CN114392238A - Freeze-dried preparation for oral care, oral care product and tooth rinsing device - Google Patents
Freeze-dried preparation for oral care, oral care product and tooth rinsing device Download PDFInfo
- Publication number
- CN114392238A CN114392238A CN202111669826.3A CN202111669826A CN114392238A CN 114392238 A CN114392238 A CN 114392238A CN 202111669826 A CN202111669826 A CN 202111669826A CN 114392238 A CN114392238 A CN 114392238A
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- China
- Prior art keywords
- lyophilized formulation
- active ingredient
- parts
- freeze
- weight
- Prior art date
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- Pending
Links
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
- A61C17/02—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A—HUMAN NECESSITIES
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Abstract
The invention discloses a freeze-dried preparation for oral care, an oral care product and a tooth flusher. Wherein the lyophilized preparation comprises: the dental plaque-preventing and/or dental tissue-damaging agent comprises 3-10 parts by weight of an active ingredient, 10-60 parts by weight of a hydrophilic agent and 1-30 parts by weight of a binder, wherein the active ingredient comprises at least one selected from a first active ingredient, a second active ingredient and a third active ingredient, the first active ingredient is an active substance for preventing and/or treating dentin damage, the second active ingredient is an active substance for preventing and/or treating dental plaque generation, and the third active ingredient is an active substance for preventing and/or treating periodontal tissue inflammation and/or dental tissue damage. The freeze-dried preparation can achieve better instant dissolution effect and nursing effect, is convenient to store, carry and take, can be quickly dissolved in water and other solutions when in use, fully flows to the oral cavity everywhere through the good flowing effect, forms sufficient nursing effect, and can be matched with oral care products such as tooth rinsing devices for use.
Description
Technical Field
The invention belongs to the technical field of oral products, and particularly relates to a freeze-dried preparation for oral care, an oral care product and a tooth rinsing device.
Background
With the improvement of living standard and the promotion of oral care consciousness, consumers' appeal for oral care is more and more diversified, and the demands of consumers for products related to the appeal, including toothpaste, toothbrush, tooth whitening products, dental floss and the like, are increasing. At present, the mainstream of oral products is still focused on the toothbrush and toothpaste to play a cleaning function on the surfaces of oral teeth, wherein the toothpaste can generate a large amount of foam when in use, the foam is driven to all places of the teeth by the toothbrush, and the nursing effect on gums and teeth gaps is poor due to poor foam flowability. In addition, there is a possibility that substances which are difficult to dissolve in a care agent such as toothpaste may cause a problem that an active substance exerting a care effect is not easily applied directly to periodontal sites, and there is a possibility that the active substance in the care agent is rapidly lost due to rapid metabolism of saliva in the oral cavity. In view of this, there remains a need for further improvements in existing oral care products.
Disclosure of Invention
The present invention is directed to solving, at least to some extent, one of the technical problems in the related art. Therefore, an object of the present invention is to provide a freeze-dried preparation for oral care, an oral care product and a tooth rinsing device, wherein the freeze-dried preparation can be rapidly dissolved in water and other solutions, and is convenient to carry and take, and the solution can sufficiently flow to various parts of the oral cavity with a good flowing effect during use, so as to form a sufficient care effect, and can be used with the oral care product such as the tooth rinsing device.
In one aspect of the invention, a lyophilized formulation for oral care is provided. According to an embodiment of the invention, the lyophilized formulation comprises: the composition comprises 3-10 parts by weight of active ingredients, 10-60 parts by weight of hydrophilic agents and 1-30 parts by weight of binding agents, wherein the active ingredients comprise at least one selected from a first active ingredient, a second active ingredient and a third active ingredient, the first active ingredient is an active substance for preventing and/or treating dentin damage, the second active ingredient is an active substance for preventing and/or treating dental plaque generation, and the third active ingredient is an active substance for preventing and/or treating periodontal tissue inflammation and/or dental tissue damage.
According to the freeze-dried preparation for oral care in the embodiment of the invention, by controlling the proportion of the freeze-dried preparation to the components, the composition of the active ingredients can be selected according to actual needs such as the disease stage of periodontal disease, so that the freeze-dried preparation has a targeted positive effect on prevention and control of different periodontal diseases, and the loss of the active ingredients can be reduced by adopting the freeze-dried preparation, and the selection range of the freeze-dried preparation on the selectable active ingredients can be widened. Simultaneously, this product of making by freeze-drying process can also reach better instant effect and nursing effect, can dissolve in solution such as water fast, and portable, the solution is taken conveniently, can make active ingredient fully flow everywhere to the oral cavity with its good flow effect during the use, form abundant nursing effect, at portable oral care agent, oral care product fields such as tooth flushing device have extensive application prospect, for example can arrange tooth flushing device and use, utilize tooth flushing device can further send the accurate pump of active ingredient to the oral cavity everywhere, and this freeze-drying preparation can disintegrate fast, can not block up tooth flushing device's pump liquid pipeline or at the inside scale deposit of tooth flushing device water tank because of dissolving inadequately.
In addition, the lyophilized formulation for oral care according to the above embodiment of the present invention may also have the following additional technical features:
in some embodiments of the invention, the hydrophilic agent comprises at least one selected from mannitol, sucrose, maltodextrin, polyethylene glycol and polypropylene glycol.
In some embodiments of the invention, the binder comprises at least one member selected from the group consisting of hydroxyethyl starch, sodium alginate, methyl cellulose, gelatin, gum arabic, xanthan gum, gellan gum, sclerotium rolfsii gum, pullulan, and carob gum.
In some embodiments of the invention, the first active ingredient comprises at least one selected from the group consisting of hydroxyapatite, sodium fluoride, calcium lactate, milk extract and sugar alcohols.
