CN114403440A - Composition containing eucommia ulmoides with constipation treating effect - Google Patents

Composition containing eucommia ulmoides with constipation treating effect Download PDF

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CN114403440A
CN114403440A CN202210054269.2A CN202210054269A CN114403440A CN 114403440 A CN114403440 A CN 114403440A CN 202210054269 A CN202210054269 A CN 202210054269A CN 114403440 A CN114403440 A CN 114403440A
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parts
eucommia ulmoides
seeds
eucommia
composition
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潘淑勇
高瑞文
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Shandong Beilong Duzhong Biological Engineering Co ltd
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Shandong Beilong Duzhong Biological Engineering Co ltd
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
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    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
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Abstract

The invention belongs to the technical field of compositions containing eucommia ulmoides, and particularly relates to a composition which takes eucommia ulmoides as a raw material and has an excellent constipation relieving effect. The composition mainly comprises: 1-30 parts of eucommia ulmoides; the eucommia bark comprises at least one of eucommia bark, eucommia leaf, eucommia male flower and eucommia seed oil; other raw materials: at least one of moringa leaves, hawthorn, cassia seeds, angelica sinensis, fructus cannabis, bunge cherry seeds, radish seeds, radix polygonati officinalis, orange peel/dried orange peel, mulberry, acanthopanax sessiliflorus, noni fruits, gymnema, xylo-oligosaccharide, oat beta-glucan, galacto-oligosaccharide, inulin, polyfructose, cottonseed oligosaccharide, oligomannose, arabinogalactan, plantago asiatica shells, chia seeds and ampelopsis grossedentata leaves. The composition product provided by the invention has excellent effect of relaxing bowel, and obtains excellent effect through trial of a plurality of constipation patients; the raw materials of the product are taken from medicinal and edible medicinal materials and new food raw materials, so that the safety is high and the side effect is small.

Description

Composition containing eucommia ulmoides with constipation treating effect
Technical Field
The invention belongs to the technical field of compositions containing eucommia ulmoides, and particularly relates to a composition containing eucommia ulmoides and having an effect of treating constipation.
Background
The record of Shennong Ben Cao Jing records that the eucommia bark is pungent and mild in flavor. It is effective in relieving lumbago and gonalgia, invigorating middle warmer, replenishing vital essence, strengthening tendons and bones, and strengthening body. Itching and dampness due to yin deficiency, dribbling urination. It is suitable for long-term administration, and has effects of reducing weight and resisting aging. One of the Chinese herbal medicines, is prepared by mixing eucommia bark, donkey-hide gelatin and ginseng.
The compendium of materia Medica records: xi (more than 2000 years ago) is named because it is obtained by taking eucommia bark. It is indicated for the secondary and emotional reasons. Eucommia bark, cortex Eucommiae, acting as a liver-qi-entering kidney-tonifying, middle-jiao-reinforcing, essence-qi-tonifying, strengthening tendons and bones, will strengthen the mind, and is indicated for lumbago due to kidney deficiency. It is used for a long time, and has effects of reducing weight and resisting aging … … ".
The following patent documents disclose products for regulating the intestines and stomach or loosening the bowel to relieve constipation, which are prepared from eucommia ulmoides as a raw material:
CN109393267A discloses a eucommia ulmoides leaf compound beverage for coordinating intestines and stomach and a preparation method thereof, wherein the compound beverage is prepared by adding purified water into the following materials according to the proportion (mass ratio): 60-70 parts of eucommia ulmoides leaf concentrated solution, 20-30 parts of composite functional concentrated solution, 4-8 parts of trehalose, 1-2 parts of honey, 0.05-0.08 part of citric acid, 0.08-0.12 part of sodium citrate, 0.01-0.02 part of ethyl maltol, 0.05-0.08 part of sodium dehydroacetate, 0.05-0.1 part of sodium hexametaphosphate, 0.03-0.05 part of gellan gum, 0.08-0.12 part of xanthan gum, 0.05-0.1 part of sodium carboxymethylcellulose and 0.03-0.05 part of fruity essence; the compound functional concentrated solution is obtained by soaking and extracting fresh yacon, jujubes, mulberry and burdock in water according to the proportion (mass ratio) of 1:1:1: 2.
The patent documents only mention that the product has better retention rate of flavone and chlorogenic acid, but no relevant data is presented for judging whether the product can relax bowel and achieve ideal effect of conditioning intestines and stomach. Thus, the skilled person is not aware of their main efficacy.
Disclosure of Invention
In order to solve the above technical problems, the present invention provides a composition comprising eucommia ulmoides having excellent therapeutic and prophylactic effects on constipation.
In the process of researching and developing the eucommia ulmoides, the inventor develops a combined formula containing the eucommia ulmoides at one time by chance, so that the constipation relieving effect of the eucommia ulmoides is doubled, and even the constipation is cured. Although the literature in the background art discloses that the eucommia bark has the effect of conditioning the intestines and stomach, relevant data are not seen to support the view point, so that the fact that the eucommia bark can achieve the ideal effect of relaxing the bowels cannot be known.
The invention provides a composition containing eucommia bark and having the function of treating constipation, which mainly comprises the following components:
eucommia ulmoides: the eucommia bark comprises at least one of eucommia bark, eucommia leaf, eucommia male flower and eucommia seed oil;
also comprises other raw materials, wherein the other raw materials are selected from any one of the following raw materials:
moringa oleifera leaf, hawthorn, cassia seed, Chinese angelica, fructus cannabis, bunge cherry seed, radish seed, radix polygonati officinalis, orange peel/dried orange peel, mulberry, acanthopanax sessiliflorus, noni fruit, gymnema, xylooligosaccharide, oat beta-glucan, galactooligosaccharide, inulin, polyfructose, cottonseed oligosaccharide, oligomannose, arabinogalactan, Plantago ovata seed husk, chia seed and Ampelopsis grossedentata leaf.
