CN114223896A - Red date triterpenic acid chewable tablet and preparation method thereof - Google Patents
Red date triterpenic acid chewable tablet and preparation method thereof Download PDFInfo
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- CN114223896A CN114223896A CN202111367373.9A CN202111367373A CN114223896A CN 114223896 A CN114223896 A CN 114223896A CN 202111367373 A CN202111367373 A CN 202111367373A CN 114223896 A CN114223896 A CN 114223896A
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- 239000002253 acid Substances 0.000 title claims abstract description 103
- 239000007910 chewable tablet Substances 0.000 title claims abstract description 43
- 229940068682 chewable tablet Drugs 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000008187 granular material Substances 0.000 claims abstract description 85
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 50
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 50
- 239000000287 crude extract Substances 0.000 claims abstract description 48
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000007779 soft material Substances 0.000 claims abstract description 35
- 239000000843 powder Substances 0.000 claims abstract description 34
- 241001247821 Ziziphus Species 0.000 claims abstract description 30
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 25
- 235000010355 mannitol Nutrition 0.000 claims abstract description 25
- 239000005715 Fructose Substances 0.000 claims abstract description 24
- 229930091371 Fructose Natural products 0.000 claims abstract description 24
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims abstract description 24
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 claims abstract description 22
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 claims abstract description 22
- 238000007873 sieving Methods 0.000 claims abstract description 22
- 229960001462 sodium cyclamate Drugs 0.000 claims abstract description 22
- 238000001035 drying Methods 0.000 claims abstract description 21
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 20
- 239000001116 FEMA 4028 Substances 0.000 claims abstract description 20
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 20
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims abstract description 20
- 229960004853 betadex Drugs 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000000227 grinding Methods 0.000 claims abstract description 12
- 238000004537 pulping Methods 0.000 claims abstract description 11
- 230000001954 sterilising effect Effects 0.000 claims abstract description 11
- 239000002245 particle Substances 0.000 claims abstract description 4
- 150000003648 triterpenes Chemical class 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 238000012545 processing Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 238000002481 ethanol extraction Methods 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
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- 238000002156 mixing Methods 0.000 abstract description 5
- 238000002791 soaking Methods 0.000 abstract description 3
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- 238000011156 evaluation Methods 0.000 description 8
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- 206010028980 Neoplasm Diseases 0.000 description 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 229930003944 flavone Natural products 0.000 description 2
- 150000002212 flavone derivatives Chemical class 0.000 description 2
- 235000011949 flavones Nutrition 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- -1 polyphenol flavonoid Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000021424 Jujube vinegar Nutrition 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 238000012356 Product development Methods 0.000 description 1
- 235000006545 Ziziphus mauritiana Nutrition 0.000 description 1
- 244000126002 Ziziphus vulgaris Species 0.000 description 1
- 235000008529 Ziziphus vulgaris Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000036436 anti-hiv Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000018927 edible plant Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 150000008130 triterpenoid saponins Chemical class 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
- A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a red date triterpenic acid chewable tablet and a preparation method thereof, wherein the red date triterpenic acid chewable tablet comprises the following components in parts by weight: 50 parts of beta-cyclodextrin, 1-2 parts of red date triterpenic acid crude extract, 0.05 part of sodium cyclamate, 10-13 parts of fructose, 1-2 parts of magnesium stearate and 35-40 parts of D-mannitol. Soaking dried fructus Jujubae in water, removing core, pulping, reflux-extracting with 60% ethanol for 3 hr to obtain fructus Jujubae triterpenic acid crude extract, vacuum-filtering to remove residue, concentrating under reduced pressure to remove ethanol, and cold drying to obtain fructus Jujubae triterpenic acid crude extract; adding sodium cyclamate, D-mannitol, fructose and beta-cyclodextrin into the crude extract of the triterpenic acid of red dates, mixing uniformly, and carrying out superfine grinding to obtain superfine powder with the particle size of 15-25 mu m; adding water to adjust to prepare soft materials, sieving with a 12-mesh sieve and granulating; drying the granules in an oven at 45-50 ℃ to ensure that the moisture in the granules reaches 3 percent, and then sieving the granules by a 16-mesh sieve to obtain whole granules; adding magnesium stearate into the granules, tabletting and sterilizing to obtain the red jujube triterpenic acid chewable tablet. The chewable tablet disclosed by the invention is rich in triterpenic acid content and expands the application field of red jujube triterpenic acid.
Description
Technical Field
The invention relates to application of active substances in agricultural products, in particular to a red date triterpenic acid chewable tablet and a preparation method thereof.
