CN114344189A - Sialic acid-containing water-in-oil type skin cream and preparation method thereof - Google Patents
Sialic acid-containing water-in-oil type skin cream and preparation method thereof Download PDFInfo
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Abstract
The invention provides sialic acid-containing water-in-oil skin cream and a preparation method thereof. The sialic acid-containing water-in-oil type skin cream comprises the following raw materials in percentage by weight: 0.1-2% of sialic acid, 0.1-1% of bisabolol, 0.1-1% of vitamin E, 3-10% of emulsifier, 20-35% of grease, 3-10% of sun-screening agent, 10-20% of glycerol, 1-10.5% of auxiliary material and the balance of deionized water. The sialic acid in the sialic acid-containing water-in-oil type skin cream has higher retention rate, shows excellent physical stability in a high-temperature acceleration test and a long-term test, obviously improves the quality of cosmetics, integrates sun protection, isolation, moisture retention and aging resistance, and has the advantages of mild property, small irritation, high moisture degree, easiness in absorption, safety, no toxic or side effect and the like.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to sialic acid-containing water-in-oil skin cream and a preparation method thereof.
Background
The water-in-oil (W/O) system is one of the most commonly used emulsification systems for topical cream emulsions, and is an emulsification system in which water is dispersed in oil, the water being the internal phase and the oil being the continuous external phase. It is known that the stability of W/O systems is greatly changed by temperature, and the high content of grease in the external phase of W/O systems causes sticky and heavy skin feel and is not light and cool enough, but the W/O systems are beneficial to water locking, moisture retention and external damage resistance, and the properties make the W/O systems more applied in sunscreen products, but physical and/or chemical sunscreens in the sunscreen products can have potential allergy to human skin.
Sialic acid (Sialic acid) is an acidic amino sugar containing 9 carbon atoms and having a pyranose structure, also known as N-acetylneuraminic acid, cubilose acid and cubilose element, widely exists in various biological tissues, is an important part forming a cell surface complex carbohydrate, and has physiological effects of promoting brain development, improving memory, resisting inflammation, viruses and tumors, improving the absorption of vitamins and minerals by intestinal tracts and the like. With the intensive research and understanding of sialic acid, sialic acid also inhibits the oxidation of tyrosine, reduces melanin deposition and thus improves the appearance of skin. Therefore, sialic acid can be widely used in the cosmetic field.
However, the applicant found that the sialic acid is subjected to gravity stratification when applied to a water-in-oil system, and further found that if the system is unstable, the sialic acid is subjected to degradation reaction in a W/O system, so that the sialic acid content in the system is reduced, and meanwhile, the generated by-products cause discoloration of the system, so that the quality of the cosmetic product is seriously reduced.
In view of this, the invention is particularly proposed.
Disclosure of Invention
The object of the present invention is to solve at least to some extent one of the above mentioned technical problems. The invention aims to provide the sialic acid-containing water-in-oil type skin cream and the preparation method thereof, the water-in-oil type skin cream has excellent physical and chemical stability, remarkably improves the quality of cosmetics, has good anti-inflammation and anti-allergy effects, and is particularly suitable for people with sensitive skin. The invention also provides a preparation method of the sialic acid-containing water-in-oil type skin cream.
In order to achieve the above object, the first aspect of the present invention provides a sialic acid-containing water-in-oil skin cream, which comprises the following raw materials by weight: 0.1-2% of sialic acid, 0.1-1% of bisabolol, 0.1-1% of vitamin E, 3-10% of emulsifier, 20-35% of grease, 3-10% of sun-screening agent, 10-20% of glycerol, 1-10.5% of auxiliary material and the balance of deionized water.
The sialic acid comprises free sialic acid monomer or sialic acid salt, the sialic acid salt is metal salt, and the common sialic acid salt comprises sodium sialic acid, potassium sialic acid, magnesium sialic acid and the like.
Further, the emulsifier comprises the following components in weight ratio (1-4): (1-3): (1-3) cetyl polyethylene glycol/polypropylene glycol-10/1 dimethicone, lauryl alcohol PEG-9 dimethiconoethyl dimethicone, and sorbitan sesquioleate. Wherein cetyl polyethylene glycol/polypropylene glycol-10/1 dimethyl siloxane is liquid nonionic emulsifier.
