CN114432178A - Skin micro-ecological balance composition and preparation method and application thereof - Google Patents
Skin micro-ecological balance composition and preparation method and application thereof Download PDFInfo
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- CN114432178A CN114432178A CN202210206256.2A CN202210206256A CN114432178A CN 114432178 A CN114432178 A CN 114432178A CN 202210206256 A CN202210206256 A CN 202210206256A CN 114432178 A CN114432178 A CN 114432178A
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- skin
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- composition
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The invention provides a skin microecological balance composition, which comprises the following components in parts by weight: 0.01-5 parts of probiotics, 0.01-10 parts of prebiotics, 0.1-2 parts of cell rejuvenation biological peptide, 0.01-1 part of tripeptide-1 copper, 0.1-10 parts of vitamin X and dipotassium glycyrrhizinate. The invention belongs to the technical field of cosmetics, and relates to a cosmetic which is characterized in that oligopeptide polypeptides are innovatively used to be matched with prebiotics and probiotics to construct micro-ecological balance, and tripeptide-1 copper, vitamin X and dipotassium glycyrrhizinate are matched to generate a synergistic interaction effect, so that the skin barrier can be strengthened, the moisture can be maintained for a long time, the irritation can be relieved, sensitive skin can be repaired, and the micro-ecological balance of the skin can be kept.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a skin micro-ecological balance composition, and a preparation method and application thereof.
Background
The skin is located on the surface of the human body, is the largest organ of the human body, and is also the most important defense system. Normally, a large number of microorganisms are present on the skin surface. Skin micro-ecology refers to a micro-ecosystem consisting of the skin microflora, the tissues on the skin surface of the host, various secretions of cells, the external environment, and the like. The skin microflora, the tissues on the skin surface of the host and the external environment are mutually restricted and interacted, and the coordinated dynamic balance is maintained, so that the skin is considered to be in a normal and healthy skin state.
Microbial populations are generally divided into two broad categories: resident flora and transient flora. The skin micro-ecological balance usually plays an important role for resident flora to maintain the healthy state of the skin, and plays a very important role in the skin of human bodies, and mainly comprises the following steps: 1) the immunity of the skin is improved; 2) the anti-allergy capability of the skin is improved; 3) the moisture retention of the skin is kept; 4) improve the renewal of skin cells. However, long-term, repeated internal and external environmental stimuli are applied to the skin and exceed the compensatory ability of the skin, which can break the microecological balance of the skin, leading to the occurrence of skin sub-health or skin diseases.
Most of skin care products on the market at present only relieve the symptom of skin micro-ecological imbalance by means of moisturizing, moisturizing and the like, and the problem of skin micro-ecological imbalance is difficult to solve fundamentally. CN110638740A discloses a composition for regulating skin micro-ecology and its application, wherein the composition comprises a yeast fermentation product lysate of bifidus, a yeast fermentation product filtrate, a lactobacillus/algae extract fermentation product, a giant kelp extract and seawater, the composition can be utilized by probiotics on the skin surface, and can selectively protect the probiotics and inhibit pathogenic bacteria at the same time, but the lava seawater used is not easily available, and the cost is also increased, and is not suitable for large-scale popularization and application. CN 111544370 a discloses a composition for regulating and maintaining skin micro-ecology, which comprises bacteriostatic agent, skin probiotic nutritional agent, lactobacillus, yeast fermentation lysate filtrate, and the composition can make the reproduction of probiotics not inhibited, but the dosage of chemical bacteriostatic agent is higher, which is not beneficial to long-term maintenance of skin micro-ecology balance.
Disclosure of Invention
In order to solve the problems in the prior art, the inventor screens and compounds the components of the skin microecological balance composition through a large number of tests, creatively uses oligopeptide polypeptides (cell revitalizing biological peptides) to match prebiotics and prebiotics to construct microecological balance, and simultaneously matches tripeptide-1 copper, dipotassium glycyrrhizinate and the like to strengthen skin barriers, keep moisture for a long time, relieve stimulation and repair sensitive skin. The present invention has been completed based on the above findings.
The objects of the invention will be further apparent and elucidated by the following detailed description.