In some embodiments of the invention, the sugar alcohol comprises at least one selected from sucralose, xylitol, and sorbitol.
In some embodiments of the invention, the second active ingredient comprises at least one selected from the group consisting of a probiotic, an antimicrobial peptide, an immunoglobulin, and a cationic antiseptic.
In some embodiments of the invention, the cationic biocide comprises chlorhexidine and/or cetylpyridinium chloride.
In some embodiments of the invention, the third active ingredient comprises at least one selected from the group consisting of plant extracts, glucosylrutin, tetrapeptide-30, copper peptide, hyaluronic acid, niacinamide, ascorbic acid, and chitin.
In some embodiments of the invention, the botanical extract comprises at least one selected from the group consisting of licorice extract, hypericum perforatum/leaf/stem extract, reed extract, poria cocos extract, fennel extract, hops extract, melissa extract, mistletoe leaf extract and bunge auriculate root extract.
In some embodiments of the present invention, the lyophilized formulation for oral care further comprises 0.1 to 5 parts by weight of a hydrophobic modifier.
In some embodiments of the invention, the hydrophobic modifier comprises at least one selected from the group consisting of triglycerides, fatty alcohol sulfates, fatty alcohol polyether sulfates, fatty acyl glutamates, alkyl glucosides, betaines, fatty acyl taurates, and fatty acyl methyl taurates.
In some embodiments of the present invention, the lyophilized formulation for oral care further comprises not more than 2 parts by weight of an adjuvant including at least one selected from the group consisting of a flavoring agent, a food coloring agent, and a moisture-proof agent.
In some embodiments of the invention, preparing the lyophilized liquid of the lyophilized formulation comprises: 45-80 parts by weight of water or an aqueous solution.
In some embodiments of the invention, the lyophilization liquid comprises: 4-8 parts by weight of the active ingredient, 15-40 parts by weight of the hydrophilic agent, 2-7 parts by weight of the binder and 45-80 parts by weight of water.
In some embodiments of the invention, the freeze-drying pressure of the freeze-dried formulation is between 0.2MPa and 1.0 MPa.
In some embodiments of the invention, the lyophilized formulation is a block having a mass of 0.2g to 2.0g, and/or the lyophilized formulation is a pill or tablet having a size of no greater than 20mm in any direction.
According to yet another aspect of the invention, an oral care product is provided. According to an embodiment of the present invention, the oral care product comprises the above-described lyophilized formulation for oral care. Therefore, the characteristics and effects described for the above lyophilized preparation for oral care are also applicable to the oral care product, and are not described in detail herein. In general, the oral care product can realize the synergy of the self inherent function and the functions of preventing and treating the periodontal disease, and can also adapt freeze-dried preparations with different active ingredients according to the actual oral conditions of different periodontal disease users, thereby realizing the targeted care aiming at different stages of the periodontal disease development.
According to yet another aspect of the present invention, the present invention provides a dental irrigator. According to an embodiment of the invention, the dental irrigator comprises: the main machine is internally provided with a liquid pumping assembly; the water tank is used for containing liquid and is communicated with the liquid pumping assembly; the nozzle is connected with the host and communicated with the liquid pumping assembly, and when the liquid pumping assembly works, liquid in the water tank is pumped to the nozzle and is sprayed out of the nozzle; wherein at least one of the main machine or the water tank is provided with a charging opening, the charging opening is used for charging freeze-dried preparation into the water tank, the freeze-dried preparation can be dissolved in the liquid in the water tank, and the freeze-dried preparation comprises the freeze-dried preparation for oral care. Compared with the prior art, the tooth flusher can be matched with the freeze-dried preparation for use, wherein the freeze-dried preparation has the remarkable advantage of high rehydration and dissolution speed, can be matched with the tooth flusher for use and can be quickly dissolved in water, the tooth flusher cannot be blocked, dirt which is difficult to clean cannot be formed on the inner wall of a water tank, and active ingredients for treating and preventing periodontal diseases can be directly delivered to the deep part of a tooth gap or even a periodontal disease along with water flow.
In some embodiments of the invention, the feed opening is located on the water tank, and the smallest dimension of the opening of the feed opening is not less than 10 mm.
In some embodiments of the present invention, the tooth flusher further comprises a pump liquid pipe for communicating the water tank with the pump liquid assembly, and a filter screen is arranged on the pump liquid pipe.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
fig. 1 is a schematic structural view of a dental irrigator according to one embodiment of the present invention.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.
In one aspect of the invention, a lyophilized formulation for oral care is provided. According to an embodiment of the invention, the lyophilized formulation comprises: the composition comprises 3-10 parts by weight of active ingredients (for example, 5 parts, 7 parts or 9 parts), 10-60 parts by weight of hydrophilic agents (for example, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts or 55 parts), and 1-30 parts by weight of binding agents (for example, 3 parts, 5 parts, 8 parts, 10 parts, 15 parts, 20 parts or 25 parts), wherein the active ingredients comprise at least one selected from a first active ingredient, a second active ingredient and a third active ingredient, the first active ingredient is an active substance for preventing and/or treating dentin damage, the second active ingredient is an active substance for preventing and/or treating dental plaque generation, and the third active ingredient is an active substance for preventing and/or treating inflammation of periodontal tissues and/or damage of dental tissues.
