CN114470113A - Traditional Chinese medicine composition for relieving glyphosate herbicide poisoning and preparation method thereof - Google Patents
Traditional Chinese medicine composition for relieving glyphosate herbicide poisoning and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for relieving glyphosate herbicide poisoning, which comprises the following raw material medicines: folium Mori, Scutellariae radix, semen Phaseoli Radiati, radix scrophulariae, Ganoderma, Coicis semen, ramulus Mori, Coptidis rhizoma, herba Andrographitis, folium Isatidis, Glycyrrhrizae radix, fructus forsythiae, radix Puerariae, radix Isatidis, herba plantaginis, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, Atractylodis rhizoma, radix Paeoniae Rubra, flos Lonicerae, pericarpium Citri Tangerinae, flos Chrysanthemi, herba Agastaches, bupleuri radix, fructus Aurantii Immaturus, rhizoma Smilacis Glabrae, cortex Hibisci, and Eucommiae cortex; the traditional Chinese medicine provided by the invention has the main effects of clearing away heat and toxic materials, eliminating dampness and inducing resuscitation, and is used for treating pesticide poisoning caused by glyphosate herbicide poisoning; the physical process does not generate chemical change, can increase the solubility and dissolution speed of the volatile oil, can improve the stability of the volatile oil, enables the volatile oil to be powdered, reduces the volatility of the volatile oil and improves the utilization rate of the volatile oil; the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning has the characteristics of simple preparation method, high bioavailability, controllable quality, good stability, high precision and easiness in mastering.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine and pharmacy, and particularly relates to a traditional Chinese medicine composition for relieving glyphosate herbicide poisoning and a preparation method thereof.
Background
Glyphosate is a non-selective and residue-free biocidal herbicide, is very effective on perennial rooting weeds, and is widely used in rubber, mulberry, tea, orchards and sugarcane fields. Mainly inhibits enol pyruvyl shikimic acid phosphate synthetase in plants, thereby inhibiting the conversion of shikimic acid to phenylalanine, tyrosine and tryptophan, interfering protein synthesis and leading to plant death. Glyphosate is absorbed by stems and leaves and then transferred to various parts of plants, and can prevent and kill monocotyledons, dicotyledons, annual and perennial plants, herbaceous plants, shrubs and other plants of more than 40 families. After entering the soil, the glyphosate is combined with metal ions such as iron, aluminum and the like quickly to lose activity.
Preventing and removing weeds in apple gardens, peach gardens, vineyards, pear gardens, tea gardens, mulberry gardens and farmland fallow fields, and killing annual weeds such as barnyard grass, amur foxtail, goosegrass herb, large crabgrass, xanthium sibiricum, chenopodium album, chickweed, cleavers and the like. Glyphosate can kill green tissue only after contacting the tissue. The dosages of the herbicide are different due to different sensitivities of various weeds to glyphosate.
At present, the first four pesticides used in China are organophosphorus, organochlorine, chlordimeform and carbamates, and particularly, organophosphorus poisoning is the most common, so that organophosphorus pesticide poisoning is the most common in clinical pesticide poisoning. The high-toxicity organophosphorus pesticide can be poisoned by contacting a small amount of the pesticide, and the low-toxicity organophosphorus pesticide can be damaged by entering a large amount of the pesticide. The toxic amount and the lethal amount of the human body to the organic phosphorus are greatly different, and the toxic symptoms are serious and acute when the toxic symptoms are absorbed by the respiratory tract or the skin with more common concentration from the digestive tract.
The time and severity of the symptoms of organophosphorus pesticide poisoning are closely related to the entering route, pesticide property, entering amount and absorption amount, the health condition of human body, and the like, generally acute poisoning usually occurs within 12 hours, if the organophosphorus pesticide is inhaled, high-concentration or virulent organophosphorus pesticide can be orally taken within several to ten minutes to death, the symptoms occur, the death and death occur, the onset time of skin contact poisoning is slow, but the serious symptoms after absorption can be shown, the early stage or mild symptoms of the organophosphorus pesticide poisoning can cause dizziness, headache, nausea, vomit, salivation, hyperhidrosis, blurred vision, weakness and the like, the serious patients have miosis, muscle tremor, lacrimation, the increase of bronchial secretion, the dryness of the lung, the wet rale and wheeze, abdominal pain, diarrhea, consciousness absentmindedness, the tradition, bradycardia, fever, chill and the like besides the symptoms, severe cases often have tachycardia, atrioventricular block, arrhythmia such as atrial fibrillation, blood pressure rise or fall, cyanosis, dyspnea, oral and nasal foam even with blood (pulmonary edema), convulsion, coma, macrosomia, urinary incontinence or urine retention, quadriplegia, reflex disappearance and the like, can die due to respiratory paralysis or accompanying circulatory exhaustion, inhalation poisoning patients have early respiratory tract and eye symptoms, gastrointestinal tract symptoms often occur first in oral poisoning, skin contact poisoning is first shown by local sweating and adjacent muscle fiber contraction, erythema-like change is mostly occurred at the contact part of dichlorvos and skin, the patient gradually becomes blister, and the patient has itching and burning sensation.