Background
The red dates, commonly called as the Chinese dates, are edible plant fruits growing locally in China and have a history of more than four thousand years. The red date contains nutrient components such as vitamins, proteins, minerals, saccharides and the like, and also contains various bioactive components such as flavone, saponin, cyclic adenosine monophosphate, triterpenoids, polysaccharide, alkaloid and the like. As a material with homology of medicine and food, the red date is popular among people due to good taste, extremely high nutritional value and medicine property, such as cancer resistance, liver protection, prevention and treatment of cardiovascular and cerebrovascular diseases.
The processing of domestic red date is mostly the primary processing of red date, and the product is mostly the primary processing product, and the intensive processing product is less. The red date product mainly takes dry products as main materials, and the product is leisure food which can be made by each family, such as dry red dates, preserved red dates, candied red dates and the like. A few food enterprises can produce products such as jujube wine, jujube vinegar, jujube beverage and the like, but the scale is small, the variety is few, the market share is low, and the deep and refined products of the jujubes are in urgent need of development. The triterpenic acid exists in the form of triterpenoid saponin in plants, and has strong anticancer, anti-tumor, liver-protecting, cardiovascular and cerebrovascular protecting, immunity promoting, and anti-HIV effects. According to the invention, the triterpenic acid in the red dates is extracted and developed into the red date triterpenic acid chewable tablets, so that the utilization rate and the added value of the red dates are improved, and the deep processing process of agricultural products is accelerated.
Disclosure of Invention
The technical problem to be solved is as follows: the invention aims to provide a red date triterpenic acid chewable tablet and a preparation method thereof, so that the triterpenic acid extraction efficiency is high, and the red date triterpenic acid chewable tablet is prepared by deep processing, the application value of red date triterpenic acid is improved, and a conversion mode is provided for deep processing of agricultural products.
The technical scheme is as follows: a red date triterpenic acid chewable tablet comprises the following components in parts by weight: 50 parts of beta-cyclodextrin, 1-2 parts of red date triterpenic acid crude extract, 0.05 part of sodium cyclamate, 10-13 parts of fructose, 1-2 parts of magnesium stearate and 35-40 parts of D-mannitol. Further, the red date triterpenic acid chewable tablet is composed of the following components in parts by weight: 50 parts of beta-cyclodextrin, 1.5 parts of red jujube triterpenic acid crude extract, 0.05 part of sodium cyclamate, 10.5 parts of fructose, 1.5 parts of magnesium stearate and 36.5 parts of D-mannitol. Further, the preparation method of the red date triterpenic acid chewable tablet comprises the following steps:
(1) red jujube triterpenic acid crude extract: soaking dried fructus Jujubae in water, removing core, pulping, reflux-extracting with 60% ethanol for 3 hr, removing residue, concentrating the extractive solution, removing ethanol, and freeze-drying to obtain fructus Jujubae triterpenic acid crude extract;
(2) manufacturing a soft material: adding sodium cyclamate, D-mannitol, fructose and beta-cyclodextrin into the crude extract of the triterpenic acid of the red dates, uniformly mixing, carrying out superfine grinding to obtain superfine powder, adding water into the superfine powder, and adjusting humidity to prepare a soft material;
(3) and (3) granulating: sieving the soft material with 12 mesh sieve to granulate to obtain granules; drying the granules in an oven at the temperature of 45-50 ℃ to enable the moisture in the granules to reach 3% to obtain secondary granules; sieving the secondary granules through a 16 mesh sieve to obtain whole granules;
(4) and (3) finished product: adding magnesium stearate into the granules, tabletting to obtain a flaky sample, and sterilizing the flaky sample to obtain the red date triterpenic acid chewable tablet.
Further, the feed-liquid ratio of ethanol extraction in the step (1) is 1: 20.
Furthermore, the particle size of the superfine powder in the step (2) is 15-25 μm.
Further, the soft material in the step (2) has a hardness degree that the soft material is held by hand to be agglomerated and is dispersed by light pressure.
The red jujube triterpenic acid chewable tablet and the preparation method thereof are applied to research of active substances in agricultural products and deep processing.
Has the advantages that: aiming at the current situation that no product development exists in the aspect of red date triterpenic acid, the invention adopts red date triterpenic acid crude extract, D-mannitol, magnesium stearate and other materials, and obtains the preparation method of the red date triterpenic acid chewable tablet through methods of superfine grinding, mixing, granulation, drying, pressing and the like.