The invention provides a skin microecological balance composition, which comprises the following components in parts by weight: 0.01-5 parts of probiotics, 0.01-10 parts of prebiotics, 0.1-2 parts of cell rejuvenation biological peptide, 0.01-1 part of tripeptide-1 copper, 0.1-10 parts of vitamin X and dipotassium glycyrrhizinate.
The combination and the range of the parts by weight of the components are determined by a large number of experiments, and the combination and the range of the parts by weight enable the skin microecological balance composition provided by the invention to generate a synergistic interaction effect, so that the skin barrier can be strengthened and strengthened, the moisture can be kept for a long time, the irritation can be relieved, the sensitive skin can be repaired, and the skin microecological balance can be kept.
Preferably, the skin microecological balance composition comprises the following components in parts by weight: 0.01-1 part of probiotics, 0.01-5 parts of prebiotics, 0.1-1 part of cell rejuvenation biological peptide, 0.05-0.2 part of tripeptide-1 copper, 0.1-5 parts of vitamin X and 0.05-0.2 part of dipotassium glycyrrhizinate.
More preferably, the skin microecological balance composition comprises the following components in parts by weight: 0.5 part of probiotics, 3 parts of prebiotics, 0.5 part of cell rejuvenation biological peptide, 0.1 part of tripeptide-1 copper, 0.1 part of vitamin X2 and 0.1 part of dipotassium glycyrrhizinate.
Preferably, the prebiotic is symrebot L19. SymReboot L19 is a fermentation product of maltodextrin and lactobacillus, provided by Germany and jasmine, which was used in the composition system of the present invention to adjust microbial flora, soothe skin erythema, maintain moisture, and strengthen skin barrier.
Preferably, the prebiotic is an ecological nutritional liquid made from water, inulin and alpha-glucan oligosaccharides. The prebiotics are carbohydrate compounds containing 60 mass percent of inulin and 15 mass percent of alpha-glucan oligosaccharide, are provided by the French Xianting trade company, and can be eaten by beneficial bacteria on the skin, promote the growth of the beneficial bacteria, are difficult to be utilized by pathogenic bacteria on the skin and inhibit the growth of harmful bacteria when the prebiotics are used in the composition system.
Preferably, the cell-rejuvenating biological peptide(s) (ii)
-BN Pro) is made from water, glycerol, butylene glycol, soluble collagen cross-linked polymer, oligopeptide-1, oligopeptide-2 and oligopeptide-5. The cell rejuvenation biological peptide is provided by Guangzhou ai rose biotech GmbH, and is a cytokine capable of promoting synthesis of collagen, elastin and hyaluronic acid.
Tripeptide-1 COPPER (WKPEP COPPER PEPTIDE) is provided by Viqi scientific Co., Ltd, Dongguan, and is a complex of COPPER ions and tripeptide, and the tripeptide complex can promote the normal production of extracellular matrix (ECM) by skin, promote the growth of skin cells and restore the skin repairing capability when the tripeptide complex is used in the composition system of the invention.
Preferably, the vitamin A is vitamin A and vitamin B
MSPeptides X) are made from glycerol, water, coco glucoside, tetrapeptide-4 and palmitoyl tripeptide-8. The Weishujing X is provided by Viqi science and technology Limited of Dongguan city, is a compound peptide acting on a TRPV1 signal channel, and can block various stimulus-mediated irritation reactions and relieve itching, stabbing pain, burning sensation and the like when the peptide is used in a composition system of the invention.
Dipotassium glycyrrhizinate is provided by Guangzhou Fuyu Longji Biotechnology Co., Ltd, is a water-soluble glycyrrhizic acid derivative which can remarkably inhibit hyaluronidase, histamine release and arachidonic acid induced inflammation and relieve skin irritation, and can effectively inhibit inflammation and allergy when being used in the composition system of the invention.
Correspondingly, the invention also provides a preparation method of the skin microecological balance composition, which comprises the following steps:
1) weighing prebiotics and prebiotics, stirring, heating to 65-72 deg.C, keeping the temperature for 5-10min, and cooling to 42-48 deg.C to obtain prebiotic mixed solution;
2) weighing cell refreshing biological peptide, tripeptide-1 copper, vitamin and calm X and dipotassium glycyrrhizinate, stirring and dissolving completely, adding into the probiotic mixed solution, homogenizing, and cooling to room temperature to obtain the skin micro-ecological balance composition.
