CN114432178A - Skin micro-ecological balance composition and preparation method and application thereof - Google Patents
Skin micro-ecological balance composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN114432178A CN114432178A CN202210206256.2A CN202210206256A CN114432178A CN 114432178 A CN114432178 A CN 114432178A CN 202210206256 A CN202210206256 A CN 202210206256A CN 114432178 A CN114432178 A CN 114432178A
- Authority
- CN
- China
- Prior art keywords
- skin
- parts
- prebiotics
- composition
- tripeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims description 8
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 23
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims abstract description 22
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000010949 copper Substances 0.000 claims abstract description 21
- 229910052802 copper Inorganic materials 0.000 claims abstract description 21
- 239000006041 probiotic Substances 0.000 claims abstract description 20
- 235000018291 probiotics Nutrition 0.000 claims abstract description 20
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 18
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 18
- 230000003716 rejuvenation Effects 0.000 claims abstract description 15
- 239000011782 vitamin Substances 0.000 claims abstract description 15
- 229940088594 vitamin Drugs 0.000 claims abstract description 15
- 229930003231 vitamin Natural products 0.000 claims abstract description 15
- 235000013343 vitamin Nutrition 0.000 claims abstract description 15
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 15
- 239000002537 cosmetic Substances 0.000 claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 238000005303 weighing Methods 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000011259 mixed solution Substances 0.000 claims description 6
- 230000000529 probiotic effect Effects 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- -1 coco glucoside Chemical compound 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- 229920001202 Inulin Polymers 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 3
- 229940029339 inulin Drugs 0.000 claims description 3
- SCAKQYSGEIHPLV-IUCAKERBSA-N (4S)-4-[(2-aminoacetyl)amino]-5-[(2S)-2-(carboxymethylcarbamoyl)pyrrolidin-1-yl]-5-oxopentanoic acid Chemical compound NCC(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O SCAKQYSGEIHPLV-IUCAKERBSA-N 0.000 claims description 2
- 229940064062 alpha-glucan oligosaccharide Drugs 0.000 claims description 2
- 229940080421 coco glucoside Drugs 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 229920006037 cross link polymer Polymers 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 102000015532 Nicotinamide phosphoribosyltransferase Human genes 0.000 claims 1
- 108010064862 Nicotinamide phosphoribosyltransferase Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 230000008591 skin barrier function Effects 0.000 abstract description 5
- 230000037307 sensitive skin Effects 0.000 abstract description 4
- 102000015636 Oligopeptides Human genes 0.000 abstract description 3
- 108010038807 Oligopeptides Proteins 0.000 abstract description 3
- 230000007794 irritation Effects 0.000 abstract description 3
- 230000009044 synergistic interaction Effects 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 71
- 230000000052 comparative effect Effects 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 16
- 239000000686 essence Substances 0.000 description 13
- 239000000463 material Substances 0.000 description 12
- 241000894006 Bacteria Species 0.000 description 7
- 230000009286 beneficial effect Effects 0.000 description 7
- 230000014759 maintenance of location Effects 0.000 description 7
- 230000003020 moisturizing effect Effects 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 6
- 230000001804 emulsifying effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 244000052616 bacterial pathogen Species 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 241000186660 Lactobacillus Species 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 229940039696 lactobacillus Drugs 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- 241000186018 Bifidobacterium adolescentis Species 0.000 description 2
- 241000186427 Cutibacterium acnes Species 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010040914 Skin reaction Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 239000000022 bacteriostatic agent Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000006166 lysate Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 229940055019 propionibacterium acne Drugs 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 239000013535 sea water Substances 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 244000005714 skin microbiome Species 0.000 description 2
- 230000035483 skin reaction Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 1
- 229920000310 Alpha glucan Polymers 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 241001491705 Macrocystis pyrifera Species 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000751182 Staphylococcus epidermidis ATCC 12228 Species 0.000 description 1
- 102000003566 TRPV1 Human genes 0.000 description 1
- 101150016206 Trpv1 gene Proteins 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001447 compensatory effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910001431 copper ion Inorganic materials 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003158 microbiostatic effect Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a skin microecological balance composition, which comprises the following components in parts by weight: 0.01-5 parts of probiotics, 0.01-10 parts of prebiotics, 0.1-2 parts of cell rejuvenation biological peptide, 0.01-1 part of tripeptide-1 copper, 0.1-10 parts of vitamin X and dipotassium glycyrrhizinate. The invention belongs to the technical field of cosmetics, and relates to a cosmetic which is characterized in that oligopeptide polypeptides are innovatively used to be matched with prebiotics and probiotics to construct micro-ecological balance, and tripeptide-1 copper, vitamin X and dipotassium glycyrrhizinate are matched to generate a synergistic interaction effect, so that the skin barrier can be strengthened, the moisture can be maintained for a long time, the irritation can be relieved, sensitive skin can be repaired, and the micro-ecological balance of the skin can be kept.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a skin micro-ecological balance composition, and a preparation method and application thereof.
