CN114452238B - 具有安抚作用的宠物药浴香波及其制备方法 - Google Patents
具有安抚作用的宠物药浴香波及其制备方法 Download PDFInfo
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- CN114452238B CN114452238B CN202210017421.XA CN202210017421A CN114452238B CN 114452238 B CN114452238 B CN 114452238B CN 202210017421 A CN202210017421 A CN 202210017421A CN 114452238 B CN114452238 B CN 114452238B
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Abstract
本发明公开了一种具有安抚作用的宠物药浴香波及其制备方法,属于宠物保健品领域。其中,宠物药浴香波包括以下重量份的组分:抗真菌剂0.1~5份,抗细菌剂0.1~5份,安抚信息素0.1~10份,表面活性剂6~65份,增稠剂1~15份,螯合剂0.1~2份,助剂0~7份,水40~70份。本发明的宠物药浴香波既可预防和治疗猫常见的皮肤病,且可使得猫在安静状态下洗澡,减少猫的应激反应。
Description
技术领域
本发明涉及宠物保健品领域,尤其涉及一种具有安抚作用的宠物药浴香波及其制备方法。
背景技术
近些年,宠物行业迅速发展,以小型犬猫为主的宠物走进了广大中国家庭,并且宠物犬猫在人们心中占据着极其重要的地位,甚至发挥着其他事物不能代替的作用。
猫皮肤病是目前猫病临床中发病非常多的一类疾病,这类疾病一年四季均可发生、病因复杂,发病率较高、约占临床病例的25%,并且容易反复发作。皮肤病能引起猫皮肤瘙痒、脱毛、结痂和皮肤异常等症状,不仅严重危害宠物健康,而且给宠物主人带来很多困扰。其中猫真菌性皮肤病最为常见,且病程长、治疗难度大,容易反复,还可以导致动物与动物之间,动物与人之间的传染,是一种具有很强传染性的***共患皮肤病,严重威胁人体健康。
通过药浴香波来防治犬猫的皮肤病已越来越受到宠物主人的接受和认可,在洗澡时既达到清洁的目的又可防治皮肤疾病。但大多数猫都非常害怕洗澡,究其原因可能是猫天生是不喜欢水以及洗澡时***控造成的安全感缺失;大部分猫咪没办法接受这种不安全的情景,所以猫咪会挣扎抵触,甚至会有攻击行为!因此,给猫洗澡一直是宠物主人甚至是宠物美容从业者的难题。
发明内容
本发明所要解决的技术问题在于,提供一种具有安抚作用的宠物药浴香波,其可有效预防和治疗常见的猫皮肤病,且减少猫洗澡过程中的应激反应。
本发明还要解决的技术问题在于,提供一种上述的具有安抚作用的宠物药浴香波的制备方法。
为了解决上述技术问题,本发明提供了一种具有安抚作用的宠物药浴香波,其包括以下重量份的组分:抗真菌剂0.1~5份,抗细菌剂0.1~5份,安抚信息素0.1~10份,表面活性剂6~65份,增稠剂1~15份,螯合剂0.1~2份,助剂0~7份,水40~70份。
基于上述技术方案的具有安抚作用的宠物药浴香波,在宠物药浴香波中添加了抗真菌剂、抗细菌剂和安抚信息素,三种组分的联用既可预防和治疗猫常见的皮肤病,又可使得猫在安静状态下洗澡,减少猫的应激反应。
