CN114426479A - 一种精制长链二元酸的方法及装置 - Google Patents
一种精制长链二元酸的方法及装置 Download PDFInfo
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- CN114426479A CN114426479A CN202011076063.7A CN202011076063A CN114426479A CN 114426479 A CN114426479 A CN 114426479A CN 202011076063 A CN202011076063 A CN 202011076063A CN 114426479 A CN114426479 A CN 114426479A
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- 238000000034 method Methods 0.000 title claims abstract description 82
- 238000007670 refining Methods 0.000 title claims abstract description 42
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 title claims description 39
- 239000002253 acid Substances 0.000 claims abstract description 134
- 238000001914 filtration Methods 0.000 claims abstract description 64
- 239000000047 product Substances 0.000 claims abstract description 56
- 239000007788 liquid Substances 0.000 claims abstract description 45
- 239000002904 solvent Substances 0.000 claims abstract description 45
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- 238000002425 crystallisation Methods 0.000 claims abstract description 38
- 230000008025 crystallization Effects 0.000 claims abstract description 38
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- 239000012452 mother liquor Substances 0.000 claims abstract description 32
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- 239000003463 adsorbent Substances 0.000 claims abstract description 9
- 238000004064 recycling Methods 0.000 claims abstract description 9
- 239000000706 filtrate Substances 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 238000002156 mixing Methods 0.000 claims description 24
- 238000000855 fermentation Methods 0.000 claims description 19
- 230000004151 fermentation Effects 0.000 claims description 19
- 238000010438 heat treatment Methods 0.000 claims description 15
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 14
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 14
- 238000007599 discharging Methods 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 13
- 239000012065 filter cake Substances 0.000 claims description 13
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 239000012043 crude product Substances 0.000 claims description 6
- 150000007524 organic acids Chemical class 0.000 claims description 4
- 238000003916 acid precipitation Methods 0.000 claims description 3
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 3
- 238000005374 membrane filtration Methods 0.000 claims description 3
- 235000005985 organic acids Nutrition 0.000 claims description 3
- 230000020477 pH reduction Effects 0.000 claims description 3
- 239000012286 potassium permanganate Substances 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000004927 clay Substances 0.000 claims description 2
- 239000000498 cooling water Substances 0.000 claims description 2
- 238000001471 micro-filtration Methods 0.000 claims description 2
- 244000005700 microbiome Species 0.000 claims description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 2
- 238000000108 ultra-filtration Methods 0.000 claims description 2
- 238000011084 recovery Methods 0.000 abstract description 3
- 210000002966 serum Anatomy 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 38
- 239000000203 mixture Substances 0.000 description 21
- 239000012528 membrane Substances 0.000 description 19
- 229910052757 nitrogen Inorganic materials 0.000 description 19
- TVIDDXQYHWJXFK-UHFFFAOYSA-N dodecanedioic acid Chemical compound OC(=O)CCCCCCCCCCC(O)=O TVIDDXQYHWJXFK-UHFFFAOYSA-N 0.000 description 18
- 238000001514 detection method Methods 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 6
- QQHJDPROMQRDLA-UHFFFAOYSA-N hexadecanedioic acid Chemical compound OC(=O)CCCCCCCCCCCCCCC(O)=O QQHJDPROMQRDLA-UHFFFAOYSA-N 0.000 description 6
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- 238000002844 melting Methods 0.000 description 3