The Chinese patent publication No. CN104127749A discloses a traditional Chinese medicine for treating organophosphorus pesticide poisoning and a preparation method thereof, wherein the traditional Chinese medicine comprises the following raw material medicines: mulberry leaf, reed rhizome, bamboo leaf, scutellaria baicalensis, coptis chinensis, gentian, meadowrue root and rhizome, andrographis paniculata, folium isatidis, rhizoma paridis, bistort rhizome, Chinese olive, tinospora root, Chinese lobelia herb, oroxylum indicum, mung bean, radix rehmanniae, figwort root, buffalo horn, lilac daphne flower bud, rheum officinale, aloe, mulberry twig, herba siegesbeckiae, coix seed, shepherd's purse, cinnamon, dutchmanspipe root, buckeye seed, areca peel, ternate buttercup root, lucid ganoderma, nacre mother of pearl, antelope horn, bezoar, uncaria, earthworm, centipede and borneol.
However, in the existing treatment of glyphosate herbicide poisoning, the problems that the performance of traditional Chinese medicine relief treatment medicines is not ideal enough and the optimal treatment time is easy to delay exist, and meanwhile, the preparation method is complex and tedious.
Therefore, the invention provides a traditional Chinese medicine composition for relieving glyphosate herbicide poisoning and a preparation method thereof.
Disclosure of Invention
In order to solve the technical problems, the invention provides a traditional Chinese medicine composition for relieving glyphosate herbicide poisoning, which comprises the following raw material medicines: mulberry leaf, scutellaria baicalensis, mung bean, figwort root, lucid ganoderma, coix seed, mulberry twig, coptis chinensis, common andrographis herb, indigowoad leaf, liquorice, fructus forsythiae, kudzuvine root, isatis root, plantain herb, szechuan lovage rhizome, Chinese angelica, largehead atractylodes rhizome, red paeony root, honeysuckle flower, tangerine peel, chrysanthemum, wrinkled gianthyssop herb, radix bupleuri, immature bitter orange, glabrous greenbrier rhizome, hibiscus syriacus and eucommia bark.
Preferably, the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning comprises the following raw material medicines in parts by weight: 10-20 parts of mulberry leaf, 12-39 parts of scutellaria baicalensis, 10-15 parts of mung bean, 2-10 parts of radix scrophulariae, 5-10 parts of lucid ganoderma, 10-20 parts of coix seed, 10-40 parts of mulberry twig, 20-35 parts of coptis chinensis, 5-10 parts of common andrographis herb, 8-19 parts of folium isatidis, 20-50 parts of liquorice, 1-8 parts of fructus forsythiae, 3-30 parts of radix puerariae, 15-30 parts of isatis root, 6-36 parts of plantain herb, 5-25 parts of ligusticum wallichii, 5-27 parts of angelica sinensis, 12-31 parts of bighead atractylodes rhizome, 8-39 parts of red peony root, 11-29 parts of honeysuckle flower, 15-40 parts of dried orange peel, 8-50 parts of chrysanthemum, 10-30 parts of agastache rugosus, 9-19 parts of radix bupleuri, 6-29 parts of immature bitter orange, 8-38 parts of glabrous greenbrier rhizome, 10-30 parts of hibiscus syriacus and 2-12 parts of eucommia ulmoides.
Preferably, the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning is prepared from the following raw material medicines in parts by weight: 10 parts of mulberry leaf, 15 parts of scutellaria baicalensis, 11 parts of mung bean, 8 parts of figwort root, 5 parts of lucid ganoderma, 10 parts of coix seed, 10 parts of mulberry twig, 20 parts of coptis chinensis, 5 parts of common andrographis herb, 8 parts of indigowoad leaf, 25 parts of liquorice, 8 parts of weeping forsythia capsule, 15 parts of kudzuvine root, 20 parts of indigowoad root, 21 parts of plantain herb, 22 parts of szechuan lovage rhizome, 16 parts of Chinese angelica, 18 parts of largehead atractylodes rhizome, 21 parts of red paeony root, 21 parts of honeysuckle flower, 25 parts of tangerine peel, 44 parts of chrysanthemum, 21 parts of wrinkled gianthyssop herb, 14 parts of Chinese thorowax root, 19 parts of immature bitter orange, 25 parts of glabrous greenbrier rhizome, 24 parts of hibiscus and 8 parts of eucommia ulmoides.
The preparation method of the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning specifically comprises the following steps:
the method comprises the following steps: cleaning and screening the traditional Chinese medicine raw materials: screening the traditional Chinese medicine raw materials of the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning, and cleaning and removing impurities; the purpose of cleaning is to extract medicinal parts of medicinal materials, remove non-medicinal parts and impurities, make the medicinal materials reach certain purity and standard, and simultaneously facilitate cutting, processing and preparation.
