcg aaagttacga 19260
tgttcctgca actgccatcc attgtatact ggcgactaca gttgtattac aacgttactt 19320
agggcacttg aatttcctac tctgtttcat cgcccatcat gcattaaatt gtggtattgg 19380
aaacattact atacgcgaaa acacattgtc tagatacaag tggttgatga cagtcacgtc 19440
atcgttatat agacatgtta ctatggaaga atttttgaag gattacgaag atgcaatgag 19500
ggaactttct atctctccga actctcatac accatccgga cgcggtgagg gaacaattac 19560
aattctccca catacaccta cactggattt actacgcggt catggaaatg gaagagtacg 19620
ctccagatcc cataagtatc ttggtgtctc cgttccgttt gaagaagcta tcaatgaaca 19680
gcgaattctc gtacttggca aatcaacatc aaaagcatta aaacgacgtt tgactggtgg 19740
gagggtacca aaatctgggc ggagagagtt acattaaatc gtcaagtacc taggccatat 19800
aactagatac tattagttcc acgctcaata ttggctacgg tgatgtcgtc cagggcgcca 19860
tcatactcct tgcgtatccc tgaattacgg agctcgcgat gtggactatc tgggagcgat 19920
ctaatagcac gtaggctgcg cgaaggctgt attattcata ggccccagga tgtatcttta 19980
tcagctctac gagcattgga ggcggaagcg gagaaaatac taccatttca gctatttgcc 20040
acacaacgta cggaggtatt actaaaaaca agatgcaaca acgtcccgga gtctataata 20100
atctcgaatg ttatgtccga tacgaacgga gcgtacataa gcaactatgc atccgaagcc 20160
aaagcgacta taaaggacac tggattaaat aagggagctt cgtggagcgt tatattggca 20220
cgttattgga aatatctccg ccacagcagt ggtgcagaca tcgtcgttaa tagctcaaca 20280
tcaagtacac gtgcattgtt ggggaatgtg acacctatac ttatcctcag atctacattc 20340
gagccaaaac cattatctaa acgaccactt aaggggaaaa aggtaacagc gtcttatctg 20400
gaacaattaa cagaactaaa gtctaatttc gacttagtcc aacgatacat gttttacatg 20460
cgtccagaag atccgatgca ggctagcatt tcaacggaca tacgactgag ggaaattatg 20520
acatataaca gtatactata ccgctggatc ttatggttca tggatttatt tgacagtaac 20580
gttctgcgcg caatgggata tgtaaccggt accaacggtg cgagagaagc gcgacagcct 20640
gagatgcttt ttggaagaca tctacgcagt ggcccaggcg caactgatac atctggaaat 20700
gccgtcgctt tgacttggtt tacacataat gtattatctt cattgctgaa gataagtgtg 20760
ttatggtcat cttcaaagtg gcatagtgga acaaatggag tgtcatctgc catcgttgca 20820
gcggttgaac ttgttacaat ggttcaccat cattgtcaat atctggttaa tatgattatg 20880
gcaggataca tttgttggat taagggcggc gcgaaggata ctgttttaca atctgcattg 20940
cgttcccaag gacgtttttg ccactttatt ggcagactag cccctacgat gacagtacat 21000
tcgtggtctg aaatggaaaa gggaacgcga gcgtggttca aaatggctca cgctcgctca 21060
attattactc atggtaaacc aactaaacac tatctaacca cagtagggtc agttgatgac 21120
ccgtttgcag atacggtgga taactccgac gacgatgaca cagaaactct taacgatgga 21180
tatattacac gatatggatc atccatcgta cggtcatcga gagcgagtgg acctggtggg 21240
ccttatcgtg gaatactggt caaacaatca aagacggata gtgaagaaga tttgaatcca 21300
tatttacata tggattcgcc caaatcgcct ctgtctatat cttcttttaa atcaagggcc 21360
aggcacaggc gcacgtcttc gtcatcatct actaagacaa cgcgcaatga cccctcatac 21420
tggtttgcag acggcgataa tctattcagc gttgcatcga atggtcatgg acgtattcgg 21480
gagaaaacat attcattaaa cggacaatta aacacatcaa cactcgacgg accactttct 21540
ggtccgggaa ctagcgctga tggagaatat gtagatatgg gccagggggc aagtcgaagc 21600
aaaaactgtg cttcatgtga tacaactacc gctaccacca agacaaccta ctcggaaaac 21660
gctaaccatt gcttcgaata cgagactaat aacgacaccg caacgggtcc taaatgcgag 21720
tcaccagacg atgtttatga gactatagaa cgcgcttcat ctaactacag ttatgagaat 21780
gaaactaagt ttgcaaccgt tgcttctgat ttgggaagga atcatcgttc aatgtctaga 21840
acgagttgcg cttccccaaa cgtgttgaat tcttaccacc acggatcgag aacagacggc 21900
ggctcgcctg tacaattagg ggacgatgaa acggtgcaat gtcaagttgg agagacgacg 21960
gcggcgttca gaccgcgggc atattgcctc ggtaaacgtg atcgagagcg cgaactagct 22020
gcagtgcagc gagttatgaa tagactgtca tttgggaaat aattgatggt ttggcgtttg 22080
gtttatacaa acataagttg tatcctactt tttaaatctg gtttatacaa acataagttg 22140
tatcctactt tttaaatctg gtttatacaa acataagttg tatcctactt tttaaatcta 22200
acaaattggt aataattgat ttagttttaa ataataaaca atctgattca tccaaatctc 22260
gagttttgta gtaattttat taagatgggt agaaacacgc atacaaataa caagtcttac 22320
gacaaaccaa agacgcgccg gacatagcga aacattccag ccacagagcc aagtggtctt 22380
ggtttctgac acacagtcgt cgcagtttgt gaacaaatat catctttggc gccagctgca 22440
tcgattctta aacaatgtag tccgttcaaa ttcgtccaaa ttggggggag gctttctcca 22500
attgacgtat tgtttgcata ttcgccgatg gctgctagta atgtttttgc attagcaacg 22560
gtaattggtt cggcatcaac ggccgcgcat agtcctatga cgtcctttgc aatagtatta 22620
agcctgacgg catacacgca tactgtgtct attcctatcc aaccgtggtg acaagtgctc 22680
gtatcccacg ctgtagtcgg tatcgcaaat acgccgacaa aaaagcatac caatccgaca 22740
attaatatac ccacgacaat accgattgtg attaggcgtg ctgttttagc acacccaact 22800
ccatggcggt catagcaaat tggccgcgat ctttcctctc ccaaagacca gctatttcgc 22860
cgcgtgttaa ttggctcgcc attaccaaaa ttccatccgg tttgcggtac agcactttcg 22920
cgcggttcgg agactgaaaa ctcgtctcta gaatgcacaa caagttcttc ggccgacatg 22980
ggcgccatca ttgttagggt gatccgcccg caatacacgg attagccaga tggattgatt 23040
gacgggcaag tgtccagtta tgtatcctaa acataaggtt taatcgatga gttgtgtgat 23100
gaattagcgc cacaacggtc ggtaacgtgt cattctagtt atttagtaat attatgattt 23160
aatgcgtcag attatcttaa taatggggtt ggaaaatgac atcactgatg aatggcctct 23220
cagtaatgtt gccccattat gtatatttcc accggacctt tatttaaagg ggcagtgtta 23280
tcaccaaagg acatgtcaaa gcaagggaga acctatcttt tacgagagtt taggttatct 23340
cgcctcgctt cgatatgccc aaagcgtaca gcattcattg ttctgcttgc gaagaatgta 23400
tttcgccgat tggctgtgat gcggatttaa tttacggacg gatgcttaga gaatttgtaa 23460
agcgacaatg gccggtcaat tggttcggga aattaattac ttcgtgtgta acacgtaatt 23520
cgatcggcgt cagcggattg gtggcgcatt tttcgctaga gaggaacgct gtaccaatgt 23580
ttactacatc acgcgttcca tggcaactca tcaagaaaaa tctatcatcg cgtattcgtt 23640
tagctgcatc ggaagaaaaa cgtaagttaa gaaacgagcc gtactgtcct tggggggaca 23700
attattcaat gacacccgta ccgcttggcg gcatagacgc ggcgttggac atacttcgac 23760
gcggtccatc agcgcatttt acgatacaag tagattgctg tcctatcagt ccgtatatcc 23820
tacaattggt cgtatttaat ggccatatga ctgcgctgtt gcatgtggat actatgcacg 23880
tcagcgataa atatggcatt ggatggctat tgaccgaggg cggaatcttg gcacattatt 23940
gcgcaaagcg acttggcgta tttgctgatc gtttagcatt gctgatagga cttgcaatcg 24000
cgtctagtaa acgtgaatgt atgcgcacaa tcaaagcgac gatgaatact actatggtgg 24060
tatacccaaa ggttatcttt aggcgttttg cccgttcaat agacgattgg agaacaaacg 24120
atgtaacaat atgtggctat gattcctttt gttcggatac tatatgaagc tttggactga 24180
atgtgccgaa caatctgtat agacactgcc ccatcatttt tgaagttgtg ctatctataa 24240
actcaattaa tttgaatgac tgtagaactg tgaagcgctc gaactacact accattgtta 24300
gcgtcccgaa tataatgaat gctatttaaa acgtcgttta tttatcaaaa gctttattag 24360
acattttata ttaaaccagt attcaaataa tattgtctgc tttatctcgc gaataataga 24420
aacaaacggc cataattaat attatcccgc cggttaaaat tccagccgtt aaaactgtaa 24480
ctatgatcat gatcataggc ttcccctcgg aataggggga cgaatcataa agggccgcat 24540
cttcaaatat aggcagttcc tccggatagc cttctacgcg acatgtgtac tgtgtcaccg 24600
tgccagtgta ttcaagcggg taacgagatc taatattgac agttccggga tgatcgatgc 24660
attggcctac aacttccacc attccgtcct tccaaatgtt ttcttttagc tctcttccaa 24720
ccatccattt aattccaacc gcagctgtgt cggcgacgca tcttgcatta catactgcat 24780
ggcccgattc gaatgttaag ataacgtttg gcttagaata aacaaccgga actgctgaag 24840
cattaaatgt tcgcgtctcc ccttcgccat tccatatagc tttacatgtg atctctgggg 24900
gcatagaatc aatagaactt ccgagaagaa gcgaaccgat caaagacact gtgtcttctt 24960
cactttttgc ggtagaataa gtccgcactg agtttatagg caaattggtt gaatcatcaa 25020
ctacccacgt catacggcct gagccggggg ggaaaaaatt ttctaatata cacgttgccc 25080
gatatcgttg gccataaacc atcggatgag caatgacaga gatgccggat ggtatcttta 25140
taattttcag tgttattgct ccgattgctt ctgtccgtct ttttgtctta ttagtattac 25200
tttcaacaaa aggcgtagac aacacccatt catacaatcc ctcgtctaga gcagtcggct 25260
taaggatagt caatggaaag ctagagtctt cggtcggttc aaacccataa tgtttttcat 25320
ccagtccatg caaatcgtat tcgcctaggc cactatccgc attacttggc atcgcagtat 25380
agatgattct aggttgagct tgcttagaac cgacgggatc atactgcatt ccgttccatt 25440
cgactggaga caataaatcg actgcttgtg ttggtttgtg ataaaaagta acgaccattg 25500
tccaattctt agcattggtg gcatttcctt taggttcgca tccgaatgtt atcttttccc 25560
catgatatgc cagttgtttt gtcgacgaac atgtcatctg tgcggcgttt tgcgatcttg 25620
taattgttat tgttaacagt agcgataccg agaaggcaac catcactaat ggccccatga 25680
tatagaatcg ttaagtattg ttacaacttg atgatgtacg aaggatacac cggccgaaga 25740
ctatgtgcgt cggctaaatt gggaaaaaag ctcaacacga cacttttata tgcaatccat 25800
gtctttattt ttaacgaatg ttataccgta ctgttgcagt cagtgttcga tagtaatggt 25860
tttattcacc gacggacacg ctttttatga gctgtaagtt acagttagta acccatttgg 25920
taaatacggc gaacgtaggt aattccaaga cctagcgcga ttgaacaaaa aagtaatgca 25980
aacatgctac gtgctactac tgaaaatgcc agccccatga gtccaacgca tcgacggtgc 26040
agcaataata tacacaacgc tacttgtgaa ctaacggaaa atacgtaact atatattagt 26100
tcctcataac ctctagtcac taatatggta gagataacct gtagtagtat atatgttatt 26160
ataagtacac gctctacata aatggccatg gaacatgtct tatgtggtaa tataaacaca 26220
tttacgagat gccccaacag aactgctaat gcagtagtct cagttaactt aatgattggt 26280
atcgtaccac catatgggaa ggtaagtact ccgtataaaa acggaattgt taggattgaa 26340
aatagtgtat aacatgaatg tcttttccgc cgtttaagga catcaaaaat agacacgtcc 26400
tcttcgtgtg ttccaatgtg cattcgaggt agtccatcgc catttggtgg aattgaagcg 26460
ggctgaaatg ctactccgaa acccatatcc gcatatgtcc tcatcatagc aaaacgcgct 26520
aatttgtaat gacatgtgtc acgcattttt gcgccatagt ccttcaaaca gcccaagatc 26580
attatagcgg cgccaaaccc aatcgctatc cacacattac ctctaattaa tggggttaca 26640
attcccaaag aaatgccaag agaggcacta ataaatgtag ctatcatatg cggcggtgct 26700
ccggtcgcgg cacatgaaat gtagtatgcg aaaactggcg taccgaatac gacagataat 26760
actagcgccg ttacatatgc tatgttaaac gcatgcatgt tcgagtcgat cggtatctta 26820
ttccgcaata attctgtctt gacctccgtt cttgtcagtc ctataaccaa ggcggaaata 26880
catgccaaaa tttgcaacaa cttaaacgtt aggcacatca ttttcataaa ttttgatgag 26940
tatcgtaaaa tattaagtat tgctatagcc aatagcgcaa ttgtggctcc ggccaacgaa 27000
atgcgattcg ttggcataag aattgttgtt gtacatgcag caatcatagc tgcatgaaac 27060
ccgatcatga atacagatat agtagatgcg attgtacatg gcccacaacc atctcgcgat 27120
gctctacatc tcgatataga actagatgtc atcaactgtc tggacccatc ggtcaatagc 27180
ggcgccatcc ctgtatttgc ggcgatcggt gcttgcggta tagcagtatg cccatttctc 27240
tctaaattca tgctgtatgg aggtagggtg catgcagaat tgccatgttg gctcgcttct 27300
tcgtaaggag gcggtggcgt tcgcggtgtc tcgccggtcg tgtccgtaac cgtaggctgc 27360
acttcggcca cgacaggacg ctccgtcgcg ttcgcctgct cgctcattct aacgctattc 27420
tataatctta tacaagagtt tatacgagcg ctagagacgt cccatttgaa tgaaaaatag 27480
tctaagaata agacaagctc cagacaactc tcaatttaac tcttttatta caaaagcatg 27540
tatttacata ttagtcacca ccctcattga atatgcgcaa tttacatact gttgatatca 27600
atctccattg taattctact caaagtatat tataggtagg gcttcattcg ttttgcattt 27660
aaacagttat gttgcaggcc agtgtccttc ctttttctct gcactggcaa gtccgttatc 27720
ttattaagtt tcattgttcc atcgatggca caaacttcct cgatttcttc tatcgaaaga 27780
cactcatatg tgcagaagaa aaagaatgat gtgcggcttg gttcgtctaa gcatactctt 27840
agcatcggtg tttgggtcga cgtataaaag gccaatgtaa aaccagatga gaccgacttc 27900
actttctgca tcacgctgtt gaatgcttta atgtcaccca atgccataca gaatggtttc 27960
ccggatccta ttccatataa gcaatcggaa cgtgcacgtt ttgtcacctt tccgatcaag 28020
gccttagtgc tggaagtcgg acgactaaac ggataatcat ccatatccac gggcgttatg 28080
tcgaattgaa ttatcccata catagtacca atacacaacc ctccctcagg cttcaggcaa 28140
aataccaact cttctggttg agtcttcatc gaaagtccta taacacgttg aaattgtgac 28200
ttcgacagcg ttacggtcgt atcggcattt tgtgaaggcc aaaaacaatt atacgatacc 28260
agttcgtatt taacgtttgt catatcccag acatgtccgt cgctgacatt tttataggta 28320
attgtctggg ccatgtcgcg tgtagggtac gtaccatgga agttaaattc caccctcata 28380
acttcttttt tcttgtctgg cctgaatgcg tccaacagag ttttgcgacc atctactaat 28440
gccaaaaaca tagctgccgg tccgttccag atatattctg aaaacttggc tgtagacagc 28500
ggcacgaaga cgcgttgtgc ctcaaccgat gcatgtagca ttactccttc gggcccgaaa 28560
gacaggaatg gatcctttac tgtactcaga aatggcttca gcatagttat catagcatgc 28620
aacttatctc catggacgac cacctttgta gcagttgggg cagatgccga tgtttcccct 28680
tcgtcgtcat gattttctgg cgtaaatttg ggcgtagcca ttattagaaa cccttagaga 28740
ttctagtagt ggtagtagca gatgcgatcg ctgagatgcg atgtatacca atagcgaatt 28800
ccctctcaat cagccgtctg cggctgctcg cggccccaaa agcattttcc gcgggtttta 28860
taccacgcgt cgttacccgc atgaaatgta ggcggaggcg cttaactcga attcgccgtc 28920
tgcgcaagtt ttgcttcata agaaccaaga agtctcatta acattttgta ctgagaggcg 28980
gacagatggt tcccgaatac tagatagtgt ccgatgaaaa tacatgagcg ttttccatat 29040
agtcatgtat ggcctagata gtgaagcaca ctaatcgggc ctgcgcactc ggacgaatgt 29100
tctagaacat ggaaccattt aaactacaat aactaattga atatgtgtat ctctgtcaat 29160
atatgtcgtg gagaaatgct actatatatg catattacaa aagcaaacgt aagttaacct 29220
atattgaata aagcatgaag tcgacgatga gccgacatga tgaaatgagc ttactccatt 29280
aggacaactc atccaacgag cctattatag cgccgggcaa ataatcgacg gatagatttc 29340
ttaacgcacg ccaccgggtt cgaaacgtca tgcgcatatt aagtacttcc tgttttgtcc 29400
caatggaaag cgtcgtagtg ttcgctttcg aaacgctttg ttctcattag ggaggaggaa 29460
atagaaaagc aaacgcgtct tacgtacatt actaggtact ttattcttat cacggaccgg 29520
tagtcttagt attcgctttc caactctggc tatttaacca tccacattat atctaggagg 29580
actatcaatc tggccggcta tttgaatcga tattgcatac gacagcaacg atacgattcg 29640
gctgagaact gcgccattcg gttacacggc ggccgttacc atttactgcg cgagacacat 29700
cagtacggcg atccgattac gggacaacag cgccgaaacg taagacgaca atacaatggg 29760
gctgtatggt tgtataagct ttgcttattc gcacggactt gtgaagaagc aagcttttgt 29820
aatgccgcct ggtgtattga ctcccgttgc cgtagatata tggaatgtaa tgtatacgct 29880
aatggggaaa ttctattctc gccaggtcga ttgcgacgac agcgcgctac taaacgttaa 29940
atgcttgtat atggttctta gacttttaca taagcgatct tgttacccaa tatttgtttc 30000
tgatcgcgcg tattatttca acaagaaagg atgtaaaggt gctaaagcaa tatttgccag 30060
tactatggca gccgaggggg gaaccggccg gcttggtaga tttgaggctt ctctggatgt 30120
ctggctagat gaggatgaag cattagaaac tgcatgtaaa gatgaaggag ctatcatttc 30180
taatggagaa ttagcgcccg tcggtacaga ttgtcaatcg gatgaatgcg tacaggaagg 30240
cgatgtatgc caggagtatg aaataatgcc gagtctggtt aacgacttaa ataatgacac 30300
atcttacaag caaggtcgta ttgtgacaca aaagcctaag cgatatggaa caagacctga 30360
catgcccaaa ttaaaccacg gaatatgcat gagtattata aaaatgctcg gctttccata 30420
cgtggatgcg cgttccatgg aagcagatga tgtttgtgca aacttattcc atacaaagac 30480
tgttccatac gtatactcta atgacggaga tcttctattg atgggatgcg acgtaatact 30540
agatatgagt caaattttcc ccccaacgct tcgctgtaaa gatatattaa atgagatggg 30600
gattgactat gctacgtttc tagcgaaatt tgttcgctgc catactgatt tacaccgcta 30660
ccctatactg aagtctgttc atgccgtgtt gcatgatatt aatcctactc attgcgatgg 30720
aaatattgaa acaatggctg aaagaagtga gacgtcggca caaaaatcat cctcagataa 30780
ggctataaac tgcgaccgca gtgtatacat tcattcgtca tcacaaaaga aactcgaaaa 30840
gtatgaaagt gcgcgtagtt gttccaactg gcgcaaaccc gtgattataa atgatccaga 30900
gtttgatgat gaccaaaata tggatgaaaa ccggcgacct atagatattg tggctgaggt 30960
acgcgcggct ttggatatga tgcccgtgcc gcgtacccgt cacgaagtgt tggaggtaaa 31020
atttatacgt catgtaatgt ctttggtcac ccccagacaa tatggaccgc acttgaagct 31080
actcaagcgg attcaaataa cgcaggacga aaggaacgat gaaagtcttc tcgactttct 31140
atatagtgtc ttagctcaaa aagatgccga agaactatca cgtttaatac taaatcgcat 31200
tccaccccca caagattata gaactgtatt aataaagtat tgggactaag attaactgtt 31260
gtaagagttt ttatttaaac tattaataga ttggtaatca agagtttact gggaacagaa 31320
taacatattc gaatatataa gagtagaaaa ttaaggcgta tagagggtta cagatcattg 31380
agtacagaac cagcatatgt tgtattgcgc cgttcaaaga aattggtctg ctgactggtg 31440
gccataaacg ccagagggaa atcatgcttc ggtggcggct catcaaataa cggggccagg 31500
ccgatatcac taagaagcct atctgcgttg aagcgcacgt agctgcatat agcttcggtg 31560
tcgatgatag cactgtcgct aggtgctcgt gcgcgcagga attcacactc caatttcacg 31620
gcctcgctga atagtttgta aatgcggcat gtcgagggct tcttgtattt ctgtagatgt 31680
ttgttgtaaa taacacatga agcctttgta tgaatcgttt catcacggct tatcattgta 31740
ttggcctggc aggtgaccac aaaaatatta cgtgtgcgca tatacgctat ggctgcgaac 31800
gacgctgcaa aaaatagtcc ctcgattaag atcatcaata tatacttttc tggtatatct 31860
tcacattctt caacacgttc ggaaatccat ttcaccttgg atctgatcga ggtttcacga 31920
atagctttct tgacatattc tgctctggcc gttgcatcat ttttaaacag aattagttga 31980
ataatactgt atacgcgcga gtgaacagcc tctatcgact cttgttcaac ataatagtgc 32040
tgaatgtcct tttcttcaaa cagccccatc aggtttccga ggttacagtt gacaaggtca 32100
tcagcagcag aaaggaacgt gaaaatgaat cggtaaaaat caagttcgga tggtgtaagt 32160
ttatccacgt cggcagcatc atccaaaaac actaactctg actctagcca tctattaact 32220
atactaagag agcgcagttc attcatctct tggcactggg ttgtataaaa gtatgtttcg 32280
ggcggtccat aattaaggtc atcatcgtcg tccatcatta attgtcttga tggttcggta 32340
gcttgagatg cagaaccata gccggaatcc gggctcgggg gatattggtt tgcgttaagc 32400
acggggccaa tagcgtcatt ttgttgaagc tccatcttat gttctattgc tgcggtagga 32460
accgttgcaa atttagagag cgcagctcgt gcacacagac tctcctaagc cacaaaaaac 32520
gccgttgttt gtggctttgc gaacgcggca gtagtaagca gccgtcttaa ggccagtttt 32580
ataagcatga aggagtagct tgacaatgct ggaggcgtgg agtacgccct ctgacgtttc 32640
agtaatatat aatgaggttg attgactgtg gtcgacaaac ggcgccctat cgcgacacat 32700
gttgagtaga tctatctgat tatattcaaa aacagtctta tatttcataa ggctggcgca 32760
ctccggccga ttcccaaagg ctgcgacagt tgaccattgg gccgattcca aagcctccag 32820
agcctctacc ctatctttct catctgggta tatggcgcgg agctcttcca tcagtaaggg 32880
attggggcga agaatttcac ccgttgtcga aaccttattg aacagattgc taaacagtgg 32940
cgtaaatccc tcgctcactt cagttacctg agacgatgac accgttggca ttagggcgat 33000
aaattgagaa ttgtaaagac cactagtttt tacacgctcg cgcagctcat cccattcata 33060
ctgctcggtc agctccacat cttcccagcc atcgaaatga aaacgccccg atgagtatat 33120
gctttcatcg aaatcgctga attttggaag gccatgttca caaagctcgc aacttgttgt 33180
cattgcttcc agcagcatta attctgcgat gcgtttgttc agctcgcggg cttcatcgca 33240
taccatatca agcccaagac gcaaaaatgt tgtatgtagc ccctgaagtc ctataccgat 33300
cgaacggtga cgttccatac cagcgcgcga tttttcggtc gggtagtcat tgcataacat 33360
catcgcgttc acaaatattg tggcagttct gacggccctt ctgagcgtgg tacaatcaaa 33420
tcgtcccctt ccggcccgat caacgactat acatctcgat aaattaatgc tcatgagatt 33480
gcaaacgcca ttggaatctt tatctgcttt atgtactatc tcagtacaaa ggttagaaca 33540
gctaagtgca tcgaactgtg tatcgagatg gtaatggcga ttaaatgcat cttttagcac 33600
tataaacgga ctgccagtag tcgccgcact tcgtacaata ctatacatca tctccctaat 33660
tggtatgcta tcaacaccaa aaccgctgct ttcatagtat tcatattcac gttcaaagcg 33720
atcgccatat agtttagata agtttgatgc tctgtcgtca aaaaatgtcc acattacatc 33780
cttctcccca ttaaggtacc gttcatatcg tttgaacagc aaatccggta cccatagcgc 33840
actgaacaaa tgatcgcaac gcatagcttc ttctggggcc aataaacctt tcatggacaa 33900
aacggctctc gtgtcggcat gccatggttc aatatagaca caaacgccag taggtcgtgt 33960
gctatcagca ttaattgcca taacgagaga atcgatcatc tttaaaaccg ccatgagtcc 34020
ttttgatcgt gcgttctggt ttaatgtatg caatgctatt cccacaccgc cccttgactg 34080
taaaataggt gcaacctcat tcaaaattga gcgtactgta tcatcgtttg tcgtggtgcg 34140
ttgatcaatg agatagcagc tggctgtaga acctacagta cggcccatga acatcatcgg 34200
cggtgttgcg ggaacaacta attgtgaact aagactccaa aaaaaaactc cgaaggccga 34260
cttccatgtt gctctcccgc gcgttagtac tctaatcata tctggtgttt taaacgctac 34320
agttgccgca gctgccgcca atctggcgaa aaattgccct atagattctt tgcctcctcc 34380
ttcaaggtca gctaaataac tctcattgta ctttaatgcc gattgtagtc caatgtccat 34440
aaatgtttta aatgaacccg tgtaaaatcg tacgattgtc gtttcgacaa aatccaagtt 34500
tgcttctata gcaccacgta catcagtttt caatgccagc tccttcgaat aaagccaaca 34560
cttaaatggt acttccttag taaatatacg aagatgtatc agacgaccgc attctatgta 34620
caggcgttcg tcgaaacgcg tcttggattt tagtttgttg accaggaccg taatgtgctc 34680
cccaatacga tctagttttt ctctggtatc catcgattga tcatcataca aaccaaagta 34740
tgcatcgttt ggcagatgtc ccatctgatg taaccggtct tctattaccc ttaattggtg 34800
ctgtatgttt cttaaatgcc gcgcgcgcca ttcgccagta gatgttgcag agtcgacaat 34860
agattgatta aatgcgatgg atggccaata ggataaattc gccataatgt cgccgcgttc 34920
gtgtaccaac ttcccagccg cgtcgattat aaagatatgt gttgtgtaac cccctcggcg 34980
ggagcgcaat tgttcaaaga acagattgcg cgttctttac agactcattt gccttttatc 35040
tacaatgtag acgggcggct gtggcgtttc cccaataagg cgtggtttat tattgaaaag 35100
gagccagata cgacaagaag tagaaagtag ctttatcttt attaaaccgt tatattttat 35160
aattgtctgg cgcacatatt atagattaca aattgcccgt caatcagtaa tagcattcac 35220
gccacggcga accaagagtc caattgacac cttctagcca aataacagga acatcaatag 35280
atccataacg ttcagtgcgt tttaccgccc ttggagaatc gcccgtcatt attccgacgc 35340
ggcgataggc tgcatacata caactgtcaa tggtcggata gccacgtata tccggcaccc 35400
agttgaataa accgtcggtg gctctcggag caaacaatgt cgccctagga catcttggag 35460
cattgatatt ggaatagagc tgtaatagtg ggaatattgc attatctgta gccggagcac 35520
aaactgcacc ctgcattccg cgtatagtat tttctgttcg gagacggcca taaacatgac 35580
caagcccctc acgtatgcat atatcattca atgtactttt aatgaagtac gcgcgtacac 35640
cctcacggcc caaacgatga gtgtagacga acactaaata taaaaaacaa acaccgtcgc 35700
cagaaattct caattcttgg tcgagatcta gaaatgcaca ggctggaata tgcacggacg 35760
atctaggatt tgaagattta tccgtcttat aagactcctg tattccagat gatactgcag 35820
taacactggc tatttctcgc tgtgatatgt acgataataa tcctcctaat aaattaaaaa 35880
ccatatgcgg gtgtacgtga catctaacca tagctgttaa tgcttcccca aacctatcca 35940
aacgttggct aacgcgcctg cttccatatg ttgcaatgat atgcgctctc agggcctccg 36000
ctcccgagcg gtcggggtat tcttcagctc tagaagctac aagaaaggag aatgaaatca 36060
atgatgcccg aacaccattc tcacctgatc gttgtacgga aactgatgcc gtttccgaaa 36120
ggcgcaacca cgcctcttct aacactgtcg gattacgtcc ggggggtgtc gataggatag 36180
acatggaatg aatatcaagt ggatgacgga gtattaaaat tggcattcca ggacgctcgg 36240
attcagggac gcagaaatca gtcaaagaca cctgtctggc caggaaagta agactgcggc 36300
gcgtgtctaa caatggatca tattgtacca atgcgtgcat aatagtagcg gttacgctgt 36360
ctggtcctgc cgctggttgt aagaatgcag tatctgttgt cgattctttc agggtgttca 36420
acatccattc tagaccggat ttcataccag ggttagatcg ccaatttgca tttgatcgca 36480
ttccattcct acgcccgtcg atcgttattc ccgttgctat cttccgcaac gggtcatttg 36540
acgtaacgga gtaaacactc cggtggccag aaaattctcc atttccattt ggtactttca 36600
tcgccgggga gtagctggaa gctgtacctt ttccgcgctc acttattaca ctgcatatag 36660
tgttgacccg tgttccgatg agaggaatct ccctttatgc gcaacgacca acaagtgaca 36720
aactgccttc gggtcacttg tgtgaataga acagatgcga aatgtacgtg gactttaact 36780
tatctaataa ggccaaatag caattaaaca ccctgaatat gtatggtcac gtagttttct 36840