作为上述技术方案的改进,所述安抚信息素包括植物提取物;
所述植物提取物由安抚植物的茎、叶或果实通过液体信息素提取而得;
其中,所述安抚植物选用猫薄荷、木天蓼、银藤、鞑靼忍冬、缬草根、假荆芥、天竺葵、薰衣草、迷迭香中一种或多种;但不限于此。
所述液体信息素选用肉豆蔻酸甲酯、油酸甲酯、亚油酸甲酯、庚二酸二甲酯、壬二酸二甲酯、癸二酸二甲酯、正丁酸、棕榈酸甲酯、亚油酸甲酯中的一种或多种,但不限于此。
基于上述安抚植物和液体信息素,不仅能够提供具有足够安抚作用的安抚信息素,而且使得安抚信息素与香波组分相容性良好。
作为上述技术方案的改进,所述安抚植物选用猫薄荷、木天蓼、鞑靼忍冬、缬草根、假荆芥的混合物,且其重量比(猫薄荷:木天蓼:鞑靼忍冬:缬草根:假荆芥)为(0.5~2):(0.5~2):(1.5~3):(0.1~1):(0.5~1.5);
所述液体信息素选用肉豆蔻酸甲酯、油酸甲酯、正丁酸的混合物,且其重量比(肉豆蔻酸甲酯:油酸甲酯:正丁酸)为(0.5~2):(0.5~1.5):(1.5~3)。
作为上述技术方案的改进,所述安抚信息素包括以下重量份的组分:棕榈酸甲酯0.1-3份,亚油酸甲酯0.4-5份,庚二酸二甲酯0.01-1.5份,壬二酸二甲酯0.01-1.5份,癸二酸二甲酯0.01-1.5份,植物提取物0.5~5份。
作为上述技术方案的改进,所述抗真菌剂选用十一烯酸、水杨酸、灰黄霉素、克霉唑、氟康唑、酮康唑、硝酸益康唑、硝酸咪康唑、伊曲康唑、特比萘芬中的一种或多种;但不限于此。
所述抗细菌剂选用甲硝唑、克林霉素、多粘菌素、庆大霉素、新霉素、红霉素、葡萄糖酸氯己定、醋酸氯己定、苯扎溴铵、杆菌肽、莫匹罗星、马波沙星中的一种或多种,但不限于此。
作为上述技术方案的改进,所述表面活性剂包括主表面活性剂和助表面活性剂,且其重量比为(5~30):(1~35);优选的,主表面活性剂与助表面活性剂的重量比为(10-20):(10-20)。
所述主表面活性剂选用脂肪醇聚氧乙烯醚硫酸盐(AES)、十二烷基聚氧乙烯醚硫酸酯铵(ASEA)、α-烯基磺酸盐(AOS)、月桂醇硫酸酯钠(SLS)、月桂醇聚醚硫酸酯钠(SLES)、N-酰基谷氨酸钠(AGA)、十二烷基硫酸钠(K12)、十二烷基硫酸钠铵(K12A)、脂肪醇聚氧乙烯醚(AEO)、咪唑啉甜菜碱中的一种或多种;但不限于此。
所述助表面活性剂选用十二烷基二甲基甜菜碱(BS-12)、椰油酰胺丙基甜菜碱(CAB)、十二烷基二甲基氧化胺(OB-2)、椰子油二乙醇酰胺(6501)、烷基糖苷(APG)、丙二醇、甘油中的一种或多种,但不限于此。
作为上述技术方案的改进,所述增稠剂选用聚乙二醇二硬脂酸酯(638)、椰油酰胺甲基MEA(CMMEA)、甲基葡糖二油酸酯(DOE-120)的一种或多种;
所述螯合剂为枸橼酸、枸橼酸钠、乙二胺、乙二胺四乙酸(EDTA)、乙二胺四乙酸二钠(EDTA-2Na)中的一种或多种。
作为上述技术方案的改进,所述助剂包括调理剂0.1~5份和防腐剂0.01~2份;
所述调理剂选用为西曲氯铵,水溶性羊毛脂、氨基硅油、氨基硅油微乳液中的一种或多种;
所述防腐剂选用苯甲酸钠和/或卡松,但不限于此。
相应的,本发明还公开了一种上述的具有安抚作用的宠物药浴香波的制备方法,其包括:
(1)提供/制备安抚信息素;
(2)将抗真菌剂、抗细菌剂、安抚信息素、表面活性剂、增稠剂、螯合剂、助剂、水混合均匀,即得到具有安抚作用的宠物药浴香波。
