CN114433866A - Method for synthesizing chiral gold nanoparticles - Google Patents
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- CN114433866A CN114433866A CN202210111255.XA CN202210111255A CN114433866A CN 114433866 A CN114433866 A CN 114433866A CN 202210111255 A CN202210111255 A CN 202210111255A CN 114433866 A CN114433866 A CN 114433866A
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 239000010931 gold Substances 0.000 title claims abstract description 56
- 229910052737 gold Inorganic materials 0.000 title claims abstract description 56
- 239000002105 nanoparticle Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims abstract description 30
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 16
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- 239000002253 acid Substances 0.000 claims abstract description 15
- 239000007795 chemical reaction product Substances 0.000 claims abstract description 14
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- 239000012069 chiral reagent Substances 0.000 claims abstract description 14
- 239000003054 catalyst Substances 0.000 claims abstract description 11
- 238000006555 catalytic reaction Methods 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000004094 surface-active agent Substances 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 9
- 235000010323 ascorbic acid Nutrition 0.000 claims description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical class C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 7
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 claims description 6
- -1 alkyl sulfuric acid Chemical compound 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 125000005210 alkyl ammonium group Chemical group 0.000 claims description 3
- 150000004996 alkyl benzenes Chemical class 0.000 claims description 3
- 229940092714 benzenesulfonic acid Drugs 0.000 claims description 3
- 239000002055 nanoplate Substances 0.000 claims description 3
- 239000002073 nanorod Substances 0.000 claims description 3
- 229920001467 poly(styrenesulfonates) Polymers 0.000 claims description 3
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- 229960002796 polystyrene sulfonate Drugs 0.000 claims description 3
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 3
- 230000035484 reaction time Effects 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 150000000996 L-ascorbic acids Chemical class 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 230000003287 optical effect Effects 0.000 abstract description 11
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- 239000002086 nanomaterial Substances 0.000 abstract description 9
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 12
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 8
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 8
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 8
- 239000008367 deionised water Substances 0.000 description 8
- 229910021641 deionized water Inorganic materials 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 229960005070 ascorbic acid Drugs 0.000 description 6
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- XUJNEKJLAYXESH-UWTATZPHSA-N D-Cysteine Chemical compound SC[C@@H](N)C(O)=O XUJNEKJLAYXESH-UWTATZPHSA-N 0.000 description 5
- 229930195710 D‐cysteine Natural products 0.000 description 5
- QAQSNXHKHKONNS-UHFFFAOYSA-N 1-ethyl-2-hydroxy-4-methyl-6-oxopyridine-3-carboxamide Chemical compound CCN1C(O)=C(C(N)=O)C(C)=CC1=O QAQSNXHKHKONNS-UHFFFAOYSA-N 0.000 description 4
- 235000013878 L-cysteine Nutrition 0.000 description 4
- 239000004201 L-cysteine Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000002983 circular dichroism Methods 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
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- 239000007864 aqueous solution Substances 0.000 description 3
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- 230000003197 catalytic effect Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000005034 decoration Methods 0.000 description 2
- RWSXRVCMGQZWBV-RITPCOANSA-N (2r)-2-amino-5-[[(2r)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid Chemical compound OC(=O)[C@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-RITPCOANSA-N 0.000 description 1
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 description 1
- RWSXRVCMGQZWBV-PHDIDXHHSA-N L-Glutathione Natural products OC(=O)[C@H](N)CCC(=O)N[C@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-PHDIDXHHSA-N 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
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- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F9/00—Making metallic powder or suspensions thereof
- B22F9/16—Making metallic powder or suspensions thereof using chemical processes
- B22F9/18—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds
- B22F9/24—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/48—Silver or gold
- B01J23/52—Gold
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
Abstract
The invention provides a method for synthesizing chiral gold nanoparticles, which comprises the following steps: mixing a dispersing agent solution, chloroauric acid, a reducing agent, a chiral reagent and gold nano seeds, and reacting to obtain a reaction product; and centrifuging and washing the reaction product to obtain the catalyst. The method synthesizes the nano-particles with single chiral crystal face and high specific activity area through the intrinsic chiral nano-particles, and has great advantages and application value in the fields of chiral surface chemistry and asymmetric catalysis; the three-dimensional swastika-shaped nanostructure has high chiral optical activity due to the unique rotating morphology, and is expected to embody the application value in the fields of assembly and optics; the method has the advantages of mild and simple reaction conditions, rapidness, simplicity and high product uniformity and stability, is favorable for large-scale preparation, and overcomes the phenomenon that single chiral nanoparticles cannot be produced on a large scale.