The eucommia ulmoides is selected from any one of 1-20 parts of eucommia ulmoides bark, 1-30 parts of eucommia ulmoides leaf, 1-10 parts of eucommia ulmoides male flower and 0.5-10 parts of eucommia ulmoides seed oil.
The eucommia ulmoides is selected from any one of 3-10 parts of eucommia ulmoides bark, 6-15 parts of eucommia ulmoides leaf, 2-6 parts of eucommia ulmoides male flower and 1-3 parts of eucommia ulmoides seed oil.
The other raw materials are selected from any one of the following raw materials: 1-30 parts of moringa leaves, 1-50 parts of hawthorn, 1-30 parts of cassia seeds, 1-20 parts of angelica sinensis, 1-30 parts of fructus cannabis, 1-20 parts of bunge cherry seeds, 1-25 parts of radish seeds, 1-25 parts of polygonatum odoratum, 1-20 parts of orange peel/dried orange peel, 1-50 parts of mulberry, 0.5-10 parts of acanthopanax sessiliflorus, 1-50 parts of noni fruits, 1-50 parts of gymnema sylvestre, 1-50 parts of ampelopsis grossedentata leaves, 0.1-10 parts of oat beta-glucan, 1-50 parts of psyllium husk, 1-50 parts of chia seeds, 0.1-10 parts of xylooligosaccharide, 1-30 parts of galacto oligosaccharide, 1-30 parts of inulin, 1-18 parts of polyfructose, 0.1-10 parts of cottonseed oligosaccharide, 0.1-5 parts of oligomannose and 1-30 parts of arabinogalactan.
The other raw materials are selected from any one of the following raw materials: 2-15 parts of moringa leaves, 5-25 parts of hawthorn, 2-15 parts of cassia seeds, 3-12 parts of angelica sinensis, 2-15 parts of fructus cannabis, 2-10 parts of bunge cherry seeds, 2-15 parts of radish seeds, 2-15 parts of polygonatum odoratum, 2-10 parts of orange peel/dried orange peel, 2-25 parts of mulberry, 1-5 parts of acanthopanax sessiliflorus, 2-25 parts of noni fruits, 2-25 parts of gymnema, 2-25 parts of ampelopsis grossedentata leaves, 0.5-5 parts of oat beta-glucan, 2-25 parts of psyllium husk, 2-25 parts of chia seeds, 0.5-5 parts of xylooligosaccharide, 2-15 parts of galactooligosaccharide, 2-15 parts of inulin, 2-9 parts of polyfructose, 0.5-5 parts of raffinose, 0.5-2 parts of oligomannose, 2-15 parts of arabinogalactan
The composition also comprises food additives, wherein the food additives comprise at least one of acidity regulator, sweetener, preservative, antioxidant, excipient and nutrition enhancer.
The preparation method of the composition containing eucommia ulmoides with the effect of treating constipation comprises the following steps:
(1) extracting cortex Eucommiae or folium Eucommiae or male flower of cortex Eucommiae to obtain extractive solution, concentrating, drying, and pulverizing to obtain fine powder of cortex Eucommiae;
(2) mixing the eucommia ulmoides fine powder in the step (1) with other raw materials/extracts of other raw materials, and fully and uniformly stirring; the other raw materials are as follows: at least one of moringa leaves, hawthorn, cassia seeds, angelica sinensis, fructus cannabis, bunge cherry seeds, radish seeds, radix polygonati officinalis, orange peel/dried orange peel, mulberry, acanthopanax sessiliflorus, noni fruits, gymnema, xylo-oligosaccharide, oat beta-glucan, galacto-oligosaccharide, inulin, polyfructose, cottonseed oligosaccharide, oligomannose, arabinogalactan, plantago asiatica shells, chia seeds and ampelopsis grossedentata leaves;
(3) adding food additive or not to obtain composition.
The preparation method of the composition containing eucommia ulmoides with the effect of treating constipation comprises the following steps:
(1) mixing cortex Eucommiae or folium Eucommiae or male flower of cortex Eucommiae with other raw materials, and extracting; the extraction steps are as follows: adding water which is 8-12 times of the total weight of the materials, boiling the mixture in water at 90-100 ℃ for 1-2 hours for extraction, filtering out a primary extracting solution, then adding water which is 8-12 times of the total weight of the materials, boiling the mixture in water at 90-100 ℃ for extraction for 1-2 hours again, extracting the mixture for 2 times, and then combining the extracting solutions;
the materials are eucommia bark and other raw materials;
(2) filtering the extracting solution in the step (1), centrifuging, concentrating, drying until the water content is less than 6%, and crushing to 100 meshes to obtain mixed powder;
(3) adding food additive or not to obtain composition; the other raw materials comprise at least one of moringa leaves, hawthorn, cassia seeds, angelica and fructus cannabis, bunge cherry seeds, radish seeds, radix polygonati officinalis, orange peel/dried orange peel, mulberry, acanthopanax sessiliflorus, noni fruits, gymnocys, xylo-oligosaccharide, oat beta-glucan, galacto-oligosaccharide, inulin, polyfructose, cottonseed oligosaccharide, oligomannose, arabinogalactan, psyllium husk, chia seeds and Ampelopsis grossedentata.
