CN114200369B - Magnetic resonance imaging system and method integrating nerve regulation and control and radio frequency coil - Google Patents
Magnetic resonance imaging system and method integrating nerve regulation and control and radio frequency coil Download PDFInfo
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- CN114200369B CN114200369B CN202111547457.0A CN202111547457A CN114200369B CN 114200369 B CN114200369 B CN 114200369B CN 202111547457 A CN202111547457 A CN 202111547457A CN 114200369 B CN114200369 B CN 114200369B
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Abstract
The application discloses a magnetic resonance imaging system and method integrating nerve regulation and control and a head magnetic resonance radio frequency coil, which are used for carrying out magnetic resonance imaging by combining other related brain function intervention regulation and control means on the basis of traditional function magnetic resonance imaging. The system comprises: a frame having a first stimulation device mounting area and a second device mounting area; a head magnetic resonance radio frequency coil comprising a flexible wearable base and a radio frequency coil disposed in the flexible wearable base, the head magnetic resonance radio frequency coil having a first channel and a second channel; the stimulation device comprises a first stimulation device and a second stimulation device, the first stimulation device and the second stimulation device are respectively arranged in the first device installation area and the second device installation area at the same time or in a time-sharing mode, the first stimulation device is electromagnetic stimulation device and acts on a tested person through the first channel, and the second stimulation device is visual stimulation device and acts on the tested person through the second channel.
Description
Technical Field
Embodiments of the application relate to magnetic resonance imaging systems, methods and head magnetic resonance radio frequency coils for integrated neuromodulation.
Background
Traditional functional magnetic resonance imaging (fMRI) applied in the field of clinical imaging is task state imaging with visual stimuli (allowing the subject to see some cognitive or emotional pictures at some point in time). fMRI is greatly limited by whether the subject looks at or has seen the test picture, and therefore the results are highly subjective. On the other hand, in the field of treating mental diseases by means of nerve regulation, brain function intervention regulation can be performed by generating physical fields (such as magnetic fields, currents, ultrasound and the like) through electromagnetic equipment, but the methods belong to positioning treatment, that is, brain targets acted by the physical fields are predetermined. However, the individual differences of human brain functions are very different, and the above brain function intervention regulation means are difficult to realize individual accurate medical treatment.
Disclosure of Invention
The embodiment of the application aims to provide a magnetic resonance imaging system, a magnetic resonance imaging method and a head magnetic resonance radio frequency coil integrating nerve regulation and control, which are used for carrying out magnetic resonance imaging by combining other related brain function intervention regulation and control means on the basis of traditional function magnetic resonance imaging. Therefore, the limitation of the traditional functional magnetic resonance imaging in visual stimulation can be broken through, and meanwhile, the related brain functional intervention regulation and control means can be changed from a passive positioning treatment means to a functional magnetic resonance imaging stimulation means, so that an individualized functional target point can be conveniently defined, and the individualized and accurate medical treatment of mental diseases can be realized.
According to a first aspect of the present application, a magnetic resonance imaging system integrating neuromodulation is provided. Comprising the following steps: a frame comprising a frame bottom for positioning beside the head mount, a frame top above the frame bottom, and a frame side connected between the frame bottom and the frame top, the frame bottom, the frame top, and the frame side defining a head receiving area having one open end outside of which is a shoulder placement area and the other open end forming a first stimulation device mounting area, the frame top having a second stimulation device mounting area disposed thereon; the head magnetic resonance radio frequency coil comprises a flexible wearable base and a radio frequency coil arranged in the flexible wearable base, the head magnetic resonance radio frequency coil is also respectively provided with a sight hole and an equipment abdication area, when the head magnetic resonance radio frequency coil is worn on the head of a tested person, the equipment abdication area provides a first channel for exposing a specific part of the head of the tested person, and the sight hole provides a second channel for the tested person to observe outwards; the stimulation device comprises a first stimulation device and a second stimulation device, the first stimulation device and the second stimulation device are respectively arranged in the first device installation area and the second device installation area at the same time or in a time-sharing mode, the first stimulation device is electromagnetic stimulation device and acts on a tested person through the first channel, and the second stimulation device is visual stimulation device and acts on the tested person through the second channel.