In addition, the invention provides the application of the skin micro-ecological balance composition in preparing cosmetics, wherein the cosmetics are selected from essence, emulsion or cream.
In addition, the invention also provides a cosmetic, which comprises auxiliary materials acceptable in cosmetics and the skin microecological balance composition.
Compared with the prior art, the invention has the beneficial effects that:
(1) the invention adopts specific components and scientific and reasonable compatibility, establishes microecological balance by innovatively using oligopeptide polypeptides (cell refreshing biological peptides) in combination with prebiotics and probiotics, and simultaneously generates synergistic interaction by combining tripeptide-1 copper, vitamin X and dipotassium glycyrrhizinate, thereby strengthening and strengthening skin barrier, lasting moisture retention, relieving stimulation, repairing sensitive skin and keeping skin microecological balance.
(2) The skin microecological balance composition provided by the invention has the advantages of good safety, wide raw material source, simple preparation method and stable quality and effect of the prepared product.
Detailed Description
The present invention will be described in further detail with reference to specific examples.
In the present invention, the components and raw materials are all conventional commercially available products or can be obtained by means of conventional techniques in the art.
Example 1 skin Microecologically Balanced composition
The skin microecological balance composition comprises the following components in parts by weight: the probiotic is SymReboot L190.05 parts, the prebiotics are 0.1 part, the cell rejuvenation biological peptide is 0.1 part, the tripeptide-1 copper is 0.05 part, the vitamin X is 0.5 part, and the dipotassium glycyrrhizinate is 0.05 part.
A method of preparing a skin microecological balance composition comprising the steps of:
1) weighing prebiotics and prebiotics, stirring, heating to 70 deg.C, keeping the temperature for 8min, and cooling to 45 deg.C to obtain prebiotic mixed solution;
2) weighing cell refreshing biological peptide, tripeptide-1 copper, vitamin and calm X and dipotassium glycyrrhizinate, stirring and dissolving completely, adding into the probiotic mixed solution, homogenizing, and cooling to room temperature to obtain the skin micro-ecological balance composition.
Example 2 skin micro-ecological balance composition
The skin microecological balance composition comprises the following components in parts by weight: 190.5 parts of prebiotics SymReboot L, 3 parts of prebiotics, 0.5 part of cell rejuvenation biological peptide, 0.1 part of tripeptide-1 copper, 0.1 part of vitamin X2 and 0.1 part of dipotassium glycyrrhizinate.
The skin microecological balance composition was prepared in a similar manner to that of example 1.
Example 3 skin Microbiostatic Balancing compositions
The skin microecological balance composition comprises the following components in parts by weight: the probiotic is SymReboot L191, the prebiotics are 5, the cell rejuvenation biological peptide is 1, the tripeptide-1 copper is 0.2, the vitamin X5 and the dipotassium glycyrrhizinate are 0.2.
The skin microecological balance composition was prepared in a similar manner to that of example 1.
Examples skin microecological balance essence
Skin microecological balance essence according to examples 4 to 6 of the present invention were prepared according to the formulation of table 1, respectively, using the skin microecological balance compositions of examples 1 to 3, respectively, while providing comparative example 1 (containing no SymReboot L19 compared to example 5), comparative example 2 (containing no prebiotics compared to example 5), comparative example 3 (containing no cell rejuvenating peptides compared to example 5), comparative example 4 (containing no tripeptide-1 copper compared to example 5), comparative example 5 (containing no veshu X compared to example 5), and comparative example 6 (containing no tripeptide-1 copper, veshu X, and dipotassium glycyrrhizinate compared to example 5).
