CN114343834B - Pulse ablation control device and pulse ablation system - Google Patents
Pulse ablation control device and pulse ablation system Download PDFInfo
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- CN114343834B CN114343834B CN202111545316.5A CN202111545316A CN114343834B CN 114343834 B CN114343834 B CN 114343834B CN 202111545316 A CN202111545316 A CN 202111545316A CN 114343834 B CN114343834 B CN 114343834B
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Abstract
The embodiment of the specification provides a pulse ablation control device and a pulse ablation system. The control device comprises a power supply module, a high-voltage pulse module and a control module, wherein the power supply module is respectively and electrically connected with the high-voltage pulse module and the control module, the high-voltage pulse module is electrically connected with the control module, and the high-voltage pulse module is electrically connected with the ablation electrode; the control module is used for acquiring pulse electric parameters corresponding to the target focus and controlling the power supply module and the high-voltage pulse module according to the pulse electric parameters; the power supply module generates a continuously adjustable electric signal corresponding to the pulse electric parameter and provides the electric signal to the high-voltage pulse module; the high-voltage pulse module converts the electric signal into a high-voltage pulse signal and applies the high-voltage pulse signal to the ablation electrode so as to perform pulse ablation on the target focus discharge. By generating continuously adjustable pulse voltage, the optimal amplitude voltage which accords with the characteristics of cells is output, the operation effect is improved, and the damage to the human body is reduced.
Description
Technical Field
The present disclosure relates to the field of medical devices, and in particular, to a pulse ablation control device and a pulse ablation system.
Background
In the current society, the number of patients suffering from arrhythmia increases year by year. High pressure pulse ablation is a commonly used method of treating tachyarrhythmia. The high-voltage pulse ablation method is to release extremely high energy in a short time by generating a high-voltage pulse electric field with a pulse width of millisecond, microsecond or even nanosecond, so that cell walls are broken, a large number of irreversible micropores are formed, cell fluid is lost, and death of focus cells is realized, so that the expected treatment effect is achieved.
According to cell characteristics and clinical data analysis, the tolerating voltages of cells of different human tissue parts are different, so that treatment difficulty is brought to pulse ablation, and if the pulse voltage is too low, ablation treatment is not thorough, so that sequelae or other complications are caused; if the pulse voltage is too high, normal cells are damaged, creating unnecessary damage.
Disclosure of Invention
In view of this, the embodiments of the present disclosure provide a pulse ablation control device and a pulse ablation system, in which the pulse ablation control device can output voltages with optimal amplitudes according to cells at different positions, kill focal cells, and avoid damaging normal cells.
The embodiment of the specification provides the following technical scheme:
a pulse ablation control device comprising: the high-voltage pulse device comprises a power supply module, a high-voltage pulse module and a control module, wherein the power supply module is respectively and electrically connected with the high-voltage pulse module and the control module, the high-voltage pulse module is electrically connected with the control module, and the high-voltage pulse module is electrically connected with an ablation electrode;
the control module is used for acquiring pulse electric parameters corresponding to a target focus and controlling the power supply module and the high-voltage pulse module according to the pulse electric parameters;
the power supply module is used for generating a continuously adjustable electric signal corresponding to the pulse electric parameter under the control of the control module and providing the electric signal to the high-voltage pulse module;
the high-voltage pulse module is used for converting the electric signal into a high-voltage pulse signal under the control of the control module, and applying the high-voltage pulse signal to the ablation electrode so as to perform pulse ablation on the target focus discharge.
In the scheme, the control module is respectively and electrically connected with the power module and the high-voltage pulse module to control, pulse parameters are acquired through the control module, and continuous adjustable electric signals are generated at the power module, so that high-voltage pulse signals are generated through conversion of the high-voltage pulse module, the optimal amplitude voltage meeting the requirement of killing focus cells is obtained, the focus cells are accurately released to a focus area, normal cells are prevented from being damaged, the pulse ablation operation effect is improved, and operation damage is reduced.