Further, the grease comprises one or two of isomeric hexadecane and polydimethylsiloxane.
Further, the grease comprises the following components in percentage by weight (1-1.5): the isomeric hexadecanes and polydimethylsiloxanes of (1-2).
Further, the sunscreen agent comprises one or more of magnesium stearate, zinc oxide, methylene bis-benzotriazole tetramethyl butyl phenol and oleophylic titanium dioxide.
Further, the sunscreen agent comprises the following components in a weight ratio of (0.5-4): (1-2): (0.5-2): (1-2) magnesium stearate, zinc oxide, methylene bis-benzotriazole tetramethylbutylphenol, and oleophilic titanium dioxide.
Furthermore, the auxiliary materials comprise 0.15-1.5% of thickening agent, 0.05-3% of neutralizing agent, 0.1-0.5% of metal complexing agent, 0.5-3% of metal salt stabilizer and 0.2-1% of preservative.
Further, the thickening agent is prepared from the following components in a weight ratio (0.1-1): xanthan gum and acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer (0.05-0.5);
and/or the neutralizing agent is triethanolamine;
and/or the metal complexing agent is EDTA-2 Na;
and/or the metal salt stabilizer is magnesium sulfate;
and/or, the preservative IS selected from Germall IS-45 and/or methylparaben.
Further, the water-in-oil type skin cream comprises the following raw materials in percentage by weight: 0.1-2% of sialic acid, 0.1-1% of bisabolol, 0.1-1% of vitamin E, 1-4% of cetyl polyethylene glycol/polypropylene glycol-10/1 dimethyl siloxane, 1-3% of lauryl alcohol PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 1-3% of sorbitan sesquioleate, 10-15% of isomeric hexadecane, 10-20% of polydimethylsiloxane, 0.5-4% of magnesium stearate, 1-2% of zinc oxide, 0.5-2% of methylene bis-benzotriazole tetramethylbutylphenol, 1-2% of lipophilic titanium dioxide, 10-20% of glycerol, 0.1-1% of xanthan gum, 0.05-0.5% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.05-3% of triethanolamine, 0.1-0.5% of EDTA-2Na, 0.5-3% of magnesium sulfate, 450.1-0.5% of Germall IS-450, 0.1-0.5% of methyl hydroxybenzoate and the balance of deionized water.
The second aspect of the present invention provides a preparation method of the above sialic acid containing water-in-oil type skin cream, comprising the following steps:
(1) weighing the raw materials according to the weight percentage for later use;
(2) putting deionized water, sialic acid, glycerol, a metal complexing agent, a metal salt stabilizer and a thickening agent into a stirring pot, heating to 75-85 ℃ while stirring to fully dissolve the sialic acid, and preserving heat for 5-15 minutes to obtain a phase A;
(3) mixing magnesium stearate, zinc oxide, oleophylic titanium dioxide and grease uniformly, grinding for 3 times by using a three-roll grinder, and obtaining a B phase after confirming that the mixture is uniform and has no particles;
(4) adding emulsifier, bisabolol, vitamin E, and methylene bis-benzotriazole tetramethyl butyl phenol into another stirring pot, heating to 75-85 deg.C while stirring, dissolving completely, and keeping the temperature for 5-15 min to obtain phase C;
(5) preheating an emulsifying pot to 75-80 ℃, vacuumizing to-0.03 MPa, pumping the phase A, the phase B and the phase C into the emulsifying pot, and homogenizing and emulsifying for 5-15 minutes;
(6) cooling to 46 deg.C at a rate of 1 deg.C per minute, adding neutralizer and antiseptic, and stirring;
(7) cooling to 36 deg.C at a rate of 1 deg.C per minute, vacuumizing, and discharging.
The invention has the following advantages:
the sialic acid in the sialic acid-containing water-in-oil type skin cream has higher retention rate, shows excellent physical stability in a high-temperature acceleration test and a long-term test, obviously improves the quality of cosmetics, integrates sun protection, isolation, moisture retention and aging resistance, and has the advantages of mild property, small irritation, high moisture degree, easiness in absorption, safety, no toxic or side effect and the like.
