CN114431229A - Antibacterial and antiviral microcapsule and preparation method and application thereof - Google Patents
Antibacterial and antiviral microcapsule and preparation method and application thereof Download PDFInfo
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- CN114431229A CN114431229A CN202011231358.7A CN202011231358A CN114431229A CN 114431229 A CN114431229 A CN 114431229A CN 202011231358 A CN202011231358 A CN 202011231358A CN 114431229 A CN114431229 A CN 114431229A
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- antibacterial
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- 241000712461 unidentified influenza virus Species 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
- A01N59/20—Copper
Abstract
The invention discloses an antibacterial and antiviral microcapsule, and a preparation method and application thereof. The antibacterial and antiviral microcapsule is a composite microcapsule which takes the effective antibacterial and antiviral components as core materials and synthetic resins as shell materials and is modified with functional chemical groups on the surface. The preparation method comprises the following steps: preparing a core material containing antibacterial and antiviral active ingredients; preparing microcapsules by using synthetic resins as shell materials; and carrying out surface modification on the prepared microcapsule. The invention creatively combines the antibacterial and antiviral active ingredients, the synthetic resin and the functional chemical groups, and realizes the long-acting controlled release of the loaded antibacterial and antiviral active ingredients through the synergistic effect; the prepared antibacterial and antiviral microcapsule has good adhesive capacity and wide application range, has contact killing and anti-adhesion effects on various microorganisms, and can keep the surfaces of attached objects clean; meanwhile, the microcapsule has good biocompatibility and long-acting antibacterial and antiviral effects; a new strategy can be provided for public health safety protection.
Description
Technical Field
The invention belongs to the field of special chemical product manufacture, and particularly relates to an antibacterial and antiviral microcapsule, and a preparation method and application thereof.
Background
The World Health Organization (WHO) has reported that the rate of spread of infectious diseases has exceeded any time in the past in recent years.
The variation of virus with different environments becomes one of the difficult problems of difficult control. Therefore, it is particularly important to take preventive measures against the infection of pathogenic microorganisms, especially in urban areas where the population is dense. How to prevent the generation, propagation and diffusion of pathogenic microorganisms has become one of the main issues of public health and safety at present. Killing pathogenic microorganisms, reducing the propagation of the pathogenic microorganisms or blocking the diffusion of the pathogenic microorganisms are key links for controlling epidemic diseases and infectious diseases. The realization of public health safety depends on the development and progress of related scientific technology.
The prevention of epidemic diseases and large-scale outbreaks of infectious diseases mainly comprises the following ways: isolating and treating the source of disease, cutting off the transmission path of pathogenic microorganisms and protecting (susceptible) people. In the current methods, the number of (susceptible) people is usually huge, and the whole population cannot be covered, so the former two methods are frequently used. For pathogenic microorganisms in humans carried by animals, a first method is generally used, such as: avian influenza virus, mad cow disease virus, etc. (suspected infected livestock in the farm are directly killed), or some individuals infected with highly pathogenic or virulent germs, such as: typhoid bacillus, ibola virus, etc. Generally, the first method has a significant effect on limiting the large-scale spread of pathogens, but at the same time, the high equipment cost and operation cost (conditions required for achieving isolation), and the relatively delayed isolation measures (usually, specific symptoms appear, and only suspected cases are isolated) become main factors for limiting the effectiveness of the method. Therefore, cutting off the propagation pathway of pathogenic microorganisms becomes a key and effective pathway, and public places become a scene for realizing the pathway. How to reduce the possibility that the disease source contacts (susceptible) people through indirect modes (such as door handles, handrails, air, water bodies and the like) becomes a hotspot of research in the aspect. Therefore, it is necessary to develop an antibacterial and antiviral material with fast sterilization and long-term antibacterial (both immediate kill response and long-acting slow-release inhibition) effects, and an alternative solution is provided for alleviating the contradiction that the current (susceptible) population cannot be continuously and effectively protected under the condition of exposure to infection possibility.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide an antibacterial and antiviral microcapsule, and a preparation method and application thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
on one hand, the invention provides an antibacterial and antiviral microcapsule, which is a synthetic resin microcapsule loaded with antibacterial and antiviral active ingredients, and is a composite microcapsule with the antibacterial and antiviral active ingredients as core materials and the synthetic resin as shell materials, and the surface of the composite microcapsule is modified with functional chemical groups;
the functional chemical group comprises any one or the combination of at least two of metal ions, inorganic nonmetal groups and covalent modification organic chemical groups;
the metal ions comprise any one or the combination of at least two of metal ions with antibacterial and antiviral effects;
the inorganic nonmetallic group comprises any one or the combination of at least two of inorganic nonmetallic groups with antibacterial and antiviral effects;
the covalent modification organic chemical group comprises any one or combination of at least two of organic chemical groups with antibacterial and antiviral effects.
Furthermore, the particle size of the antibacterial and antiviral microcapsule is 3-300 μm, such as 3 μm, 15 μm, 30 μm, 60 μm, 100 μm, 180 μm, 240 μm, 300 μm, etc., and the particle size of the antibacterial and antiviral microcapsule is selected within the range of 3-300 μm, because the particle size exceeding the range causes the stability of the microcapsule to be reduced, the structure is easy to be damaged after being attached to the surface of an object and loses the antibacterial and antiviral effects, and the particle size smaller than the range causes the packaging amount of the antibacterial and antiviral active ingredients to be too small, and the antibacterial and antiviral efficiency to be reduced;
the thickness of the antibacterial and antiviral microcapsule wall is 0.5-50 μm, such as 0.5 μm, 1 μm, 5 μm, 10 μm, 20 μm, 30 μm, 40 μm or 50 μm, and the wall thickness of the antibacterial and antiviral microcapsule is selected to be 0.5-50 μm because the wall thickness exceeding the range can cause the microcapsule shell structure to be too compact, so that the antibacterial and antiviral effective components in the microcapsule shell are released too slowly and can not reach the concentration of inhibiting microorganisms to the lowest extent, and the antibacterial and antiviral effective components below the range can be released too fast, so that the antibacterial and antiviral time of the microcapsule is shortened.