tgcggcagat cgccgcgtag acgcttaaag atgcgatcca cgttatcgaa gttaaagtac 36900
gatagtttct cgccacatcc ttggtgaaat aaggcaacac atatgacgtg aaattcaatt 36960
acaaagacac gtcacttcga aaacaatggg cgtggttaca gaatacccta aaacaacttt 37020
tcaaatgcct aaactctttc atcttatact atagcagacg agcgcacatc ttttggctcc 37080
aatactgtcg ggtcaactac ataggtagtt atggattctg gcgaccagct atcagataat 37140
gaatattacg acctcgatga ggacaataca tgtagcgaca atagatcgcc tagacctgta 37200
ggtagatggc ttcttaaaga tatgatagta gcactaaagg aaataattaa tacacaatca 37260
acgccaaggt ggaccgaagt tgaagcgtca aaagtaaagg ccatcgtgag tactttttgt 37320
ctttcgcaag aacaaatgac tataccgcaa atttcgcatt catggaaaga ggcattcgac 37380
ctgctgctcg tggccttctc caatacacaa acaccagaag ttgctattat tatagagaat 37440
tttacaggtt tggtaatatg gcgactcgtg gtatcgtggg acagaaatac cgtcaaagcg 37500
gacgttacaa aacttatggc acttgtacga gatctgacat ccgaacacgt cacacagagt 37560
ctgacacgac aaaatttaag attatcaact agctatggcg tgtctgcgat gcgcggcaaa 37620
cttttatcct ggttaacaac cttcgaggct gcagttacaa cagttttggc aacaacgcct 37680
gatgttttac tcgactcaga aacgtctatg gattccgaaa agatcgtgaa ccctttacta 37740
gccgatacat acgcattaat atatgatttt ccgttcgtac aagaagggtt acgctttcta 37800
cataggaatg caaattggat gattccgttt aaaataatga cccgctgtgc ttcggatacc 37860
atatacagtc cattagtgcg cacaatttat actatatcat tagtggatca gtatttttgg 37920
ggggccgggc gttctaggcc taagaggctg gtcgatcaat tcgtaaaaga tacggatcta 37980
ttaggagatg ctgaattaat gtctccgggt gaggcaaact caacaaaacg aacatcatgg 38040
gaagttcgtc tatctgctgc tttagcttat caggacccat ttgtacgaga agtacaacca 38100
ggaatggcgt ctgtgcgcgt tcgtacatca cccgatatgg tattgcgcgg aggtccagta 38160
tttgggccag cgctctgcat acactcggca gctgttttaa atgtcatttc tgggtctaag 38220
caagatgagt ttgatttagg cagactgaat caagctgcaa aaactacaat tactgaagca 38280
gcaagggcag catgggatac aatacaacat agcaatacgc ctcaacaagt aattgatgca 38340
ctaatttcta cgggttttgt agcacaaaat tgccgtaatt atgaggtggc attaacctca 38400
atgtactcgc gagctactac cgataatgga tatgcgctaa atgataccca acaggtgata 38460
ggttgtgtct ctatggtcgg aaatgttgtg tttggtctca tagatagcta cgggcgcgat 38520
gccgactata ttgatgcata tgcagaggcg atgtcatcgc tcgagtctga cagcggcgat 38580
tttctttcgg ccattggtct accgaaaggt ggaattgaac aaacgatccg ccattgtatg 38640
gcaccgcggc caataacaga ctatatacgt gccgcacgcc aagcgctagt acaagaaata 38700
gaaactgcgt ctagtatata taaaggacgg ctttcttcga gactgcaaac acatcatact 38760
tcgacccaca acagcgtccg tggttcgtta ttgttgtggt ttgattttag agccaagcaa 38820
atttggggca tcgagccacc ggggaacgat gaacaatgta ctcctgaagg tcatgcggtg 38880
ccgagaagac gtcagacagc tgagaatgta acacctgttg tagcctctag aaatgcgtcc 38940
gaactaatga atgtagctgc aactatacaa ttccctagcg tcgctcccca agggactata 39000
atcgactcgg aagcattcgc accttatgtt gtagcaaccg ctggggcaga ggcgctctct 39060
acattagcat cggccctatt ttctgtatac catctagaga ctgcgatacg tgtattacta 39120
tgggcacgag aatatggtat agctacaata ccaaattatg acgggtttcg gaccaaaatt 39180
acagcattat tggcggcaat tgtgcccttt acgagccgtg accctccaag gccaagaacg 39240
cgcgatgctg agaatataga acgactgtta aacgaattgc agtcgtcagt aagtgctgct 39300
atagaagccc ttccagatga ttcaaggtta acaataccac ctaaaccaga tatatcaaac 39360
agtgcgcttc ttattagtat gcatgctaca gcattgcgta tttcagtaga tgatcttcga 39420
gagcgtacta tacatttaat agacgattta ctcatagcca tagactctct agcatctact 39480
acatcggctc tgcgactatt tttactttgc agattacgat caaatggcaa tggactaatt 39540
gttactatta gtgggcgggc tggcaatcgg acgacaaaat ttggttcatg gcgcctatct 39600
gatatagttt ctgctataga caccgcgtat ggatcatgcg ttgaactatt agcagatatt 39660
cgtatgaagt cgatggcgtt acgtaatgtt ttgtcggata ctaatgccaa gattcctatt 39720
tgtgatgcac tagccgcacg tattggcaat aactcttata aacgtatatt tagcacaatt 39780
gcatcagatc tggataagct atcaaatgtt caaacggcac ttgatctgcg gatacgaaaa 39840
ataacgtcag gttccgagcc cccaagtttg cgtccagttg ctcagtttct gagacgttgg 39900
acggagattt ataatgctta tcggtcggct cttgttaaaa aaacggatga aacatttact 39960
acattggcag aaacgctacg tattatatgg gacttgatac agaacgatcg tgccggggtg 40020
ccaaagggat gttcatatcc aacggacgat gacttggaac atgcggtact cggtttaatg 40080
acagaataca cacaaattaa tgatctagat gaaccatcga cacctctaac ggacaggcgc 40140
aatgtatctg acgaagaaaa tataaactat gcgccattgg aaatgcatac gcataaacca 40200
ccggaagttg atccggataa tcatttagat tactttttaa attctaagag gctgacacag 40260
gatgatttat tgtctatagt agacaaaatc ttcaacgctg aacatgtata actttacacg 40320
gccctcgaag tgtttacccc ctcgcttttg tttattaaaa caacaatatc cgtttatagc 40380
accatactgt tgatttacaa tcctaataaa agtgttattt gtttggggta tgatgaagac 40440
ttttccatta tacagtgcga cggtcgtcga tattactaga actgctcgga catgatatta 40500
gtgtaaaagg cgaaagtgct cagactgtta ccaaactcat tctaacggag acccttatag 40560
gggtttatag gccgtcgcct aacaaatgca tcttggtcgt taacggggat ataaaggggc 40620
gtgagcaacg tatatgcacg ttcaactgcc ccgtcggaca gatgcaacat aggatagcca 40680
gagagataga gctcgctaat taatcgtatc ggagaggtga ctaactacaa tggccgaaca 40740
gacgtctact aacgaacact cttcacactt ttgcctattg gggattggta cagaacaggt 40800
gatggcgata ttaggcgccg aacgcagttc tggcacgtgc acaaaagata tggaatatga 40860
tctcctggca gccgtctcgg aagagtatag gggtaataat tggagtagtc aattccatgt 40920
ttggaacacg ttatcggcag tttcgttggt gcattctatt ccggcggata ttaggtttga 40980
tggaagtgtg ggttccgaaa agccgtccgc gtcgccgcca tccctgacag ccgaccaaga 41040
tagcacgtct gggtctggcg gctccaggga cgacccggta ggtttcatca tcgccacggg 41100
tacaacgaac caatcttcat acgacctcgc cccttggggc gagaaggccg gcgcgctaca 41160
taccttggcg tttatgcgcg cgtcgttcct gtcaggagtc tgtgattact catctgatgt 41220
aattaatgca attctacgcc aaggtgctag ctttgctgaa cagttgaaca agcagcccaa 41280
aacatttgta catccaaatg aacttccgta tatcgttcgc ggggcagatg gagatgcact 41340
attttgtttt gtatccggaa cattcataat cacgactaca aaaacgccgc caaatcttga 41400
ggaaagatta ccatatgtac cagaaacccg tctgatcgaa gggattccgt ctatactaac 41460
aatttggtcc cgatgccacc agaaggcaga tggcttatat gtaaccgtcg gtaacacagt 41520
gttgggaatg tggcgcgatc cttccaaaga atgggtaaca gtttttacat acagtggatt 41580
gaaaaccacg acagatccag cgtctatatt tcgtgttcgt ctcaaacacc tagagggtat 41640
gttaatgtgt tataccattg gtatgcatat gctggccgtg aattttgcat attttctcag 41700
atctggcgat tcttctttgt ctgtgtatga aggggctacg gctgcggcca atttttatgg 41760
tacgactgat tttactctat gtaggaactt tagtggatca caagaacaaa ttacagtgtt 41820
agtacaagcc gaagctgtct ctgtagctgt cgcatctgta aggtctgggc caacagcaag 41880
ggatctgttg aacgtcatct ccgcagccga cacagtagcg caaactaaca gggatcaacc 41940
aattgtaata gtaagcaaat ccgtgtcagc ccacgccacc gttacggccg tgggttatag 42000
aaaccaatat gcagcagaat tgtgcccggg ttcatcggtc tcgtgtttgc gctcgtcgct 42060
ggcatttctt agagccctat atatttttgg aatcgaatcg tcatattctg ccgacttggt 42120
tgacgtattt ttgcgacaag gtcgagagtg gaccattgat actaccgcgc ggggcgaaca 42180
gccaagtatg tgctcactaa atgaacttcc gggccgcata gaatcatcag cgccaggtat 42240
tgtggattta tgtgttgtca cgtcacgtat atatggtgat tacccgtttt atggtggacc 42300
tggaatagaa aaggtaatgg aaacaactat ttccgcgcgc gtatttatag acacggtcat 42360
gacacaacgc aaagagacct actgtttact tataattgga gcacagggtt ttggattgta 42420
tcgtaaagat gactacgtgt ttatattcga tccccatggt catgctgata tatctcaggc 42480
ttttacggcc aggctatcaa tcggtaacct atatccattt ttaactacat acgctgatat 42540
ttccgccaat ccatattggt ccggcgtgtt agtgtacttt attgttaccg gtccggggac 42600
acctactact gatgagttga catgtgccgt ttccagacta tatggaactg gggatacaca 42660
atttttagag agcagcaagt attctaccca aaaagttgtg gcacgactgg acggtcttat 42720
tggactgaac gcaaaaacaa cacatactat aggcgtcggt ggatatgcac acgccccatg 42780
cgttacattt gaaactagtc aggggtggcc aatagatata ggtaataatg tatatgaatg 42840
cggcgacgcc ggtaagttaa aaaataatgc aaaggaagat aatgccaaat ctgaacatga 42900
ccacgaatct atgttaagtg atagtgtggc agtaaatgat ctttcatggg aagaacaaag 42960
atgtccgtgg aaaactgcct tcgaggaaac ggaaaattgt tcccaatcta cggaggaccg 43020
tgtaaacgaa ttaaatgaga tatcaacatt gtctccagtt gaagaggcta tttcaacaag 43080
cgatatgata tataatgcta ctggccaaat tacttcaccg gacttcgaac cagtaccacc 43140
accatcggca cgcattcgtt cgaagcgcag aaggcctgta tggacaccgc catcgagtac 43200
agagaacctt acaggcggat tggcacaaga ccgccattca cgtgttaaat atacaaagcg 43260
cggaaggcat aagagacggt ctcaagatac ctctagcagt gcgagcttat cgggcagttg 43320
tacagaactg agcgatatga tagcggatat tgcatatgca cccggtccta ttgccatgtc 43380
ttgcgagtcg caaaacaatt caattcattg tcatcagtcg ggcaatattg caccagataa 43440
tataacagat gaaagtaggc aagatgaaaa ctattctgtt gagatgtggt ggaatgatga 43500
atatttgaat gcaattgatg tgacagatat gacagataaa ataatggaaa ttgatacgat 43560
aatagaatcg gatatgtcat cgccagtaag ggtagtccgg ccattaggaa gcaataacga 43620
agatgattta ttggaacaat acatcctcac aatttattcg cgcatgtatg cctttattat 43680
agaaaatggt gcacggactg ttccagaacg tcaatcatta attgcgccgc tgatacctgt 43740
catctcggca tcgttcccac gaaaaactgc ctttggggct tttatagaat ccacaggtat 43800
gatactcctc aacgtcccga tacacgccga acttatatca tcagtcagaa cagaaggtgc 43860
tcatctagga ggactggcat taattaaaat ggtattaatg gcgatagatt cagctgtcgc 43920
ttctgatgaa ctacatacac gtttagatgt tttgagagaa aatgctcaga agactggcac 43980
cggtggctat gaactagtgg cgtcggcatt atcagaagaa tttacaaaaa acacaattgg 44040
tatttatgcc gagaagacat acacacatcc ttcagtttca ctgtcggatc gtttaaaagc 44100
tatatgcgaa agcattaggg ttaatgaact ggaagcaaag aaaaccggtt tagagttagc 44160
aaaaattcta gctgctatcg gaaccggcgt caggcgaatg catgattatt atgacacatt 44220
ttatatcgac gaagatcccc tatcggctcc catgataagc gaaacattat ctccaattag 44280
agctgatgat gtacccgcaa agatctccga gatttatgag gaggccgtag gtgtactcgg 44340
aaatgctata cgggaatact gtctcaacgg agcatcatac agcgccaagg cactatcggc 44400
cgaccgcaat ggtcgtacgc gatttaaaat agccagcgtt gcaattgatc ctattacgcg 44460
tatggtgaac tctctaccag catttgatag cgcattaaca atgctggctt cgcgcgccgg 44520
agtggattct ccgcaatcaa tatcatccag tagagaagcg ggactactat cagatctatt 44580
aaatgcagga caagatattt ccaatgacga aacactagga aattggttag ctctcatgac 44640
tgaagcgcag atcaatggtt atatagaatg taaagagctt gccgcattaa tacgtgaaat 44700
aaataccata aacgaacgag ccgcgcgcca tgcatctata gaagcggaac ttcaaagatt 44760
cgaggcactt tcggcagctg ttcaagaagc gttgaatggt gcagctaggg gcggaccggc 44820
cgcagtgtca ttagacacgc ttatacgcgg cgcggaggaa ctagtcgccc gtgctcatta 44880
tattgaatct ccacgcattt catgcgattt gactgatgaa cagcgctcag ctgtaagaga 44940
tcgtcgcata gaggtagaat ctatgttaca cacatatcgc gggaaaatgg acaagattag 45000
cggtgtactt agtagcctgt atgaaagttt acgtatgata tttaaaccta ctaacaactt 45060
cattggtctt agaaacatca atcaaaatgt aaaagcctta acagactctc tgcccccaga 45120
actcggatcg ctatctgccg tagtggccaa tgcaccgcaa gatgtttcga gggcaatgcg 45180
tacagactta tggacacatt tttcgcatta ccgcgaggct ttagaaaaac caactacatt 45240
tttagctacc gaattgtcgg gcctgggtcc ttgttttaca ttggccatta aaataactac 45300
tgaacatatc ggcggtttcc ccggggcatc tgttttcttt ggaaaacatg cagacggcgt 45360
tgctgctgcc ataacggcgg cggtcgccag ccctaaatct gcaaccgcta caacagcagc 45420
cataaatgtt ctggaagttg ccatcgggga ggtggatcat gtggtaacaa aaatgaagga 45480
caacacagcc aagaatgcca tgtcatttct gagaccaata gtagacaaat taaaaacaca 45540
tcttatcgca atcgatgaac ttggtcatgt cgaagcagca tcccgtgcct tgcgctcggc 45600
atctgaaaca tctgccgcgt tagcttcaaa aatacgggcg tccgatccaa gcataatgga 45660
tgatacatca tttgcagcaa tggccgcaga agcaaagcgg gtttgtaacg aaacgaaggc 45720
agttgccgat agtgttgaac gtgacttggc aaagacgcca ataaccatcg ccgcgtcggt 45780
atttaatgtt aaagaggcag acatattaaa atatatacag gcagctaggc aacgagttgc 45840
ggaagttgat tcggcaatga gcgatgcctc aaagactcat cagacagtta attcggagcg 45900
ggcattggca atttggaaag actcagtaac ggcagctata gttagggccg agacacgctc 45960
ggaatttgat cagcaagagc tcacgcggtt aagcgacatt gctgcggtcg atggatacaa 46020
gacaacctgg attaaaaaac gcgccgaggc cgtagcagcc aatcatttat cattggtaac 46080
gacagccttg gatacggttc tacactttaa cccatatagc acagagaata tgcgcacaaa 46140
ggcaccgccg ccaatatctc tgctgcgcga tattacatgg ggagatgctt ttatggctgc 46200
cgcgccagct ttctccgaac tgttcgaagt tgacgtagag ttattgataa gtgcattacg 46260
gatgaccatg actgttttag cacatattag tgccagtgcc ggatcggtag atttttatga 46320
tttaattggg catatagaac gtgatttaac gcgccatgcg ccacttttaa aatatataca 46380
gttttacagg aaggggaata ctaagttcaa ggaaatagta ccaatattgg atgctatgag 46440
ggccgacgtt tgtcaagcta tgggccaaat accctcggag ctcaatcgcg ttctggagga 46500
catttcgcgt atacgctgcg taaacacagc aagaaatata ttagaaaaca gtgtacgttt 46560
agagataccg agtatggcta ttatagaacg gatagcatcg gaattagaaa atctagacac 46620
gcaaccgctt aaggataccg cttacattga atatgtagaa aacgcccgca aacactatct 46680
ttccgaagca aagtctgcaa tggatacagc ctttaatatg tatcgtgatg ctgaaacaaa 46740
ggcgaaaaca ttactcaata atataataga aaacgataag gccttggaaa aggataaaat 46800
agagggatta tctaacctta aaaacttact aagactaact ccactagctc ctcattatat 46860
gaaagctatc gataaggcag aaacggcaga tgatattgta acacaagctg cactaatatt 46920
ggcgcatgta gagaaaacag aagaactaga tgttcaggcc gtcgagtggt tacaacaagc 46980
taaggcaatc atagactctc atccccttac agtgttaatt gatgatagcg gtccaatggc 47040
accttatgcc gaccgtatag acgcgcttgt gaccttgaga agtcatctgg acgaactgac 47100
aaataatatt gccagttccg aagcggcatg ggatgccgcc tgggataatt atattcgaga 47160
taaaaacaaa gtcgatgtag atgcggacgg atatgctttg gcaatgaaca gggccaatac 47220
tctccaggcc gctggaagtg tagtattggc attgcgcgca gattcggagt atcgtcgcct 47280
tccgaccaaa ctaacctcgg cattagatac gaaatatacg gaacggctgg ccaatttaga 47340
cgcatttacc acacggactc gtgatataga tgatgcctct cggcatcttt cgtcgttgtt 47400
aacgaaggtt ccgaatacat atgatgtgcg atcattgcgc caccaaatgg cccagctagc 47460
ggaactactt tctaaattac ccaaatggtg tgccgaagac gcttctccat ttaagcacct 47520
actacaacta cgtttaactc tatacgctgc ctatgcagat ttgtgtgccg gaagggctgg 47580
cgtttccgat ccaatactcc atcaaagtcc cataagaaaa caaaagaaaa ttgacgccgg 47640
tgggggtata gatagactat tgaaatgtcg tgtggcggcg aggctcgaat cgcgtgttat 47700
tatgacagtt agagaatata catctgatat agatccaata cacataacat atatggatac 47760
caccgacgat cctatacact attccatgtg ttatagagca gcatgtgaca agattgccgt 47820
taacatgttt ggagatggga ctgccctact tcctcctatg ccacgtattt ctttatccga 47880
cggcgcttca atagaagctg cgagtatact gcgcgagtta ttggatatgc gtgttcagta 47940
ttacaaagcc attggctctg attattccac attcgcgaga tttgtacggc ataagagacc 48000
agattggcgt ccggaagagg ctaaccgtgc agtcgccgaa acttattcag cgttgatagc 48060
cacgacacta tgtagacatt tagggggcgt tagctgggga gagatatcat ttgtagaagg 48120
agcaactgga ccggtagcat gtccatgtac acttatacaa gaaccccctt acagtataat 48180
aggaaccaaa gatgcaaaac gtagcgcacc agtttctctt gatcttggag atgttatggt 48240
cactcttata gcatgggccc cgcaacatgt attaacgttt gtaacgctcg acctagttct 48300
tcagcatgaa tatatgtcaa agacgttacc tacagccgtt gcgactgcgt tctctagtag 48360
attgctcatc aattctttgg atctatcgtc cagtaatgat gaacacacgc gtgtactacc 48420
cggttgcgga aaccgatgtg acccttcaaa tggcagctta ttcgcgcttc gaatgattga 48480
ttggcgacgc ggacgcttat cagaagacga tccattaaag ccatgggacg aaaacagcag 48540
ttatgcaaat tcccaaacta tgataactga cattgcaaat ctacgaaatt ccataccgtc 48600
ccgtatattg acaaccatga ccgttttggg tcgcatgtgt attccaccgg cggcgctagc 48660
agcgatgtgg tcagtgttgc gtccagaaga tattgggtct gagatatcca cgtatgatat 48720
gttactgcgt gcccgttttg acacatcatc tatgattgga acgtcaatat ctatagaagg 48780
acattgcaat aatgtggatg gttcaacaac gaaacggacc aatgtttcag gaaaacctaa 48840
atctctgtat gagccaactg gtacaacagt ttcatttact gtaattaatg caccaccgag 48900
taatgttagt cgcgttaatg ccatggatat ggccgttaca gcaactctcc ttggcgctaa 48960
agtagttata gcggcagagt atccaggtgc ctactcggac ggctctggcc taaccctatg 49020
catgcgtttg tttgactctc gtgataattc agaaggttct tttataaata cttcttcagt 49080
gtcaacggac ctatcgtcat ggggtataaa attattggat cttgatccaa atagtataga 49140
aaactcctgt ctaatagcac aacttgaaaa cctatctggt atcatagcat caaaacccct 49200
agaacaagcc gacccgtgtc taattctggt cgatggccaa atgcgcccta cgcaggtatt 49260
atggcccaag gaggctgtta aaataccaat tatacgttta gtatctgaaa aggcagatgt 49320
gttggacgaa ctgccgtata tcgacacaga agaagaaact ctaccgcaga catcggacga 49380
tccactaatg gtcaatattt taggttcggc tgatgcgtcg ttttcaaaac ctgaacaacg 49440
ttatccaatg ccccgttatc tttcatctac acggcataac ccatacgata gtgaagatta 49500
tgactcatct ttatctgagg acgccgaaga tgcaaaaaca attgacgggc cgtctatctt 49560
cgaagactat aatgaagacg acctattcac ctgcgccgcc tacgcgaatg ataacaacga 49620
gcaggacgtc gcagatgaca tgtcgacccc atgggcgaaa tttctagtag atgatgcaac 49680
aaatgtcggt tgtgatgtta acagaagcgg ggctgctagt tcgcctccga gccgtattgg 49740
tgaacgcatt caagagcaaa ataatggaca aactggttct gatgagaaca gaaataatag 49800
cgtagctaat gcatgcgcaa ctgacgagaa gcacgcgcat agtcctgcgc gaccttctgc 49860
cggattgaag gaatgcacta gcattacaag tggacggtct accaatgaga aacagatgag 49920
acggaaggcg caccacgtac gcgatcggga attcaacggc agagatgtat ccgatgacaa 49980
tactatacaa cctgtctcac attctccaac agacagtaga ccggcagggc caatcgagcc 50040
gacagccgat atacctccaa cagacagtag accggcgggg ccaatcgagc cgacagccga 50100
tatacctcca acagacagta gaccggcagg gccaatcgag ccgacagccg atatacctcc 50160
gcaatccgcg gcagcatcga cggaatcgtt gacttctcgg gcaaatgcgc cgtcatcgca 50220
aacatgttgt gatactaatg ggccacgagg atctgtcgtg aatactaacg ctaaaaaagg 50280
tataccgcgt gatacaagcg tcaattcagc ggcctccgta aacgttaata agtctgttac 50340
gcctaaaggt cgcgaaagct acaataaggg cgttgggttt gggccatcgg taacgccaaa 50400
cgcggccgga gaacggcata cgcgcagcag tttgggcaaa caatcgcatg tacctgtcgc 50460
ctctgcagat aaagagccat cccatagtac gctgagtaca atacagaata gtgttgatga 50520
taggccgaaa cagttaaaac ccggttcccc caaaagtcag gaaacgtcta gacatgctgg 50580
acgtgaaaac actggaaact gtaataaatc cagcgcagat gttttttcaa catcagaatt 50640
cgtgtgcgac ggtggtgttg atgtgtcaaa actgcgttgc aaagttggaa aacaagagtt 50700
gtgccgccgt cgactcaccg acactctgac cgaaagacga gacggccaga atggtggtgt 50760
gtcaaaggcg acactcaagt cttgggcgtc aaaatctaac ttacctatgg cagcgtcaac 50820
atatctctat cgtccaaata ccacaattcc agcggatgtg ccaagtgcgg cgcatgacac 50880
aagacataag gcagacctaa catgcggcaa tggattgccg acagcacctc agtataaaat 50940
tgtaacgagt aataagcaac cagggggcgt cagtgtccaa ccgcccgata cttcccctgc 51000
tcagatacat caatccgata cgtcgcatac caaactagta accgatggtg ggcataaaag 51060
cggaggactc gaagcaggtg ttttaacgca gagccgtaaa atgcccaaat ctggtatata 51120
taaagcaccg ccaccgtcgg tgcataggaa caaaactgaa actactccca aatatgttaa 51180
aacggccaga tattcttcct ttgatccatc tttagaccaa gaccattcat ctgcatcgga 51240
atcggattac gatgagaacg atgaagagat aagtttgtcg agctatgaaa gcgacatgga 51300
ttcgccggaa caatcacata ctgatacaac acaattaact cctagtaaaa acggaagggt 51360
aattcccacg gaccacttgc tcacgcgccg agaattccgg cgggcaggga gaagtgtcct 51420
atattcactt ctacaagcat gtagacagat aacacgttct ctatctgacg ttcgcacatc 51480
aataatagct agaagtagag aaataacgct cgaaatactt aaattaaaat taatattagg 51540
ctgacgcaaa tataacatac tcaataaaag cttttatgaa tctttattga atcatactca 51600
tttattttat cgctgatcgt ctggcgcgtc gcgtatgatg cgtggagaaa aggtgcgctt 51660
gaggccaaaa ctcggtcgta cccacgatgc tccatctgtt ctgccaaaca tggggtatct 51720
gctgagagta gcgtcatcat tcgctctgcg tatggtagta agtccagccg acaacgccct 51780
gattaaagcc aacctcgccg ccgaaactgt gttttgccta acattagcat gcccacttac 51840
tgaatttagt tccattagca acgcaaagaa cggtactgcc gatagtgcct catatgtgta 51900
ggtctctggc cttctaggat caaatgtagc ctgacaagat gaacctccag aattagacat 51960
tgttgttatg ccgtagacgt ggtgttgtat gaagagcgtt ctctatactt aaatcgtccc 52020
tatgtagagc ctacgccaga aatgaaaata ggaactagat acggccacca aaaggccaaa 52080
tgactaacgc aaacatgaca atcagtatac atagtgttag caccgcccac atagaaaatg 52140
acgtattacc ccgcaataga ctaatgatct tccagtttcg tagagaatgg aacaaaccat 52200
ttttttcgtt actgtttggg tccaaatctt ctaaaggagt cttcttaaga tccggttcgg 52260
tgcgaggttt aggtatgcgt ccagtagcat cagagtactg tttttttgct tccatcattt 52320
ctgacatcct tagaatacgc gcggctcttg atggatcttc ggggcccata aatctgaacg 52380
ataactgtac acaaggcata cgtacaaaac acactaacca catgcatgat tgaagcgggc 52440
gcgcgtcgat tccagccatt gttttcattt tctctatagc agatagactt atgccggccg 52500
attctgtaga cttcaatatt atattattac gatctacagt aatcgccgta cttctgcagt 52560
cctgcggtcg gttgaaatat ccttgtacaa gtacagacac ccccgtattc agtattttca 52620
caaatggatc acatggtatg tctctggccc agtctgccaa catgcgcatt acatactcca 52680
gagggaacgt accatcactg ccatcctgac cgttaaattg atagacacat cgcgttggga 52740
gtctgtcgcc acaagacgat aaaattgctt ccccatcgca aggttgtagg cccccagcag 52800
caaccaactt aattcgctgt attaggtccc taccaccata accgcgtctt ctgaaaccgt 52860
ctggacatgg gtaaagctgt tccatagccg ccgtaatata ctattgtata tggtatcact 52920
tatcgtccaa cgtattagta cacgataatt gatcaagtaa cacattgccg ccttttatag 52980
cattccacta tgacgtgtca tacttccacg atcgaactga caaatcctaa ccaaagcacc 53040
tcccattatg aatatgccgc cgataagcaa catacattta tatggcagca taactaacta 53100
tcgcgcaata tctgatgtag atcgagcaag cgatttatta ccgctgcaaa tctctccctt 53160
ttgtcatgaa gtgccttatc atggcagcat gataccgctt tggcgtcttc tgcatgctca 53220
ttgtcaactt cttttcccat tttgttgtag ccatccacac gtatgtgtgc atgcgccaaa 53280
actgatgcaa gcctcctagt aaaggacaaa taattgagct tacagtcagt agtgggaaat 53340
atagcctcaa actccacagg tacgagctct tcaaaccaaa tatcgtaagc aaaatcatca 53400
ccgataatat acttgtcaac tagctcagac agcgttaaac catctaggtc ttcattgggt 53460
atggcatcgc ggagtctaca cgtcgattct acacggtcca tggcaagatt tgcagaagag 53520
gtaccgtcga cagatggcga gggttggaca agtggtgcgc ttgacgctga ctactgtgcg 53580
tttgatcctt cactacttgc cactaatgag cgtttgtgtg atgaattaat gtttgctgcg 53640
catcttatgt cagtccctaa tgaaaccgct actgaggtac gtgatgaaaa cagggatgac 53700
attaaccctg cgagtgataa tctattggtt cccgatttgg cggcgtttgt cgaggcttcc 53760
gctgatgcat ttgcattaga tcgttcatgc ttagtgtgta ggttaataga tacgtataag 53820
aaaaaattcg gtctaacgtc ccaatggatc gctgattatg caatgttatg caacaagtgc 53880
ttagctgcgc ccccttgcgc gacaactaca tttatcgcag cgtttgaatt agtgtacatc 53940
atggataaac atttccttgc gacgcatcgt accacactta ctggatcgtt tgcacgacgc 54000
gtactcacat taaatgatgt tcagaggcat ttttttcttc atggttgttg tagaacagat 54060
ggtggtatac ccggttctac atcttcaatg aatcaaccgt tagaatctac aaatacgcgg 54120
attacttcgc caatggtaca ggcaagaaca tctaggtcta ccaaagtgtt attcagcaac 54180
tactcctttt tggcccagac agccacccgt acgatgttaa tgacattggc cgacaattct 54240
tcaaacgacg ttcagaacaa tggtacgcaa cgtacaaatt actatagttc tggtcatcat 54300
agcacgctaa cagctttgcc aggccagcca tcgttagctg cggcattggc aggttggaag 54360
gaatgtgcta agcatgtaga gtgccacggt tctgctgctt ctaggagtgg tgtcggtcaa 54420
aaagatagtt gcgctacctt ggcgtatgtt gacgatgacg catttgaaat gcatgaagaa 54480