Background
The skin is located on the surface of the human body, is the largest organ of the human body, and is also the most important defense system. Normally, a large number of microorganisms are present on the skin surface. Skin micro-ecology refers to a micro-ecosystem consisting of the skin microflora, the tissues on the skin surface of the host, various secretions of cells, the external environment, and the like. The skin microflora, the tissues on the skin surface of the host and the external environment are mutually restricted and interacted, and the coordinated dynamic balance is maintained, so that the skin is considered to be in a normal and healthy skin state.
Microbial populations are generally divided into two broad categories: resident flora and transient flora. The skin micro-ecological balance usually plays an important role for resident flora to maintain the healthy state of the skin, and plays a very important role in the skin of human bodies, and mainly comprises the following steps: 1) the immunity of the skin is improved; 2) the anti-allergy capability of the skin is improved; 3) the moisture retention of the skin is kept; 4) improve the renewal of skin cells. However, long-term, repeated internal and external environmental stimuli are applied to the skin and exceed the compensatory ability of the skin, which can break the microecological balance of the skin, leading to the occurrence of skin sub-health or skin diseases.
Most of skin care products on the market at present only relieve the symptom of skin micro-ecological imbalance by means of moisturizing, moisturizing and the like, and the problem of skin micro-ecological imbalance is difficult to solve fundamentally. CN110638740A discloses a composition for regulating skin micro-ecology and its application, wherein the composition comprises a yeast fermentation product lysate of bifidus, a yeast fermentation product filtrate, a lactobacillus/algae extract fermentation product, a giant kelp extract and seawater, the composition can be utilized by probiotics on the skin surface, and can selectively protect the probiotics and inhibit pathogenic bacteria at the same time, but the lava seawater used is not easily available, and the cost is also increased, and is not suitable for large-scale popularization and application. CN 111544370 a discloses a composition for regulating and maintaining skin micro-ecology, which comprises bacteriostatic agent, skin probiotic nutritional agent, lactobacillus, yeast fermentation lysate filtrate, and the composition can make the reproduction of probiotics not inhibited, but the dosage of chemical bacteriostatic agent is higher, which is not beneficial to long-term maintenance of skin micro-ecology balance.
Disclosure of Invention
In order to solve the problems in the prior art, the inventor screens and compounds the components of the skin microecological balance composition through a large number of tests, creatively uses oligopeptide polypeptides (cell revitalizing biological peptides) to match prebiotics and prebiotics to construct microecological balance, and simultaneously matches tripeptide-1 copper, dipotassium glycyrrhizinate and the like to strengthen skin barriers, keep moisture for a long time, relieve stimulation and repair sensitive skin. The present invention has been completed based on the above findings.
The objects of the invention will be further apparent and elucidated by the following detailed description.