Further, the effective antibacterial and antiviral component is any one or combination of at least two of the effective components with the effect of resisting pathogenic microorganisms (such as bacteria, viruses, fungi, spirochetes, mycoplasma, rickettsia, chlamydia, prions, parasites and the like);
preferably, the antibacterial and antiviral active ingredient comprises any one of or a combination of at least two of phenolic compounds, elementary halogen, halogen-containing compounds;
preferably, the phenolic compounds include parachlorometaxylenol, phenol, cresol, and the like;
preferably, the elemental halogen comprises iodine;
preferably, the halogen-containing compound includes iodophor, chlorine-containing compound, etc.; still preferably, the chlorine-containing compound comprises sodium hypochlorite, chloroisocyanuric acid compound; more preferably, the chloroisocyanuric acid compound comprises sodium dichloroisocyanurate.
Further, the synthetic resinous material is a synthetic resinous material in "synthetic resins and plastics industry" (middle drawing classification number TQ 32);
preferably, the synthetic resins include any one or a combination of at least two of natural polymer resins (middle drawing classification number TQ321), synthetic resins (middle drawing classification number TQ322), polycondensation resins (middle drawing classification number TQ323), polymerization resins (middle drawing classification number TQ325), and the like; preferably, the synthetic resin (middle drawing class number TQ322) includes a silicone resin, a urea resin, an unsaturated polyester resin, and the like.
Further, the metal ions include any one or a combination of at least two of copper ions, zinc ions, silver ions, and the like;
preferably, the inorganic nonmetallic groups include alkyl quaternary ammonium ions, alkyl quaternary phosphonium ions, alkyl substituted imidazolium ions (e.g., 1-butyl-3-methylimidazole), alkyl substituted pyridinium ions (e.g., 1-ethylpyridine bromide, 1-butylpyridine chloride), halide salt ions (e.g., AlCl) in ionic liquids3、BrCl3) Non-halide salt ions (e.g.: BF (BF) generator- 4、PF- 6、CF3SO- 3、SbF- 6Etc.) or a combination of at least two thereof;
preferably, the covalently modified organic chemical group includes any one or a combination of at least two of a thiocyanate group, a quaternary ammonium salt group, a quaternary phosphonium salt group, a biguanide group, an alcohol group, a phenol group, an organic metal group, a pyridine group, an imidazole group, and the like; more preferably, the source of the thiocyanate group is allyl isothiocyanate; the quaternary ammonium salt group is derived from dimethylaminoethyl methacrylate-bromododecane DMAEMA-C12Br, dimethylaminoethyl methacrylate-bromotetradecane DMAEMA-C14Br or dimethylaminoethyl methacrylate-bromohexadecane DMAEMA-C16 Br; the quaternary phosphonium salt group is derived from quaternary phosphonium-scaled polyvinyl alcohol; the source of the biguanide groups is polyhexamethylene biguanide hydrochloride PHMB; the source of the alcohol group is ethanol or isopropanol; the source of the phenolic group is lysol; the source of the organometallic group is mancozeb; the pyridine group is derived from chloroalkadine iodide; the source of the imidazole group is miconazole.
Compared with the traditional antibacterial coating, the novel antibacterial coating has the advantages that the trigger inactivation and the slow release inhibition are realized, and the anti-adhesion effect is more durable than that of the traditional coating: 1) the surface is with the antibacterial antiviral coating that the metal ion of different kinds of different concentration combinations modifies, because the microorganism has enrichment function to the metal ion, the metal ion will destroy its membrane function of cell too, make the intracellular component overflow, reach the effect of interfering with cell metabolism or interfering with intracellular enzyme activity, make it lose and use the biological function, lead to the cell death finally, achieve the effect of "triggering and deactivating" (the existing metal ion antibacterial coating needs longer time to contact with pathogenic microorganism in order to achieve better bactericidal effect, because the metal ion is in the free state, contact with bacterium in the form of random collision, and the bacterium absorbs the metal ion and must have certain contact duration too, this causes the metal ion to be unable to enrich in the bacterium very fast and make it split; the metal ions are modified on the microcapsule shell and are relatively fixed, when the thalli contacts the surface of a protected object, the thalli and the metal ions have a relatively fixed contact area and absorption probability, the effective time is shortened, and the antibacterial and antiviral coating modified by any one or the combination of at least two of the metal ions, the inorganic nonmetallic groups and the covalent modified organic chemical groups has the effect of triggering inactivation; 2) the microcapsule structure synthesized by the effective components with different concentrations and the shell materials with different concentration ratios can effectively adjust the escape rate of the effective components in the core material, thereby achieving more durable 'slow release inhibition' effect; 3) the antibacterial coating can form a layer of film after being sprayed on the surface of an object, and can form a super-hydrophobic surface in a non-contact environment, so that microorganisms are difficult to stay on the surface, and a durable anti-adhesion effect is achieved. Therefore, the components of the microcapsule are matched with each other, have synergistic effect and can quickly kill microorganisms on the surface of an object; and inhibit its regrowth for a long period of time; it also prevents possible microorganisms in the air from re-adhering to the surface; and has good biocompatibility.
On the other hand, the invention provides a preparation method of the antibacterial and antiviral microcapsule, which comprises the following steps:
(1) preparing a core material containing antibacterial and antiviral active ingredients;
(2) preparing microcapsules, wherein the microcapsules take synthetic resins as shell materials and antibacterial and antiviral active ingredients as core materials;
(3) and (3) carrying out surface modification on the microcapsule prepared in the step (2) by using functional chemical groups to obtain the antibacterial and antiviral microcapsule.