The active ingredients of the invention, sialic acid and bisabolol, play a synergistic role, have good anti-inflammatory and anti-allergy effects, and can effectively relieve the irritation of physical sunscreen agents and chemical sunscreen agents in the existing sunscreen products to the skin.
The method has the advantages of simple process, easy control and strong operability, and is suitable for industrial production.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or instruments used are conventional products available from regular distributors, not indicated by the manufacturer.
In the following examples and comparative examples, "%" means weight percent, unless otherwise specified.
Example 1
The embodiment provides a sialic acid-containing water-in-oil skin cream, which comprises the following raw materials: 0.5% of sialic acid, 0.1% of bisabolol, 0.2% of vitamin E, 4% of cetyl polyethylene glycol/polypropylene glycol-10/1 dimethyl siloxane, 2% of lauryl alcohol PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 1.5% of sorbitan sesquioleate, 10% of isocetyl alkane, 15% of polydimethylsiloxane, 0.8% of magnesium stearate, 1% of zinc oxide, 1% of methylene bis-benzotriazole tetramethylbutylphenol, 2% of lipophilic titanium dioxide, 10% of glycerol, 0.4% of xanthan gum, 0.3% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 1.2% of triethanolamine, 0.2% of EDTA-2 Na0%, 1% of magnesium sulfate, 450.3% of Germall IS-450.3%, 0.2% of hydroxybenzyl ester and the balance of deionized water.
The preparation method of the water-in-oil type skin cream comprises the following steps:
(1) weighing the raw materials according to the weight percentage for later use;
(2) putting deionized water, sialic acid, glycerol, EDTA-2Na, magnesium sulfate, xanthan gum and acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer into a stirring pot, heating to 80 ℃ while stirring to fully dissolve the polymer, and preserving heat for 10 minutes to obtain a phase A;
(3) mixing magnesium stearate, zinc oxide, oleophylic titanium dioxide, isomeric hexadecane and polydimethylsiloxane uniformly, grinding for 3 times by using a three-roll grinder, and obtaining a B phase after confirming that no particles exist uniformly;
(4) placing cetyl polyethylene glycol/polypropylene glycol-10/1 dimethyl siloxane, lauryl alcohol PEG-9 dimethyl silica ethyl dimethyl polysiloxane, sorbitan sesquioleate, bisabolol, vitamin E and methylene bis-benzotriazole tetramethyl butyl phenol into another stirring pot, heating to 80 ℃ while stirring to fully dissolve, and keeping the temperature for 10 minutes to obtain a phase C;
(5) preheating an emulsifying pot to 80 ℃, vacuumizing to-0.03 MPa, pumping the phase A, the phase B and the phase C into the emulsifying pot, and homogenizing and emulsifying for 10 minutes;
(6) cooling to 46 deg.C at a rate of 1 deg.C per minute, and adding triethanolamine, Germall IS-45, and methyl hydroxybenzoate;
(7) cooling to 36 deg.C at a rate of 1 deg.C per minute, vacuumizing, and discharging;
(8) and (4) performing sampling inspection on the finished product after filling and packaging, and warehousing after the finished product is qualified.
Example 2
The embodiment provides a sialic acid-containing water-in-oil skin cream, which comprises the following raw materials: 0.1% of sialic acid, 0.5% of bisabolol, 0.8% of vitamin E, 2.5% of cetyl polyethylene glycol/polypropylene glycol-10/1 dimethyl siloxane, 2% of lauryl alcohol PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 1% of sorbitan sesquioleate, 10% of isocetyl alkane, 10% of polydimethylsiloxane, 1% of magnesium stearate, 2% of zinc oxide, 0.5% of methylene bis-benzotriazole tetramethylbutylphenol, 1% of lipophilic titanium dioxide, 15% of glycerol, 0.5% of xanthan gum, 0.2% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 1.6% of triethanolamine, 0.2% of EDTA-2Na, 1.5% of magnesium sulfate, Germall IS-450.3%, 0.1-0.2% of hydroxybenzyl ester and the balance of deionized water.