The embodiment of the specification also provides a scheme, wherein the power supply module comprises a direct current module and an inversion module, the direct current module is electrically connected with the inversion module, and the inversion module is electrically connected with the high-voltage pulse module; the control module is respectively and electrically connected with the direct current module and the inversion module;
the power module is used for generating a continuously adjustable electric signal corresponding to the pulse electric parameter under the control of the control module, and providing the electric signal to the high-voltage pulse module, and comprises:
the direct current module generates a continuous adjustable electric signal corresponding to the pulse electric parameter under the control of the control module, and the inversion module inverts the electric signal and provides the electric signal to the high-voltage pulse module so that the high-voltage pulse module converts the inverted electric signal into a high-voltage pulse signal;
and/or the direct current module provides continuous electric signals for the inversion module under the control of the control module, and the inversion module inverts and adjusts the voltage of the continuous electric signals through PWM (pulse width modulation) under the control of the control module to generate continuous adjustable electric signals corresponding to the pulse electric parameters and provides the continuous adjustable electric signals for the high-voltage pulse module so that the high-voltage pulse module converts the inverted continuous adjustable electric signals into high-voltage pulse signals.
The embodiment of the specification also provides a scheme, wherein the high-voltage pulse module comprises a boosting module and a rectifying module;
the power supply module is electrically connected with the boosting module, and the boosting module is electrically connected with the rectifying module;
the electric signal sequentially passes through the voltage boosting module to modulate voltage, and the rectifying module performs alternating current-direct current conversion to generate the high-voltage pulse signal.
The embodiment of the specification also provides a scheme, wherein the high-voltage pulse module further comprises a charge pump module, and the charge pump module is electrically connected with the rectification module so as to store and/or transform high-voltage pulse energy of the high-voltage pulse signal output by the rectification module.
The embodiment of the specification also provides a scheme, when the ablation electrodes are multiple, the pulse ablation control device further comprises a pulse switching module, the high-voltage pulse module is electrically connected with the ablation electrodes through the pulse switching module, and the pulse switching module is electrically connected with the control module;
the high-voltage pulse signal output by the high-voltage pulse module comprises a high-voltage positive pulse and a high-voltage negative pulse, and the pulse switching module is used for outputting the high-voltage positive pulse or the high-voltage negative pulse to the ablation electrode under the control of the control module.
The embodiment of the specification also provides a scheme, wherein the pulse switching module comprises a plurality of switches, and two ends of each switch are respectively and electrically connected with one ablation electrode;
the switch is used for outputting high-voltage positive pulses or high-voltage negative pulses to the connected ablation electrode under the control of the control module.
The embodiment of the specification also provides a scheme, wherein the control device further comprises a data acquisition module, and the data acquisition module is electrically connected with the control module;
the control module is used for acquiring pulse electric parameters corresponding to a target focus, and comprises the steps that the data acquisition module acquires electrophysiological characteristics of the target focus and transmits the electrophysiological characteristics to the control module.
The embodiment of the specification also provides a scheme, wherein the control module comprises a first control unit and a second control unit, and the first control unit and the second control unit are respectively used for enabling the high-voltage pulse module;
the high-voltage pulse module is used for applying the high-voltage pulse signal to the ablation electrode under the control of the control module, and comprises the following components: the high-voltage pulse module outputs a high-voltage positive pulse or a high-voltage negative pulse to the connected ablation electrode when the first control unit and the second control unit are enabled at the same time.
The embodiment of the specification also provides a scheme that the controller of the first control unit and the controller of the second control unit are different controllers.
The embodiment of the specification also provides a pulse ablation system, an ablation catheter and a pulse ablation control device according to any one of the previous claims, wherein the ablation catheter is connected with the pulse ablation control device.
