CN114342816B - Device for testing analysis capability of experimental animal by using climbing ladder - Google Patents
Device for testing analysis capability of experimental animal by using climbing ladder Download PDFInfo
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- CN114342816B CN114342816B CN202111445521.4A CN202111445521A CN114342816B CN 114342816 B CN114342816 B CN 114342816B CN 202111445521 A CN202111445521 A CN 202111445521A CN 114342816 B CN114342816 B CN 114342816B
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Abstract
The invention relates to a device for testing analysis capability of experimental animals by using a climbing ladder. The device is as follows: (A) A transparent container capable of containing experimental animals and provided with an inlet and an outlet of the experimental animals and a reversed hemispherical transparent cover are respectively arranged in an opaque and semi-closed experimental animal movable space, the transparent cover is provided with the inlet and the outlet of the experimental animals facing away from the transparent container, the transparent cover is arranged on a platform with a certain height difference with the transparent container, and a climbing ladder is arranged between the transparent container and the platform; (B) the hemispherical transparent cover can be used for placing an attractant; (C) The test experimental animal is put into the transparent container, the attractants are found and positioned by using vision or smell, the test experimental animal climbs out of the transparent container, and the time of the process of finding the attractants by the climbing ladder is shortened. The invention relates to a device for testing the analysis capability of experimental animals by using a climbing ladder, which is simple and direct to operate.
Description
Technical Field
The invention relates to a device for testing analysis capability of experimental animals by using a climbing ladder. The invention mainly tests the time of the process that the experimental animal searches and positions the attractants in the transparent container by utilizing vision and then the attractants are found by climbing the ladder. This time was used as a measure for determining the analytical ability of the experimental animals. The method is used for testing the influence of foods and medicines on the analysis capability of experimental animals. The invention belongs to the field of food and medicine processing.
Background
The existing experimental animal testing device comprises: the Morris water maze test, the Y maze test, the tail suspension test, the overhead cross maze test, the open field test and other devices can be used for testing or verifying the influence of a target object on the intelligence, the memory, the fatigue resistance, the anxiety inhibition, the neuropsychiatric and the like of experimental animals.
The Morris water maze test is an experimental means applied to brain learning and memory mechanism research, a mouse can instinctively search a rest place in water, the behavior of searching the rest place involves a complex memory process, visual information related to space positioning is collected, the information is processed, arranged, memorized, reinforced and then taken out, the maze test does not have a visual front scene bedding, and even if the maze test is carried out on higher animals and human beings, the maze test also has necessary accidental factor interference. The analysis capability itself is considered, and the quantity of the preconditions is directly related to the final analysis effect result. Thus, the breaking capability test device should be a device with a perceivable precondition scene, including visual, auditory, etc.
However, there is no specific means for testing the analytical capabilities of the experimental animals. Analytical capability refers to the ability of an individual to effectively select and achieve a goal based on experience and related conditions that have been accumulated while facing the thing. The ability to analyze also belongs to one of the elements of intelligence in a sense, but is different from intelligence in a general sense. Intelligence refers to the integration of various cognitive abilities of individuals, particularly emphasizing the ability to solve new problems, abstract thinking, learning ability, and adaptability to the environment. Whereas analytical capabilities are practically distinguished from intelligence. If the analytical ability can be tested alone, the mental relevance factors can be further perceived in detail.
The enthusiasm of the knowledge of all age groups is continuously raised, the demands for the knowledge are increasingly obvious, and especially the coursework of children and teenagers is continuously increased. How to improve the analysis capability under high-intensity learning and working conditions has become a social need. Mainly has no simple and easy device for testing the analysis capability. Alternative means can adopt an electroencephalogram observation method, however, the method has high cost, and the observation index is not intuitive or difficult to determine.
Disclosure of Invention
The invention aims at a device for testing the analysis capability of experimental animals by using a climbing ladder, which is realized by the following device and method:
A. a transparent container capable of containing experimental animals and provided with an inlet and an outlet of the experimental animals and a reversed hemispherical transparent cover are respectively arranged in an opaque and semi-closed experimental animal movable space, the transparent cover is provided with the inlet and the outlet of the experimental animals facing away from the transparent container, the transparent cover is arranged on a platform with a certain height difference with the transparent container, and a climbing ladder is arranged between the transparent container and the platform;
B. the hemispherical transparent cover can be used for placing an attractant;
C. the test experimental animal is put into a transparent container, the attractants are found and positioned by utilizing vision or smell, the test experimental animal climbs out of the transparent container, and the time of the process of finding the attractants by a climbing ladder is shortened;
the transparent container in A is made of materials including, but not limited to, plastics, glass and acrylic plates;
the transparent cover material of the inverted hemispherical transparent cover in the A comprises, but is not limited to, plastic, glass and acrylic plates;
the transparent cover in the A is provided with an experimental animal inlet and outlet which is back to the transparent container, the direction of the inlet and outlet can be randomly adjusted, and the direction of the inlet and outlet is back to the transparent container with the experimental animal inlet and outlet when testing the analysis capability;
the transparent cover in the A is arranged on a platform with a certain height difference with the transparent container, and the height difference can not influence the vision of experimental animals to touch objects in the hemispherical transparent cover;
the hemispherical transparent cover in the step B can be used for placing attractants which can be objects or foods with different colors, shapes, odors and sound and light;
the time of the process of finding the attractants described in C was used as a measure for determining the analytical ability of the experimental animal.
