CN114200123A

CN114200123A - Chemiluminescence immunity analyzer

Info

Publication number: CN114200123A
Application number: CN202111486740.7A
Authority: CN
Inventors: 叶翔; 谭运攀
Original assignee: Shenzhen Shixin Medical Technology Co ltd
Current assignee: Shenzhen Shixin Medical Technology Co ltd
Priority date: 2021-12-07
Filing date: 2021-12-07
Publication date: 2022-03-18

Abstract

The utility model belongs to the technical field of check out test set, provide chemiluminescence immunoassay appearance, set up the control system in the frame including the frame, and set up in the frame and feed transfer system with control system electric connection's reaction cup respectively, mixing system, collection system, incubate cleaning system and photometry system, reaction cup feeds transfer system and is used for depositing, feeds and carries the reaction cup, collection system is used for moving the intraductal reagent of sample and reagent with the sample in the sample pipe to mixing position, and gather the information of sample pipe and reagent pipe, mixing system is used for the material in the mixing reaction cup, incubate cleaning system and be used for incubating, washing, add substrate and mixing operation to the material in the reaction cup, photometry system is used for right through the above-mentioned material of incubating, washing, adding the reaction cup after substrate and mixing operation carries out optical detection. The chemiluminescence immunoassay analyzer has high automation degree, and can avoid the influence of human factors on the accuracy and reliability of detection as much as possible.

Description

Chemiluminescence immunity analyzer

Technical Field

The application relates to the technical field of detection equipment, in particular to a chemiluminescence immunoassay analyzer.

Background

Chemiluminescence immunoassay is a novel ultramicroanalytical technique combining chemiluminescence assay technology with high sensitivity and high specificity immunoreaction.

At present, most of chemiluminescence immune analyzers in the industry adopt a mode of manual test operation and semi-automatic detection, detection instruments only achieve a detection reading function, uncertainty such as individual difference, manual error and nonstandard operation exists in manual operation, defects are exposed under the condition that the number of samples and test items are numerous, the problem of low automation degree exists, and the accuracy and reliability of detection are affected.

Disclosure of Invention

An object of the embodiment of the present application is to provide a chemiluminescence immunoassay analyzer to solve the technical problems that the degree of automation of chemiluminescence immunoassay analyzers in the prior art is low, and the accuracy and reliability of detection are affected.

In order to achieve the purpose, the technical scheme adopted by the application is as follows: the chemiluminescence immunoassay analyzer comprises a rack, and a reaction cup feeding and conveying system, a blending system, an acquisition system, an incubation and cleaning system, a photometric system and a control system which are arranged on the rack;

the reaction cup feeding and conveying system comprises a cup feeding mechanism for storing and feeding reaction cups and a conveying mechanism which is movably arranged on the rack and is used for conveying the reaction cups;

the blending system is provided with a blending position and is used for blending the substances in the reaction cup in the blending position;

the collecting system comprises a sample introduction mechanism, a transfer mechanism, a rotating mechanism, a first information collecting mechanism, a second information collecting mechanism, a reagent tube mixing mechanism and a sample collecting mechanism, wherein the sample introduction mechanism is used for storing and dispatching a sample tube and is provided with a sample sucking position and an information collecting position;

the incubation and cleaning system is used for performing incubation operation on the substances in the reaction cups uniformly mixed by the uniformly mixing system, and is used for performing cleaning operation, substrate filling operation and uniformly mixing operation on the substances in the reaction cups subjected to the incubation operation;

the photometric system comprises a photometric mechanism which is arranged on one side of the incubation and cleaning system and is used for optically detecting substances in the reaction cup passing through the incubation and cleaning system;

the control system respectively with reaction cup feed conveying system, mixing system, the collection system incubate cleaning system and photometry system electric connection.

In one embodiment, the transfer mechanism includes a sample needle, a sample arm, a sample adding driver, a reagent needle, a reagent arm, and a reagent adding driver, the sample needle is disposed at one end of the sample arm, the sample adding driver is configured to drive the sample arm to move so as to move the sample needle to the sample sucking position or the mixing position, the reagent needle is disposed at one end of the reagent arm, and the reagent adding driver is configured to drive the reagent arm to move so as to move the reagent needle to the reagent sucking position or the mixing position.