The invention extracts the triterpenic acid in the red dates to develop the triterpenic acid into the chewable tablets of the red dates, can fully utilize the red dates which are lost in the market, improves the utilization rate and the added value of the defective fruits of the red dates, and has important significance for improving the quality and the efficiency of the red date industry.
Detailed Description
Example 1
(1) Red jujube triterpenic acid crude extract: soaking dried red dates in water, removing cores and pulping, mixing the dried red dates with a mixing ratio of 1:20, performing reflux extraction with 60% ethanol for 3h, removing residue by suction filtration, and concentrating the extracted triterpene acid solution by rotary evaporator to remove ethanol. Spreading the concentrated ethanol-removed extract in a plate, freezing at-80 deg.C, and drying with a freeze dryer to obtain fructus Jujubae triterpenic acid crude extract;
through detection, the total triterpenic acid content of the red jujube triterpenic acid crude extract is about 0.078mg/g, the total flavone content is about 0.108mg/g, the total phenol content is about 9.221mg/g, and the total sugar content is about 5.42 mg/g.
(2) The following raw materials were prepared: 50 parts of beta-cyclodextrin, 1.5 parts of red date triterpenic acid crude extract, 0.05 part of sodium cyclamate, 10.5 parts of fructose, 1.5 parts of magnesium stearate and 36.5 parts of D-mannitol;
(3) manufacturing a soft material: adding sodium cyclamate, D-mannitol, fructose and beta-cyclodextrin into the crude extract of the red jujube triterpenic acid, carrying out superfine grinding to obtain superfine powder, wherein the grain diameter of the superfine powder is 15 mu m, adding water into the superfine powder, and adjusting the humidity to prepare a soft material;
(4) and (3) granulating: sieving the soft material with 12 mesh sieve to granulate to obtain granules; drying the granules in an oven at the temperature of 45 ℃ to enable the moisture in the granules to reach 3% to obtain secondary granules; sieving the secondary granules through a 16 mesh sieve to obtain whole granules;
(5) and (3) finished product: adding magnesium stearate into the granules, tabletting to obtain a flaky sample, and sterilizing the flaky sample to obtain the red date triterpenic acid chewable tablet.
Example 2
(1) Red jujube triterpenic acid crude extract: removing cores of the dried red dates, and pulping the red dates in a proportion of 1: extracting 20 material solution with 60% ethanol under reflux for 3 hr, filtering to remove residue, and concentrating the extracted triterpene acid solution with rotary evaporator to remove ethanol. Spreading the concentrated ethanol-removed extract in a culture dish, freezing at-80 deg.C, wrapping the holes with preservative film, and drying the concentrated solution with a freeze dryer to obtain fructus Jujubae triterpenic acid crude extract;
(2) the following raw materials were prepared: 50 parts of beta-cyclodextrin, 1 part of red date triterpenic acid crude extract, 0.05 part of sodium cyclamate, 10 parts of fructose, 1 part of magnesium stearate and 35 parts of D-mannitol;
(3) manufacturing a soft material: adding sodium cyclamate, D-mannitol, fructose and beta-cyclodextrin into the crude extract of the red jujube triterpenic acid, carrying out superfine grinding to obtain superfine powder, wherein the grain diameter of the superfine powder is 25 mu m, adding water into the superfine powder, and adjusting the humidity to prepare a soft material;
(4) and (3) granulating: sieving the soft material with 12 mesh sieve to granulate to obtain granules; drying the granules in an oven at the temperature of 50 ℃ to enable the moisture in the granules to reach 3% to obtain secondary granules; sieving the secondary granules through a 16 mesh sieve to obtain whole granules;
(5) and (3) finished product: adding magnesium stearate into the granules, tabletting to obtain a flaky sample, and sterilizing the flaky sample to obtain the red date triterpenic acid chewable tablet.