Description
Technical Field
The invention relates to the technical field of materials, in particular to a method for synthesizing chiral gold nanoparticles.
Background
The chiral gold nanoparticles have application value in the fields of biosensing, chiral drug safety and resolution, asymmetric catalysis, electron spinning, circularly polarizing optical devices and the like due to unique local plasmon resonance and chiral properties (chem.Soc.Rev.2021,50, 3738-. The construction of the gold nanostructure with chiral crystal faces and morphology is expected to greatly enhance the chiral optical activity and derive new optical effects (science.2009,325, 1513-1515). Meanwhile, the uniform chiral crystal face of the nanostructure provides an intrinsic asymmetric environment, and is extremely important for theoretical research and application in the field of asymmetric catalysis (Phys. chem. Phys.2020,22, 21570-21582; ACS Nano 2010,4, 5-10).
For intrinsic chiral gold nanostructures, the construction of nanostructures with uniform chiral crystal faces, the construction of more ordered three-dimensional chiral nanostructures, and the exploration and optimization of large-scale controllable preparation methods are very important for the regulation of optical and catalytic properties of chiral nanomaterials and the practical production application, and still are important problems to be solved.
Disclosure of Invention
In view of the above, the technical problem to be solved by the present invention is to provide a method for synthesizing chiral gold nanoparticles, which can synthesize gold nanoparticles with chiral crystal faces and have good asymmetric catalytic performance.
The invention provides a method for synthesizing chiral gold nanoparticles, which comprises the following steps:
mixing a dispersing agent solution, chloroauric acid, a reducing agent, a chiral reagent and gold nano seeds, and reacting to obtain a reaction product; and centrifuging and washing the reaction product to obtain the catalyst.
Preferably, the gold nano-seeds are gold nano-particles, and the particle size of the particles is 20-50 nm; the morphology of the particles includes one or more of spheres, polyhedra, octahedrons, cubes, trioctaheds, nanorods, or nanoplates.
Preferably, the dispersant solution is obtained by dispersing a dispersant in water; the dispersing agent is selected from one or more of alkyl sulfuric acid surfactants, alkyl benzene sulfonic acid surfactants, polystyrene sulfonate, polyvinylpyrrolidone, alkyl pyridine surfactants or alkyl ammonium surfactants.
Preferably, the molar concentration ratio of the gold nano-seeds to the dispersing agent solution is 1 (5-60).
Preferably, the reducing agent is one or more of ascorbic acid, citric acid and hydroxylamine hydrochloride.
Preferably, the chiral reagent is a chiral amino acid and a chiral polypeptide.
Preferably, the reaction is a constant-temperature standing reaction; the reaction temperature is 30-60 ℃; the reaction time is 2 min-12 h.
Preferably, the centrifugal rotating speed is 2000 r/m-15000 r/m.
Preferably, the molar concentration ratio of the chloroauric acid to the reducing agent to the chiral reagent to the gold nano-seeds is (1-100): (100 to 8000): (0.0002-0.4): (0.01-3).
The invention also provides application of the chiral gold nanoparticles prepared by the preparation method in any one of the technical schemes as a catalyst for asymmetric catalytic reaction.
The invention provides chiral gold nanoparticles, which are prepared by any one of the preparation methods in the technical scheme.