The preparation method of the water-in-oil skin cream of this example is the same as that of example 1.
Example 3
The embodiment provides a sialic acid-containing water-in-oil skin cream, which comprises the following raw materials: 0.5% of sialic acid, 0.5% of bisabolol, 0.6% of vitamin E, 2.5% of cetyl polyethylene glycol/polypropylene glycol-10/1 dimethyl siloxane, 3% of lauryl alcohol PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 3% of sorbitan sesquioleate, 15% of isocetyl alkane, 20% of polydimethylsiloxane, 2% of magnesium stearate, 1% of zinc oxide, 0.8% of methylene bis-benzotriazole tetramethylbutylphenol, 2% of lipophilic titanium dioxide, 12% of glycerol, 0.6% of xanthan gum, 0.2% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 1.8% of triethanolamine, 0.25% of EDTA-2Na, 1.2% of magnesium sulfate, 1.3% of Germall IS-450.3%, 0.2% of hydroxybenzyl ester and the balance of deionized water.
The preparation method of the water-in-oil skin cream of this example is the same as that of example 1.
Example 4
The embodiment provides a sialic acid-containing water-in-oil skin cream, which comprises the following raw materials: 0.2% of sialic acid, 0.5% of bisabolol, 0.6% of vitamin E, 4% of cetyl polyethylene glycol/polypropylene glycol-10/1 dimethyl siloxane, 2% of lauryl alcohol PEG-9 polydimethylsiloxane, 1% of sorbitan sesquioleate, 12% of isocetyl alkane, 15% of polydimethylsiloxane, 2% of magnesium stearate, 2% of zinc oxide, 0.5% of methylene bis-benzotriazole tetramethyl butyl phenol, 1% of oleophilic titanium dioxide, 10% of glycerol, 0.6% of xanthan gum, 0.3% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 1.5% of triethanolamine, 0.2% of EDTA-2Na0, 1.5% of magnesium sulfate, Germall IS-450.3%, 0.2% of hydroxybenzyl ester and the balance of deionized water.
The preparation method of the water-in-oil skin cream of this example is the same as that of example 1.
Example 5
The embodiment provides a sialic acid-containing water-in-oil skin cream, which comprises the following raw materials: 1% of sialic acid, 0.1% of bisabolol, 0.6% of vitamin E, 1% of cetyl polyethylene glycol/polypropylene glycol-10/1 dimethyl siloxane, 2% of lauryl alcohol PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 2% of sorbitan sesquioleate, 15% of isocetyl alkane, 12% of polydimethylsiloxane, 1% of magnesium stearate, 1.5% of zinc oxide, 1.2% of methylene bis-benzotriazole tetramethylbutylphenol, 2% of oleophilic titanium dioxide, 15% of glycerol, 0.6% of xanthan gum, 0.1% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 1.5% of triethanolamine, 0.3% of EDTA-2Na0, 1.2% of magnesium sulfate, Germall IS-450.2% and the balance of deionized water.
The preparation method of the water-in-oil skin cream of this example is the same as that of example 1.
Example 6
The embodiment provides a sialic acid-containing water-in-oil skin cream, which comprises the following raw materials: 0.5% of sodium saliva, 0.1% of bisabolol, 0.2% of vitamin E, 4% of cetyl polyethylene glycol/polypropylene glycol-10/1 dimethyl siloxane, 2% of lauryl alcohol PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 1.5% of sorbitan sesquioleate, 10% of isocetyl alkane, 15% of polydimethylsiloxane, 0.8% of magnesium stearate, 1% of zinc oxide, 1% of methylene bis-benzotriazole tetramethylbutylphenol, 2% of lipophilic titanium dioxide, 10% of glycerol, 0.4% of xanthan gum, 0.3% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 1.2% of triethanolamine, 0.2% of EDTA-2Na, 1% of magnesium sulfate, 450.3% of Germall IS-450, 0.2% of hydroxybenzyl ester and the balance of deionized water.
The preparation method of the water-in-oil skin cream of this example is the same as that of example 1.