Optionally, the first stimulation device comprises: transcranial magnetic stimulation Transcranial Magnetic Stimulation equipment, TMS equipment for short; and/or transcranial direct current stimulation transcranial Direct Current Stimulation equipment, abbreviated as tDCS equipment; and/or a focused ultrasound interventional therapy MR guide Focused Ultrasound device, abbreviated as MRgFUS device, under magnetic resonance guidance. Optionally, the visual stimulus device includes a Virtual Reality real Reality device, abbreviated as VR device.
Optionally, the head magnetic resonance radio frequency coil is a band-shaped body when being unfolded and is worn on the head of the subject in a cylindrical structure which can wrap the head of the subject and is rolled along the long side of the band-shaped body.
Alternatively, the two ends of the length of the band-shaped body are provided with adhesive structures which can be adhered to each other and can adjust the inner diameter of the cylindrical structure by changing the adhesive positions so as to adjust the wearing tightness of the cylindrical structure.
Optionally, a convex face-attachable lining is arranged on the inner side of the head magnetic resonance radio frequency coil; or, a protruding face-fitting lining is arranged on the inner side of the head magnetic resonance radio frequency coil, the lining comprises an eye socket fitting part, a groove with the edge arranged along the periphery of the eye socket is formed in the eye socket fitting part, and the second channel is positioned in the groove; or, a protruding face-fitting lining is arranged on the inner side of the head magnetic resonance radio frequency coil, the lining comprises an eye socket fitting part, the eye socket fitting part is provided with a groove with edges arranged along the periphery of the eye socket, the groove is a flat annular groove which covers the two eye sockets at the same time, and the second channel is positioned in the groove; or, a protruding face-fitting lining is arranged on the inner side of the head magnetic resonance radio frequency coil, the lining comprises an eye socket fitting part, the eye socket fitting part is provided with a nose bridge transverse supporting part, and the nose bridge transverse supporting part is provided with an arc-shaped structure with thin middle and thick two ends in the thickness direction; or, a protruding face-fitting lining is arranged on the inner side of the magnetic resonance radio frequency coil of the head, and the lining comprises an eye orbit fitting part and a forehead fitting part; or, the inside of the magnetic resonance radio frequency coil of the head is provided with a protruding face-fitting lining, the lining comprises an eye socket fitting part and a forehead fitting part, and the forehead fitting part is obliquely arranged so as to extend in the forehead width direction and the forehead height direction simultaneously.
According to a second aspect of the present application, there is provided a head magnetic resonance radio frequency coil for magnetic resonance imaging, comprising a flexible wearable base and a radio frequency coil disposed in the flexible wearable base, the head magnetic resonance radio frequency coil being further provided with a viewing aperture and a device yield zone, respectively, the device yield zone providing a first channel exposing a specific part of the head of a subject when the head magnetic resonance radio frequency coil is worn on the head of the subject, the viewing aperture providing a second channel for the subject to look outwards.
Alternatively, the two ends of the length of the band-shaped body are provided with adhesive structures which can be adhered to each other and can adjust the inner diameter of the cylindrical structure by changing the adhesive positions so as to adjust the wearing tightness of the cylindrical structure.
