CN114229240B

CN114229240B - Sample storage and transportation device, sampling storage and transportation integrated device and training device

Info

Publication number: CN114229240B
Application number: CN202111249014.3A
Authority: CN
Inventors: 杨惠; 毛萌
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-10-26
Filing date: 2021-10-26
Publication date: 2023-01-10
Anticipated expiration: 2041-10-26
Also published as: CN114229240A

Abstract

The invention belongs to the technical field of biological sample storage and transportation, relates to a living body storage and transportation technology of biological samples, and particularly relates to a sample storage and transportation device, a sampling storage and transportation integrated device and a special use training device designed for improving the self-sampling success rate. The sample storage and transportation device comprises a first cavity body, a second cavity body and a third cavity body, wherein the first cavity body is provided with a storage space for containing a sample and an open first port; the first end cover can be used for plugging the first port; wherein the first port may be used for placing and/or removing a sample. The sampling, storing and transporting integrated device comprises a first cavity body, a second cavity body and a third cavity body, wherein the first cavity body is a tubular pipe L with an open proximal end and an open distal end; a first end cap; a check valve body; comprises a handle having a proximal handle end and a distal handle end; the sampling brush bundle is provided with bristles and a bristle seat, and the bristles are fixed on the bristle seat and are in a bundle shape; any user can operate the sample to adapt to the requirement of long-time long-distance transportation, and the consistency of the sample and the objective fact of the detected object is improved.

Description

Sample storage and transportation device, sampling storage and transportation integrated device and training device

Technical Field

The invention belongs to the technical field of biological sample storage and transportation, relates to a living body storage and transportation technology of biological samples, and particularly relates to a sample storage and transportation device, a sampling storage and transportation integrated device and a special use training device designed for improving the self-sampling success rate.

Background

HPV (human papilloma virus) is a papillomavirus A genus belonging to the family papovaviridae, is a spherical DNA virus and causes the squamous epithelial proliferation of the human skin mucosa. Currently more than 130 have been isolated, with different types causing different clinical manifestations. The tissue invasion can be classified into the following types according to different tissue sites: (1) low risk type of skin: including HPV1, 2, 3, 4, 7, 10, 12, 15, etc., associated with common warts, flat warts, plantar warts, etc.; (2) high risk type of skin: including HPV5,8, 14, 17,20,36,38, are associated with epidermodysplasia verruciformis, and other malignancies that may also be associated with HPV infection include: vulvar, penile, anal, prostate, bladder cancer; (3) Mucosal low risk types such as HPV-6, 11, 13, 32, 34, 40, 42, 43, 44, 54, etc. and infected genital, anal, oropharyngeal, and esophageal mucosa; (4) Mucosa high-risk HPV-16, 18, 30, 31, 33, 35, 53 and 39 and cervical cancer, rectal cancer, oral cancer, tonsil cancer and the like.

Studies have shown that the probability of HPV infection in women during their lifetime is as high as 80%.

Persistent infection with high-risk HPV is a major factor in the development of cervical cancer. More than 90% of cervical cancers are accompanied by high-risk HPV infection. Enhanced screening for early detection of HPV infection is considered one of the currently effective cervical cancer prevention and treatment tools.

However, the HPV detection method is highly specialized. For example, in the sampling aspect, the sampling position, the sampling amount and the sampling method all have corresponding requirements, and improper operation may cause sampling omission, and further cause missed detection. Furthermore, the real-world situation is that current detection of a serious lack of professional resources. The technical personnel are limited and have regional centralization, and usually the personnel with prominent technical skills are concentrated in larger cities.

In summary, if the HPV is to be screened and detected in an early stage from a social macro level, the key problems faced are not the detection, diagnosis and treatment logics of individual medical cases, but the problems of how to achieve overall coverage/wide coverage of regions and groups, how to mobilize the public to actively participate, and the like. The applicant analyzes and considers that the prior art can effectively detect various HPV viruses in a sample, but the accuracy of individual sample acquisition, the coverage of the specialty on regions and groups and the subjective participation willingness of the object to be detected are important problems.

In the prior art, a detection mechanism provides sampling teaching and a sampling device to encourage self-sampling of an object to be detected and provides a solution for realizing wide coverage by means of logistics. However, the sample collection process which originally needs a professional to ensure the effectiveness and the biological change of the sample caused by long-term and long-distance transportation of the sample become important factors for the difference between the detection result and the objective fact of the detected object.

Disclosure of Invention

In order to solve the problem that objective facts of a sample to be detected and a detected object are different in the sample collection and transportation process, the following technical scheme can be adopted according to the idea of the invention, and specifically the following technical scheme is adopted:

the sample storage and transportation device is characterized by comprising,

a first cavity having a storage space for accommodating a sample and an open first port;

a first end cap operable to seal the first port;

wherein the first port may be used for placing and/or removing a sample.

One of the alternatives of the sample storage and transportation device is characterized by comprising,

a second cavity having a storage space containing a sample-holding agent and a sample-holding agent release port;

wherein the sample retention agent is operable to extend the effective retention time of the sample;

wherein the release port can release the sample-retaining agent toward the first cavity.

the one-way valve body has the function of discharging gas from the inside of the first cavity to the outside of the cavity in a one-way mode.

One of the alternatives for the sample storage and transport device is that the second chamber comprises,

and the holding agent air bag is used for storing the gaseous holding agent.

One of the alternatives for the sample storage and transport device is that the second cavity is disposed within the first end cap.

One of the alternatives of the sample storage and transportation device, wherein the first end cap comprises,

and a release control member having a control portion on which the release port is openable by an external force.

a holding agent display member having a first display portion for displaying a holding agent of a predetermined concentration;

wherein the first display portion has a first retentive agent state and a second retentive agent state that are distinguishable;

when the concentration of the retention agent in the first cavity is higher than the concentration threshold, the first display part displays a first retention agent state;

when the concentration of the maintainer in the first cavity is not higher than the concentration threshold, the first display part displays a second maintainer state.