Comparative example 1
The raw material components of the skin cream of this comparative example were the same as in example 1 except that: emulsifier in this comparative example: cetyl polyethylene glycol/polypropylene glycol-10/1 dimethicone 6%, sorbitan sesquioleate 1.5%.
The comparative example was prepared as in example 1.
Comparative example 2
The raw material components of the skin cream of this comparative example were the same as in example 1 except that: emulsifier in this comparative example: 4% of sorbitan monolaurate, 2% of lauryl alcohol PEG-9 polydimethylsiloxyethyl polydimethylsiloxane and 1.5% of sorbitan sesquioleate.
The comparative example was prepared as in example 1.
Comparative example 3
The raw material components of the skin cream of this comparative example were the same as in example 1 except that: emulsifier in this comparative example: 5% of cinnamyl alcohol PEG-9 polydimethylsiloxyethyl polydimethylsiloxane and 4% of sorbitan sesquioleate.
Comparative example 4
The raw material components of the skin cream of this comparative example were the same as in example 6 except that: emulsifier in this comparative example: cetyl polyethylene/polypropylene glycol-10/1 dimethicone 4%, polyoxyethylene (16) pentaerythritol mono-tall oil ester 2%, sorbitan sesquioleate 1.5%.
Test example 1
The water-in-oil type skin cream of the present invention was tested for high temperature stability and long term stability.
High-temperature stability: the skin creams of examples 1 to 6 and comparative examples 1 to 4 were placed in suitable containers, respectively, in a drying oven at a constant temperature of 50 ℃ for 10 days, and samples were taken at 0 th, 5 th and 10 th days, respectively, to examine the properties of the skin cream and the sialic acid content.
Long-term stability: the skin creams of examples 1-6 and comparative examples 1-4 were placed in suitable containers, respectively, in a constant temperature drying oven at (28 + -2) ° c for 12 months, and samples were taken at the end of 0, 3, 6, 9, and 12 months, respectively, to examine the properties of the skin cream and the sialic acid content.
Wherein, the sialic acid content is detected by High Performance Liquid Chromatography (HPLC), and the detection method comprises the following steps:
detection conditions are as follows: shimadzu Lc-15 c; detection Column Bio-Rad AMINEX HPX87Horganic Analysis Column (300X 7.8 mm); the column temperature is 60 ℃; the mobile phase is 6mmol sulfuric acid, and the flow rate is 0.6 ml/min; the detection wavelength is 210 nm.
The retention of sialic acid was calculated as follows:
retention ratio (%) ═ mt/m0×100％
Wherein m is0Initial testing of samples for sialic acid quality, mtThe quality of sialic acid was tested after a certain time for high temperature/long term experiments.
The test results for high temperature stability and long term stability are shown in table 1.
TABLE 1
The results show that: sialic acid in the water-in-oil type skin cream has higher retention rate, and simultaneously shows excellent physical stability in a high-temperature acceleration test and a long-term test.
Test example 2
The water-in-oil type skin cream of the present invention was subjected to hygienic microbiological examination and hygienic chemical examination.
The results show that: bacteria, mould and microzyme, coliform bacteria, staphylococcus aureus, pyocyanea, lead, mercury and arsenic are not detected in the water-in-oil type skin cream, and the water-in-oil type skin cream meets the regulation of technical standards for cosmetic safety.
Test example 3
The sensitization of the water-in-oil type skin cream of the present invention was evaluated.
Randomly selecting 20 healthy subjects between 18-45 years of age, excluding pregnant and lying-in women, randomly grouping into two groups, each group containing 10 subjects.
The subjects in experiment 1 group were applied daily with the skin cream prepared in example 1.
The subjects of the experimental 2 group were daily smeared with a blank matrix based on example 1 but without the addition of sialic acid and bisabolol.
According to the repetitive open type application test, the test substance is uniformly applied to the test site about 0.050(mL) times per day 2 times per day for 7 consecutive days, and skin reactions are observed, during which, if severe skin reactions such as skin itching, redness and swelling, peeling and the like occur, whether to continue the test is determined according to specific conditions. Experimental procedures the number of people in each group of subjects who experienced itching, redness, peeling, and other discomfort such as stinging was counted at ambient room temperature (22-25 deg.C) and humidity (45-60%) and the results are shown in Table 2.