Compared with the prior art, the beneficial effects that above-mentioned at least one technical scheme that this description embodiment adopted can reach include at least: after the pulse parameters corresponding to the target focus are obtained through the control module, the power module and the high-voltage pulse module are controlled, so that the power module generates a continuous adjustable electric signal corresponding to the pulse electric parameters, the continuous adjustable electric signal is provided for the high-voltage pulse module, the high-voltage pulse module converts and generates a high-voltage pulse signal, the high-voltage pulse signal is released to a focus area through an ablation electrode connected with the high-voltage pulse module, and accordingly the optimal amplitude voltage meeting the requirement of killing focus cells is released to the target focus, normal cells are prevented from being damaged.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic circuit diagram of a pulse ablation control device;
FIG. 2 is a schematic circuit diagram of a pulse ablation control device that produces a continuously adjustable electrical signal at the output of a DC power module;
FIG. 3 is a schematic circuit diagram of a pulse ablation control device employing digital-to-analog conversion;
FIG. 4 is a schematic circuit diagram of a pulse ablation control device that produces a continuously adjustable electrical signal at the output of an inverter module;
FIG. 5 is a schematic circuit diagram of a pulse ablation control device including a half-bridge inverter module;
FIG. 6 is a schematic circuit diagram of a pulse ablation control device including a boost module, a rectifier module, and a charge pump module;
FIG. 7 is a schematic circuit diagram of a pulse ablation control apparatus including a pulse switching module;
FIG. 8 is a schematic circuit diagram of a pulse switching module connected to a multiplexing circuit;
FIG. 9 is a schematic circuit diagram of a pulse ablation control device including a data acquisition module;
FIG. 10 is a schematic circuit diagram of a control module including two independent control units;
the device comprises a control module (10), a first control unit (11), a second control unit (12), a 13, a digital-to-analog conversion module (13), a 20, a power module (21), a first direct current module (22), a first inversion module (23), a second direct current module (24), a second inversion module (241), a half-bridge inversion module (25), a direct current module (26), an inversion module (30), a high-voltage pulse module (31), a boosting module (32), a rectifying module (33), a charge pump module (40), a pulse switching module (50), a data acquisition module (60) and an ablation electrode.
Detailed Description
Embodiments of the present application are described in detail below with reference to the accompanying drawings.
Other advantages and effects of the present application will become apparent to those skilled in the art from the present disclosure, when the following description of the embodiments is taken in conjunction with the accompanying drawings. It will be apparent that the described embodiments are only some, but not all, of the embodiments of the present application. The present application may be embodied or carried out in other specific embodiments, and the details of the present application may be modified or changed from various points of view and applications without departing from the spirit of the present application. It should be noted that the following embodiments and features in the embodiments may be combined with each other without conflict. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without making any inventive effort, are intended to be within the scope of the present application.
It is noted that various aspects of the embodiments are described below within the scope of the following claims. It should be apparent that the aspects described herein may be embodied in a wide variety of forms and that any specific structure and/or function described herein is merely illustrative. Based on the present application, one skilled in the art will appreciate that one aspect described herein may be implemented independently of any other aspect, and that two or more of these aspects may be combined in various ways. For example, apparatus may be implemented and/or methods practiced using any number and aspects set forth herein. In addition, such apparatus may be implemented and/or such methods practiced using other structure and/or functionality in addition to one or more of the aspects set forth herein.
It should also be noted that the illustrations provided in the following embodiments merely illustrate the basic concepts of the application by way of illustration, and only the components related to the application are shown in the drawings and are not drawn according to the number, shape and size of the components in actual implementation, and the form, number and proportion of the components in actual implementation may be arbitrarily changed, and the layout of the components may be more complicated.
In addition, in the following description, specific details are provided in order to provide a thorough understanding of the examples. However, it will be understood by those skilled in the art that the aspects may be practiced without these specific details.
The heart pulse electric field ablation is an ablation mode using a pulse field as energy, has preferential selectivity on myocardial tissues, and has the characteristics of instantaneous energy release, difficult damage to adjacent tissue organs and the like by using non-thermal energy ablation. The high-voltage pulse ablation is to release extremely high energy in a short time by generating a high-voltage pulse electric field with a pulse width of millisecond, microsecond or even nanosecond, so that cell walls are broken, a large number of irreversible micropores are formed, cell fluid is lost, and death of focus cells is realized, so that the expected treatment effect is achieved.