The preparation method of the composition containing eucommia ulmoides with the effect of treating constipation comprises the following steps:
(1) mixing cortex Eucommiae or folium Eucommiae or male flower of cortex Eucommiae with other raw materials, and pulverizing together, or pulverizing respectively and mixing;
the materials are as follows: eucommia ulmoides and other raw materials;
(2) crushing the materials in the step (1) to obtain a crushed particle size of more than 10 meshes;
(3) adding food additive or not to obtain composition; the other raw materials comprise at least one of moringa leaves, hawthorn, cassia seeds, angelica, fructus cannabis, bunge cherry seeds, radish seeds, radix polygonati officinalis, orange peel/dried orange peel, mulberry, acanthopanax sessiliflorus, noni fruits, gymnocys, xylo-oligosaccharide, oat beta-glucan, galacto-oligosaccharide, inulin, polyfructose, cottonseed oligosaccharide, oligomannose, arabinogalactan, psyllium husk, chia seeds and ampelopsis grossedentata.
In the preparation method of the composition containing eucommia ulmoides oliv for treating constipation, the composition in (3) is granulated or not granulated to obtain a granular or powdery composition.
The preparation method of the composition containing eucommia ulmoides for treating constipation is to prepare the composition in the step (3) into any one of solid beverage, liquid beverage, tablet, capsule, instant tea, tablet candy, gel candy and substitute tea.
The composition provided by the invention also comprises a food additive, wherein the food additive comprises at least one of acidity regulator, sweetener, preservative, antioxidant, excipient and nutrition enhancer.
The acidity regulator is at least one selected from citric acid, malic acid, tartaric acid, adipic acid, sodium carbonate, lactic acid, fumaric acid, succinic acid, citrate, and fruit vinegar;
the sweetener is white sugar, fructose, maltitol, isomalt, trehalose, erythritol, idaxine, xylitol, sorbitol, lactitol, mannitol, L-arabinose, L-rhamnose, D-ribose, tagatose, isomaltose, fructo-oligosaccharide, xylo-oligosaccharide, oligomannose, stachyose, raffinose, lactulose, galacto-oligosaccharide, isomaltose-oligosaccharide, gentiooligosaccharide, soybean oligosaccharide, oligochitosan, stevioside, sucralose, mogroside, glucose, sucrose, maltose, lactose, sugar alcohol, glycyrrhizic acid disodium, monopotassium glycyrrhizinate, glycyrrhizic acid trisodium, ammonium glycyrrhizinate, neotame, alitame, thaumatin, aspartame, acesulfame, sodium cyclamate, At least one of saccharin.
The preservative is at least one selected from benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, sodium propionate, nisin, calcium propionate and dehydroacetic acid;
the antioxidant is at least one selected from ascorbic acid, butyl hydroxy anisol, tea polyphenols, propyl gallate, phytic acid, dibutyl hydroxy toluene and propyl gallate;
the excipient is at least one selected from starch, maltodextrin, xanthan gum, carrageenan, konjac gum, konjac flour, sodium carboxymethylcellulose, sesbania gum, tamarind seed gum, gelatin, acacia, sodium caseinate, cyclodextrin, pectin, soybean milk powder, cocoa powder and magnesium stearate;
the nutrition enhancer is selected from: at least one of trace elements, vitamins, calcium lactate, ferrous lactate, and potassium gluconate.
The raw materials adopted in the invention have the following characteristics:
eucommia bark, slightly pungent, warm in nature; entering liver and kidney meridians; tonify liver and kidney, strengthen tendons and bones, prevent miscarriage; can be used for treating deficiency of liver and kidney, soreness of waist and knees, weakness of tendons and bones, dizziness, metrorrhagia during pregnancy, and threatened abortion. Has the obvious effect of lowering blood pressure and the effects of lowering blood fat and blood sugar. Modern science proves that the bark, leaf and flower of eucommia bark have the same effect.
The moringa leaf and moringa leaf powder has the effects of reducing blood sugar, blood fat and blood pressure, resisting tumors, resisting oxidation, relaxing bowels, promoting urination, expelling parasites, improving sleep and the like, and can enhance the immunologic function of a human body, delay aging and prevent diseases after being eaten for a long time. Indian grass medicinally recognizes moringa oleifera as preventing 300 diseases. Particularly, in recent years, the moringa oleifera is concerned and touted by a plurality of research institutions and consumers in developed countries such as Europe and America.
Haw, sour and sweet, slightly warm. It enters spleen, stomach and liver meridians. Promoting digestion and strengthening the stomach, promoting the circulation of qi and dissipating blood stasis, and eliminating turbid pathogen and lowering the blood pressure. Can be used for treating meat stagnation, gastric distention, dysentery, abdominal pain, blood stasis, amenorrhea, puerperal blood stasis, abdominal pain, thoracic obstruction, heart pain, hernia pain, and hyperlipidemia. The charred fructus crataegi has effects of resolving food stagnation. Can be used for treating food stagnation and diarrhea and dysentery.
Cassia seed, semen Cassiae, sweet, bitter, salty and slightly cold. It enters liver and large intestine meridians. Clear heat, improve eyesight, moisten intestines and relax bowels. Can be used for treating conjunctival congestion, photophobia, lacrimation, headache, vertigo, dim eyesight, and constipation.
Dang Gui is sweet, pungent and warm. It enters liver, heart and spleen meridians. Tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation.