Optionally, a convex face-attachable lining is arranged on the inner side of the head magnetic resonance radio frequency coil; or, a protruding face-fitting lining is arranged on the inner side of the head magnetic resonance radio frequency coil, the lining comprises an eye socket fitting part, a groove with the edge arranged along the periphery of the eye socket is formed in the eye socket fitting part, and the second channel is positioned in the groove; or, a protruding face-fitting lining is arranged on the inner side of the head magnetic resonance radio frequency coil, the lining comprises an eye socket fitting part, the eye socket fitting part is provided with a groove with edges arranged along the periphery of the eye socket, the groove is a flat annular groove which covers the two eye sockets at the same time, and the second channel is positioned in the groove; or, a protruding face-fitting lining is arranged on the inner side of the head magnetic resonance radio frequency coil, the lining comprises an eye socket fitting part, the eye socket fitting part is provided with a nose bridge transverse supporting part, and the nose bridge transverse supporting part is provided with an arc-shaped structure with thin middle and thick two ends in the thickness direction; or, a protruding face-fitting lining is arranged on the inner side of the magnetic resonance radio frequency coil of the head, and the lining comprises an eye orbit fitting part and a forehead fitting part; or, the inside of the magnetic resonance radio frequency coil of the head is provided with a protruding face-fitting lining, the lining comprises an eye socket fitting part and a forehead fitting part, and the forehead fitting part is obliquely arranged so as to extend in the forehead width direction and the forehead height direction simultaneously.
According to a third aspect of the present application there is provided a magnetic resonance imaging method integrating neuromodulation, in which the system of the first aspect is used, the magnetic resonance imaging is performed by at least one of the first and second stimulation devices acting on the subject simultaneously or time-division.
The system and the method for magnetic resonance imaging can be used for magnetic resonance imaging by combining brain function intervention regulation and control means for generating a physical field by electromagnetic stimulation equipment on the basis of traditional function magnetic resonance imaging. Therefore, the limitations of the traditional functional magnetic resonance imaging in visual stimulation can be broken through, and the brain functional intervention regulation means of the physical field generated by the electromagnetic stimulation equipment can be changed from a passive positioning treatment means to a functional magnetic resonance imaging stimulation means. Through fMRI scanning under electromagnetic stimulation, the mode of change of the nerve loop function of each individual can be revealed, and then an individualized functional target point is defined, so that individualized and accurate medical treatment of mental diseases is realized. The system for magnetic resonance imaging and the head magnetic resonance radio frequency coil are simple and reasonable in structural design, and different stimulation devices can be combined skillfully on the basis of utilizing the existing magnetic resonance imaging device.
The application is further described below with reference to the drawings and detailed description. Additional aspects and advantages of the application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the application.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the application and, together with the description, serve to explain the principles of the application. In the drawings:
fig. 1 is a schematic diagram of a system for magnetic resonance imaging according to an embodiment of the present application.
Fig. 2 is a schematic view of the product of fig. 1 at another angle.
Fig. 3 is a schematic structural diagram of a magnetic resonance rf coil for a head according to an embodiment of the present application.
Fig. 4 is a schematic view of the product of fig. 3 in a perspective state.
Detailed Description
The present application will now be described more fully hereinafter with reference to the accompanying drawings. Those skilled in the art will be able to implement the solution of the application based on these descriptions. Before describing the present application with reference to the accompanying drawings, it should be noted in particular that:
the technical solutions and technical features provided in the respective sections including the following description in the present specification may be combined with each other without conflict.
The matter set forth in the following description will generally be presented to illustrate only some, but not all embodiments of the application and, accordingly, will be apparent to those of ordinary skill in the art from consideration of the specification and practice of the application.
The terms "comprising," "including," "having," and any variations thereof, in the present specification and claims, and in the related sections, are intended to cover a non-exclusive inclusion.