The inventor finds that the freeze drying causes less damage to substances, especially the loss of heat-sensitive nutritional factors in the drying process is less than that of the heat treatment process for the drying purpose, the biological activity of related natural source components can be ensured to the maximum extent, and the loss of the component activity caused in the production process can be reduced; furthermore, due to the lack of moisture in the lyophilized formulation, the possibility of contamination of the product by microorganisms and related pathogens is minimized, which may increase the shelf life of the product and reduce the quality risk of the product to some extent. Moreover, the freeze-dried preparation can form microscopic pores due to sublimation of ice crystals in the freeze-dried process, so that the freeze-dried preparation can be rehydrated (recombined) more quickly and easily, the advantage of rehydration and dissolution in water is obvious, the dissolution effect is good, the active ingredients can be better applied to periodontal sites, and the loss of the active ingredients due to overlong retention time of the active ingredients in the oral cavity can be avoided. In addition, under the current daily care scene, the related oral care modes provided for different periodontal disease onset stages are mostly the same, the general care mode can cause further deterioration of the disease condition of a patient, and the composition of the active ingredients can be flexibly selected according to actual conditions by adopting the freeze-dried preparation of the invention.
In conclusion, according to the embodiment of the application, by controlling the ratio of the components of the freeze-dried preparation, the composition of the active ingredients can be selected according to actual needs such as the onset stage of the periodontal disease, so that the freeze-dried preparation has a targeted positive effect on prevention and treatment of different periodontal diseases, and the loss of the active ingredients can be reduced by adopting the freeze-dried preparation, and the selection range of the freeze-dried preparation on the selectable active ingredients can be widened. Simultaneously, this product of making by freeze-drying process can also reach better instant effect and nursing effect, can dissolve in solution such as water fast, and portable, the solution is taken conveniently, can make active ingredient fully flow everywhere to the oral cavity with its good flow effect during the use, form abundant nursing effect, at portable oral care agent, oral care product fields such as tooth flushing device have extensive application prospect, for example can arrange tooth flushing device and use, utilize tooth flushing device can further send the accurate pump of active ingredient to the oral cavity everywhere, and this freeze-drying preparation can disintegrate fast, can not block up tooth flushing device's pump liquid pipeline or at the inside scale deposit of tooth flushing device water tank because of dissolving inadequately.
The lyophilized formulation for oral care according to the above embodiment of the present invention will be described in detail below.
According to the embodiment of the invention, the inventor finds that the rapid disintegration effect of the freeze-dried preparation can be realized by increasing the proportion of the water-absorbing components, wherein a large amount of hydrophilic factors are rapidly lost in the freeze-drying process, so that the formation of a hydrated micro-molecular microporous structure is facilitated, and the better instant dissolution effect of the freeze-dried preparation can be ensured by controlling the dosage range of the hydrophilic agent in the freeze-dried preparation. Preferably, the amount of the hydrophilic agent used in preparing the lyophilized preparation may be 15 to 40 parts by weight or 15 to 20 parts by weight, etc., based on 100 parts by weight of the lyophilized liquid, whereby the dissolution rate and dissolution effect of the lyophilized preparation in water may be further improved. In addition, it should be noted that the kind of the hydrophilic agent in the present invention is not particularly limited, and may be selected by those skilled in the art according to actual needs, for example, the hydrophilic agent may include, but is not limited to, at least one selected from mannitol, sucrose, maltodextrin, polyethylene glycol, and polypropylene glycol.
According to the embodiments of the present invention, the inventors have found that a binder may be added to a lyophilized preparation in order to provide the lyophilized preparation with certain mechanical properties and physical hardness while maintaining its rapid disintegration properties, wherein the binder may be added in an amount of 1 to 30 parts by weight, such as 2 to 10 parts by weight, based on 100 parts by weight of a lyophilized solution, preferably, the lyophilized preparation may be prepared by controlling the addition amount of the binder in the lyophilized preparation according to the present invention so as to provide the lyophilized preparation with good mechanical properties and physical properties without affecting the instant dissolution effect of the lyophilized preparation. In addition, it should be noted that the kind of the binder in the present invention is not particularly limited, and may be selected by those skilled in the art according to actual needs, and for example, the binder may include, but is not limited to, at least one selected from the group consisting of hydroxyethyl starch, sodium alginate, methyl cellulose, gelatin, gum arabic, xanthan gum, gellan gum, sclerotium rolfsii gum, pullulan and carob gum.
According to the embodiment of the invention, different active substance choices can be provided according to the actual conditions of different periodontal disease users, and the instant dissolution rate of the freeze-dried preparation is greatly improved. Wherein, the different periodontitis development stages refer to one or more of dentin damage, dental plaque formation, inflammation of periodontal tissues and damage of periodontal tissues. The inventors have found that the first active ingredient for use in the dentin damage stage may comprise one or a combination of several selected from hydroxyapatite, sodium fluoride, calcium lactate, milk extract, sugar alcohol, thereby achieving a certain preventive or therapeutic effect against problems such as dental calculus, enamel damage and caries. The second active ingredient used in the generation stage of dental plaque can comprise one or a combination of probiotics, antibacterial peptide, immunoglobulin and cationic bactericide, so that the microbial environment in the oral cavity can be improved, beneficial bacteria can be supplemented, harmful bacteria can be reduced, the influence of oral microorganisms such as porphyromonas gingivalis, treponema denticola, leptospira nigricans, enterobacter, streptococcus mutans, actinomyces viscosus and fusobacterium nucleatum on periodontal diseases such as gingivitis, dental plaque and the like can be avoided, and a certain prevention or treatment effect can be achieved. The third active ingredient used for the periodontal tissue inflammation and the periodontal tissue damage stage can include but is not limited to one or a combination of a plurality of plant extracts, glucosyl rutin, tetrapeptide-30, copper peptide, hyaluronic acid, nicotinamide, ascorbic acid, chitin and the like, so that the effects of resisting oxidation, regulating immunity, resisting inflammation, avoiding gingival bleeding, promoting wound healing and the like can be achieved, and the third active ingredient can play a positive role in preventing and treating periodontitis or periodontal tissue damage.