Fructus Cannabis, sweet and neutral. It enters spleen, stomach and large intestine meridians. To moisten intestines and relax bowels. Can be used for treating constipation due to intestinal dryness caused by blood deficiency and body fluid deficiency.
Yu Li ren is pungent, bitter, sweet and neutral. It enters spleen, large intestine and small intestine meridians. Moisten intestines to relieve constipation, descend qi to induce diuresis. Can be used for treating consumption of body fluid, intestinal dryness, food stagnation, qi stagnation, abdominal distention, constipation, edema, loempe, and dysuria.
Radish seed, pungent, sweet and neutral. It enters lung, spleen and stomach meridians. Promote digestion, relieve distension, direct qi downward and resolve phlegm. Can be used for treating diet stagnation, abdominal pain, constipation, stagnation, dysentery, phlegm accumulation, and cough and asthma.
Yu Zhu is sweet and slightly cold. It enters lung and stomach meridians. To nourish yin, moisten dryness, promote the production of body fluid and quench thirst. Can be used for treating yin injury of lung and stomach, cough due to dryness-heat, dry throat, thirst, and diabetes due to internal heat.
Chen Pi is bitter, pungent and warm. It enters lung and spleen meridians. Regulate qi to invigorate spleen, dry dampness and resolve phlegm. Can be used for treating distention and fullness of the stomach and abdomen, anorexia, vomiting and diarrhea, cough and excessive phlegm
Mulberry fruit, fructus Mori is sweet and cold in property, and can produce saliva and slake thirst, moisten intestines and relieve constipation, so it can be used for thirst due to body fluid consumption in febrile diseases, diabetes due to internal heat due to yin deficiency, and constipation due to intestinal dryness due to yin deficiency and fluid depletion.
Acanthopanax sessiliflorus fruit belongs to medicine and food homologous food, and the efficacy of the acanthopanax sessiliflorus and the record of fruits and vegetables are recorded in Shennong Ben Cao Jing and Ben Cao gang mu, and praise 'no toxicity'. It is suitable for the elderly after long-term administration, and has difficulty in reaching the effect, and it is used to treat Acanthopanax gracilistylus, not to be used in the whole car. Balancing yin and yang, and entering spleen, kidney and heart meridians; invigorating kidney, strengthening waist, invigorating qi, tranquilizing mind, promoting blood circulation, dredging collaterals, promoting urination, relaxing bowels, and improving immunity.
Morinda citrifolia has effects in regulating intestine and stomach, and regulating digestive system, and can be used for treating gastroenteritis, gastric ulcer, dyspepsia, and constipation.
The euglena and euglena polysaccharide can not be absorbed by human body, and because of the internal porous structure, the euglena and euglena polysaccharide can adsorb redundant substances in the human body, such as cholesterol, neutral fat, heavy metal, alcohol and the like, and discharge the substances out of the body, the euglena and euglena polysaccharide has the functions of strong antioxidation, antivirus and free radical scavenging.
The ampelopsis grossedentata leaves have high content of total flavonoids, and can improve the activity of pepsin and promote intestinal peristalsis.
The oat beta-glucan has the property of water swelling, and can absorb water to swell in the stomach after being eaten by people to generate satiety. In addition, the composition can promote intestinal peristalsis in the intestine, has an osmosis effect in the colon, prevents constipation, shortens the time of waste passing through the intestine, reduces the pollution of carcinogens in the intestine to the intestinal canal, and achieves the effect of cancer prevention.
Plantago ovata forsk, plantain ovata forsk has a large amount of polysaccharide molecules, can absorb a large amount of water, forms paste after absorbing water after entering small intestine, can provide lubrication effect for excrement and intestinal wall, achieves quick defecation effect, and can stimulate the intestinal wall to quickly shrink to help emptying the intestinal tract, so the plantain ovata forsk is often used for promoting defecation and lubricating the intestine.
Modern pharmacological studies of chia seeds and chia seeds show that chia seeds have the effects of controlling blood sugar, reducing cholesterol, promoting defecation and the like.
Xylo-oligosaccharide which can selectively promote the proliferation activity of intestinal bifidobacteria so as to achieve the effect of treating constipation and chronic diarrhea.
The galactooligosaccharide is an excellent nutrient source and effective multiplication factor of beneficial bacteria such as bifidobacterium, lactobacillus acidophilus and the like in human intestinal tracts, can improve the digestion and absorption functions of the human intestinal tracts and has the effect of relaxing the bowels.
Inulin, which is a natural water-soluble dietary fiber, is hardly hydrolyzed and digested by gastric acid and is utilized only in the colon by beneficial microorganisms, thereby improving the intestinal environment. After the inulin is ingested, the gastrointestinal peristalsis can be enhanced, the gastrointestinal function is improved, and the effect of relaxing the bowels is achieved.
Polyfructose is beneficial to the reproduction of bifidobacteria in human intestinal tracts and can play a role in preventing intestinal infection; has effects in controlling blood lipid increase, and preventing cardiovascular and cerebrovascular diseases; inulin with large polymerization degree is not easy to degrade and be absorbed by human body, has certain hypoglycemic effect, and is very suitable for diabetes patients; in addition, inulin, which has a relatively large molecular weight of about 5500Da, is a dietary fiber and has an effect of preventing constipation.
The cottonseed oligosaccharide can simultaneously promote the propagation and growth of beneficial bacteria such as bifidobacterium, lactobacillus and the like, effectively inhibit the propagation of harmful bacteria in intestinal tracts and establish a healthy intestinal tract flora environment; can be used for preventing constipation and diarrhea. Regulating intestine, relaxing bowels, removing toxic substances, and caring skin.