Further, the method for preparing the core material containing the antibacterial and antiviral active ingredients in the step (1) is a gradual dissolving method; preferably specifically: dissolving or dispersing the antibacterial and antiviral active ingredients in a first solvent at room temperature, filtering the obtained liquid, standing for a period of time, and mixing the obtained solution with a second solvent to obtain a core material containing the antibacterial and antiviral active ingredients; (gradually dissolving firstly, preparing the solid substance into mother liquor with higher concentration to facilitate dilution in different proportions, and secondly, filtering and purifying the dissolved substance under the condition of smaller volume to facilitate operation.)
Preferably, the filtration method is suction filtration;
preferably, the standing time is 30-60 min;
preferably, the first solvent comprises any one of water, N-methylpyrrolidone, dimethylformamide, ethanol, tetrahydrofuran, methanol, isopropanol, chloroform or dichloromethane, or a combination of at least two thereof;
preferably, the second solvent comprises any one of water, N-methylpyrrolidone, dimethylformamide, ethanol, tetrahydrofuran, methanol, isopropanol, chloroform, or dichloromethane, or a combination of at least two thereof.
Further, the method for preparing the microcapsule in the step (2) is a double emulsification method, and preferably specifically comprises the following steps: coating a core material containing an antibacterial and antiviral active ingredient in a first water layer of a water-in-oil-in-water (w/o/w) microcapsule formed by an amphiphilic block copolymer and synthetic resins (the water-in-oil-in-water has two layers of water and one layer of oil, and the first water layer refers to the core material coated by an oil phase); the microcapsule coating forming method comprises magnetic stirring, ultrasonic dispersion, mechanical shearing and the like;
preferably, the amphiphilic block copolymer comprises one or a combination of at least two of tween (e.g. tween 20, tween 80), span (e.g. span 60, span 80), Sodium Dodecyl Sulfate (SDS), Sodium Dodecyl Benzene Sulfonate (SDBS), OP-10, and the like.
Further, the method for performing surface modification on the microcapsule prepared in the step (2) by using the functional chemical group in the step (3) comprises the following steps: dripping a solution containing functional chemical groups into the product obtained in the step (2) under the stirring state, and continuously stirring for a period of time to obtain the antibacterial and antiviral microcapsule;
preferably, the modification method includes electrostatic adsorption, ionic adsorption, covalent binding, and the like.
In another aspect, the present invention provides an application of any one of the above-mentioned antibacterial and antiviral microcapsules in an antibacterial and antiviral scenario, where the antibacterial and antiviral scenario includes specific situations of different material surfaces, air flow paths, and specific water types, and the target microorganisms are inactivated by using trigger inactivation (triggered inactivation), sustained release inhibition (release inhibition), and anti-adhesion (anti-adsorption) effects of the microcapsules;
preferably, the surface made of different materials comprises glass, resin, wood, ceramic, stainless steel, leather and the like;
preferably, the air flow path comprises indoor air purification, a fresh air system and the like;
preferably, the specific water body types comprise swimming zone water bodies (class III), general industrial water zones, recreational water zones (class IV) which are not directly contacted with human bodies, general landscape requirement water zones (class V) and the like.
Compared with the prior art, the invention has the following beneficial effects: the invention creatively combines the antibacterial and antiviral active ingredients, the synthetic resins and the functional chemical groups, exerts the synergistic advantages and can realize the slow release of the antibacterial and antiviral active ingredients; the antibacterial and antiviral microcapsule has good adhesive capacity and wide application range; the product has the effects of triggering inactivation and anti-adhesion on various microorganisms, and keeps the surface of an object clean; meanwhile, the antibacterial and antiviral fabric has good biocompatibility and long-acting antibacterial and antiviral effects. The antibacterial and antiviral coating modified by metal ions with different types and different concentrations on the surface has the advantages that the microorganisms have an enrichment effect on the metal ions, and simultaneously, the metal ions can destroy the membrane function of cells of the antibacterial and antiviral coating, so that intracellular components overflow, the effect of interfering cell metabolism or interfering intracellular enzyme activity is achieved, the antibacterial and antiviral coating loses the application biological function, the cells are finally killed, the trigger inactivation effect is achieved, and the antibacterial and antiviral coating modified by any one or the combination of at least two of the metal ions, the inorganic nonmetallic groups and the covalent modified organic chemical groups has the trigger inactivation effect; the microcapsule structure synthesized by the shell materials with different concentrations of effective components and different types of different concentration proportions can effectively adjust the escape rate of the effective components in the core material, thereby achieving more durable slow-release inhibition effect; the synthetic resin microcapsule loaded with the antibacterial and antiviral active ingredients provides a new strategy for public health safety. The antibacterial coating can form a layer of film after being sprayed on the surface of an object, and can form a super-hydrophobic surface in a non-contact environment, so that microorganisms are difficult to stay on the surface, and a durable anti-adhesion effect is achieved. Therefore, the components of the microcapsule are matched with each other, have synergistic effect and can quickly kill microorganisms on the surface of an object; and inhibit its regrowth for a long period of time; it also prevents possible microorganisms in the air from re-adhering to the surface; meanwhile, the biological compatibility is good (the 'biological compatibility' is different according to different scenes, the irritation and sensitization of human skin are more targeted in the aspect of object surface disinfection, the irritation after volatility and gas inhalation is targeted in the aspect of air purification, and the biological toxicity of other aquatic organisms or the accumulated toxicity of the product in an ecological system is evaluated in the aspect of water body purification).