The invention provides a skin microecological balance composition, which comprises the following components in parts by weight: 0.01-5 parts of probiotics, 0.01-10 parts of prebiotics, 0.1-2 parts of cell rejuvenation biological peptide, 0.01-1 part of tripeptide-1 copper, 0.1-10 parts of vitamin X and dipotassium glycyrrhizinate.
The combination and the range of the parts by weight of the components are determined by a large number of experiments, and the combination and the range of the parts by weight enable the skin microecological balance composition provided by the invention to generate a synergistic interaction effect, so that the skin barrier can be strengthened and strengthened, the moisture can be kept for a long time, the irritation can be relieved, the sensitive skin can be repaired, and the skin microecological balance can be kept.
Preferably, the skin microecological balance composition comprises the following components in parts by weight: 0.01-1 part of probiotics, 0.01-5 parts of prebiotics, 0.1-1 part of cell rejuvenation biological peptide, 0.05-0.2 part of tripeptide-1 copper, 0.1-5 parts of vitamin X and 0.05-0.2 part of dipotassium glycyrrhizinate.
More preferably, the skin microecological balance composition comprises the following components in parts by weight: 0.5 part of probiotics, 3 parts of prebiotics, 0.5 part of cell rejuvenation biological peptide, 0.1 part of tripeptide-1 copper, 0.1 part of vitamin X2 and 0.1 part of dipotassium glycyrrhizinate.
Preferably, the prebiotic is symrebot L19. SymReboot L19 is a fermentation product of maltodextrin and lactobacillus, provided by Germany and jasmine, which was used in the composition system of the present invention to adjust microbial flora, soothe skin erythema, maintain moisture, and strengthen skin barrier.
Preferably, the prebiotic is an ecological nutritional liquid made from water, inulin and alpha-glucan oligosaccharides. The prebiotics are carbohydrate compounds containing 60 mass percent of inulin and 15 mass percent of alpha-glucan oligosaccharide, are provided by the French Xianting trade company, and can be eaten by beneficial bacteria on the skin, promote the growth of the beneficial bacteria, are difficult to be utilized by pathogenic bacteria on the skin and inhibit the growth of harmful bacteria when the prebiotics are used in the composition system.
Preferably, the cell-rejuvenating biological peptide(s) (ii)-BN Pro) is made from water, glycerol, butylene glycol, soluble collagen cross-linked polymer, oligopeptide-1, oligopeptide-2 and oligopeptide-5. The cell rejuvenation biological peptide is provided by Guangzhou ai rose biotech GmbH, and is a cytokine capable of promoting synthesis of collagen, elastin and hyaluronic acid.
Tripeptide-1 COPPER (WKPEP COPPER PEPTIDE) is provided by Viqi scientific Co., Ltd, Dongguan, and is a complex of COPPER ions and tripeptide, and the tripeptide complex can promote the normal production of extracellular matrix (ECM) by skin, promote the growth of skin cells and restore the skin repairing capability when the tripeptide complex is used in the composition system of the invention.
Preferably, the vitamin A is vitamin A and vitamin BMSPeptides X) are made from glycerol, water, coco glucoside, tetrapeptide-4 and palmitoyl tripeptide-8. The Weishujing X is provided by Viqi science and technology Limited of Dongguan city, is a compound peptide acting on a TRPV1 signal channel, and can block various stimulus-mediated irritation reactions and relieve itching, stabbing pain, burning sensation and the like when the peptide is used in a composition system of the invention.
Dipotassium glycyrrhizinate is provided by Guangzhou Fuyu Longji Biotechnology Co., Ltd, is a water-soluble glycyrrhizic acid derivative which can remarkably inhibit hyaluronidase, histamine release and arachidonic acid induced inflammation and relieve skin irritation, and can effectively inhibit inflammation and allergy when being used in the composition system of the invention.