Compared with the prior art, the invention provides a method for synthesizing chiral gold nanoparticles, which comprises the following steps: mixing a dispersing agent solution, chloroauric acid, a reducing agent, a chiral reagent and gold nano seeds, and reacting to obtain a reaction product; and centrifuging and washing the reaction product to obtain the catalyst. The method synthesizes the nano-particles with single chiral crystal face and high specific activity area through the intrinsic chiral nano-particles, and has great advantages and application value in the fields of chiral surface chemistry and asymmetric catalysis; the three-dimensional swastika-shaped nanostructure has high chiral optical activity due to the unique rotating morphology, and is expected to embody the application value in the fields of assembly and optics; the method has the advantages of mild and simple reaction conditions, rapidness, high product uniformity and stability, and contribution to large-scale preparation, and overcomes the phenomenon that single chiral nanoparticles cannot be produced on a large scale.
Drawings
FIG. 1 is a scanned image of gold nanoparticles having uniform chiral crystal planes prepared in example 1;
fig. 2 is a scanning image of gold nanoparticles with a three-dimensional swastika-shaped morphology prepared in example 2;
FIG. 3 is a scan of gold nanoparticles with high chiral optical properties prepared in example 3;
fig. 4 is a scan of gold nanoparticles without manual optical properties of comparative example 1.
Detailed Description
The invention provides a method for synthesizing chiral gold nanoparticles, and a person skilled in the art can appropriately improve process parameters by referring to the content. It is expressly intended that all such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the scope of the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.
The invention provides a method for synthesizing chiral gold nanoparticles, which comprises the following steps:
mixing a dispersing agent solution, chloroauric acid, a reducing agent, a chiral reagent and gold nano seeds, and reacting to obtain a reaction product; and centrifuging and washing the reaction product to obtain the catalyst.
The method for synthesizing the chiral gold nanoparticles provided by the invention comprises the steps of firstly dissolving a dispersant in water to obtain a dispersant solution; preferably, a dispersing agent is added into water and is uniformly dispersed; preferably, the dispersion is made uniform by gentle shaking in a centrifuge tube.
The dispersing agent is selected from one or more of alkyl sulfuric acid surfactants, alkyl benzene sulfonic acid surfactants, polystyrene sulfonate, polyvinylpyrrolidone, alkyl pyridine surfactants or alkyl ammonium surfactants.
Then adding chloroauric acid, a reducing agent, a chiral reagent and gold nano seeds and mixing.
The invention preferably limits the adding sequence, and concretely comprises the steps of sequentially adding water, a dispersing agent, chloroauric acid, a reducing agent, a chiral reagent and gold nano-seeds.
The gold nano-seeds are gold nano-particles, and the particle size of the particles is 20-50 nm; the morphology of the particles includes one or more of spheres, polyhedra, octahedrons, cubes, trioctaheds, nanorods, or nanoplates.
According to the invention, the molar concentration ratio of the gold nano-seeds to the dispersing agent solution is preferably 1 (5-60); more preferably 1 (7-50).
The reducing agent is one or more of ascorbic acid, citric acid and hydroxylamine hydrochloride.
The chiral reagent is chiral amino acid and chiral polypeptide;
the chiral amino acids include, but are not limited to, L-cysteine, D-cysteine; the chiral polypeptide includes but is not limited to L-glutathione, D-glutathione.
According to the invention, the molar concentration ratio of the chloroauric acid, the reducing agent, the chiral reagent and the gold nano-seeds is (1-100): (100 to 8000): (0.0002-0.4): (0.01-3).
Mixing and reacting to obtain a reaction product.
The reaction is a constant-temperature standing reaction; the reaction temperature is 30-60 ℃; preferably 30-50 ℃; the reaction time is preferably 2 min-12 h; more preferably 1 to 8 hours; most preferably 1 to 6 hours.
And centrifuging and washing the reaction product to obtain the catalyst.
The present invention is not limited to the specific manner and operation of the centrifugation and washing, and those skilled in the art are familiar with the method.
The centrifugal rotating speed is preferably 2000 r/m-15000 r/m; more preferably from 5000r/m to 14000 r/m.
The invention also provides application of the chiral gold nanoparticles prepared by the preparation method in any one of the technical schemes as a catalyst for asymmetric catalytic reaction.
The chiral gold nanoparticles provided by the invention can be used as a catalyst for asymmetric catalytic reaction.
The invention provides chiral gold nanoparticles, which are prepared by any one of the preparation methods in the technical scheme.