Step two: processing and crushing the traditional Chinese medicine raw materials: drying each raw material medicine at 45-55 deg.C for 5-8 hr, pulverizing, sieving with 40-100 mesh sieve, and weighing the pulverized materials.
Step three: mixing the traditional Chinese medicine raw materials: mixing the pulverized materials in the step two, adding water with 5-10 times of the total mass, soaking for 30-60min, and extracting with ultrasonic extractor for 30-45min for 3-5 times.
Step four: extracting the traditional Chinese medicine preparation: extracting volatile oil from the mixture in the third step by adopting a steam distillation method, collecting primary distillate, carrying out secondary steam distillation on the primary distillate to obtain refined distillate, extracting with diethyl ether, drying with anhydrous sodium sulfate, concentrating under reduced pressure to obtain volatile oil, reserving dregs and decoction for later use, clathrating the volatile oil with beta-cyclodextrin, concentrating under reduced pressure and drying the water extract to obtain a liquid extract.
Step five: preparing the traditional Chinese medicine granules: drying the extract in the fourth step to prepare inclusion particles, thereby obtaining the traditional Chinese medicine composition.
Step six: finishing the traditional Chinese medicine tablets: and D, pretreating the traditional Chinese medicine composition in the step five before tablet compression, and filtering, screening, classifying and humidifying the granules.
Step seven: tabletting and coating of the traditional Chinese medicine therapeutic tablet: tabletting the whole granulate of the Chinese medicinal composition and preheating the tablets to be coated containing at least 50% of a water-absorbing polymer under conditions which result in no complete loss of the tablet's ability to expand under heat, and then maintaining the tablets under conditions which allow them to expand completely while or after the coating fluid is applied, thereby restoring the surface state of the tablets.
Step eight: and (3) packaging the finished product by quality inspection: and (5) performing quality inspection on the coated traditional Chinese medicine tablets.
Preferably, in the fourth step, the distillation liquid is filtered through a 150-mesh filter of 120-.
Preferably, in the fifth step, the drying temperature is controlled to be 45-55 ℃, the drying is carried out after the temperature is naturally reduced to about 25 ℃, and then the inclusion particles are prepared by sieving the particles through a 50-80 mesh sieve.
Preferably, in the sixth step, the finishing humidity of the whole grains of the traditional Chinese medicine composition is set to be between 20% and 30%.
Wherein, the pharmacology of the raw material medicines is as follows:
mulberry leaf: bitter, sweet and cold in nature; it enters lung and liver meridians. Benefiting the five internal organs, dredging joints and descending qi; dispelling wind pain and sweating, and removing blood stasis; snake, worm and centipede bite, dispel wind-heat, release exterior and clear heat, nourish yin and promote the production of body fluid.
Scutellaria baicalensis: bitter and cold in nature; it enters lung, gallbladder, spleen, large intestine and small intestine meridians. Has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing toxic materials, stopping bleeding, preventing miscarriage, and lowering blood pressure. Can be used for treating chest distress, nausea, damp-heat, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.
Mung beans are sweet in taste and cold in nature, enter heart and stomach meridians, and have the effects of clearing heat, detoxifying, tonifying primordial qi, regulating five internal organs and the like.
Figwort root: sweet, bitter, salty and slightly cold in nature; it enters lung, stomach and kidney meridians. Has the effects of clearing heat and cooling blood, purging fire and removing toxicity, and nourishing yin, and is mainly used for treating heat of warm diseases, nutrient and blood, fever, polydipsia, crimson tongue, macula, hectic fever due to yin deficiency, dysphoria, body fluid deficiency and constipation, dryness and dim eyesight, sore throat, scrofula and subcutaneous nodule, superficial infection and sore toxicity and other symptoms.
Ganoderma lucidum: sweet and mild; it enters five meridians of heart, liver, spleen, lung and kidney. It can be used for treating consumptive disease, cough, asthma, insomnia, dyspepsia, and malignant tumor.
Coix seed: cool in nature, sweet and bland in flavor; it enters spleen, stomach and lung meridians. To invigorate the spleen, remove dampness, remove arthralgia, check diarrhea, clear heat and expel thick. Can be used for treating edema, loempe, dysuresia, damp arthralgia, spasm, diarrhea due to spleen deficiency, pulmonary abscess, and intestinal abscess; flat warts.
Mulberry twig: sweet, mild and nontoxic; it enters liver meridian. Dispel wind-damp and benefit joints. Can be used for treating soreness and numbness of shoulder, arm, and joint.
Coptis chinensis: bitter, cold and nontoxic; it enters heart, spleen, stomach, liver, gallbladder and large intestine meridians. Has the functions of clearing heat, drying dampness, purging fire and removing toxicity. Can be used for treating damp-heat fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, coma, heart and stomach fire purging, emesis, and distention, and can be used for treating vexation, insomnia, blood heat, hematemesis, conjunctival congestion, toothache, thirst, carbuncle, swelling, and furuncle due to excessive heart fire; it is used externally to treat eczema, eczema and purulent ear canal. Huang Lian (Chinese goldthread) processed with wine is good at clearing heat in upper energizer.