Correspondingly, the invention also provides a preparation method of the skin microecological balance composition, which comprises the following steps:
1) weighing prebiotics and prebiotics, stirring, heating to 65-72 deg.C, keeping the temperature for 5-10min, and cooling to 42-48 deg.C to obtain prebiotic mixed solution;
2) weighing cell refreshing biological peptide, tripeptide-1 copper, vitamin and calm X and dipotassium glycyrrhizinate, stirring and dissolving completely, adding into the probiotic mixed solution, homogenizing, and cooling to room temperature to obtain the skin micro-ecological balance composition.
In addition, the invention provides the application of the skin micro-ecological balance composition in preparing cosmetics, wherein the cosmetics are selected from essence, emulsion or cream.
In addition, the invention also provides a cosmetic, which comprises auxiliary materials acceptable in cosmetics and the skin microecological balance composition.
Compared with the prior art, the invention has the beneficial effects that:
(1) the invention adopts specific components and scientific and reasonable compatibility, establishes microecological balance by innovatively using oligopeptide polypeptides (cell refreshing biological peptides) in combination with prebiotics and probiotics, and simultaneously generates synergistic interaction by combining tripeptide-1 copper, vitamin X and dipotassium glycyrrhizinate, thereby strengthening and strengthening skin barrier, lasting moisture retention, relieving stimulation, repairing sensitive skin and keeping skin microecological balance.
(2) The skin microecological balance composition provided by the invention has the advantages of good safety, wide raw material source, simple preparation method and stable quality and effect of the prepared product.
Detailed Description
The present invention will be described in further detail with reference to specific examples.
In the present invention, the components and raw materials are all conventional commercially available products or can be obtained by means of conventional techniques in the art.
Example 1 skin Microecologically Balanced composition
The skin microecological balance composition comprises the following components in parts by weight: the probiotic is SymReboot L190.05 parts, the prebiotics are 0.1 part, the cell rejuvenation biological peptide is 0.1 part, the tripeptide-1 copper is 0.05 part, the vitamin X is 0.5 part, and the dipotassium glycyrrhizinate is 0.05 part.
A method of preparing a skin microecological balance composition comprising the steps of:
1) weighing prebiotics and prebiotics, stirring, heating to 70 deg.C, keeping the temperature for 8min, and cooling to 45 deg.C to obtain prebiotic mixed solution;
2) weighing cell refreshing biological peptide, tripeptide-1 copper, vitamin and calm X and dipotassium glycyrrhizinate, stirring and dissolving completely, adding into the probiotic mixed solution, homogenizing, and cooling to room temperature to obtain the skin micro-ecological balance composition.
Example 2 skin micro-ecological balance composition
The skin microecological balance composition comprises the following components in parts by weight: 190.5 parts of prebiotics SymReboot L, 3 parts of prebiotics, 0.5 part of cell rejuvenation biological peptide, 0.1 part of tripeptide-1 copper, 0.1 part of vitamin X2 and 0.1 part of dipotassium glycyrrhizinate.
The skin microecological balance composition was prepared in a similar manner to that of example 1.
Example 3 skin Microbiostatic Balancing compositions
The skin microecological balance composition comprises the following components in parts by weight: the probiotic is SymReboot L191, the prebiotics are 5, the cell rejuvenation biological peptide is 1, the tripeptide-1 copper is 0.2, the vitamin X5 and the dipotassium glycyrrhizinate are 0.2.
The skin microecological balance composition was prepared in a similar manner to that of example 1.
Examples skin microecological balance essence
Skin microecological balance essence according to examples 4 to 6 of the present invention were prepared according to the formulation of table 1, respectively, using the skin microecological balance compositions of examples 1 to 3, respectively, while providing comparative example 1 (containing no SymReboot L19 compared to example 5), comparative example 2 (containing no prebiotics compared to example 5), comparative example 3 (containing no cell rejuvenating peptides compared to example 5), comparative example 4 (containing no tripeptide-1 copper compared to example 5), comparative example 5 (containing no veshu X compared to example 5), and comparative example 6 (containing no tripeptide-1 copper, veshu X, and dipotassium glycyrrhizinate compared to example 5).