One of the alternatives for the sample handling apparatus is characterized by comprising,

a sample display member having a second display portion for displaying a sample having a predetermined concentration;

wherein the first display portion has a first sample state and a second sample state that are distinguishable;

when the concentration of the sample in the first cavity is higher than the concentration threshold, the second display part displays a first sample state;

and when the concentration of the sample in the first cavity is not higher than the concentration threshold, the second display part displays a second sample state.

and an imaging surface in which the first display unit and the second display unit are visible in a direction facing the imaging surface.

One of the alternatives of the sample storage and transportation device is characterized in that the storage and transportation device is provided with,

the storage and transportation device can be freely placed on a background plane and is stabilized in a shooting attitude;

wherein, under the shooting posture, the shooting surface is parallel to the background plane and faces outwards.

One of the alternatives of the sample storage and transportation device, characterized in that,

the sample containment device is tubular with an open proximal end and an open distal end;

wherein the first end cap is arranged at the far end;

wherein, the check valve body is arranged at the near end.

the sample storage and transportation device is in a circular tube shape;

when the axis of the round pipe is parallel to the background plane and is placed on the horizontal background plane, the gravity center of the storage and transportation device has the tendency of acting on the storage and transportation device and keeping the storage and transportation device in the shooting posture.

a pseudo-intervention section having an intervention region;

wherein the intervening region may form visible differential information;

wherein the dummy insertion portion is visible in a direction facing the imaging surface.

One of the alternatives of the sample storage and transportation device is characterized in that,

the intervention area of the fake intervention part is a graffiti-able area;

wherein the visual difference information is free graffiti information.

and an intervention locking part which can cover the intervention area and lock.

A sampling, storing and transporting integrated device comprises,

in the sample storage and transportation device according to any of the above,

a first lumen being a tubular tube L having an open proximal end and an open distal end;

a first end cap;

a check valve body;

which is characterized by comprising the following steps of,

a handle having a proximal handle end and a distal handle end;

the sampling brush bundle is provided with bristles and a bristle seat, and the bristles are fixed on the bristle seat and are in a bundle shape;

the handle and the sampling brush bundle are arranged in the tube L;

wherein, the sampling brush bundle is close to the far end of the tube L, and the near end of the handle is close to the near end of the tube L;

wherein the handle has a degree of freedom of reciprocating motion in the tube L along the axial direction of the tube L, and the sampling position can be extended towards the far end of the tube and the introduction position can be retracted towards the near end of the tube;

wherein, when the handle extends to the sampling position, the sampling brush bundle is positioned outside the tube L and near the far end of the tube.

One of the alternatives of the sampling, storage and transportation integrated device is characterized by comprising,

the rubber sleeve is arranged at the end part of the near end of the tube L or on the inner wall of the tube L close to the near end;

the rubber plug is arranged on the handle, and when the handle retracts to the leading-in position, the rubber plug is in extrusion contact with the rubber sleeve to form the duckbilled one-way valve body.

a second cavity in the sample storage and transport device.

a retention agent display in the sample storage device.

the sample display member in the sample storage and transportation device.

the shooting surface in the sample storage and transportation device.

the shooting attitude in the sample storage and transportation device.

One of the alternatives of the sampling, storing and transporting integrated device is characterized by comprising,

the sample storage and transportation device is provided with a fake intervention part.

the sample storage and transportation device comprises an intervention locking part.

the brush bundle expanding component is provided with a first posture and a second posture, the brush bundle is in a bundle-shaped furling state under the first posture, and the brush bundle is in a blossom-shaped unfolding state under the second posture.

One of the alternatives of the sampling, storage and transportation integrated device is characterized in that the brush bundle expanding component comprises,

the attitude control component A is provided with a control end A1 arranged at the near end of the handle, a transmission part and an execution part.

One of the alternatives of the sampling, storing and transporting integrated device is characterized in that,

the executing part is provided with an air bag;

the transmission part is provided with an air passage;

the control end A1 is provided with a squeezing part;

the pressing part, the air channel and the air bag are connected to form an airtight space, and external force acts on the pressing part to enable the air bag to be changed from the first posture to the second posture.

One of the alternatives of the sampling, storage and transportation integrated device is characterized in that,

the air bag is provided with a recovery concave part, the recovery concave part is provided with prestress, and the prestress acts on the concave part to enable the concave part to have the tendency of maintaining the first posture;

and the restoring recessed portion is convertible from a recessed state to an expanded state by an increased air pressure from the inside of the airbag, and generates an outward thrust on the edge of the restoring recessed portion.

One of the alternatives of the sampling, storing and transporting integrated device is characterized by comprising

And the end cover lock catch can be used for locking the first end cover in a covering posture.

a handle thrust member having a thrust attitude and a free attitude;

when the first end cover is in a covered state, the handle thrust piece is in a thrust posture;

when the first end cover is in a non-covering state, the handle thrust piece is in a free posture;

the thrust attitude is provided with a limit bulge, and the limit bulge is used for limiting the handle to extend and move to the sampling position on the reciprocating motion degree of freedom;

the limiting bulge can be released in the free posture, and the limitation of the limiting bulge on the extension motion of the handle is relieved;

wherein, the handle extension motion is the motion of handle to sample position direction on the reciprocating motion degree of freedom.

One of the alternatives of the sampling, storage and transportation integrated device is characterized in that the end cover lock catch is a bidirectional elastic buckle and has an elastic threshold force F1;

when the external reverse acting force is larger than F1, the end cover lock catch can be released and unlocked.