ctgcgcttgg aaagggaacg cgagcgagca aaatctcact ctatgtatgc acgtcctaaa 54540
agattggcga ctaggtcaaa acctgcgcga gacgaaaatg gggcaacacg tgtacatgga 54600
accggaccat cggaacaagc ccaccgagag gactgggcgt atgcagattt gacattgctt 54660
ctactagtcg gaacaggggc tatttgggaa ttaaacgaca cgaccaatac cgtattactc 54720
gcaagacgta atgcggtggc gcgttactgg cgagaccata aacgtgcact ggcgcgagaa 54780
accgccccca aattctctag atttgcagaa aacgatgcag agccagtgac ttctctcggg 54840
ccagtactcg caactacact aaaacataca agatgcaaat ctcgtactgg cggggaatgt 54900
atattatgca acctattacc aatacgtacg tattggttgg cgattcgccg ccttaaacgt 54960
gatatagttg cacattccgc gaacaactta ggtctatttg attgcatagc accagttata 55020
gacacttggt ctgaaggcga atacgaagaa atcgccgacg gcggtaggtt tgtagccatg 55080
gtaaaagctg ccggcgcaga agcagtttat aaacatcttt tttgcgatcc aatgtgcgct 55140
ctttgcgaat tgcagaccaa tccgcgtgta ttatttgacc atccaaccaa atcggatcca 55200
gatgctctga acctatataa ggcgcatttg gcgagcgaaa accgttttga ggggcggata 55260
tgcgcaggtt tatgggccct ggcttatact tttaagactt atcagatatt cccgcccaag 55320
cccaccgcat tggcctcgtt tataagggat gctggtctcc tattaaggaa gcattcaatt 55380
tcgctcgtct cattagagca cacactcggc acctatgtct gactacgata ccacaactat 55440
gcactcgtct gctaggcgca gacgttctag ttcgttcgga cccatgagag ccagatcttc 55500
tggatcgaac gtaccgtact ggcgaccgta tagcaggaga cgatcgatgc ttcgcccgtc 55560
aagtcagcgc ggcgaaacgg ttgaacgata cagacggttt tttgaaatga tttctagatc 55620
cccttcagat gagttagcca tagtacggga gctaaacgta ccgcttatta aatcaactac 55680
tgttgtactg ccgtttgacc tggacatggc cgtcgcagac aattgcctat ctctatctgg 55740
catggggtat caactcggta tcgggggttg ctgcccagta tgttcatcgt cgggggaacc 55800
tcgtttgaat cgcatagatc gctcaacttt gatccttgca tatgtgcaac aggtaaacca 55860
cctataccag taccgtacat tcctcgcatc gatacaagca gcatccgacc gcatttctga 55920
tgatgcatca gaaacggaaa atatactggc ttgcattagt caacagccag aattcttttt 55980
cgcgtattac gttttacgtg aggctggtat gcgtgacata cgtgtattat tttaccgcga 56040
tgtagacgaa ggcgggtatg taatgtacat tccatttact ggaaatgccg tacatctaca 56100
ctatcgtctc atcgactgcc ttaaatctgc ttgccgggga taccgtctaa tggctcatgt 56160
ttggcattct acattcgtac ttgtcgtgag gcgcgaccgc gaacggcaaa ctgacgtgga 56220
cagcgtacca cagataagta ttgaagatat ttattgtaaa atgtgcgacc ttaatttcga 56280
tggggaactt ctgctagaat atcgaaagct ctacgcagct tttgacgatt ttcctcctcc 56340
tcgctgagtg gcatccctgg gtacaagcgc acttctgcaa acccggccga agatagcagt 56400
gctgcggttt cgtcactctc acagtatgtt tctggaataa agcgttttaa aacagcttcc 56460
gaagttttgt gatcattacc gaatagagcc ttgaaagtta cacttagagt ccccaacaga 56520
tgcgaaaagt agtagtcggt gttaagcggt atatgattag ctaaaacata gcccgggtcc 56580
tctgccaact cagaaaccaa tagcttgcgc ctcttcgccg caggcccatc agctttgcca 56640
gtggaattac ttggccgttt gtcgccgcgc atagtagcaa cacgttcggc atcgcgttct 56700
acgcttggga tttgtgccac aattacataa ggaattcgtt cttttatcgc aggaggctgc 56760
tcttcgcgca tacataattt gtagtagacg gtcagatgcg gtatgcgctt gttgacatat 56820
gcttctggcg cgcggcttag ctcggcagtc atgacaaaat ctggtacatt tagttcacgt 56880
gcacgaattt tactatatgc ttcagctaga gtagcgccaa attcacccaa accagggggc 56940
aaggaacgct ctagccatgt tttggctggt tcctttgaga tcgctgccgc cgcggcagct 57000
acttcatcat taccaaaaag aagatcgacg agtcgtttgg cataataatt aatgaattta 57060
cagttgtttt ttctgactaa gtcaactcct ttcatcatca tctttccgcc gacaatagtc 57120
ccaatgtatt tcttcttagt gatcaatagc aatctgaaaa atgttttctc acattctagc 57180
tttatcggac tggtgaataa ctctcgggta atcatactgg ccatagcatc accaacggcc 57240
actaaacctt ccggcgcgat tcctttaatg cgaacaaaca cggaatcggt atctccgtaa 57300
atgaccatgg cagaatatgc ctgtttgtct ttaacatgat ctaccaattc tgggaaagcc 57360
tgaactagca tatcacaagt agtccagtgg gtatggatgt agtcgcgtac tgatagtaac 57420
atatttcttc ctactgtcgt aaccgtcgcg gcgacgtgta aacatggcag taagccatta 57480
ctcactccac agaacccata cactgaatta cacacgacct taatagccag ttgctgctta 57540
tctaataaca aggcctgttc ttctgtgcta gttggaatct tggctcgtat tgcttttctc 57600
atagcaagcc agtcgcgcag taaaacgctc aacaggctta cgcgtatgtg gggcttaaca 57660
aaaaataaac gctgccctgc aacagtgata tctagataat catcagcatt taaatgggaa 57720
actgcttcct cctttagggt caacgtagta aagcacagat tatgagcttg gattatgctt 57780
ggatataagc tggcgaaatc gaacacggtt acgggatcaa catgaaagcc agtacacgga 57840
tctagtactt tggcgccacg ataaccgaca ctgcggccac ccttcatggc tgacccagat 57900
gtcattttag tattgtcagt ttcatctttc tcttcatctt catcgctgtc ttctagatcc 57960
tctgcttgta gcgctggagc taaatgttca ctgtctccac ctttgcctga aaaacgtgac 58020
ttattttcag gcaaaacgaa tccatgctga ccagctaatc tcaataagca agtgtatacg 58080
cgtacctgtt gaccatcaaa tactacacgc ggaagaagga ttccagcaag ctttgcgacc 58140
gccgacaatt caagatgggg aaggtattta aagaatagtt taccgacgag cactgagtcc 58200
tgaatgcagt attcacctat aagtccacgt ttagaaggtc ccgaagcata ataaacgggg 58260
atatccttat atgacaggtc tcgtttatgt tcgcccaatg cagcagaagc tacagtttcc 58320
aatttgtagc ttgatagttt aagcttttcg gtggctaccg aatacatatc cagggaaatt 58380
ataccgttta tcttaacctt actgcgtttc tggaaatggc cgccgccaag ctcccaaaca 58440
cgaaacatgc ctcctttgtt catcgccccg tatccatcga gcttaattcc ataaacagtg 58500
gtcaatttgt tatataaaaa cgcccaatcg aaattaacga tattgtaacc ggacacgaat 58560
tctggagagt attgctttag gaatgttaaa aaacatagta atagctcata ttcactgtca 58620
aactctagca cttcgggttt tattgccgct ccatctttgc cgttcaattc aatttcaggc 58680
aaatcgcacg accccaaaga aaataacaat gcatgttcca tgcacctagt ggatagtgaa 58740
tatagtatac acgatatctg aatgaccaga tcatcttcat ttgatgccac agggaaggct 58800
aattcgttct gcccaccaga tttacattct atatcaaaac atagtaactt gtagtctggt 58860
attgctccat cctcagagtc accaaccaag ttatccactg tgcaattgat ctcaacatca 58920
catgaagttg tgtggtgttc tggagcacgt acttgtatgc gctctccatt gtttccaatc 58980
ttcaaacgat accatccaaa cgtgctaaat cctatattgt ctaatatgag ccgcgtcgtt 59040
gcgtctacat tactttcata tttagtgacg tttgggagaa agttttcact taaaaagctt 59100
acatgcctac tacttcgggc cttgatgcga tagaattcgc atggtgtcgt gtcaaagtag 59160
tagatatcac agcgttcaac tatatctatt tcgaagcact ccggagaggc gttacgataa 59220
ccaaaattgc gcccaccctt tccagctgaa gaaaattcgc ccgagtggcc atcagaacct 59280
ccacaacttg atgaacgtaa tgccgttgcc atatgttcgg caagatcgcg cgggcatcga 59340
cttccgcatg cagcatccgt ttcagatttt ttcatgtaga agtattgaca tataccatag 59400
acatgaactg ccactttctt accacattcg cttaagccaa gcattgttac tattgttccc 59460
attgggctta gcaatttaac gaacctttcc gcatcacgcc cggaagacga ggatatagtt 59520
tccacatact ctaccatatc gtaaacatga aaccgtgcaa accgcgggtt aaagtcattg 59580
gcaaggaatg atctttcgcc ccatacatga gtacgttggg tccataattc catacattgg 59640
tcgtagttaa gaaattcgaa tgtcgcgcca ttgcaatacg ctataggttt cctacgcaag 59700
acacctatgt tggtaccttt gcgtttagag tcttcggcct cctcgtcgag tgatcgtggg 59760
gcaatgaact tgaattccga aatgtctgta taatagctgt atctattccc acgtaccggt 59820
cctttgcgat tgccgcgacc tgctgaccca tccaagtatg gattgaagaa gtttctaccc 59880
gactctgcca ttatattttc aaagtttaat ccacattggt gagcgcagaa attacttcgg 59940
tgttattgaa ttatgcgaga catgcgcaga atgtatttac gtcgcgaagt aattgtttta 60000
gagcaaaaga taaaaattat tctttgggcg gtgtcaaatc gtagtgtatg gccgtcgccc 60060
gtttgttttt atagcaacgg catagacatt ctattggcca catttacata aatgtaatta 60120
agtaatttgc atattaagcc ctgcctaata tttaacacat aaaagtacat gtcttctttc 60180
tctgtacatt gcctgcggca gctatcattc gaaagagtgg taatctactg acgaggtatt 60240
agtgtaccgc ggattattca agaatggaag gcgctgggaa gactatacaa ttaaaacctg 60300
gacctatagg ttatatatat gccagggacg tcaaatcgtt aaatgtggac attatatcaa 60360
tgctatcagc tcgcagcgcc gattcagatg ttgcaattct accattaata cgcggcctga 60420
cagtggaacc tgcgttcgtc tccaatgttg cagctgtggg aggctctagg acaacaggcc 60480
tcggcgggaa tggaataacc atgaaacttg taccgacgca ttatttccct aatgtatttg 60540
tgtttcatgg aggaaactgc atctctccta gtagtgccgc gccaaatttg accttagcat 60600
gcgaaagtgc cagagagcgc tttggtttca catcgtatac cgaacaagcg gatgcgacta 60660
gagagactac aggcaatgat atatgtacaa cgattggagt tgacccagaa aaaactataa 60720
tttacttggt cataacggct atgtttaagg agttggtgta tatgtgcaat acatacttgc 60780
attatggagg aattgagcgc attgatattg acaacacttc agtcatcaag attccaatct 60840
atcctataca actggtgatg cccgatgtca atcgcttggc ccccgaacca tttaatagca 60900
aacacagatc aataggtgaa ggattcgaac tgccgcgcgc tttctacaat acgaaactta 60960
atcgtctatt acatggggcc gttttaggac cactcgcggt ggccacgcgt gtacgcaaca 61020
tcgaatcagt tgcacgggga gctgctcatt tatctatgga tgaagcgcat gacggttccg 61080
tgctgcccgc cgatataaca tttacagcat atgatcaaat tgtggacaaa agctataata 61140
agtctggtcg cggtcaacga gcccaacaaa gtgcatcaaa ggagaatcaa aataacgatg 61200
gacatgaacg ccgcctcgca tcggtcatgt ctgccgattt agcattaacg gtagatacac 61260
tgctttctgc ggcaatacat gaagatggag caactagcat tggcgagtgg ccaattatgt 61320
ccatagagga tacaaagctt aaacaagaag cccttggcgc atacatggcc agatgcgccg 61380
ctcttgtttg tgcaatggtc tttagtacca actctgcatt gtatatgtca gaagtttatg 61440
acgccgggtc tccagatgcg ggcaaagaca gcggacaacc atcgttttat aggttctatc 61500
agatagcagc tccatacctc gcatcgaacc cacaaacaga cagagatgga cgcatcatcc 61560
cagaaactcg cgatcgccaa gttaactctg tcaatggaac cggtcaagac tttggaattg 61620
atcacttagc tatggcatgt ggcttcagtc cacaattgct ggcacgtatt ttatattacc 61680
tagagcgtgc cgacagtggc caacttgtcc acaaacagga gctagatata attaaatatg 61740
taaccggttc aatgacagct gatatctctt gtcaattatg caatcgcgat acgagagcag 61800
tgtgctctca taccacgctg catcgtcttc gtcacagaat gccacgtttc ggtatgccaa 61860
tacgaggtcc tataggtgtt tttggtgtag taacgagcgc gtatagtgat gttgaccctc 61920
taggcaactt tgcgccatat tccgcactta aaaaaggcga tggagaaatg gcacgcgcag 61980
ttatgcagga tacgtatcgc gcaacagcag agaaaatcat gactgaattg gaaagtatgg 62040
gcctatttga taaggaaaat cctctagcat ctgccggttt agaagcaata gtaacagacc 62100
agcaatcatt ccaggcaaca ttcacaaaca tacgtcaact tattgaacgg gaagccgaac 62160
agttaatgag gaatctaatc gatgtacgtg actacaaaat ccgcgaaggg ttaactgaat 62220
cttcccatac attatcgctt tctgttgatc cgtatgctat tggaatatgc cccgttcttt 62280
cattcctcag caaacgatcc atgctagcag ttgttcagga ccttgccctc agccaatgcg 62340
cttatgtgtt caatggacaa caagttgatg caaaaaactt cagaaatcaa tttcagccag 62400
tactcagacg ccgtttcttt gacttaatga acggcgggtt tgtttcaacg agacaatcga 62460
cggtaacgct cgccgattcg accttaaccg ctcctgatcc tactaaatcg cagactgata 62520
ctaattgtgg cgaatttgat ggtgagcttg tgcgcgtaac cacagaagta attcgcgaaa 62580
tgaagatcaa aaatcgtgtc ttgttttttg gttctacttc caacatgtct gaagctgcaa 62640
aatctagagt agccgggctt tcagaagctt atcagcgccc ggataggcgc gtagatgttc 62700
tcggtggagc acttggcttt gctctcaaac agttacacgg tgtactattt ccgaaaggaa 62760
tgccaattgg agatgttagc cctaatgccc agtggttctg gacaatgctt cagcgtaatc 62820
aaatgccagg caaattatta gggccgaagg atactgaatt aatacgattt gttaaacggt 62880
ttagtgatga gtacgctgca atgaattata taaacgtcgc ctcaacatgt gtcggcgatt 62940
tggcccagtt catgctatca aatatcattt tgaaatattg cgaccaccgc aattattaca 63000
tcaattcgat aactgctata atggctacct gtagacgccc gcgcgaccca tcggccgtac 63060
ttcattggat agagcgccct ttggcggatg ggaatgatgt agaaaaggcc gcggctgagg 63120
tattggaaac tgtggcaact cgcccccatg tgtggacaac ggcctattct tcaaataatc 63180
tagtacgcgc ggctctaacg tccagaccgt ttgttgtact agggatcagt attagcaaat 63240
accaaggaat ggccggcagt tcacgggtct ttcaagcagc taactggagt aatttgacag 63300
gcggtaaggg cgtgtgtccg ctaatgaatt ttgaccgaac aagacgcttc atgttggcat 63360
gtccccgtgt agcgtacgta actgttcaac aaggcggttt caatgccaac gcgagggagc 63420
gcacgctcgc agagcaagtg agagccatta tgaaagaagg tggcgtgact ccccaagcta 63480
ccatttttat agcagcttta aaggctttgg ggcaacgcgt acaatgtatg gataggcagg 63540
attggctttc cctaaccgag gatgaatacc tatctgagct gttagattcg atgaatacca 63600
gaactgcaga acgcgaaggc ggatggagcg tagatgctgg gatggaattg gcaaaagaga 63660
ttgaggcgac atcatctacc aatattgcag acgaaggaga tgctgtgttc gattttggcg 63720
cttgtgatgg cgataatact ttaaatatgc aagctggcat aggccagaag cgccaatgtg 63780
ttgatgactt atttgacctt ccgccatgtc atgaaaagaa aactgctctt tctgttgata 63840
tgctttaaag ttcatgttac gatttgcatt ttaatcaata aacagtttaa tttcatgcgt 63900
ttgtattttt aaggtgggag ggtcttgaaa agtacggtaa cacctacaaa cattaagatt 63960
caataaaggc gtgcgttgca gttctcaaac actatctgga aaatggaaaa aaatagaggt 64020
gccgataggc agcatggggc cgctgcggct aggcaacgtt tactagctac atttgggcaa 64080
ctacaaactt acatatttca aatagaattg cttaagcgat gcgaccccga tgttatactc 64140
ggcggagaaa ctttgcgcaa cttaaagctt aatgctatga tggtacgtta tctggaaaaa 64200
cacatcaaca cgggattcgt aaagcaagct gagatttatc tcacgccgat gacatacgca 64260
cttcatctat ctttacgata tgcaaaaaag gaaggtgagt cagtactagc tgctatagaa 64320
tcgtatcgtc tacatgggaa cattagaaaa ttcttttcag atacaatggg cctggcgggc 64380
gactgcccat atcaccgcgg cgtgtcgctg cgtacgtatg ggggtgaggt taggacagaa 64440
atcaaatttc ttcacgacgt ggaaaacata ttgaaacaat taaacttttg tcatctaata 64500
acaccagtag acgaagcaga atcatttttc gacgcgttag atggtttttt gtcattgaca 64560
atcggttcgg gtttcgtggt gccgcctcaa ctattcgacc catctcaccc atgttcggta 64620
tgctttgaag aactgtgtgt aactgcaaat caaggggagg cgatacatcg tcgcatggcc 64680
aataaaattt gcgaccatat aacaaagcaa atacgggtac gtattgaccg tgaagaaata 64740
ttacgccatc tgccgtacat agctggtcta gacccagaac gaaaaagggc tgctctggca 64800
gccctagagg ccataggaca gcgtatgcgc aatactgata gttcatataa ccaaacgaca 64860
atcgatacgg cagatgctat attagaagcc cataacgttt ttttaccagc ctccaaaaga 64920
ctatatgcta tcagtgaact tagatattgg ctcgcatctg ggtctatcgg caatactgac 64980
aaccaaacat ctatgatgtc cggaactatt agtgctttcg cggcaaattt ggatttgttg 65040
gcggagcgtg agtgtagact cgatttagag accgcagcag tagaactagc actattcaat 65100
aggactatga tgcattttga taaggcatat gctgataaca tggcagaatt ggatgtcatt 65160
gattgtcttt tattgggtag taggtccgcc tcgccggatg accagataga ggcgttaata 65220
cgtgcatgtt atgatcacca tatgtctgca ccgttgttac gtagattagc tgacccagac 65280
aaagctaatg aagatgcgct gcgtaaagtg ttagagcgcg cgtctaaaat gaactctcaa 65340
aacaatgggt ctaatcgcgg aggagataac ttacaaacta agaatacatt aggtattata 65400
acagagtcgt cagatagttc tgatacggat gaggatgaac agcggaaaag tataactcag 65460
cggtacgatt tgaatacaaa tatcagaaat acatgggaag atcttatacg aagagttgat 65520
gaagatacaa gagagcgacg aaaactatat tcagaaaagt taacaaaacg gtcacttgcg 65580
agcttagata gatgcgttcg cgaacagcgc cgcgaacttg agaagacgtt gcgtataaat 65640
gtgtttggcg agacattact cagcaccttc gtagcggcgt ataatggttt tcgctcgcga 65700
gctggggtgc tgaccaaagt cataaacgcc gccggaactg taatcgataa ccgaaattgg 65760
gatggtgctt ttgacgccca tcggttcatg cgcacatctt tactcagaca atcaatagac 65820
cctgcaatgc tgcctagtct aactcataaa ttcttcgaat tggtaaacgg tccattattc 65880
tgtcacgata ggcacatatt cgctcaaccg ccgaatacgc cattatattt cagcgttgag 65940
aatgtaggtt tactgccaca cttgagggag gagttggcca gatttatggt aacgcccaga 66000
ggggcggact ggacaacgag tacatttcag ggcttctacg actttagcgg aattgaaggc 66060
gttactgccg cccagcgcct ggcgtggaaa tatatcaggg aattaatcct agccacggca 66120
ttattttcat cagtcttcca ttgtggagaa gttaagctaa gccgtgccga tcgagcatct 66180
cccgggactg acggcgttcc tctatgtacc gacggactat atgttactta cgagacagaa 66240
tgcccgctta tttctgtaat tcgagcgggc cagaatggag aaataacccg cgggacgttg 66300
gttgtgatag acaaggacgt cttctctatg ctttatacgg tgcttcaaca actggctcca 66360
gaaacggcgg agcgtgcaca acagcagtca gaagaaagga gttcgacaga atgaaccgcg 66420
cgcgccgagt gtccgcattg cacctgacag cccctcgccg gtcacggttt gttctatcgc 66480
taatcatggt aagcgtattg ttcagaccaa ttcaaccaca acctattgta aatgcaactg 66540
ataggccgca tggactgatg aatgatcaag atacacatct agatggtgaa cgactgcaaa 66600
gaggtaaatt atcggcccgt gaattgatca gaggggtgca gtcgacgcgc gaagaggaca 66660
aattctatgt ctgcccccca ccaactggca cgacggtact acgcttcgaa ccatctagaa 66720
aatgtcctga agcatacaaa gggagaaatt ggaccgaagg cgttgcggtc atattcaagg 66780
aaaatataaa cccgctaaag ttcaaggcaa tgatctatta caagaacgta atacaaacta 66840
ccacgtggtc tgggacatgg tacaaacaga taactaatcg atataccgac cgcgttcctg 66900
ttgctctcga tgagataacg gaccgtatag atcgatttgg gaaatgtcta tctgcagcta 66960
agtacttgcg aaataatgtg tatgttgatg cttttgacag agatgagagt gcaaaggaag 67020
taccgctact agcttcacgt ttcaacactc cagactcaag ggcatggcat acgactaacg 67080
atacgtacac agtgtttggg tcgccatgga tataccgtac gtccacgtca gtcaattgca 67140
tagtggagga ggtaatggcc aggtcggcat ttccatacga ctacttcgcg ctcgcgaatg 67200
gagacgttgt caatatgtct ccattctatg gctatggacc aaccgaatct agagaacata 67260
acagctattc atcaaataga tataagcaac tagatggata caaggtaatg gacctggata 67320
cccaccgcct agcttcccca attaagagga actttcttac tacggagcat tatactgttg 67380
gatgggattg gatgcctaag cgcgaacgcg tctgctctat ggctaaatgg caagaagtta 67440
atgaaatgat gcgggcagaa tatggcacga gataccgatt tgcatctaaa acactttctg 67500
catctttcat cagcaacatg acgcaattta acttggatag attgtatctt ggcgactgcg 67560
tgaagagaga ctcggaagaa gcgataaaac ggatatttga agagcagtat gcatctactc 67620
atgttaaagc tggagcaata gagtattatc taacttcagg gggctttatt cttgcttatc 67680
agccagtagt tagcaataca ctggtgaaaa tgtatgttca agaactgacc cgagataatc 67740
gtacagagtt agctttagac cttttggggg caatgcgggg ggacaagacg cgcgaagatg 67800
gtaggagtcg acacgcccgt agtgtagatg gagggcctga cggtctaata aggggtgcaa 67860
gaaatataga tccgtataaa aactatactg taagatctgc aagggttgcc agaaatgcgg 67920
acccatataa gaacactaca gtcgttaagt ctgtaatgtc ggcccagttt gccatgcttc 67980
aatatacata cgatcatata caagcacatg taaatgatat gttgagtcgc attgcagtat 68040
cttggtgtga gttacagaac aaagagagcg ttctatgggc agagatgcgt aaggttaatc 68100
caagtctaat cgcaagcacg actgtaggac gacgtgtcgg agcgagaatg cttggcgacg 68160
tattagccgt ttcttcatgt atcgaagtac cttcgtcgca gatcagcctg tccaactcaa 68220
tgcgcattcc aggaggatcg tcatgctaca gccgaccccc ggttacattc tcttatgaaa 68280
aagacggcgg tacaatagac ggtatgttag gagagaataa tgaattgttg ctgactcgcg 68340
aatataaaga accatgcgca gctaatcaca aacggtactt catgtttgga cctaattatg 68400
ttctatatga agaataccaa ttcgtacgac aagtagaagc ggcagatata caaatggtta 68460
gtacattcgt agaattaaac ctcaccatgt tggaggatag agaaatatta ccccttcaag 68520
tatatactcg tgaggagata cgcgattcgg gcgtgctgga ctacgccgag gttcaacgtc 68580
gcaaccaact acactctcta aggttttacg atatagataa agtgatagat atagactcaa 68640
actatgcatt catggccgat ctgacgaatt ttttcaaggg acttggtgaa gctggccagg 68700
ctatcggtaa agtggtggta ggggtagctg gtgccgtagt atctactgtg tctggaatat 68760
catcactact gtctaaccca tttggcgcat tggccatagg tttaattgtc gtggctggtc 68820
tggttgtcgc atttctagct taccgataca tcagtaagct gcgtaacgac ccaatgaaga 68880
cgctataccc aatgacgatg aaaacattaa aaaatgaagc caaacttact cccaggggtg 68940
aagcggatgg tgaagatgaa gatgaatttg atgaaagtaa attggaacaa gcacgtgaaa 69000
tggtacgtta tatggcactt ctttcggcct cagagagaac agaaaagaaa gcgcgtaaga 69060
aaaacagccg tactgcacta ctttccaatc atctgtctaa cttacgatcg aggtcaaatg 69120
ggaaaaagta ttctaaagtt gaagacgaat atgaagatgg cgattcggca gatgaaaccg 69180
aaattcttgt cacagacaga gtttaattat tatgctttgt atcaataaaa attatcccaa 69240
agctgttgcg tctcattgtt gttattgtct tccctccccc gtgtttccat ttttccacga 69300
cggtcgttat tggacccacg aagaaaccgc ccaacgaaac tgtacgtgtt ttaaatacga 69360
gcgtatagtt taatcgggag gcagcttcat gtgccacgag taattgctaa agttgtcata 69420
tttgccaggc cgaatgcatt cttgccgtat gaattgcgct gacaaaatct ccgtttgaac 69480
attctggact gcaatccgca ttagaccggc cgggcagtac agaacgttca aacggaggcg 69540
ttgtgcgact ctcggtgtac gccggcatat tcatgtatag acttgaagat gctcaaaaga 69600
aaaggcacgc aaccatttaa tcgatttaat tttattgaag taacaattaa caatttagtc 69660
aacatctatt acacatcatc tgcgcgataa attcttccgc gtcacgatca actttacatt 69720
cagtagttcc tcctatagcc acgaccgcac tcgcgtctac attttcggtc tgaattgttt 69780
gtgccggcgg gtccgcttta accatatcac ttgttgtagc actctttgta tgtggctgcg 69840
cttgctgagt tgtcattggt tgtggtgggc cggcatttat ctgttcatac gatggcatca 69900
cagattttac cgcggtctgt ggttgcagat cggcttgctg aggttgggcg acattcgcgg 69960
tctggacggc ctgcgtttgg cgtagacgcg agacctcatt atggagagac acaacagcac 70020
ctagtagatt acaaatcgta tccgatggca aagctaatgg tccagtagac gtagcgttgt 70080
catcgttacc ttgtccagta ggcaccactg gccccgaata ctgagggggt gttggcatgt 70140
attgtttggt ttgctgcccc aatggttgtt ggccaccgcg tatagatccg cgtcccaaat 70200
aaactgattc ccccggataa tagatattgt caccatctaa ctggtcgtca tttgcatacg 70260
gccgttttct tccgcggcgc tggttcataa atacctggct ttggtcaaca ccgcctgcgt 70320
ggtgcggatc tccagattcg acggcttgtc cgcgcctatc tgcagcaatt gctccgatga 70380
gcgctgcaat ctgagtttcg agggaactcg gttgcgtagt ttggtatggt ataggcagct 70440
gccctccctg gacgaatggt gcctgttgaa aataaacagg ctgtccatat atcggtccag 70500
gatagggcat actaccagct gtcataaagc gatgatgctg ctggtcgttc atttgtgctt 70560
gccatgggct ttgagatgtt tgctgtaaca cttgattgtt aattccagtg ttgctccctc 70620
gttggttgct gaccaaattg ttatattgcg atactggcac ccatatgtaa tcgtcgtttt 70680
gtccgcgaga tatttgtggt ggatgacgga taatattgct atctgtcgtc atagtagatt 70740
gttggcggcg cacgatagac gggctagaac tcaaagccag attctcaggc aaaagagttt 70800
cttgcccgtc ctcctgcacc gactgacgaa tgcttccagg tagttgtgcc tcaacctttt 70860
taataatatg acgtctctca cagacgccgt tatactcctc ctctttcgat gtttgaccgc 70920
cgaagccgca gcatgccgaa gcttgcaaat atgtatgacc acgaataccg gcctgtttgc 70980
gccgttccgt aactacacgc catctatctc tcaaaagcat agtatttacg gcagtaccca 71040
ataatgcgcg cgatatagct ctatcacttg gtgaccatag tgacggaaat aatgtagttt 71100
ccgcctctgc agattcactc aaaacggcgc ggcgcgccgc gtcggaaagg tcacgaaacg 71160
gtaacagagc attttcggga gaaatatcat atgtaactat tgtaccaaca cgtctgccaa 71220
gtaagcaaag cgctacatga gaaaaaagtg acgtatccgg ttcctcgcca gcctttaatc 71280
gtctagatga tagagatgca gatggtaggt agtttgtaac tatatataac aaacgctcct 71340
cgggtgttag ggagagctcc ttgtttccaa aaatttcgcc actagccgca gataaaagga 71400
ttgttgctag tattggacag ttgatcttcc cgaggaaaaa tagtcccttg tccgggtcat 71460
cgacgattgt caatacagca ccaatgacac aatcttgcct atgatctatg tttattggga 71520
gtggtgccgg tataggtatt gctgctgtcg cgacgctacg atccatagtt aactctcccg 71580
ttccatctcg cccgtaaagc gctagatagc cagcaacata cagcggaggg tacgagtccg 71640
gactattcga aaacgatgac gcgtctcctt cagttctgtt taacaaattc tccctaataa 71700
tttcggtcga ttcgacaccg gaattgttgc cacgatcatg atcatcttgt atatcgtaat 71760
taattgcagt atcgtcgtcc atgacacgta ttttgtataa gatcgtccta ctgtcataca 71820
atataagaag taatcaccgt gacagtcatt cgtgcactgt cacattgaag acgcataaag 71880
tggaatatag cccagacata agaaataaat caaatcataa tcactgttaa cattgaattg 71940
taaaagacgt ctcccgtccg atagcgtgtt ttttagtcgc gcctgttgca tcaatgtcgc 72000
caaaccttct tcatactgca aagctaccgc atcatgtgtc gttagtacct cttgaatagg 72060