According to the research and analysis of the cell characteristics and clinical research data, the cell tolerance voltage parameters of different human tissue positions are different, and in order to achieve a good treatment effect, the voltage with the optimal amplitude is required to be output according to different cell characteristic voltages, so that cells in a focus area are killed, and meanwhile, the healthy cells are not greatly influenced.
Based on the clinical requirements and technical characteristics, the inventor provides a pulse ablation control system with continuously adjustable output voltage range, wherein a low-voltage power module is electrically connected with a high-voltage pulse module, the modules are managed by using the control module, pulse electric parameters of a focus area are collected by using a control device, continuously adjustable electric signals are output according to the pulse electric parameters to control the low-voltage power module, the electric signals are boosted by using the high-voltage pulse module and then released to the focus area, so that the output voltage of the high-voltage pulse is continuously adjustable, the characteristics of cells in different focus areas are met, and the output voltage meets the optimal amplitude voltage for ablating the cells in the area.
The following describes the technical solutions provided by the embodiments of the present application with reference to the accompanying drawings.
The pulse ablation control device shown in fig. 1 comprises a power module 20, a high-voltage pulse module 30 and a control module 10, wherein the power module 20 is respectively and electrically connected with the high-voltage pulse module 30 and the control module 10, the high-voltage pulse module 30 is electrically connected with the control module 10, and the high-voltage pulse module 30 is electrically connected with an ablation electrode 60. The control module 10 performs two operations, including the control module 10 obtaining the pulse electrical parameters corresponding to the target lesion and controlling the power module 20 and the high-voltage pulse module 30 according to the pulse electrical parameters, where it should be noted that the two operations of the control module 10 may be continuous operation modes or circulating operation modes. It should be further noted that, the method of acquiring the pulse electrical parameter of the target lesion includes a direct measurement method, for example, acquiring the cell resistance of the lesion area, and may also include an indirect measurement method, for example, acquiring the current and/or voltage of the ablation electrode, and the specific acquisition method is not limited herein. The power module 20 is configured to generate a continuously adjustable electrical signal corresponding to the pulse electrical parameter under the control of the control module 10 and provide the electrical signal to the high voltage pulse module 30. The high-voltage pulse module 30 is configured to convert the electrical signal into a high-voltage pulse signal under the control of the control module 10, for example, to increase the voltage by using a voltage transformation method or a capacitive energy storage method, and apply the high-voltage pulse signal to the ablation electrode 60, and release energy through the ablation electrode to perform pulse ablation on the target lesion discharge.
The control module controls the power module and the high-voltage pulse module according to pulse electric parameters of a target focus, generates a continuously adjustable electric signal at the power module, converts the electric signal into a high-voltage pulse signal by the high-voltage pulse module, further generates a high-voltage pulse with continuously adjustable output voltage, outputs an optimal amplitude voltage which accords with cells in an ablation area through the ablation electrode, achieves a good treatment effect, and avoids damaging normal cells.
In some embodiments, as shown in fig. 2, the power module 20 includes a first dc module 21 and a first inverter module 22, the first dc module 21 is electrically connected to the first inverter module 22, the first inverter module 22 is electrically connected to the high voltage pulse module 30, and the control module 10 is electrically connected to the first dc module 21 and the first inverter module 22, respectively. The first direct current module 21 generates a continuously adjustable electric signal corresponding to the pulse electric parameter under the control of the control module 10, and the first inversion module 22 inverts the electric signal and provides the electric signal to the high-voltage pulse module 30, so that the high-voltage pulse module 30 converts the inverted electric signal into a high-voltage pulse signal.
Optionally, the communication interface of the control module 10 is connected to the feedback end of the first direct current module 21, so as to realize continuous adjustable output voltage of the first direct current module 21.