作为上述技术方案的改进,所述安抚信息素的制备方法为:
(1)将安抚植物浸泡至液体信息素中12~24h,***萃取除杂后得到植物提取物;
示例性的,安抚植物在液体信息素中的浸泡时间为12h、13h、15h、17h、19h、21h或23h,但不限于此。优选的为12~15h。
(2)将植物提取物加热至40~50℃,然后依次加入棕榈酸甲酯、亚油酸甲酯、庚二酸二甲酯、壬二酸二甲酯、癸二酸二甲酯,加入完成后再搅拌10~20min,即得到安抚信息素。
实施本发明,具有以下优点:
本发明的具有安抚作用的宠物药浴香波,在配方中添加了抗真菌剂、抗细菌剂和安抚信息素,三种组分的联用既可预防和治疗猫常见的皮肤病,且可使得猫在安静状态下洗澡,减少猫的应激反应。具体的,本发明中的宠物药浴香波对于猫临床常见的皮肤病,如石膏样小孢子菌、须毛癣菌、马拉色菌、金黄色葡萄球菌、绿脓杆菌等引起的混合感染性皮肤病疗效显著。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚,下面将结合具体实施方式对本发明作进一步地详细描述。
实施例1
本实施例提供一种具有安抚作用的宠物药浴香波,其配方如下:
水杨酸1份,庆大霉素1份,安抚信息素3份,AES 10份,CAB 20份,CMMEA 1份,EDTA0.1份,氨基硅油0.3份,卡松0.1份,水63.5份。
其中,安抚信息素为猫薄荷精油,具体的,将猫薄荷采用乙醇多次提取后得到。
本实施例中宠物药浴香波的制备方法如下:
(1)将水杨酸、AES、CAB、CMMEA、氨基硅油与40份水混合,加热到60℃,使各组分溶解;
(2)边冷却边加入EDTA,并在冷却至40℃时加入庆大霉素、安抚信息素,冷却至室温后,补齐水,并加入卡松,搅拌均匀,即得。
实施例2
本实施例提供一种具有安抚作用的宠物药浴香波,其配方如下:
水杨酸1份,庆大霉素1份,安抚信息素3份,AES 10份,CAB 20份,CMMEA 1份,EDTA0.1份,氨基硅油0.3份,卡松0.1份,水63.5份。
其中,安抚信息素的配方为:
棕榈酸甲酯2份,壬二酸二甲酯3份,癸二酸二甲酯1.5份,植物提取物2份;
其中,植物提取物为猫薄荷精油,其是采用油酸甲酯浸泡提取猫薄荷24h后,经***萃取除杂而得。
本实施例中宠物药浴香波的制备方法如下:
(1)取猫薄荷,采用油酸甲酯浸泡24h,所得浸泡液采用***萃取除杂后得到植物提取物;
(2)将植物提取物加热至50℃,依次加入棕榈酸甲酯、壬二酸二甲酯和癸二酸二甲酯,搅拌混合均匀,即得安抚信息素;
(3)将水杨酸、AES、CMMEA与40份水混合,加热到60℃,使各组分溶解;
(4)边冷却边加入EDTA,并在冷却至40℃时加入庆大霉素、安抚信息素,冷却至室温后,补齐水,搅拌均匀,即得。
实施例3
本实施例提供一种具有安抚作用的宠物药浴香波,其配方如下:
硝酸咪康唑2份,葡萄糖酸氯己定3份,安抚信息素1份,AES 10份,CAB 20份,DOE-120 2份,EDTA 0.1份,氨基硅油0.3份,卡松0.1份;水61.5份。
其中,安抚信息素的配方为:
棕榈酸甲酯2.5份,亚油酸甲酯3份,庚二酸二甲酯0.5份,壬二酸二甲酯1份,癸二酸二甲酯1份,植物提取物2份;
其中,植物提取物为猫薄荷精油,其是采用油酸甲酯浸泡提取猫薄荷24h后,经***萃取除杂而得。