tacagatata gtcttagacc tgttttgcaa ttcgaccgca atgagtcgca aaagggcagc 72120
ctgggctcta ttcgttgaca cgtctaagac atggcgtgta gcattttgtg tttttatgtt 72180
acgtgcatcc aaacaaagag ctacgagacc aggaaacatc tgtgttatct cagtttgcgg 72240
atcagctgca tataatgaag ccatataacg ctcgcaaagg aacgcgaaat tgcgattatc 72300
gcttttcatg gtttgggccc ccgcggcccc gccattggac gcgccgcgat ttaagcgatc 72360
agatggtact gcacctggca acaacgttcc gatctgaaaa ttattacaca tgcgatccgc 72420
atagacattc gtattccata ataattttcg catgagtatc agtgatgtta tggtatttat 72480
agtggcgcgt agctgagtta tatcctccat aagaaataga ggttgggctc tcccaaatac 72540
ggccccggca gctttattta cctcatctac ataagctcgt tgactcttat caacatccct 72600
cgcaagtcca tctggggcgg ctacgccagg agacagcggc aacacaccat gttttataag 72660
catagctaga acacaatgac cagaaagggc aattcgttcc ccacttctgg gttggatggc 72720
aaactgaccc ttaggtaatc tatccatatc aaacctataa cacaagcgac cgcaatcgga 72780
ggcgagacgt tctataaaat tatccaaata agcaggtagc tgctccacca ttcctatagc 72840
actagacgcg tagttaaatg gttggcattt agtcttggca gatgtaatcc tgtgatgtag 72900
ctgtaggcat aatatcgcgc actctagagc tgtataatga cggactccta catacaagcg 72960
cccagtggcc tgtagtgata ctatagcagt agtcataaac gttttggact gccgtccatc 73020
gcgctggtct aaccgttttg acacaacagg ccactcagta atcaaaccgt cctggagagc 73080
tctataccaa gtaccgaata atacacccca accagaagcc gaagagccac cacgtgttga 73140
ataaataata gttaacaagt ctgtactcaa attagtgtca tagcgcaatg gtgtatcgtt 73200
cttaactatc tgtacttcgc gcctttcatc attagaatca cttgtttctc ccaatttatc 73260
cccatcgccg tcttgtcggc tacgttcata tgatccatcg atctcatcag ccgcgtccgt 73320
cgcttctgcc atagcagcag cattctccaa atctgcgatt actgctgtta cagattttac 73380
ttgctcttct ataggtttta aacgcatttc taattcggct gatatacagt tattcttgat 73440
gcttaaatga tccaacgccg ccgatgccgc agtattccgt tgttgtaata tacgtaattt 73500
ctgtatcgct gtttcttctt catggcgatt tgcctgcgat tttgtccagt agtgcgctgg 73560
ccaattcggt gttataaaat tcctagaatc tgatatgtag cccgcggagc tatgttcttt 73620
gcacatatca agtggggaga aaaagaatct ttccattgtt gattatacaa gccgatagtt 73680
ttaagaaatc caatacactt ctaatcgaca gaccctcgca cagctagtaa caaaaaccgt 73740
tgtcaaacaa ttctttttaa acactcgcga ccagaactcc cgcccataat aatcaacact 73800
gccagacaat aggatggtaa tatgcgtttc tgtaataatg cactagtgtt tagttggtct 73860
gaatatggat gctacaaatc gcaatactcc accgcctatt tgtgtctctg tatcgctaca 73920
attaatatca ctgtctgatg cgacgccatg cttgccatca taaccgtatt ctccattaat 73980
accatctata ttcgttttgg gttcttcagt attgtttagt cctgtatttg tctgtggtgt 74040
aaccaactgc ccataacccc atagtcgcaa tagtcgtacg ctatggatcc cagttgcatt 74100
gccgtgtggt atgttctcgc ctgccgcaga actcgtcccg acgcctggcg aaaattcttc 74160
ccaccagcgt tttttcgcaa gactggaaga attttcgctg ggtgtacgag cacatgtcgg 74220
gttcataatg gcatcatcga tgtcgtcttt gtcgacaatt ttgcacgcat ctttactgta 74280
taattcggac tccaattgaa catactggct acatatacat ttagccttcc ggcgcttacc 74340
tttggtaggt atatgatatt ctgataaacc tgcaatagag gctgataatg ccgcaaagtt 74400
ggaggatacg cgccgatgag caaatcgtgt aattcggagt atgtccagac cgcgctgggc 74460
tacaaatact agcaacggac atattaaaaa ttgactgcat ccagggggca tgatacgttc 74520
caacaagatg gccgattcca tcaattgtct aattccagtc catgtttgct gttgtttact 74580
tcctgttgtc atatttttta caaacttgca agtcttgagt tccaaaataa tacatatgac 74640
atctgcagtt tctgcctcgc ctgtcttaat catgcatatg caatctgggc ggcgccttcc 74700
taagttgact tcaaaagtca gcctcacatc aaatgcagtt ttaagtgtcc gcaaagacag 74760
agtgtgttcg aatagccgca caatcagttt actgggcgat ccaccatttg aacgaaattt 74820
gttcaaatcg ttagccaggg cgccataaaa acgattgtgg cagcgcactc cagctttgag 74880
gcgacgtgcg actgaaccgg acgtgttggc atcggttcgt ctcttggatc ctgctacgcg 74940
tctacaaggc cgctgttccg cgttcttaag tgcggctgtc gtcgctgcgc caatacattt 75000
ccgatcaaat gtcactgcgc gactcttgcg aacgcttaat ccggcgcgct ttttctgtac 75060
cttcgatacc attatgcctc gtccgcgtat acctagacgg gccgtatgga actggcaaaa 75120
ccacaactgg caaactgttg tcggaggata cccttgcagc cactctttat gttgccgagc 75180
caatggcgta ttggagaaat cattttgaag atgtaataaa gggcgtatac gaaacacagg 75240
aaagaaaagc tcgaggtgac atagcaacaa ctgacgcaaa agcaattacg gctgctcttc 75300
aactgcaatt tttcgcacca tacagttcct ttcatacata tgcatcgacg ttatttggag 75360
tcgaagcgcc agaaagaaca ccaccagata ttacgctcat aattgatcgg cacccgaccg 75420
ccgcatgtct ttgcttccca gcagctcgtt ttgtagtggg ggatatgagc cttagtactc 75480
tattggctat gatatcccta attcctcgcg aaccccatgg tggaaatata gtgataatgg 75540
atttgaatga agatgagcat cttgaacgat tgagagctcg ccaacgtcct ggcgaagcaa 75600
ttgacgtacg cttcttgcgc gtattacata atatatataa gatgtttgtt aatacaattt 75660
ggtatgccaa acaagcacca ataatgtggg actgtgataa atgggacaaa gattggagct 75720
cggtcccaat atttgatgac gatagaaaga aaatgttaga agcgcgtgat tcagtgccta 75780
ttgttggtgg gaaaaaacgg ccaagtccat caacgactct cttgtcactg ttcaaagtac 75840
ctgaactatg tgacgaatca tttagactgc gtaaagtcca tgaatggaat ctgagatgcg 75900
cattaattaa gttggcggat ttgaatgcat attttatgga cataagtggc aagagccccc 75960
aagagtgtgc cgctgaagta cgagaggcaa ctaacgcgat ggactttacg cgcctatctt 76020
ttaccatggc cggggatctg gaacaagctg ttaaccaata caataccgag atgacaatta 76080
attgataaat atatttgttt taaataaagc tctgatgggc ggttctgaaa ctatgacgca 76140
tatgtgtgtt tattgcctgc cacatttgta aatgcacgcc ttcgctactc cctatttgtt 76200
ttactgtttg gagacagtta gtatatgttc acgcgagaat ataatgcgcc attccgccga 76260
gaggacctag gcgagctttc tgggacctca ccgcggagct agttttctct acgcggccgc 76320
ggttctgtcc caggtaaagc taaccggcca actttagaat gtcgcagctt acggtgctaa 76380
tatatacagt catagttttt gaggttgtaa gtgcggcgtg gataggtgtc ggggaagaag 76440
atatgagttt aaactttact catcacgtta tatcgccaga tgttcttcgc catgccttta 76500
caggaatagt aacggacagt ggaccaactg ggcgtagcac atctacaatt catgtatcgt 76560
cggttctcgg cgcgccgtac ggaataaatt ccaccgatct gagtaatcta aaatggatac 76620
atgcaaccac aatattcttc ttcgttacca accccaaagg aacgaagttt acaggtactt 76680
tgctattcgt acctagagaa gcgggcataa aattcagatc aattgactat cctgacagcg 76740
ttatgcttgc gtcgcccaat tttgcacgtt ctctagcatg ttctgcaacg ccggataatt 76800
tatcagaata tggaaagata aaacttaaag aacacgtcga cgatataaaa catgtacgtc 76860
ctgttcggcc caagcccagt ggctcaaatc ctccaaagga cattgctaaa atttcatttt 76920
ctgacatact ccgtccttcc gaagcatttt ttgatcccaa aacgctccta ccatcagcac 76980
tggaaatcac acgcttcgtg gatccactgg cctcagtttg gccagtagac tattataaga 77040
cggcggaatt acgttttgga actgatcgcg cggaagctgt ggccaatatt ggagacacct 77100
ttatgacatt gaccctctcg atggccagtt cgcgcccaat tgaaattcta atagcgcata 77160
ctcgttctcc aatgtttatg atatggcctc gtttcgatac agtattcgaa ccgccacatc 77220
tcagcataag cgacaaattc aaaacataca tattggcaag tttcaaaaat tctgccgata 77280
acgaatttcg agacatgaca gaacttggag ccattacagc agaagtgttg gagccacaga 77340
accatatatc agaaggacat ctacaacttc tattaatgtt atccaatgca caagaagaag 77400
acgatgttta tttctggaga cgaatcgtta cacgtgttgc tttgattgca ttttctttca 77460
taactgaatc aagttcttcc aagtttacaa gtctggagga ctacatagca acggacttaa 77520
atacacgctt ccttgcaacc gctgtgtgta aaactgcatt aactggagac cctgatacat 77580
tttttatgcg aactggatta acattatccg agaaggctac cagtatatta actacacggg 77640
tcatagaatt ggtagacgac atacatcgta agagtgatta tggcaagcgc gaaccactag 77700
aagaagtact aaatgtactg cgccttgggt atggtctggc cggcgataaa cgcctagact 77760
ctgcactaga taagctctca acatcactta taagtaactt atattccgac atcgtaatgc 77820
tgcacatggg atggaacgta acagccaaac acacgttgtt ttttgcaact gagtccacgc 77880
tcggcagctc cgtccctagc atggtgaggg ctcgttttgt acttctgcta ctaacatcaa 77940
tgtgtactga tatacatgcg gcctctataa atgtaaacct gcaagaaata ttcattagcg 78000
ttactgatcg cggcaatgat ttcagtatgc tggacctatt ttctccatgt gtcacagcat 78060
tgcgatacga cacacatgaa ggaatacata aactatacgt gcttagttca attcctgata 78120
ggttacgcct cgtcgcggct ctaaaatcag acaaagatgg aggaatacat aaagaagata 78180
acctaaatat gcgtgctgag aggactatag aacgctggag gaatcaggac ataactgcga 78240
taaaacactt ccttcccgaa ttatttgact gtggagaaag gttaaatctg tcgccagata 78300
atggccttgt tatgttgctg ccattgaccc ccaacggcac ttttattatt tccagacatt 78360
tcctagacgt cggtgtaaca tatcgcattc taggcgtaga tgttaacaac cctttatata 78420
taacatttaa acatgccggg tgttcgtcct ctagttccaa tattgcgtca gtacaacttc 78480
cgcgaccagg aacaaataca gagtgtctgt actgtgggtg tgtaatcatg cgttatacat 78540
ccaccggcgc ggttttgtat tctgtatata tagccgatct ggccatgcag cgcgaattta 78600
tggccgggat aaattcttcc actccatttt tcaatcctgc atcatttggg ggtgcagaat 78660
cattactatt atttcctaac ggaacaatag ttaacatact tgccttcgaa caaaaaattg 78720
agtatgtcat accgggcacg tatatcgcga tagcggttgg gggtatggct gttgccgtac 78780
ttgtctttta tgggataatt aaactgatgt gtaatctaat tagaaatggg gacttaaaag 78840
aactgttaag caatgaagaa tgattttata actcaatgca gtctgttaaa tcaatttatt 78900
gttcctttaa ataaattatt aaacagtata taattttgcg taatttcata accaaaagga 78960
tttcggttaa tctaatacat attgcccttc gacccatcat atacgtccac attgcctcaa 79020
gtgtttgcgt cattgaaaca cacagactat cattaattat aaccaatttc agtaaactat 79080
tcaaatatat gatcccgtat acataactga tatattagaa tctttactga tataaatact 79140
aaaacacatt accctaatag accggcgttt tttaagcggc gatcaattaa cgcgccaagt 79200
gtcaaaacac ccttttgaat atcacatttt tcatcaaata ttgacgagca catcgcgtca 79260
attgtagcgt ttaatatata cgagttccca aaacatctat cagtgcgtat tgccgtcttc 79320
attaaatcat tagtcgtata aatttctgcg attattgaag cgagacgcgc tatacgttgt 79380
aattgaatag actggtgttc ctgggccgtg tccaggagat cggtagccat ttcaaataac 79440
gtttctgcat catccatcac cgaatcatct tcatctgttg caacgcgcaa ctgtttgacg 79500
cgcgttgata atatagcgac ggaagatgcc cagattatgc aagattcgcg aaaaagtcta 79560
tttgtcgtat ctactagcaa atgtatatct ctgggcggtt ctggaaacga ttccgagtcc 79620
gcgcttagac ttacgcataa atgctctatg attgggtaac aatttggata gccgccttta 79680
cacaatatat actgaaccag cgcaaacttt tgtgcgctag aaactgaacg tcccatggaa 79740
taaccaacga atagttcccc aatgttgcca aaagatgctt ctattgcatc gccaattcta 79800
gctctagcgt cattaaattc gggttcgaga ccaaaccaag tactaatatc ctgagagact 79860
acatccccaa tcctacaaaa tacggtccaa agggccccaa gcgatcgcgt aggtttgaaa 79920
ttaccggcac catattccca tatattaagc acagcgggaa tgtattttac ttgcacaaat 79980
gaactgacag tagttttgcg tgcgccgcga cgtgaatgtt ttcgagaatg aagtgtggtg 80040
gtaatgtcgc agtcatcatt tgtgtttaac gttccctccc cagagccgcg atgtcgctcg 80100
ccatgtccat gctttaccaa tactgttccg aaggagcgct tgccagtaat tattacatct 80160
gtttgttttg tttcttctcg tactccccta cgtcgaacgg ctatgcgatc aaatagtcca 80220
tcgaccatag cggcaagtga ctgcggcaat gatgtaagac gcgcctgcat gagcgcaaat 80280
gcattcctat ttggttcgta aataaaacca gaacttgcat tagtaataat tggtacatca 80340
tataatttga taacttgata gttcgaaaat atatgacccg ttgataatat caggcctgac 80400
gatatttcga gtgaaaccat atactcagcg atacactggt cgcgaacttc aacctcaagc 80460
gccccgcaca gatcacgctc agtacttcca tcaccgctat ttgtcccgca gagatcgcgt 80520
tcgctacttc cagaagtatg cccgagtaaa tccaaactat ctataaagac ctcaccatca 80580
ccaatgatcc atttcaaccc ccgccgtcca agttcacttc ttacataatt tgacagtacc 80640
aaatctccgg aggttatccc tcgtaatgct ataccaaact tggccaattc ggcttgtgtg 80700
tcactgtcat tttccggcgg gcgtggtact gataatatac agccaccaca tgcgaagtat 80760
gctctcatgc cgtcgcgtgt gatatagaat gttactccat tgtggtttat ggtctcccaa 80820
taatgaaatt ccatcgttcg ccgcaaaggt acttccttaa agcaaaagta ttcctcctaa 80880
caacctatta tactataaag ttaacctatt agaagcctaa ccagtacgtt cctggatgtc 80940
gaatggttct aggctaagcg acaagcgtca tttaccgggg gcacaaacgc ccaacaaaat 81000
cacagcgacg acacgtagac gcagtgggcg gtcctagatg tttatttcgc tattttaccc 81060
cccgagagaa tattaataaa caattgtcaa gaggattatg tgtgaggact atttatttct 81120
ttgtcccttc aacaacaaaa cagttaacaa aaaatagcat accaaagtgg tttggacgca 81180
aggcagctat tggataatac attaatctta gtacctcctt taaataccag cgcgtttgat 81240
attgggccaa cctcgagcat actcatctta acctttacaa ctagatatgg cattcgatgg 81300
aagacactca catgcaagtc ccatctcgga aaacacagaa atgacttcaa acagaaataa 81360
cagtgaagca gtagatagta atgagatcgc gacatgcaat ggtggtgaca gatgttcgga 81420
aataacaacg actgtcaatg aagcaacgga cataatagac gacctagaaa gcgttactga 81480
atttatggca ctaacatcat acggctttga cgcagacata tacagcactt cagcattctc 81540
tcaagtaccg gcgtctgggc atcctgtttt cacacgttat gtagtaatat tttggctatc 81600
cacattaata atcaagcctc tttgttgtgg agtttttgct atttattatt atattaccgg 81660
cgattacaga tttttggcta ttggactcgg ggcgacagct gcattctacg tacaactgtt 81720
tcttactgta ctgtttattt atatcaacgt acgcaaggac ctcttaccgc tgaaaggttt 81780
gcagcgcata gttgtcggta cgatagcgct ggcatgtccc gtcgttttcg cagctactgc 81840
ctatacgttc atcttccaac aacctgaatt cttcgaccgc atactatatg cctcatttaa 81900
agacgattcg ggttcatcgc ggctggtcca tttcgaagaa gcatatggac ccataagagt 81960
ggatgctact ataggtgcgc gcggcgcgtc gtgtattact ctaatagcag taattatata 82020
cgcaactggg tcgctagggg acgctttagg tttcctactt ccgcgtcttt ggacgagggc 82080
ggtaatgaaa acctgcgtgg gattttgaac gcactttcgt catcgcctat ataagccaca 82140
tcgagacggc caacatttta tttccctaaa gcggccagtc agtggctgcc gtcagtacat 82200
tactgataaa gactactaaa tttctttcga tcatataacg cactgtcaac gaaataatcc 82260
tgctccaaag atggataatc aacaagagag aggggagaca cgttttaatg ttggagccag 82320
ttatgcacca acgggacgcc ttctcactac aatagaggtg tcgtctcatc gcactctgtt 82380
tgattttttc cgccgcttca gttccgattc aaatactcta tacgaagcac agatggacat 82440
gcttctcggc gtatactgca atacactgag cttggtgcgc tttctagaat tgggtctttc 82500
tgttgcatgt gtttgtacaa gatttccaga acttacatat gtgaatgatg gtaccattca 82560
atttgagact caacagccga tgattgcccg cgatggaccc catccagccg atcagccggt 82620
tcacaattac atgacaaaaa gtctcgatcg gcgatcactc aatgcagcat tctcaatcgc 82680
cgccgaggca cttggcttac tatctggcgt ttcgttcgac gggacccaaa tagctgaaca 82740
tctacgcaca agggccatac aacagttggc caggaacatt aatgcagttt tagattcatt 82800
cgagcgcggc tctgcggacc aaatgctacg tattttattg gaaaaggcac ctcccctagc 82860
tctattgggc ccactttcac gttatttaga tgaaggtagg ttatcaaacc aagttgcgcg 82920
tgctaattta atatcagaac ttaaacgtcg tgtatgcgag gatagttttt ttatgagtaa 82980
atatgtcgcg aacagagatg ctataatggc gcaactttct caactagtca gctcaacgcg 83040
cccgtcagta gccgtacaaa gactgacaca ttccgatacg tctggcagac cagtagatgg 83100
tgtaattgta acaacagcga cagtgcgcca gcgtctacta agtttgctaa atatggccga 83160
taatcatgcc aatgtccccg ttacttatgg tgaaatggtc gtgactggta gtaatcttgt 83220
aactgcagta gtcatgggaa gggccgtacg caatcttgaa gatgtcgcgc ggcaccttct 83280
taatctacgt gacgatagga tattgaaaga taaagatggg ccgatcaata cagatgatga 83340
cgacacccca cggatggcac gtgttcgtgc tgatcttgct tttattggag aaaaactggt 83400
attcatagaa tcgttggagc gtcgtatata tcaagcaaca aatgtgtcat atccattaat 83460
cgggacaatt gatttgacat ttgttatgcc ccttgggtta ttcaaacctt tacaagataa 83520
ttatgcacgt catgccggtg attatgcccc aggtgcgggt caagttgata cgagatcgtt 83580
tccgccgagg caaatactat tttataataa ggatggacaa cttatcaaac tgacactgga 83640
agacgccatc ggaactgtat gtcacccttc atttctggaa attgacatgc cacttgattt 83700
cctacgagca acaccacgag acctgcgttg tccgttcggg gcgtacgtgg cagtccaaac 83760
tcaagaagat ttggccgtgt ctatgcggcg tttttttgac cgctggcttg attatatgcc 83820
agatacacct agctgggtgg cagtggagac ctatactgtt gatcaaatgc tatcacctgg 83880
caactctcgc ctaccttttg aacttcaccc agcttttgac ttctttatag cccccgccga 83940
tataaatttg cccggtccgg caaacattcc gcaggtcatg gcaacggtca atgctacgtg 84000
gcgcgtatgt aactgcaaca tacctctacc tctgtgtcct tcaaacttta gagacgccag 84060
aggtcaagag atatgttcca accgccatcg catgagtcaa gctactattg atgccgtccg 84120
atctacattt gcggatgtta attatccaac agtattctat ataattgaag ctattgttca 84180
tggcagcgaa cggatgttcg gaatattaat gcgattaata atgcaatgta tccgcggata 84240
ttgggcaaat gggcgccgtg tcgcatttat taataatttc cccatggtta tgtatataaa 84300
cacctatttg ggaaatggtg aattgccaga agagtgcgct tctgtgtatc gtgaaatagt 84360
cgatcattta cttgctctgc gcagggtcat aacagattat acattgcatg ccgataacat 84420
tggccgccag ggacaagaag aactcaacaa cataatggcg gatcaatcgt ttttaccacc 84480
attaatttgg gacggagatg cattaattta tcgctatcag gcagagcacg atagaaacgc 84540
ggcaataata gtaggtggag aggagggatt cactctacgt cccttttctg gactgaatga 84600
tattaacttt gatagaacag gcaacagttt aatacacaac gcccatattc gtgccgacgc 84660
cggcaatata caacacactg aaccgcacca cgatgcagag tgggtaatac taaacaagct 84720
ctattacttt gtgatggtgc caacattttc aaggggccga tgttgtacca tgggcataaa 84780
ttataatcgt gtatatgcaa ccgcccaggc ggtaattata ccagatttgg cagcggacga 84840
agaaccacca attggacccg atgatgcgag acatccactg aatgcgcgcc atctcgtacc 84900
caactccata aatgtactgt ttcataatgc aagaatagtt gtggattcag acgcgctgct 84960
gacattacaa gaatccgtcc acgagatggc agaacgtact acggcaatac tatctagcac 85020
agggccggat tttggggctg ctactgtcgg gaccagtctg ctgcgtacat acgatggaac 85080
tctgcaccat ggactattaa tgatggccta tccgcgtaat gatgaaactg tagcagctgg 85140
aacttttttt tatccagccc ccgttcatgc gctctttgca tattatgagc atattgcagc 85200
atttaatggt ctgcccaggc gtgttcatca aaccgccaga cgagtacctc ccgtacccat 85260
ctttctaggc gcaaattact atgcaaccat tcgccaacca gtgttacgtt atgtcacgga 85320
aagcagagcc gacgagaatg ctctttccta tgcactttta gctggctact tcaaactttc 85380
ccccgtatca ctactgcacc aattgcgcac tggtctgcac cctggatttg ccttcactgt 85440
cgtcaggcaa gatagattcg taactgaaaa catgctgttt gccgaaaagg catcggaatc 85500
ctacttcatg ggtcagctac aagtctctag acatgcatcc gccggcggaa ttacatttac 85560
actaacacag ccacgtgcga atgttgacct tggtaccggt ttcacagctg tacatacgtc 85620
ccccctactg agaacaccgc ttacggacat gggcaatgct acccaaaatc tatttttaac 85680
cagggggtct gtaccaatga tagatgccga cgcagatgat tttattaggc gtggtgcgac 85740
agctgggcaa agactagccc cgcgctatca agtaccgttt atgggaacaa tactaccatc 85800
gcagccatct gggctggatc atggccaaca atccgtttgt gaatttatcg ctaccccagt 85860
ttcggtggac attaattact tcagagcgcc atgcaaccca cgaggcaggg cttcgggatc 85920
tgcttacgca ggcgaaggag ataacgatat acgtgatgtg atgtatgacc acagccaggg 85980
cgatccgtca tatccatttc gggcgacaaa caatccatgg gcttctcaag aacaatcata 86040
tggcgatcgc ctttttaacg gaaaatataa tttaagcggc gcatcgcaaa tatacagtcc 86100
gtgttacaaa ttctttacac cggcagaggt agaaggaaag aggaaatgtt tactcaagat 86160
ggtgcttgaa gctggctctg cgttagctat gttccccggt gatacggaaa cgcagtttaa 86220
gcgaccacgc ggttctacag aactgaccga agatccgtgt ggccttttcc aggaagcgta 86280
tcctatacta tgttcgacag accaggcgct gctgcggacc gttggtacca gtgatattgg 86340
aggcgcggaa acgcatctgg ctcaatacct aattcgcgac gcatccccca tcaaaggctg 86400
tttgccaatg tgataaacac ccacaaaagt gaatggaacg cccccaaagt catgcacatg 86460
tttgtctact tcattaaccg gcggcgcgac gagagtatca gcactcatcg gcgaggtcgg 86520
taccatcaac atgacgacag aacagtttat agtggaaatc attattccat cgggtatatc 86580
gcatgcggac acatcggcac tgcaaaaatg tgaaggtaga attatatttc tttcgtccgt 86640
ccggcgtcgc atagcactca gtgatattga ctacaaatca ttttatacta atggaacaga 86700
accggacacg ctcgctttac tagcagcatt cagacgtcgc tttgcggctg ttattacccg 86760
tatcatgcct gggaaaatta ctgcggtggt acttggaatt ggcccgctta tctctggcct 86820
ttcgcttcag aatacatctc catttgacct aataaatgga gactctgtat gcttcttgcc 86880
cccaatgttg ggcggtggta ttggagatgg acgtctaaaa cttgattcta tcagtacaga 86940
acttatattt cctatgacta taccaggctc gatcgctcgg gaaatcatat ccaaagtagt 87000
ggctttgtcg ctaggggcgg tggtacaaac cgcccaaata caaccgaggg gtgttcagcg 87060
tgacaccata cctatacatt ataatggccg cagatataac ataactcctt caattcagaa 87120
cttggatgct gccgaaagcg ttgcaagaac gctcgtcttg aacatgatgt ttgcaatcag 87180
cgagggctgt atgatacttt tcgcactaat tcctcatctg ttgacgctca gcggacagga 87240
tggctacgtc aacgccttgg tccaactcca aagcgcagcg agggccgcat gccaattaat 87300
gaacatgcca aggcaaatac cacagataca ggatggcgac cgacgatttc caatatacga 87360
aaccatatca tggtggttaa acatgacaac cacactcaac gaaagtttgc gaccgcgtga 87420
gcaagtacga gtatgtgtta tagaaggacc gcctactatc aaacccggta atatggctcc 87480
tgtgatagat aattattaac attaaaatga ttatttttta tgcgtaacaa taaaaaagac 87540
atttccaagc aatacttgtc tgtcttgttt atttgttgta caaaaacata cctatggtac 87600
atatcctacg tgcgcaaaac aagtctcatt gttcgggaaa cacgccgcta gatacaatgc 87660
catgacaagg gccactagtg tatcatcagc acagccaccc gttttggctg taaatgtccg 87720
ctgctccgat ggcccggata tattttctga tagatttttc atttgtcgtg ttagatattc 87780
aactggatct gtacgtaaac tgatcgtagt agatactagt tcctgcgacg cgagcacatc 87840
ccctgagtta aatttgcgga taaataaatc aaaggcatca gttttttgtt tgtttaacag 87900
gaagaatgga tatgctacat ctccattggg aggcacgcag tggtaaaata atacagattt 87960
gggggctggg gcagtgcctg atttcgcaaa ggatgtaagt tctttgcaga tacacttagc 88020
tatagccacc gcagagtctt ggttactatt tccttccacg gctatacgta tagtaccaaa 88080
tctgcgttta tgtaaggcac agatttgtgc tatacatata gcagtacaca atcctattgc 88140
cgttgcagaa tctcccgtta gagcgcgtag aaaaaaatgt tccaacccgt atattacaaa 88200
gtcggtttta tatctaccta taacagcgat tcctgtcccc gatgctctag tattggccga 88260
gaaggccgga tctacataca caaatagatc ttgactcatt atttccatgt ttgcaacagt 88320
agacggtctg taaattaaaa atcgatcaag tgatgaataa gtaaatactt gcgcgtttgt 88380
tgacttttca ttacccgcta tctcaccccc gcctataatt tcttgcataa atgaatcggc 88440
cataaacatt tctgccgtac gtctcatagc cccatccata gttataaaga ctggtttgtt 88500
taggacgtaa catgagcacg acgtggcatt tgtatggttt gccactctgc gcatgtggtc 88560
atcacatata tacgtaacca cgttaagcaa ttcatcagtt gcgcctttga ggttataaag 88620
gaagctagtg ctactttttc cagtatttgt cgacgagaca aaaattatct tgcaattagt 88680
ctggttgaga aacccgacga tagtctgcac ggcatcggat ctgatgaagt tggcttcgtc 88740
tacgaacaac aggttaaaat cttgacctcg caaactctta gttgttcgtc gatagaagag 88800
aaaagaactg ttaatataga caggccatgg aatcgcatat aactaatgaa ttgatgatac 88860
tactaccgcg aagacgaaat gataaaacgt tatctttagt ccatatcatt ctgagcgatt 88920
cgtgccttac gagctgtggt ataaatatta gcgatttaaa aactacacta tcgcaaggac 88980
tacgcgcgca tctgactgta gaaactcaaa caagacgaca cgctactgga gaatgctcta 89040
attggaaagt aatatcagct gtctacgtgc cttcgaaagc tatacgtagt gttattatac 89100
cgtctgttcc taaacatcca actatttttc aatcctccga aagcgaagac agtgcagatg 89160
gggggctatt cgtctcttta ccgattgtat tagatcatga aggcagatat gatgccttcg 89220
acgttgtagc aatacgtata actatggata gagagaagta tgttgatata ttgtttacat 89280
atgatgaatt attaccacct ggcacaatgt atagaaagga tgaccggcgt ctcaggattc 89340
tttgtaagcg attatgtgcc tatattagta gtcagccgtg tttggaccca cgcctaattg 89400
aaataggtgc gcgcttggat gcatgtttat cacaggacac agactgccca atagatagag 89460
atgttgtcga ttcgtcaaaa cgcttgcagt ttgacggcgc atttgacagt ccacaaatag 89520
aatcgcggat aaatgaggac aaccgcgaaa ttatgtctct tatacgacgc gcggctgaag 89580
ttgttaataa gaaacgaccg atacgatctg ttaactccgc cgaacttaaa gttgcatctg 89640
gtttacggca aggcgtacgg gcatatttga gcgaatatgg gccatctggg actactggta 89700