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- 230000001502 supplementing effect Effects 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000005708 Sodium hypochlorite Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- 208000035404 Autolysis Diseases 0.000 description 1
- 206010057248 Cell death Diseases 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010364 biochemical engineering Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000003209 petroleum derivative Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000028043 self proteolysis Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010977 unit operation Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (18)
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Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101885657A (zh) * | 2010-07-17 | 2010-11-17 | 天津市化学试剂研究所 | 从废液中回收对称性直链偶数正构烷烃的方法 |
CN103965035A (zh) * | 2013-01-30 | 2014-08-06 | 上海凯赛生物技术研发中心有限公司 | 长链二元酸的精制方法 |
CN105712871A (zh) * | 2014-12-01 | 2016-06-29 | 中国石油化工股份有限公司 | 一种纯化长链二元酸的方法 |
CN105836976A (zh) * | 2016-06-08 | 2016-08-10 | 北京清源创智科技有限公司 | 长链二元烷酸结晶母液的综合处理方法 |
US20170320805A1 (en) * | 2014-12-02 | 2017-11-09 | Dsm Ip Assets B.V. | Process for manufacturing succinic acid from a fermentation broth using nano filtration to purify recycled mother liquor |
CN108003015A (zh) * | 2017-12-23 | 2018-05-08 | 淄博广通化工有限责任公司 | 长碳链二元羧酸的精制提纯方法 |
US9969676B1 (en) * | 2017-06-28 | 2018-05-15 | Vitaworks Ip, Llc | Process for the separation of long chain amino acids and dibasic acids |
US20190202768A1 (en) * | 2016-06-06 | 2019-07-04 | Novamont S.P.A. | Process for the preparation of purified dicarboxylic acids |
CN110054561A (zh) * | 2018-01-18 | 2019-07-26 | 凯赛(乌苏)生物技术有限公司 | 一种长链二元酸的氧化脱色工艺 |
US20190248726A1 (en) * | 2016-07-11 | 2019-08-15 | Cathay R&D Center Co., Ltd. | Solid-solid separation process for long chain dicarboxylic acids |
CN110305006A (zh) * | 2019-06-12 | 2019-10-08 | 江苏达成生物科技有限公司 | 长碳链二元酸提纯精制废液的处理方法 |
CN111392749A (zh) * | 2020-03-26 | 2020-07-10 | 宁夏大学 | 一种从煤化工高盐废水中分质提取高纯度、大颗粒硫酸钠和氯化钠的方法 |
-
2020
- 2020-10-10 CN CN202011076063.7A patent/CN114426479A/zh active Pending
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101885657A (zh) * | 2010-07-17 | 2010-11-17 | 天津市化学试剂研究所 | 从废液中回收对称性直链偶数正构烷烃的方法 |
CN103965035A (zh) * | 2013-01-30 | 2014-08-06 | 上海凯赛生物技术研发中心有限公司 | 长链二元酸的精制方法 |
CN105712871A (zh) * | 2014-12-01 | 2016-06-29 | 中国石油化工股份有限公司 | 一种纯化长链二元酸的方法 |
US20170320805A1 (en) * | 2014-12-02 | 2017-11-09 | Dsm Ip Assets B.V. | Process for manufacturing succinic acid from a fermentation broth using nano filtration to purify recycled mother liquor |
US20190202768A1 (en) * | 2016-06-06 | 2019-07-04 | Novamont S.P.A. | Process for the preparation of purified dicarboxylic acids |
CN105836976A (zh) * | 2016-06-08 | 2016-08-10 | 北京清源创智科技有限公司 | 长链二元烷酸结晶母液的综合处理方法 |
US20190248726A1 (en) * | 2016-07-11 | 2019-08-15 | Cathay R&D Center Co., Ltd. | Solid-solid separation process for long chain dicarboxylic acids |
US9969676B1 (en) * | 2017-06-28 | 2018-05-15 | Vitaworks Ip, Llc | Process for the separation of long chain amino acids and dibasic acids |
CN108003015A (zh) * | 2017-12-23 | 2018-05-08 | 淄博广通化工有限责任公司 | 长碳链二元羧酸的精制提纯方法 |
CN110054561A (zh) * | 2018-01-18 | 2019-07-26 | 凯赛(乌苏)生物技术有限公司 | 一种长链二元酸的氧化脱色工艺 |
CN110305006A (zh) * | 2019-06-12 | 2019-10-08 | 江苏达成生物科技有限公司 | 长碳链二元酸提纯精制废液的处理方法 |
CN111392749A (zh) * | 2020-03-26 | 2020-07-10 | 宁夏大学 | 一种从煤化工高盐废水中分质提取高纯度、大颗粒硫酸钠和氯化钠的方法 |
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Effective date of registration: 20231225 Address after: 100728 No. 22 North Main Street, Chaoyang District, Beijing, Chaoyangmen Applicant after: CHINA PETROLEUM & CHEMICAL Corp. Applicant after: Sinopec (Dalian) Petrochemical Research Institute Co.,Ltd. Address before: 100728 No. 22 North Main Street, Chaoyang District, Beijing, Chaoyangmen Applicant before: CHINA PETROLEUM & CHEMICAL Corp. Applicant before: DALIAN RESEARCH INSTITUTE OF PETROLEUM AND PETROCHEMICALS, SINOPEC Corp. |