CN114259456A - Fullerene moisturizing anti-aging moisturizing water and preparation method thereof - Google Patents

Fullerene moisturizing anti-aging moisturizing water and preparation method thereof Download PDF

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CN114259456A
CN114259456A CN202111583085.7A CN202111583085A CN114259456A CN 114259456 A CN114259456 A CN 114259456A CN 202111583085 A CN202111583085 A CN 202111583085A CN 114259456 A CN114259456 A CN 114259456A
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moisturizing
fullerene
parts
aging
water
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钱德玉
张洪莲
刘建新
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Guangzhou Renault Biotechnology Co ltd
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Guangzhou Renault Biotechnology Co ltd
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Abstract

The invention belongs to the technical field of cosmetics, and particularly discloses a fullerene moisturizing anti-aging moisturizing nutrient solution and a preparation method thereof, wherein the fullerene moisturizing anti-aging moisturizing nutrient solution is prepared from the following raw materials: essence, chelating agent, pH regulator, thickener, luba oil, L-fucose, antiseptic, erythritol, fullerene, aloe vera gel, humectant, plant extract, polyalcohol and deionized water. According to the formula system, the erythritol can promote the penetration of active ingredients and the absorption of the active ingredients by skin on the premise of having a certain moisturizing effect, can promote the improvement of moisturizing and water locking capabilities, is formed internally and externally, and can promote the skin moisturizing barrier.

Description

Fullerene moisturizing anti-aging moisturizing water and preparation method thereof
Technical Field
The invention relates to the technical field of cosmetics, in particular to fullerene moisturizing, anti-aging and moisturizing lotion and a preparation method thereof.
Background
With the rapid development of nanotechnology, nanomaterials have become a new material. The nano material has unique physical and chemical properties, such as small-size effect, huge specific surface area, extremely high reactivity, quantum effect and the like, and the characteristics enable the nano science to become one of three major supporting sciences in the world.
Fullerene, as the first symmetric nanostructure in the family of carbon nanomaterials, has attracted considerable attention in the field of nanomaterials. The fullerene has multiple biological effects such as antioxidant activity, antibacterial activity, photodynamic activity, cell protection and the like, and has a huge application prospect in the field of cosmetics.
Disclosure of Invention
The invention provides fullerene moisturizing and anti-aging moisturizing nutrient solution and a preparation method thereof.
The invention adopts the following technical scheme for solving the technical problems:
the fullerene moisturizing, anti-aging and moistening nutrient water is prepared from the following raw materials in parts by weight: 0.02-0.08 part of essence, 0.05-0.12 part of chelating agent, 0.08-0.28 part of pH regulator, 0.1-0.55 part of thickening agent, 0.2-0.6 part of luba oil, 0.1-0.5 part of L-fucose, 0.2-0.6 part of preservative, 0.2-0.8 part of erythritol, 0.1-1 part of fullerene, 0.3-1.5 parts of aloe vera gel, 1.5-3 parts of humectant, 2-7 parts of plant extract, 6-15 parts of polyhydric alcohol and 60-80 parts of deionized water.
The inventor of the invention finds in a large number of researches that in the formula system, the erythritol can promote the penetration of active ingredients, promote the absorption of the active ingredients by skin, promote the moisture retention and water locking capacity of the skin, form an internal and external skin moisture barrier, the fullerene can effectively remove free radicals, brighten skin color, weaken fine lines, recover and activate the self activity of the body, promote the synthesis of collagen, promote the regeneration of skin cells, rejuvenate the skin and improve the water content of the skin, and the L-fucose has a certain moisture retention effect, can repair damaged collagen connective tissues, promote the normal metabolism of the collagen, recover the synthesis function of the collagen, promote the proliferation of skin cells and the young state, thereby improving the water content of the skin.
The fullerene, the erythritol and the L-fucose have obvious synergistic effect on the aspects of water replenishing and moisturizing, and can promote skin metabolism, skin rejuvenation and skin moisture content increase from multiple dimensions. If one of erythritol, L-fucose or fullerene is reduced, the moisturizing effect is obviously reduced, and the good moisturizing effect can be achieved only by combining the erythritol, the L-fucose and the fullerene.