For example, as shown in fig. 3, the input voltage of the first dc module 21 is 48V, the communication interface of the control module 10 is an SPI serial bus, the SPI serial bus is electrically connected to the digital-to-analog conversion module 13 (i.e., DAC module), and the digital-to-analog conversion module 13 is connected to the feedback end of the first dc module 21, so as to realize continuous adjustability of the output voltage of the first dc module 21 in the range of 0 to 45V.
Alternatively, the first inverter module 22 includes a half-bridge inverter circuit or a full-bridge inverter circuit.
In some embodiments, as shown in fig. 4, the power module 20 includes a second dc module 23 and a second inverter module 24, the second dc module 23 is electrically connected to the second inverter module 24, the second inverter module 24 is electrically connected to the high voltage pulse module 30, the control module 10 is electrically connected to the second dc module 23 and the second inverter module 24, the second dc module 23 generates a continuous electric signal under the control of the control module 30, and the second inverter module 24 generates a continuous adjustable electric signal corresponding to the pulse electric parameter after inverting and voltage-adjusting the continuous electric signal by PWM under the control of the control module 10, and provides the continuous adjustable electric signal to the high voltage pulse module 30, so that the high voltage pulse module 30 converts the continuous adjustable electric signal into a high voltage pulse signal.
Optionally, the second inverter module 24 includes a half-bridge inverter circuit or a full-bridge inverter circuit.
Alternatively, by controlling the switching frequency of the second inverter module 24, the output voltage of the second inverter module 24 is continuously adjustable.
For example, as shown in fig. 5, the second inverter module 24 is a half-bridge inverter module 241, that is, the power module 20 includes the second dc module 23 and the half-bridge inverter module 241, the second dc module 23 is electrically connected to the half-bridge inverter module 241, the half-bridge inverter module 241 is electrically connected to the high-voltage pulse module 30, the control module 10 is electrically connected to the second dc module 23 and the half-bridge inverter module 241, and by changing the duty ratio of the PWM signal sent by the control module 10 to the half-bridge inverter module 241, the output voltage of the half-bridge inverter module 241 can be continuously adjusted.
In some embodiments, as shown in fig. 6, the high-voltage pulse module includes a boost module 31 and a rectifying module 32, the direct-current module 25 is electrically connected to the inverting module 26, the inverting module 26 is electrically connected to the boost module 31, the boost module 31 is electrically connected to the rectifying module 32, the control module 10 is electrically connected to the direct-current module 25 and the inverting module 26 respectively, and an electrical signal with continuously adjustable voltage can be output at an output end of the inverting module 26, and a manner of generating the electrical signal with continuously adjustable voltage is referred to the foregoing embodiment and will not be described herein. The electric signal with continuously adjustable voltage sequentially passes through the voltage boosting module 31 to modulate the voltage, and the rectifying module 32 performs alternating current-direct current conversion to generate a high-voltage pulse signal, and the high-voltage pulse signal is released through the ablation electrode to perform ablation treatment.
Preferably, as shown in fig. 6, the high voltage pulse module 30 further includes a charge pump module 33, and the charge pump module 33 is electrically connected to the rectifying module 32 to store and/or transform the high voltage pulse energy of the high voltage pulse signal output by the rectifying module 32.
It should be noted that, the control module 10 may be electrically connected to any one or any plurality of the boost module 31, the rectifying module 32, and the charge pump module 33 according to control requirements, for example: the control module 10 is electrically connected to the boost module 31 (not shown in the drawings); alternatively, the control module 10 is electrically connected to the charge pump module 33 (as shown in fig. 6) to control the charge pump module 33 to discharge the pulse energy; alternatively, the control module 10 is electrically connected to the rectifying module 32 and the charge pump module 33, respectively.
Optionally, the boost module 31 includes a transformer, a bootstrap circuit, and the like.
Optionally, the rectifying module 32 includes a half-wave rectifying circuit, a full-wave bridge rectifying circuit, and the like.
Optionally, the charge pump module 33 includes a switching regulator booster pump, a non-regulated capacitive charge pump, an adjustable capacitive charge pump.