gtaatagtgc tcaaagtcgt catagtacag caattgacca agcggccatg ttatcggggt 89760
tggaaccccc gggcgagact agatattctc gctcgcagac taattatcgg accaataatc 89820
attgtccatt agaggatgta cttatgctta ccgacaaaga caatgcacca ctttcatcct 89880
tagacttgtt cgatatgggg atgtgtgtga tttctggagg tgatacgcca gctgatctat 89940
ggaaacgtcg tgccatttct atcgtaccgc gcaggcatta tacatctgga aaaatttttg 90000
taatcgtttc ctatgctctt tctgaagcat ggggcgggca agcagacaaa gacagtatta 90060
atgccagtct gacccaagaa gtcatggctg cctgcgctag cgctggagta gattctccta 90120
ataaattgtg caaacgagct cgtgcggatc tagttgcgcg ttttcctgct ctggctggtt 90180
gtctattatc atcagatccg cctctcagac catttgatat tagcgcggaa acaatcttcg 90240
caaataaatt ccatactgct tgtataggtg ccattgcggc agcattgatg gaagtatgtc 90300
cgacaacttt acgccaagta ttacgttatg atatttcatg taaccagaga gactacatga 90360
aagttattgc agatacatca agtgatatga tcgaatccag tctaacagct tttaaaaatg 90420
agccattgga gttatttatg cagagcgctc tagcagaatc ggtactcgca tcactttgtt 90480
cgaaatccga gtggtcgtat caaagatact tcgagaatag ttccttgatt acatcgccat 90540
caaaaacgac gtttaaattc gactatttca gtgccggagg cggatgtata aaagtgtcta 90600
aaagacccat acccgtcata atcatcggca atactaatgg aatggaacag tgttcatgtg 90660
aattccaaaa taatttttct agtaaatatg tatgtgaacg gtatcttcca ggcgaatgtt 90720
atgcatacat atgttttggg tttaaccacc tcctagacat cattattgtt ttgccgggcg 90780
gttttacgct ttctactaat ttggccaagc attttaactg gccagatgac catatagatc 90840
ctattttaac tagattctgt aggagagttg atgtgtcctg acattcgtag gcggtacttt 90900
ctaacaataa agcgtgccac ccacagtcgc gtatatcata ttgttaagac ggcctgcggc 90960
ataatgacat ctaggaccgg acgcgataac tagatttttc gtcattcaag aattttgctt 91020
tctgcaacca tacgcccacg ctccagctaa accacctagg aattaatatg gctcgcagta 91080
ctattacacg tcgattatca tcatgtacgg aactcgacga tggagaactg aattcgccaa 91140
tattattttt aaatgacccg tctctcggta gtgttcacct agctctggca ttgaacacac 91200
aagtgtgttc atggcgcctt attagatctg attctcgtat caagatcatg atcgcaatta 91260
cagcactcgg tgaccgtctt tgtgctttcg cgcctccact agaagatcga gaaagggcgg 91320
caatggtgga aataatattg tacttaacgc gtcctaaagc gttagctctc ccatctggaa 91380
ctttccatgc cgtgtttatt gtcaaccgtt catcaatgta tgctgcaata gcagctatac 91440
atatcgaagc actaaaccaa tctggaaccc tgttctcatt attgttttcc tcagtagaaa 91500
cgaccccgcc gcctccggaa gttcctgacc cgtcgacaga aattatgccg caggcccctg 91560
cttcaatcct aaatctagaa gaccatacgg aaaatataac gccgccaagg gatcctcata 91620
actgtagaat ggtatctgtt ggggcgtggt ggtcttttcc caaacgaagg ctctactatt 91680
tacgaatgga tacaccactt ttagctatat gcccggcggg atggaaagca agaacgcttg 91740
gagacgttct agcgagactc gtagaccata caccaggttg cgagacctgc attagcggcc 91800
acgatcacgt ggattcgtat aatgccatat ggaagcctgg cgaagtcgca gaggcatgtt 91860
tatgtaaagg accatgcctg tggctcaaat caaaacagcg ggatatgata gtagaagggg 91920
atgtgagtat gtgtcgcgtt ttgttcatgg acgctgtaga tactatacga cttgtatcta 91980
accgtaatcc acgtatttct gcaaatttgg ccgaagtaat ttccgccttt ggttcagcca 92040
gacaagtacc tgtcaatgcg gccggatggc acttggtggc gttatcggaa attgctagtt 92100
cgatcatgat atctggttgc gcgcgtctta gacgtctatg ttatcccaaa acataatata 92160
ctgtctaaaa actattgctg tatggttatt aaataaaagc attactcaag actcaaggct 92220
tggcaattta actatatacc gcgcatgatg ttaatactta catttgtatt atggctcgac 92280
gcaaatgtta cggtgctctt tgaaccatct tgaaacgaaa aagatatagt ctctcccttt 92340
atatgctcta cccttccatt tccgaaccaa cgccgtattc tagcatcaat ttcatcgaat 92400
actggctctg tagccttccg tatatgtgca gtatagccta tctttattcc tctaaatttg 92460
gtaagagcta acgctattag tggcactata aaccatgtct tcccatggcg acgtggtacc 92520
agaaatactg tggcgcgttg gcgaaaatgt ctcagcgatg tttcagaaaa taatggtata 92580
tcaaagacga tgcgcagaaa attatcagcc ttatcggcat gatcaccaag tattacagat 92640
gcgaggaaat aggtcgcatg cattaaaatc atcttctgga ataattcaag agtaccgcgc 92700
atctttccat aagttggcac atcgacctta cttctctttg cctttatagt atttgcatcc 92760
gtcccagcat cttggaaaga tgtatccaat aaacgagcga aactatttat aaaaccattg 92820
agttgcccaa attcatccga atcgcgcata gctttaaatg catttaacac actatagtat 92880
gcattcttat gtgctatcgt ttcttcctct ccatattctg caaatcttaa cgattcaaac 92940
gtttttatca tatccggcac aaggaatgct tctcgtaccg gtcttttaaa cgacgccgtt 93000
tctcccgact ctgaggaact gtcagaaagg agactagaga aacgtaaata tctggcgacg 93060
ccagaaaata ttggtgcatg ctcgcaacag tcatgaagcg ttccaatggc cggaattaca 93120
gtttgatgcc gtcgaggtac acaggtggca aagtttaaaa acggaacggc gatatcacta 93180
tcttcgagat ttgccgtcga agaacttgta tcgccagacc catttctttc ttcgtatttg 93240
cggcgcaatt cttcaaaata ttttctactc tctctgccga aagttgcccc gaacattatt 93300
tgcaatgtat gtaaaaattc ttcacataat acgccactga tcaattagta aaaatgtcat 93360
gcgtttctga ctaagtagta gggcggtaca acctgataaa ttcaagcgtt ttacactcct 93420
cggcacaatt tagattggcg aaaggctgca atacggacta ttttatacag caagtgtaag 93480
tagatatatg gggtataaca caaacatagt cgcatgggtg tgggtaagga ggggtttaag 93540
gcaaagaaat atgatttgtt ttttcctact ctattgaata gtgcgcactc tcgctaacat 93600
gctatcgcgg cttcaagatc gtcaaagacg tctcagattg gccgaggccc ataaacgcga 93660
agaggtttac aaagctcgcg ctttggactt gttgcgggta ggcgtggata aaaatagtgc 93720
cgtgttcgtt gacactttta cgtcagcgaa agcagcccac gtggcgtact gcgcccaatt 93780
gcgctcaaat atgcgcgttg aacaagtaaa gcaaaaggtg agaactgttc agacgaagat 93840
agaagaacaa ctcgcaataa aggatgcgct agaggcgcac agaaggtttt tatcgccagg 93900
cctaattgat cgtctagatg atgaagaaga taaactcgca ataaaggagg atttattaac 93960
tgaagttgca gaaaggtgtc taccgggacc cgaaaacact atagggggac tatctggtaa 94020
cgaatggctg gacgaagacg acgaagccct attagcgaaa tgaatcctat cggaagctcc 94080
gccaagaaac aacgatcttc ctcaaagccc aacacaagcg tatatgcgtt tgcctgggtc 94140
ccagacagca ctgaaaattc aatcgaaatg cgcgactgta gcgaaagccc caatatcacc 94200
tcagcaggaa aacgacgatg tagcggaata cgccgacttg gaggagcgac tgtgtattct 94260
ggagaacata acagtaaaga gagaaaggat cctggcaaac gtaagacaaa gagtagatgg 94320
agcctggctt cgcggttctc gctcgtctcg cctcccgggg ggaagccact aacacgcgca 94380
cctagaatgc catcttatat tctgcaagct acaaggatag aaaatgtatt caatgtagta 94440
ttctctataa atccctcgtt gcattttact tctgtcgcac taccagaaca gccttctttc 94500
ctcggatccg gtggctacgg agaggttcag ttatacaaac gcaatggtat cgccttaaag 94560
acgtctagac aacatttcag aggtgaattg cttatgacat tattggctag cgaaagtggt 94620
ttgagggcca aaagtatcat tggggaagat cgtattatta ctatcttagg tttttcacta 94680
ccatacaagc aaatgatatt caaagcatac gatatggata tgaccttata ttcacataaa 94740
ctagcaaaaa ttactccgaa agcccgtcat tgggctgcgt tagaacgcgc atatattggg 94800
ctggcaaagg cactaacatt tcttaacatc agctgcggat taacacacct tgacgtgaaa 94860
agcgaaaaca ttttcataaa cgttgtcagt ggaacggacc tagttctatt agatgcagta 94920
ctaggcgatt ttagtctcat gttactaaat gctaattcaa ctattatgag atctgaattg 94980
gaaattcaaa caggagccac caaccctacc aagatcagga tttatcgtcg taatgtgcag 95040
cctatttttt gtatggtcct ggggcatgca tatgcccaac cgccagaaat tttactaaat 95100
gcactaaatg gtgatgggct gacgacacca atagaaccaa ttaatccgga ggaggggctg 95160
gcaattgaca tatacgccct tggccaatca ctgattgagg tgttgattaa cgcatcttta 95220
aatcctctaa acagacttgc gttagtccga aatccaactt acttttattt tcatcatcaa 95280
gtgaggagag attttcttct ctctagtttg gcgtaccgtt gcatcttctt tcgtcgtata 95340
tttcctacga cagacctaac gatccaattt ggtaatccat ggaataatta tgacgacata 95400
cggcacaaat taagagattt ggaataccgt ggttcatttg gagcacatta caatcgattc 95460
aatttgacgc acggaagact gtttgatgaa ctagtgattc ctcaaagtat atcacagtta 95520
ctggaacttg cagctctttt ttgtcacgct aacccaaagg cgagaagcgc cgctcctcta 95580
ttgtggattt ataactaact accatgagtg gggatataga tggtagctca tcgccagtac 95640
atcactgcaa acgtcgtcga aacacttcat ggaatagttc tcccgagaat attggcaacg 95700
cggacgaaac gtacggtaat tgtgattata caacacttgg agaatctaac gaacatacta 95760
gtaataatga attgtgctct attgaacatg actggggtta cgttggacgg tttggaccat 95820
tgccggactc actaccacaa tgtattcatg agctcaattt tcatgactat ctagagtcag 95880
aactgaaacg ttctgactta gcgttagatg taccaccact gtatcaccgc ttagcatttt 95940
ttcgcgattt aattttaaag ttggaagaga ttggtctggt gtttggagca gcacctaaac 96000
tatttggagg ggcgcaagtt tgccgtaaac ctgcagaggt attgatgaat gcaataacaa 96060
aagatcgtgc catgaacatt gcattgactt ttgaagctga gacgcgcaac caagccaatt 96120
gtgatctttg gaaaatttta agacgctgta tgatgaccgc gtcgtctatg aaatggaaca 96180
aatatgggcc gtactatgag cctgaatggc aactagaaga tacgaagatg caggaaatgt 96240
tatctgtgcg tagcatacta ttcggaaata ccaatgaacc gctagtccgt gcaatgatta 96300
tggcctatcg tttaggtcca agcattccta aaacccccga tgggttagac ccgagtcatg 96360
atggtgtatt tgtatttgac gacgaaaagt ctccagagcc atatacatgt ggcttattgt 96420
tagatcatcg tacaggaatg atgggagcgt ctatggatat gcttatttgc gatagagatt 96480
cgtctgggaa gttagcgccg catcatacgg aaaaaactct ggagatatac gagataaaat 96540
gccgcgccaa atacatcttc tgcgctacgg atataacaaa taaaaccgcc cgtatgtaca 96600
atgctcttat gaaagataga tctttcaaag catttaagcg attcattaat tcaataagca 96660
agccgtgcat cgaatatttt gatccaaaac gcctaccaag tgcagccgaa gcgctagtga 96720
cgtgtgatga atcatggaag aggcgtgatg acacggcaaa aagagaacga tgcttccata 96780
ttgatagaca ccacctgtta ttaaataagg cgggtcggtc atcagttctg ttatttagcg 96840
aaccgaatct agatactcga acagtctgcc aggccccctg ggcggacggc tcgctgatac 96900
tggagacgcc agtatttgct aaccccaaac attccaactt taaacagatt ttcgtacaac 96960
actatgtatt atctggctac tttccggaac ataaaataca gccgtttctc gtaacattct 97020
ttggccgtgt tcgcaagcca gaagaagtcg gtattcgctt cgaactatct gggacattgg 97080
gagtattacc ttacgccggc tttgacttat ctatatcacc agaacaggcg ataccagtcg 97140
cgctcatctt tacgccagtt gaagtagata ctgctctatt tgaagtaata gaaaaagctg 97200
gtttgagagc cttcgatacg acagctacac aactatggga caagctcaat cctacgggag 97260
cggtggatgg tgctgcagaa gaaacatatt aactactagt aatggcgatg ttttagacct 97320
tactgccgac agctttgaag atttcgaact tctcggtcca accgacaatg acaactttga 97380
gacgagtaag accatcgtaa cgcaacctca aagaaacacc aaaaagggca agaatgacta 97440
cagcggtaga aaagataggc gttcttgtta tagaaacccc aaaaatgatg ctttgtaaca 97500
aataattaat aaacgctact ttcaatgaat gggtgttgtg taatcattaa aacgttaatg 97560
aatatattgc taatagaata aacgggactc aataaacttt ctaaaacttt tattattcaa 97620
accattctat agttattatt ctcattcact atccgacgag aaatgagtct cagctacagt 97680
atcatatatt ggctcttcct cctcatcttc tacatggttc tttgaagcac gcggtccgcg 97740
tccttgtctt ctggatccat acatcttcac tttatcccgc acgtctcgta cgcgtccata 97800
aaaacgcgta acgtttcgcc tatggtatat atatgctcta aatatacgta caagcatcat 97860
aatcaagatt atggtgctta gtattccgag cgaaagtctt acgaataagg ttattccctg 97920
tacattttct cccaaggcat aataaaacct gttcagatag tcgtgggacg atgtgccaat 97980
catcccacac cccgctaaaa gaccaatatg ggcgccgata attacatgca cgtagcgcgc 98040
aactacaaac tcgacggcca ggaggaagaa aatagttatt gcgataaaaa cggaaattcc 98100
gactgttata ggttgccata gttgcataga aaaactgttt gccattaaca tttccaacac 98160
aatagccatt atgatgatcg acaatccgta aagcgccgag ataatgttta taatcacagc 98220
ccttacattt ccggctatta tatgcatccg cgaactgagc gatcgtagtg ttcttacgtc 98280
gtcggcatat gtcacactat ttactcctct tccacagaag tagatataga agaatgtaaa 98340
taaaataaaa tgtaccaaat aagtacatgc cgcgagtaca attagcttat gggaaagcaa 98400
tactactaca gtctgtaggg tccacattga taagcttcca actaggatag ttgccggcgg 98460
tactataagc gatgctagat gagcgtggtt ggcgcatgct gacgtttttg cgtctcgttt 98520
caatattatt ccgcctgtga tcatataaca tgccgttgcg atgagtacca gtccaaacga 98580
atagaaaaaa aataacacct caccttgctc aaaaaatagg gcgggtacaa ttcctcccat 98640
aattggattg gtgaatccgc cctctattgt cttattaaat gttgtataat ctacaacggc 98700
ggcaaaaaaa caagggaatc cggttgtctt gaatgacgcg gagatcagcg tgactgtata 98760
catcaacaag actaacacaa aacaggctac ttgcaagaac cataggcgta gatgaacgca 98820
atcaattcgc cccgcaggat ttaaacgata cggcccattc atggatccca ttgttaccga 98880
tggcgtcgat cccggttcct gttaccaaga tgatagaagg gcaacagatg accacacgtg 98940
cagtgcgtcc cttgctaaaa tgctgtatgg cggagacctt attgagtgga tttcgcgcta 99000
caggcccggc gttacctccg aagtgcaatc gacgggaccg gtatccttcc ccaagccaga 99060
tgataaaaga agccgtcgag tgacggtagt acgcgcgcct atgggttctg gtaagacaac 99120
tgcgctgata gaatggttac gagaaatact tcatagccca gacatcagcg ctctggtagt 99180
atcgtgcagg cgcagtttca ctcatacgtt agcaaggcga tttaacgacg ctggattggt 99240
cggttttgtc acgtatttta cgtctagtga ttacatcatg cgcggtaaga cgtttacccg 99300
tttgatagta cagatagaat ccctccgccg cgtggagctt tccctagtcg acaactatga 99360
cgttctcata ttagatgaag ttatgtccac attcgcgcaa ctgtattccc ctaccatgcg 99420
atatttacac caagtagacg aattaatgac acgcttaata cgccactgcc cgcgaattgt 99480
tgctatggat gcgacagtca atgcccaatt agtagagtta ttggctgatg ttaggggaga 99540
tagtaacgtt catgtaatcg tcggagaata tacctccgcc gggttcgcgg accgcgcatg 99600
catgattatg cgcgatatgg gggtagatac gctgcgcgct gcgctaaacc cgccttcgga 99660
aaccacagcg acgcaaaata tgcaaagcga aaacgacgat ttggacgccc agcaggtcca 99720
acagccacta agaccggata cgtttttcgc cgaattgggc agaagattat ctgggggtct 99780
taatatatgt attttttctt caacggtatc attctctgaa atcgttgcta aattctgcct 99840
taaatataca gactctatca tagtgttgaa ctctacaaga ccccagcaat cagatgttac 99900
gacatggaat caatatagag tactgatata cactactgta gtgactgtcg gactgagttt 99960
cgatgaatca catttccaca gcatgttcgc atacgtaaaa ccaatgatac atggtcctga 100020
tatggccact gtttatcaat ctctgggccg tattcgcctc ctacgattga acgaggtgtt 100080
gatgtatatt gacggctctg gtgcgcgctc ggacccaata tttacatcaa tgttactaaa 100140
tcatgttgtg gcgactggcg gtggatggcc tactaaattc tcccaagtaa ctaacctcct 100200
atgctgtaga tttcgtgata gatgtgcgcc tacgttttcc gaatcatcgc gcgatttatt 100260
tttgttttca cgtcttaagt acaaacactt ttttgaacga tgtactctca acagtcttaa 100320
cgatagtcta aatataatgt atgctctcct agaatccaat cgcatacgca ttaatcttgg 100380
agggcatgaa ccatcagcag atgaattttg tcgcctacta tcagacatac aacgcaactc 100440
cataacaact cagcgacaat tacgtgcatt gaaaaaacat ggaaatggac gcctaccacc 100500
ggcggtagag gttgccgaca gtgaagaggc ggccattttc tcagaaaaat atctccgacc 100560
agatgcatca atagtagata ctacagagct actcaaagca atggccagcc caattgtacg 100620
cgaacatttt gtcaacactg ttatgattga agcatgtcgt agaatacccg ccgcgatgtt 100680
aagcgaaacg gtttttagac gcttgtattg tcattacggt tctggcacag tacctaccat 100740
aacaaacgat ggaacgattg aaacggtagc tcttgtatgc gattttaatt ggccagccag 100800
atgggactta tatagactat gtgcaaagat ggcagatgcg attaaattag acctgcgcaa 100860
tggaggcgct accgtcgacc taaacttaga tattatatct gatacattgc gccctgatta 100920
tagcaactat attagattac tattggaagt ctcaagatgt aatattacag aatatgactt 100980
agttgcaccc cagccagtac gtgaggtaca agctgcgctg gccggaatgc ccaataacat 101040
caggcaagtg gggcctgatg tacatgcaat gttattattt aaagtaattt tatatgaaat 101100
gttaggtgca catctaatgc gtagtacgcg cagttttccc ggatcagtaa aggttaaaaa 101160
tcttaaaaag gaggaaattg tgacgttatt gacagaggcg ggtattgact tttctgactg 101220
ccgcacacat aaagatctgt acgcacgcct aatgagccac aaaaacaaat ttaaaggtac 101280
aagatatcgc attaaatcac ctaaatggac taaattattg cgcagtgcca gagatttgga 101340
caatgatgga tgggagccga gtctagaaac tgtattggct gacataccat cggaacattg 101400
gccgagggcc gagggagcag ttgattacag acaattataa tttgaggcct aaacactagg 101460
tatggaactg caacgcgatg gaggatttat aggcactaag gaacaattta ctagtattga 101520
tggatatatt tgctcgacct caatatatac tctgtggact cgcccaggaa gtaaaaatgt 101580
actgtccgta ctatcgtata tactattcag gaacattaaa aactctcgat acgaagccca 101640
ctttaccacg gttgatatta atctcaatgc aatggaagag accagcttgg cggaagaagc 101700
ggccctaaca acaacatggg caatgacggc atgtcgggat acttcacgac caggggcatg 101760
gcctatgtct agtatggcga acgtcggaaa ctggaaacgc cttagctgtt tggtatctgc 101820
gcatgtacgt acgaaattac gctatatgtc attttattcc cccgtgcgcc ttaaagtaga 101880
cagtaacact ggcctggtta tatataccga gccgataaac ttaacttcgg tacctatcga 101940
gcccaaagtt ggcattctaa cagccactgc ctgcttgcca attgataatg cagcagttgt 102000
agcccaaatt cgaagttctg ctggaccatc actggctaag gctaggatgg ccgcagcgtt 102060
caaacttgac atgaccaaat cacatcatcg tccaaatgac catatatatt cgttagaagt 102120
atctatctcc actaaaaacg ctaaatactc aagacgctat tccgatgatg tttatgcccc 102180
acctgccaaa agttcatgct caggggatag catgtttgag ataattgacc gtacgctttt 102240
tttggatggg cgcgaaataa gtatacgtgt gttgttgcct aacggatttg actgtctcgt 102300
cgcttgtgcc gacggatttt ctgcattgtc cgtgctggct gtatatagac actggcatga 102360
aacgatttac gatatgcgca aatcctgcgc gatcgttccg atctttgcat atgtgggacc 102420
tgaactttat ggccgcggtg aggaacacga ctactttttc accgtcggct tccctggctg 102480
gccaacgtta aaggccaagg cttctgaaga tggcatcaaa gaaacggtca gtacatatgt 102540
cgatttagat ggtctgtggc caatgtcagg cggcatggca ttgcacttat tggcaccatg 102600
ggcccctgaa aaacgaccag gtaatgattt cggaacagat gtcgtggacg ttctagctaa 102660
tgcaaagatg aatgctctgc gagaaaaatg gcctgccggt cgaatgacat gcgttctacc 102720
ccacgggaca tttatcgatg gtgctcatgt ggtccagatg gacttttctg cctttacgcc 102780
ctcgctatat ctgacattat atccatcgca taaacgactg gagcacgcgg ttagagcaag 102840
acataaacgc gaaaaaccat ggctaaagaa agcattagta gagttctgtg gcatgttgaa 102900
acatactcat ccagaagcac tcgatgcaac gatagcgatt tcaaatgcca taagtgaagc 102960
tatagaagaa actgctacgg caaatgggtt agctatctgt acctatataa aagatggatt 103020
ttggggggta ttacctaaag agaataatca gcgcccaaac gatgacattg tgaatatatg 103080
cgctctgtgt cagaaggcgg cggaaaacgt actacatgac ctacatctgt tgagacccac 103140
cggccccggt ataaaactaa gggtcgaaga ggggacatat acacatgcta tgtcgttggg 103200
tatgcatcat tactggttgg ggggcgtcga cagtgaagat tacaaactcg tcggctttcc 103260
aatacgtaac acatttagtg aaaacgtagc caaaacagta gcaacgttac taagttgcgt 103320
agccgctaac tccaactacc gtatacttta tcctcttttt aaagaggcat ttgatcgact 103380
aataacaacg gcctttgaaa atagaaacga cagtacattt tggagcgtag atgtaccgat 103440
atcggatgag ccaataccat caggtgcatt tagttacaat gatcatatgg atatggatca 103500
tgggaggaga cgtgtagttg aagtaaagac ttttagtgag cccgtaacca ttccatgttc 103560
attgctcccg ggaccaatga tagttcccgg aataatgtgc ctaaagtaca tacgaccggc 103620
attaaattct gcttgttcca tattatcgca cgccgtttca tctaaatggt gcaatgaaga 103680
tgtagaagcg tttacttatg atgttgaaca attcgaaccg ctatttgctt aactactaac 103740
tacctcacac taatatttga aataaaacgt ttgaagacac aaatgaataa attgtatttt 103800
ttatttgttt cataaacaac taagttagta tgtataataa agctgttctc ccgtaagctt 103860
ctttttctga ctgatccacc aatcatagat agcgtctctt atccactcac atttcagcgc 103920
ttcgttgagc actccgtcag ctatcacgat tgcatcagat gggcattttt gtacatccga 103980
tggtaaatca aacttcttcc cacccttggc cgtatatatg gctgcgagta cagcgggcgg 104040
ctcgtccaat atagacaatt gtcttattat tgcatgatta ggtagtacat gtttggggtc 104100
aaatggttca cgaccactta gcagcatgag cgtattcagt agccatgttg caccaatgca 104160
aagtagtctg cgcatctttg tcataaccgt tactgtagac catgccttcc taataaaagt 104220
atgcagttgt acaaataatg acgaacatat gcgctctctg ggacaattct ccaaaaacat 104280
aataaccaga cataacgcaa agtccaagtg ttcggaaggc ttaaatatag tcatacgatg 104340
cttcaaaatt attggcggga cagccaatgt ctgaacgcga tcttcggcag tcgtgataac 104400
agcaaatgca aaccctctaa atgcagtctg agcgagacat tgagtgtgat atacattact 104460
aggtacttcg atggaattag acgagcctgt cagttgcaaa tataactgtt gtaggttatt 104520
actatttacc ctcagactca tgactgaggc gcctgtaaac cgcgtaggga tgcctggtac 104580
ctctcgtact tcgcacatta gacgcggtat cgcctgccaa cttatatcgt cgacgagtgt 104640
cccgagcttt tcgttcccac tcgctgcgag cttgacgagc tcgtttaacg ttgcgctgtc 104700
ctccagagga tggtttgtcc cgtaattcat aatcttccga accgcttgag taccgccgtc 104760
catgatacat gcgctctggt tcatatccat cttccgcaaa tcctttgcgt tttacggaaa 104820
ccgcgccgct ttcgaacaat gcctcttcgc gtgcaatgtt cgatatcgca atttccctct 104880
tgacatcggc tacgaatagc gcgaagaggt ctgctaaata tgtttcgagg cgggtctttt 104940
ttaatattga aacacatagc tcctcctccg aacgatatgc ttcctgattt gttaccacaa 105000
accccaagcg ccgtacacgc aatacagaga aaaaatatgg tgcaacgagg agagttattg 105060
cgctattaga gtatgacagt gctacctctt gaccctgatt atttgtagta cgattcatct 105120
tgaaacaacg cactagttcc tgttcccaca aactagataa tcttcgcaat tcatctgcat 105180
aacttggtat gtaacgcgat tgaaaactgt tggcaacata tgcatcatcg cccatacgtc 105240
cactaagatc tattacctca tgtcccaaat ctctaatgaa tgttgtgatt gttccaggag 105300
tgtcagacat aaccggcaat cctcgcggca tagtttctat gccgccaatt tgtaaagaat 105360
taccagaaga attagtagct gagtctatag cagccattcg cgcctttgct aaattctctt 105420
cacttgtgcg caggcgtgag gccagttctc catttgtctc tttgagacct tcaattgttt 105480
taaatagatt atttacataa ctctctaaca gaccattaat actgttgatt acggaagttc 105540
taaatgcctc atgcacccta acggctcctg tagtttcaaa ctgtccactg gcatttgctt 105600
gatttccgcg accgaaagcc ttcccaaaac cggcctgaga cgtatctaca gacgtatcgt 105660
ctaacaaatg ccctgcagtt tcatctaaat acgctctaac tgtatcggta atatctccaa 105720
cgtgtctcat gccctttagg ttaataatta attttactag cctagacgcc gccgatccgg 105780
ccgcggcatc ttcttgagcg cctaaagctt tttcgactgc cttttgggca ccgacaattc 105840
cacgttcttc ttccggtttc ctaccaagta atacctttac tggagcagta tttaacaact 105900
gacatacccg agcatgttct ctcaaatcgt ggcacatcat cacttctcta tggaggcgct 105960
ggagaggaga atcaaatatt acagtaccat ccttccatag tggttgccac accaccatac 106020
actccccgcg ctggcctgtc acagaatcct tgacaaatac ctcacgtttt ttaaaattgt 106080
aaaagatgat ggccctatca taatcgagta ttgtaacggc atcgacttta tttgcaagtt 106140
cggctgctac ttgcctacca cgctctaata cgctatcagc aactaacaaa cgatcgcata 106200
gctctgtcgt taccacatta tccgaaccga catcttcatt caagcagccg gccgtatcgt 106260
gtaaatgccg tctaaaggaa cttgatttac agtgttcgtt tcttattagt ggtaccatac 106320
ccagacaaca tatccaatct atatatttag aaaagctggc ggtaccatcc ggttcggtgg 106380
acgaaaaaca cgcgtttacg ccacgaatca aatctataag ggctgtttgg agtgtttgtt 106440
tccaggtact aaatatctgt tcggctaccc gcacggcttc agcttcacta tattctccat 106500
atctcttagc tatatgtcgt gcatctaacc ccctagtttt tacatgcgtt tcccaatcgc 106560
ccctaagatc ttcataacgc acagcgtcta atgtgttggc tagtatagtc gcctggattt 106620
gtcgtatggc agcttcggtc gaccttaccg aattataaac tccctggcca tctgtatatc 106680
ccaattcgcc gagtaaaatt ttcttgaata aacaagttct ttccgtagga tgtatccgta 106740
cccaatcgca aattccatca catatatcat gcagcccaca ttgtaactta tctgttatca 106800
tgctttccga gtgttgttgc cttccgccgg tattgatacg tctttgtttg ctcctcccag 106860
taccccagtc gtgctgggcg ggacatatcc cgcattggtt agctgacata ttaatgctca 106920
aatcagcagt agattatgaa ccaaacaggt tacccttggt tcatcatatt catctgcgta 106980
aaaaaaagag aggctattat ggaaatgcaa ttaacgacac aatccgttga ttatccagag 107040
acggtatatt taaattttac ctctatgcat ggaatcagac caatagtaga tcgtattcgt 107100
tctatggcct cttcgcgcgt acctgctacg aaaatacctc cgctgtcttg gttccagaag 107160
gctttaacac tacaaacgcc gctggacttg gaactgagag aacttccgtt ctactcatac 107220