In one embodiment, the transfer mechanism further includes a first washer for washing the sample needle and a second washer for washing the reagent needle.

In one embodiment, the rotating mechanism comprises a first shaft, a second shaft, a rotating wheel, a prepressing arm, two prepressing wheels and a position adjusting assembly, wherein the first shaft and the second shaft are arranged on two sides of the information acquisition position; the rotating wheel is rotatably arranged on the first shaft and is used for abutting against the outer surface of the sample tube positioned at the information acquisition position so as to rotate the sample tube; the pre-pressing arm is rotatably sleeved on the second shaft, the two pre-pressing wheels are arranged on the pre-pressing arm, and the position adjusting assembly is used for applying elastic force to the pre-pressing arm so that the pre-pressing arm drives the two pre-pressing wheels to elastically press the outer surface of the sample tube located at the information acquisition position.

In one embodiment, the position adjusting assembly comprises a mounting seat, a guide rod and an elastic piece, the mounting seat is provided with the second shaft, and the mounting seat is also provided with a first limiting surface; the first end of the pre-pressing arm is connected with two pre-pressing wheels, and the second end of the pre-pressing arm is provided with a sliding groove; the first end of the guide rod is in sliding fit with the sliding groove, and the second end of the guide rod is fixed on the mounting seat; the elastic piece is sleeved on the guide rod and abutted between the mounting seat and the pre-pressing arm, and after the sample tube leaves the information acquisition position, the pre-pressing arm is abutted to the first limiting surface under the action of the elastic piece.

In one of them embodiment, incubate cleaning system includes the pot body, washs the dish, incubate the driver, wash the driver and wash the module, the pot body set up in the frame, incubate the dish with wash the dish set up coaxially in the pot body, it is located to incubate the dish the top just the internal diameter of wasing the dish is less than wash the internal diameter of dish, the upper portion of incubating the dish is equipped with and is used for the holding the groove of incubating of reaction cup, it surpasss to wash the dish the position of incubating the dish is equipped with and is used for the holding the washing tank of reaction cup, it is used for the drive to incubate the driver it is rotatory to incubate the dish, wash the driver and be used for the drive wash on the dish reaction cup extremely wash the module and carry out cleaning operation, mixing operation and substrate filling operation.

In one embodiment, the cleaning module comprises a first lifting plate, a plurality of liquid suction needles and a second lifting plate which are arranged on the first lifting plate along the circumferential direction of the first lifting plate, and liquid injection needles which are arranged on the second lifting plate along the circumferential direction of the second lifting plate and are the same in number with the liquid suction needles, wherein the liquid suction needles and the liquid injection needles are alternately arranged, the liquid suction needles are arranged below the liquid suction needles, the liquid injection needles are arranged below the liquid injection needles, and the cleaning disc drives the reaction cups to suck liquid from the liquid suction needles and drive the reaction cups to inject liquid from the liquid injection needles when rotating.

In one embodiment, the incubation and cleaning system further comprises two substrate liquid filling pipes, wherein the two substrate liquid filling pipes are respectively used for filling substrate liquid required by direct chemiluminescence and substrate liquid required by enzymatic reaction chemiluminescence into the reaction cup subjected to cleaning operation.

In one embodiment, the photometric mechanism comprises a dark box, a shading driver, a shading assembly and a photomultiplier tube, wherein the dark box is provided with an accommodating cavity, a first light hole and a second light hole which are oppositely arranged are arranged on the cavity wall of the accommodating cavity, the shading driver is arranged on the dark box, and one end of an output shaft of the shading driver is placed into the accommodating cavity; the photomultiplier install in first light trap department and pass through light signal is received to first light trap, the shading subassembly set up in the inside in holding chamber, the shading subassembly includes shading arm and swing arm, be equipped with the locating pin on the chamber wall in holding chamber, the shading arm rotationally overlaps and locates on the locating pin, the one end of swing arm connect in the output shaft of shading driver, just the other end of swing arm is used for driving the shading arm is rotatory, so that the shading arm shelters from the second light trap or follows second light trap department puts aside.