Andrographis paniculata: bitter and cold; it enters heart, lung, large intestine and bladder meridians. Clear heat and remove toxicity, cool blood and relieve swelling. Can be used for treating common cold, fever, sore throat, aphtha, cough, diarrhea, dysentery, stranguria, carbuncle, suppurative sore, and snake bite.
Folium isatidis: bitter and cold; it enters liver, heart and stomach meridians. Dysentery due to toxic heat, jaundice, sore throat, erysipelas. Clear heat, remove toxicity, cool blood and stop bleeding. It can be used for treating epidemic febrile disease, excessive heat, polydipsia, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, hematemesis, epistaxis, jaundice, dysentery, pharyngitis, aphtha, carbuncle, and pyogenic infections.
The liquorice has sweet taste and neutral nature, and has the effects of nourishing the stomach, enriching the blood, tonifying qi and strengthening the middle warmer, relieving spasm and pain, moistening the lung to arrest cough, purging fire, detoxifying, harmonizing the drugs and the like, and the liquorice enters spleen channels, stomach channels and lung channels. The glycyrrhiza extract and glycyrrhizin have certain detoxification capacity to drug poisoning, food poisoning and in-vivo metabolite poisoning, the effective component of the detoxification function is glycyrrhizin, the detoxification mechanism is that glycyrrhizin has adsorption effect to toxicants, glycyrrhizin hydrolysate glucuronic acid can combine with toxicants, and glycyrrhizin has adrenocortical hormone-like effect and enhances the detoxification capacity of liver.
Fructus forsythiae is bitter in taste and slightly cold in nature, enters heart, lung and small intestine channels, and has the effects of clearing heat, detoxifying, dissipating stagnation, dispelling wind, dissipating heat and the like.
The kudzu root is sweet in taste and cool in nature, enters lung and stomach channels, and has the effects of clearing heat, reducing pathogenic fire, detoxifying, promoting urination, invigorating stomach and the like.
The isatis root is bitter in taste and cold in nature, enters liver and stomach channels, and has the effects of clearing heat, detoxifying, benefiting gallbladder, promoting urination, treating stranguria, invigorating stomach and the like.
The plantain herb is sweet in taste and slightly cold in nature, enters lung, liver, kidney and bladder channels, and has the effects of clearing heat, detoxifying, promoting urination, treating stranguria, excreting dampness, stopping diarrhea and the like.
Ligusticum wallichii: pungent and warm herbs enter liver and gallbladder meridians. Xiren is that Chuan Xiong is a qi-flowing medicine in blood, but it has the functions of dispersing acrid, relieving depression, dredging and relieving pain.
Chinese angelica: sweet, pungent and warm, enter liver, heart and spleen meridians. Has effects of replenishing blood, promoting blood circulation, moistening dryness, and smoothing intestine. It can be used for treating blood deficiency, abdominal mass, asthenia cold, abdominal pain, flaccidity arthralgia, numbness of skin, intestinal dryness, constipation, and dysentery with severe afterdiarrhea.
White atractylodes rhizome: bitter, sweet and warm, entering spleen and stomach meridians. Invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, arresting sweating, and preventing miscarriage. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm and fluid retention, dizziness, palpitation, edema, and spontaneous perspiration.
Red peony root: bitter taste and slightly cold nature, and can be used for treating heat entering nutrient-blood, warm toxin and macula, hematemesis and epistaxis, conjunctival congestion and swelling pain, liver depression and hypochondriac pain, amenorrhea and dysmenorrhea, addiction to abdominal pain, traumatic injury, carbuncle, swelling, and pyocutaneous disease.
Honeysuckle flower: clear heat and remove toxicity, stir-baked to charcoal to cool blood and stop bleeding.
Dried orange peel: bitter and warm taste, spleen, stomach and lung channels, has effects of clearing heat, removing toxic substance, promoting urination, treating stranguria, invigorating spleen, regulating middle warmer, regulating qi-flowing, and is suitable for spleen and stomach weakness, diet reduction, dyspepsia, diarrhea, etc.
Chrysanthemum: bitter and slightly warm, enters lung and liver meridians, and has the effects of dispelling wind, clearing heat, removing toxicity, promoting urination, treating stranguria, strengthening spleen, harmonizing stomach and the like.
Agastache rugosus: has pungent taste and mild property, and has effects of invigorating spleen, stomach and lung channels, clearing heat, removing toxic substance, promoting urination, treating stranguria, invigorating spleen, and nourishing stomach.
Bupleurum root: it is a commonly used exterior syndrome relieving herb. Is also called as Diwu, potherb mustard, mushroom grass and firewood, is bitter in nature and taste, slightly cold, and enters liver and gallbladder meridians.
Immature bitter orange: bitter, pungent and sour, and slightly cold, and can be used for stagnation, fullness and distending pain, diarrhea and dysentery with tenesmus, constipation, phlegm stagnation and qi obstruction, thoracic obstruction, accumulation of phlegm in chest, and prolapse of viscera.