Example 3
(1) Red jujube triterpenic acid crude extract: removing cores of the dried red dates, and pulping the red dates in a proportion of 1: extracting 20 material solution with 60% ethanol under reflux for 3 hr, filtering to remove residue, and concentrating the extracted triterpene acid solution with rotary evaporator to remove ethanol. Spreading the concentrated ethanol-removed extract in a culture dish, freezing at-80 deg.C, wrapping the holes with preservative film, and drying the concentrated solution with a freeze dryer to obtain fructus Jujubae triterpenic acid crude extract;
(2) the following raw materials were prepared: 50 parts of beta-cyclodextrin, 2 parts of red date triterpenic acid crude extract, 0.05 part of sodium cyclamate, 13 parts of fructose, 2 parts of magnesium stearate and 40 parts of D-mannitol;
(3) manufacturing a soft material: adding sodium cyclamate, D-mannitol, fructose and beta-cyclodextrin into the crude extract of the triterpenic acid of the red dates, carrying out superfine grinding to obtain superfine powder, wherein the grain diameter of the superfine powder is 20 microns, adding water into the superfine powder, and adjusting the humidity to prepare a soft material;
(4) and (3) granulating: sieving the soft material with 12 mesh sieve to granulate to obtain granules; drying the granules in an oven at the temperature of 45 ℃ to enable the moisture in the granules to reach 3% to obtain secondary granules; sieving the secondary granules through a 16 mesh sieve to obtain whole granules;
(5) and (3) finished product: adding magnesium stearate into the granules, tabletting to obtain a flaky sample, and sterilizing the flaky sample to obtain the red date triterpenic acid chewable tablet.
Example 4
(1) Red jujube triterpenic acid crude extract: removing cores of the dried red dates, and pulping the red dates in a proportion of 1: extracting 20 material solution with 60% ethanol under reflux for 3 hr, filtering to remove residue, and concentrating the extracted triterpene acid solution with rotary evaporator to remove ethanol. Spreading the concentrated ethanol-removed extract in a culture dish, freezing at-80 deg.C, wrapping the holes with preservative film, and drying the concentrated solution with a freeze dryer to obtain fructus Jujubae triterpenic acid crude extract;
(2) the following raw materials were prepared: 50 parts of beta-cyclodextrin, 1 part of red date triterpenic acid crude extract, 0.05 part of sodium cyclamate, 12 parts of fructose, 2 parts of magnesium stearate and 36 parts of D-mannitol;
(3) manufacturing a soft material: adding sodium cyclamate, D-mannitol, fructose and beta-cyclodextrin into the crude extract of the red jujube triterpenic acid, carrying out superfine grinding to obtain superfine powder, wherein the grain diameter of the superfine powder is 18 mu m, adding water into the superfine powder, and adjusting the humidity to prepare a soft material;
(4) and (3) granulating: sieving the soft material with 12 mesh sieve to granulate to obtain granules; drying the granules in an oven at the temperature of 50 ℃ to enable the moisture in the granules to reach 3% to obtain secondary granules; sieving the secondary granules through a 16 mesh sieve to obtain whole granules;
(5) and (3) finished product: adding magnesium stearate into the granules, tabletting to obtain a flaky sample, and sterilizing the flaky sample to obtain the red date triterpenic acid chewable tablet.
Example 5
(1) Red jujube triterpenic acid crude extract: removing cores of the dried red dates, and pulping the red dates in a proportion of 1: extracting 20 material solution with 60% ethanol under reflux for 3 hr, filtering to remove residue, and concentrating the extracted triterpene acid solution with rotary evaporator to remove ethanol. Spreading the concentrated ethanol-removed extract in a culture dish, freezing at-80 deg.C, wrapping the holes with preservative film, and drying the concentrated solution with a freeze dryer to obtain fructus Jujubae triterpenic acid crude extract;
(2) the following raw materials were prepared: 50 parts of beta-cyclodextrin, 2 parts of red date triterpenic acid crude extract, 0.05 part of sodium cyclamate, 10 parts of fructose, 1 part of magnesium stearate and 40 parts of D-mannitol;
(3) manufacturing a soft material: adding sodium cyclamate, D-mannitol, fructose and beta-cyclodextrin into the crude extract of the triterpenic acid of the red dates, carrying out superfine grinding to obtain superfine powder, wherein the grain diameter of the superfine powder is 20 microns, adding water into the superfine powder, and adjusting the humidity to prepare a soft material;
(4) and (3) granulating: sieving the soft material with 12 mesh sieve to granulate to obtain granules; drying the granules in an oven at the temperature of 50 ℃ to enable the moisture in the granules to reach 3% to obtain secondary granules; sieving the secondary granules through a 16 mesh sieve to obtain whole granules;
(5) and (3) finished product: adding magnesium stearate into the granules, tabletting to obtain a flaky sample, and sterilizing the flaky sample to obtain the red date triterpenic acid chewable tablet.