One of the alternatives of the sampling, storage and transportation integrated device is characterized in that the end cover lock catch comprises,

a secondary latch having an unlocking force direction different from the external counter force.

One of the alternatives of the sampling, storage and transportation integrated device is characterized in that the secondary locking piece comprises a first locking piece,

and a rotation locking part which can rotate and unlock by applying unlocking force.

The sample storage and transportation training device is characterized by comprising,

in the sample storage and transportation device, a sample storage and transportation device,

a first cavity and a first end cap;

the control member is released.

One of the alternatives of the sample storage and transportation training device is characterized by comprising,

a holding agent analog display member having a first display light source and a first light source turn-on circuit;

the switch of the first light source starting circuit is connected with the release control part;

wherein, the holding agent simulation display piece is arranged at the corresponding position of the holding agent display piece in the sample storage and transportation device.

the sample simulation display piece is provided with a second display light source and a second light source starting circuit;

the switch of the second light source starting circuit is connected with the release control part;

the sample simulation display piece is arranged at the corresponding position of the sample display piece in the sample storage and transportation device.

the shooting surface.

the sample storage and transportation device comprises a fake intervention part.

The sampling, storage and transportation integrated training device is characterized by comprising,

in the sampling, storage and transportation integrated device,

a first cavity;

a first end cap;

a handle; and the combination of (a) and (b),

and the control end A1 in the sampling, storage and transportation integrated device.

One of the alternatives of the sampling, storage and transportation integrated training device is characterized by comprising,

and the end cover in the sampling, storing and transporting integrated device is locked.

One of the alternatives of the sampling, storing and transporting integrated training device is characterized by comprising,

the handle thrust piece in the sampling, storing and transporting integrated device.

and the second-stage locking piece is arranged in the sampling, storing and transporting integrated device.

the sampling, storing and transporting integrated device is provided with a rotating locking part.

The sample storage and transportation device has the advantages that the sample storage and transportation device can be operated by any user to enable the sample to meet the long-time long-distance transportation requirement, and the consistency of the sample and the objective fact of a detected object is improved. A solution is provided to address possible damage factors to the sample from the logistics transport. The provided shooting surface imitation scheme with the intervention of the detected object can solve the trust problem of whether the detected user detects the sample or not to the greatest extent, and further can improve the participation enthusiasm of the user. The training device provides preview training for users, can solve the psychological barrier of manual operation of most users, and can effectively improve the effects of sample acquisition accuracy, comprehensiveness and the like of user self-inspection.

Drawings

FIG. 1 is a schematic view of the connection of the handle, tube L and first end cap;

FIG. 2 is a schematic cross-sectional view of the tube L and the first end cap;

FIG. 3 is a schematic cross-sectional view of a tube L in a sampling state;

FIG. 4 is an enlarged schematic view at C of FIG. 3;

FIG. 5 is a perspective view of the position of FIG. 4;

FIG. 6 is a cross-sectional schematic view of the tube L and first end cap in a stored and shipped state;

FIG. 7 is an enlarged schematic view at D of FIG. 6;

FIG. 8 is an enlarged schematic view at E in FIG. 6;

FIG. 9 is a schematic view of a retainer balloon puncture;

FIG. 10 is an enlarged schematic view at F of FIG. 9;

FIG. 11 is a cross-sectional schematic view of the first end cap;

FIG. 12 is a schematic view of an interventional region;

FIG. 13 is a schematic view of a second display portion;

FIG. 14 is a cross-sectional view of the handle with the sampling brush bundle deployed;

FIG. 15 is a cross-sectional view of the handle with the sampling brush bundle collapsed;

FIG. 16 is a schematic drawing showing the sampling brush bundle expanded and contracted;

FIG. 17 is a schematic view of the first end cap connected to the tube L;

FIG. 18 is a schematic view of the rotation lock portion locking and unlocking process;

FIG. 19 is a schematic view of a first end cap connection process;

FIG. 20 is a schematic view of the handle thrust member contacting the stop lug.

Reference numerals are as follows:

the medical instrument comprises a first cavity 10, a first port 11, a second display part 12, an intervention area 13, a tube L, a proximal end 14, a distal end 15, a check valve body 16, a rubber sleeve 161 and a rubber plug 162;

a first end cover 20, a second cavity 21, a release port 22, a holding agent air bag 23, a release control member 24, a control part 25, a handle thrust piece 26, a bidirectional elastic buckle 27 and a rotation locking part 28;

handle 30, handle proximal end 31, handle distal end 32, sampling brush bundle 33, bristles 331, bristle holder 332, stop boss 34;

control end A1, pressing part 41, air channel 42 and air bag 43.

Detailed Description

For the purpose of facilitating an understanding of the concepts claimed herein, the following specific embodiments designed according to the concepts of the present invention are provided. It should be understood that the specific structures and techniques which are designed and illustrated in the following claims to illustrate the inventive concepts are not intended to limit the scope of the invention.

Example 1:

referring to fig. 1-13, a sample storage and transportation device is provided, including,

a first chamber 10 having a storage space for accommodating a sample and an open first port 11;

a first end cap 20 operable to block the first port 11;

wherein the first port 11 may be used for placing and/or removing a sample.

The first chamber 10 is designed according to the state of the sample and the amount of the sample to be stored. If the sample needs to be transported together with the sampling device (such as a sampling brush) during storage and transportation, the cavity can also be a cavity structure with the functions of accommodating the sample and the sampling device. And arranging an end cover for sealing the cavity after the sample is placed in the cavity. The seal is understood to be a broad seal provided according to the physicochemical characteristics of the sample, and is not necessarily a hermetic seal.

Example 2:

referring to fig. 2-3, and 6-11, one of the alternatives for the sample tote, including,

a second chamber 21 having a storage space for containing a sample-retaining agent and a sample-retaining agent release port 22;

wherein the release port 22 can release the sample-retaining agent toward the first chamber 10.