Table 1 examples and comparative examples of skin microecological balance essence of the present invention
The preparation method of the essence comprises the following steps:
sequentially adding the phase A materials into a water phase pot, stirring and heating to 78 ℃, homogenizing at a high speed for 4 minutes, and preserving heat for 15 minutes;
2. sequentially adding the C-phase material into the first container, heating and stirring to 55 ℃, and keeping the temperature for 6 minutes for later use;
3. after the heat preservation of the phase A material is finished, pumping the phase A material into an emulsifying pot, and continuously stirring to supplement the temperature to 78 ℃;
4. after the temperature compensation is finished, adding the phase B material under the low-speed homogenizing condition;
5, starting the emulsifying pot to homogenize at high speed for 8 minutes after the addition of the phase B material is finished;
6. after homogenizing in the emulsifying pot, preserving the heat for 6 minutes, and beginning to cool;
7. cooling the emulsifying pot to 60 ℃, adding the C-phase material, starting vacuum to-0.09 Kpa, and continuously cooling after 6 minutes;
8. cooling the temperature of the emulsifying pot to 45 ℃, adding the skin micro-ecological balance composition, and continuing stirring and cooling;
9. and (4) cooling the temperature of the emulsifying pot to 38 ℃, taking and inspecting the materials, detecting physical and chemical indexes, discharging and storing the materials after the materials are qualified, and otherwise, discarding the materials.
Effect example 1 sample Patch test (safety test)
30 healthy volunteers were selected and randomly divided into 3 groups, and a 5cm × 10cm area was marked on the right forearm flexor side, cleaned with physiological saline, and the marked area was spotted.
The spot pasting method comprises the following steps: cleaning the skin of the area to be tested with normal saline, and drying for 5 min; placing examples 4-6 into numbered spot tester cells, respectively, at a dose of 0.025g, asking the subject to feel, and refraining from bathing during the test period; after 24h, the plaque tester was removed and the skin reaction was observed after the indentation disappeared.
TABLE 2 grading Standard of adverse skin reactions
According to the grading standards shown in Table 2, the 30 volunteers all have a rating of 0, which indicates that the skin microecological balance essence provided by the invention has no adverse reaction on human skin and good safety.
Effect example 2 sample moisturizing effect test
Respectively adding deionized water into the essence samples prepared in the examples 4-6 and the comparative examples 1-6 according to the mass volume ratio of 1:5g/mL to dissolve uniformly to obtain sample solutions; respectively placing the sample solutions in weighing bottles with the diameter of 90mm, and weighing M0Placing the half-opened cover of the weighing bottle in a low-humidity environment with the temperature of 25 ℃ and the RH of 40 percent, and basically saturating the moisture absorption rate after 48 hours, so that the weight M of the weighing bottle is measured after standing for 48 hours1Calculating the moisture absorption rate [ (% M)1-M0)/M0]×100％；
Continuously putting the weighed sample after 48h back into a low humidity environment with the temperature of 25 ℃ and the RH of 40 percent, and accurately weighing the mass M of each weighing bottle after 48h2Calculating the moisture retention rate [ [ (M)2-M0)/(M1-M0)]×100％。
The moisturizing effect of each group of samples is shown in table 3:
TABLE 3 moisturizing effect of the groups of samples
| Group of | Moisture absorption rate% | Moisture retention rate% |
| Example 4 | 73.8 | 94.5 |
| Example 5 | 75.3 | 96.2 |
| Example 6 | 75.0 | 95.9 |
| Comparative example 1 | 70.9 | 91.8 |
| Comparative example 2 | 68.4 | 87.0 |
| Comparative example 3 | 70.5 | 91.6 |
| Comparative example 4 | 71.6 | 92.3 |
| Comparative example 5 | 69.2 | 89.1 |
| Comparative example 6 | 67.9 | 87.4 |
As can be seen from table 3, the moisture absorption rate of the skin micro-ecological balance essence provided in examples 4 to 6 of the present invention is up to 73% or more, the moisture retention rate is up to 94% or more, and the moisture retention effect is very good. In contrast, comparative examples 1 to 6 have a certain moisturizing effect, but the moisture absorption rate and the moisturizing rate were lower than those of inventive examples 4 to 6, respectively. Therefore, the components of the skin microecological balance essence, such as the prebiotics, the probiotics, the cell rejuvenation biological peptide, the tripeptide-1 copper and the like, generate synergistic effects of moisture absorption and moisture retention.