Comparative example 1
(1) Red jujube triterpenic acid crude extract: removing cores of the dried red dates, and pulping the red dates in a proportion of 1: extracting 20 material solution with 60% ethanol under reflux for 3 hr, filtering to remove residue, and concentrating the extracted triterpene acid solution with rotary evaporator to remove ethanol. Spreading the concentrated ethanol-removed extract in a culture dish, freezing at-80 deg.C, wrapping the holes with preservative film, and drying the concentrated solution with a freeze dryer to obtain fructus Jujubae triterpenic acid crude extract;
(2) the following raw materials were prepared: 50 parts of beta-cyclodextrin, 1.5 parts of red date triterpenic acid crude extract, 10.5 parts of fructose, 1.5 parts of magnesium stearate, 10 parts of D-mannitol and 25 parts of milk powder;
(3) manufacturing a soft material: adding D-mannitol, fructose, milk powder and beta-cyclodextrin into the crude extract of the triterpenic acid of the red dates, carrying out superfine grinding to obtain superfine powder, wherein the particle size of the superfine powder is 15 mu m, adding water into the superfine powder, and adjusting the humidity to prepare a soft material;
(4) and (3) granulating: sieving the soft material with 12 mesh sieve to granulate to obtain granules; drying the granules in an oven at the temperature of 45 ℃ to enable the moisture in the granules to reach 3% to obtain secondary granules; sieving the secondary granules through a 16 mesh sieve to obtain whole granules;
(5) and (3) finished product: adding magnesium stearate into the granules, tabletting to obtain a flaky sample, and sterilizing the flaky sample to obtain the red date triterpenic acid chewable tablet.
Sensory evaluation shows that the milk powder is used as a flavoring agent, and although the chewable tablet has certain milk flavor, the chewable tablet becomes fragile and easy to remove dregs, so that the mouthfeel and the tissue state are deteriorated.
Comparative example 2
(1) Red jujube triterpenic acid crude extract: removing cores of the dried red dates, and pulping the red dates in a proportion of 1: extracting 20 material solution with 60% ethanol under reflux for 3 hr, filtering to remove residue, and concentrating the extracted triterpene acid solution with rotary evaporator to remove ethanol. Spreading the concentrated ethanol-removed extract in a culture dish, freezing at-80 deg.C, wrapping the holes with preservative film, and drying the concentrated solution with a freeze dryer to obtain fructus Jujubae triterpenic acid crude extract;
(2) the following raw materials were prepared: 50 parts of microcrystalline cellulose, 1.5 parts of crude extract of red date triterpenic acid, 0.05 part of sodium cyclamate, 10.5 parts of fructose, 1.5 parts of magnesium stearate and 36.5 parts of D-mannitol;
(3) manufacturing a soft material: adding sodium cyclamate, D-mannitol, fructose and microcrystalline cellulose into the crude extract of the red jujube triterpenic acid, carrying out superfine grinding to obtain superfine powder, wherein the grain diameter of the superfine powder is 15 mu m, adding water into the superfine powder, and adjusting the humidity to prepare a soft material;
(4) and (3) granulating: sieving the soft material with 12 mesh sieve to granulate to obtain granules; drying the granules in an oven at the temperature of 50 ℃ to enable the moisture in the granules to reach 3% to obtain secondary granules; sieving the secondary granules through a 16 mesh sieve to obtain whole granules;
(5) and (3) finished product: adding magnesium stearate into the granules, tabletting to obtain a flaky sample, and sterilizing the flaky sample to obtain the red date triterpenic acid chewable tablet.
Sensory evaluation revealed that the use of microcrystalline cellulose as a filler provided good color and luster to the chewable tablet, but caused the chewable tablet to become brittle and easily to be slagged off, resulting in poor taste and texture, and also failed to provide good flavor.
Comparative example 3
(1) Red jujube triterpenic acid crude extract: removing cores of the dried red dates, and pulping the red dates in a proportion of 1: extracting 20 material solution with 60% ethanol under reflux for 3 hr, filtering to remove residue, and concentrating the extracted triterpene acid solution with rotary evaporator to remove ethanol. Spreading the concentrated ethanol-removed extract in a culture dish, freezing at-80 deg.C, wrapping the holes with preservative film, and drying the concentrated solution with a freeze dryer to obtain fructus Jujubae triterpenic acid crude extract;
(2) the following raw materials were prepared: 50 parts of starch, 1.5 parts of crude extract of red date triterpenic acid, 0.05 part of sodium cyclamate, 10.5 parts of fructose, 1.5 parts of magnesium stearate and 36.5 parts of D-mannitol;
(3) manufacturing a soft material: adding sodium cyclamate, D-mannitol, fructose and starch into the crude extract of the triterpenic acid of the red dates, carrying out superfine grinding to obtain superfine powder, wherein the grain diameter of the superfine powder is 15 microns, adding water into the superfine powder, and adjusting the humidity to prepare a soft material;
(4) and (3) granulating: sieving the soft material with 12 mesh sieve to granulate to obtain granules; drying the granules in an oven at the temperature of 45 ℃ to enable the moisture in the granules to reach 3% to obtain secondary granules; sieving the secondary granules through a 16 mesh sieve to obtain whole granules;
(5) and (3) finished product: adding magnesium stearate into the granules, tabletting to obtain a flaky sample, and sterilizing the flaky sample to obtain the red date triterpenic acid chewable tablet.