本实施例中宠物药浴香波的制备方法如下:
(1)取猫薄荷,采用油酸甲酯浸泡24h,所得浸泡液采用***萃取除杂后得到植物提取物;
(2)将植物提取物加热至50℃,依次加入棕榈酸甲酯、亚油酸甲酯、庚二酸二甲酯、壬二酸二甲酯和癸二酸二甲酯,搅拌混合均匀,即得安抚信息素;
(3)将硝酸咪康唑、AES、CAB、DOE-120、氨基硅油与45份水混合,加热到60℃,使各组分溶解;
(4)边冷却边加入EDTA,并在冷却至40℃时加入葡萄糖酸氯己定、安抚信息素,冷却至室温后,补齐水,并加入卡松,搅拌均匀,即得。
实施例4
本实施例提供一种具有安抚作用的宠物药浴香波,其配方如下:
硝酸咪康唑2份,葡萄糖酸氯己定3份,安抚信息素1份,AES 10份,CAB 20份,DOE-120 2份,EDTA 0.1份,氨基硅油0.3份,卡松0.1份;水61.5份。
其中,安抚信息素的配方为:
棕榈酸甲酯2.5份,亚油酸甲酯3份,庚二酸二甲酯0.5份,壬二酸二甲酯1份,癸二酸二甲酯1份,植物提取物2份;
其中,植物提取物由安抚植物经液体信息素提取而得;安抚植物为:猫薄荷1份、木天蓼3份、鞑靼忍冬0.5份、缬草根1份、假荆芥1份;液体信息素为肉豆蔻酸甲酯3份、油酸甲酯0.5份、正丁酸0.5份。
本实施例中宠物药浴香波的制备方法如下:
(1)取安抚植物,采用液体信息素浸泡24h,所得浸泡液采用***萃取除杂后得到植物提取物;
(2)将植物提取物加热至50℃,依次加入棕榈酸甲酯、亚油酸甲酯、庚二酸二甲酯、壬二酸二甲酯和癸二酸二甲酯,搅拌混合均匀,即得安抚信息素;
(3)将硝酸咪康唑、AES、CAB、DOE-120、氨基硅油与45份水混合,加热到60℃,使各组分溶解;
(4)边冷却边加入EDTA,并在冷却至40℃时加入葡萄糖酸氯己定、安抚信息素,冷却至室温后,补齐水,并加入卡松,搅拌均匀,即得。
实施例5
本实施例提供一种具有安抚作用的宠物药浴香波,其配方如下:
硝酸咪康唑2份,葡萄糖酸氯己定3份,安抚信息素1份,AES 10份,CAB 20份,DOE-120 2份,EDTA 0.1份,氨基硅油0.3份,卡松0.1份;水61.5份。
其中,安抚信息素的配方为:
棕榈酸甲酯2.5份,亚油酸甲酯3份,庚二酸二甲酯0.5份,壬二酸二甲酯1份,癸二酸二甲酯1份,植物提取物2份;
其中,植物提取物由安抚植物经液体信息素提取而得;安抚植物为:猫薄荷1份、木天蓼1.5份、鞑靼忍冬2份、缬草根0.5份、假荆芥1份;液体信息素为肉豆蔻酸甲酯1份、油酸甲酯1份、正丁酸2份。
本实施例中宠物药浴香波的制备方法如下:
(1)取安抚植物,采用液体信息素浸泡24h,所得浸泡液采用***萃取除杂后得到植物提取物;
(2)将植物提取物加热至50℃,依次加入棕榈酸甲酯、亚油酸甲酯、庚二酸二甲酯、壬二酸二甲酯和癸二酸二甲酯,搅拌混合均匀,即得安抚信息素;
(3)将硝酸咪康唑、AES、CAB、DOE-120、氨基硅油与45份水混合,加热到60℃,使各组分溶解;
(4)边冷却边加入EDTA,并在冷却至40℃时加入葡萄糖酸氯己定、安抚信息素,冷却至室温后,补齐水,并加入卡松,搅拌均匀,即得。
实施例6
本实施例提供一种具有安抚作用的宠物药浴香波,其配方如下:
硝酸咪康唑1.5份,葡萄糖酸氯己定3份,安抚信息素2份,AOS 15份,BS-12 12份,CMMEA 3份,EDTA-2Na 0.1份,氨基硅油0.2份,卡松0.01份;水63.19份。