The antibacterial and antiviral microcapsule has good loading capacity and wide application range, and can load various antibacterial and antiviral active ingredients; the surface of the antibacterial and antiviral synthetic resin microcapsule can be modified with different functional groups according to the materials of different substrates, and can be well attached to a protected object, so that the microorganism inactivation effect is improved (the modified functional chemical groups are attached to the protected object on one hand, and are combined with the substrate by utilizing the groups, and on the other hand, the antibacterial and antiviral effect can be achieved). The synthetic resin microcapsule carrying the antibacterial and antiviral active ingredients has simple preparation process and good reproducibility, and can quickly realize large-scale preparation.
When meeting infectious agents (such as dust, liquid drops and the like), the antibacterial and antiviral microcapsule can improve the release rate of antibacterial and antiviral components (which is the characteristic of the invention that after a coating is formed, external tiny particles or liquid drops are contacted with the coating, so that the charge distribution on the surface of the coating can be influenced, the formed coating structure is changed, the structure and the thickness of a shell material are changed, and the slow release rate of active components is changed).
Drawings
FIG. 1 is a scanning electron microscope image of the antibacterial and antiviral microcapsule prepared in example 1 of example 4 of the present invention;
FIG. 2 is a scanning electron microscope photograph of the antibacterial and antiviral microcapsule prepared in example 1 dissolved in ultrapure water and left to stand for 7 days in example 4 of the present invention;
FIG. 3 is a scanning electron microscope image of the antibacterial and antiviral microcapsule prepared in example 1 according to the present invention after being dissolved in ultrapure water, left for 7 days and then sprayed on the surface of an object, and dried in example 4;
FIG. 4 is a graph showing the content of active ingredients in antibacterial and antiviral microcapsules prepared in example 1 of the present invention as a function of time, in which the solid line shows the actual change in the content of active ingredients in the microcapsules and the dotted line shows a regression line indicating the trend of the change in the content of active ingredients in the microcapsules;
FIG. 5 is a graph showing the results of the "antibacterial ring" test of the antibacterial and antiviral microcapsules prepared in example 1 of the present invention in example 6, wherein the left blank control is a filter paper disc impregnated with 100. mu.L of physiological saline (antibacterial ring against Escherichia coli), the right blank control is a filter paper disc impregnated with 100. mu.L of physiological saline (antibacterial ring against Escherichia coli) after the microcapsules are diluted 1000 times, and the dilution is 1000 times, and the results are shown in the table of the measurement of the size of the antibacterial ring against different strains;
FIG. 6 is a graph showing the antimicrobial effect of the antibacterial and antiviral microcapsules prepared in example 1 of the present invention on the surface of an object, FIG. 6a is the result of culturing Escherichia coli on the surface of a control object that was not treated during the test, FIG. 6b is the result of culturing Escherichia coli on the surface of an object that was sprayed with the coating of example 1 for 30min during the test, FIG. 6c is the result of culturing Escherichia coli on the surface of a control object that was not treated for 7 days, and FIG. 6d is the result of culturing Escherichia coli on the surface of an object that was sprayed with the coating of example 1 for 7 days;
FIG. 7 is a graph showing the effect of the presence or absence of the antibacterial and antiviral microcapsules prepared in spray coating example 1 on the microbial kill rate in the air filter in example 8 of the present invention;
FIG. 8 is a graph showing the results of measurements of the microbial kill rates of the microcapsules prepared according to different concentrations of metal ions in example 9 of the present invention;
FIG. 9 is a graph showing the results of detecting the microbial killing efficiency of the microcapsules containing different ratios of Cu ions to Zn ions in example 10;
FIG. 10 is a graph showing the results of hydrophobicity tests performed on the surface of an object by the antibacterial and antiviral microcapsules prepared in example 1 of the present invention in example 11, wherein FIG. 10-1 is the contact angle of a general glass surface, FIG. 10-2 is the contact angle of a surface of a certain brand claiming that a "coating layer having an antibacterial and hydrophobic function" is coated on the glass, FIG. 10-3 is the contact angle of a surface of a microcapsule prepared in example 1 of the present invention after the microcapsule is coated on the glass, and FIG. 10-4 is the contact angle of a surface of a microcapsule prepared in example 1 of the present invention after the microcapsule is coated on the glass and is left for one month in an ambient temperature environment;
FIG. 11 is a graph showing the results of testing the adhesion of the antibacterial and antiviral microcapsules prepared in example 1 of example 12 of the present invention in an air filter.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
EXAMPLE 1 preparation of antibacterial and antiviral microcapsules
The present example provides an antibacterial and antiviral microcapsule. The antibacterial and antiviral microcapsule is a synthetic resin microcapsule which carries antibacterial and antiviral active ingredients and is modified with functional chemical groups on the surface. The preparation method comprises the following steps:
(1) 3.80g of sodium dichloroisonitrile urate is dissolved in 100mL of ultrapure water at room temperature, the resulting liquid is suction-filtered, and left to stand in a dark and cool place for 30 min. Adding the liquid into 900mL of ultrapure water, and uniformly stirring and mixing to obtain a sodium dichloroisonitrile solution with the concentration of 3800 ppm;
(2) dissolving Tween 80 with the mass fraction of 2% (Tween 80 and Tween 80 with the mass fraction of 2% in a system consisting of 500mL of ethyl acetate), adding 200mL of the solution obtained in the step (1), and stirring to obtain an emulsified system. Preparing 1% by mass of an ultrapure water solution of ethyl orthosilicate (the mass fraction of the ethyl orthosilicate in a system of 2L of the ultrapure water solution of ethyl orthosilicate is 1%), adding a proper amount of ethanol, and adjusting the pH value to be acidic to obtain a prepolymerization system. Adding the emulsifying system into a prepolymerization system under a stirring state, and continuously stirring for 12h to obtain a microcapsule product;
(3) dripping 1mL of copper sulfate solution with the concentration of 0.1mol/L under the stirring state, continuously stirring for 12h, washing the solution for multiple times by using ethanol and DDI (Distilled De-Ionized water) after the reaction is finished, and drying the solution in a constant-temperature oven at the temperature of 60 ℃ to obtain the antibacterial and antiviral microcapsule with the particle size of 10-100 mu m and the wall thickness of 1-3 mu m; wherein the available chlorine content is 30.1%.