As a preferable scheme, the fullerene moisturizing and anti-aging nourishing water is prepared from the following raw materials in parts by weight: 0.04-0.08 part of essence, 0.08-0.12 part of chelating agent, 0.1-0.2 part of pH regulator, 0.2-0.4 part of thickening agent, 0.2-0.5 part of luba oil, 0.2-0.5 part of L-fucose, 0.3-0.6 part of preservative, 0.4-0.7 part of erythritol, 0.2-1 part of fullerene, 0.3-1.2 parts of aloe vera gel, 1.8-3 parts of humectant, 4-7 parts of plant extract, 10-15 parts of polyhydric alcohol and 65-80 parts of deionized water.
As a preferable scheme, the fullerene moisturizing and anti-aging nourishing water is prepared from the following raw materials in parts by weight: 0.05 part of essence, 0.11 part of chelating agent, 0.15 part of pH regulator, 0.35 part of thickening agent, 0.4 part of luba oil, 0.4 part of L-fucose, 0.5 part of preservative, 0.6 part of erythritol, 0.8 part of fullerene, 1 part of aloe vera gel, 2.35 parts of humectant, 5 parts of plant extract, 14 parts of polyhydric alcohol and 74.29 parts of deionized water.
Preferably, the chelating agent is disodium edetate.
Preferably, the pH regulator is arginine or triethanolamine.
As a preferable scheme, the preservative is prepared from phenoxyethanol, 1, 2-glycol and chlorphenesin in a weight ratio of 1: 0.2-1: 0.1 to 0.5.
Preferably, the humectant is prepared from D-panthenol, methyl glucitol polyether-20, sodium hyaluronate and bioglycan-1 in a weight ratio of 1-5: 2-10: 1-4: 2 to 12.
By adopting the humectant, the humectant is used as the basic humectant component of the invention, and under the action of the humectant component, the fullerene, the erythritol and the L-fucose play good roles.
As a preferred scheme, the plant extract is prepared from coffee extract, centella asiatica extract, oat extract, water lily flower extract, lilium candidum extract and spirulina extract according to the weight ratio of 1: 0.5-2: 1-5: 1-5: 1-10: 1 to 5.
The plant extract is taken as an effective component, and can achieve good effects of moisturizing, resisting inflammation, repairing and resisting oxidation.
Preferably, the polyhydric alcohol is one or more of glycerol, 1, 3-butanediol, 1, 2-pentanediol, 1, 2-hexanediol, polypropylene glycol and sorbitol.
The invention also provides a preparation method of the fullerene moisturizing and anti-aging nourishing water, which is used for preparing the fullerene moisturizing and anti-aging nourishing water and comprises the following steps:
s1, adding the chelating agent, the thickening agent, the polyhydric alcohol and the humectant into deionized water, heating to 80-90 ℃, and uniformly stirring;
s2, cooling to 40-50 ℃, adding essence, pH regulator, lubas oil, L-fucose, preservative, erythritol, fullerene, aloe vera gel and plant extract, and uniformly stirring to obtain the fullerene moisturizing and anti-aging nourishing water.
The invention has the beneficial effects that: the fullerene moisturizing, anti-aging and nourishing water has good moisturizing and moisturizing effects and simultaneously has good anti-aging effects, in the formula system, the erythritol can promote the penetration of active ingredients and the absorption of the active ingredients by the skin on the premise of having a certain moisturizing effect, can promote the improvement of moisturizing and water-locking capabilities, can promote the formation of internal and external skin moisturizing barriers, the fullerene can effectively remove free radicals, brighten the skin color, fade fine lines, recover and activate the body vitality, promote the synthesis of collagen, promote the regeneration of skin cells, rejuvenate the skin and improve the skin water content, the L-fucose has a certain moisturizing effect and can repair damaged collagen connective tissues, promote the normal metabolism of collagen, recover the synthesis function of collagen and promote the skin cell proliferation, young state, thereby increasing skin moisture content.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the present invention, the parts are all parts by weight unless otherwise specified.