其中,安抚信息素的配方为:
棕榈酸甲酯0.5份,亚油酸甲酯4份,庚二酸二甲酯0.5份,壬二酸二甲酯1份,癸二酸二甲酯1份,植物提取物3份;
其中,植物提取物由安抚植物经液体信息素提取而得;安抚植物为:猫薄荷1份、木天蓼1份、鞑靼忍冬2份、缬草根0.5份、假荆芥1份;液体信息素为肉豆蔻酸甲酯1份、油酸甲酯1份、正丁酸2份。
本实施例中宠物药浴香波的制备方法如下:
(1)取安抚植物,采用液体信息素浸泡24h,所得浸泡液采用***萃取除杂后得到植物提取物;
(2)将植物提取物加热至50℃,依次加入棕榈酸甲酯、亚油酸甲酯、庚二酸二甲酯、壬二酸二甲酯和癸二酸二甲酯,搅拌混合均匀,即得安抚信息素;
(3)将硝酸咪康唑、AOS、BS-12、CMMEA、氨基硅油与40份水混合,加热到60℃,使各组分溶解;
(4)边冷却边加入EDTA-2NA,并在冷却至40℃时加入葡萄糖酸氯己定、安抚信息素,冷却至室温后,补齐水,并加入卡松,搅拌均匀,即得。
效果证明试验例
(一)试验动物
选取云浮雷米高宠物厂猫皮肤病自然发病病例共计226只。
(二)试验方法
2.1试验前观察指标
2.1.1临床检查:
进行临床全身和局部检查,以及必要的皮肤刮片检查和拔毛镜检。
2.1.2微生物学检查:
对病例动物从患部采集样品,进行致病菌分离并鉴定,最后进行致病菌计数。
经检查,病例猫皮肤病真菌病原主要有:马拉色菌、犬小孢子菌、石膏样小孢子菌、须毛癣菌等;病例猫皮肤病细菌菌病原主要有:假中间葡萄球菌、铜绿假单胞菌、链球菌等。
2.2试验方法:
步骤1:洗澡前打开试验用宠物药浴香波(空白组为水)瓶敞口放置或倒入小杯中,放在洗浴间5-10分钟,将猫放进洗浴间并关门、任其自由活动15分钟,观察猫咪的行为和情绪变化,15分钟后抚摸、观察猫的反应开始药浴治疗;
步骤2:用温水缓慢浸湿猫的毛发,按1.5ml/kg体重的剂量、计算好每只猫所需宠物药浴香波。将宠物药浴香波涂在猫全身(避开眼睛、鼻子和嘴巴),洗发并按摩,确保产品与皮肤及毛皮接触10分钟。用水冲洗干净,可带上伊丽莎白圈确保猫在洗澡时不舔自己或是泡沫;每周使用两次。
2.3效果评价指标
2.3.1猫洗澡安抚效果评价指标
洗澡前和洗澡中观察猫咪是否有如下应激行为,无任何应激行为的计0分,有1-3项行为的计3分,有4-6项行为的计6分,有7-9项行为的计9分。
猫咪应激行为表现包括:全身蜷曲/一动不动,喵喵叫,呼吸急促,眼睛睁大/瞳孔放大,流口水/一直吞口水,躲在角落,耳朵贴平,颤抖,洗澡时挣扎/抓挠。
2.3.2猫临床细菌、真菌混感性皮肤病治疗效果评价指标
(1)治愈:用药后,皮肤的致病菌的分离转阴率≥80%,同时炎性分泌物显著消失,患部无异味,红疹、皮屑、脓疹等显著消失,瘙痒症状显著消失。
(2)有效:用药后,皮肤的致病菌的分离转阴率≥60%,同时炎性分泌物减少,患部基本无异味,红疹、皮屑、脓疹等减少,瘙痒症状减轻。
(3)无效:用药后,皮肤的致病菌的分离转阴率<60%,同时炎性分泌物依然存在,患部仍有异味,红疹、皮屑、脓疹等未见减少,患部仍有明显的瘙痒症状。
(4)复发率监测
对治愈后的犬猫进行停药后2周内的皮肤临床症状及皮肤微生物学检查。
(三)试验结果
3.1猫洗澡安抚评价结果
由上表可以看出,实施例1-6中加入一定量不同配比的安抚信息素均有不同程度的安抚效果,其中实施例5和6安抚效果最为明显,证明本发明中的宠物香波可有效降低猫在洗澡过程中的应激反应。