Sensory evaluation revealed that the use of starch as a filler resulted in poor color of the chewable tablet, leading to poor mouthfeel and texture, while good flavor was not obtained.
Sensory evaluation was performed on the above examples and comparative examples, table 1 shows a formulation for making chewable tablets, and the evaluation results are shown in table 3 for each example and comparative example by using the sensory evaluation indexes shown in table 2.
TABLE 1 formula table for making chewable tablets
TABLE 2 sensory evaluation criteria of chewable tablet containing fructus Jujubae triterpenic acid
TABLE 3 organoleptic evaluation score chart of chewable tablet containing fructus Jujubae triterpenic acid
The red jujube triterpenic acid chewable tablet prepared by the method has the advantages of complete process and simple and convenient operation, and can be used for industrial production. The product is rich in triterpenic acid and polyphenol flavonoid active ingredients, and the triterpenic acid has important physiological functions of inhibiting bacteria, protecting liver, resisting cancer, enhancing the immunity of the organism and the like; the polyphenol flavonoids have antioxidant effect.
The embodiments of the present invention are not exhaustive, and those skilled in the art can select them from the prior art.
The above disclosure is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and shall be covered by the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the above claims.
Claims (7)
1. The red date triterpenic acid chewable tablet is characterized by comprising the following components in parts by weight: 50 parts of beta-cyclodextrin, 1-2 parts of red date triterpenic acid crude extract, 0.05 part of sodium cyclamate, 10-13 parts of fructose, 1-2 parts of magnesium stearate and 35-40 parts of D-mannitol.
2. The red jujube triterpenic acid chewable tablet of claim 1 is characterized by comprising the following components in parts by weight: 50 parts of beta-cyclodextrin, 1.5 parts of red jujube triterpenic acid crude extract, 0.05 part of sodium cyclamate, 10.5 parts of fructose, 1.5 parts of magnesium stearate and 36.5 parts of D-mannitol.
3. The preparation method of the red jujube triterpenic acid chewable tablet as claimed in claim 1, wherein the method comprises the following steps:
(1) red jujube triterpenic acid crude extract: removing core of dried fructus Jujubae, pulping, reflux-extracting with 60% ethanol for 3 hr, removing residue, concentrating the extracted triterpene acid solution, removing ethanol, and freeze-drying to obtain fructus Jujubae triterpene acid crude extract;
(2) manufacturing a soft material: adding sodium cyclamate, D-mannitol, fructose and beta-cyclodextrin into the crude extract of the triterpenic acid of the red dates, carrying out superfine grinding to obtain superfine powder, adding water into the superfine powder, and adjusting humidity to prepare a soft material;
(3) and (3) granulating: sieving the soft material with 12 mesh sieve to granulate to obtain granules; drying the granules in an oven at the temperature of 45-50 ℃ to enable the moisture in the granules to reach 3% to obtain secondary granules; sieving the secondary granules through a 16 mesh sieve to obtain whole granules;
(4) and (3) finished product: adding magnesium stearate into the granules, tabletting to obtain a flaky sample, and sterilizing the flaky sample to obtain the red date triterpenic acid chewable tablet.
4. The preparation method of the red jujube triterpenic acid chewable tablet as claimed in claim 3, wherein the ethanol extraction in the step (1) is performed at a ratio of 1: 20.
5. The method for preparing chewable tablet of red jujube triterpenic acid according to claim 3, wherein the particle size of the superfine powder in the step (2) is 15 μm-25 μm.
6. The method for preparing chewable tablets containing red date triterpenic acid according to claim 3, wherein the soft material in the step (2) is soft and hard, and the soft material is agglomerated by hand and is dispersed by light pressure.
7. The red jujube triterpenic acid chewable tablet and the preparation method thereof of any one of claims 1 to 6 are applied to deep processing of red jujubes.
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