The oligomannose is fermented by bifidobacterium to produce a large amount of short-chain fatty acid which can stimulate intestinal tract peristalsis, improve intestinal tract function, increase feces humidity and keep certain osmotic pressure, thereby preventing constipation.
Arabinogalactan, a natural dietary fiber, is used in combination with traditional medicine to treat chronic or recurrent constipation due to improper diet.
The invention has the beneficial effects that:
(1) the composition product provided by the invention has excellent effect of relaxing bowel, and obtains excellent effect through trial of a plurality of constipation patients; specifically, the data of the taking scheme, the effect and the like of the population of different ages in the embodiment are shown;
(2) the raw materials of the product are taken from medicinal and edible medicinal materials and new food raw materials, and the product has high safety and small side effect.
Drawings
FIG. 1 shows a product of the present invention.
Detailed Description
The present invention will now be further described with reference to specific embodiments in order to enable those skilled in the art to better understand the present invention.
Product formula and preparation process
Example 1
A composition containing eucommia bark with good treatment and prevention effects on constipation mainly comprises eucommia bark, and the specific formula of the composition is as follows:
100g of eucommia bark and 150g of moringa leaves (the above dosage is only the ratio of the small test sample, and the same proportion is enlarged during processing, and the same is applied to the following examples).
The composition is prepared into a tablet candy form, and the specific preparation process comprises the following steps:
extracting cortex Eucommiae and Moringa oleifera leaf respectively to obtain extractive solutions, concentrating, drying, pulverizing, adding dextrin 25%, granulating, and tabletting. (dextrin 25% is based on the weight of the pulverized material, and the following non-references are all by weight percent).
Example 2
A composition containing eucommia bark and having good treatment and prevention effects on constipation mainly comprises eucommia bark, moringa leaves and hawthorn, and the specific formula is as follows:
150g of eucommia bark and 100g of moringa leaves; and 120g of hawthorn.
The composition is prepared into a liquid beverage form by the following specific preparation process:
extracting folium Eucommiae, Moringa oleifera leaf and fructus crataegi respectively to obtain extractive solutions, and concentrating to density of 1.15g/cm3And adding trehalose 5% and purified water to obtain liquid beverage.
Example 3
A composition containing Eucommiae cortex for treating and preventing constipation mainly comprises Eucommiae cortex male flower, Moringa oleifera leaf, fructus crataegi, and semen Cassiae; the specific formula is as follows:
60g of eucommia male flower, 50g of moringa oleifera leaf and 50g of hawthorn; 150g of cassia seed.
The composition is prepared into a capsule form, and the specific preparation process comprises the following steps:
mixing Eucommiae cortex male flower, Moringa oleifera leaf, fructus crataegi and semen Cassiae, micronizing to 300 mesh or more, adding ascorbic acid 200mg for resisting oxidation, and making into capsule.
Example 4
A composition containing Eucommiae cortex for treating and preventing constipation mainly comprises folium Eucommiae, Moringa oleifera leaf, fructus crataegi, semen Cassiae, and radix Angelicae sinensis; the specific formula is as follows:
50g of eucommia leaves, 20g of moringa leaves, 20g of hawthorn and 100g of cassia seeds; 80g of Chinese angelica.
The composition is prepared into a solid beverage form, and the specific preparation process comprises the following steps:
mixing folium Eucommiae, folium Moringae, fructus crataegi, semen Cassiae, and radix Angelicae sinensis, extracting with water, concentrating, spray drying, adding L-arabinose 10%, and making into solid beverage. The extraction, concentration and spray drying are all conventional technical means, and specific process conditions are not listed.
Examples 5 to 7A composition containing eucommia ulmoides having excellent therapeutic and preventive effects on constipation, which comprises the following specific formulation:
Figure BDA0003475756630000111
the composition is prepared into a tablet candy form, and the specific preparation process comprises the following steps:
extracting the raw materials in the formula respectively to obtain extracting solutions, concentrating, drying, crushing, adding food additives, granulating and tabletting;
the above food additives are based on the weight ratio of the formulation.
Example 8
A composition containing Eucommiae cortex for treating and preventing constipation mainly comprises folium Eucommiae, Moringa oleifera leaf, fructus crataegi, semen Cassiae, and radix Angelicae sinensis; the specific formula is as follows:
50g of eucommia leaves, 20g of moringa leaves, 20g of hawthorn, 100g of cassia seeds, 80g of angelica, 30g of acanthopanax sessiliflorus, 10g of noni fruits, 20g of euglena and 250g of ampelopsis grossedentata leaves.
The composition is prepared into a form of substitutional tea, and the specific preparation process comprises the following steps:
pulverizing folium Eucommiae, folium Moringae, fructus crataegi, semen Cassiae, radix Angelicae sinensis, radix Acanthopanacis Senticosi, noni fruit, Euglena, and Ampelopsis grossedentata to 10-50 mesh, mixing, and packaging.
Examples 9 to 12
A composition containing eucommia bark and having good treatment and prevention effects on constipation comprises the following specific formula:
Figure BDA0003475756630000121
Figure BDA0003475756630000131
the composition is prepared into a liquid beverage form by the following specific preparation process:
extracting the raw materials in the formula respectively to obtain extractive solutions, and concentrating to density of 1.15g/cm3Adding food additive and purified water to obtain liquid beverage;
the above food additives are based on the weight ratio of the formulation.