In some embodiments, the pulse ablation device has a plurality of ablation electrodes, such as an ablation catheter, with a ring-shaped member on which are disposed a plurality of ablation electrodes for delivering pulsed ablation energy, at which time the pulse ablation control apparatus further includes a pulse switching die 40, used in combination with a plurality of ablation electrodes, capable of delivering positive or negative pulses on different electrodes.
As shown in fig. 7, the high-voltage pulse module 30 is electrically connected to the pulse switching module 40, the pulse switching module 40 is electrically connected to the ablation electrode 60, the control module 10 is electrically connected to the pulse switching module 40, and the pulse switching module 40 is configured to output high-voltage positive pulses and/or high-voltage negative pulses to the ablation electrode 60 under the control of the control module 10.
It should be noted that, the high voltage pulse module 30 may also output a high voltage positive pulse and a high voltage negative pulse under the control of the control module 10, for example, the control module 10 is electrically connected to the charge pump module 33, and outputs the high voltage positive pulse and/or the high voltage negative pulse by controlling the charge pump module 33, for example: two separate charge pump circuits are used, wherein a first positive high voltage charge pump is used for generating positive high voltage and a second negative high voltage charge pump is used for generating negative high voltage, and the operation conditions of the two charge pump circuits are controlled by the control module 10, and high voltage positive pulses and/or high voltage negative pulses are output. The control module is used for controlling the pulse output mode of the ablation electrode, and the control module is used for controlling the pulse output mode of the ablation electrode.
In some embodiments, as shown in fig. 8, the pulse switching module 40 includes a plurality of switches, and two ends of each switch are electrically connected with one of the ablation electrodes;
the switch is used to output a high voltage positive pulse or a high voltage negative pulse to the connected ablation electrode under the control of the control module 10.
Preferably, the switch is a single-pole double-throw relay, as shown in fig. 8, and positive and negative pulse output between any two or more output electrodes can be realized by using the relay, as shown in fig. 8, the pulse switching module 40 is connected with a high-voltage positive pulse circuit and a high-voltage negative pulse circuit, which are connected with each other by using the relayBetween which a multiplexing circuit (i.e. OUT in FIG. 8 is arranged 1 To OUT n ) Each circuit is sequentially connected with a relay A in series n Ablation electrode, relay B n . At this time, if relay A 1 Connect with high voltage positive pulse, relay B 5 The high-voltage negative pulse is connected, the rest relays are connected with the suspension end, and the pulse switching module 40 is arranged in the output circuit OUT 1 And OUT 5 Outputting high-voltage positive pulse; if relay B is to be used 1 High-voltage negative pulse is connected with relay A 2 The pulse switching module 40 is connected with the output circuit OUT and connected with the high-voltage positive pulse and the other relays are connected with the suspension end 1 And OUT 2 Outputting high-voltage negative pulse; if relay A is to be used 1 And relay A 3 Connect with high voltage positive pulse, relay B 1 And relay B 4 The high-voltage negative pulse is connected, the rest relays are connected with the suspension end, and the pulse switching module 40 is arranged in the output circuit OUT 1 And OUT 3 Between, OUT 2 And OUT 4 And simultaneously outputs high-voltage positive pulses.
In some embodiments, the pulse ablation control device as shown in fig. 9 further comprises a data acquisition module 50, the data acquisition module 50 is electrically connected to the control module 10, and the data acquisition module 50 is configured to acquire electrophysiological characteristics of the target lesion and transmit the electrophysiological characteristics to the control module 10.
Optionally, acquiring electrophysiological characteristics of the target lesion includes: by using the mapping catheter, the data acquisition module 50 directly acquires the current value and/or voltage value of the target lesion; the data acquisition module 50 is electrically connected with the ablation electrode 60 to acquire a current value and/or a voltage value on the ablation electrode which is close to the target focus; the data acquisition module 50 is electrically connected to the pulse switching module 40 to acquire the feedback current value and/or voltage value on the pulse switching module 40.