The second cavity 21 can be added with different sample holding agents according to the type of the sample, and the holding agents can be in various forms such as gas, liquid, atomized liquid, slow release agent and the like. The retaining agent is in a protected state prior to being released within the second cavity 21 and may be suitable for long term storage, transport. The release port 22 provided toward the first chamber 10 allows the addition of the sample-retaining agent in the first chamber 10 to be performed with a simple operation, without requiring professional knowledge, and can improve the effective time and transportability of the biological/living sample.

Example 3:

referring to fig. 2 and 9, one of the alternatives for the sample storage and transportation device, including,

the check valve body 16 has a function of discharging gas from the inside of the first chamber 10 to the outside thereof in a check manner.

According to the embodiment 2, the sufficient addition of the sample holding agent may be blocked by the air in the sealed first chamber 10, and the addition resistance is more significant particularly for the holding agent in a gaseous or atomized liquid state. The one-way valve body 16 is arranged in advance in the embodiment, so that the holding agent can be fully added in a state of no perception of an operator, and compared with various professional requirements (such as an upward or downward emptying method for gas addition) for adding the holding agent by professionals, a general subject without professional training is difficult to master the professional skills in one detection. The method has great significance for popularizing and using the technology by enabling the detected object without professional ability to realize the professional retention agent adding effect in a non-sensing state.

Example 4:

referring to fig. 8-11, one of the alternatives for the sample handling apparatus, the second chamber 21 comprises,

and a retention agent balloon 23 for storing a retention agent in a gaseous state.

The embodiment provides an air bag structure, and solves the storage problem of a gaseous retaining agent. The air bag can be an elastic shrinkable air bag generally, the air bag is expanded and forms shrinkage stress when the retention agent is filled, the retention agent is added only by puncturing or starting the air bag and depending on the shrinkage stress of the air bag.

Example 5:

referring to fig. 6-8, the second cavity 21 is disposed within the first end cap 20, which is one of the alternatives of the sample handling device.

The embodiment provides a specific arrangement scheme for the second cavity 21, and the second cavity 21 is arranged on the first end cap 20. The first end cap 20 has the advantages that design limitation on the first cavity 10 is not required, complete implementation of the function of the first cavity 10 is ensured, and the first end cap 20 can be manufactured independently and filled with the retention agent.

Example 6:

referring to fig. 10-11, one of the alternatives for the sample storage and transportation device, the first end cap 20 includes,

and a release control member 24 having a control portion 25, the release port 22 being openable by an external force acting on the control portion 25.

Taking the retention agent bladder 23 as an example, the release control member 24 may be a prick structure, and the control portion 25 may be a button, such as a lever button, that is pressed to move the prick structure or the retention agent bladder 23 relative to each other to pierce the bladder. For the user, the sample in the first cavity 10 can be packaged and stored only by putting the sample into the first cavity 10, covering the first end cap 20 and pressing the button.

Example 7:

one of the alternatives for the sample storage and transportation device, includes,

when the concentration of the retention agent in the first cavity 10 is higher than the concentration threshold, the first display part displays a first retention agent state;

wherein, when the concentration of the retention agent in the first cavity 10 is not higher than the concentration threshold, the first display part displays the second retention agent state.

The specific design scheme of the holding agent display member is set according to the characteristics of the holding agent in the prior art, such as color display, optical display and the like. The display of the retention agent can be used for evaluating the preservation condition of the sample, and if the state of the display of the retention agent is the second state of the retention agent, the possibility that the characteristic of the sample is changed can be reasonably suspected, and the probability that the detection result of the sample cannot reflect the objective fact of the detected object is increased. Furthermore, under business logic, there are conflicting parties in the interests between the object under examination and the detection mechanism. That is, in the extreme case of interest-driven, the testing institution will not test the sample according to the standard, or may not professionally examine the eligibility of the sample, which is one of the main reasons why the subject is not willing to participate in the test, because it will cause the subject to be in doubt about the test result. The maintainer display piece can provide a technical means, and the technical means is combined with the feedback of the detection mechanism to the sample, so that the detected object can know whether the sample obtained by the detection mechanism is an effective sample of the detected object, and the negative doubts of the detected object to the detection mechanism on one side can be objectively eliminated.

Example 8:

referring to fig. 13, one of the alternatives for the sample storage and transportation device, including,

a sample display member having a second display portion 12 for displaying a sample having a predetermined concentration;

when the concentration of the sample in the first cavity 10 is higher than the concentration threshold, the second display part 12 displays a first sample state;

when the concentration of the sample in the first cavity 10 is not higher than the concentration threshold, the second display portion 12 displays a second sample state.

Similar to the purpose of the retention agent display, the display is used for displaying the relation between the detected required concentration and the actual collected concentration of the sample. Another advantageous scenario of the sample display is to provide result feedback for the sample collection behavior of the object to be tested, so that the object to be tested can know whether the collection behavior meets the detection requirement. When the sample display is applied to the detection end, the function of the sample display part is the same as that of the holding agent display part, on one hand, the sample display part can be used for providing a professional judgment basis for a detection mechanism, on the other hand, the sample state of the detection mechanism applied to detection can be provided for the detected object through a certain feedback link, and the negative doubts of the detected object to the unilateral of the detection mechanism can be further objectively eliminated.

Example 9:

and an imaging surface in which the first display unit and the second display unit 12 are visible in a direction facing the imaging surface.

The photographing surface provides an effective solution for achieving specific purposes (such as the purpose of feedback of the detection mechanism to the subject) in the embodiments 7 and 8.

Example 10:

one of the alternatives for the sample handling apparatus,

the sample containment device is tubular with an open proximal end 14 and an open distal end 15;

wherein the first end cap 20 is disposed at the distal end 15;

wherein the check valve body 16 is disposed at the proximal end 14.