Fig. 1 is a schematic diagram of a system for magnetic resonance imaging according to an embodiment of the present application in fig. 1. Fig. 2 is a schematic view of the product of fig. 1 at another angle. Fig. 3 is a schematic structural diagram of a magnetic resonance rf coil for a head according to an embodiment of the present application. Fig. 4 is a schematic view of the product of fig. 3 in a perspective state. As shown in fig. 1-4, a system for magnetic resonance imaging, comprising: a frame 10, a head magnetic resonance radio frequency coil 20 and a stimulation device 30. Wherein the frame 10 comprises a frame bottom 11 for positioning beside a head rest (i.e. headrest, which is part of the existing magnetic resonance imaging apparatus), a frame top 12 above the frame bottom 11, and a frame side 13 connected between the frame bottom 11 and the frame top 12, the frame bottom 11, the frame top 12, and the frame side 13 defining a head receiving area 14, one end of the head receiving area 14 being open outside of a shoulder placement area 15 of the subject 40 and the other end being open to form a first stimulation apparatus mounting area 16, the frame top 12 being provided with a second stimulation apparatus mounting area 17; the head magnetic resonance rf coil 20 comprises a flexible wearable base 21 (which may be made of EVA material, i.e. ethylene-vinyl acetate copolymer material) and an rf coil 22 disposed in the flexible wearable base 21, wherein the head magnetic resonance rf coil 20 is further provided with a viewing hole 23 and an equipment abdication area 24, respectively, when the head magnetic resonance rf coil 20 is worn on the head of the subject 40, the equipment abdication area 24 provides a first channel exposing a specific portion of the head of the subject 40, and the viewing hole 23 provides a second channel for the subject to observe outwards; the stimulation device 30 comprises a first stimulation device 31 and a second stimulation device 32, the first stimulation device 31 and the second stimulation device 32 are respectively installed in the first device installation area 16 and the second device installation area 17 at the same time or in a time sharing mode, the first stimulation device 31 is an electromagnetic stimulation device and acts on the tested person 40 through the first channel, and the second stimulation device 32 is a visual stimulation device and acts on the tested person 40 through the second channel.
The first stimulation device may be at least one or more of transcranial magnetic stimulation Transcranial Magnetic Stimulation device (TMS device for short), transcranial direct current stimulation transcranial Direct Current Stimulation device (tDCS device for short) and focused ultrasound interventional therapy MR guide Focused Ultrasound device (MRgFUS device for short) under magnetic resonance guidance. The second stimulation device may be a Virtual Reality (VR) device. TMS equipment, tDCS equipment, MRgFUS equipment and VR equipment are all prior art. Wherein, the TMS device and the TDCS device both use pulse magnetic field or weak direct current to act on the brain, and change the membrane potential of cortical nerve cells to influence the metabolism and the nerve electrical activity in the brain, thereby causing a series of physiological and biochemical reactions. The TMS device generates an induced magnetic field by pulsed current in the coil, passes through the skull, generates a reverse induced current in the brain, and the current in the cortex can activate neurons and cause microscopic changes in axons, further causing changes in electrophysiology and function. the tDCS device functions by modulating the activity of spontaneous neuronal networks; at the neuronal level, the basic mechanism of regulating cortical excitability is to induce hyperpolarization or depolarization change of resting membrane potential according to the polarity of stimulation, and at the same time, the micro-environment of synapses can be regulated, such as changing the activity of NMDA receptors or GABA, so as to play a role in regulating synaptic plasticity. Along with the accumulation of clinical evidence, neural regulation and control technologies such as TMS equipment, tDCS equipment and the like are gradually evolved into regulation and control treatment means of diseases. The MRgFUS device is a newer non-ionizing radiation and non-invasive precise noninvasive regulation and control technology, and the intervention treatment mode utilizes the mechanical effect (the change of sound intensity and frequency) of ultrasonic waves to activate or inhibit nerve cells, and has the characteristics of precise positioning, small action area, high targeting, good multi-parameter regulation and control performance, capability of stimulating intracranial deep tissues and the like, the action range of focused ultrasound can be precisely up to a micron-sized pressure, and the intervention on deep parts of human brain tissues can be realized. Overall, MRgFUS devices can achieve more accurate and effective brain function intervention regulation than TMS devices or tDCS devices.