EXAMPLE 2 preparation of antibacterial and antiviral microcapsules
The present embodiment provides an antibacterial and antiviral microcapsule. The antibacterial and antiviral microcapsule is a synthetic resin microcapsule which carries antibacterial and antiviral active ingredients and is modified with functional chemical groups on the surface. The preparation method comprises the following steps:
(1) dissolving 7.45g of sodium hypochlorite in 100mL of ultrapure water at room temperature, carrying out suction filtration on the obtained liquid, and standing for 30min in a shady and cool place in a dark place. Adding the liquid into 900mL of ultrapure water, and stirring and mixing uniformly to obtain a sodium hypochlorite solution with the concentration of 0.1 mol/L;
(2) and (3) dissolving the span 80 with the mass fraction of 2.5% in 300mL of dichloromethane, adding 100mL of the solution obtained in the step (1), and stirring to obtain an emulsified system. Mixing melamine and formaldehyde according to the mass ratio of 1: 3, heating to 70-80 ℃, adjusting the pH value to 8.1-9.6 by using a sodium carbonate solution, and stirring at 800rpm for 5min to obtain a melamine formaldehyde prepolymerization system. Taking 100mL of a prepolymerization system, adding the emulsification system into the prepolymerization system under a stirring state, and keeping the temperature and continuously stirring for 1h to obtain a microcapsule product;
(3) dripping 1mL of zinc nitrate solution with the concentration of 0.3mol/L under the stirring state, continuously stirring for 12h, washing with ethanol and DDI water for multiple times after the reaction is finished, and drying in a constant-temperature oven at 60 ℃ to obtain the antibacterial and antiviral microcapsule with the particle size of 20-150 mu m and the wall thickness of 1.2-3.6 mu m; wherein the available chlorine content is 28.6%.
EXAMPLE 3 preparation of antibacterial and antiviral microcapsules
The present example provides an antibacterial and antiviral microcapsule. The antibacterial and antiviral microcapsule is a synthetic resin microcapsule which carries antibacterial and antiviral active ingredients and is modified with functional chemical groups on the surface. The preparation method comprises the following steps:
(1) dissolving 0.1mol of molecular iodine in 100mL of ethyl acetate at room temperature, carrying out suction filtration on the obtained liquid, and standing for 30min in a shady and cool place in a dark place. Adding the liquid into 900mL ethyl acetate, and stirring and mixing uniformly to obtain a molecular iodine solution;
(2) dissolving 1.5 mass percent of sodium dodecyl benzene sulfonate SDBS in 100mL of isobutanol, adding the solution obtained in the step (1), stirring, and adding the mixture in N2Refluxing and condensing under the protection of gas, stirring at 1000rpm in a water bath at 72 ℃ for 20min to uniformly disperse the emulsion, and then performing ultrasonic treatment for 10min to obtain an emulsification system. Then 5mL of pyrrole monomer is dripped, after the color is changed into dark brown, the stirring speed is adjusted to 500rpm slowly, and the reaction is carried out for 2 hours, thus obtaining a microcapsule product;
(3) dripping 1mL of silver chloride solution with the concentration of 0.2mol/L under the stirring state, continuously stirring for 12h, washing with ethanol and DDI water for multiple times after the reaction is finished, and drying in a constant-temperature oven at 60 ℃ to obtain the antibacterial and antiviral microcapsule with the particle size of 12-100 mu m and the wall thickness of 2.0-3.2 mu m.
Example 4 scanning electron microscopy characterization of the antibacterial and antiviral microcapsules prepared in example 1
Scanning electron microscope observation is carried out on the antibacterial and antiviral microcapsule prepared in the example 1, as shown in figure 1, the microcapsule can be observed to be spherical, the surface is smooth, and the particle size is uniform; dissolving the prepared antibacterial and antiviral microcapsule in 1% (w/v) ultrapure water, standing for 7 days, and observing the shape of the microcapsule, wherein the microcapsule still keeps a spherical shape and is intact as shown in figure 2; and then spraying the antibacterial and antiviral microcapsules standing for 7 days on the surface of an object, and observing the form of the antibacterial and antiviral microcapsules after drying, wherein the result is shown in figure 3, so that the microcapsules are attached to the surface of the object to form a compact protective layer, and the form of the microcapsules is still intact. The above results show that the microcapsule is successfully prepared, can be kept stable in a solvent, and is still effective after a certain time, so that the effect is achieved.
EXAMPLE 5 examination of the ability of the microcapsules prepared in example 1 to coat, release effective antibacterial and antiviral ingredients
This example evaluates the basic properties of the antibacterial and antiviral microcapsules prepared in example 1 of the present invention, i.e., the ability of the antibacterial and antiviral microcapsules prepared in example 1 of the present invention to coat and release effective antibacterial and antiviral components was investigated in an aqueous solution. The specific operation is as follows:
taking 10mg of the antibacterial and antiviral microcapsule prepared in the example 1, putting the microcapsule into an iodometry bottle, adding excessive potassium iodide and 50mL of water, adding 5mL of acetate buffer solution, sealing, shaking uniformly, standing in the dark for 10min, titrating with a sodium thiosulfate solution to be calibrated until the solution is light yellow, adding 1mL of starch solution as an indicator, continuing to titrate until blue just disappears, recording the dosage of a standard solution, and converting into the effective chlorine content. In this way, the content of the effective ingredient in the microcapsule was measured with time, and the results are shown in fig. 4. Wherein, the solid line is the actual change of the content of the effective components in the microcapsule, and the dotted line is a regression line, indicating the change trend of the content of the effective components in the microcapsule. The result shows that the content of the effective components in the microcapsule is reduced by less than 50 percent in 30 days, thereby providing support for the long-acting property of the microcapsule.