Glabrous greenbrier rhizome: sweet, bland and neutral, enter liver and stomach meridians. Has effects in removing toxic materials, eliminating dampness, and smoothing joint movement.
And (3) yellow shrubalthea: bitter, pungent and cold herbs enter lung meridian. Clearing heat, relieving cough, removing toxic substance and relieving swelling, and can be used for treating affection of exogenous wind-heat, cough, phlegm-fire stagnation, yellow and thick phlegm, cough due to lung heat, carbuncle, sore, pyogenic infections, and bronchitis.
Eucommia ulmoides: sweet and warm in nature, they enter liver and kidney meridians. Has effects in nourishing liver and kidney, treating soreness of waist and back, and weakness of feet and knees, regulating immune system, endocrine system, central nervous system, circulatory system and urinary system, and can stimulate pituitary-adrenal cortex system and enhance adrenal cortex function.
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine provided by the invention has the main effects of clearing away heat and toxic materials, eliminating dampness and inducing resuscitation, and is used for treating pesticide poisoning caused by glyphosate herbicide poisoning; the traditional Chinese medicine preparation utilizes the traditional Chinese medicine theory, attaches importance to the holism concept, enhances the disease pathogen defense capability of the organism, and strengthens the healthy qi, has stronger targeting property through dialectical treatment, eliminates toxin, treats both principal and secondary aspect of disease, is safe and effective, has less adverse reaction, shorter treatment course, convenient administration, is easy to be accepted by patients, and improves the cure rate;
the volatile oil is extracted when the traditional Chinese medicine preparation is prepared, so that the curative effect of the traditional Chinese medicine preparation can be effectively guaranteed, the volatile oil is included by beta-cyclodextrin to prepare particles, the physical process is not subjected to chemical change, the solubility and the dissolution speed of the volatile oil can be increased, the stability of the volatile oil can be improved, the volatile oil is powdered, the volatility of the volatile oil is reduced, and the utilization rate of the volatile oil is improved;
the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning has the advantages of simple preparation method, high bioavailability, controllable quality, good stability, low equipment requirement and easiness for large-scale preparation and production, and has the characteristics of simplicity, stability, high precision, good reproducibility and easiness for mastering.
Drawings
FIG. 1 is a flow chart of a method of preparation of the glyphosate herbicide poisoning treatment of the present invention.
Detailed Description
The invention is further described below with reference to the accompanying drawings:
in the figure:
example 1:
the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning comprises the following raw material medicines: folium mori, scutellaria baicalensis, mung beans, radix scrophulariae, lucid ganoderma, semen coicis, mulberry twigs, coptis chinensis, andrographis paniculata, folium isatidis, liquorice, fructus forsythiae, the root of kudzu vine, radix isatidis, plantain, ligusticum wallichii, angelica sinensis, rhizoma atractylodis macrocephalae, the root of common peony, honeysuckle, pericarpium citri reticulatae, chrysanthemum, agastache rugosus, radix bupleuri, immature bitter orange, rhizoma smilacis glabrae, hibiscus syriacus and eucommia ulmoides.
In the above embodiment, specifically, the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning may preferably include the following raw material medicines in parts by weight: 10-20 parts of mulberry leaf, 12-39 parts of scutellaria baicalensis, 10-15 parts of mung bean, 2-10 parts of radix scrophulariae, 5-10 parts of lucid ganoderma, 10-20 parts of coix seed, 10-40 parts of mulberry twig, 20-35 parts of coptis chinensis, 5-10 parts of common andrographis herb, 8-19 parts of folium isatidis, 20-50 parts of liquorice, 1-8 parts of fructus forsythiae, 3-30 parts of radix puerariae, 15-30 parts of isatis root, 6-36 parts of plantain herb, 5-25 parts of ligusticum wallichii, 5-27 parts of angelica sinensis, 12-31 parts of bighead atractylodes rhizome, 8-39 parts of red peony root, 11-29 parts of honeysuckle flower, 15-40 parts of dried orange peel, 8-50 parts of chrysanthemum, 10-30 parts of agastache rugosus, 9-19 parts of radix bupleuri, 6-29 parts of immature bitter orange, 8-38 parts of glabrous greenbrier rhizome, 10-30 parts of hibiscus syriacus and 2-12 parts of eucommia ulmoides.