Table 1 examples and comparative examples of skin microecological balance essence of the present invention
The preparation method of the essence comprises the following steps:
sequentially adding the phase A materials into a water phase pot, stirring and heating to 78 ℃, homogenizing at a high speed for 4 minutes, and preserving heat for 15 minutes;
2. sequentially adding the C-phase material into the first container, heating and stirring to 55 ℃, and keeping the temperature for 6 minutes for later use;
3. after the heat preservation of the phase A material is finished, pumping the phase A material into an emulsifying pot, and continuously stirring to supplement the temperature to 78 ℃;
4. after the temperature compensation is finished, adding the phase B material under the low-speed homogenizing condition;
5, starting the emulsifying pot to homogenize at high speed for 8 minutes after the addition of the phase B material is finished;
6. after homogenizing in the emulsifying pot, preserving the heat for 6 minutes, and beginning to cool;
7. cooling the emulsifying pot to 60 ℃, adding the C-phase material, starting vacuum to-0.09 Kpa, and continuously cooling after 6 minutes;
8. cooling the temperature of the emulsifying pot to 45 ℃, adding the skin micro-ecological balance composition, and continuing stirring and cooling;
9. and (4) cooling the temperature of the emulsifying pot to 38 ℃, taking and inspecting the materials, detecting physical and chemical indexes, discharging and storing the materials after the materials are qualified, and otherwise, discarding the materials.
Effect example 1 sample Patch test (safety test)
30 healthy volunteers were selected and randomly divided into 3 groups, and a 5cm × 10cm area was marked on the right forearm flexor side, cleaned with physiological saline, and the marked area was spotted.
The spot pasting method comprises the following steps: cleaning the skin of the area to be tested with normal saline, and drying for 5 min; placing examples 4-6 into numbered spot tester cells, respectively, at a dose of 0.025g, asking the subject to feel, and refraining from bathing during the test period; after 24h, the plaque tester was removed and the skin reaction was observed after the indentation disappeared.
TABLE 2 grading Standard of adverse skin reactions
According to the grading standards shown in Table 2, the 30 volunteers all have a rating of 0, which indicates that the skin microecological balance essence provided by the invention has no adverse reaction on human skin and good safety.
Effect example 2 sample moisturizing effect test
Respectively adding deionized water into the essence samples prepared in the examples 4-6 and the comparative examples 1-6 according to the mass volume ratio of 1:5g/mL to dissolve uniformly to obtain sample solutions; respectively placing the sample solutions in weighing bottles with the diameter of 90mm, and weighing M0Placing the half-opened cover of the weighing bottle in a low-humidity environment with the temperature of 25 ℃ and the RH of 40 percent, and basically saturating the moisture absorption rate after 48 hours, so that the weight M of the weighing bottle is measured after standing for 48 hours1Calculating the moisture absorption rate [ (% M)1-M0)/M0]×100%;
Continuously putting the weighed sample after 48h back into a low humidity environment with the temperature of 25 ℃ and the RH of 40 percent, and accurately weighing the mass M of each weighing bottle after 48h2Calculating the moisture retention rate [ [ (M)2-M0)/(M1-M0)]×100%。
The moisturizing effect of each group of samples is shown in table 3:
TABLE 3 moisturizing effect of the groups of samples
Group of | Moisture absorption rate% | Moisture retention rate% |
Example 4 | 73.8 | 94.5 |
Example 5 | 75.3 | 96.2 |
Example 6 | 75.0 | 95.9 |
Comparative example 1 | 70.9 | 91.8 |
Comparative example 2 | 68.4 | 87.0 |
Comparative example 3 | 70.5 | 91.6 |
Comparative example 4 | 71.6 | 92.3 |
Comparative example 5 | 69.2 | 89.1 |
Comparative example 6 | 67.9 | 87.4 |
As can be seen from table 3, the moisture absorption rate of the skin micro-ecological balance essence provided in examples 4 to 6 of the present invention is up to 73% or more, the moisture retention rate is up to 94% or more, and the moisture retention effect is very good. In contrast, comparative examples 1 to 6 have a certain moisturizing effect, but the moisture absorption rate and the moisturizing rate were lower than those of inventive examples 4 to 6, respectively. Therefore, the components of the skin microecological balance essence, such as the prebiotics, the probiotics, the cell rejuvenation biological peptide, the tripeptide-1 copper and the like, generate synergistic effects of moisture absorption and moisture retention.