ctcatcagcg gtaacgccgg atctgggaaa agcacgtgca tacaaacgct taatgaaatt 107280
attgactgcg tcataaccgg gaccactcga gtagcatccc agaacgtcta cgcaaagctg 107340
tcggcggcat actcttcgcg ccatattaat acaattttcc aggaatttgg attccgcggt 107400
aaccatgtac aagcgcaact tggcaagtat caatattcat gtccatcaac accacctact 107460
atacaggagc tccaaaagag agatatagtt tattattggg acgtcctaat tgacatcact 107520
cgtaatattg ccgatggtgt agacagaaaa caggggggaa gtaccttcga ccttataaga 107580
tctattgaag acgctctatg ctatcctaga ggatcattag gagaccttgc ctattgtatt 107640
aatggatctt tgccatcgtt tacacgatct aacgtaatca tcattgatga agctggtctc 107700
ttgggtcgcc accttcttac tgccgtgata tactgttggt ggctcatcaa tgcctcatac 107760
ggtactcagc aatatatgga tggtaaggct ccagtcttag tttgtgtcgg ttcccctaca 107820
caaaccgcct ccctggaatc tacttttgaa cacgccaact tgaaatgcaa agtacggtca 107880
agtgaaaata tattgacttt ccttatatgc aatcgtacaa tgcgaactta tacgaatcta 107940
cctaataact ggtcaatatt cataaacaac aaacgctgtc gcgaacaggc atttggagat 108000
ttgctaaagg ttttagaata tggtctacct attacggaag agcatgcgcg cctagtagat 108060
aattttgtag tgccggaggc ttacatcaac aaccctgcaa atttgcctgg ctggactagg 108120
ttatattcct cccatcgcga agtcagcgct tatatgacgc gcttacatgc acaccttaaa 108180
gtatccgggg aagacaaatt cgttgttttc acactgccat catatacgtt cgttaacatc 108240
gaaaacttcg aaacataccg caaaactgcc aatcagccaa atctatcagt tgagcgctgg 108300
ataacagcca atgctggaag attgagtaat tggtctcaaa gtcgcgatca agatactagc 108360
caacttagat gtgaggtgta tcgtgacaaa ggattaatac tcgttagttc tgatataact 108420
tttgtcatga acagtcaagt agcagtaacc acccgactaa agagatggat atttgggttt 108480
aatggtacat ttgaatcatt ctggaacgta cttaaagatg atatgtttac aaaaacgcaa 108540
ggagaaacat ccatagagta tgcacataga tttctgtcat cattgatgta tagtggactt 108600
atcaattttt ataactttct acaacagaga ggcttaaaga cagactctgt cacaacggca 108660
tacagacgca tggccgagct tactaccact actatcggta gtacgtgtac cgagacatcc 108720
cagacgggcg ctggcaatac caacgcattc gatcatgaga tgtatcgttt tgatgactcc 108780
gcggcgcaac aaaaacaatc tactgcagat gatgatgtag tgttcggagc attgtgcgat 108840
gatatgatcg acatgctata ctgcaactat gatttccgtc ggccagaaac aacggctgag 108900
gtgtatgcac agtttgcaat actcaagaca cttttcatgg gccgatatgc cattttgaaa 108960
gagttatttg gccaacaatt ttgcaaatcc aatttctgta catacgtaaa taatgttaac 109020
ttccgcggct gtgaaatgtt tacttcgtct ctccgcggag gtatgatgtc catggctcta 109080
cagacagaca cctatacatt ggctggttac acacgcgtaa ctattcaagc attcacggac 109140
gatcctatac gtcgttatgt aagcgatcaa actaacgagc tgttacatga aattggcatg 109200
ccgttaatgg tattgcaaga tcaccaagga tttatgtccg tactgaacct gaacatatgc 109260
gattttgtag accccgttgg agataaggat ctaaatatgg ccactgtggt agattatggc 109320
ctcagttcta aattggccat gactatagcg cgctcacagg gtcttggcct agaaaaagtt 109380
gctatctgtt tttcaaagaa tggacttaga cttaatagtg tgtacgttgc aatgtctagg 109440
gtagtaacgt ctgaattttt aagaatgaac ataaatccac tacgagaaga atgtacaaga 109500
gaagatgata tcagcgaaca tatactcgca gcattgagag acccaaacgt gcacatagtt 109560
tattgacgaa ttataagaac tgctggtacc ttgcccacgc tcgcgcccat tatacatgcg 109620
atcgcatatg caagatatca tcaggtctta taactatacc tctggtagtg cgcatcagtg 109680
tattgtgtct gctgtcttgt cgtttccttt taataaatta ctgatggaat atggcgcgcc 109740
gacgttcatc cgttggtgtt tagcgttatc cgcccactgt gtaaacatca acggacaaaa 109800
cccggcgcga catccgcacc tgctcatcga cgtggcgcca gcattcacag acggccatgc 109860
aatcgcatcc ggcaacgttt ataacttaca ctctgggggg taccggtgct tcgcatacgt 109920
ggactgttcc agaatatgaa caagtgatct gttcgtgtga tggaggatcg agatctgttc 109980
tggtcgggaa caagacacgc tgtgacaaac tccctccgtg taatgttatt attcaacgcg 110040
gccctcttgg gactctattc gtcgtagata ttgggtatgc aatatattcc tatatgctac 110100
gttgtgatct aaaacaacag gtcggtacat tatcagcctc acctggttca ttatatgtag 110160
ttccgtttac atcatgtacc gtagtcggag tagatagcta catccgcagt gactctagtg 110220
gtgtattaac gattgcatgg tctcataata cagtgcatat aacaataact gtatatggtc 110280
tgtcggaaga gtctcagcgc atggcaagcg tttcggccat atctactgtc gggcaagact 110340
atgaaaatct tcaggatata gccaaccaag agcaaagtga agatttacta tctgctgcaa 110400
taaaagaagc taatattggt gtcgactaca tatcagatag tgagtcgtca tctagaacgg 110460
ttatggacga cttactaact tctattcaag atgaatgcct agagacggcc gactgcttct 110520
gcaatggaac gtctcaggag ccaattgcag tgaacggtat agacatttaa cctttaggtc 110580
tgtattttat ttccccctcc cccgaggacg taaataaata aaacagtaca caaaagattt 110640
ttatattgtt tgtttattat tttgtgaata ctcccattta cccactaaga ttctaaacgc 110700
gattgctggt ctatgagtcg ataacggcgg tgttgatgat tacctggttc aggccgctcg 110760
tttccgccga gtgatccatt aatgagaatg aaccttatga tctttcaaag gaattgacgg 110820
cagtccatct ttttgtttag cgtagttttt acttcgcccg ttaatgcaaa gctctccaac 110880
agtaaacccg cttcgtctgc gttgtctctt agaggcgtca atagagacgg gatgagacgg 110940
cgccggttct gaaccgcgac gtctgcgctc gcaactttcg aaccctaccc ctgatgcttt 111000
ttcccaacca ccacatagcg caaaatcacc tgtccgctga cgtctgctgg cggacttgtg 111060
tagtttgcgt gcagcttgag gcatggcaga cacaaaacgc ctaaagtcat cactagatgc 111120
taatgccgcg cgcccgaaca tagttcgcga tcacttcagg actgaggcgt actgacctct 111180
attacgttgt cgcgatgtaa aaagacagga tctacggcag caaactcgta tacatagact 111240
ggaactacgg gttgggtacg gccgtctgca gaacgcgtat agtacttcct cggcttccta 111300
gcctgaataa cagtctgtaa ccgatcgcgt atatacttcg cgtgtactct gcgacacaac 111360
acaaacatct gcaggctttt attgccgtgg ccacccttta ctgtttgtct tgacttactc 111420
cgcctgttag aggatgacga aaacgacgaa gtcttagtac atgctattgt aaatttggct 111480
aaagaatgtc gcaagtcctt gcgaatggta tcggtgagaa ggcgtctccc gagctcgtca 111540
atcgacgaaa ccataaacat agtatcaaaa cttacatagt tttgatcaca tgttgtttca 111600
ttcggggacg taccgcaccg tcctcgttcg tcgtaagtac ccgcaggtgc cccattctgt 111660
atattaacat cagatgttag cacttccgcg cccggaccgc ggtcgcgttg gcaatcaaac 111720
ttacttctac tctgttgccc gttcgccgct cccatagacc acccactgca taatgttccc 111780
ctttgatcga tgcgtgtgca atcacgttgc gttgtactac attcccaacc ccaatcacca 111840
agtaccgtta taatagatgg tactggggtg tccatagtcg aggactaagt ccaaccagac 111900
gggtgagtcg cgtgcccttt ttataaaggt gtaagttaca tccgtaacgt cgtttatact 111960
gttccacaag gaagttgcca gtcaaccggc tcaacgccac gaccttccag gtattcattg 112020
gcctttttaa aatgatcaca taagatgaat ggctttctag acagcggtga tggatggcta 112080
tatttcaaaa cacaatgctt gcgacaattc ggtttgaacg cttcctgagc atgcacgccc 112140
cacagcataa acactaatcc ttccttattg tcatgtaacc attgtaatac agatttgact 112200
atttttgacc aaccaacgtc tacatgcgat cccggatgcc cctttcgtac tgtgagggtg 112260
gtatttaaca acaaaactcc agctttggcc catgcctcta ggcagccatg atcaacaatt 112320
ttcgtctctg ggtaagagcg ccgaacggcc gataatatat tacgtaggct aggaggtatc 112380
tgaatacctc tccgcacgct gaatgcgagc ccgtgagcct ggccgggttg atgatatgga 112440
tcttgcccaa ctatgatgac ttttacatcc gatggagcac agtacctcgt ccatgtaaat 112500
atttcatttt ttggcggcag gacttcttcg atgtcacagc gccgttcata ctcaagtaat 112560
actcgagacc ccacttccga ttgtagctct tggtataata cttcccgcca agcatcgcca 112620
atacaataat cgccgctcaa tttttcccac tcggtgggac tattaaacca cgaaggcgcg 112680
acctcaccgc gaccgctgct gttcgacgtc tgaggttgtt gtgctatacc gcccccctcc 112740
ctcatacagg caacgaaacc cgctggcgca ccacaaggcc tgcgtcgttt cggcgcctgg 112800
gacggagacg ggagcctatc gtcggccatg gtgtccgggt tcacttttgt catgtcttcg 112860
gccatatctc gagtctggat cgaatgcata acggatgctg gcctgagggt ctttgaagcg 112920
atgcatattc gcgtttccgt ggcaggttct gtcatttggg tctccctcgt tgacacagcc 112980
agtacctaca ggcgcagtac taaagctcgg cttcccgccc cacgctgaat ttaaggcttt 113040
ctgaaaagcc ttgaccccca cgtcatcacc tattgcaact tcagagtcca gcaaaaaccc 113100
agaaatcgca aggttagggt tgacccataa tgcccgctgt ggacgctcat accacaaaac 113160
tacctcaatt tggggacagt gactgcggat aaatactcca gacaacaact ccgtgctctt 113220
tggtggtaca gctgcatagg ttgaagtctc cgaggtccct gggcggaggc agtccctaga 113280
tagtatagac aggacatctg gagcatacat aactccttcg ataaccgggt aactacagga 113340
agtttcttca aaaaaaccca ttacgactag gatcacgagc gccaatctat gtaaagtcca 113400
acccattgtc ccgcaccaca agttcggaac gtttcgttct tcggccaccg gacgcactac 113460
gtgtataaca cgatgccgta ttatacctac aagtgttttc aagacggcct tccatctgga 113520
acccattatc gcagttgtag actagcccgt gcctatgtag ggtcgctggg agtagtggcc 113580
tcttgcgcga acaggcccca atacttcccc gtttggagaa tggcgacctt taaagggagc 113640
aaagtcttgc gacgtacgcg cgccacgaca tacgtatgtg caatataaat aacaaagacc 113700
agttaatgtg tgttaagaac ttttattaac caattggcaa tcgaaacata ggatttgtaa 113760
tatgaacaat gtcaggttta cagatcacgg gccaattttt actagaagcg catgtgcgat 113820
gttgtaaaga gtttacaaat tggaccaaat taacggttag gcatgtcgtt acaaaattat 113880
ttctgataca ttgttagctc gttaaagcgg tctggtggtt gtttagtcta atgtaactct 113940
cctacaaatt acccgacacg cacctacaat ttacacctcg gcgacaacat caacattact 114000
aaccccctct tttatgtcct aggtcgcctg ttacccatat tattgtcgcc taatgcggtt 114060
cggtatctga accccagatg gtctatttgt gttatgacga ggggtctggt ggcctcgaag 114120
gcgagcggtc ggaacgacct gatcgtcaac cgttcgcctt cgttgcaccg gtacctgctc 114180
gtggttaact ggtgagcgtc ttctccgcga accaagagaa gttgtagtac tacgatctac 114240
acgacgccta tatgccggtt cgtcatcgcg atcagaaaat tcatcatcag attcattact 114300
atacaacacg gcacgcgcgg ccgcgagagc agcttgtgta cgtgttatga gctctgcccg 114360
tctggctgac gcgcgtgtat acaggacttc atcatttgca ccatcgtgtt catgttcttg 114420
agctacatta cttccagatg gttgttcatc aaaactatcc gagtctaaca gatacacgtt 114480
ccccgtaacg ccctgttcgc catcatccat tctatcttcc tccccaacat ccgcatctat 114540
attgttatct tcctccccaa catccgcatc tatattgtta tcttcttccc catgcccccc 114600
ctggtcttca gctatataag cattatcact gttttcctcc ccaaccgatt ccctgtttct 114660
gttgcccgtt tccctattct catcccgtcc gattcctaaa aggacatcaa ggcttacaaa 114720
ctcttcatca tcgtcatcaa catcttcttc tgatgacgat gatggaacta aaatatcatc 114780
caaatcaagg ctctcttgtt cctcgaatgg cggtagatcg agaatgaatg gtggtatatc 114840
gcccttaatg tattctgtgt acttctgcaa aggcgccacc gttgctgtta cttttccgtt 114900
acagattttg ggtgaagaac ctggggttag tccattaatt acccgctcgt ttgtcaaaat 114960
acatggagcc tctgtatatg ccatcagggg tacacacata cgacgcgcta aagtgtctcc 115020
tgcaacggta aaataaagtt caccaacgcg cggcgcccca taagcacaat gcgtatcatg 115080
tgggaggtga aacatacaac accaatctaa acacctgcgc attactttcc aaaaagccca 115140
agcttccgaa cccgccatta ctgattcaat aacatttcga agccaagttc tattttctct 115200
ataaagttgt ttcagttgtt catgttcgct aaattgcggg tatgccataa taaaccgcat 115260
agctgtggcc catgttgtag caagcctctc tatcataatc ttatcaacat taccatgaaa 115320
cacggcttcc atagccaacc ccctacaggc catatatgcc ccgtctatag cagcaataga 115380
aatcgcatct gcatcatgct ctgatccccc tatatgcgca cgttcgtgca tcatcactac 115440
acgcatagct gtgcgtagtt cgtctggctt cttggttagg ccgtcctctg tccgaaggcc 115500
cttgatgata tccagcgtag ttggaaaaag acctgtttgt caagagaacc acataagcct 115560
cgagtaaaac ttaatggccg atttctatgt tattgtcaga cagagggcta gccaggccca 115620
tgattaggaa aggccataga tagagaagtt agtaaagcca gaacgagatt tgtgatcgta 115680
gtaaagttca tgcaaagtag gtggataggc aaaagctatt atacgataat tagcccccat 115740
cttatttact cacgggatac gatttgctgc ataaatctta gcctatagtc tgggacactt 115800
tcaggcaatt tcagcccatc tgggtctctt gcatgaagtt ttggagcctc ccgcaacgcc 115860
attcgtaaca acgatcgacg agtgtcagaa cctggccaac tagtcttaag tttactttag 115920
aagaaccttc tgtaacttac acacggaccc gcctcgagca ttatggcaga ctaaacaagt 115980
tacccaatat tttactaaac aaaaatggga ggtaacagga agagtagcct catttgaata 116040
acaaccaatg ttagaatttc ataaaaatga aagcaaaata cgccgaaacg gcgccattgg 116100
ggccagcgga ggggatggtg agtttgaata aaaccacaat cccccctcac cgatcccaaa 116160
ggcaccgctc tttcatcgtt cgaaagtcat taacacaaac tagtaagaat atatagtaga 116220
tataccaata ccgcggccta tttagcaatg ctataaatta ttattatact tattggttct 116280
tttcataaaa ttgttattca taccatattg gctaatacgt acttaaacgt tttgttaccg 116340
agcgcccata aaaaagaaaa tgctcattat ttacgtgtct ccgccgacac cgggggcaca 116400
tcatcttggt ctctttcaca cctaatttaa ttagctggac tagctccgcc gctactgttg 116460
gttgtcattt cgtcggccct gttgatcaat aacaattaga tcccgctaat tgaacattag 116520
acccacgaac cgaaaaaagc ggcgggggtc aaatcttctc atattttgcc caattaatta 116580
attatcacca atataaagct attatatatt acagttaaca ctacacaata tatcgctata 116640
gtctatgtca ctattaaccc tccaatcatt aatatatttg cgacttactt tatcgcccgt 116700
caaccggtcc ccggacaccc gcgccttaaa caactagaat acaatttgtt actcaccagt 116760
gcatgcacat gcaccccccc ctcacaaata aaacgaacag actttgaacg actcgttccg 116820
cgcaaattta acccagaata cgatcttact ttcactttag aaaacggtcg gttcctatgt 116880
aacagattgt cgctggtgtc catacataca ttttttattc tcccgcaggc ccctaaacaa 116940
tccccaatat accggagatc tatttagccg gttcatttcg aaccgcaata tcgccggccc 117000
gcaatactgc cctttgcagc tatcccctaa ggtaagcatc cccacccaat aaaattagtc 117060
ccctttaaat actatgtcgg caagcctcct taacgccgcg gcggtaagaa tgacaactga 117120
gcggcgcggc gtcgctcccc ccttttatag tctgaggttg cgcaagctca gtgttaaaca 117180
gtggcgcccg acattttgtc atgagcatgc gcagaattac atagtgaggg aaacaagtga 117240
cgtatagaac gaccgccgcc catagttatg actttgcatt ttgaatctca gcgcagcggc 117300
actgtaaaac cgtttttaaa cggcatgggg ccatatagct ccattttata ttcaacacta 117360
gcctccggaa tgaatactga tgcagtacgg tcatgcgctg cggtgcggta cgtttgttta 117420
gtaatgtata tatttgtgta tagacgctaa caatggccgc ggctgtttgg acagtatatc 117480
ccatattgcc atgcgtttgc cgcaacttct acgccagcgt atgtttaaat ggcgcgatcg 117540
gagggaaggg gggggttaat ccaagcggag tgagataaaa aaggacgcta tgtttggaaa 117600
ttaactcttt gtttattgct ttatatgaac aattagtgtt ctgttactac cgtataggct 117660
tgtccagcac tgttacattt gcctcggttg ttccaaagtc tgcttttaga tatatagtgt 117720
aatttccact atttcggaat aataagcgaa gcatcggtgt tgttctgtca aaagccataa 117780
ctatcccgcg atctctggaa atgttgcaaa tatcccaaaa cgttaaaata gtatctgtct 117840
gtcctgtaac cgtgttgacc atctctattt gcataacctg tccgtgatgc ccaggataaa 117900
tagtaactga gctatttact tgtgttgata ctggaggtct gactgtcgtt aatgtaatgt 117960
tagataaatc gtcatattga aggcaacctt gtagcggcgg tacaggtata gtttctgtta 118020
cagtgagttg agatctgtat ataggtatat agtgttccgt ccccgcagat tcacatttaa 118080
aaatggatcc ggcatgtttg ccaaattcat gacaattata cagtgtcagc tttctagttg 118140
tcattggtag cttgtgtata aatgtaccat tttggtattc ccgcaggtat ccgcgaccgc 118200
cggaaagatg aacggataaa atcctgccgc cggaacaaga aatgaataga ggttttttgg 118260
tatcgtatga accatgcatt aaagcagccg cgacagaaaa agagcctaat gtatatgagt 118320
atacacccgt agagtacata acattaatta tcgaaccact tgtagccatt actactacaa 118380
gattggatgt agtaatatct gtactatgca tttcatatat ataccattct ggtctgtatc 118440
cataatatga aatgtaccta taatctaaac cagacacata agcattccat acagagtata 118500
caagaccgta ttgtccctcc ggagacctgt cgtccggctg caaggtcacc agactttgtt 118560
caacatccaa taacttcata tattgagccg ggccgacaaa ttgcgaacag agcagagatt 118620
ctgttggcgg gcccagtcgc ctaagtattt cttcatgtgt taatgtttca caaaagcgct 118680
cattaaaaaa attagtacca catattctcc gattccattt acgtgtagca gcatcacatt 118740
tacgccctcg tggtccacca agctttgcta ctatatattc atggccagtc agtagtttac 118800
ctggcctaaa aaagtcttgg ttagacgcga ataccactac atattctgca tcctgtttag 118860
aaattgtatt aattttagat gatgtaactc gcgattgtat ctgttgtata gtcagttcag 118920
tggatggatc aatcgcaact aaccgtttac attttgcccc agttgttgag ctaaagtcgc 118980
gacatatcgc cgaacataaa taaccaccaa tactatggcc tatacaatga agctttgtct 119040
gttctacatc tagatttaga aagagaaaac tcaactcgtc tatcattgca tccgcaatac 119100
gatcatcaaa gctgcttctg tttctactct cggttgtcca attaatgaac aagaccgtaa 119160
gtgttggtgt catacgttga tggaagcgca agaatgacat gaaaacattg tctgcgaatt 119220
taactccagt ccatccatgt gtcaaaagta ttatatcccg cccaggtcct agaacaccgt 119280
ctgttataag tgtgttatat atcgggtcca atagtgtaat ttatatatgt ttctgtagtg 119340
atattccagt aatgtagtgt agcggaacct gccgcctccg gcatgtattg gttctgtagt 119400
gttgaaacct tgtgttgagt agccttgagc gattccccat cccctaccac acgtggtcgt 119460
tgtttagctg taacggtcct ggtctgtttc cttttacttt ctttcacttt gggatcttct 119520
gttttcatat tagccatgga tgtgatagtt gtaattggtt gttgctcact cgaggcgtat 119580
tgtctaatgg gggcgacggt tgtcggttct tttccctgaa gttggctttg tctttcgtcg 119640
gtagactctg gtccatgtcc tattatgcga tctaaaacct aagtaaatag aatgggggtt 119700
gtagtaaatc tctcgcgact ctaaataatg gcaattgttt tctgttctta aagcagatta 119760
cttaccaaga agaatccaaa tattatggcg atgataatca gcactacaat gccgaagaat 119820
atcttacacc ccagtgaaac ctcttggcgt gttgctcgcc tcttttggcg gacgaagaca 119880
acatcgaaac gtgttccggc cgcaccattt ctttcacaac actattcctt agcgttctac 119940
actttctgag gtaacatcaa ccatatcaac accgcgtctt tataaatgtt tccctacaaa 120000
ctcctcccat gtgatgttaa gtcaacaaag gtttaacatg ctcattggca gtatttatgt 120060
gtgtatacat tgacacagat gcttatgtat ttatcagacc atgggaacat ttaacacccc 120120
ctgtatgata caaactccat cacggggtgt tagatgaacc caatggtatg atgtttgcaa 120180
ctagcgcgcc atatttatag caccaatatg caactagtgc accatattta tagcaccaat 120240
attagtatag actatatctt tataatatgt catgtagatg gtttagtacg tgcgcggccg 120300
cggccgggag aggcgttgga ccccctttgc catttcccgg gccatcgaaa aaagggggcg 120360
gggctttttt ggcggggggc caaaaggggc gtggcttggc aacatgccaa ctccacccac 120420
tgggcggggc ttgggctgat gccaaccccg cccacaataa gcccctccct tgggaggagc 120480
ttggatcatt gccaaccccg cccatgggag gagttagggt tggcagggtt ccaaaggttt 120540
tacggtatta gggttagggt tggccgggct ccaaaggcag aactgtctta gggttagggt 120600
tggcagggtt ccaaaggttt tacggtatta gggttagggt tggcagggtt ccaaaggttt 120660
tacggtatta gggttagggt tggcagggtt ccaaaggttt tacggtatta gggttagggt 120720
tggcagggtt ccaaaggttt tacggtatta gggttagggt tggcagggtt ccaaaggcag 120780
aactgtctta gggttagggc tggccttaag ccaagtaatg ttattggata gtgttggccc 120840
taagccaagt agggttggca aggttccaaa ggcagaactg tcttagggtt agggctggcc 120900
ttaagccaag taatgttatt ggatagggtt ggggagacgg gactccgaag gtagttcgct 120960
cttaggattg gccccatggc aagcggggcg ggtcttcatc cgagaactcg gcaaaggatt 121020
ggcaatacac caaataggcg gcgactgcat ctgatttagg gttggcattc gcccaagtag 121080
gaaatattga gccgaggcgc taatagggct agggttggcc atacgccgag tagatggtga 121140
ctgtagccag attctacctg gcctttatcc aagtaggtac tactgagccg ggtagcatag 121200
ttattaggac tgggggcgtt gggaggagtt ggagctaacc ctaatccaat tagatgcctg 121260
taatggcgtt atctttatca gagctctgtt atcactttat tttacctccc tctttttgcg 121320
tcaattgcag cctatgtgtg ttaaggaatt aggacctgtg gattactatc atgaatgtcg 121380
gccagcctct ccgcttggta caaacgaaat ataaagcggt agttgcccga cagccatgat 121440
agtctcccat gaacttcggc ggtttagtga tctttgtaac taatattcct ttacggactt 121500
acatagtatt tagacttttg acacttattg ggatggggtg gatggtttgg agacagctgc 121560
ggtggtctat acatctaata accatccatg caatctccaa acaacctacc aattccacca 121620
ataacttttt ggcccggcca tattcccgcc cgtcactttt aaataagaac tacaagacag 121680
attgcattta ttaaaaagac tttattctta actatcgagc tgaatatgtc gaagacctct 121740
atttctttaa aaactggata catagcgaag ctattttctg tgtataaaag gctgtctaaa 121800
aaaatggaga atatataata cggtgcaggt aaaaaaaatc tcttaacaaa aaatcagaaa 121860
aagtcacgac aagctcccgc gtacggattg ccctcatccc ccgaatcatc cccatcggac 121920
aagatctcaa tttttatctt atgtggtgct ttgggcattg gagttataga tggctgtacg 121980
gcagtaattg taacatcatc ctcattagat tgttcattgg gcgggataat agcctgcttc 122040
atatctccgg cctcgatgct agtagcccta gaccccccgt gacatagttc ccaggttatt 122100
gtaggtggac gttggccgcg ctggatagta tttggattga ccacacatac attaccctcc 122160
atttgcggtt cgagtaaagc agctgcacag tatgagcgga ctacttctgg aatgtcatct 122220
ggggtctcaa aaggatgctt ccggctctct gtcaggtaca aaggcctcag aggtgctcct 122280
agaccccatc tatttgctgc cctatgatta taagcagccc cttctagaaa atctggtccg 122340
cttatactga gtccatctgc ctggaaggcc atatccttgc ggtcgtattg cggaagaaca 122400
aggccgcgat attcacgggg ggtcattggc acgcgagtag tgcgaccggc ctttgtctcg 122460
acaacatatt taacattatc acctctcatc agctgtaatg ggggttcatt agggtatagc 122520
tgagcgaacg cggcttcgac ccgcgcaaag actccaggcc ccactatccc acgtgatgtc 122580
atcactaccc ttgacatggc ttcacaatct ggccatctgt gggccccatg ggcctgggga 122640
gttatagtcg cctttatata tgaatgatag ctactaattg ctggaccgtc ggcgggccaa 122700
tccactgtat caattgtatc caggaaaatg agccgcttgt gggccgagcc gagcctgagg 122760
catagatatt caaccgcccc cgcaaatcct aaatctctaa cggatagcag cagcacgccc 122820
ctggaattga gtgcagaaat atctgggacc ccagtccagt tacccgccca tgcgtgactg 122880
ccgtatgaac aaaggcggtc acacaaggcg gctagcagga aggagaggcc acctttttca 122940
tcagaccaca taggcatgca agaggccact ggggcggcgc ttaattcctc ccctacgagc 123000
gggcagtaca tgatgaccac ctttacatcc tcagggtctg gaatctggtt catccaagca 123060
cattgtttgc ggagcggatc agtgactcgc aggggcccgt atagtcttcc ttcgacatgg 123120
cttccgccac gtcgtgccgc cacgcgggcc agtgcctccg gatcaaacat taaagcgggt 123180
ttccagttag gaggaaacat agggtcatct aataattctg cgactatgtc gggctggcaa 123240
taggtagacc gtgccgactc ggttggcagc ggagtatgtg ttattccggt ggggacgcgc 123300
ctatatcccc cgcggggatg gggcccgcct tgcggcattg gaccgagagc cttgaccgac 123360
ggcagtgtcc gcggtaaccc ggtttggtta tcctttttag aattttgtat attctgatgt 123420
tttggcaagc catctggtct atctcggtcc tttggggcag tatcatcact taacacccag 123480
gatagtttgg cgccattgat cttggctgac ccatttccgc tcggggcaga aaagagcgcc 123540
tctgttaggt tccatgcaga atatctacgc ctagccctgt ccacggaaaa gtttacaaag 123600
ggtctcacag tgctaatcac cgtaccaaca gcacgaagcg ccataacaca tgattcaatg 123660
ccctgcgacg atgaaagctc gccccgtagt ctcatagcat ttatacatat aggcaacagt 123720
ttaaggtcct ttatccatga tagaagctgg acgtgatgcc ggtggagctg ggcagacgga 123780
caggcagcgt ccagctccag tgaggaaata ccaggaatgt tgccggcacc accaaagcac 123840
tcgagcaata cctctattac tgcattacaa gctaaaacgc acgcatctgc cagttcctcg 123900
gttgagtaat cagatgcatg ttcgggatca caaaagtcgg ggtccgccgc gctctgctct 123960
gtcgccagat ggtccgtgga ctgcggtgtg ttctgcggct ctatctgcga gtcgccgcga 124020
accgtcacag tctgcagacc ctcggtagct tcgcgcatgc tgcggcggac agcattcatt 124080
cggcgataaa tggaagaaat gtcatccgtt agagatgcgg aggcatcaac ggcctttgcg 124140
gggaaaagca tgtaagcata cgccctccgc agagacattt gcagaaattg tttttgcact 124200
ttatcatagc ggcggctcat cgctacggcc gcggcaacat gcggtagacc ccatagagca 124260
tttccagccg ccatcgcatc tccaatatgt ggtagaggtc gcgcaacact tccagtaata 124320
aatgacccgg aaccagtacc acccctcaga ttgcatcgtt tttgacaaac ttgctccaat 124380
aacagatcct caccagttat tttgttacat tgtatccagc ccatagcatc gaaactattg 124440
ctatatagtg cttttacaag agcatcatac tgctttgatg aatcccccat ctctcccaca 124500
aaaacagcca ccggaccgcg gctctcggca taccgctctc tggcataccg tatctctggt 124560