In the above embodiment, specifically, the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning is prepared from the following raw material medicines in parts by weight: 10 parts of mulberry leaf, 15 parts of scutellaria baicalensis, 11 parts of mung bean, 8 parts of figwort root, 5 parts of lucid ganoderma, 10 parts of coix seed, 10 parts of mulberry twig, 20 parts of coptis chinensis, 5 parts of common andrographis herb, 8 parts of indigowoad leaf, 25 parts of liquorice, 8 parts of weeping forsythia capsule, 15 parts of kudzuvine root, 20 parts of indigowoad root, 21 parts of plantain herb, 22 parts of szechuan lovage rhizome, 16 parts of Chinese angelica, 18 parts of largehead atractylodes rhizome, 21 parts of red paeony root, 21 parts of honeysuckle flower, 25 parts of tangerine peel, 44 parts of chrysanthemum, 21 parts of wrinkled gianthyssop herb, 14 parts of Chinese thorowax root, 19 parts of immature bitter orange, 25 parts of glabrous greenbrier rhizome, 24 parts of hibiscus and 8 parts of eucommia ulmoides. As shown in fig. 1, the preparation method of the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning specifically comprises the following steps:
s101: cleaning and screening the traditional Chinese medicine raw materials: screening the traditional Chinese medicine raw materials of the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning, and cleaning and removing impurities; the purpose of cleaning is to extract medicinal parts of medicinal materials, remove non-medicinal parts and impurities, make the medicinal materials reach certain purity and standard, and simultaneously facilitate cutting, processing and preparation.
S102: processing and crushing the traditional Chinese medicine raw materials: drying each raw material medicine at 45-55 deg.C for 5-8 hr, pulverizing, sieving with 40-100 mesh sieve, and weighing the pulverized materials.
S103: mixing the traditional Chinese medicine raw materials: mixing the pulverized materials in the step two, adding water with 5-10 times of the total mass, soaking for 30-60min, and extracting with ultrasonic extractor for 30-45min for 3-5 times.
S104: extracting the traditional Chinese medicine preparation: extracting volatile oil from the mixture in the third step by adopting a steam distillation method, collecting primary distillate, carrying out secondary steam distillation on the primary distillate to obtain refined distillate, extracting with diethyl ether, drying with anhydrous sodium sulfate, concentrating under reduced pressure to obtain volatile oil, reserving dregs and decoction for later use, clathrating the volatile oil with beta-cyclodextrin, concentrating under reduced pressure and drying the water extract to obtain a liquid extract.
S105: preparing the traditional Chinese medicine granules: drying the extract in the fourth step to prepare inclusion particles, thereby obtaining the traditional Chinese medicine composition.
S106: and (3) finishing the traditional Chinese medicine tablets: and D, pretreating the traditional Chinese medicine composition in the step five before tablet compression, and filtering, screening, classifying and humidifying the granules.
S107: tabletting and coating of the traditional Chinese medicine therapeutic tablet: tabletting the whole granulate of the Chinese medicinal composition and preheating the tablets to be coated containing at least 50% of a water-absorbing polymer under conditions which result in no complete loss of the tablet's ability to expand under heat, and then maintaining the tablets under conditions which allow them to expand completely while or after the coating fluid is applied, thereby restoring the surface state of the tablets.
S108: and (3) packaging the finished product by quality inspection: and (5) performing quality inspection on the coated traditional Chinese medicine tablets.
In the above embodiment, specifically, in S104, the distillation liquid is filtered through 120-.
In the above embodiment, specifically, in S105, the drying temperature is controlled to 45 to 55 ℃, the drying is performed, the temperature is naturally reduced to about 25 ℃ of the room temperature, and then the inclusion particles are prepared by sieving the particles with a 50 to 80 mesh sieve.
In the above embodiment, specifically, in S106, the finishing humidity of the traditional Chinese medicine composition is set to be between 20% and 30%.
The clinical curative effect is summarized as follows:
1. general data: the traditional Chinese medicine preparation is used for relieving 50 patients suffering from glyphosate herbicide poisoning, wherein 26 male patients and 24 female patients are aged 16-63 years, and the disease course is 15 days to three years.
2. The usage and dosage are as follows: in clinical application, 5g of the Chinese medicinal preparation prepared in the embodiment 1 is taken in the morning, the middle and the evening each day, two weeks are taken as a treatment course, 2-3 treatment courses are continuously taken according to the state of an illness, and uncooked, cold, spicy, pungent and greasy food is forbidden during the taking period.
3. Diagnostic criteria:
(1) there is a history of taking the medicine by mistake, taking the medicine by oneself, and contacting with pesticide.
(2) There are typical symptoms of pesticide poisoning: asthenia, tinnitus, amnesia, insomnia, dreaminess, dry throat and mouth, dysphoria with smothery sensation in chest, listlessness, anorexia, nausea, emesis, diarrhea, etc.
4. The curative effect standard is as follows:
the curative effect standard is as follows: made according to the diagnosis and treatment standards and prescription selection of the traditional Chinese medicine.
(1) And (3) curing: symptom disappearance, normal mood, normal diet and self-care life;
(2) the effect is shown: the symptoms disappear, the mood is normal, and the life can be basically self-care;
(3) the method has the following advantages: the symptoms are relieved, the mood is basically stable, the life can be basically self-care, and the medicine maintenance is frequently needed;
(4) and (4) invalidation: no change is caused by treatment.
5. The treatment effect is as follows: in the clinical observation case, the medicine is taken for 2-3 courses of treatment, 5 cases are cured, 30 cases are obviously effective, 12 cases are effective, 3 cases are ineffective, the total effective rate is 94%, and no toxic or side effect occurs in the treatment period.