The invention provides a method for synthesizing chiral gold nanoparticles, which comprises the following steps: mixing a dispersing agent solution, chloroauric acid, a reducing agent, a chiral reagent and gold nano seeds, and reacting to obtain a reaction product; and centrifuging and washing the reaction product to obtain the catalyst. The invention synthesizes the nano-particles with single chiral crystal face and high specific activity area by the intrinsic chiral nano-particles, and has great advantages and application value in the fields of chiral surface chemistry and asymmetric catalysis; the three-dimensional swastika-shaped nanostructure has high chiral optical activity due to the unique rotating morphology, and is expected to embody the application value in the fields of assembly and optics; the method has the advantages of mild and simple reaction conditions, rapidness, high product uniformity and stability, and contribution to large-scale preparation, and overcomes the phenomenon that single chiral nanoparticles cannot be produced on a large scale.
In order to further illustrate the present invention, the following will describe a method for synthesizing chiral gold nanoparticles in detail with reference to the following examples.
Example 1
Synthesis of gold nanoparticles with single chiral crystal face
1) Adding 1.35ml of 0.1M cetylpyridinium bromide solution and 0.45ml of 0.1M cetylpyridinium chloride aqueous solution into 2.025ml of secondary water, placing the mixture into a 7 ml centrifuge tube, and gently shaking the centrifuge tube to uniformly disperse the mixture;
2) adding 0.2ml of 10mM chloroauric acid solution to obtain an orange system;
3) adding 1.4ml of 0.1M ascorbic acid solution, and changing the system from orange to transparent;
4) adding 2.5 μ L of 0.1mM L-cysteine solution or D-cysteine solution, and shaking gently until the solution is uniform;
5) adding 12 mul gold nano-seeds wrapped by cetylpyridinium chloride, and shaking gently until the solution is uniform;
6) standing and reacting in an environment of 30 ℃ for 2 hours;
the whole reaction process is carried out in a constant-temperature water bath kettle at 30 ℃;
7) centrifugally separating the product nano particles, washing and storing in a certain amount of deionized water;
the adopted centrifugal rotating speed is 12000r/m, and deionized water is used for washing at least once;
the morphology was characterized using a scanning electron microscope and the chiral properties were characterized using a circular dichroism instrument, the results of which are shown in figure 1.
Example 2
Synthesis of gold nanoparticles with three-dimensional swastika-shaped morphology
1) Adding 1.35ml of 0.1M cetylpyridinium bromide solution and 0.45ml of 0.1M cetylpyridinium chloride aqueous solution into 2.025ml of secondary water, placing the mixture into a 7 ml centrifuge tube, and gently shaking the centrifuge tube to uniformly disperse the mixture;
2) adding 0.2ml of 10mM chloroauric acid solution to obtain an orange system;
3) adding 1.4ml of 0.1M ascorbic acid solution, and changing the system from orange to transparent;
4) adding 12.5 μ L of 0.1mM L-cysteine solution or D-cysteine solution, and shaking gently until the solution is uniform;
5) adding 48 mu l of gold nano seeds wrapped by cetylpyridinium chloride, and slightly shaking until the solution is uniform;
6) standing and reacting in an environment of 30 ℃ for 2 hours;
the whole reaction process is carried out in a constant-temperature water bath kettle at 30 ℃;
7) centrifugally separating the product nano particles, washing and storing in a certain amount of deionized water;
the adopted centrifugal rotating speed is 12000r/m, and deionized water is used for washing at least once;
the morphology was characterized using a scanning electron microscope and the chiral properties were characterized using a circular dichroism instrument, the results of which are shown in figure 2.