tcatcccaca gcccctggcg atagtcccca gtaccgccat accgcacctt gccaggtggc 124620
ggtggctcag acccgggcca tggatcccca tttgtcatta gcaaaggtcc gttcatagta 124680
ggcatttctg ggacgcctat tgacatacaa gactcagctc cggcgctaga tgatgacact 124740
cttttcatcg ccgatggccg tctcccccta cccctacggg ggcgctggta aaatgcgtta 124800
tttgacgctg gaggaggttc gcaggagact aaatctatgg tgtcatctga tgatgggtgt 124860
tgatattgag tggactcgcg agggctattc gcgagcatag ttggttgttc catagtctgg 124920
ggctgctgtt cggtttcttc ttgctgaact gcgcggcgta cgggttgctt gcccttgcgc 124980
tcggcggtgc ccgtggcctt gcttgcagcg gtgttactgg tcggtgggtg tgttaattgc 125040
tgcgaaaaca gttttgataa atcagtcttt ggggaccgct gctccgcatt atccttttta 125100
cgctgcatgg cgggcctacg cttctttggt gcagatggaa taaatgatgg aggggggcgc 125160
tttggtgttg gagggcggtc tggggatggt cccctagaaa cagagctccc gtccgaggag 125220
gaggaggacg acgatgtgga tgagctggaa ctggacctgg accgcccccg atcgacagat 125280
ctgcgcggcg acgcggctgg cgagcaacat gagactatag gtagcgcggg cggcgagcgg 125340
cccctggggg cagaccttgg cgatgtagac ggggggccgg aacgttccac gacaccagtt 125400
tgaggcgatc gcgccggcga cctataccaa ccggccgagg taacagaggt cggtgatgac 125460
ttgggtgtca tggtgcgcca actgtcggca catctagcag ggggtggcga tgccgatgaa 125520
gatggtgagc gatggcgcct ccgagcggta ttcttgggcg gtgctgctgt cggtgaccgg 125580
gcaggtgaag cgatcggttt atcaggagcc gatggtcgcc ccgcggtggc agatcttggt 125640
tttttaacac ccactgctgc ccccccgtta tcgctacatt cttcttcaga ttcaccaata 125700
tcaataacat cagcaatgcc cgcataattc ttaccaccgg ccgccacctt cgttttattc 125760
acaccgggtt ttttagccat tgttttcccc ccgcgaccca atttgtactc actctttctc 125820
ttcttttgca gatcggaccc ggtttttgga ccgccttcgg cgcgcacaac acctttgggt 125880
gttgtgtccc ctttctgccg catcccctgt gatggagatt gcattttagg tggtgtggcc 125940
tcttttatgg ggtttaaatt gccacaggtg gttggttctt catcactcga atcaatttct 126000
gtagggccgg gattaggttg caggggttta gtaaatgcag cgtcggaaag cggcggtccc 126060
atataatcca aataaagtcg cccatctcct ctattaaccg tttccatggg tttggtagtt 126120
gctgccattg ccgcagcatt cattacatta tctataagac acctcgagtc gtccagtaag 126180
tactgcgact cgtcaatcaa cggtgtattg ggcccctgga tgccgtgctg aatatcaatc 126240
gaagaaatgt tgctcataaa actacaatcc gcactcgcgg cggcctcaat caggtcagta 126300
aaatctgggt actgcgtctt ggccatgagt agagctgggc gtctattaaa aaagcataaa 126360
gtgacaccag ataagaactg tgcctatttt acaaaataat aaatctggaa gcggataata 126420
tctatacatt agtttaatta atatgttaac cgctattaca gttaattaat aggactataa 126480
gtgatcaatt acttgtagta attgagatta agatattaag attctaaata cctcaaaggc 126540
caaatcatgg atcaaattgt agtatcactt atcaaataaa aaatagttgt aatatttgca 126600
aagaaactta cttttagtct ttagcaatat gtcccagatg ctactccgag ccgtagaact 126660
gcagagagaa ggctgaagag cgctggttag accggagttg aagataggtt gatcgtagta 126720
gaactatgca acgatcgaaa aggcttctac ttaaatgcta ctatagaaag ggcgtagtct 126780
ttagccgcgc ccatacagga aaattaacga tgccttctta gttcgaggga aaaatgaata 126840
catttgccca actacaaatc gcggcccaca tagttgcatt ctattaactg tccgccaacc 126900
aagaagttgg agaagttccg caaagactca atttgcatgt tcagtagcat acgattaagt 126960
tttttccaat gataatgttt cacacagttc ctgttgtgca tattattatt gtgtattatg 127020
ggtaagttta cctaaggtgg ggtaaatgtt agcatatagt taaacaatca ccgataacat 127080
tattactatt cgtttcctga tacgaatata attaaagccc gctccaataa tgttattctt 127140
actatttcct gaatgaatac tattatcggt ggttatgggt aagttttctt agggcgggta 127200
aatgttagca tataattaaa ccataatcca ataatgttat tcttactatt tcctgaatga 127260
atactattat cggtggttat gggtaagttt tcttagggcg ggtaaatgtt agcatataat 127320
taaaccataa tccaataatg ttattcttac tatttcctga atgaatacta ttatcggtgg 127380
ttatgggtaa gttttcttag ggcgggtaaa tgttagcata taattaaacc ataatccaat 127440
aatgttattc ttactatttc ctgaatgaat actattatcg gtggttatgg gtagatgttt 127500
gcgtataatt aagcaacaac caataataat atttctaaaa catcctgcag tgcatatcat 127560
tatttctaag cctatgatca ggcagcatta ttcccgacac ttatatacct agccatgtgg 127620
tggcgctctc acgagaagtt atgctagctg gcggtcatgc gaagatggag ctgcgccacc 127680
tacatgacca tcgtattaac acctattgga gcggcatagt tgaaccgtcg gctacgaacg 127740
gtaggtttca atatagagaa ctctctactg ccatctagtg cgcttataat tatatacagt 127800
gacactgttg cttgattaac cccttcgcga cagtgtgcaa atagagaggc atcactatta 127860
atactatcac agatcctcta gcgagacata gtaataataa cggtgtgatt agttagcgtc 127920
attgctgcta ttctggccgt aatgcggtga cgcatcgcct atattgctaa ctaggggtta 127980
gttatcaaat cctgactcgt atttcctata ccactagact cgttacgatc ggaccgcagt 128040
ctatacgatc tatcaccgtc tagcgaaaca aatgagtact atacctcacc ttagctgttt 128100
tctcctgagc tacttttcta acaccatcta gcgatgcaac tgagtactac atatcacctt 128160
agctacttta ctatttcttc ccctgccccc atctaacgat acacatcacc ttagttactt 128220
tacaacacca tctagtgata caaacgatca ttgcaggtga gcatttccgc acggccacgg 128280
ccgtgcagta ggaaggcggg tctatgggca tagaatagac ctatataggt cgtcgtccgc 128340
tacgatgcgt acctagtata cgagacggtt aatttgcggt tacgtggttg gccgacacct 128400
ctcatcagat ctaaaaaatc agagtaaatc ttgccgatat cattggttca tttaaccaac 128460
atcatatagt cgcacatgcg atcgtgtgta tcgattaata aaaataaaaa aaaaagaaag 128520
caaagttgta tgtctctgag tacttactgc gcggcgcctg cgatgttatt cggcaagcca 128580
gatcggtcga tttttcatgg ccgatagtaa aaatatttgc ccagtttagg gggcgggggt 128640
atcgaccccc ccgggcgtag aaacgggcaa aaaaaaaaaa ccaattttgc gtagaggttt 128700
gtaccgtcgt taagacagtt cagccgttcg tgcattacat ttatataagc ctaggattta 128760
ttttgtactc gctttaaaca tactgtgtca tgtttcaaac tttccgcctt tgagcggata 128820
ggtcgcctta gatagagttc aatttgattg ggtgagacat ataggcgcta ttatgttttg 128880
cccgggtaaa tgtttgtcat caaggcggca gtattgacaa agaatcgggg gtgtccggcg 128940
ctgctaatag atcccgtaaa attcaatgta caggcaataa aacacaatga acggaaaccc 129000
tcattacctt ctgtgccccc ggaataggtt atttaaatat aattagcgct gtatgttgcc 129060
attcttatta aaaggctgag tcactatgtt ctgaggaaaa tatatccgtg tacttaaata 129120
cactatgtac acttaagaca aactgagcgg tttatgaaaa accattaacg acactatccc 129180
tgtgaattga aagatatgat ctaggtccac cattcccctg attatatgaa tcggtcctat 129240
agttggtttt gcgagacagc tttaaattta aatttaaagc ccccaaaagc catcaactgc 129300
tttattcagt gctggtgtgc cgccagccct caattcccat cccgctgctg ttcggcctta 129360
ctttccagga acgtggcaat aaattaaagc ctattagttt aaagcagctc tgctgtgatg 129420
tagcagtttg ttcaaactgc agcagaaacc acagaaagaa aaaaaaacaa ccagacacaa 129480
aacgttaaga gaatatggat tttattatac tcgcttataa gcgagttaaa aactataact 129540
atgttaacaa gttcaatcca aaatgccaga cacaaagtac tggctaaaca gtttaaaaca 129600
cgatcatcgt taacgccaac acggtacagt tgaagctcat acattaagaa acgccagatg 129660
gcaaaataca agatgagtca acaccgaagg acaagatcgc tatcggcaaa ctttcattca 129720
taattacaaa ctgtactcct cgaccctgtg ataaaaacgc cattattcgt acaatatgaa 129780
tgacaaaagt cataaaaaaa atcattcctt gcagtcacca tcgtaatgtc ggatgtggat 129840
cccaatctct cttcccccat cgcgatagtt atagtcggaa agaaacggaa gaatttttgg 129900
aggcttaata cgcataacta aatgcagtga tagtcactga cagcggtgca gccgtatcgt 129960
aaaagtggcg gcgggagcgc gacgacgctc gctaagcgac ccctcctcgc gccctcgtcg 130020
ccggaaacgg ttcgtaggaa tggggaaagc atagtagtct gctgccagcg attaggttgt 130080
atcccatttt agtccacaac acgaccccgt tcgaccgttt ttcctctcct cgcgatctaa 130140
aagagtggaa aaaacaatca ttaaaaattt ggcagtgata tgcgaataaa aaccgagtct 130200
cagttcgaaa caatcgctta ccagaaagcc gccagtcatt ctcgcgctat cgtttatgag 130260
aaagggggcc gtgtagtcgg tggtagccga accccgacta cacggccccc gtatcgttac 130320
gtcttgaatg gtcgctccgt ctgtaccgcc ttgacggtat ggactaaatg ggctcgggtg 130380
ccgcttttta tagtctcaaa gcgccttcaa accacgccca cttaccgaac ccggaccgtt 130440
cgcactctgg tttccaataa tatattataa tatattattg gcttcagagt gcgaacgcca 130500
gatttgacca atcgcattag cccattctta ccacatgatc taattaagca catattcgca 130560
ctccgaaata ctgtgttgga aaacggccaa ctttctattt cacagtgcga actctaatgc 130620
atattcataa ccccacgacc acgcctttaa agttgaatat tattaaggcg tggttattcc 130680
cagagctgcc ttcaaactgc cataaccagt tgacgcaaca taaggtaggc gatcgcgtgt 130740
atataattat atcattgctc aatacgggaa gtattgctta atatggttca atatgaccgt 130800
aacttgacct ttcctcctct caaccaacca ttttacaggc ctaaaaagca ccgcacgcta 130860
gtgtctatac tgttcgacga tacttcggac gaccgtaccg cggacagaat tgatatacgg 130920
ttcgcattcc tgaataaacc attgaaacct cgaccattat acgatcgcgg aatcgcgttt 130980
aggatggcac caaactaaat aaatgattca tggtcaatat ataaaaggct ctcgtttaca 131040
gaactgcgat agacatggcg acggcatcgc gacggccaag cggtcaagcg tgcgaacaaa 131100
ctgtaacggt atcgtatgtt caaggattga gtaattcacc gtctacatcc accgctttgt 131160
ggtcatcacc accggcaact ttgaccaaac cgtctataga atcgcctaga agacaattgg 131220
atccgcgcac ggtaaagccg aggcaacaaa tgtcgccggc tggaggagat ggcatgtggg 131280
atctgcataa gtccatcact gtagatcaca aggaatacgg acctcctgta ccgccggacg 131340
aagcccgcag tggtatggat cccaaaatgg gacccggcgc gttttgtgct tcgccgtggt 131400
tacccgacgc aactcgacta ggtgacgatg ttaacctcgt gtttaaagct ataatacgag 131460
catccggatc aactgggcgt tattgccggg cctttcggag aagtttattg gaattttacc 131520
tgatcgggcg ctatggacca cgactgccgc gcgagggctg ggaagctact ttacaactat 131580
cccccaacca aagtggaccg ctccgtgctg tattgcgcga ggcggacgga cgtatagtga 131640
acaataccgg ctatatggaa gggccgtttg ggcccaccga agcgccgtat ggagcagaat 131700
gtgaggtcga cgggggatgt tattctgacg atgagcgatc ggaatgcgag tcagatctat 131760
cggaagggga catgaacttc gtgttatcgt cagatacgga aagcgagcgt ggctacgatt 131820
ccgacgcgtc ggtacgtagc gtcacatcaa gcagccatag taattgtgac gatgttgact 131880
atgacccgct gggcgacctt gattcagaag aggagatgac ctcgtcggta tctacctccg 131940
actctgaaag cgaagttata gaggttatag ggaccaaacg caaacggccg accacgagga 132000
gtatgagcgc actcgcgggt accacaaaac gccccaagag ttaataaacc tgtcgcgata 132060
tatgctgcaa gcgcgtatta accttttgta gctatgcaac tcgttgggta ccgcaaacgc 132120
ccaagagtta aaaaaaactg tcgcgatata tgctacgggc gcgtattgac cttttgcgat 132180
tgctatgtaa ccagttgctg gctcctgttt gccccgccca ttccatccaa ttgatgtcaa 132240
taaacaccgc ttaagaaacc gacgccggca cttgtttact gaagggaggg acggttgggc 132300
gtgggcgagg gcgtggggga aacggccagc ccgcggcggg tcgggtaaat ataaatgaag 132360
aggcgctgtc tcaatcttat tgtttattag tatactaata acaataacag acaaatgcat 132420
gaaattacag aaaatatgaa aatatcacaa atggccgacc accaagtagg tttcatacac 132480
tctgtgcggt gttcaggtag cactatattc ttcgcgcgat cgactacacg acagttttcg 132540
aatagcccat caacataaca aggatgacaa atgtaacggt cgccgaggca tatgtctggg 132600
cgtaatggaa ccgaaagacc taagttggca ttaacacaaa gcgagtactt ctctgcgtcg 132660
gtcattatat tccatctgcg tgaccggtct gcgcttgata gtggtctagt gaggcactgt 132720
cgccggctag tacatctgcg cattccgaat ggattccaga gcagttgtag gtacaggtat 132780
caaacgttct atcccttgta ggatgcggta taacccctgt ataccaggtg tcggcctaat 132840
atacctgtgc attagtaata caggtaacta tttcactagt gagtcattag ttcaacatcc 132900
atgatcagat gcggaaacta gatttgcttg ccctctgttc atgaggatat ggtggaacgg 132960
agaactcgtt ctcaaaagaa tcgtcggaaa agtctccacc attttcacag tcactatcac 133020
tgtatgactc gacgccgggt aatgaattgt aatacgagcc gtatgcattc ttgatgccat 133080
tgcttttcga acgcgctctt gccctaagga atttagtagt taaaaagatg gatgaaacag 133140
ccaggattat aatagtcacg acccctagta ctccgagacc gactacaaac agtccagatc 133200
tgccgtcatg ggtaccgcgg ccaggtgtag attcggtaga ctttagcatc gtatcttcag 133260
caattgcggg tttatgagtt tcgatggtca cgccgacaaa tagatcaata gttgatagta 133320
acgtatatgc ccacgatgtt attttatcat ctatcgtgat aattacgaca tatagtcctg 133380
agtctgtgtt ctgaggattc gtcagtctta accctatacc cttttgcatt acttgtattg 133440
ccgcattatt atcaccgtct agctgttccg attgacatga tgcccaacca gcacccgtct 133500
cattgcaatt gctgatcttt ctttccccga ctatactggc gttcaacgta gatgcgaatg 133560
cgcaatttgc gttttctggg aaaagacatt cacgttcaga cggatgaaat aaacacggtt 133620
cataaagcga tagtataggg catgtgttgt caactatagg cttcataaac cactggatag 133680
tcatattata aggtccttgt atgtggtaga tggataagtc tgctgtcacg ttcatatctt 133740
cgccggcatg gaataggact gttttataca aagaaatgat agcttatgcg tccatatgtt 133800
taggtgtaat aggagcatat gttggcattg gcatcgcagt cggttttagc gcaccgtctt 133860
taagtgtaag aagaaatact tctgtcctaa aatacgacga atcatttata cgtgcgtgta 133920
gtagatagag tccttcgttt gcttctgttg aattagtgat ctttataccg cgtatgttgg 133980
ctccaagtat tggatagaca ttagaatcgc gggtaaaata agcatgatca agttccgtca 134040
gggctgagtt ttcatgtacg gtgtagtaag cgattcctag cggaacggtc atatgtccat 134100
ggtagtcgca atccttgtcc attaccaaat ccgaaaagca gtagattgtg tcgagacaga 134160
tataggccgg tgctacggct ttgcattccg tagttttggt aaatgaccac gcttctttga 134220
agcgggatcc gacggtcgta ggcaacttat cacgtatttt cggctccagc gttacatcct 134280
gaccggtagt tccaatcact tgatgatagt ctgctataca acagttcaac atacatgtta 134340
ttatgcacac agctgtagat ataaaagtaa ccatcatcgt accaattgtt gaggttccgt 134400
agtctggccg gcagtatgtt ggtgtttagt actccaacct ccgcgcataa tacagttaac 134460
caggctgcac acttaaatta gtacagatct atagctccac ccatagccta ttacctcatg 134520
tacaaatata tttggatgtt aatgaaaggc aaacagtcaa tcataacaaa aacatttact 134580
tttagtcata ctgatgtgaa ttattctgtt ttatgatccc cagagctgtc atacgctgcc 134640
agtttttcct ccagctttct cattagggta ccatctagct ccggatgttt tgattccaga 134700
gcgccttgag aaggaggatt atccagtgcc gattggttga tcacgcttgt ggtagaacct 134760
gtataaacac gtcgtttcgt acaacaacta cataatttgc gtttaagagg agagcacatc 134820
aacacgatga atatggtcaa cggtagtacc acaaacatta cagctgggat aagatagata 134880
tttggaattt tgtcaaagat attaagtcca ctattggtat cattatgcgt aggctgcata 134940
tcatcagata atgttgtgta attgttagtc gtaggaacgg tcacaggctt catggtcgag 135000
aagccttctg tagatacctc ttctttcaaa tgcttgtcat cctccaatgg tccagaaatg 135060
cccatgagat gatagtcgag aggaactcca gaatagaagt catagtgatg gcatatggaa 135120
cctacatccg ctacaactcc gaaatcttcg ccgacgggtg gccgttctgt taccttttca 135180
taagcgttat catccggggg gactactgca ttaattttgt cggtaattat aactgtcgtt 135240
ttaaacacat ccggtactac agcatcgttc acacttactc tgatataata tatccccgaa 135300
tcgtgtatag atggagagtc caatacaaac aacgcagtgc tacttagaac atctttcagg 135360
tgtggtcgcg ccgggtcgaa atagcgtgta gcatgtctgc aggccttgaa ggcagttgct 135420
ccaagacgag ggcaatcatc atatatagct gcatacgcga cagaatagca gtgacgagaa 135480
atattatata ctagtagctc gacagttcca ttgtatactg gcggtagttc ggcctgtgat 135540
ccaagaaaaa gtagttttcc ataaactgcg tgtctgtctt ccacggccgg tattgacgca 135600
gaagcaggtt cctgtagata taagcttacg gacgtcccag catacacgat tgcattgatc 135660
gttgttatac agttaatcgc cgaaacaagt atcagtatat gtcgtgtcgt tcccatttct 135720
atttttgaaa ctcaatatat cgtctatatg gcgcactgga caatactgga agtacgcgct 135780
cccagtaata cactaaaaga actacagacg gccgcaagag acgtgtattt tatgtccaca 135840
taggcgccgc ccagtcaagc ctatcctctt cgtcgaggat tttgtaagcg cttcttactg 135900
gtcttgtatt tttagttttg tggcggcgct tatcatcttt ggttgttaaa catatgtaga 135960
tgacccaccc acaaatacct aatactatac agatagacac tacagcgatg ctaatataaa 136020
ttgctgtttt ggacgtggcg tttggcaaat cctcatcttc gagaccggaa tcatgggccg 136080
gttgcgtagt aattatatgc gataaccagt tgttaggtaa cttaggcctc caatatgatg 136140
gctcatcctg aggactacta gttccaacat agctttcagt gtcgttttcc cggattattg 136200
taatacttcc tccgttaact tcagcattat gtgcatgtcc atggtcatcg ctcgcggctt 136260
cgttatgtgt attactacta gtacgcgtta tgacgttgtc gtctgtatat gttttgggta 136320
caacggcgcc acgctggcgc atccagtact ctactattgc cttgtgcata ggttgttcaa 136380
agtaacttgt gaggcccatc gtcttctttc tatttgcaac atcaatctct ttttgagtaa 136440
aacaacgatt gctggtggtc gggtccggct tcccgaacca acacgatgaa ttaatgttaa 136500
cttcaaaatc agaataaatc ctgtcgccat taacttccaa aacgcgtgtg tattgtccac 136560
tatgccatga cataggtgcg gcaatgacca gtccgagttc gtcatctgtt tggaacatga 136620
aactcgagaa cttaaagtcc caccacatag ctgatctaac tttacagtcc ccaaaaacct 136680
gtcgtaatga acaattccca tattgtatag tcattatcgg gtaggcacaa cccactccga 136740
ctttgaacca agatattgta gcgttatatg tagacatacg gttaagcaat gtccccaaca 136800
ttagtcggtc gagtccttcg cccggtatta gcgctattgt agaacaatca cctgtatatt 136860
caagcgcctt gacatacgtt gcagacccct tcggtctttc aaatggcgat gctatccacg 136920
tgccgggcaa tgtccagtcg gtcttatgag taaaacgcgg gggtggtaca gacggcggtg 136980
gaatatacac cgttgtagtt tttcgttgtg taactgcatg attgccaata gctgcaaggc 137040
tagtatcgct ataataaatt acgatcaaga acaatatatt cgctgagtat ttattcattt 137100
cctactgaga tgttggacca tcaaatcctg ggtcttaccc caattaaaac aacaacagaa 137160
ctgtaatggg tacattaaac atacgcgcat atacatattg ccgtcatacc atacaaaggc 137220
ataggtacag cccacaggtt aaaaacaaag aaactgtagt cattaaagcg gccatggccg 137280
acattgacca tgttgaaaat ccttcataat ttccgcggaa ccactttcta ctaacagatt 137340
cggcataacc gtctaaagtt cttattgaac atatataaaa cacattgtcc cggccttcag 137400
cacgtggcat cgcaattgca ctgtacattc gccagcactt atcccctggt attgttatat 137460
tagtaaccgg tccagattct attttcgttt catgcacgac ccaagagaag attgggactg 137520
tgtcaagatt atcggcctta cacatggcca catgacgcaa ttcgtcaaac tctattgcca 137580
aatgtttacg tgaatagcat gggattgcag catcgaccga tatgcaaact gagcgcccat 137640
tctcttgcag gtgtgaaaat tcggaagcac atatttcgca agttataaca gattttatgt 137700
ccgccacagt ctgattgata tggactatgc caatggtcgt tctgtagtcg ttaacagtcc 137760
aatgttcttt cttagtcgta acatcaatta tagctttatt tacataccag ttaaacgagt 137820
atgtgtagtt atctagcgtt gcgacatgac attctgctct gagagcctta tggggttcat 137880
caggtggaat tatcttcagt agtgtcgagt ctctatcagg aaacggactg gtcgtgttgg 137940
cgaatgctat atggtggtaa tgtccggcga aatgatcttt atcttggtct tctatttcag 138000
cgctttccgg aaagtcttca ccagaattgg gccatctggg tatccatggg tataataacg 138060
aaccattgtt tgtggcttct atatattcat gagagcatgg tgcggcgctt acccatggat 138120
aagcagttaa gctagtgtcg tcgataatgt ctttgggagt agaaaatctg gtatatatgc 138180
cagtatcggc accacttaaa ctatcattta caattagtct aaacagcata atccgccgca 138240
atccgtacga gtatattata gtcttctcat atattttcgc taccaacaaa gaattattta 138300
gtgttttatt catggtaata tttacatcga atcgtctagg ttgatgggat acattgtata 138360
tataatccat gcgccacatt tgggggatcg tggtttatca tggttgaacc attaaaagag 138420
gctatttcat aatagtgcca ggtagagttt tctggcttta aaagtgttat gttaaaatat 138480
tgggtagcgc tacttctatt cctacctcta aacgacaaag gtattgtcac gtttgccgca 138540
ttcggcgcat cgatacgaat acatctcgtc cggttagaga ttattgtgaa gttagcaccg 138600
ttgtaaattc catctggtgg cgcttcagcg gccgaggtac ttgacgtggt ctgcggtgtc 138660
gcggtagtaa ccgaagctgt actcgtccat ggttctgtaa cagtcgatgg gttcgtagca 138720
tctactccca acgacatagt tggctgcggt gaagttggcg agcattgaat gctcatagta 138780
aataaaatca cggctaccca catgaccgta acgtctgtat acatcctgca tgagataagg 138840
actacgacag gaggcctaca tcgcttgcat taaattactc tttcatttta accgtttaag 138900
tcaacattcc gcgtcaatat aaacacaaga cacacacgtc atttaatatc tttatttaaa 138960
aatagctgtt taaacagatg attttaaact aatggaacgc gttggaattt caagtcttgg 139020
cgcccaaaca tcgattgatg tttggtcaat cgcgtaacaa cagatcgaag atatagaata 139080
tacatcccaa gaagaattat tgtcacgata ccaaaacatc cgatagtcac tattgcaatt 139140
aaaccactcg taccgataca gcgccgcgca tcttctacta gagcggcaaa tagtagtggc 139200
tgatctatca tactgtcata ggtatgtggg ggatgagggt gattgtggta gcttccatgc 139260
gaatgtgttg aggtggtatt aatagttgta catgtcgata ggttcgccat tttaagacca 139320
atccgcggca tccttccagt agaatgtacc atgaaactgg cgagtaacaa atacccacca 139380
gtttgatttc tgaaattggc attggtttta ggtactgtcc atatgtccgt ctcatttaca 139440
cattcattat ctatgtcatc atagcattca gatccatgat ctgtagagcc gtagtcttca 139500
taaccacacc gggggaaacc aagcatggcc ggatcgacat tgcgttcatc ccaagactca 139560
ctctcgtccc tgatttcttc gagactcttc accagttgac aaacggtctc tgtgccattt 139620
tggaaactaa atcgtatctt cccgtctttc gtactaatat tatacgtatt gggatggggc 139680
aaaccatctg gagacatcca cgtacctata tcaacaatgt ccaggtcagc gccagacgtt 139740
ctgccaaatt tattaacgca ataaggatcg tctgatgttt caaaagttac atttagtgtt 139800
ccagtcttcg tattattgtc tgttcttaga ataaacttat atagtccact attatacatc 139860
ccactagata taatcaagcc agtaccatat ggtagcgtgt ccatttgtcc atcaatataa 139920
taggaataaa tatgcgaata gccgccacag gtccatacag acggctgatc cccagagcag 139980
ttgtagtatt ccacgtagcc aacaggcatc gtgcaattag cggtgatgtg ataccaagta 140040
acagacatgt catatggcgc accattcccg gcggaaacac tggaaatagg cgcgaggagt 140100
gtaaggtcgc accattgaac tgcaatatcc atcgttccaa tgtcctcata tcgtcctgtg 140160
tgtggtggta tcctcccagg cggtccgatt ggcaacggtc cgtccaaaat agccctggcg 140220
ccagctggta taactacacg tcttgcatgt gtagcgttgt cccatgttcc aagatgaatt 140280
gggtccttgc tgcggctatc tcccattgcg atgcctaaaa cgcatcccaa aaaaactaac 140340
accacagcta tcattgttgc cataccagct acacaagcgc ctctatgatt tcaacactcc 140400
agcggcgcgc ccgacccgga gatcgccgca acgcgcatag ctacttgtct aatttataca 140460
cttttttaca aacttgactc ctcccatata ttaattgtaa tttacccttt gtgggtaata 140520
acggaaagcg aaagcagatc gtctgccgta ggtcgccttt gttgatcaaa tgtcaacatc 140580
ttgcatatca gatattcggc gtccatatgt aatgtatatt tacgtatcaa aggcgggact 140640
gtatatggtt tgcgcttaac ttctgaatac tttccatatt cctttacaat acggcagtta 140700
ccatttactg gaaactcagc cggatgtact tgcatggcct taattattcc acgtaattga 140760
tgactactat acccagaggg gtttttgatc ccaaaaagcg aaacacgttg tactagcatt 140820
tcaaataaca ctattccagc gctccatata tccgtctttg cgcaatatgt atccaaggcc 140880
aacagttcgg gagaattaat ctcaagcgtt ccaacccacc catagtcttg aggtgtatac 140940
ggcgatgccg ttgttttaca cgcagcgccc aaatcgccca acactgcatc attcggttcg 141000
ttgagaaata tattttcaag ttttacgtcg cggtgtatta ttcctcttcc gtgcaggtaa 141060
ctaagtgcct ctaatagtcg tttttggata gtaaatgcgg tttctagact gaggggcgat 141120
gaacgctctt cgacgtatgt atataagtca tgagtataat gtggcaatac cagacatact 141180
aatggaccgt tgcgaaatgc atcaatagca ttaattatcg ctctgtggtt tatattacgc 141240
aaaaaccgcg cttcggtttc cgttccacct ttactgcccg ccttgactac tacgggtgta 141300
cgttgttcat cgccatgttt cacacataca aatacttctc cttctgcgcc aggtgttagc 141360
gttttcaata tttcatattg cgtattcaca accgccgcca cgtcagacga cgaagtatat 141420
tcatgtggag attgacaaac gtcggtctgg tcggccaaag attcctcatc tccatcataa 141480
tcagttgcat gtgtgtttga atcagacgtg aacagttcat cacaatcgtc aaatttgtcc 141540
ccggtgtgat tcttccgatc agacgtgtcg ctcccgcctc gcaaatcgaa ttcggcaaaa 141600
gcgcccaaac atattacctc gtcatcgaac tctaatgtat cggtatgaca cgtttccatt 141660
tcatttgagc tgcgtccgcg gcagttttgt atgtttgttc tcgtttgata tgagcaatca 141720
tctaaatcat catacctcgt tttagacgac aactgttcca ttgccaacga ttgtagacca 141780
caggaagatc ttacgaactc gccctttgac aacaaagtgt ctaaaaggca gagaatgtgg 141840
cttatgaagc agcataagga ggagacgcgc aatgggtgtg gttatattgt caatagccac 141900
cctgattgac gaaaatggac ggttacctgg cagaactaga gacgcctcgg tacatttatg 141960