Example 1
The fullerene moisturizing, anti-aging and moistening nutrient water is prepared from the following raw materials in parts by weight: 0.05 part of essence, 0.11 part of chelating agent, 0.15 part of pH regulator, 0.35 part of thickening agent, 0.4 part of luba oil, 0.4 part of L-fucose, 0.5 part of preservative, 0.6 part of erythritol, 0.8 part of fullerene, 1 part of aloe vera gel, 2.35 parts of humectant, 5 parts of plant extract, 14 parts of polyhydric alcohol and 74.29 parts of deionized water.
The chelating agent is disodium ethylene diamine tetraacetate.
The pH regulator is arginine.
The preservative is prepared from phenoxyethanol, 1, 2-glycol and chlorphenesin in a weight ratio of 1: 0.8: 0.2.
The humectant is prepared from D-panthenol, methyl glucitol polyether-20, sodium hyaluronate and biological carbohydrate gum-1 in a weight ratio of 3: 8: 2: 7.
The plant extract is prepared from coffee extract, centella extract, oat extract, water lily flower extract, lilium brownii flower extract and spirulina extract according to a weight ratio of 1: 1: 4: 4: 6: 3, and (3).
The polyhydric alcohol is prepared from glycerol, 1, 3-butanediol, 1, 2-pentanediol, 1, 2-hexanediol and a solvent prepared from the following components in a weight ratio of 1: 1: 0.2: 0.3.
The preparation method of the fullerene moisturizing and anti-aging nourishing water comprises the following steps:
s1, adding the chelating agent, the thickening agent, the polyhydric alcohol and the humectant into deionized water, heating to 85 ℃, and uniformly stirring;
s2, cooling to 45 ℃, adding essence, pH regulator, lubas oil, L-fucose, preservative, erythritol, fullerene, aloe vera gel and plant extract, and uniformly stirring to obtain the fullerene moisturizing and anti-aging nourishing water.
Example 2
The fullerene moisturizing, anti-aging and moistening nutrient water is prepared from the following raw materials in parts by weight: 0.02 part of essence, 0.12 part of chelating agent, 0.15 part of pH regulator, 0.3 part of thickening agent, 0.2 part of luba oil, 0.5 part of L-fucose, 0.6 part of preservative, 0.2 part of erythritol, 0.4 part of fullerene, 0.3 part of aloe vera gel, 3 parts of humectant, 2 parts of plant extract, 15 parts of polyhydric alcohol and 77.21 parts of deionized water.
The chelating agent is disodium ethylene diamine tetraacetate.
The pH regulator is arginine.
The preservative is prepared from phenoxyethanol, 1, 2-glycol and chlorphenesin in a weight ratio of 1: 0.2: 0.5.
The humectant is prepared from D-panthenol, methyl glucitol polyether-20, sodium hyaluronate and biological carbohydrate gum-1 in a weight ratio of 1: 10: 1: 12.
The plant extract is prepared from coffee extract, centella extract, oat extract, water lily flower extract, lilium brownii flower extract and spirulina extract according to a weight ratio of 1: 2: 1: 1: 10: 1.
The polyhydric alcohol is prepared from glycerol, 1, 3-butanediol, 1, 2-pentanediol, 1, 2-hexanediol and a solvent prepared from the following components in a weight ratio of 1: 1: 0.2: 0.3.
The preparation method of the fullerene moisturizing and anti-aging nourishing water comprises the following steps:
s1, adding the chelating agent, the thickening agent, the polyhydric alcohol and the humectant into deionized water, heating to 85 ℃, and uniformly stirring;
s2, cooling to 45 ℃, adding essence, pH regulator, lubas oil, L-fucose, preservative, erythritol, fullerene, aloe vera gel and plant extract, and uniformly stirring to obtain the fullerene moisturizing and anti-aging nourishing water.
Example 3
The fullerene moisturizing, anti-aging and moistening nutrient water is prepared from the following raw materials in parts by weight: 0.08 part of essence, 0.05 part of chelating agent, 0.2 part of pH regulator, 0.4 part of thickening agent, 0.6 part of luba oil, 0.1 part of L-fucose, 0.2 part of preservative, 0.8 part of erythritol, 0.5 part of fullerene, 1.5 parts of aloe vera gel, 1.5 parts of humectant, 7 parts of plant extract, 10 parts of polyhydric alcohol and 77.07 parts of deionized water.
The chelating agent is disodium ethylene diamine tetraacetate.