Example 6 examination of antibacterial and antiviral Capacity of the microcapsules prepared in example 1
This example evaluates the antibacterial and antiviral properties of the antibacterial and antiviral microcapsules prepared in example 1 of the present invention by contacting the microcapsules with various kinds of microorganisms and measuring their antibacterial and antiviral abilities. The specific operation is as follows:
inoculation concentration in tryptone soy agar plates was 107CFU/ml of bacteria was dropped into 100. mu.L of the medium and then spread to distribute the microorganisms evenly on the agar. A filter paper disk soaked with 100. mu.L of the antibacterial and antiviral microcapsules prepared in example 1 diluted by a certain fold or a filter paper disk soaked with 100. mu.L of physiological saline was placed on the surface of the agar. The inoculated tryptone soy agar plates were then transferred to an incubator at 37 ℃ for 24 h. The zone of inhibition where the microorganism does not grow is measured. The size of the zone of inhibition represents the antibacterial effect. The results are shown in FIG. 5. In FIG. 5, the left "blank control" is a control of a filter paper disk (zone of inhibition of Escherichia coli) impregnated with 100. mu.L of physiological saline, and the right "diluted 1000 times" is a control of a filter paper disk (zone of inhibition of Escherichia coli) impregnated with 100. mu.L of a diluted 1000-fold microcapsule. The size of the zone formed by the inhibition of the different species was determined and the results are shown in the table of FIG. 5. This example demonstrates that at lower dosages, the microcapsules still have significant bacteriostatic effects.
Example 7 detection of antimicrobial Properties of microcapsules prepared in example 1 on the surface of an object
This example was a field test of the antibacterial and antiviral microcapsules prepared in example 1. The specific operation is as follows:
standard environmental sampling techniques and transport systems: a sterile swab is used to collect a sample from a target surface. The swab may be dried or kept moist with a medium prior to application. The swab tip is used to wipe back and forth across a prescribed surface while rotating the swab tip to collect a sufficient amount of material at its tip. The swab tip is cut or bent into a buffered medium for transport. The wiping step may be applied to a flat or curved surface. The resulting solution was available for further analysis.
A microbial collection and transfer system is a device that transports samples collected on site to a laboratory. It provides a storage and buffering action that allows the microorganisms to maintain a good state.
In this experiment, a sterile swab was pre-wetted with neutralizer solution (0.001M sodium thiosulfate solution, 0.9% sodium chloride (M/v), 0.2% Tween 80(M/v), solvent sterile DDI water). The swab tip was gently wiped back and forth over the stainless steel surface for 10s with the cotton swab rotating. Cutting the swab tip and immersing in 1mL of storage solution neutralizer;
sample treatment and microbial identification: samples taken from the field were immediately sent to the laboratory and processed within 2 h. Vortex for 20 seconds to allow bacteria to escape from the swab. The 1mL of the stock solution was added to 9mL of liquid medium and cultured with shaking for 5 hours. The agarose gel plates were inoculated with 100. mu.L of the culture broth, and the plate was inverted and incubated overnight at 37 ℃ to obtain the results shown in FIG. 6. FIG. 6a shows the surface of an untreated control object after incubation, FIG. 6b shows the surface of the object after incubation of E.coli after spraying the coating of example 1 for 30min, FIG. 6c shows the surface of the untreated control object after incubation of E.coli for 7 days, and FIG. 6d shows the surface of the object after incubation of E.coli after spraying the coating of example 1 for 7 days. From the results, it was found that the surface of the non-disinfectant body was always highly contaminated with microorganisms, and the coated body maintained excellent antimicrobial effect both for a short period of time (30 min after use) and for a long period of time (seven days or more). The "trigger off" and "sustained release inhibition" properties of the antimicrobial microcapsule coating are demonstrated.
Example 8 detection of the ability of the microcapsules prepared in example 1 to kill microorganisms in an air filter
This example performed a field test on the antibacterial and antiviral microcapsules prepared in example 1. The specific operation is as follows:
half of the high efficiency filter is covered by a plastic plate and the antimicrobial coating is sprayed evenly on the uncovered side. The coated side is the treated sample and the uncoated portion is the blank. After that, the filter was left to dry overnight in a fume hood. The air purifier with the label is positioned at a place where the flow of people in the corridor is large in the building. Each set is set to at least 3Air purifiers to meet the minimum number of valid samples. The air purifiers are set to operate at medium wind speed according to the air flow rate of each air purifier. The entire air purifier was sterilized with 75% ethanol prior to placing the half-coated filter into the air purifier. After a period of time (1 week/2 weeks/4 weeks), the sample filter was aseptically removed from the purifier and placed in a sterile plastic bag. A new semi-coated filter will be placed in the purifier for another test. The sterile plastic bags were then sealed and transferred to the laboratory for further processing within 2 h. In the laboratory, the sample filters are aseptically cut in a biosafety cabinet using a pair of sterile forceps, scissors, and cutters. 2cm by 2cm samples were taken from the top, middle and bottom of the filter. The unfolded filter will be cut into small pieces. The filter plate was then transferred to a 100mL sterile vial containing 10mL of neutralizing agent. The bottle with the filter plate was gently shaken for 1min to extract the microorganisms in the filter. 100. mu.L of each solution was dropped on tryptone soy agar and malt extract agar. Tryptone soy agar was incubated in an oven at 37 ℃ for 48h and malt extract agar was incubated at room temperature for approximately one week. Converting Colony Forming Units (CFU) and converting into CFU/cm3The results are shown in FIG. 7. The black column is the non-spraying side of the filter, and compared with the spraying side of the gray column, the result shows that the spraying side can effectively improve the sterilization efficiency of the filter within one week after the test; the sterilization efficiency begins to decrease with the time on the side without spraying, and the sterilization efficiency can be maintained at nearly 100% for 4 weeks on the side with spraying.