ggacatttta tttaaacaat gtgccaaaat gatggatgat tcgctcggaa tccctgttgt 142020
tatcagaccc gcaaatctaa ggcgttgtgc cagcaaattt atgagcatgc cacgagccca 142080
cagacctatt ttaagactaa ccaaccctct gggaactggg gcaaacggaa ctggcctcgc 142140
gggaagacgt gatgtaccac cagtacaatt ttatgaagac ggttccgaaa gtacagaatg 142200
gacgagtgtt ttggctggct atgatcatct ttcgtcgggt atacttggga atcatacttt 142260
tgatatgtgg attattggtg ctgccgatat ctgcaagccg gcaatagaac aactgcccaa 142320
ttcaaaacgt ttcattacca tcaaagttcc aggcacatgg tctggtttga cgtgggaaaa 142380
cctgatggtc tatcacccct tactgtaacc gaatgggatc cttgtgacga tgaaaccatg 142440
agcaaagaca ttattgagaa aaagctcgtc ggcataaaat gttgttatga cctcattggc 142500
cagcccgctg ccgcaaaaca taatagcgaa ttggatgaca gcaaagatgt aaaatgctgc 142560
aacggccccg cctgttgtat agcctgttag ctttatatag caagcgcagc tgacaactgc 142620
tctggaatcc attcggaatg cgcagatgta ctagccggcg acagtgcctc actagaccac 142680
tatcaagcgc agaccggtca cgcagatgga atataatgac cgacgcagag aagtactcgc 142740
tttgtgttaa tgccaactta ggtctttcgg ttccattacg cccagacata tgcctcggcg 142800
accgttacat ttgtcatcct tgttatgttg atgggctatt cgaaaactgt cgtgtagtcg 142860
atcgcgcgaa gaatatagtg ctacctgaac accgcacaga gtgtatgaaa cctacttggt 142920
ggtcggccat ttgtgatatt ttcatatttt ctgtaatttc atgcatttgt ctgttattgt 142980
tattagtata ctaataaaca ataagattga gacagcgcct cttcatttat atttacccga 143040
cccgccgcgg gctggccgtt tcccccacgc cctcgcccac gcccaaccgt ccctcccttc 143100
agtaaacaag tgccggcgtc ggtttcttaa gcggtgttta ttgacatcaa ttggatggaa 143160
tgggcggggc aaacaggagc cagcaactgg ttacatagca atcgcaaaag gtcaatacgc 143220
gcccgtagca tatatcgcga cagttttttt taactcttgg gcgtttgcgg tacccaacga 143280
gttgcatagc tacaaaaggt taatacgcgc ttgcagcata tatcgcgaca ggtttattaa 143340
ctcttggggc gttttgtggt acccgcgagt gcgctcatac tcctcgtggt cggccgtttg 143400
cgtttggtcc ctataacctc tataacttcg ctttcagagt cggaggtaga taccgacgag 143460
gtcatctcct cttctgaatc aaggtcgccc agcgggtcat agtcaacatc gtcacaatta 143520
ctatggctgc ttgatgtgac gctacgtacc gacgcgtcgg aatcgtagcc acgctcgctt 143580
tccgtatctg acgataacac gaagttcatg tccccttccg atagatctga ctcgcattcc 143640
gatcgctcat cgtcagaata acatcccccg tcgacctcac attctgctcc atacggcgct 143700
tcggtgggcc caaacggccc ttccatatag ccggtattgt tcactatacg tccgtccgcc 143760
tcgcgcaata cagcacggag cggtccactt tggttggggg atagttgtaa agtagcttcc 143820
cagccctcgc gcggcagtcg tggtccatag cgcccgatca ggtaaaattc caataaactt 143880
ctccgaaagg cccggcaata acgcccagtt gatccggatg ctcgtattat agctttaaac 143940
acgaggttaa catcgtcacc tagtcgagtt gcgtcgggta accacggcga agcacaaaac 144000
gcgccgggtc ccattttggg atccatacca ctgcgggctt cgtccggcgg tacaggaggt 144060
ccgtattcct tgtgatctac agtgatggac ttatgcagat cccacatgcc atctcctcca 144120
gccggcgaca tttgttgcct cggctttacc gtgcgcggat ccaattgtct tctaggcgat 144180
tctatagacg gtttggtcaa agttgccggt ggtgatgacc acaaagcggt ggatgtagac 144240
ggtgaattac tcaatccttg aacatacgat accgttacag tttgttcgca cgcttgaccg 144300
cttggccgtc gcgatgccgt cgccatgtct atcgcagttc tgtaaacgag agccttttat 144360
atattgacca tgaatcattt atttagtttg gtgccatcct aaacgcgatt ccgcgatcgt 144420
ataatggtcg aggtttcaat ggtttattca ggaatgcgaa ccgtatatca attctgtccg 144480
cggtacggtc gtccgaagta tcgtcgaaca gtatagacac tagcgtgcgg tgctttttag 144540
gcctgtaaaa tggttggttg agaggaggaa aggtcaagtt acggtcatat tgaaccatat 144600
taagcaatac ttcccgtatt gagcaatgat ataattatat acacgcgatc gcctacctta 144660
tgttgcgtca actggttatg gcagtttgaa ggcagctctg ggaataacca cgccttaata 144720
atattcaact ttaaaggcgt ggtcgtgggg ttatgaatat gcattagagt tcgcactgtg 144780
aaatagaaag ttggccgttt tccaacacag tatttcggag tgcgaatatg tgcttaatta 144840
gatcatgtgg taagaatggg ctaatgcgat tggtcaaatc tggcgttcgc actctgaagc 144900
caataatata ttataatata ttattggaaa ccagagtgcg aacggtccgg gttcggtaag 144960
tgggcgtggt ttgaaggcgc tttgagacta taaaaagcgg cacccgagcc catttagtcc 145020
ataccgtcaa ggcggtacag acggagcgac cattcaagac gtaacgatac gggggccgtg 145080
tagtcggggt tcggctacca ccgactacac ggcccccttt ctcataaacg atagcgcgag 145140
aatgactggc ggctttctgg taagcgattg tttcgaactg agactcggtt tttattcgca 145200
tatcactgcc aaatttttaa tgattgtttt ttccactctt ttagatcgcg aggagaggaa 145260
aaacggtcga acggggtcgt gttgtggact aaaatgggat acaacctaat cgctggcagc 145320
agactactat gctttcccca ttcctacgaa ccgtttccgg cgacgagggc gcgaggaggg 145380
gtcgcttagc gagcgtcgtc gcgctcccgc cgccactttt acgatacggc tgcaccgctg 145440
tcagtgacta tcactgcatt tagttatgcg tattaagcct ccaaaaattc ttccgtttct 145500
ttccgactat aactatcgcg atgggggaag agagattggg atccacatcc gacattacga 145560
tggtgactgc aaggaatgat tttttttatg acttttgtca ttcatattgt acgaataatg 145620
gcgtttttat cacagggtcg aggagtacag tttgtaatta tgaatgaaag tttgccgata 145680
gcgatcttgt ccttcggtgt tgactcatct tgtattttgc catctggcgt ttcttaatgt 145740
atgagcttca actgtaccgt gttggcgtta acgatgatcg tgttttaaac tgtttagcca 145800
gtactttgtg tctggcattt tggattgaac ttgttaacat agttatagtt tttaactcgc 145860
ttataagcga gtataataaa atccatattc tcttaacgtt ttgtgtctgg ttgttttttt 145920
ttctttctgt ggtttctgct gcagtttgaa caaactgcta catcacagca gagctgcttt 145980
aaactaatag gctttaattt attgccacgt tcctggaaag taaggccgaa cagcagcggg 146040
atgggaattg agggctggcg gcacaccagc actgaataaa gcagttgatg gcttttgggg 146100
gctttaaatt taaatttaaa gctgtctcgc aaaaccaact ataggaccga ttcatataat 146160
caggggaatg gtggacctag atcatatctt tcaattcaca gggatagtgt cgttaatggt 146220
ttttcataaa ccgctcagtt tgtcttaagt gtacatagtg tatttaagta cacggatata 146280
ttttcctcag aacatagtga ctcagccttt taataagaat ggcaacatac agcgctaatt 146340
atatttaaat aacctattcc gggggcacag aaggtaatga gggtttccgt tcattgtgtt 146400
ttattgcctg tacattgaat tttacgggat ctattagcag cgccggacac ccccgattct 146460
ttgtcaatac tgccgccttg atgacaaaca tttacccggg caaaacataa tagcgcctat 146520
atgtctcacc caatcaaatt gaactctatc taaggcgacc tatccgctca aaggcggaaa 146580
gtttgaaaca tgacacagta tgtttaaagc gagtacaaaa taaatcctag gcttatataa 146640
atgtaatgca cgaacggctg aactgtctta acgacggtac aaacctctac gcaaaattgg 146700
tttttttttt ttgcccgttt ctacgcccgg gggggtcgat acccccgccc cctaaactgg 146760
gcaaatattt ttactatcgg ccatgaaaaa tcgaccgatc tggcttgccg aataacatcg 146820
caggcgccgc gcagtaagta ctcagagaca tacaactttg ctttcttttt tttttatttt 146880
tattaatcga tacacacgat cgcatgtgcg actatatgat gttggttaaa tgaaccaatg 146940
atatcggcaa gatttactct gattttttag atctgatgag aggtgtcggc caaccacgta 147000
accgcaaatt aaccgtctcg tatactaggt acgcatcgta gcggacgacg acctatatag 147060
gtctattcta tgcccataga cccgccttcc tactgcacgg ccgtggccgt gcggaaatgc 147120
tcacctgcaa tgatcgtttg tatcactaga tggtgttgta aagtaactaa ggtgatgtgt 147180
atcgttagat gggggcaggg gaagaaatag taaagtagct aaggtgatat gtagtactca 147240
gttgcatcgc tagatggtgt tagaaaagta gctcaggaga aaacagctaa ggtgaggtat 147300
agtactcatt tgtttcgcta gacggtgata gatcgtatag actgcggtcc gatcgtaacg 147360
agtctagtgg tataggaaat acgagtcagg atttgataac taacccctag ttagcaatat 147420
aggcgatgcg tcaccgcatt acggccagaa tagcagcaat gacgctaact aatcacaccg 147480
ttattattac tatgtctcgc tagaggatct gtgatagtat taatagtgat gcctctctat 147540
ttgcacactg tcgcgaaggg gttaatcaag caacagtgtc actgtatata attataagcg 147600
cactagatgg cagtagagag ttctctatat tgaaacctac cgttcgtagc cgacggttca 147660
actatgccgc tccaataggt gttaatacga tggtcatgta ggtggcgcag ctccatcttc 147720
gcatgaccgc cagctagcat aacttctcgt gagagcgcca ccacatggct aggtatataa 147780
gtgtcgggaa taatgctgcc tgatcatagg cttagaaata atgatatgca ctgcaggatg 147840
ttttagaaat attattattg gttgttgctt aattatacgc aaacatctac ccataaccac 147900
cgataatagt attcattcag gaaatagtaa gaataacatt attggattat ggtttaatta 147960
tatgctaaca tttacccgcc ctaagaaaac ttacccataa ccaccgataa tagtattcat 148020
tcaggaaata gtaagaataa cattattgga ttatggttta attatatgct aacatttacc 148080
cgccctaaga aaacttaccc ataaccaccg ataatagtat tcattcagga aatagtaaga 148140
ataacattat tggattatgg tttaattata tgctaacatt tacccgccct aagaaaactt 148200
acccataacc accgataata gtattcattc aggaaatagt aagaataaca ttattggagc 148260
gggctttaat tatattcgta tcaggaaacg aatagtaata atgttatcgg tgattgttta 148320
actatatgct aacatttacc ccaccttagg taaacttacc cataatacac aataataata 148380
tgcacaacag gaactgtgtg aaacattatc attggaaaaa acttaatcgt atgctactga 148440
acatgcaaat tgagtctttg cggaacttct ccaacttctt ggttggcgga cagttaatag 148500
aatgcaacta tgtgggccgc gatttgtagt tgggcaaatg tattcatttt tccctcgaac 148560
taagaaggca tcgttaattt tcctgtatgg gcgcggctaa agactacgcc ctttctatag 148620
tagcatttaa gtagaagcct tttcgatcgt tgcatagttc tactacgatc aacctatctt 148680
caactccggt ctaaccagcg ctcttcagcc ttctctctgc agttctacgg ctcggagtag 148740
catctgggac atattgctaa agactaaaag taagtttctt tgcaaatatt acaactattt 148800
tttatttgat aagtgatact acaatttgat ccatgatttg gcctttgagg tatttagaat 148860
cttaatatct taatctcaat tactacaagt aattgatcac ttatagtcct attaattaac 148920
tgtaatagcg gttaacatat taattaaact aatgtataga tattatccgc ttccagattt 148980
attattttgt aaaataggca cagttcttat ctggtgtcac tttatgcttt tttaatagac 149040
gcccagctct actcatggcc aagacgcagt acccagattt tactgacctg attgaggccg 149100
ccgcgagtgc ggattgtagt tttatgagca acatttcttc gattgatatt cagcacggca 149160
tccaggggcc caatacaccg ttgattgacg agtcgcagta cttactggac gactcgaggt 149220
gtcttataga taatgtaatg aatgctgcgg caatggcagc aactaccaaa cccatggaaa 149280
cggttaatag aggagatggg cgactttatt tggattatat gggaccgccg ctttccgacg 149340
ctgcatttac taaacccctg caacctaatc ccggccctac agaaattgat tcgagtgatg 149400
aagaaccaac cacctgtggc aatttaaacc ccataaaaga ggccacacca cctaaaatgc 149460
aatctccatc acaggggatg cggcagaaag gggacacaac acccaaaggt gttgtgcgcg 149520
ccgaaggcgg tccaaaaacc gggtccgatc tgcaaaagaa gagaaagagt gagtacaaat 149580
tgggtcgcgg ggggaaaaca atggctaaaa aacccggtgt gaataaaacg aaggtggcgg 149640
ccggtggtaa gaattatgcg ggcattgctg atgttattga tattggtgaa tctgaagaag 149700
aatgtagcga taacgggggg gcagcagtgg gtgttaaaaa accaagatct gccaccgcgg 149760
ggcgaccatc ggctcctgat aaaccgatcg cttcacctgc ccggtcaccg acagcagcac 149820
cgcccaagaa taccgctcgg aggcgccatc gctcaccatc ttcatcggca tcgccacccc 149880
ctgctagatg tgccgacagt tggcgcacca tgacacccaa gtcatcaccg acctctgtta 149940
cctcggccgg ttggtatagg tcgccggcgc gatcgcctca aactggtgtc gtggaacgtt 150000
ccggcccccc gtctacatcg ccaaggtctg cccccagggg ccgctcgccg cccgcgctac 150060
ctatagtctc atgttgctcg ccagccgcgt cgccgcgcag atctgtcgat cgggggcggt 150120
ccaggtccag ttccagctca tccacatcgt cgtcctcctc ctcctcggac gggagctctg 150180
tttctagggg accatcccca gaccgccctc caacaccaaa gcgcccccct ccatcattta 150240
ttccatctgc accaaagaag cgtaggcccg ccatgcagcg taaaaaggat aatgcggagc 150300
agcggtcccc aaagactgat ttatcaaaac tgttttcgca gcaattaaca cacccaccga 150360
ccagtaacac cgctgcaagc aaggccacgg gcaccgccga gcgcaagggc aagcaacccg 150420
tacgccgcgc agttcagcaa gaagaaaccg aacagcagcc ccagactatg gaacaaccaa 150480
ctatgctcgc gaatagccct cgcgagtcca ctcaatatca acacccatca tcagatgaca 150540
ccatagattt agtctcctgc gaacctcctc cagcgtcaaa taacgcattt taccagcgcc 150600
cccgtagggg tagggggaga cggccatcgg cgatgaaaag agtgtcatca tctagcgccg 150660
gagctgagtc ttgtatgtca ataggcgtcc cagaaatgcc tactatgaac ggacctttgc 150720
taatgacaaa tggggatcca tggcccgggt ctgagccacc gccacctggc aaggtgcggt 150780
atggcggtac tggggactat cgccaggggc tgtgggatga accagagata cggtatgcca 150840
gagagcggta tgccgagagc cgcggtccgg tggctgtttt tgtgggagag atgggggatt 150900
catcaaagca gtatgatgct cttgtaaaag cactatatag caatagtttc gatgctatgg 150960
gctggataca atgtaacaaa ataactggtg aggatctgtt attggagcaa gtttgtcaaa 151020
aacgatgcaa tctgaggggt ggtactggtt ccgggtcatt tattactgga agtgttgcgc 151080
gacctctacc acatattgga gatgcgatgg cggctggaaa tgctctatgg ggtctaccgc 151140
atgttgccgc ggccgtagcg atgagccgcc gctatgataa agtgcaaaaa caatttctgc 151200
aaatgtctct gcggagggcg tatgcttaca tgcttttccc cgcaaaggcc gttgatgcct 151260
ccgcatctct aacggatgac atttcttcca tttatcgccg aatgaatgct gtccgccgca 151320
gcatgcgcga agctaccgag ggtctgcaga ctgtgacggt tcgcggcgac tcgcagatag 151380
agccgcagaa cacaccgcag tccacggacc atctggcgac agagcagagc gcggcggacc 151440
ccgacttttg tgatcccgaa catgcatctg attactcaac cgaggaactg gcagatgcgt 151500
gcgttttagc ttgtaatgca gtaatagagg tattgctcga gtgctttggt ggtgccggca 151560
acattcctgg tatttcctca ctggagctgg acgctgcctg tccgtctgcc cagctccacc 151620
ggcatcacgt ccagcttcta tcatggataa aggaccttaa actgttgcct atatgtataa 151680
atgctatgag actacggggc gagctttcat cgtcgcaggg cattgaatca tgtgttatgg 151740
cgcttcgtgc tgttggtacg gtgattagca ctgtgagacc ctttgtaaac ttttccgtgg 151800
acagggctag gcgtagatat tctgcatgga acctaacaga ggcgctcttt tctgccccga 151860
gcggaaatgg gtcagccaag atcaatggcg ccaaactatc ctgggtgtta agtgatgata 151920
ctgccccaaa ggaccgagat agaccagatg gcttgccaaa acatcagaat atacaaaatt 151980
ctaaaaagga taaccaaacc gggttaccgc ggacactgcc gtcggtcaag gctctcggtc 152040
caatgccgca aggcgggccc catccccgcg ggggatatag gcgcgtcccc accggaataa 152100
cacatactcc gctgccaacc gagtcggcac ggtctaccta ttgccagccc gacatagtcg 152160
cagaattatt agatgaccct atgtttcctc ctaactggaa acccgcttta atgtttgatc 152220
cggaggcact ggcccgcgtg gcggcacgac gtggcggaag ccatgtcgaa ggaagactat 152280
acgggcccct gcgagtcact gatccgctcc gcaaacaatg tgcttggatg aaccagattc 152340
cagaccctga ggatgtaaag gtggtcatca tgtactgccc gctcgtaggg gaggaattaa 152400
gcgccgcccc agtggcctct tgcatgccta tgtggtctga tgaaaaaggt ggcctctcct 152460
tcctgctagc cgccttgtgt gaccgccttt gttcatacgg cagtcacgca tgggcgggta 152520
actggactgg ggtcccagat atttctgcac tcaattccag gggcgtgctg ctgctatccg 152580
ttagagattt aggatttgcg ggggcggttg aatatctatg cctcaggctc ggctcggccc 152640
acaagcggct cattttcctg gatacaattg atacagtgga ttggcccgcc gacggtccag 152700
caattagtag ctatcattca tatataaagg cgactataac tccccaggcc catggggccc 152760
acagatggcc agattgtgaa gccatgtcaa gggtagtgat gacatcacgt gggatagtgg 152820
ggcctggagt ctttgcgcgg gtcgaagccg cgttcgctca gctataccct aatgaacccc 152880
cattacagct gatgagaggt gataatgtta aatatgttgt cgagacaaag gccggtcgca 152940
ctactcgcgt gccaatgacc ccccgtgaat atcgcggcct tgttcttccg caatacgacc 153000
gcaaggatat ggccttccag gcagatggac tcagtataag cggaccagat tttctagaag 153060
gggctgctta taatcatagg gcagcaaata gatggggtct aggagcacct ctgaggcctt 153120
tgtacctgac agagagccgg aagcatcctt ttgagacccc agatgacatt ccagaagtag 153180
tccgctcata ctgtgcagct gctttactcg aaccgcaaat ggagggtaat gtatgtgtgg 153240
tcaatccaaa tactatccag cgcggccaac gtccacctac aataacctgg gaactatgtc 153300
acggggggtc tagggctact agcatcgagg ccggagatat gaagcaggct attatcccgc 153360
ccaatgaaca atctaatgag gatgatgtta caattactgc cgtacagcca tctataactc 153420
caatgcccaa agcaccacat aagataaaaa ttgagatctt gtccgatggg gatgattcgg 153480
gggatgaggg caatccgtac gcgggagctt gtcgtgactt tttctgattt tttgttaaga 153540
gatttttttt acctgcaccg tattatatat tctccatttt tttagacagc cttttataca 153600
cagaaaatag cttcgctatg tatccagttt ttaaagaaat agaggtcttc gacatattca 153660
gctcgatagt taagaataaa gtctttttaa taaatgcaat ctgtcttgta gttcttattt 153720
aaaagtgacg ggcgggaata tggccgggcc aaaaagttat tggtggaatt ggtaggttgt 153780
ttggagattg catggatggt tattagatgt atagaccacc gcagctgtct ccaaaccatc 153840
caccccatcc caataagtgt caaaagtcta aatactatgt aagtccgtaa aggaatatta 153900
gttacaaaga tcactaaacc gccgaagttc atgggagact atcatggctg tcgggcaact 153960
accgctttat atttcgtttg taccaagcgg agaggctggc cgacattcat gatagtaatc 154020
cacaggtcct aattccttaa cacacatagg ctgcaattga cgcaaaaaga gggaggtaaa 154080
ataaagtgat aacagagctc tgataaagat aacgccatta caggcatcta attggattag 154140
ggttagctcc aactcctccc aacgccccca gtcctaataa ctatgctacc cggctcagta 154200
gtacctactt ggataaaggc caggtagaat ctggctacag tcaccatcta ctcggcgtat 154260
ggccaaccct agccctatta gcgcctcggc tcaatatttc ctacttgggc gaatgccaac 154320
cctaaatcag atgcagtcgc cgcctatttg gtgtattgcc aatcctttgc cgagttctcg 154380
gatgaagacc cgccccgctt gccatggggc caatcctaag agcgaactac cttcggagtc 154440
ccgtctcccc aaccctatcc aataacatta cttggcttaa ggccagccct aaccctaaga 154500
cagttctgcc tttggaacct tgccaaccct acttggctta gggccaacac tatccaataa 154560
cattacttgg cttaaggcca gccctaaccc taagacagtt ctgcctttgg aacactgcca 154620
accctaacca taataccgta aaacctttgg aacccggcca accataaccc taataccgta 154680
caacc 154685
<210> 2
<211> 711
<212> DNA
<213> 人工序列
<220>
<223> UL1序列
<400> 2
ctatcgtcgg ccatggtgtc cgggttcact tttgtcatgt cttcggccat atctcgagtc 60
tggatcgaat gcataacgga tgctggcctg agggtctttg aagcgatgca tattcgcgtt 120
tccgtggcag gttctgtcat ttgggtctcc ctcgttgaca cagccagtac ctacaggcgc 180
agtactaaag ctcggcttcc cgccccacgc tgaatttaag gctttctgaa aagccttgac 240
ccccacgtca tcacctattg caacttcaga gtccagcaaa aacccagaaa tcgcaaggtt 300
agggttgacc cataatgccc gctgtggacg ctcataccac aaaactacct caatttgggg 360
acagtgactg cggataaata ctccagacaa caactccgtg ctctttggtg gtacagctgc 420
ataggttgaa gtctccgagg tccctgggcg gaggcagtcc ctagatagta tagacaggac 480
atctggagca tacataactc cttcgataac cgggtaacta caggaagttt cttcaaaaaa 540
acccattacg actaggatca cgagcgccaa tctatgtaaa gtccaaccca ttgtcccgca 600
ccacaagttc ggaacgtttc gttcttcggc caccggacgc actacgtgta taacacgatg 660
ccgtattata cctacaagtg ttttcaagac ggccttccat ctggaaccca t 711
<210> 3
<211> 587
<212> PRT
<213> 人工序列
<220>
<223> VP2蛋白的氨基酸序列
<400> 3
Thr Ala Pro Ala Lys Lys Asn Thr Gly Lys Leu Thr Asp His Tyr Pro
1 5 10 15
Val Val Lys Lys Pro Lys Leu Thr Glu Glu Val Ser Ala Gly Gly Gly
20 25 30
Ser Ser Ala Val Gln Asp Gly Gly Ala Thr Ala Glu Gly Thr Glu Pro
35 40 45
Val Ala Ala Ser Glu Met Ala Glu Gly Gly Gly Gly Ala Leu Gly Asp
50 55 60
Ala Ser Gly Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp His
65 70 75 80
Cys Asp Ser Gln Trp Met Gly Asn Thr Val Ile Thr Lys Thr Thr Arg
85 90 95
Thr Trp Val Leu Pro Ser Tyr Asn Asn His Ile Tyr Lys Ala Ile Thr
100 105 110
Ser Gly Thr Ser Gln Asp Ala Asn Val Gln Tyr Ala Gly Tyr Ser Thr
115 120 125
Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro
130 135 140
Arg Asp Trp Gln Arg Leu Ile Asn Asn His Trp Gly Ile Arg Pro Lys
145 150 155 160
Ser Leu Lys Phe Lys Ile Phe Asn Val Gln Val Lys Glu Val Thr Thr
165 170 175
Gln Asp Gln Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile Gln
180 185 190
Val Phe Thr Asp Asp Glu His Gln Leu Pro Tyr Val Leu Gly Ser Ala
195 200 205
Thr Glu Gly Thr Met Pro Pro Phe Pro Ser Asp Val Tyr Ala Leu Pro
210 215 220
Gln Tyr Gly Tyr Cys Thr Met His Thr Asn Gln Asn Gly Ala Arg Phe
225 230 235 240
Asn Asp Arg Ser Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met
245 250 255
Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Phe Asp Phe Glu Glu Val
260 265 270
Pro Phe His Ser Met Phe Ala His Ser Gln Asp Leu Asp Arg Leu Met
275 280 285
Asn Pro Leu Val Asp Gln Tyr Leu Trp Asn Phe Asn Glu Val Asp Ser
290 295 300
Ser Arg Asn Ala Gln Phe Lys Lys Ala Val Lys Gly Ala Tyr Gly Thr
305 310 315 320
Met Gly Arg Asn Trp Leu Pro Gly Pro Lys Phe Leu Asp Gln Arg Val
325 330 335
Arg Ala Tyr Thr Gly Gly Thr Asp Asn Tyr Ala Asn Trp Asn Ile Trp
340 345 350
Ser Asn Gly Asn Lys Val Asn Leu Lys Asp Arg Gln Tyr Leu Leu Gln
355 360 365
Pro Gly Pro Val Ser Ala Thr His Thr Glu Ala Glu Ala Ser Ser Ile
370 375 380
Pro Ala Gln Asn Ile Leu Gly Leu Ala Lys Asp Pro Tyr Arg Ser Gly
385 390 395 400
Ser Thr Thr Ala Gly Ile Ser Asp Val Met Val Thr Asp Glu Gln Glu
405 410 415
Val Ala Pro Thr Asn Gly Val Gly Trp Lys Pro Tyr Gly Lys Thr Val
420 425 430
Thr Asn Glu Gln Asn Thr Thr Thr Ala Pro Thr Ser Ser Asp Leu Asp
435 440 445
Val Leu Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr
450 455 460
Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Lys Thr Asp Gly Lys Phe
465 470 475 480
His Pro Ser Pro Asn Leu Gly Gly Phe Gly Leu His Asn Pro Pro Pro
485 490 495
Gln Val Phe Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Val Glu
500 505 510
Tyr Val His Gln Lys Trp Asn Ser Tyr Ile Thr Gln Tyr Ser Thr Gly
515 520 525
Gln Cys Thr Val Glu Met Val Trp Glu Leu Arg Lys Glu Asn Ser Lys
530 535 540
Arg Trp Asn Pro Glu Ile Gln Phe Thr Ser Asn Phe Ser Asp Arg Thr
545 550 555 560
Ser Ile Met Phe Ala Pro Asn Glu Thr Gly Gly Tyr Ile Glu Asp Arg
565 570 575
Leu Ile Gly Thr Arg Tyr Leu Thr Gln Asn Leu
580 585
<210> 4
<211> 20
<212> DNA
<213> 人工序列
<220>
<223> DEV-F引物
<400> 4
atgggttcca gatggaaggc 20
<210> 5
<211> 20
<212> DNA
<213> 人工序列
<220>
<223> DEV-R引物
<400> 5
ctatcgtcgg ccatggtgta 20

Claims (14)

1.一种鸭疱疹病毒1型(Anatid herpesvirus 1)病毒株，所述病毒株属于疱疹病毒科、α疱疹病毒亚科和马立克病毒属，其中所述病毒株具有SEQ ID NO:1所示的基因组序列。
2.根据权利要求1所述的病毒株，其中所述病毒株的基因组包含SEQ ID NO:2所示的UL1序列，其中所述病毒株为具有保藏号CGMCC 45056的DEV SD70。
3.根据权利要求2所述的病毒株，其中相对于病毒株DEV SD04的160663bp的基因组序列，所述病毒株DEV SD70的154685bp的基因组序列具有以下突变：
2311-5373位(3063nt)核苷酸的缺失，
146179-148673位(2495nt)核苷酸替换为388nt的编码框SORFx，
123708-123907位(200nt)核苷酸的缺失，
126731-127138位(408nt)核苷酸的缺失，
157484-157891位(408nt)核苷酸的缺失，
131060-131061位(104nt)核苷酸的***，和
153561-153562位(104nt)核苷酸的***。
4.一种用于预防或治疗禽病毒感染症的疫苗，包含治疗有效量的保藏编号为CGMCC45056的病毒株DEV SD70，其中所述禽病毒感染症是鸭瘟病毒引起的疾病，进一步地，所述禽病毒感染症为鸭病毒性肠炎，
其中所述病毒株DEV SD70为活病毒株、减毒活病毒株或灭活病毒株，所述疫苗中的所述病毒株DEV SD70以1×102TCID50/ml或TCID50/g至1×108TCID50/ml或TCID50/g的浓度存在。
5.根据权利要求4所述的疫苗，其中所述疫苗中的所述病毒株DEV SD70以5×104TCID50/ml或TCID50/g至2×106TCID50/ml或TCID50/g的浓度存在。
6.根据权利要求4所述的疫苗，其中所述疫苗还包括佐剂。
7.保藏编号为CGMCC 45056的病毒株DEV SD70在制备用于预防或治疗鸭瘟病毒感染症的药物中的用途，其中受试禽包括鸡、鸭、鹅、雁、鸽、鹌鹑或鸵鸟；其中所述鸭瘟病毒引起的疾病为病毒性肠炎，
对于每一受试禽，以1×102TCID50至1×108TCID50病毒株DEV SD70/次的剂量施用疫苗。
8.根据权利要求7所述的用途，其中对于每一受试禽，以5×104TCID50至2×106TCID50病毒株DEV SD70/次的剂量施用所述疫苗。
9.根据权利要求7所述的用途，其中，以间隔60天施用2次的频率向所述受试禽施用所述疫苗。
10.根据权利要求8或9所述的用途，其中将所述疫苗经由皮下、皮内、肌内、静脉注射、口服或吸入的途径，
其中向所述受试禽施用所述疫苗至少1次。
11.一种重组病毒，所述重组病毒是基于根据权利要求1至3中任一项所述的病毒株的工程化病毒，
其中所述重组病毒包含编码水禽病毒的保护性抗原片段的外源基因，所述外源基因位于所述重组病毒中对应于所述病毒株的UL27至UL26之间非编码区的区域，
其中所述保护性抗原片段为小鹅瘟病毒VP2蛋白、鸭圆环病毒Cap蛋白、鹅星状病毒Cap蛋白、禽流感病毒HA蛋白、禽流感病毒NA蛋白、坦布苏病毒E蛋白和坦布苏病毒prM蛋白，
其中所述重组病毒用于预防或治疗鸡瘟病、鸭瘟病和鹅瘟病中的至少一种。
12.根据权利要求11所述的重组病毒，其中，所述保护性抗原片段是具有由SEQ ID No:3限定的序列的小鹅瘟病毒VP2蛋白。
13.根据权利要求11所述的重组病毒，其中所述重组病毒包含编码CMV启动子的核酸、编码水禽病毒的保护性抗原片段的外源基因、和编码bGH poly腺苷酸化信号的核酸。
14.一种药物组合物，包含根据权利要求11-13任一所述的重组病毒和药学上可接受的载体。
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