It has also been found from the above description that the TMS device and/or the TDCS device act mainly on the superficial brain structures and the MRgFUS device acts mainly on the deep brain structures, and thus, when the first stimulation apparatus comprises the TMS device and/or the TDCS device in combination with the MRgFUS device, a more comprehensive transcranial stimulation need may be met.
The main characteristics of the system structure for magnetic resonance imaging are as follows: the application provides a head magnetic resonance radio frequency coil 20 which is wearable in nature, a sight hole 23 and a device yielding zone 24 are designed on the head magnetic resonance radio frequency coil 20, on the basis, a frame 10 is externally arranged on the head magnetic resonance radio frequency coil 20 and is used for providing a first stimulation device mounting zone 16 and a second stimulation device mounting zone 17, when the first stimulation device 31 and the second stimulation device 32 are simultaneously or time-sharing respectively arranged on the first device mounting zone 16 and the second device mounting zone 17, the first stimulation device 31 acts on a tested person 40 through the device yielding zone 24, and the second stimulation device 32 acts on the tested person 40 through the sight hole 23. The main advantage of the characteristics is that the whole system has extremely optimized utilization of space, and the occupied space of the whole system can be extremely small, so that the system can be directly added in the channel of the existing magnetic resonance imaging equipment.
As a preferred embodiment of the head mr rf coil 20, as shown in fig. 1-4, the head mr rf coil 20 is a band-shaped body when deployed and is worn on the head of the subject 40 in a cylindrical configuration wrapped around the head of the subject by being rolled along the long sides of the band-shaped body. In addition, the two ends of the length of the band may be provided with an adhesive structure 25 (such as a velcro) that can be adhered to each other and can adjust the inner diameter of the cylindrical structure by changing the adhesive position to thereby adjust the wearing tightness of the cylindrical structure. The cylindrical structure has an advantage in that the end thereof is opened to expose the entire head top of the subject 40, so that the first stimulation device 31 can cover both the head top of the subject 40 and the side surface and even the bottom surface of the head of the subject 40 from the gap between the head of the subject 40 and the cylindrical structure, which can be changed by adjusting the wearing tightness of the cylindrical structure.
In addition, as shown in fig. 3-4, the inner side of the head mr coil 20 is further provided with a convex-shaped face-conformable liner 26. The inner liner 26 can help the head mr coil 20 to be worn and positioned, so that a gap is reserved between the head mr coil 20 and the head of the subject 40 after being worn, and the wearing comfort of the head mr coil 20 is improved. The inner liner 26 may be made of a soft, skin friendly material. To make the design of the liner 26 more reasonable, the liner 26 may include an orbit fit portion 261, where the orbit fit portion 261 is provided with a groove 262 that is arranged along the orbit circumference, and the second channel is located in the groove 262; the recess 262 is preferably a flat annular recess that simultaneously covers both eyepieces. Optionally, the orbit fitting portion 261 has a bridge lateral support portion 264, and the bridge lateral support portion 264 has an arc structure with thin middle and thick ends in the thickness direction. Optionally, liner 26 further includes an orbital and forehead abutment 263; the forehead attaching part 263 is preferably provided obliquely so as to extend in both the forehead width direction and the forehead height direction.
In the case of using the above system for magnetic resonance imaging, the method for magnetic resonance imaging according to the embodiment of the present application applies at least one stimulation means (when the first stimulation device 31 includes at least two devices, at least one of the at least two devices) of the first stimulation device 31 and the second stimulation device 32 to the subject simultaneously or time-division and performs magnetic resonance imaging. Specifically, the VR device and the MRgFUS device may operate simultaneously, and the VR device and the TMS device or the tDCS device may operate simultaneously.
One of ordinary skill in the art will be able to implement embodiments of the present application based on the above description. Based on the foregoing provided herein, all other embodiments that would be apparent to one of ordinary skill in the art without making any inventive effort are intended to be within the scope of the present application.