Effect example 3 sample Effect test for maintaining the Microecological balance of skin
Inoculating and culturing Staphylococcus epidermidis ATCC 12228, Bifidobacterium adolescentis ATCC 15704, Staphylococcus aureus ATCC 6538 and Propionibacterium acnes ATCC 6919 in beef extract peptone culture medium respectively, wherein the inoculation amount of each bacterium is 1.0 × 105CFU, then evenly smearing 1mL of the essence samples of examples 4-6, the essence samples of comparative examples 1-6 and deionized water (as a control group) on the inoculation surface, and after natural light culture for 24h, performing colony number detection on each bacterium, wherein the results are shown in Table 4:
TABLE 4 test results of bacterial colony number of different serum samples smeared
As can be seen from table 3, the skin micro-ecological balance essence provided in examples 4 to 6 of the present invention has an obvious promoting effect on the proliferation of skin beneficial bacteria, staphylococcus epidermidis and bifidobacterium adolescentis, and an obvious inhibiting effect on the proliferation of skin pathogenic bacteria, staphylococcus aureus and propionibacterium acnes, and is beneficial for maintaining skin micro-ecological balance. In contrast, comparative examples 1 to 6 had some proliferation promoting effects on skin beneficial bacteria, but the promoting effects were not as good as in examples 4 to 6 of the present invention; comparative examples 1 to 6 had some proliferation inhibitory effects on skin pathogenic bacteria, but the inhibitory effects were inferior to those of examples 4 to 6 of the present invention. Therefore, the components of the prebiotics, the probiotics, the cell rejuvenation biological peptide, the tripeptide-1 copper and the like in the skin microecological balance essence have the effect of synergistically maintaining the skin microecological balance.
The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention pertains, several simple deductions or substitutions can be made without departing from the spirit of the invention, and all shall be considered as belonging to the protection scope of the invention.
Claims (10)
1.A skin microecological balance composition characterized by: the composition comprises the following components in parts by weight: 0.01-5 parts of probiotics, 0.01-10 parts of prebiotics, 0.1-2 parts of cell rejuvenation biological peptide, 0.01-1 part of tripeptide-1 copper, 0.1-10 parts of vitamin X and dipotassium glycyrrhizinate.
2. The skin microecological balance composition of claim 1, wherein: the composition comprises the following components in parts by weight: 0.01-1 part of probiotics, 0.01-5 parts of prebiotics, 0.1-1 part of cell rejuvenation biological peptide, 0.05-0.2 part of tripeptide-1 copper, 0.1-5 parts of vitamin X and 0.05-0.2 part of dipotassium glycyrrhizinate.
3. The skin microecological balance composition of claim 2, wherein: the composition comprises the following components in parts by weight: 0.5 part of probiotics, 3 parts of prebiotics, 0.5 part of cell rejuvenation biological peptide, 0.1 part of tripeptide-1 copper, 2 parts of vitamin X and 0.1 part of dipotassium glycyrrhizinate.
4. The skin microecological balancing composition according to any one of claims 1 to 3, characterized in that: the prebiotic is SymReboot L19.
5. The skin microecological balance composition according to any one of claims 1 to 3, characterized in that: the prebiotics are ecological nutrient solution prepared from water, inulin and alpha-glucan oligosaccharide.
6. The skin microecological balancing composition according to any one of claims 1 to 3, characterized in that: the cell rejuvenation biological peptide is prepared from water, glycerol, butanediol, a soluble collagen cross-linked polymer, oligopeptide-1, oligopeptide-2 and oligopeptide-5.
7. The skin microecological balancing composition according to any one of claims 1 to 3, characterized in that: the visfatin X is prepared from glycerol, water, coco glucoside, tetrapeptide-4 and palmitoyl tripeptide-8.
8. Method for the preparation of a composition for the microecological balance of the skin according to any one of claims 1 to 7, characterized in that: the method comprises the following steps:
1) weighing prebiotics and prebiotics, stirring, heating to 65-72 deg.C, keeping the temperature for 5-10min, and cooling to 42-48 deg.C to obtain prebiotic mixed solution;
2) weighing cell refreshing biological peptide, tripeptide-1 copper, vitamin and calm X and dipotassium glycyrrhizinate, stirring and dissolving completely, adding into the probiotic mixed solution, homogenizing, and cooling to room temperature to obtain the skin micro-ecological balance composition.
9. Use of a skin microecological balancing composition according to any one of claims 1 to 7 in the preparation of a cosmetic product selected from a serum, an emulsion or a cream.
10. A cosmetic characterized by: a skin micro-ecological balance composition according to any one of claims 1 to 7, comprising cosmetically acceptable adjuvants.
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Application publication date: 20220506 |