In conclusion, a more appropriate active substance composition can be selected according to different periodontal disease users and different periodontitis development stages so as to achieve more effective prevention and treatment effects. In addition, it is to be noted that the kinds of the sugar alcohol, the cationic bactericide and the plant extract in the present invention are not particularly limited, and may be selected by those skilled in the art according to actual needs, for example, the sugar alcohol may include but is not limited to at least one selected from sucralose, xylitol and sorbitol; cationic biocides may include, but are not limited to, chlorhexidine and/or benzalkonium chloride; the plant extract may include, but is not limited to, at least one selected from the group consisting of licorice extract, hypericum perforatum/leaf/stem extract, reed extract, poria cocos extract, fennel extract, hop extract, melissa extract, mistletoe leaf extract, and bunge auriculate root extract.
According to the embodiment of the invention, the freeze-dried preparation for oral care can further comprise 0.1-5 parts by weight of a hydrophobic modifier, for example, 0.5 part, 1 part, 2 parts, 3 parts or 4 parts, and the inventor finds that by adding the hydrophobic modifier into the formula of the freeze-dried preparation in the above addition amount, the probability of system collapse caused by easy water absorption can be remarkably reduced on the basis of maintaining the quick disintegration performance of the freeze-dried preparation, and the freeze-dried preparation can be ensured to keep certain mechanical strength and physical hardness before being dissolved in water. Illustratively, the amount of the hydrophobic modifier used in the preparation of the lyophilized preparation may be 0.1 to 5 parts by weight, based on 100 parts by weight of the lyophilized solution, and the specific amount may be adjusted within the above range under different humidity environments. In addition, it should be noted that the kind of the hydrophobic modifier in the present invention is not particularly limited, and may be selected by those skilled in the art according to actual needs, for example, the hydrophobic modifier may include, but is not limited to, one or a combination of several selected from triglycerides, fatty alcohol sulfate salts, fatty alcohol polyether sulfate salts, fatty acyl glutamate salts, alkyl glucosides, betaines, fatty acyl taurates, and fatty acyl methyl taurates.
According to the embodiment of the present invention, the lyophilized preparation for oral care may further include an auxiliary material, which may include but is not limited to at least one of a flavoring agent, a food coloring agent, and a moisture-proof agent, wherein the addition of the flavoring agent and/or the food coloring agent may further satisfy the use requirements of users for the taste and color of the lyophilized preparation, and the addition of the moisture-proof agent may further prevent the lyophilized preparation from collapsing due to excessive water absorption before dissolving in water. The kind and addition range of the seasoning, the food coloring matter and the moisture proofing agent in the present invention are not particularly limited, and those skilled in the art can select them according to actual needs, for example, the addition amount of the seasoning, the food coloring matter and the moisture proofing agent in the freeze-dried preparation may be 0.5 to 1 part by weight, the addition amount of the food coloring matter may be 0.05 to 0.15 part by weight, and the addition amount of the moisture proofing agent may be 0.1 to 0.5 part by weight. For another example, in the preparation of the lyophilized preparation, the seasoning may be added in an amount of 0.5 to 1, 1 or 0.8, etc. by weight, the food coloring may be added in an amount of 0.05 to 0.15, 0.1 or 0.05, etc. by weight, and the moisture-proofing agent may be added in an amount of 0.1 to 0.5, 0.2 or 0.3, etc. by weight, based on 100 parts by weight of the formulation of the lyophilized solution. Preferably, the total addition amount of the auxiliary materials in the lyophilized preparation may be not more than 2 parts by weight, more preferably, may not be more than 1 part by weight, whereby better safety may be secured.
According to an embodiment of the present invention, a lyophilized liquid required for preparing the lyophilized formulation may include 45 to 80 parts by weight of water or an aqueous solution based on the formulation of the above lyophilized formulation for oral care. For example, the amount of water or aqueous solution may be specifically 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, etc., which is more advantageous in that the prepared lyophilized preparation has sufficient microscopic pores, thereby further improving the instant dissolution effect of the lyophilized preparation. Further, the lyophilized liquid for preparing the lyophilized formulation may further include: the active ingredient of 4-8 weight portions, hydrophilic agent of 15-40 weight portions, binder of 2-7 weight portions and water of 45-80 weight portions, preferably, the treatment can be performed according to 100 weight portions. The inventor finds that by controlling the freeze-drying liquid to be the formula composition, the prepared freeze-drying preparation has good quick dissolving rate, mechanical strength and physical hardness, for example, the dissolution time of the freeze-drying preparation obtained by the formula composition in a water tank of a tooth flusher can be as low as 12-18 s, the flushing pressure of the tooth flusher during the dissolution process and after the dissolution can be maintained at a level equivalent to the flushing pressure of the freeze-drying preparation not added, for example, for the tooth flusher with the flushing pressure of 82-85 psi, after the freeze-drying preparation is dissolved, the flushing pressure can be maintained above 80psi, the freeze-drying preparation is not blocked in the water tank of the tooth flusher after the dissolution, the influence on the flushing pressure of the tooth flusher is small, the stability is basically maintained, and meanwhile, the acceptable drop height of the freeze-drying preparation is not less than 0.54, which indicates that the freeze-drying preparation has good mechanical strength and physical hardness.
According to the embodiment of the invention, the freeze-dried preparation for oral care can be realized by four steps of pretreatment, freeze drying, primary drying and secondary drying, wherein different freeze-dried liquid formulas can be designed according to different periods of periodontal diseases in the pretreatment stage, and the pressure range of a freeze dryer can be 0.2 MPa-1.0 MPa, so that the freeze-drying effect can be further ensured, the freeze-dried preparation with a proper micro-pore structure can be obtained, and the instant effect can be further ensured.