Claims (5)
1. A magnetic resonance imaging system integrating neuromodulation, comprising:
a frame comprising a frame bottom for positioning beside the head mount, a frame top above the frame bottom, and a frame side connected between the frame bottom and the frame top, the frame bottom, the frame top, and the frame side defining a head receiving area having one open end outside of which is a shoulder placement area and the other open end forming a first stimulation device mounting area, the frame top having a second stimulation device mounting area disposed thereon;
the head magnetic resonance radio frequency coil comprises a flexible wearable base and a radio frequency coil arranged in the flexible wearable base, the head magnetic resonance radio frequency coil is also respectively provided with a sight hole and an equipment abdication area, when the head magnetic resonance radio frequency coil is worn on the head of a tested person, the equipment abdication area provides a first channel for exposing a specific part of the head of the tested person, and the sight hole provides a second channel for the tested person to observe outwards; the head magnetic resonance radio frequency coil is a strip-shaped body when being unfolded and is worn on the head of a tested person in a cylindrical structure which is rolled along the long side of the strip-shaped body and can wrap the head of the tested person;
the stimulation device comprises a first stimulation device and a second stimulation device, the first stimulation device and the second stimulation device are respectively arranged in the first stimulation device installation area and the second stimulation device installation area at the same time or in a time-sharing mode, the first stimulation device is electromagnetic stimulation device and acts on a tested person through the first channel, and the second stimulation device is visual stimulation device and acts on the tested person through the second channel;
the first stimulation device comprises: transcranial magnetic stimulation Transcranial Magnetic Stimulation equipment, TMS equipment for short; and/or transcranial direct current stimulation transcranial Direct Current Stimulation equipment, abbreviated as tDCS equipment; and/or a focused ultrasound interventional therapy MR guide Focused Ultrasound device, abbreviated as MRgFUS device, under magnetic resonance guidance.
2. The system of claim 1, wherein: the visual stimulus device comprises a Virtual Reality (VR) device for short.
3. The system of claim 1, wherein: the two ends of the length of the band-shaped body are provided with adhesive structures which can be adhered to each other and can adjust the wearing tightness of the cylindrical structure by changing the adhesive positions to adjust the inner diameter of the cylindrical structure.
4. The system of claim 1, wherein: the inner side of the head magnetic resonance radio frequency coil is provided with a convex face-attachable lining;
or, a protruding face-fitting lining is arranged on the inner side of the head magnetic resonance radio frequency coil, the lining comprises an eye socket fitting part, a groove with the edge arranged along the periphery of the eye socket is formed in the eye socket fitting part, and the second channel is positioned in the groove;
or, a protruding face-fitting lining is arranged on the inner side of the head magnetic resonance radio frequency coil, the lining comprises an eye socket fitting part, the eye socket fitting part is provided with a groove with edges arranged along the periphery of the eye socket, the groove is a flat annular groove which covers the two eye sockets at the same time, and the second channel is positioned in the groove;
or, a protruding face-fitting lining is arranged on the inner side of the head magnetic resonance radio frequency coil, the lining comprises an eye socket fitting part, the eye socket fitting part is provided with a nose bridge transverse supporting part, and the nose bridge transverse supporting part is provided with an arc-shaped structure with thin middle and thick two ends in the thickness direction;
or, a protruding face-fitting lining is arranged on the inner side of the magnetic resonance radio frequency coil of the head, and the lining comprises an eye orbit fitting part and a forehead fitting part;
or, the inside of the magnetic resonance radio frequency coil of the head is provided with a protruding face-fitting lining, the lining comprises an eye socket fitting part and a forehead fitting part, and the forehead fitting part is obliquely arranged so as to extend in the forehead width direction and the forehead height direction simultaneously.
5. A magnetic resonance imaging method integrating neuromodulation, characterized in that: use of a system according to any of claims 1-4 for simultaneous or time-shared application and magnetic resonance imaging of a subject by at least one stimulation means of the first stimulation device and the second stimulation device.
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