TABLE 2
| Sample (I) | Itching (pruritus) | Red swelling and pain | Peeling off | Other discomfort |
| Test 1 group | 0 | 0 | 0 | 0 |
| Experiment 2 groups | 2 | 1 | 0 | 1 |
The results show that: the water-in-oil type skin cream can effectively reduce the sensitivity of physical sunscreen agents and chemical sunscreen agents to skin, and obviously improve pruritus, redness, swelling, desquamation and discomfort.
Test example 4
The feeling of use of the water-in-oil type skin cream of the present invention was evaluated.
Randomly selecting 30 subjects, cleaning the face for 5min, smearing 2 pumps of the water-in-oil type skin cream prepared in the embodiment 1 of the invention on the face, filling in a questionnaire after 30min, and counting to obtain results shown in table 3.
TABLE 3
The results show that: the texture, touch and skin feel of the water-in-oil type skin cream meet the requirements of consumers.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. The sialic acid-containing water-in-oil type skin cream is characterized by comprising the following raw materials in percentage by weight: 0.1-2% of sialic acid, 0.1-1% of bisabolol, 0.1-1% of vitamin E, 3-10% of emulsifier, 20-35% of grease, 3-10% of sun-screening agent, 10-20% of glycerol, 1-10.5% of auxiliary material and the balance of deionized water.
2. The sialic acid containing water-in-oil skin cream of claim 1, wherein the emulsifier comprises a mixture of (1-4): (1-3): (1-3) cetyl polyethylene glycol/polypropylene glycol-10/1 dimethicone, lauryl alcohol PEG-9 dimethiconoethyl dimethicone, and sorbitan sesquioleate.
3. The sialic acid containing water-in-oil type skin cream according to claim 1 or 2, wherein the oil comprises one or both of isomeric hexadecane and polydimethylsiloxane.
4. The sialic acid-containing water-in-oil skin cream according to claim 3, wherein the oil comprises (1-1.5): the isomeric hexadecanes and polydimethylsiloxanes of (1-2).
5. The sialic acid containing water-in-oil skin cream of any one of claims 1-4, wherein the sunscreen agent comprises one or more of magnesium stearate, zinc oxide, methylene bis-benzotriazole tetramethyl butyl phenol, lipophilic titanium dioxide.
6. The sialic acid containing water-in-oil skin cream of claim 5, wherein the sunscreen agent comprises (0.5-4): (1-2): (0.5-2): (1-2) magnesium stearate, zinc oxide, methylene bis-benzotriazole tetramethylbutylphenol, and oleophilic titanium dioxide.
7. The sialic acid containing water-in-oil type skin cream according to any one of claims 1 to 6, wherein the adjuvant comprises 0.15 to 1.5% of a thickener, 0.05 to 3% of a neutralizer, 0.1 to 0.5% of a metal complexing agent, 0.5 to 3% of a metal salt stabilizer, and 0.2 to 1% of a preservative.
8. The sialic acid containing water-in-oil skin cream of claim 7, wherein the thickener is a mixture of (0.1-1): xanthan gum and acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer (0.05-0.5);
and/or the neutralizing agent is triethanolamine;
and/or the metal complexing agent is EDTA-2 Na;
and/or the metal salt stabilizer is magnesium sulfate;
and/or, the preservative IS selected from Germall IS-45 and/or methylparaben.
9. The sialic acid containing water-in-oil skin cream according to claim 1, wherein the water-in-oil skin cream comprises the following raw materials in percentage by weight: 0.1-2% of sialic acid, 0.1-1% of bisabolol, 0.1-1% of vitamin E, 1-4% of cetyl polyethylene glycol/polypropylene glycol-10/1 dimethyl siloxane, 1-3% of lauryl alcohol PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 1-3% of sorbitan sesquioleate, 10-15% of isomeric hexadecane, 10-20% of polydimethylsiloxane, 0.5-4% of magnesium stearate, 1-2% of zinc oxide, 0.5-2% of methylene bis-benzotriazole tetramethylbutylphenol, 1-2% of lipophilic titanium dioxide, 10-20% of glycerol, 0.1-1% of xanthan gum, 0.05-0.5% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.05-3% of triethanolamine, 0.1-0.5% of EDTA-2Na, 0.5-3% of magnesium sulfate, 450.1-0.5% of Germall IS-450, 0.1-0.5% of methyl hydroxybenzoate and the balance of deionized water.