The electrophysiological characteristics of the target focus are acquired by the data acquisition module, measurement data can be fed back to the control module in time, the control module calculates impedance characteristic data to focus cells according to the measurement data by a built-in or external calculation method, the control module adjusts the output voltage of the power supply module in time according to the impedance characteristic data so as to output pulses with optimal amplitude according with the impedance characteristics of the focus cells at the high-voltage pulse module, thereby realizing effective ablation of the focus cells and protection of normal cells and improving treatment effect.
In some embodiments, as shown in fig. 10, the control module 10 includes a first control unit 11 and a second control unit 12, the first control unit 11 and the second control unit 12 being connected to the high voltage pulse module 30, respectively, and capable of enabling the high voltage pulse module 30, respectively, and outputting a high voltage positive pulse or a high voltage negative pulse to the connected ablation electrode 60 when the high voltage pulse module 30 is simultaneously enabled at the first control unit 11 and the second control unit 12.
The pulse voltage used in the pulse ablation operation is high, a kilovolt-level pulse electric field is used, and by arranging two control units for controlling the high-voltage pulse module to enable in the control units, the high-voltage pulse can be allowed to be released only when the two control units are enabled at the same time, so that the occurrence of accidental pulse release is prevented, and the safety of patients and the operation is protected.
Preferably, the first control unit 11 and the second control unit 12 are different controllers. For example: the first control unit 11 is a Field Programmable Gate Array (FPGA) chip; the second control unit 12 is a Micro Control Unit (MCU). Further, controlling the pulse width through an FPGA chip; the pulse width and the pulse number are independently controlled by the MCU to provide better stability for a control system. Similarly, the FPGA chip and the MCU may be connected to the high voltage pulse module 30, respectively, and the high voltage pulse module 30 may output a high voltage positive pulse or a high voltage negative pulse only when the FPGA chip and the MCU are both enabled.
Based on the same inventive concept, the embodiments of the present disclosure further provide a pulse ablation system, which includes an ablation catheter and the pulse ablation control device according to any one of the foregoing, wherein the ablation catheter is connected to the pulse ablation control device.
In this specification, each embodiment is described in a progressive manner, and identical and similar parts of each embodiment are all referred to each other, and each embodiment focuses on differences from other embodiments. In particular, for the method embodiments described later, since they correspond to the system, the description is relatively simple, and reference should be made to the description of some of the system embodiments.
The foregoing is merely specific embodiments of the present application, but the scope of the present application is not limited thereto, and any changes or substitutions easily conceivable by those skilled in the art within the technical scope of the present application should be covered in the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (9)
1. A pulse ablation control apparatus, comprising: the high-voltage pulse device comprises a power supply module, a high-voltage pulse module and a control module, wherein the power supply module is respectively and electrically connected with the high-voltage pulse module and the control module, the high-voltage pulse module is electrically connected with the control module, and the high-voltage pulse module is electrically connected with an ablation electrode;
the control module is used for acquiring pulse electric parameters corresponding to a target focus, and controlling the power supply module and the high-voltage pulse module according to the pulse electric parameters and different cell characteristic voltages so as to output the voltage with the optimal amplitude; the control module comprises a first control unit and a second control unit, wherein the controller of the first control unit and the controller of the second control unit are different controllers;
the power supply module is used for generating a continuously adjustable electric signal corresponding to the pulse electric parameter under the control of the control module and providing the electric signal to the high-voltage pulse module; the power module comprises a direct current module and an inversion module, wherein the direct current module is electrically connected with the inversion module, and the inversion module is electrically connected with the high-voltage pulse module; the control module is respectively and electrically connected with the direct current module and the inversion module; the direct current module comprises a first direct current module and a second direct current module, and the inversion module comprises a first inversion module and a second inversion module; the feedback end of the first direct current module is connected through the communication interface of the control module, so that the output voltage of the first direct current module is continuously adjustable; the switching frequency of the second inversion module is controlled, so that the output voltage of the second inversion module is continuously adjustable;
the high-voltage pulse module is used for converting the electric signal into a high-voltage pulse signal under the control of the control module, and applying the high-voltage pulse signal to the ablation electrode so as to perform pulse ablation on the target focus discharge.