Example 3
Synthesis of gold nanoparticles with high chiral optical properties
1) Adding 1.35ml of 0.1M cetylpyridinium bromide solution and 0.45ml of 0.1M cetylpyridinium chloride aqueous solution into 2.025ml of secondary water, placing the mixture into a 7 ml centrifuge tube, and gently shaking the centrifuge tube to uniformly disperse the mixture;
2) adding 0.2ml of 10mM chloroauric acid solution to obtain an orange system;
3) adding 1.4ml of 0.1M ascorbic acid solution, and changing the system from orange to transparent;
4) adding 12.5 μ L of 0.1mM L-cysteine solution or D-cysteine solution, and shaking gently until the solution is uniform;
5) adding 12 mul gold nano-seeds wrapped by cetylpyridinium chloride, and shaking gently until the solution is uniform;
6) standing and reacting in an environment of 30 ℃ for 2 hours;
the whole reaction process is carried out in a constant-temperature water bath kettle at 30 ℃;
7) centrifugally separating the product nano particles, washing and storing in a certain amount of deionized water;
the adopted centrifugal rotating speed is 12000r/m, and deionized water is used for washing at least once;
the morphology was characterized using a scanning electron microscope and the chiral properties were characterized using a circular dichroism instrument, the results of which are shown in fig. 3.
Comparative example 1
Synthesis of gold nanoparticles without chiral optical properties
1) Adding 1.35ml of 0.1M cetylpyridinium bromide solution and 0.45ml of 0.1M cetylpyridinium chloride solution into 2.025ml of secondary water, placing the mixture into a 7 ml centrifuge tube, and gently shaking the centrifuge tube to uniformly disperse the mixture;
2) adding 0.2ml of 10mM chloroauric acid solution to obtain an orange system;
3) adding 1.4ml of 0.1M ascorbic acid solution, and changing the system from orange to transparent;
4) adding 6.25 μ L of 0.1mM L-cysteine solution and 6.25 μ L D-cysteine solution, and shaking gently until the solution is uniform;
5) adding 12 mul gold nano-seeds wrapped by cetylpyridinium chloride, and slightly shaking until the solution is uniform;
6) standing and reacting in an environment of 30 ℃ for 2 hours;
the whole reaction process is carried out in a constant-temperature water bath kettle at 30 ℃;
7) centrifugally separating the product nano particles, washing and storing in a certain amount of deionized water;
the centrifugal rotating speed is 12000r/m, and deionized water is used for washing at least once;
the morphology was characterized using a scanning electron microscope and the chiral properties were characterized using a circular dichroism instrument, the results of which are shown in fig. 4.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A method of synthesizing chiral gold nanoparticles, comprising:
mixing a dispersing agent solution, chloroauric acid, a reducing agent, a chiral reagent and gold nano seeds, and reacting to obtain a reaction product; and centrifuging and washing the reaction product to obtain the catalyst.
2. The method according to claim 1, wherein the gold nano-seeds are gold nano-particles, and the particle size of the particles is 20-50 nm; the morphology of the particles includes one or more of spheres, polyhedra, octahedrons, cubes, trioctaheds, nanorods, or nanoplates.
3. The method of claim 1, wherein the dispersant solution is a dispersant dispersed in water; the dispersing agent is selected from one or more of alkyl sulfuric acid surfactants, alkyl benzene sulfonic acid surfactants, polystyrene sulfonate, polyvinylpyrrolidone, alkyl pyridine surfactants or alkyl ammonium surfactants.
4. The method according to claim 1, wherein the molar concentration ratio of the gold nano-seeds to the dispersant solution is 1 (5-60).
5. The method of claim 1, wherein the reducing agent is one or more of ascorbic acids, citric acids, hydroxylamine hydrochloride; the chiral reagent is chiral amino acid and chiral polypeptide.
6. The method according to claim 1, wherein the reaction is a constant temperature standing reaction; the reaction temperature is 30-60 ℃; the reaction time is 2 min-12 h.
7. The method of claim 1, wherein the centrifugal rotation speed is 2000r/m to 15000 r/m.
8. The method according to claim 1, wherein the molar concentration ratio of the chloroauric acid, the reducing agent, the chiral reagent and the gold nano-seeds is (1-100): (100 to 8000): (0.0002-0.4): (0.01-3).
9. A chiral gold nanoparticle, which is produced by the production method according to any one of claims 1 to 8.
10. The use of chiral gold nanoparticles prepared by the preparation method of any one of claims 1 to 8 as a catalyst for asymmetric catalytic reactions.
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