Example 11:

one of the alternatives for the sample storage and transportation device,

the sample storage and transportation device is in a circular tube shape;

when the axis of the circular tube is parallel to the background plane and is placed on the horizontal background plane, the gravity center of the storage and transportation device has a tendency of acting on the storage and transportation device and keeping the storage and transportation device in a shooting posture.

The design can improve the standard of shooting the shooting surface, realize quick standard shooting and provide the possibility of mass processing. In addition, the preparation of the shooting process can be improved, the shooting feedback efficiency is improved, and the method belongs to a key technology of large-scale and batch production.

Example 12:

a pseudo-intervention section having an intervention region 13;

wherein the intervening region 13 may form visible differential information;

wherein the dummy insertion portion is visible in a direction facing the imaging plane.

In the present embodiment, intervention mainly refers to autonomous intervention by any third party or subject, such as drawing, autonomously selecting a designated object, etc., and the result of the intervention cannot be predicted by a detection mechanism or other people. Due to autonomy and unpredictability of intervention, the technique can be used for sample tracking counterfeiting. One of the possible applications may prevent: after the sample of the detection mechanism or the intermediate link is lost or fails, the detection mechanism provides a detection result irrelevant to the sample, or the detection result is provided by dislocation after the sample is disordered.

Example 13:

referring to fig. 13, one of the alternatives for the sample storage and transportation device,

the intervention region 13 of the pseudo-intervention is a graffiti region;

wherein the visual difference information is free graffiti information.

The scrawling information has strong operability, does not need technical basic knowledge and has strong imitation.

Example 14:

an intervention locking part which can cover the intervention area 13 and lock.

The intervening locking portion may lock the intervening region 13, such as a transparent cover with a lock. The locking can prevent intervention information from being interfered by other objects, and the intervention information is protected.

Example 15:

referring to fig. 1-20, a sampling, storage and transportation integrated device includes,

in the sample storage and transportation apparatus according to any of the above,

a first lumen 10 being a tubular tube L having an open proximal end 14 and an open distal end 15;

a first end cap;

a check valve body 16;

which is characterized by comprising the following steps of,

a handle 30 having a proximal handle end 31 and a distal handle end 32;

a sampling brush bundle 33 having bristles 331 and a bristle holder 332, the bristles 331 being fixed to the bristle holder 332 in a bundle shape;

the handle 30 and the sampling brush bundle 33 are arranged in the tube L;

wherein the sampling brush bundle 33 is close to the distal end of the tube L, and the handle proximal end 31 is close to the proximal end of the tube L;

wherein the handle 30 has a degree of freedom of reciprocating movement in the tube L in the axial direction of the tube L, and extends to the distal end of the tube to a sampling position and retracts to the proximal end of the tube to an introduction position;

wherein, when the handle 30 is extended to the sampling position, the sampling brush bundle 33 is located outside the tube L near the distal end of the tube.

The embodiment provides a solution that storage and transportation device and sampling device combine, can accomplish the simple action and can realize the quick save to the sample of getting after sampling device finishes the sample. The method has obvious effect on collecting samples greatly influenced by air, simplifies the sampling operation steps for non-professionals, reduces the complexity, and has great significance on achieving the effect of wide coverage on the detection of self-sampling.

Example 16:

referring to fig. 2-7, one of the alternatives for sampling the unitary storage and transportation device, including,

the rubber sleeve 161 is arranged at the end part of the near end of the tube L or the inner wall of the tube L close to the near end;

the rubber plug 162 is disposed on the handle 30, and when the handle 30 is retracted to the guiding position, the rubber plug 162 contacts the rubber sleeve 161 in an extruding manner to form a duckbilled check valve.

The embodiment is based on the design of a sampling, storage and transportation integrated structure, and the requirement of the one-way valve of the storage and transportation device is met through a simple structure. In addition, the sampling operation process of the detected object is not sensed under the requirement, and the sealing and one-way valve structure of the storage and transportation device can be realized only by normally placing the sample after normal sampling.

Example 17:

one of the alternatives of the sampling, storage and transportation integrated device comprises a second cavity 21 in the sampling, storage and transportation integrated device.

Example 18:

one alternative of the sampling, storage and transportation integrated device comprises a retention agent display member in the sample storage and transportation device.

Example 19:

one of the alternatives of the sampling, storing and transporting integrated device comprises a sample display piece in the sample storing and transporting device.

Example 20:

one of the alternatives of the sampling, storing and transporting integrated device comprises a shooting surface in the sample storing and transporting device.

Example 21:

one of the alternatives of the sampling, storage and transportation integrated device comprises a shooting posture in the sample storage and transportation device.

Example 22:

one of the alternatives of the sampling, storing and transporting integrated device comprises a fake intervention part in the sampling, storing and transporting integrated device.

Example 23:

one of the alternatives of the sampling, storing and transporting integrated device comprises an intervention locking part in the sampling, storing and transporting integrated device.

Example 24:

referring to fig. 14-16, one of the alternatives for sampling the all-in-one storage and transportation device, including,

In the above embodiments, the main purpose of the tuft structure design of the bristles is: the sampling position of the device is in a cavity-like structure of the human body, such as uterus/body cavity. The cavity structure and depth, as well as safety indicators and risk control schemes, should be well known to the professional sampling personnel. However, even if the general self-tester informs the sampling requirement, the self-tester may insert too deeply due to the personal understanding deviation, the operation process tension, the misoperation and the like, and may cause the injury. Most of the existing sampling devices are of a structure that bristles are clamped by twisted iron wires, and the bristles of the structure are always in an unfolded state in the process of entering a body cavity to reach a target position (usually a cervical orifice), so that the body cavity wall of the non-target position is stimulated, non-target sampling objects can be brushed down, and the sampling result can be interfered; meanwhile, the foremost end of the sampling brush in the body cavity entering direction is the tail end of the twisted pair iron wire for fixing the brush hair, which belongs to a sharp hard object, and even if the prior product is subjected to material coating passivation treatment, the force transmitted by the hardness is large, so that the tail end can be injured.