Effect example 3 sample Effect test for maintaining the Microecological balance of skin
Inoculating and culturing Staphylococcus epidermidis ATCC 12228, Bifidobacterium adolescentis ATCC 15704, Staphylococcus aureus ATCC 6538 and Propionibacterium acnes ATCC 6919 in beef extract peptone culture medium respectively, wherein the inoculation amount of each bacterium is 1.0 × 105CFU, then evenly smearing 1mL of the essence samples of examples 4-6, the essence samples of comparative examples 1-6 and deionized water (as a control group) on the inoculation surface, and after natural light culture for 24h, performing colony number detection on each bacterium, wherein the results are shown in Table 4:
TABLE 4 test results of bacterial colony number of different serum samples smeared
As can be seen from table 3, the skin micro-ecological balance essence provided in examples 4 to 6 of the present invention has an obvious promoting effect on the proliferation of skin beneficial bacteria, staphylococcus epidermidis and bifidobacterium adolescentis, and an obvious inhibiting effect on the proliferation of skin pathogenic bacteria, staphylococcus aureus and propionibacterium acnes, and is beneficial for maintaining skin micro-ecological balance. In contrast, comparative examples 1 to 6 had some proliferation promoting effects on skin beneficial bacteria, but the promoting effects were not as good as in examples 4 to 6 of the present invention; comparative examples 1 to 6 had some proliferation inhibitory effects on skin pathogenic bacteria, but the inhibitory effects were inferior to those of examples 4 to 6 of the present invention. Therefore, the components of the prebiotics, the probiotics, the cell rejuvenation biological peptide, the tripeptide-1 copper and the like in the skin microecological balance essence have the effect of synergistically maintaining the skin microecological balance.
The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention pertains, several simple deductions or substitutions can be made without departing from the spirit of the invention, and all shall be considered as belonging to the protection scope of the invention.
Claims (10)
1.A skin microecological balance composition characterized by: the composition comprises the following components in parts by weight: 0.01-5 parts of probiotics, 0.01-10 parts of prebiotics, 0.1-2 parts of cell rejuvenation biological peptide, 0.01-1 part of tripeptide-1 copper, 0.1-10 parts of vitamin X and dipotassium glycyrrhizinate.
2. The skin microecological balance composition of claim 1, wherein: the composition comprises the following components in parts by weight: 0.01-1 part of probiotics, 0.01-5 parts of prebiotics, 0.1-1 part of cell rejuvenation biological peptide, 0.05-0.2 part of tripeptide-1 copper, 0.1-5 parts of vitamin X and 0.05-0.2 part of dipotassium glycyrrhizinate.
3. The skin microecological balance composition of claim 2, wherein: the composition comprises the following components in parts by weight: 0.5 part of probiotics, 3 parts of prebiotics, 0.5 part of cell rejuvenation biological peptide, 0.1 part of tripeptide-1 copper, 2 parts of vitamin X and 0.1 part of dipotassium glycyrrhizinate.
4. The skin microecological balancing composition according to any one of claims 1 to 3, characterized in that: the prebiotic is SymReboot L19.
5. The skin microecological balance composition according to any one of claims 1 to 3, characterized in that: the prebiotics are ecological nutrient solution prepared from water, inulin and alpha-glucan oligosaccharide.