Drawings
The invention comprises two figures, the figures of which are illustrated as follows:
FIG. 1 is a front view of an apparatus for testing the analytical capabilities of laboratory animals using a climbing ladder;
figure 2 is an example of the assay test time for three different assay capacity mice.
Detailed Description
The following examples serve to illustrate the invention, but in no way limit the scope of the invention,
example 1:
1) In an opaque and semi-closed experimental animal activity space, placing an experimental mouse in a transparent plastic container with an experimental animal inlet and outlet at the top and adapting to the environment for 6 hours, and replacing the experimental mouse;
2) Thoroughly hemispherical inner and outer parts of the plastic transparent cover by using cleaning liquid;
3) Placing a hemispherical plastic transparent cover with an entrance and an exit facing away from experimental animals on the platform, and placing mouse grains in the entrance and the exit facing away from the climbing ladder;
4) 24 h, placing the experimental mouse into a transparent plastic container with an inlet and an outlet of the experimental animal at the top, starting to record the foraging time (s, seconds), starting to time when the experimental mouse is placed into the transparent plastic container, and stopping and recording when the time for the experimental mouse to find the mouse grain and gnaw exceeds 1 s;
5) The above procedure was repeated for continuous test 21d, and the average of the foraging time of the mice was calculated as a measure of analytical ability, once every 4 th d th day.
Example 2:
1) In an opaque and semi-closed experimental animal activity space, putting an SD rat into a transparent acrylic plate container with an experimental animal inlet and outlet at the top, adapting to the environment for 6h, and putting back;
2) Thoroughly hemispherical inner and outer parts of the acrylic plate transparent cover by using cleaning liquid;
3) Placing a hemispherical acrylic plate transparent cover with an inlet and an outlet which are opposite to the experimental animal on the platform, and placing toy balls which can sound inside the inlet and the outlet which are opposite to the climbing ladder;
4) After 24 h, putting the SD rat into a transparent acrylic plate container with an inlet and an outlet of an experimental animal at the top, starting to record the foraging time (s, seconds), starting to time when the SD rat is put into the transparent acrylic plate container, and stopping and recording when the time for the experimental mouse to find a toy ball which can sound and keep the toy ball exceeds 1 s;
5) The above procedure was repeated for continuous test 21d, and the average of the foraging time of the mice was calculated as a measure of analytical ability, once every 4 th d th day.
Claims (7)
1. The device for testing the analysis capability of the experimental animal by using the climbing ladder is characterized by comprising the following steps:
A. a transparent container capable of containing experimental animals and provided with an inlet and an outlet of the experimental animals and a reverse hemispherical transparent cover are respectively arranged in an opaque and semi-closed experimental animal movable space, the hemispherical transparent cover is provided with the inlet and the outlet of the experimental animals facing away from the transparent container, the hemispherical transparent cover is arranged on a platform with a certain height difference from the transparent container, and a climbing ladder is arranged between the transparent container and the platform;
B. the hemispherical transparent cover can be used for placing an attractant;
C. the test experimental animal is put into the transparent container, the attractants are found and positioned by using vision or smell, the test experimental animal climbs out of the transparent container, and the time of the process of finding the attractants by the climbing ladder is shortened.
2. A device for testing the analytical capabilities of laboratory animals using a climbing ladder according to claim 1, wherein the transparent container comprises a material including but not limited to plastic, glass.
3. A device for testing the analytical ability of laboratory animals using a climbing ladder according to claim 1, wherein the hemispherical transparent cover comprises a material including but not limited to plastic and glass.
4. The device for testing the analytical capability of the experimental animal by using the climbing ladder according to claim 1, wherein the direction of the experimental animal inlet and outlet of the hemispherical transparent cover can be arbitrarily adjusted, and the direction of the experimental animal inlet and outlet of the hemispherical transparent cover faces away from the transparent container with the experimental animal inlet and outlet when the analytical capability is tested.
5. A device for testing the analytical ability of laboratory animals by means of climbing ladders according to claim 1, characterized in that the height differences do not affect the visual access of the laboratory animals to the objects in the hemispherical transparent cover.
6. A device for testing the analytical ability of laboratory animals by means of climbing ladders according to claim 1, characterized in that the attractants are items of different colour, shape, smell, sound and light.
7. An apparatus for testing the analytical ability of a laboratory animal using a climbing ladder according to claim 1, wherein the time is used as a measure for determining the analytical ability of the laboratory animal.
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| CN114342816A CN114342816A (en) | 2022-04-15 |
| CN114342816B true CN114342816B (en) | 2023-04-25 |
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| US5117780A (en) * | 1991-04-01 | 1992-06-02 | Wooten Richard R | Combined portable animal waste and training device |
| JP2004532475A (en) * | 2001-05-15 | 2004-10-21 | サイコジェニックス・インコーポレーテッド | Systems and methods for monitoring behavioral information engineering |
| CN202551866U (en) * | 2012-04-16 | 2012-11-28 | 刘宝密 | Automatic detector for animal vitality |
| CN210811068U (en) * | 2019-08-09 | 2020-06-23 | 上海中医药大学附属岳阳中西医结合医院 | Improved animal catwalk gait analysis system target box |
| CN111742852B (en) * | 2020-06-18 | 2022-02-25 | 九江学院 | Rat cognitive behavior comprehensive test method |
| CN112106673A (en) * | 2020-09-11 | 2020-12-22 | 北京希诺谷生物科技有限公司 | Feeding cage device and dog movement capacity evaluation method |
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