10. A method for preparing a sialic acid containing water-in-oil type skin cream according to any one of claims 1 to 9, comprising the steps of:
(1) weighing the raw materials according to the weight percentage for later use;
(2) putting deionized water, sialic acid, glycerol, a metal complexing agent, a metal salt stabilizer and a thickening agent into a stirring pot, heating to 75-85 ℃ while stirring to fully dissolve the sialic acid, and preserving heat for 5-15 minutes to obtain a phase A;
(3) mixing magnesium stearate, zinc oxide, oleophylic titanium dioxide and grease uniformly, grinding for three times by using a three-roll grinder, and obtaining a B phase after confirming that the mixture is uniform and has no particles;
(4) adding emulsifier, bisabolol, vitamin E, and methylene bis-benzotriazole tetramethyl butyl phenol into another stirring pot, heating to 75-85 deg.C while stirring, dissolving completely, and keeping the temperature for 5-15 min to obtain phase C;
(5) preheating an emulsifying pot to 75-80 ℃, vacuumizing to-0.03 MPa, pumping the phase A, the phase B and the phase C into the emulsifying pot, and homogenizing and emulsifying for 5-15 minutes;
(6) cooling to 46 deg.C at a rate of 1 deg.C per minute, adding neutralizer and antiseptic, and stirring;
(7) cooling to 36 deg.C at a rate of 1 deg.C per minute, vacuumizing, and discharging.
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| CN102665650A (en) * | 2009-11-27 | 2012-09-12 | 株式会社爱茉莉太平洋 | Cosmetic composition stabilized higher oily part |
| CN104042512A (en) * | 2014-06-23 | 2014-09-17 | 诺斯贝尔(中山)无纺日化有限公司 | Water-permeable refreshing/moisturizing/sunblocking skin cream |
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| CN110755349A (en) * | 2019-11-27 | 2020-02-07 | 欧露莲生物科技(广东)有限公司 | Allicin shining pigment cream and preparation method thereof |
| CN110946813A (en) * | 2019-11-12 | 2020-04-03 | 澳宝化妆品（惠州）有限公司 | Compound fermentation extract containing cubilose and preparation method and application thereof |
| CN111067102A (en) * | 2019-12-30 | 2020-04-28 | 嘉必优生物技术（武汉）股份有限公司 | Method for improving stability of N-acetylneuraminic acid aqueous solution |
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| CN102665650A (en) * | 2009-11-27 | 2012-09-12 | 株式会社爱茉莉太平洋 | Cosmetic composition stabilized higher oily part |
| CN104083291A (en) * | 2014-06-16 | 2014-10-08 | 武汉中科光谷绿色生物技术有限公司 | Application of N-acetylneuraminic acid monomer or its hydrate in cosmetics |
| CN104042512A (en) * | 2014-06-23 | 2014-09-17 | 诺斯贝尔(中山)无纺日化有限公司 | Water-permeable refreshing/moisturizing/sunblocking skin cream |
| CN110946813A (en) * | 2019-11-12 | 2020-04-03 | 澳宝化妆品（惠州）有限公司 | Compound fermentation extract containing cubilose and preparation method and application thereof |
| CN110755349A (en) * | 2019-11-27 | 2020-02-07 | 欧露莲生物科技(广东)有限公司 | Allicin shining pigment cream and preparation method thereof |
| CN111067102A (en) * | 2019-12-30 | 2020-04-28 | 嘉必优生物技术（武汉）股份有限公司 | Method for improving stability of N-acetylneuraminic acid aqueous solution |
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| CN117122044A (en) * | 2023-08-25 | 2023-11-28 | 合肥工业大学 | Double gel and preparation method and application thereof |
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| CN114344189B (en) | 2023-09-26 |
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