In comparison, the front end of the bundle-shaped bristles in the direction that the brush body is sent into the body cavity is the bristles, the softness of the bristles meets the sampling standard and naturally meets the safety stimulation standard, and the bundle-shaped bristles have a good safety protection effect. Specifically, the safe distance can reach the complete length (1-3 cm) of the bristles, and the safe length can meet the misoperation allowable range of an ordinary inexperienced person, so that the inexperienced operator can safely use the brush under conventional misoperation with high probability.

The bristles are arranged on the bristle holder 332 in multiple states, so that the bristle bundle has two states of bunched furling and flower spreading. When the body cavity sampler is used, the bristles can be in a bundle shape in the process of entering the body cavity to reach a target sampling position, so that the stimulation of the body cavity wall in the entering process is reduced, the safety is improved, and the bristle function is protected; after reaching the sampling position, the bristles are controlled to be in a flower-shaped unfolding shape, and the omnibearing effective sampling including the position of the cervical orifice can be realized by rotating the handle 30.

Example 25:

one of the alternatives of the sampling, storage and transportation integrated device, the brush bundle expanding member comprises,

the attitude control assembly A is provided with a control end A1 arranged at the near end 31 of the handle, a transmission part and an execution part.

The embodiment specifically discloses a solution of an expanding mechanism, and the design point is that the problem of brush bundle expansion is solved by a control end A1 arranged at the proximal end 31 of the handle, and a posture control assembly A of a transmission part and an execution part. Wherein the control end is arranged at the proximal handle end 31, allowing free control of the brush bundle expansion. The separation of the insertion process and the state control of reaching the destination position is realized.

Example 26:

referring to fig. 14-16, one of the alternatives to the sampling integral storage and transportation device,

the executing part is provided with an air bag 43;

the transmission part is provided with an air channel 42;

the control end A1 is provided with a squeezing part 41;

the pressing part 41, the air passage 42 and the air bag are connected to form an airtight space, and external force acting on the pressing part 41 can enable the air bag to be changed from the first posture to the second posture.

Specifically, the air bag can be a homogeneous elastic air bag, and the inflatable volume is variable; the direction of the air bag is set according to the direction of the force required by the brush bundle deployment, and the direction of the air bag expansion is guided by setting the non-uniform weak track; or a pre-formed folding state is set, and the folding state is unfolded to form a second posture when the air pressure is increased. The scheme of driving the air bag by pneumatic transmission is adopted, the control structure is simple, the transmission part only needs an airtight cavity, and the product design freedom degree is high; the air transmission is equivalent to 'no transmission part', the product cost can be reduced, and the air transmission system also has positive effects on the aspects of medical antibiosis and system reliability.

Example 27:

and the restoring recessed portion is transformed from the recessed state to the expanded state by the increased air pressure from the inside of the airbag, and generates an outward thrust to the edge of the restoring recessed portion.

This solution can be used as one of the previously formed folded states in the above solutions.

Example 28:

referring to fig. 17-20, one of the alternatives for sampling the integrated storage and transportation device includes

This device need the censorship to detect the detection mechanism after the sample is accomplished, and the middle long-distance logistics transportation that probably exists, the block hasp can provide reliable and stable block lock state.

Example 29:

referring to fig. 17-20, one of the alternatives for the sampling, storage and transportation integrated device includes a handle thrust member 26 having a thrust attitude and a free attitude;

when the first end cover is in a closed state, the handle thrust piece 26 is in a thrust posture;

when the first end cover is in a non-covering state, the handle thrust piece 26 is in a free posture;

the thrust posture is provided with a limit bump 34, and the limit bump 34 is used for limiting the handle to extend and move to the sampling position in the reciprocating motion freedom degree;

the free posture can release the limit protrusion 34, and the limit of the limit protrusion 34 on the extension motion of the handle is released;

wherein, the handle extension motion is the motion of handle to sample position direction in the reciprocating motion degree of freedom.

In the existing design, the handle is pushed forward when the cap is opened, so that the sampling brush bundle 33 is seriously deformed due to extrusion with the cap, and the sampling brush bundle 33 is damaged and unusable in serious cases. The purpose of self-sampling is to provide privacy premises to reduce the complexity of the detection process to achieve wide coverage for the detected population, and to significantly increase the complexity of the event if the sampling brush 33 waiting for hands is damaged and needs to wait for a new brush mail again. The design of the thrust piece technically realizes that the handle cannot be pushed forwards before the cap is taken down, so that the condition that the sampling brush bundle 33 is damaged due to the fact that an operator is not professional or misoperation cannot occur.

Example 30:

one of the alternatives of the sampling, storage and transportation integrated device is that the end cover lock catch is a bidirectional elastic buckle 27 with elastic threshold force F1;

It appears that the cap cannot be removed under a force less than F1, but can be removed or closed freely under a force greater than F1. Provides a structure which is easy to operate and has the function of lock catch.

Example 31:

referring to fig. 17-20, one of the alternatives for the sampling all-in-one device, the end cap latch comprises,

a secondary lock having an unlocking force direction different from the external opposing force.

The secondary locking piece reinforces the function of the lock catch. The unlocking acting force directions of the secondary locking piece and the lock catch are different, the acting force provided by accidental violence/misoperation in the daily process is usually unidirectional although possibly large, and the design of different unlocking directions can ensure effective response to accidental violence.