Examples 13 to 15
A composition containing eucommia bark and having good treatment and prevention effects on constipation comprises the following specific formula:
Figure BDA0003475756630000132
Figure BDA0003475756630000141
the composition is prepared into a capsule form, and the specific preparation process comprises the following steps:
mixing the raw materials in the formula, extracting with water, concentrating, spray drying, adding food additive, and making into capsule; the above food additives are based on the weight ratio of the formulation.
Examples 16 to 18
A composition containing eucommia bark and having good treatment and prevention effects on constipation comprises the following specific formula:
Figure BDA0003475756630000142
Figure BDA0003475756630000151
the composition is prepared into a solid beverage form, and the specific preparation process comprises the following steps:
mixing the above materials, extracting with water, concentrating, spray drying, adding food additive, and making into solid beverage;
the above food additives are based on the weight ratio of the formulation.
Example 19
Folium Eucommiae extract. Extracting folium Eucommiae with water, concentrating, spray drying, adding tagatose 20%, and making into solid beverage.
II, effect verification experiment:
1. the test results of volunteer trial experiments on the product of the invention show that the total effective rate of the product of the invention is about 90%.
The method comprises the following specific steps:
the applicant collects volunteers of constipation patients and verifies the effect of the product through a crowd trial experiment.
Grouping volunteers: study group 10 men and 10 women; the age is 27-89 years, and the average age is 59.57 +/-5.59 years. Control group 10 men and 10 women; the age is 25-88 years, and the average age (60.28 +/-4.13) years. The difference between the two groups in terms of gender, age and disease course is not statistically significant (P > 0.05).
The taking method comprises the following steps: study groups received the product of examples 1-18 2 times daily, 6 grams each time; the control group was administered the product of example 19. The food is prohibited from being eaten with spicy, stimulating, high-fat and high-protein food.
Observation indexes are as follows: two groups were compared for clinical efficacy after 16 weeks of treatment. And (3) healing: the defecation time, the stool quality and the defecation labor intensity are recovered to normal or pre-disease level, and other symptoms such as abdominal pain, abdominal distension, fatigue and the like basically disappear for more than 2 weeks; the effect is shown: the defecation time, the defecation frequency and the defecation labor intensity are obviously improved compared with those before treatment, and other symptoms are also obviously improved for more than 2 weeks; the method has the following advantages: the defecation interval is shortened by 1d, the defecation labor intensity is improved compared with the prior art, and other symptoms are improved for 2 weeks; and (4) invalidation: the above standards are not met. Total effective rate (cure + significant effect + effective)/total number of cases x 100%. In addition, evaluation is carried out on the stool properties by adopting Bristol stool property integral, the score is 0-3, and the higher the score is, the worse the stool properties are.
The statistical method comprises the following steps: analyzing and processing data by SPSS19.0 software, and measuring data by mean +/-standard deviation
Figure BDA0003475756630000161
Indicating, and checking a line t; the count data is expressed in percent (%), column x2And (6) checking. P <0.05 indicates that the difference is statistically significant.
TABLE 1 comparison of two treatment results [ n (%) ]
Figure BDA0003475756630000162
Figure BDA0003475756630000171
TABLE 2 comparison of the score for the fecal traits of the two Bristol groups: (
Figure BDA0003475756630000172
Minute)
Figure BDA0003475756630000173
Note: p <0.05 compared to pre-treatment.
And (4) conclusion:
(1) the total effective rate of the research group is higher than that of the control group. The eucommia bark composition has better curative effect than the non-composition.
(2) After treatment, the fecal character scores of both groups of Bristol are reduced, but the level of the research group is lower (P is less than 0.05), and the fecal character is better. The eucommia ulmoides composition has better effect of improving the intestinal function.
2. Detailed description of the preferred embodiment
Case 1: mapo, 70 years old, taking western medicine for constipation for 1 year, defecation once every 5 days, taking formula No. 1, 2 times a day, 6 grams each time, healing in 1 week, and defecation 1 time every 1 day. The tracking is continued for 5 months without recurrence. Formulation No. 1 is the product of example 1 (hereinafter, formulation No. 2 is the product of example 2, and so on).
Case 2: wife, 89 years old, constipation 5 years old, defecation once in 4 days, taking formula No. 4, 2 times a day, 6 grams each time, recovery in 1 month, and defecation 1 time in 1 day. The tracking was continued for 4 months without recurrence.
Case 3: mr. Li, 56 years old, constipation 10 years old, 5 days once stool, sticky, take No. 7 prescription, 2 times a day, 6 grams each time, 2 months fully recover, 1 time of stool 1 day. The tracking is continued for 3 months without recurrence.
Case 4: for a lady, 41 years old, constipation lasts for 20 years, and stools are performed once in 5 days, and after taking the formula No. 10, 2 times a day and 6 g each time, the patient can be healed in 3 months, and stools are performed 1 time in 1 day. The tracking is continued for 2 months without recurrence.
Case 5: the No. 14 formula is taken by a woman in 55 years old with constipation for 50 years and excrement for 4 days, 0.5-1 hour each time, 2 times a day and 6 grams each time, the disease is cured in 4 months, and the excrement is 1 time in 1 day. The tracking is continued for 1 month without recurrence.