According to the embodiment of the present invention, the specific shape of the lyophilized preparation for oral care in the present invention is not particularly limited, and those skilled in the art can select it according to actual needs, for example, the lyophilized preparation may be preferably a pill or tablet, etc., such as a lyophilized ball or a lyophilized tablet, thereby more facilitating the storage and taking of the lyophilized preparation, wherein the size of the pill or tablet is not particularly limited, and those skilled in the art may select it according to actual needs, for example, the size of the pill or tablet in any direction may be not more than 20mm, thereby more facilitating the taking of the lyophilized preparation and the control of a single dose. Further, the mass of the lyophilized preparation is not particularly limited, and may be selected by those skilled in the art according to actual needs, for example, the lyophilized preparation may be preferably a block-shaped body with a mass of 0.2g to 2g, specifically 0.3g, 0.5g, 0.8g, 1g, 1.2g, 1.5g, or 1.8g, and the like, thereby facilitating the adjustment of the dosage for a single use.
In summary, the lyophilized formulation for oral care according to the above embodiment of the present invention has at least the following advantages:
1. the lyophilized formulation product of the present invention is safer than other types of oral tablet products for oral care for different periodontitis conditions. The ingredient table of the freeze-dried preparation product in the invention is relatively simple, the use of ingredients such as foaming agent, preservative and the like in the product can be reduced or directly omitted, and the safety risk avoidance is very important for patients with periodontal diseases in the process of using related products. Moreover, the ingredients used in the product have been subjected to long-term marketing tests, which can greatly reduce the safety risks for periodontal patients. Meanwhile, with the continuous popularization of the freeze-drying process, the cost of unit freeze-drying products is reduced year by year, the technical development can meet the household use standard more and more, meanwhile, the requirement of more people on periodontal care can be met in the future, and meanwhile, the loss of active ingredients can be reduced, so that the selection range of the freeze-drying preparation for the selectable active ingredients is widened.
2. The freeze-dried preparation can be edible and safe according to the selection of ingredients, and does not bring danger even if being swallowed.
3. The freeze-dried preparation has higher rehydration rate and is easier, which is more beneficial to the action of the active ingredient on periodontal sites, and can avoid the loss of the active ingredient caused by overlong retention time of the active ingredient in oral cavity, and the problem of water pipe blockage or scale deposition on the inner wall of a container can not exist when the active ingredient is dissolved in water.
4. Under the current stage daily care scene, the same oral care mode is unreasonably provided aiming at different periodontal disease onset stages, the general care mode can cause further deterioration of the disease condition of patients, the freeze-dried preparation can select the required composition of active ingredients aiming at different users and the development stages of periodontal disease to achieve the targeted prevention and treatment effect, therefore, different care modes are provided for consumers in different periodontal disease stages, new possibility can be provided for the periodontal care market in the future, and the improvement of the overall situation of the periodontal disease in China can be promoted.
5. The freeze-dried preparation can be matched with the use scenes of oral care products according to different periodontal disease onset stages. Taking a tooth flusher as an example, the tooth flusher has extremely high requirement on the solubility of a tablet product due to the hardware characteristics, and the freeze-dried preparation disclosed by the invention can realize the dissolution requirement of almost all use scenes of the tooth flusher due to the loose and porous characteristic of the freeze-dried preparation and can ensure that active matters in the freeze-dried preparation can be properly dissolved and dispersed in a water tank of the tooth flusher, so that the formed related solution can be directly applied to periodontal parts, and the rapid loss of the active matters caused by rapid metabolism of oral saliva can be prevented compared with other tablet products.
6. The application scene of the freeze-dried preparation is not particularly limited, the freeze-dried preparation can be applied to a tooth flusher to realize the functional synergy of oral cleaning and periodontal disease prevention and control, can also be used in other oral care products or devices such as mouthwash, and the like, or can also be directly mixed with water to be used as mouthwash.
According to yet another aspect of the invention, an oral care product is provided. According to an embodiment of the present invention, the oral care product comprises the above-described lyophilized formulation for oral care. Therefore, the characteristics and effects described for the above lyophilized preparation for oral care are also applicable to the oral care product, and are not described in detail herein. In general, the oral care product can realize the synergy of the self inherent function and the functions of preventing and treating the periodontal disease, and can also adapt freeze-dried preparations with different active ingredients according to the actual oral conditions of different periodontal disease users, thereby realizing the targeted care aiming at different stages of the periodontal disease development. It should be noted that the specific type of oral care product in the present invention is not particularly limited, and those skilled in the art can select the oral care product according to actual needs. For example, the oral care product may include, but is not limited to, a mouthrinse, a mouthwash or mouthrinse kit, and the like.
The inventor finds that the existing oral products are mainly divided into fast-selling products and dental appliances, the mainstream of the existing oral products still focuses on the cleaning and whitening functions of the toothbrush and the toothpaste on the surfaces of oral teeth, and the novel products for caring the periodontal disease of the gum are still not reasonably developed although the market development is vigorous. For example, the existing tooth irrigator can effectively clean food residues at the position of a tooth gap to realize the function of preventing bacterial proliferation by acting on the periodontal position, and can prevent gingivitis to a certain extent. However, this function is still not well developed in the public's daily prevention and treatment of periodontal disease, and the tooth irrigator, if it is used only for cleaning, does not play a relevant role for most periodontitis users. In fact, the tooth flusher can be used as an excellent carrier to directly deliver ingredients for treating and preventing periodontal diseases to the deep part of the tooth space and even the periodontal disease, and the tooth flusher products developed for the function on the market are usually realized by dissolving tablet bactericide in a water tank, however, the method has great limitation, once the dissolution rate of the dissolution tablet is not enough, the difficult-to-dissolve particle substances are easy to cause blockage at a water outlet to affect the water pressure of the tooth flusher, and related substances attached to the wall of the water tank can also cause dirt to be difficult to clean.