6. Typical cases
Case 1: if a certain plum is in 34 years old and a woman eats the glyphosate herbicide by mistake, the patient is rescued and treated in an emergency department, and the patient is transferred to a medical ward for continuous treatment after the condition of the patient is stable, after the traditional Chinese medicine preparation disclosed by the embodiment 1 of the invention is taken for two treatment courses, symptoms such as hypodynamia, insomnia, dreaminess, dyspnea, restlessness and the like are obviously relieved, and after the traditional Chinese medicine preparation is taken for three treatment courses, an effective relieving effect is obtained.
Case 2:
in 45 years old and in Wangzhi, the glyphosate herbicide is contacted for a long time, clinical symptoms such as lassitude, weakness, no appetite, nausea, vomiting and the like appear, and the symptoms are obviously relieved after a plurality of treatment are ineffective, and the Chinese medicinal preparation disclosed in the embodiment 1 of the invention is taken for two courses of treatment, and the Chinese medicinal preparation is cured after the Chinese medicinal preparation is taken for two courses of treatment.
Case 3:
zhangzhi, male, 55 years old, because of spraying and contacting the glyphosate herbicide to protect the assembly badly, has poisoned the clinical symptom, through many treatment ineffective, after taking two courses of treatment of Chinese medicinal preparation described in embodiment 1 of this invention, the symptom is obviously relieved, fully recover after continuing to take a course of treatment.
The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts of the present invention. The foregoing is only a preferred embodiment of the present invention, and it should be noted that there are objectively infinite specific structures due to the limited character expressions, and it will be apparent to those skilled in the art that a plurality of modifications, decorations or changes may be made without departing from the principle of the present invention, and the technical features described above may be combined in a suitable manner; such modifications, variations, combinations, or adaptations of the invention using its spirit and scope, as defined by the claims, may be directed to other uses and embodiments.
Claims (7)
1. The traditional Chinese medicine composition for relieving glyphosate herbicide poisoning is characterized by comprising the following raw material medicines: mulberry leaf, scutellaria baicalensis, mung bean, figwort root, lucid ganoderma, coix seed, mulberry twig, coptis chinensis, common andrographis herb, indigowoad leaf, liquorice, fructus forsythiae, kudzuvine root, isatis root, plantain herb, szechuan lovage rhizome, Chinese angelica, largehead atractylodes rhizome, red paeony root, honeysuckle flower, tangerine peel, chrysanthemum, wrinkled gianthyssop herb, radix bupleuri, immature bitter orange, glabrous greenbrier rhizome, hibiscus syriacus and eucommia bark.
2. The traditional Chinese medicine composition for relieving glyphosate herbicide poisoning of claim 2, wherein the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning preferably comprises the following raw medicinal materials in parts by weight: 10-20 parts of mulberry leaf, 12-39 parts of scutellaria baicalensis, 10-15 parts of mung bean, 2-10 parts of radix scrophulariae, 5-10 parts of lucid ganoderma, 10-20 parts of coix seed, 10-40 parts of mulberry twig, 20-35 parts of coptis chinensis, 5-10 parts of common andrographis herb, 8-19 parts of folium isatidis, 20-50 parts of liquorice, 1-8 parts of fructus forsythiae, 3-30 parts of radix puerariae, 15-30 parts of isatis root, 6-36 parts of plantain herb, 5-25 parts of ligusticum wallichii, 5-27 parts of angelica sinensis, 12-31 parts of bighead atractylodes rhizome, 8-39 parts of red peony root, 11-29 parts of honeysuckle flower, 15-40 parts of dried orange peel, 8-50 parts of chrysanthemum, 10-30 parts of agastache rugosus, 9-19 parts of radix bupleuri, 6-29 parts of immature bitter orange, 8-38 parts of glabrous greenbrier rhizome, 10-30 parts of hibiscus syriacus and 2-12 parts of eucommia ulmoides.
3. The traditional Chinese medicine composition for relieving glyphosate herbicide poisoning of claim 2, which is prepared from the following raw materials in parts by weight: 10 parts of mulberry leaf, 15 parts of scutellaria baicalensis, 11 parts of mung bean, 8 parts of figwort root, 5 parts of lucid ganoderma, 10 parts of coix seed, 10 parts of mulberry twig, 20 parts of coptis chinensis, 5 parts of common andrographis herb, 8 parts of indigowoad leaf, 25 parts of liquorice, 8 parts of weeping forsythia capsule, 15 parts of kudzuvine root, 20 parts of indigowoad root, 21 parts of plantain herb, 22 parts of szechuan lovage rhizome, 16 parts of Chinese angelica, 18 parts of largehead atractylodes rhizome, 21 parts of red paeony root, 21 parts of honeysuckle flower, 25 parts of tangerine peel, 44 parts of chrysanthemum, 21 parts of wrinkled gianthyssop herb, 14 parts of Chinese thorowax root, 19 parts of immature bitter orange, 25 parts of glabrous greenbrier rhizome, 24 parts of hibiscus and 8 parts of eucommia ulmoides.