3.2临床疗效评价结果
由上表可以看出,实施例1-6的药浴香波对猫的细菌、真菌混感性皮肤病均具有一定的防治效果,其中实施例4、5和6的治愈率均达到了90%以上,证明本发明中的宠物药浴香波对猫细菌、真菌混感性皮肤病具有良好的治疗效果。
以上所述是发明的优选实施方式,应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也视为本发明的保护范围。
Claims (3)
1.一种具有安抚作用的宠物药浴香波,其特征在于,包括以下重量份的组分:抗真菌剂0.1~5份,抗细菌剂0.1~5份,安抚信息素0.1~10份,表面活性剂6~65份,增稠剂1~15份,螯合剂0.1~2份,助剂0.4~7份,水40~70份;
所述抗真菌剂为十一烯酸、水杨酸、灰黄霉素、克霉唑、氟康唑、酮康唑、硝酸益康唑、硝酸咪康唑、伊曲康唑、特比萘芬中的一种或多种;
所述抗细菌剂为甲硝唑、克林霉素、多粘菌素、庆大霉素、新霉素、红霉素、葡萄糖酸氯己定、醋酸氯己定、苯扎溴铵、杆菌肽、莫匹罗星、马波沙星中的一种或多种;
所述安抚信息素包括以下重量份的组分:棕榈酸甲酯0.1-3份,亚油酸甲酯0.4-5份,庚二酸二甲酯0.01-1.5份,壬二酸二甲酯0.01-1.5份,癸二酸二甲酯0.01-1.5份,植物提取物0.5~5份;
所述植物提取物由安抚植物的茎、叶或果实通过液体信息素提取而得;
所述安抚植物为猫薄荷、木天蓼、鞑靼忍冬、缬草根、假荆芥的混合物,且其重量比为(0.5~2):(0.5~2):(1.5~3):(0.1~1):(0.5~1.5);
所述液体信息素为肉豆蔻酸甲酯、油酸甲酯、正丁酸的混合物,且其重量比为(0.5~2):(0.5~1.5):(1.5~3);
所述安抚信息素的制备方法为:
(1)将安抚植物浸泡至液体信息素中12~24h,***萃取除杂后得到植物提取物;
(2)将植物提取物加热至40~50℃,然后依次加入棕榈酸甲酯、亚油酸甲酯、庚二酸二甲酯、壬二酸二甲酯、癸二酸二甲酯,加入完成后再搅拌10~20min,即得到安抚信息素;
所述表面活性剂包括主表面活性剂和助表面活性剂,且其重量比为(5~30):(1~35);
所述主表面活性剂为脂肪醇聚氧乙烯醚硫酸盐、α-烯基磺酸盐、N-酰基谷氨酸钠、十二烷基硫酸钠、十二烷基硫酸铵、脂肪醇聚氧乙烯醚中的一种或多种;
所述助表面活性剂为十二烷基二甲基甜菜碱、椰油酰胺丙基甜菜碱、十二烷基二甲基氧化胺、椰子油二乙醇酰胺、烷基糖苷中的一种或多种;
所述助剂包括调理剂0.1~5份和防腐剂0.01~2份;
所述调理剂为西曲氯铵,水溶性羊毛脂、氨基硅油、氨基硅油微乳液中的一种或多种。
2.如权利要求1所述的具有安抚作用的宠物药浴香波,其特征在于,所述增稠剂为聚乙二醇二硬脂酸酯、椰油酰胺甲基MEA、甲基葡糖二油酸酯中的一种或多种;
所述螯合剂为枸橼酸、枸橼酸钠、乙二胺、乙二胺四乙酸、乙二胺四乙酸二钠中的一种或多种。
3.一种如权利要求1或2所述的具有安抚作用的宠物药浴香波的制备方法,其特征在于,包括:
(1)制备安抚信息素;
(2)将抗真菌剂、抗细菌剂、安抚信息素、表面活性剂、增稠剂、螯合剂、助剂、水混合均匀,即得到具有安抚作用的宠物药浴香波。
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