The pH regulator is arginine.
The preservative is prepared from phenoxyethanol, 1, 2-glycol and chlorphenesin in a weight ratio of 1: 1: 0.1.
The humectant is prepared from D-panthenol, methyl glucitol polyether-20, sodium hyaluronate and biological carbohydrate gum-1 in a weight ratio of 5: 2: 4: 2.
The plant extract is prepared from coffee extract, centella extract, oat extract, water lily flower extract, lilium brownii flower extract and spirulina extract according to a weight ratio of 1: 0.5: 5: 5: 1: 5.
The polyhydric alcohol is prepared from glycerol, 1, 3-butanediol, 1, 2-pentanediol, 1, 2-hexanediol and a solvent prepared from the following components in a weight ratio of 1: 1: 0.2: 0.3.
The preparation method of the fullerene moisturizing and anti-aging nourishing water comprises the following steps:
s1, adding the chelating agent, the thickening agent, the polyhydric alcohol and the humectant into deionized water, heating to 85 ℃, and uniformly stirring;
s2, cooling to 45 ℃, adding essence, pH regulator, lubas oil, L-fucose, preservative, erythritol, fullerene, aloe vera gel and plant extract, and uniformly stirring to obtain the fullerene moisturizing and anti-aging nourishing water.
Example 4
The fullerene moisturizing, anti-aging and moistening nutrient water is prepared from the following raw materials in parts by weight: 0.06 part of essence, 0.1 part of chelating agent, 0.18 part of pH regulator, 0.38 part of thickening agent, 0.4 part of luba oil, 0.35 part of L-fucose, 0.4 part of preservative, 0.4 part of erythritol, 0.6 part of fullerene, 0.8 part of aloe vera gel, 2.4 parts of humectant, 5 parts of plant extract, 12 parts of polyhydric alcohol and 76.93 parts of deionized water.
The chelating agent is disodium ethylene diamine tetraacetate.
The pH regulator is arginine.
The preservative is prepared from phenoxyethanol, 1, 2-glycol and chlorphenesin in a weight ratio of 1: 0.5: 0.3.
The humectant is prepared from D-panthenol, methyl glucitol polyether-20, sodium hyaluronate and biological carbohydrate gum-1 in a weight ratio of 2: 8: 4: 6.
The plant extract is prepared from coffee extract, centella extract, oat extract, water lily flower extract, lilium brownii flower extract and spirulina extract according to a weight ratio of 1: 1: 3: 4: 6: 2.
The polyhydric alcohol is prepared from glycerol, 1, 3-butanediol, 1, 2-pentanediol, 1, 2-hexanediol and a solvent prepared from the following components in a weight ratio of 1: 1: 0.2: 0.3.
The preparation method of the fullerene moisturizing and anti-aging nourishing water comprises the following steps:
s1, adding the chelating agent, the thickening agent, the polyhydric alcohol and the humectant into deionized water, heating to 85 ℃, and uniformly stirring;
s2, cooling to 45 ℃, adding essence, pH regulator, lubas oil, L-fucose, preservative, erythritol, fullerene, aloe vera gel and plant extract, and uniformly stirring to obtain the fullerene moisturizing and anti-aging nourishing water.
Comparative example 1
Comparative example 1 differs from example 1 in that comparative example 1 does not contain the L-fucose and the L-fucose is replaced with an equal amount of erythritol and fullerene, all else being equal.
The fullerene moisturizing, anti-aging and moistening nutrient water is prepared from the following raw materials in parts by weight: 0.05 part of essence, 0.11 part of chelating agent, 0.15 part of pH regulator, 0.35 part of thickening agent, 0.4 part of luba oil, 0.5 part of preservative, 0.8 (0.6 + 0.2) part of erythritol, 1 (0.8 + 0.2) part of fullerene, 1 part of aloe vera gel, 2.35 parts of humectant, 5 parts of plant extract, 14 parts of polyhydric alcohol and 74.29 parts of deionized water.
Comparative example 2
Comparative example 2 differs from example 1 in that comparative example 2 does not contain the fullerene, the fullerene is replaced with an equal amount of erythritol and L-fucose, and the other things are the same.