In view of this, according to yet another aspect of the present invention, the present invention provides a dental irrigator. According to an embodiment of the present invention, as understood with reference to fig. 1, the dental irrigator comprises: the device comprises a host 1, a water tank 2 and a nozzle 6, wherein a liquid pumping assembly is arranged in the host 1, and a water inlet 5 is formed in the liquid pumping assembly; the water tank 2 is used for containing liquid, and the water tank 2 is communicated with the liquid pumping assembly; the nozzle 6 is connected with the main machine 1 and is communicated with the liquid pumping assembly, and when the liquid pumping assembly works, liquid in the water tank 2 is pumped to the nozzle 6 and is sprayed out from the nozzle 6; wherein at least one of the main body 1 or the water tank 2 is provided with a feed port 3 (as understood with reference to fig. 1, the water tank is provided with the feed port 3), the feed port 3 is used for adding a lyophilized preparation into the water tank 2, the lyophilized preparation can be dissolved in the liquid in the water tank 2, and the lyophilized preparation comprises the above-mentioned lyophilized preparation for oral care. Compared with the prior art, the tooth flusher can be matched with the freeze-dried preparation for use, wherein the freeze-dried preparation has the remarkable advantage of high rehydration and dissolution speed, can be matched with the tooth flusher for use and can be quickly dissolved in water, the tooth flusher cannot be blocked, dirt which is difficult to clean cannot be formed on the inner wall of a water tank, and active ingredients for treating and preventing periodontal diseases can be directly delivered to the deep part of a tooth gap or even a periodontal disease along with water flow.
According to an embodiment of the present invention, as shown in fig. 1, a closable feed opening 3 may be provided on a water tank 2, and the feed opening 3 may be sealed and opened by a sealing cover 7 provided in cooperation therewith, so that, when it is required to deliver active ingredients of a lyophilized preparation to periodontal pockets using a tooth irrigator as a carrier, the sealing cover 7 may be opened and the lyophilized preparation may be added into the water tank through the feed opening 3, and then the feed opening 3 may be closed by the sealing cover 7, so that it is possible to select whether to add or not to add the lyophilized preparation, when to add the lyophilized preparation, and what kind of active ingredients to add the lyophilized preparation according to actual use requirements, thereby more easily satisfying the use requirements of different users. Furthermore, the size of the feeding port 3 in the tooth flushing device is not particularly limited, and those skilled in the art can reasonably select the size according to the type and size of different freeze-dried preparations, for example, the size of the feeding port 3 in the tooth flushing device can be not less than 10mm, such as 10mm, 12mm, 15mm, 18mm, 20mm, 25mm, etc., so that the freeze-dried preparations can be smoothly added without affecting the overall structure of the water tank of the tooth flushing device; further, the minimum size of the opening of the feed port 3 can be made not less than 10mm, thereby facilitating smooth addition of the lyophilized preparation of pellets or tablets. The shape of the feeding port 3 in the tooth punching device is not particularly limited, and may be selected by those skilled in the art according to actual needs, and may be, for example, circular, square, or oval.
According to the embodiment of the present invention, the position of the feeding port 3 on the water tank 2 is not particularly limited, and may be selected by those skilled in the art according to actual needs, and preferably, the feeding port 3 may be disposed at the lower portion of the water tank 2, and more preferably, at the bottom of the water tank 2, wherein by disposing the feeding port at the lower portion or the bottom of the water tank, the lyophilized preparation can be better contacted with moisture during floating, so that the dissolution rate of the lyophilized preparation can be sufficiently increased and the dissolution is more uniform, thereby further improving the instant dissolution effect of the lyophilized preparation and avoiding the problems of water tank blockage or inner wall scale.
According to the embodiment of the invention, the water tank can be detachably arranged, so that the water tank is convenient to mount and dismount, and the main machine of the tooth flushing device or the water tank can be conveniently cleaned, maintained or replaced independently.
According to the embodiment of the invention, the tooth flusher further comprises a pump liquid pipe 4 for communicating the water tank 2 with the pump liquid assembly, wherein the water inlet 5 can be arranged at the lower part of the auxiliary agent 1, the pump liquid pipe 4 is connected with the water inlet 5 and is arranged in the water tank 2 for sucking water in the water tank 2 into the main machine 1 and pumping the water out of the nozzle 6, preferably, the pump liquid pipe 4 can also be provided with a filter screen (not shown), and particularly can be arranged at the end close to the water inlet 5 or the end for being arranged in the water tank 2, thereby further preventing large particles or floccules and the like possibly existing in the water tank from directly entering the pump liquid assembly to cause nozzle blockage or damage of the main machine, and ensuring the normal use of the tooth flusher.
It should be noted that, the overall structure and the working principle of the tooth irrigator in the prior art are also applicable to the tooth irrigator in the present invention, and are not described herein again.
The following describes embodiments of the present invention in detail. The following examples are illustrative only and are not to be construed as limiting the invention. The examples, where specific techniques or conditions are not indicated, are to be construed according to the techniques or conditions described in the literature in the art or according to the product specifications. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
Example 1
A freeze-dried tablet for repairing damaged dentin. The formulation of the lyophilized liquid of the lyophilized tablet is shown in table 1.