Case 6: pengpo, 82 years old, suffers from 24 years old, suffers from constipation due to spleen excision 24 years ago, gradually develops into severe constipation and intestinal obstruction, requires large enema once every month in a hospital, costs 5000 yuan, and can be blocked without purgation when a compound glycol electrolyte small enema is taken every 5 days, accompanied by symptoms of nausea, belching, epigastric discomfort, abdominal pain and the like, and is bitter and incomparable. The prescription No. 18 is taken 2 times a day, 6 g is taken each time, constipation is gradually relieved in 2 months, enema treatment is eliminated in 4 months, and excrement is defecated 1 time in 1 day.
Case 7: yao lady, 32 years old, constipation 4 months, 3 days big stool. The formula 19 is taken 2 times a day, 6 g each time, the improvement is gradually carried out in 4 months, the patient can not stop taking the formula 19 continuously, and the excrement is taken 1 time in 1 day.
To summarize:
(1) case 7 shows that eucommia bark has the function of relaxing bowels, but the cure rate is very low.
(2) In cases 1-5, patients with constipation can be cured, which shows that the prescription obviously enhances the function of relieving constipation of eucommia, can relieve constipation and greatly improves the cure rate.
(3) Case 6 patients can get rid of enema treatment, which shows that the prescription has obvious curative effect on patients with severe intestinal obstruction after spleen excision.
The examples of the present invention are merely illustrative of several forms of products, but are not limited to the above forms of products, and other forms of products, such as gel candy, tablet, instant tea, etc., are within the scope of the present invention. However, any product that is related to the formulation of the present invention is within the scope of the present invention.
Of course, the food additives listed in the present invention may also be other common food additives, and if the main formula of the present invention is used, only the food additives are replaced, and such modifications also fall within the protection scope of the present invention.

Claims (10)

1. A composition containing eucommia ulmoides with an effect of treating constipation is characterized by mainly comprising the following components:
eucommia ulmoides: the eucommia bark comprises at least one of eucommia bark, eucommia leaf, eucommia male flower and eucommia seed oil;
the feed also comprises other raw materials, and the other raw materials are selected from at least one of the following raw materials:
moringa oleifera leaf, hawthorn, cassia seed, Chinese angelica, fructus cannabis, bunge cherry seed, radish seed, radix polygonati officinalis, orange peel/dried orange peel, mulberry, acanthopanax sessiliflorus, noni fruit, gymnema, xylooligosaccharide, oat beta-glucan, galactooligosaccharide, inulin, polyfructose, cottonseed oligosaccharide, oligomannose, arabinogalactan, Plantago ovata seed husk, chia seed and Ampelopsis grossedentata leaf.
2. The composition for treating constipation according to claim 1, wherein the eucommia ulmoides is at least one selected from the group consisting of 1 to 20 parts of eucommia ulmoides bark, 1 to 30 parts of eucommia ulmoides leaf, 1 to 10 parts of eucommia ulmoides male flower, and 0.5 to 10 parts of eucommia ulmoides seed oil.
3. The composition for treating constipation according to claim 1, wherein the eucommia ulmoides is at least one selected from the group consisting of 3 to 10 parts of eucommia ulmoides bark, 6 to 15 parts of eucommia ulmoides leaf, 2 to 6 parts of eucommia ulmoides male flower, and 1 to 3 parts of eucommia ulmoides seed oil.
4. The composition comprising eucommia ulmoides as claimed in claim 1, wherein the other materials are at least one selected from the group consisting of: 1-30 parts of moringa leaves, 1-50 parts of hawthorn, 1-30 parts of cassia seeds, 1-20 parts of angelica sinensis, 1-30 parts of fructus cannabis, 1-20 parts of bunge cherry seeds, 1-25 parts of radish seeds, 1-25 parts of polygonatum odoratum, 1-20 parts of orange peel/dried orange peel, 1-50 parts of mulberry, 0.5-10 parts of acanthopanax sessiliflorus, 1-50 parts of noni fruits, 1-50 parts of euglena, 0.1-10 parts of xylooligosaccharide, 0.1-10 parts of oat beta-glucan, 1-30 parts of galacto-oligosaccharide, 1-30 parts of inulin, 1-18 parts of polyfructose, 0.1-10 parts of raffinose, 0.1-5 parts of oligomannose, 1-30 parts of arabinogalactan, 1-50 parts of psyllium husk, 1-50 parts of chia seeds and 1-50 parts of Ampelopsis grossedentata leaves.
5. The composition comprising eucommia ulmoides as claimed in claim 1, wherein the other materials are at least one selected from the group consisting of: 2-15 parts of moringa leaves, 5-12 parts of hawthorn, 2-15 parts of cassia seeds, 3-12 parts of angelica sinensis, 1-30 parts of fructus cannabis, 1-20 parts of bunge cherry seeds, 1-25 parts of radish seeds, 1-25 parts of polygonatum odoratum, 1-20 parts of orange peel/dried orange peel, 2-25 parts of mulberry, 1-4.5 parts of acanthopanax sessiliflorus, 2-25 parts of noni fruits, 1-50 parts of gymnema sylvestre, 2-25 parts of ampelopsis grossedentata leaves, 0.5-5 parts of oat beta-glucan, 2-25 parts of psyllium husk, 2-25 parts of chia seeds, 0.5-5 parts of xylooligosaccharide, 2-15 parts of galacto oligosaccharide, 2-15 parts of inulin, 2-9 parts of polyfructose, 0.5-5 parts of cottonseed oligosaccharide, 0.5-2 parts of oligomannose and 2-15 parts of arabinogalactan.
6. The composition comprising eucommia ulmoides oliv for treating constipation according to claim 1, wherein food additives including at least one of acidity regulator, sweetener, preservative, antioxidant, excipient, and fortifier are optionally included in the composition.