4. The traditional Chinese medicine composition for relieving glyphosate herbicide poisoning of claim 1, wherein the preparation method of the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning specifically comprises the following steps:
the method comprises the following steps: cleaning and screening the traditional Chinese medicine raw materials: screening the traditional Chinese medicine raw materials of the traditional Chinese medicine composition for relieving glyphosate herbicide poisoning, and cleaning and removing impurities; the purpose of cleaning is to extract medicinal parts of medicinal materials, remove non-medicinal parts and impurities, make the medicinal materials reach certain purity and standard, and simultaneously facilitate cutting, processing and preparation.
Step two: processing and crushing the traditional Chinese medicine raw materials: drying each raw material medicine at 45-55 deg.C for 5-8 hr, pulverizing, sieving with 40-100 mesh sieve, and weighing the pulverized materials.
Step three: mixing the traditional Chinese medicine raw materials: mixing the pulverized materials in the step two, adding water with 5-10 times of the total mass, soaking for 30-60min, and extracting with ultrasonic extractor for 30-45min for 3-5 times.
Step four: extracting the traditional Chinese medicine preparation: extracting volatile oil from the mixture in the third step by adopting a steam distillation method, collecting primary distillate, carrying out secondary steam distillation on the primary distillate to obtain refined distillate, extracting with diethyl ether, drying with anhydrous sodium sulfate, concentrating under reduced pressure to obtain volatile oil, reserving dregs and decoction for later use, clathrating the volatile oil with beta-cyclodextrin, concentrating under reduced pressure and drying the water extract to obtain a liquid extract.
Step five: preparing the traditional Chinese medicine granules: drying the extract in the fourth step to prepare inclusion particles, thereby obtaining the traditional Chinese medicine composition.
Step six: finishing the traditional Chinese medicine tablets: and D, pretreating the traditional Chinese medicine composition in the step five before tablet compression, and filtering, screening, classifying and humidifying the granules.
Step seven: tabletting and coating of the traditional Chinese medicine therapeutic tablet: tabletting the whole granulate of the Chinese medicinal composition and preheating the tablets to be coated containing at least 50% of a water-absorbing polymer under conditions which result in no complete loss of the tablet's ability to expand under heat, and then maintaining the tablets under conditions which allow them to expand completely while or after the coating fluid is applied, thereby restoring the surface state of the tablets.
Step eight: and (3) packaging the finished product by quality inspection: and (5) performing quality inspection on the coated traditional Chinese medicine tablets.
5. The method as claimed in claim 4, wherein in step four, the distillation liquid is filtered through a 150-mesh filter column with a cut-off molecular weight of 4500-98600, and the ultrafiltrate is concentrated under reduced pressure to an extract with a relative density of 1.0 ± 0.05 at 65 ℃.
6. The method for preparing a traditional Chinese medicine composition for alleviating glyphosate herbicide poisoning of claim 4, wherein in the fifth step, the drying temperature is controlled to be 45-55 ℃, the drying temperature is naturally reduced to about 25 ℃ at room temperature, and then the drying temperature is sieved by a 50-80 mesh sieve to prepare inclusion particles.
7. The method of claim 4, wherein in step six, the moisture content of the composition is between 20% and 30%.
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Citations (4)
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|---|---|---|---|---|
| CN104127749A (en) * | 2014-08-12 | 2014-11-05 | 李凡旺 | Traditional Chinese medicament for treating organic phosphorus pesticide poisoning and preparation method thereof |
| CN104547170A (en) * | 2014-12-25 | 2015-04-29 | 王从政 | Traditional Chinese medicine preparation for treating sequelae of pesticide intoxication |
| CN104825670A (en) * | 2015-05-25 | 2015-08-12 | 高树霞 | Traditional Chinese medicine preparation for treating gas poisoning sequelae |
| CN106729198A (en) * | 2016-11-14 | 2017-05-31 | 吉林大学 | It is a kind of to treat Chinese medicine preparation of pesticide poisoning sequela and preparation method thereof |
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- 2022-01-22 CN CN202210075701.6A patent/CN114470113A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127749A (en) * | 2014-08-12 | 2014-11-05 | 李凡旺 | Traditional Chinese medicament for treating organic phosphorus pesticide poisoning and preparation method thereof |
| CN104547170A (en) * | 2014-12-25 | 2015-04-29 | 王从政 | Traditional Chinese medicine preparation for treating sequelae of pesticide intoxication |
| CN104825670A (en) * | 2015-05-25 | 2015-08-12 | 高树霞 | Traditional Chinese medicine preparation for treating gas poisoning sequelae |
| CN106729198A (en) * | 2016-11-14 | 2017-05-31 | 吉林大学 | It is a kind of to treat Chinese medicine preparation of pesticide poisoning sequela and preparation method thereof |
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Application publication date: 20220513 |