TABLE 1 formulation of lyophilized liquid for dentin damage repair
| Raw materials | Function of | Content (wt%) | |
| Sucrose | Hydrophilic agent | 15 | |
| PEG-400 | Hydrophilic agent | 3 | |
| Methyl cellulose | Binder | 1 | |
| Xanthan gum | Binder | 1 | |
| | Hydrophilic agent | 2 | |
| Sodium fluoride | |
2 | |
| Hydroxyapatite | Active ingredient | 5 | |
| Sucralose | Active ingredient | 1 | |
| Edible pigment | Color matching | 0.1 | |
| Water (W) | Solvent(s) | 69.9 |
Comparative example 1
Dissolving and tabletting aiming at repairing damaged dentin. The formulation of the compressed tablets is shown in table 2.
TABLE 2 dentin damage repair dissolution tableting formula
Example 2
A lyophilized tablet for inhibiting dental plaque. The formulation of the lyophilized liquid of the lyophilized tablet is shown in Table 3.
TABLE 3 Freeze-dried liquid formulation of freeze-dried tablets for plaque inhibition
| Raw materials | Function of | Content (wt%) | |
| Mannitol | Hydrophilic agent | 10 | |
| Polyethylene glycol | Hydrophilic agent | 3 | |
| Methyl cellulose | Binder | 1 | |
| Xanthan gum | Binder | 1 | |
| | Hydrophilic agent | 2 | |
| Chlorhexidine | Active ingredient | 1 | |
| Cationic antibacterial peptide | Active ingredient | 1 | |
| Xylitol, its preparation method and use | |
2 | |
| Edible pigment | Color matching | 0.1 | |
| Water (W) | Solvent(s) | 78.9 |
Comparative example 2
Effervescent tablets for plaque inhibition. The effervescent tablet formulation is shown in table 4.
Table 4 effervescent tablet formulation for plaque inhibition
Example 3
A freeze-dried tablet for periodontal tissue repair. The formulation of the lyophilized liquid of the lyophilized tablet is shown in Table 5.
TABLE 5 Freeze-drying liquid formulation of freeze-dried tablets for periodontal tissue repair
| Raw materials | Function of | Content (wt%) |
| Maltodextrin | Hydrophilic agent | 15 |
| Mannitol | Hydrophilic agent | 18 |
| Methyl cellulose | Binder | 4 |
| Polyethylene glycol | |
6 |
| Xanthan gum | Binder | 3 |
| Glycyrrhiza extract | Active ingredient | 3 |
| Radix Cynanchi auriculati extract | Active ingredient | 1 |
| Ascorbic acid | |
2 |
| Sucralose | Active ingredient | 1 |
| Edible essence | Color matching | 0.1 |
| Triglyceride | Moisture-proof article | 0.2 |
| Water (W) | Solvent(s) | 46.7 |
Comparative example 3
A freeze-dried tablet for periodontal tissue repair. The formulation of the lyophilized liquid of the lyophilized tablet is shown in Table 6.
TABLE 6 Freeze-drying liquid formulation of freeze-dried tablets for periodontal tissue repair
Evaluation of the effects:
comparing the dissolution efficiency of the disintegrating tablets prepared in examples 1-3 and comparative examples 1-3 in a water tank of a tooth flusher, the water pressure of the tooth flusher and drop tests at different heights, wherein the test results are shown in table 7 under the same conditions, wherein the dissolution efficiency of the tooth flusher in the same model and specification is tested in example 1 and comparative example 1, and the flushing pressure of the tooth flusher in pure water is 88 psi; in example 2 and comparative example 2, the dissolution efficiency and the water pressure of the tooth flusher were tested by using the same type and specification of tooth flushers, and the flushing pressure of the tooth flusher under pure water was 85 psi; example 3 and comparative example 3 dissolution efficiency and water pressure of the dental irrigator were measured using the same model of dental irrigator, and the irrigation pressure of the dental irrigator under pure water was 93 psi.
TABLE 7 comparison of test results of disintegrating tablets prepared in examples 1 to 3 and comparative examples 1 to 3
| Dissolution time in water tank | Pressure of tooth rinsing device | Height of acceptable fall | |
| Example 1 | 12S | 86psi | 0.54m |
| Comparative example 1 | 70S | 72psi | 0.69m |
| Example 2 | 18S | 82psi | 0.58m |
| Comparative example 2 | 67S | 43psi | 1.7m |
| Example 3 | 14S | 91psi | 0.65m |
| Comparative example 3 | 17S | 89psi | 0.21m |
Results and conclusions: as can be seen from Table 7, the freeze-dried tablet prepared by the formulation of the above embodiment of the present invention has a shorter dissolution time in the water tank of the tooth rinsing device, which can be as low as 12-18 s, and the rinsing pressure of the tooth rinsing device after dissolution is equivalent to that of the rinsing pressure under the condition of pure water, which means that the use of the tooth rinsing device is not affected after dissolution of the freeze-dried tablet, the water tank of the tooth rinsing device is not blocked, and meanwhile, the acceptable drop height ratio of the freeze-dried tablet is not less than 0.54m, and the freeze-dried tablet has better mechanical strength and better dissolution efficiency.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.
Claims (20)
1. A lyophilized formulation for oral care comprising: the composition comprises 3-10 parts by weight of active ingredients, 10-60 parts by weight of hydrophilic agents and 1-30 parts by weight of binding agents, wherein the active ingredients comprise at least one of a first active ingredient, a second active ingredient and a third active ingredient, the first active ingredient is an active substance for preventing and/or treating dentin damage, the second active ingredient is an active substance for preventing and/or treating dental plaque generation, and the third active ingredient is an active substance for preventing and/or treating periodontal tissue inflammation and/or dental tissue damage.
2. The lyophilized formulation according to claim 1, wherein the hydrophilic agent comprises at least one selected from mannitol, sucrose, maltodextrin, polyethylene glycol and polypropylene glycol.
3. The lyophilized formulation of claim 1, wherein the binder comprises at least one selected from the group consisting of hydroxyethyl starch, sodium alginate, methylcellulose, gelatin, gum arabic, xanthan gum, gellan gum, sclerotium rolfsii gum, pullulan and carob gum.