6. The skin microecological balancing composition according to any one of claims 1 to 3, characterized in that: the cell rejuvenation biological peptide is prepared from water, glycerol, butanediol, a soluble collagen cross-linked polymer, oligopeptide-1, oligopeptide-2 and oligopeptide-5.
7. The skin microecological balancing composition according to any one of claims 1 to 3, characterized in that: the visfatin X is prepared from glycerol, water, coco glucoside, tetrapeptide-4 and palmitoyl tripeptide-8.
8. Method for the preparation of a composition for the microecological balance of the skin according to any one of claims 1 to 7, characterized in that: the method comprises the following steps:
1) weighing prebiotics and prebiotics, stirring, heating to 65-72 deg.C, keeping the temperature for 5-10min, and cooling to 42-48 deg.C to obtain prebiotic mixed solution;
2) weighing cell refreshing biological peptide, tripeptide-1 copper, vitamin and calm X and dipotassium glycyrrhizinate, stirring and dissolving completely, adding into the probiotic mixed solution, homogenizing, and cooling to room temperature to obtain the skin micro-ecological balance composition.
9. Use of a skin microecological balancing composition according to any one of claims 1 to 7 in the preparation of a cosmetic product selected from a serum, an emulsion or a cream.
10. A cosmetic characterized by: a skin micro-ecological balance composition according to any one of claims 1 to 7, comprising cosmetically acceptable adjuvants.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210206256.2A CN114432178A (en) | 2022-03-03 | 2022-03-03 | Skin micro-ecological balance composition and preparation method and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210206256.2A CN114432178A (en) | 2022-03-03 | 2022-03-03 | Skin micro-ecological balance composition and preparation method and application thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114432178A true CN114432178A (en) | 2022-05-06 |
Family
ID=81359337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210206256.2A Pending CN114432178A (en) | 2022-03-03 | 2022-03-03 | Skin micro-ecological balance composition and preparation method and application thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN114432178A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116077415A (en) * | 2023-02-28 | 2023-05-09 | 广州市望莎精细化工有限公司 | Ternary probiotic factor composition for regulating skin microecological balance |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100215726A1 (en) * | 2009-02-25 | 2010-08-26 | Peter Thomas Roth | Compositions for Diminishing the Appearance of Wrinkles |
CN107095822A (en) * | 2017-06-19 | 2017-08-29 | 广州栋方生物科技股份有限公司 | A kind of Chinese medicine composition and its production and use |
CN110179743A (en) * | 2019-06-20 | 2019-08-30 | 吴旭升 | A kind of composition and preparation method thereof adjusting skin microecological balance |
CN111265470A (en) * | 2020-03-30 | 2020-06-12 | 西安润玉医疗科技有限公司 | Microecological restoration composition and preparation method thereof |
CN111388403A (en) * | 2020-04-12 | 2020-07-10 | 广州市索柔生物科技有限公司 | Prebiotic composition and application thereof |
CN112245315A (en) * | 2020-10-14 | 2021-01-22 | 广州环亚化妆品科技有限公司 | Ceramide facial mask with moisturizing and repairing effects and preparation method thereof |
CN113143788A (en) * | 2021-05-18 | 2021-07-23 | 广州欣蔓化妆品有限公司 | Multi-effect composition and face cream with moisturizing, repairing and relieving functions |
CN113171318A (en) * | 2021-05-07 | 2021-07-27 | 广州欣蔓化妆品有限公司 | Freeze-dried powder preparation with moisturizing, whitening, relieving and repairing functions and preparation method thereof |
-
2022
- 2022-03-03 CN CN202210206256.2A patent/CN114432178A/en active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100215726A1 (en) * | 2009-02-25 | 2010-08-26 | Peter Thomas Roth | Compositions for Diminishing the Appearance of Wrinkles |
CN107095822A (en) * | 2017-06-19 | 2017-08-29 | 广州栋方生物科技股份有限公司 | A kind of Chinese medicine composition and its production and use |