Example 32:

one of the alternatives of the sampling, storage and transportation integrated device, the secondary locking piece comprises,

the rotation locking part 28 can be rotated and unlocked by applying unlocking force.

The design is unlocked in a rotating mode, and the safety is obviously improved compared with the common unlocking in a single direction. If the two-stage unlocking in a single direction is adopted, if two times of accidental violence in the whole process (including the whole logistics process) are exactly consistent with the direction of the force required by the two-stage unlocking, the mistaken unlocking can be caused to cause the cap to fall off, and the sample is unprotected. The probability of sustained, rotational accidental violence is significantly lower than unidirectional accidental violence (which may be instantaneous).

Example 33:

referring to fig. 1-20, a sample warehousing and transportation training device, comprising,

in the sample storage and transportation device,

a first chamber 10 and a first end cap;

in the sample storage and transportation device,

the control member 24 is released.

The cavity and the end cover of the training device of each embodiment can be partially simulated by the training device, and other functional components are not shown. The device can be used for being familiar with the operation method of the sampling device of each embodiment, particularly the operation touch and hand feeling, so that the strange feeling when the sampling device is used is experienced and sensed in advance, and the device has obvious positive effects on eliminating the psychological fear (uncertainty) of a person to be detected and improving the sampling quality.

Example 34:

one of the alternatives for the sample storage and transportation training apparatus includes,

wherein, the switch of the first light source starting circuit is connected with the release control member 24;

wherein the holding agent simulation display part is arranged at the corresponding position of the holding agent display part in the sample storage and transportation device.

The maintainer display is an important visual part of the storage and transportation device and the sampling, storage and transportation integrated device of the above embodiments, and the maintainer display is simulated to increase perception of the simulated device established by a user through the training device. The simulation aims to eliminate the mental disorder and familiarize the operation, and the simulation on the visual part can produce more positive effect on eliminating the mental disorder.

Example 35:

wherein the switch of the second light source turn-on circuit is connected with the release control member 24;

By adopting the light source to carry out multi-state simulation display on the display part, the user can feel familiar in advance with the state change which cannot be truly simulated.

Example 36:

the shooting surface.

Example 37:

Example 38:

one of the alternatives for the sample handling training apparatus includes,

Example 39:

a sampling, storage and transportation integrated training device comprises,

in the sampling, storing and transporting integrated device,

a first chamber 10;

a first end cap;

a handle; and the combination of (a) and (b),

The training device simulates the handle, i.e. the control end, of the device of the above embodiments, without the presence of other functional components. The device can be used for familiarizing the operation method of the sampling device of each embodiment, particularly the operation touch and hand feeling, so that the strange feeling when the sampling device is used is experienced and sensed in advance, and the device has obvious positive effects on eliminating the psychological fear (uncertainty) of a person to be detected and improving the sampling quality.

Example 40:

one of the alternatives for the sampling, storage and transportation integrated training device, includes,

Example 41:

the handle thrust piece 26 in the sampling, storage and transportation integrated device.

Example 42:

one of the alternatives for the sampling, storage and transportation integrated training device includes,

Example 43:

the rotation locking part 28 of the sampling, storing and transporting integrated device.

The above four embodiments provide simulated training in different aspects and to different degrees for various operational aspects of the sampling device operation process.

In the description of the embodiments of the present invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "center", "top", "bottom", "inner", "outer", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for the purpose of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus should not be construed as limiting the present invention. Where "inside" refers to an interior or enclosed area or space. "periphery" refers to an area around a particular component or a particular area.

In the description of the embodiments of the present invention, the terms "first", "second", "third", and "fourth" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first", "second", "third", "fourth" may explicitly or implicitly include one or more of the features. In the description of the present invention, "a plurality" means two or more unless otherwise specified.

In the description of the embodiments of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "assembled" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

The particular features, structures, materials, or characteristics may be combined in any suitable manner in any one or more embodiments or examples throughout the description of the embodiments of the invention.

In the description of the embodiments of the present invention, it should be understood that "-" and "-" indicate the same range as two numerical values, and the range includes the endpoints. For example, "A-B" means a range greater than or equal to A and less than or equal to B. "A to B" means a range of A or more and B or less.

In the description of the embodiments of the present invention, the term "and/or" herein is only one kind of association relationship describing an associated object, and means that there may be three kinds of relationships, for example, a and/or B, and may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the character "/" herein generally indicates that the former and latter related objects are in an "or" relationship.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The sample storage and transportation device is characterized by comprising,

a first end cap operable to seal the first port;

wherein the first port can be used for putting in and/or taking out a sample;

wherein the release port can release the sample-retaining agent toward the first cavity;

the one-way valve body has the function of discharging gas from the inside of the first cavity to the outside of the cavity in a one-way mode;

the second cavity comprises a first cavity body and a second cavity body,

a holding agent air bag for storing a gaseous holding agent;

the second cavity is arranged inside the first end cover;

the first end cap includes a first end cap body,

a release control member having a control portion to which an external force acts to open the release port;

wherein the first display portion has a first and a second distinguishable maintainer state;

when the concentration of the retention agent in the first cavity is not higher than the concentration threshold, the first display part displays a second retention agent state.

2. The sample storage and transportation device of claim 1, comprising,

a sample display member having a second display portion for displaying a sample of a predetermined concentration;

when the concentration of the sample in the first cavity is not higher than the concentration threshold, the second display part displays a second sample state.

3. The specimen storage and transportation device of claim 2, comprising,

4. The specimen storage and transportation device according to claim 3, having,

5. The specimen storage and transportation device according to claim 4,

the sample storage device is tubular with an open proximal end and an open distal end;

wherein the first end cap is arranged at the far end;

wherein, the check valve body is arranged at the near end.