4. The lyophilized formulation according to claim 1, wherein the first active ingredient comprises at least one selected from the group consisting of hydroxyapatite, sodium fluoride, calcium lactate, milk extract and sugar alcohol.
5. The lyophilized formulation according to claim 4, wherein the sugar alcohol comprises at least one selected from the group consisting of sucralose, xylitol, and sorbitol.
6. The lyophilized formulation according to claim 1, wherein the second active ingredient comprises at least one selected from the group consisting of a probiotic, an antimicrobial peptide, an immunoglobulin, and a cationic bactericide.
7. The lyophilized formulation according to claim 6, wherein the cationic bactericide comprises chlorhexidine and/or cetylpyridinium chloride.
8. The lyophilized formulation according to claim 1, wherein the third active ingredient comprises at least one selected from the group consisting of plant extract, glucosylrutin, tetrapeptide-30, copper peptide, hyaluronic acid, nicotinamide, ascorbic acid and chitin.
9. The lyophilized formulation of claim 8, wherein the botanical extract comprises at least one selected from the group consisting of licorice extract, hypericum perforatum/leaf/stem extract, reed extract, poria extract, fennel extract, hop extract, melissa extract, mistletoe leaf extract, and bunge auriculate root extract.
10. The lyophilized formulation according to claim 1, further comprising 0.1 to 5 parts by weight of a hydrophobic modifier.
11. The lyophilized formulation according to claim 10, wherein the hydrophobic modifier comprises at least one selected from the group consisting of triglycerides, fatty alcohol sulfate salts, fatty alcohol polyether sulfate salts, fatty acyl glutamates, alkyl glucosides, betaines, fatty acyl taurates, and fatty acyl methyl taurates.
12. The lyophilized formulation according to claim 1, further comprising not more than 2 parts by weight of an auxiliary material including at least one selected from the group consisting of a flavoring agent, a food coloring agent and a moisture-proof agent.
13. The lyophilized formulation according to any one of claims 1 to 12, wherein preparing the lyophilized liquid of the lyophilized formulation comprises: 45-80 parts by weight of water or an aqueous solution.
14. The lyophilized formulation of claim 13, wherein the lyophilization liquid comprises: 4-8 parts by weight of the active ingredient, 15-40 parts by weight of the hydrophilic agent, 2-7 parts by weight of the binder and 45-80 parts by weight of water.
15. The lyophilized formulation according to claim 1 or 14, wherein the lyophilization pressure of the lyophilized formulation is 0.2MPa to 1.0 MPa.
16. The lyophilized formulation according to any one of claims 1 to 12, wherein the lyophilized formulation is a block-shaped body having a mass of 0.2g to 2.0g, and/or the lyophilized formulation is a pill or tablet having a size of not more than 20mm in any direction.
17. An oral care product comprising the lyophilized formulation of any one of claims 1 to 16.
18. A dental irrigator, comprising:
the main machine is internally provided with a liquid pumping assembly;
the water tank is used for containing liquid and is communicated with the liquid pumping assembly; and the number of the first and second groups,
the nozzle is connected with the host and communicated with the liquid pumping assembly, and when the liquid pumping assembly works, liquid in the water tank is pumped to the nozzle and sprayed out of the nozzle;
wherein at least one of the host or the water tank is provided with a filling port for adding a lyophilized formulation to the water tank, the lyophilized formulation being soluble in a liquid in the water tank, the lyophilized formulation comprising the lyophilized formulation for oral care of any one of claims 1-16.
19. The dental irrigator of claim 18 wherein the filling port is located on the water tank and the minimum dimension of the opening of the filling port is no less than 10 mm.
20. The dental irrigator of claim 18 further comprising a pump tube communicating the water tank with the pump assembly, the pump tube having a filter screen thereon.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2012101332A (en) * | 2012-01-13 | 2013-07-20 | Владимир Николаевич Иванов | DENTAL PASTE CONTAINING LYOPHILIZED MASS OF LIVING BIFIDOBACTERIA |
| CN106859794A (en) * | 2017-03-24 | 2017-06-20 | 江苏鹿得医疗电子股份有限公司 | A kind of portable tooth flusher |
| CN107920986A (en) * | 2015-07-17 | 2018-04-17 | Ab生物有限公司 | Self-contained film composition for oral care |
| CN110755298A (en) * | 2019-11-15 | 2020-02-07 | 重庆登康口腔护理用品股份有限公司 | Freeze-dried oral care composition and application thereof |
| CN212346772U (en) * | 2020-03-03 | 2021-01-15 | 深圳瑞圣特电子科技有限公司 | Water tank of tooth flushing device and tooth flushing device |
-
2021
- 2021-12-31 CN CN202111669826.3A patent/CN114392238A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2012101332A (en) * | 2012-01-13 | 2013-07-20 | Владимир Николаевич Иванов | DENTAL PASTE CONTAINING LYOPHILIZED MASS OF LIVING BIFIDOBACTERIA |
| CN107920986A (en) * | 2015-07-17 | 2018-04-17 | Ab生物有限公司 | Self-contained film composition for oral care |
| CN106859794A (en) * | 2017-03-24 | 2017-06-20 | 江苏鹿得医疗电子股份有限公司 | A kind of portable tooth flusher |
| CN110755298A (en) * | 2019-11-15 | 2020-02-07 | 重庆登康口腔护理用品股份有限公司 | Freeze-dried oral care composition and application thereof |
| CN212346772U (en) * | 2020-03-03 | 2021-01-15 | 深圳瑞圣特电子科技有限公司 | Water tank of tooth flushing device and tooth flushing device |
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