The fullerene moisturizing, anti-aging and moistening nutrient water is prepared from the following raw materials in parts by weight: 0.05 part of essence, 0.11 part of chelating agent, 0.15 part of pH regulator, 0.35 part of thickening agent, 0.4 part of luba oil, 0.8 (0.4 + 0.4) part of L-fucose, 0.5 part of preservative, 1 (0.6 + 0.4) part of erythritol, 1 part of aloe vera gel, 2.35 parts of humectant, 5 parts of plant extract, 14 parts of polyhydric alcohol and 74.29 parts of deionized water.
Comparative example 3
Comparative example 3 differs from example 1 in that comparative example 3 does not contain the erythritol and the erythritol is replaced with an equal amount of L-fucose, fullerene, all else being equal.
The fullerene moisturizing, anti-aging and moistening nutrient water is prepared from the following raw materials in parts by weight: 0.05 part of essence, 0.11 part of chelating agent, 0.15 part of pH regulator, 0.35 part of thickening agent, 0.4 part of luba oil, 0.5 part of preservative, 0.8 (0.6 + 0.2) part of erythritol, 1 (0.8 + 0.2) part of fullerene, 1 part of aloe vera gel, 2.35 parts of humectant, 5 parts of plant extract, 14 parts of polyhydric alcohol and 74.29 parts of deionized water.
To further demonstrate the effect of the present invention, the following test methods were provided:
1. selecting 35 testers, wherein the testers are 22-25 years old, female in gender and randomly divided into 7 groups, 5 testers in each group respectively try out the fullerene moisturizing and anti-aging nourishing water prepared in the examples 1-4 and the comparative examples 1-3, after the testers clean the face, the fullerene moisturizing and anti-aging nourishing water is tried out, the using amount is 3.8-4.2 g, and the skin moisture content before use, after use (immediate effect) and 2 hours after use is respectively tested, wherein the skin moisture content is tested by a skin moisture tester, and the test results are shown in table 1.
Table 1 skin moisture test results
Figure 266262DEST_PATH_IMAGE001
As can be seen from the table 1, the fullerene moisturizing and anti-aging nourishing water has good moisturizing and moisturizing effects and can significantly improve the moisture content of skin.
Compared with the examples 1 to 4, it can be known that different raw material ratios can affect the moisturizing and water replenishing effects of the fullerene moisturizing and anti-aging nourishing water, wherein the example 1 is the best implementation mode and has the best moisturizing and water replenishing effects.
Compared with the comparative examples 1 and 1-3, the erythritol, the L-fucose and the fullerene have a remarkable synergistic effect in the aspects of water replenishing and moisturizing, in the formula system, if one of the erythritol, the L-fucose and the fullerene is less, the water replenishing and moisturizing effect is remarkably reduced, and the good water replenishing and moisturizing effect can be achieved only by combining the erythritol, the L-fucose and the fullerene.
In light of the foregoing description of preferred embodiments according to the invention, it is clear that many changes and modifications can be made by the person skilled in the art without departing from the scope of the invention. The technical scope of the present invention is not limited to the contents of the specification, and must be determined according to the scope of the claims.

Claims (10)

1. The fullerene moisturizing, anti-aging and moisturizing nutrient solution is characterized by being prepared from the following raw materials in parts by weight: 0.02-0.08 part of essence, 0.05-0.12 part of chelating agent, 0.08-0.28 part of pH regulator, 0.1-0.55 part of thickening agent, 0.2-0.6 part of luba oil, 0.1-0.5 part of L-fucose, 0.2-0.6 part of preservative, 0.2-0.8 part of erythritol, 0.1-1 part of fullerene, 0.3-1.5 parts of aloe vera gel, 1.5-3 parts of humectant, 2-7 parts of plant extract, 6-15 parts of polyhydric alcohol and 60-80 parts of deionized water.
2. The fullerene moisturizing, anti-aging and moistening nutrient water as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 0.04-0.08 part of essence, 0.08-0.12 part of chelating agent, 0.1-0.2 part of pH regulator, 0.2-0.4 part of thickening agent, 0.2-0.5 part of luba oil, 0.2-0.5 part of L-fucose, 0.3-0.6 part of preservative, 0.4-0.7 part of erythritol, 0.2-1 part of fullerene, 0.3-1.2 parts of aloe vera gel, 1.8-3 parts of humectant, 4-7 parts of plant extract, 10-15 parts of polyhydric alcohol and 65-80 parts of deionized water.