EXAMPLE 9 detection of microbial kill by microcapsules prepared with different concentrations of Metal ions
Microcapsules were prepared in the same procedure as in example 1 except that "1 mL of a copper sulfate solution having a concentration of 0.01mol/L was dropped under stirring" in step (3) was changed to "1 mL of a copper sulfate solution having a concentration of 50mmol/L, 30mmol/L, 10mmol/L, 5mmol/L or 1mmol/L under stirring", and the antimicrobial properties thereof were measured according to section 2.1 of Disinfection Specification (2002 edition) to judge the difference in the antimicrobial properties of the microcapsules prepared with the metal ions of different concentrations, and the results are shown in FIG. 8. As can be seen from FIG. 8, the microcapsules prepared when the copper ion concentration is 50mmol/L, 30mmol/L, 10mmol/L, 5mmol/L and 1mmol/L all have good antibacterial and antiviral properties, and the killing rate on microorganisms is above 99%.
EXAMPLE 10 detection of microbial kill rates of microcapsules prepared with different kinds of Metal ion ratios
Microcapsules were prepared in the same procedure as in example 1, except that "1 mL of a copper sulfate solution having a concentration of 0.01mol/L was dropped under stirring" in step (3) was changed to "1 mL of a mixed solution of copper and zinc ions having a total concentration of 0.01mol/L (molar ratio of Cu to Zn, respectively) was dropped under stirring2+：Zn2+1: 0,3: 1,1: 1,1: 3 or 0: 1) ", the antimicrobial properties were measured according to section 2.1 of the Disinfection Specification (2002 edition), and the difference in the antimicrobial properties of the microcapsules prepared by mixing different kinds of metal ions was judged, and the results are shown in FIG. 9. As can be seen from FIG. 9, molar ratio of Cu2+：Zn2+1: 0,3: 1,1: 1,1: 3 or 0: the microcapsules prepared in the step 1 have good antibacterial and antiviral performances, and the killing rate on microorganisms is over 99.9%.
Example 11 hydrophobicity test of the microcapsules prepared in example 1 after coating on the surface of an object
The contact angle of the surface of ordinary glass is measured respectively, and the contact angle of the surface which is naturally aired after a certain brand claims that the coating with the antibacterial hydrophobic function is coated on the surface of the glass, the contact angle of the surface which is naturally aired after the microcapsule prepared in the embodiment 1 of the invention is coated on the surface of the glass, and then the contact angle of the surface after the microcapsule is placed for one month in a normal temperature environment is shown in fig. 10. Fig. 10-1 shows a contact angle of a general glass surface (average contact angle is 7.05 °), fig. 10-2 shows a contact angle of a surface of a glass coated with a coating layer alleged by a certain brand to have an antibacterial hydrophobic function (average contact angle is 71.23 °), fig. 10-3 shows a contact angle of a surface of a glass coated with a microcapsule prepared in example 1 of the present invention (average contact angle is 122.58 °), and fig. 10-4 shows a contact angle of a surface of a glass coated with a microcapsule prepared in example 1 of the present invention (about 122 °) after the microcapsule is left for one month in an ambient temperature environment. As can be seen from fig. 10, the contact angle of the ordinary glass is small, and the glass has no hydrophobicity; certain brands claim that the application of a "hydrophobic functional antimicrobial" coating increases the contact angle of the glass surface to some extent, increasing the hydrophobicity of the glass surface. The microcapsule prepared in the embodiment 1 of the present invention can be coated to significantly increase the contact angle of the glass surface (from-7 ° to-122 °), and maintain the effect for a long time, and has high stability while significantly increasing the hydrophobicity of the glass surface.
Example 12 testing of adhesion of microcapsules prepared in example 1 to an air filter
The microcapsules prepared in example 1 were sprayed on a cross-sectional area of 638cm2Effective area of 2476cm2And dried in a high efficiency air filter (HEPA). Blowing with blower (2550r/min,80W, 50Hz, 220V, 300Pa) for 24h at air flow rate of 540m3And/h, measuring the weight of the filter as a function of time, and calculating the mass change percentage to judge the adhesion of the microcapsule under the high wind speed environment, and the result is shown in fig. 11. Δ m% is the average percent mass change, with lower Δ m% demonstrating less mass change and more stable microcapsule adhesion. From the results 11, it was found that Δ m% slightly increased to 0.086% at the start of blowing, and fell back to 0.05% or less after a while, and no change in average mass of more than 0.001% was measured from 2 hours later. Therefore, the microcapsules in the embodiment are sprayed on the high-efficiency air filter, and have good adhesion force under high wind speed flow.
The applicant states that the materials, preparation methods and applications of the antibacterial and antiviral microcapsules of the present invention are illustrated by the above examples, but the present invention is not limited to the above examples, i.e., the present invention is not limited to the above examples. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.
It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.