7. The method for preparing the composition comprising eucommia ulmoides oliv for treating constipation according to claim 1, comprising the steps of:
(1) extracting cortex Eucommiae or folium Eucommiae or male flower of cortex Eucommiae to obtain extractive solution, concentrating, drying, and pulverizing to obtain fine powder of cortex Eucommiae;
(2) mixing the eucommia ulmoides fine powder in the step (1) with other raw materials/extracts of other raw materials, and fully and uniformly stirring; the other raw materials are as follows: at least one of moringa leaves, hawthorn, cassia seeds, angelica sinensis, fructus cannabis, bunge cherry seeds, radish seeds, radix polygonati officinalis, orange peel/dried orange peel, mulberry, acanthopanax sessiliflorus, noni fruits, gymnema, xylo-oligosaccharide, oat beta-glucan, galacto-oligosaccharide, inulin, polyfructose, cottonseed oligosaccharide, oligomannose, arabinogalactan, plantago asiatica shells, chia seeds and ampelopsis grossedentata leaves;
(3) adding food additive or not to obtain composition.
8. The method for preparing the composition comprising eucommia ulmoides oliv for treating constipation according to claim 1, comprising the steps of:
(1) mixing cortex Eucommiae or folium Eucommiae or male flower of cortex Eucommiae with other raw materials, and extracting; the extraction steps are as follows: adding water which is 8-12 times of the total weight of the materials, boiling the mixture in water at 90-100 ℃ for 1-2 hours for extraction, filtering out a primary extracting solution, then adding water which is 8-12 times of the total weight of the materials, boiling the mixture in water at 90-100 ℃ for extraction for 1-2 hours again, extracting the mixture for 2 times, and then combining the extracting solutions;
the materials are as follows: eucommia ulmoides and other raw materials;
(2) filtering the extracting solution in the step (1), centrifuging, concentrating, drying until the moisture content is less than 6%, and crushing to more than 80 meshes to obtain mixed powder;
(3) adding food additive or not to obtain composition; the other raw materials comprise at least one of moringa leaves, hawthorn, cassia seeds, angelica, fructus cannabis, bunge cherry seeds, radish seeds, radix polygonati officinalis, orange peel/dried orange peel, mulberry, acanthopanax sessiliflorus, noni fruits, gymnocys, xylo-oligosaccharide, oat beta-glucan, galacto-oligosaccharide, inulin, polyfructose, cottonseed oligosaccharide, oligomannose, arabinogalactan, psyllium husk, chia seeds and ampelopsis grossedentata.
9. The method for preparing the composition comprising eucommia ulmoides oliv for treating constipation according to claim 1, comprising the steps of:
(1) mixing cortex Eucommiae or folium Eucommiae or male flower of cortex Eucommiae with other raw materials, and pulverizing together, or pulverizing respectively and mixing;
the materials are as follows: eucommia ulmoides and other raw materials;
(2) crushing the materials in the step (1) to obtain a crushed particle size of more than 10 meshes;
(3) adding food additive or not to obtain composition; the other raw materials comprise at least one of moringa leaves, hawthorn, cassia seeds, angelica, fructus cannabis, bunge cherry seeds, radish seeds, radix polygonati officinalis, orange peel/dried orange peel, mulberry, acanthopanax sessiliflorus, noni fruits, gymnocys, xylo-oligosaccharide, oat beta-glucan, galacto-oligosaccharide, inulin, polyfructose, cottonseed oligosaccharide, oligomannose, arabinogalactan, psyllium husk, chia seeds and ampelopsis grossedentata.
10. The method for preparing a composition comprising eucommia ulmoides as set forth in claims 7, 8 and 9 for treating constipation, wherein: the composition product is granulated or not granulated to obtain a final product; the final product dosage form prepared by the composition product is at least one of solid beverage, liquid beverage, tablet, capsule, instant tea, tablet candy, gel candy and substitute tea.
CN202210054269.2A 2022-01-18 2022-01-18 Composition containing eucommia ulmoides with constipation treating effect Pending CN114403440A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103860817A (en) * 2012-12-13 2014-06-18 湖北老龙洞杜仲开发有限公司 Eucommia compound preparation for treating chronic constipation
CN104922216A (en) * 2014-03-22 2015-09-23 绿之韵生物工程集团有限公司 Bowel-relaxing pharmaceutical composition and preparation method thereof
CN105106588A (en) * 2015-07-16 2015-12-02 朱新华 Traditional Chinese medicinal composition for effectively treating constipation
CN105998594A (en) * 2016-06-27 2016-10-12 吕伟 Medicine for treating habitual constipation
CN111298021A (en) * 2020-04-07 2020-06-19 湖南中医药大学第一附属医院((中医临床研究所)) Traditional Chinese medicine composition for treating functional constipation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103860817A (en) * 2012-12-13 2014-06-18 湖北老龙洞杜仲开发有限公司 Eucommia compound preparation for treating chronic constipation
CN104922216A (en) * 2014-03-22 2015-09-23 绿之韵生物工程集团有限公司 Bowel-relaxing pharmaceutical composition and preparation method thereof
CN105106588A (en) * 2015-07-16 2015-12-02 朱新华 Traditional Chinese medicinal composition for effectively treating constipation
CN105998594A (en) * 2016-06-27 2016-10-12 吕伟 Medicine for treating habitual constipation
CN111298021A (en) * 2020-04-07 2020-06-19 湖南中医药大学第一附属医院((中医临床研究所)) Traditional Chinese medicine composition for treating functional constipation

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