3. The fullerene moisturizing, anti-aging and moistening nutrient water as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 0.05 part of essence, 0.11 part of chelating agent, 0.15 part of pH regulator, 0.35 part of thickening agent, 0.4 part of luba oil, 0.4 part of L-fucose, 0.5 part of preservative, 0.6 part of erythritol, 0.8 part of fullerene, 1 part of aloe vera gel, 2.35 parts of humectant, 5 parts of plant extract, 14 parts of polyhydric alcohol and 74.29 parts of deionized water.
4. The fullerene moisturizing anti-aging moisturizing water as claimed in claim 1, wherein the chelating agent is disodium ethylenediaminetetraacetate.
5. The fullerene moisturizing anti-aging moisturizing water as claimed in claim 1, wherein the pH regulator is arginine or triethanolamine.
6. The fullerene moisturizing, anti-aging and nourishing water as claimed in claim 1, wherein the preservative is prepared from phenoxyethanol, 1, 2-glycol and chlorphenesin in a weight ratio of 1: 0.2-1: 0.1 to 0.5.
7. The fullerene moisturizing, anti-aging and nourishing water as claimed in claim 1, wherein the moisturizing agent is prepared from D-panthenol, methyl glucitol polyether-20, sodium hyaluronate and biogum glycocoll-1 in a weight ratio of 1-5: 2-10: 1-4: 2 to 12.
8. The fullerene moisturizing and anti-aging moisturizing and nourishing water as claimed in claim 1, wherein the plant extract is prepared from coffee extract, centella asiatica extract, oat extract, water lily flower extract, lilium candidum extract and spirulina extract according to a weight ratio of 1: 0.5-2: 1-5: 1-5: 1-10: 1 to 5.
9. The fullerene moisturizing, anti-aging and nourishing water as claimed in claim 1, wherein the polyhydric alcohol is one or more of glycerol, 1, 3-butanediol, 1, 2-pentanediol, 1, 2-hexanediol, polypropylene glycol and sorbitol.
10. A preparation method of fullerene moisturizing and anti-aging nourishing water, which is used for preparing the fullerene moisturizing and anti-aging nourishing water as claimed in any one of claims 1 to 9, and comprises the following steps:
s1, adding the chelating agent, the thickening agent, the polyhydric alcohol and the humectant into deionized water, heating to 80-90 ℃, and uniformly stirring;
s2, cooling to 40-50 ℃, adding essence, pH regulator, lubas oil, L-fucose, preservative, erythritol, fullerene, aloe vera gel and plant extract, and uniformly stirring to obtain the fullerene moisturizing and anti-aging nourishing water.
CN202111583085.7A 2021-12-22 2021-12-22 Fullerene moisturizing anti-aging moisturizing water and preparation method thereof Pending CN114259456A (en)

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN117860640A (en) * 2024-01-15 2024-04-12 佛山市思怡诺生物科技有限公司 A skin external composition and its preparation method

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WO2018180009A1 (en) * 2017-03-30 2018-10-04 ビタミンC60バイオリサーチ株式会社 Fullerene-containing cosmetic composition
CN113520888A (en) * 2021-07-15 2021-10-22 广东雷诺化妆品研究院有限公司 Anti-aging composition containing fullerene and preparation method and application thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106109294A (en) * 2016-06-29 2016-11-16 广州市巧美化妆品有限公司 A kind of moisturizing essence and preparation method thereof
WO2018180009A1 (en) * 2017-03-30 2018-10-04 ビタミンC60バイオリサーチ株式会社 Fullerene-containing cosmetic composition
CN113520888A (en) * 2021-07-15 2021-10-22 广东雷诺化妆品研究院有限公司 Anti-aging composition containing fullerene and preparation method and application thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117860640A (en) * 2024-01-15 2024-04-12 佛山市思怡诺生物科技有限公司 A skin external composition and its preparation method
CN117860640B (en) * 2024-01-15 2024-07-05 佛山市思怡诺生物科技有限公司 A skin external composition and its preparation method

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