Claims (10)
1. An antibacterial and antiviral microcapsule is characterized in that the antibacterial and antiviral microcapsule is a synthetic resin microcapsule carrying antibacterial and antiviral active ingredients, and is a composite microcapsule which takes the antibacterial and antiviral active ingredients as core materials and synthetic resins as shell materials and is modified with functional chemical groups on the surface;
the functional chemical group comprises any one of metal ions, inorganic nonmetal groups and covalent modified organic chemical groups or a combination of at least two of the metal ions, the inorganic nonmetal groups and the covalent modified organic chemical groups;
the metal ions comprise any one or the combination of at least two of metal ions with antibacterial and antiviral effects;
the inorganic nonmetallic group comprises any one or the combination of at least two of inorganic nonmetallic groups with antibacterial and antiviral effects;
the covalent modification organic chemical group comprises any one or combination of at least two of organic chemical groups with antibacterial and antiviral effects.
2. The antibacterial and antiviral microcapsule according to claim 1, wherein the antibacterial and antiviral microcapsule has a particle size of 3 to 300 μm;
the thickness of the antibacterial and antiviral microcapsule wall is 0.5-50 μm.
3. The antibacterial and antiviral microcapsule according to claim 1 or 2, wherein said antibacterial and antiviral active ingredient is any one or a combination of at least two of active ingredients having an effect against pathogenic microorganisms including bacteria, viruses, fungi, spirochetes, mycoplasma, rickettsia, chlamydia, prions, parasites;
preferably, the effective antibacterial and antiviral component comprises any one of or a combination of at least two of phenolic compounds, elementary halogen and halogen-containing compounds;
preferably, the phenolic compounds include parachlorometaxylenol, phenol, cresol;
preferably, the elemental halogen comprises iodine;
preferably, the halogen-containing compound comprises iodophors, chlorine-containing compounds; still preferably, the chlorine-containing compound comprises sodium hypochlorite, chloroisocyanuric acid compound; more preferably, the chloroisocyanuric acid compound comprises sodium dichloroisocyanurate.
4. The antibacterial and antiviral microcapsule according to claim 1 or 2, wherein said synthetic resins are synthetic resins in "synthetic resins and plastics industry";
preferably, the synthetic resins include any one or a combination of at least two of natural polymer resins, synthetic resins, polycondensation resins and polymerization resins; preferably, the synthetic resin includes silicone resin, urea resin, unsaturated polyester resin.
5. The antibacterial and antiviral microcapsule according to claim 1 or 2, wherein said metal ions comprise any one or a combination of at least two of copper ions, zinc ions, silver ions;
preferably, the inorganic nonmetallic group includes any one of alkyl quaternary ammonium ion, alkyl quaternary phosphonium ion, alkyl substituted imidazolium ion, alkyl substituted pyridinium ion, halide salt ion, non-halide salt ion or a combination of at least two of them in the ionic liquid; preferably, the covalently modified organic chemical group includes any one or a combination of at least two of a thiocyanate group, a quaternary ammonium salt group, a quaternary phosphonium salt group, a biguanide group, an alcohol group, a phenol group, an organic metal group, a pyridine group, an imidazole group, and the like.
6. A process for the preparation of antibacterial and antiviral microcapsules according to any of claims 1 to 5, characterized in that it comprises the following steps:
(1) preparing a core material containing antibacterial and antiviral active ingredients;
(2) preparing microcapsules, wherein the microcapsules take synthetic resins as shell materials and antibacterial and antiviral active ingredients as core materials;
(3) and (3) carrying out surface modification on the microcapsule prepared in the step (2) by using a functional chemical group to obtain the antibacterial and antiviral microcapsule.
7. The method of preparing a core material containing an antibacterial and antiviral active ingredient according to claim 6, wherein the method of preparing the core material containing an antibacterial and antiviral active ingredient according to step (1) is a stepwise dissolution method, preferably specifically: dissolving or dispersing the antibacterial and antiviral active ingredients in a first solvent at room temperature, filtering the obtained liquid, standing for a period of time, and mixing the obtained solution with a second solvent to obtain a core material containing the antibacterial and antiviral active ingredients;
preferably, the filtration method is suction filtration;
preferably, the standing time is 30-60 min;
preferably, the first solvent comprises any one of water, N-methylpyrrolidone, dimethylformamide, ethanol, tetrahydrofuran, methanol, isopropanol, chloroform or dichloromethane, or a combination of at least two thereof;
preferably, the second solvent comprises any one of water, N-methylpyrrolidone, dimethylformamide, ethanol, tetrahydrofuran, methanol, isopropanol, chloroform, or dichloromethane, or a combination of at least two thereof.
8. The process according to claim 6, wherein the process for preparing microcapsules of step (2) is a double emulsification process, preferably specifically: coating a core material containing an antibacterial and antiviral active ingredient in a first water layer of a water-in-oil-in-water microcapsule formed by an amphiphilic block copolymer and synthetic resins; the microcapsule coating forming method comprises magnetic stirring, ultrasonic dispersion and mechanical shearing;
preferably, the amphiphilic block copolymer comprises one or a combination of at least two of tween, span, sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, OP-10.
9. The method according to claim 6, wherein the step (3) of surface-modifying the microcapsule obtained in the step (2) with a functional chemical group comprises: dripping a solution containing functional chemical groups into the product obtained in the step (2) under the stirring state, and continuously stirring for a period of time to obtain the antibacterial and antiviral microcapsule;
preferably, the modification method comprises electrostatic adsorption, ionic adsorption, covalent binding.
10. The use of the antibacterial and antiviral microcapsules of any one of claims 1 to 5 in an antibacterial and antiviral scenario, which includes specific situations of different material surfaces, air flow paths, specific water body types, and the triggering inactivation, slow release inhibition and anti-adhesion effects of the microcapsules are utilized to inactivate target microorganisms;
preferably, the surface of different materials comprises glass, resin, wood, ceramic, stainless steel and leather;
preferably, the air flow path comprises an indoor air filter, a fresh air system;
preferably, the specific water body types comprise swimming zone water bodies (class III), general industrial water zones, recreational water zones (class IV) which are not directly contacted with human bodies, and general landscape requirement water zones (class V).
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