6. The sample storage and transportation apparatus of claim 5,

the sample storage and transportation device is in a circular tube shape;

7. The sample storage and transportation device of claim 6, comprising,

a pseudo-intervention section having an intervention region;

wherein the intervening region may form visible differential information;

8. The specimen storage and transportation device according to claim 7,

the intervention area of the pseudo-intervention part is a graffiti area;

wherein the visual difference information is free graffiti information.

9. The specimen storage and transportation device of claim 8, comprising,

10. A sampling, storage and transportation integrated device comprises,

a first cavity having a storage space for accommodating a sample and an open first port, being a tubular tube L having an open proximal end and an open distal end;

a first end cap operable to seal off the first port, wherein the first port is operable to place and/or remove a sample;

a second cavity having a storage space containing a sample-retaining agent and a sample-retaining agent release port;

the second cavity comprises a first cavity body and a second cavity body,

a retention agent balloon for storing a gaseous retention agent;

the second cavity is arranged inside the first end cover;

the first end cap includes a first end cap body,

a release control member having a control portion that can open the release port by an external force acting on the control portion;

when the concentration of the maintainer in the first cavity is not higher than the concentration threshold, the first display part displays a second maintainer state;

which is characterized by comprising the following steps of,

a handle having a proximal handle end and a distal handle end;

the handle and the sampling brush bundle are arranged in the tube L;

wherein the sampling brush bundle is close to the far end of the tube L, and the near end of the handle is close to the near end of the tube L;

wherein the handle has a freedom of reciprocating motion in the tube L along the axial direction of the tube L, and extends towards the far end of the tube to a sampling position and retracts towards the near end of the tube to an introduction position;

11. The sampling, storage and transportation integrated device according to claim 10, comprising,

the rubber sleeve is arranged at the end part of the near end of the tube L or the inner wall of the tube L close to the near end;

12. The sampling, storage and transportation integrated device according to claim 11, comprising,

a sample display;

a second display unit for displaying a sample having a predetermined density;

13. The sampling, storage and transportation integrated device according to claim 12, comprising,

14. The sampling, storage and transportation integrated device according to claim 13, comprising,

and the sampling, storing and transporting integrated device can be freely placed on a background plane and is stable in the shooting attitude.

15. The sampling, storage and transportation integrated device according to claim 14, comprising,

a fake intervention section;

having an intervention region;

wherein the intervening region may form visible differential information;

16. The sampling, storage and transportation integrated device according to claim 15, comprising,

17. The sampling, storage and transportation integrated unit of claim 16, comprising,

18. The integrated sampling, storage and transportation device according to claim 17, wherein the brush bundle expansion member comprises,

the attitude control assembly A is provided with a control end A1 arranged at the near end of the handle, a transmission part and an execution part.

19. The sampling, storage and transportation integrated device according to claim 18,

the executing part is provided with an air bag;

the transmission part is provided with an air passage;

the control end A1 is provided with a squeezing part;

20. The sampling, storage and transportation integrated device according to claim 19,

21. A sampling, storage and transportation integrated device according to any one of claims 10 to 20, comprising

22. The sampling, storage and transportation integrated unit of claim 21, comprising,

a handle thrust member having a thrust attitude and a free attitude;

the free posture can release the limiting protrusion, and the limitation of the limiting protrusion on the extension motion of the handle is released;

23. The integrated sampling, storage and transportation device according to claim 22, wherein the end cap lock catch is a bi-directional elastic lock catch having an elastic threshold force F1;

24. The integrated sampling, storage and transportation device of claim 23, wherein the end cap lock comprises,

25. The sampling, storage and transportation integrated device according to claim 24, wherein the secondary lock comprises,

26. The sample storage and transportation training device is characterized by comprising,

the first end cover can be used for plugging the first port;

wherein the first port can be used for putting in and/or taking out a sample;

the second cavity comprises a first cavity body and a second cavity body,

a retention agent balloon for storing a gaseous retention agent;

the second cavity is arranged inside the first end cover;

the first end cap includes a first end cap body,

27. The specimen storage and transportation training device of claim 26, comprising,

the holding agent simulation display piece is provided with a first display light source and a first light source starting circuit;

the switch of the first light source starting circuit is connected with the release control piece;

wherein, the holding agent simulation display piece is arranged at the corresponding position of the holding agent display piece.

28. The specimen storage and transportation training device of claim 26 or 27, comprising,

the switch of the second light source starting circuit is connected with the release control piece;

wherein, the sample simulation display piece is arranged at the corresponding position of the sample display piece.

29. The specimen storage and transportation training device of claim 28, comprising a camera surface, the first display portion and the second display portion being visible in a direction facing the camera surface.

30. The specimen storage and transportation training device of claim 29, comprising,

a pseudo-intervention section having an intervention region;

wherein the intervening region may form visible differential information;

31. A sample storage and transportation training apparatus as claimed in claim 30 comprising an access lock covering and locking the access area.

32. The sampling, storage and transportation integrated training device is characterized by comprising,

the first end cover can be used for plugging the first port;

wherein the first port can be used for putting in and/or taking out a sample;

the second cavity comprises a first cavity body and a second cavity body,

a retention agent balloon for storing a gaseous retention agent;

the second cavity is arranged inside the first end cover;

the first end cap includes a first end cap body,

a handle; and a brush bundle expanding member, the brush bundle expanding member including,

33. The unitary sampling, storage and transportation training device of claim 32, comprising,

34. A sampling, storage and transportation integrated training device as in claim 33, comprising,

a thrust piece of the handle is arranged on the handle,

having a thrust attitude and a free attitude;

when the first end cover is in a covered state, the handle thrust piece is in a thrust attitude;

35. A sample storage and transportation integrated training device according to claim 33 or 34, comprising,

36. A sampling, storage and transportation integrated training device according to claim 35, comprising,