CN110179743A (en) * | 2019-06-20 | 2019-08-30 | 吴旭升 | A kind of composition and preparation method thereof adjusting skin microecological balance |
CN111265470A (en) * | 2020-03-30 | 2020-06-12 | 西安润玉医疗科技有限公司 | Microecological restoration composition and preparation method thereof |
CN111388403A (en) * | 2020-04-12 | 2020-07-10 | 广州市索柔生物科技有限公司 | Prebiotic composition and application thereof |
CN112245315A (en) * | 2020-10-14 | 2021-01-22 | 广州环亚化妆品科技有限公司 | Ceramide facial mask with moisturizing and repairing effects and preparation method thereof |
CN113171318A (en) * | 2021-05-07 | 2021-07-27 | 广州欣蔓化妆品有限公司 | Freeze-dried powder preparation with moisturizing, whitening, relieving and repairing functions and preparation method thereof |
CN113143788A (en) * | 2021-05-18 | 2021-07-23 | 广州欣蔓化妆品有限公司 | Multi-effect composition and face cream with moisturizing, repairing and relieving functions |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116077415A (en) * | 2023-02-28 | 2023-05-09 | 广州市望莎精细化工有限公司 | Ternary probiotic factor composition for regulating skin microecological balance |
CN116077415B (en) * | 2023-02-28 | 2023-12-26 | 广东中科卓原生物科技有限公司 | Ternary probiotic factor composition for regulating skin microecological balance |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2886575C (en) | Composition for removing keratinous skin material comprising green tea lactobacillus | |
CN110638740A (en) | Composition capable of regulating skin micro-ecology and application thereof | |
CN115554226B (en) | Multi-strain fermentation filtrate and preparation method and application thereof | |
CN110946792A (en) | Quinoa fermented product and application thereof | |
KR20210088408A (en) | Lactobacillus Plantarum and uses thereof | |
TWI750716B (en) | Topical composition and its use for preparation of composition for improving skin disease and dermatitis | |
CN116019747B (en) | Preparation method of guava fermentation product, product and application thereof | |
CN115006295B (en) | Anti-aging composition, preparation method and application thereof in preparation of anti-aging cosmetics | |
US20240108566A1 (en) | Composition containing recombinant collagen with repairing and soothing effects, eye cream containing the composition and preparation method thereor | |
CN110464003A (en) | A kind of anti-oxidation function food of probiotics solid state fermentation and preparation method thereof | |
CN108785243A (en) | A kind of anti-aging whitening acne eliminating cream and preparation method thereof | |
CN115554220A (en) | Microbial fermentation stock solution with skin care effect and preparation method and application thereof | |
CN114432178A (en) | Skin micro-ecological balance composition and preparation method and application thereof | |
CN112940996B (en) | Probiotics for regulating and controlling epidermal microecological balance, product and application thereof | |
CN115998664B (en) | Composition containing guava fermentation product and application thereof | |
CN112402334B (en) | Application of highland barley fermentation extract | |
CN111358735A (en) | Lactobacillus rice fermentation product and preparation method thereof | |
JPH06211639A (en) | External agent for suppressing melanogenesis | |
CN116077415A (en) | Ternary probiotic factor composition for regulating skin microecological balance | |
CN115584333A (en) | Lactobacillus reuteri and application thereof | |
CN113632922A (en) | Lysate, preparation method and application | |
CN113244140A (en) | Composition for regulating skin micro-ecological balance and application and preparation method thereof | |
CN117257713B (en) | Rice ferment containing lactobacillus and preparation method and application thereof | |
CN117562836B (en) | Composite seaweed fermentation extract, preparation method, application and daily chemical product thereof | |
CN112402455B (en) | Application of fermented yak milk extract |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20220506 |