2. The pulse ablation control device of claim 1, wherein the pulse ablation control device comprises,
the power module is used for generating a continuously adjustable electric signal corresponding to the pulse electric parameter under the control of the control module, and providing the electric signal to the high-voltage pulse module, and comprises:
the direct current module generates a continuous adjustable electric signal corresponding to the pulse electric parameter under the control of the control module, and the inversion module inverts the electric signal and provides the electric signal to the high-voltage pulse module so that the high-voltage pulse module converts the inverted electric signal into a high-voltage pulse signal;
and the direct current module is controlled by the control module to provide continuous electric signals for the inversion module, and the inversion module is controlled by the control module to invert and regulate the voltage of the continuous electric signals through PWM, then generate continuous adjustable electric signals corresponding to the pulse electric parameters and provide the continuous adjustable electric signals for the high-voltage pulse module so that the high-voltage pulse module converts the inverted continuous adjustable electric signals into high-voltage pulse signals.
3. The pulse ablation control device of claim 1, wherein the high voltage pulse module comprises a boost module and a rectification module;
the power supply module is electrically connected with the boosting module, and the boosting module is electrically connected with the rectifying module;
the electric signals are boosted by the boosting module in sequence, and the rectifying module generates the high-voltage pulse signals from the electric signals output by the boosting module.
4. The pulse ablation control apparatus of claim 3, wherein the high voltage pulse module further comprises a charge pump module electrically connected to the rectification module for high voltage pulse energy storage and/or conversion of the high voltage pulse signal output by the rectification module.
5. The pulse ablation control device of claim 1, wherein when the ablation electrode is a plurality of, the pulse ablation control device further comprises a pulse switching module, the high voltage pulse module is electrically connected with the ablation electrode through the pulse switching module, the pulse switching module is electrically connected with the control module;
the high-voltage pulse signal output by the high-voltage pulse module comprises a high-voltage positive pulse and a high-voltage negative pulse, and the pulse switching module is used for outputting the high-voltage positive pulse or the high-voltage negative pulse to the ablation electrode under the control of the control module.
6. The pulse ablation control device of claim 5, wherein the pulse switching module comprises a plurality of switches, and two ends of each switch are respectively electrically connected with one ablation electrode;
the switch is used for outputting high-voltage positive pulses or high-voltage negative pulses to the connected ablation electrode under the control of the control module.
7. The pulse ablation control device of claim 1, further comprising a data acquisition module electrically connected to the control module;
the control module is used for acquiring pulse electric parameters corresponding to a target focus, and comprises the steps that the data acquisition module acquires electrophysiological characteristics of the target focus and transmits the electrophysiological characteristics to the control module.
8. The pulse ablation control apparatus of claim 1, wherein the first control unit and the second control unit are each configured to enable the high voltage pulse module;
the high-voltage pulse module is used for applying the high-voltage pulse signal to the ablation electrode under the control of the control module, and comprises the following components: the high-voltage pulse module outputs a high-voltage positive pulse or a high-voltage negative pulse to the connected ablation electrode when the first control unit and the second control unit are enabled at the same time.
9. A pulse ablation system comprising an ablation catheter and a pulse ablation control device according to any one of claims 1-8, wherein the ablation catheter is connected to the pulse ablation control device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111545316.5A CN114343834B (en) | 2021-12-16 | 2021-12-16 | Pulse ablation control device and pulse ablation system |
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| CN115005961B (en) * | 2022-07-07 | 2023-05-12 | 上海普实医疗器械股份有限公司 | Cardiac pulse electric field ablation system |
| CN116458993A (en) * | 2023-04-19 | 2023-07-21 | 上海玮启医疗器械有限公司 | Pulse ablation control system |
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| US10188449B2 (en) * | 2016-05-23 | 2019-01-29 | Covidien Lp | System and method for temperature enhanced irreversible electroporation |
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