In one embodiment, the sample injection mechanism comprises an emergency sample tube support and an emergency driver, the sample injection mechanism further comprises an emergency position, the emergency position is located on the motion track of the transfer mechanism, an emergency sample tube slot for accommodating an emergency sample tube is arranged on the emergency sample tube support, and the emergency driver is used for driving the emergency sample tube support to move on the rack, so that the emergency sample tube on the emergency sample tube enters or leaves the emergency position.

In one embodiment, the sampling mechanism further includes a sample tube holder and a sampling driver, the information acquisition position is located on the sampling side of the sample suction position, the sample tube holder has a plurality of sample tube slots for accommodating the sample tubes, and the sampling driver is configured to drive the sample tube holder to move on the rack, so that each sample tube on the sample tube holder sequentially passes through the sample suction position and each sample tube sequentially passes through the information acquisition position.

In one embodiment, the cup feeding mechanism comprises a load storage part arranged on the rack and used for loading and storing the reaction cups, a conveying part arranged on one side of the load storage part and butted with the load storage part, and a rotating disc butted with the conveying part.

In one embodiment, the chemiluminescent immunoassay analyzer further comprises a cup throwing system comprising a waste liquid recovery mechanism for recovering substances in the used reaction cups and a waste cup recovery mechanism for recovering the used reaction cups.

The chemiluminescence immunoassay analyzer has the beneficial effects that: compared with the prior art, in the chemiluminescence immunoassay analyzer provided by the embodiment, the carrying mechanism in the reaction cup feeding and conveying system carries the reaction cups fed by the cup feeding mechanism to the mixing position of the mixing system, the first information collecting mechanism of the collecting system automatically collects information of the sample tubes at the information collecting position, the second information collecting mechanism collects information of the reagent tubes in the reagent disk mechanism, automatically transfers the samples in the sample tubes on the sample sucking position of the sample feeding mechanism and the reagents on the reagent sucking position of the reagent disk mechanism to the reaction cups on the mixing position, the mixing system mixes the samples and the reagents in the reaction cups on the mixing position, the carrying mechanism carries the reaction cups on the mixing position to the incubation cleaning system, the incubation cleaning system automatically completes incubation operation, cleaning operation, substrate filling operation and mixing operation (when the reaction cups need to be transported back to the mixing system again for mixing operation, carry the blending operation with reaction cup back blending position by transport mechanism), when the reaction cup that incubate among the cleaning system rotated to the position of aiming at with photometry system, photometry system carried out optical detection to the interior material of reaction cup, and then made whole analysis operation full automation, can avoid the accuracy and the reliability that the human factor influence detected as far as possible.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the embodiments or the prior art descriptions will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive exercise.

Fig. 1 is a schematic top view of a chemiluminescent immunoassay analyzer provided in an embodiment of the present application;

FIG. 2 is a schematic structural diagram of a chemiluminescence immunoassay analyzer provided in an embodiment of the present application;

FIG. 3 is a schematic structural diagram of a reagent disk mechanism provided in an embodiment of the present application;

fig. 4 is a schematic structural diagram of a sample injection mechanism, a rotation mechanism, and a first information acquisition mechanism provided in the embodiment of the present application;

fig. 5 is a schematic top view of an incubation and cleaning system provided in an embodiment of the present application;

FIG. 6 is a cross-sectional view taken along line A-A of the incubation washing system shown in FIG. 5 with the photometric system removed;

fig. 7 is a schematic partial structural view of a rotating mechanism provided in an embodiment of the present application;

fig. 8 is a schematic top view of the rotary mechanism shown in fig. 7;

fig. 9 is a schematic structural diagram of a photometry system according to an embodiment of the present application;

FIG. 10 is a cross-sectional view of the light metering system shown in FIG. 9;

FIG. 11 is a schematic view of a test flow of a chemiluminescent immunoassay analyzer provided in an embodiment of the present application;

wherein, in the figures, the respective reference numerals:

100-a frame;

200-a reaction cup feed conveyor system; 210-a cup feeding mechanism; e-cup entering position; 211-load store; 212-a transfer section; 213-rotating the disc; 220-a handling mechanism;

300-a blending system; a-mixing position;

400-an acquisition system; 410-a sample introduction mechanism; b-suction of sample position; c-information acquisition bits; f-emergency position; 411-sample tube holder; 412-sample injection driver; 413-sample pre-detection placement area; 414-sample introduction track; 415-post-sample detection placement area; 416-emergency sample tube holder; 417-emergency drivers; 420-a reagent disk mechanism; d-sucking the reagent site; 421-reagent tray; 4211-pinion; 422-reagent pot; 423-reagent disk drive; 424-rotating means; 4241-bull gear; 430-a transfer mechanism; 431-a sample needle; 432-sample arm; 433-sample application driver; 434-reagent needle; 435-reagent arm; 436-reagent addition drive; 437-first washer; 438-second washer; 440-a rotation mechanism; 441-first axis; 442-a second axis; 443-a rotator wheel; 444-pre-pressing wheel; 445-pre-press arm; 4451-a chute; 4452-grooves; 446 — a position adjustment assembly; 4461-a mounting seat; 4462-a guide bar; 4463-an elastic member; 4464-a first limiting surface; 4465-a substrate; 4466-a platen; 4467-a second limiting surface; 4468-a regulating wheel; 450-a first information collection mechanism; 460-a second information collection mechanism;

500-incubation washing system; g-incubation position; h-a cleaning station; i-liquid absorption level; j-fill level; k-taking a cup position from the waste cup; 510-a pot body; 511-pot bottom; 512-a cover body; 513-mounting holes; 520-a washing disc; 530-incubation plate; 540-incubation drive; 550-cleaning the driver; 560-a cleaning module; 561-a first lifter plate; 562-a pipette needle; 563-a second lifter plate; 564-a liquid injection needle; 570-a rotating shaft; 580-rotating sleeve; 590-substrate liquid filling tube;

600-a photometric system; 610-dark box; 611-a containing cavity; 612-a first light-transmitting aperture; 613-second light-transmitting hole; 614-locating pins; 620-shading driver; 630-a shade assembly; 631-a shutter arm; 632-swing arm; 640-a photomultiplier tube;

700-a control system;

800-a cup throwing system; 810-a waste liquid recovery mechanism; 820-a used cup recovery mechanism; m-cup throwing position.

Detailed Description

Reference will now be made in detail to embodiments of the present application, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary and intended to be used for explaining the present application and should not be construed as limiting the present application.

In the description of the present application, it is to be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like, as used herein, refer to an orientation or positional relationship indicated in the drawings, which is for convenience and simplicity of description, and does not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus, is not to be considered as limiting.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless specifically limited otherwise.

Referring to fig. 1, a chemiluminescent immunoassay analyzer provided in the examples of the present application will now be described. The chemiluminescence immunoassay analyzer is mainly used for detecting and analyzing substances such as antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins and medicines, the adopted analysis method is a chemiluminescence immunoassay method, the chemiluminescence immunoassay method is a method combining immunoreaction and chemiluminescence, and mainly comprises direct chemiluminescence analysis and enzymatic chemiluminescence analysis, wherein the direct chemiluminescence analysis refers to an analysis method that a luminescent substance is marked on the substances such as the antigens or the antibodies, after the immunoreaction is finished, corresponding substrate liquid is added into reaction liquid to enable the luminescent substance to emit light, and then the concentration of the antigens or the antibodies is measured by measuring the luminous intensity; enzymatic chemiluminescence analysis refers to an analysis method in which an enzyme is labeled with a substance such as an antigen or an antibody, and after completion of an immunoreaction, a corresponding substrate solution is added to a reaction solution to cause the substrate solution to emit light, and then the concentration of the antigen or the antibody is measured by measuring the intensity of the emitted light.

The chemiluminescence immunoassay analyzer provided by the embodiment comprises a rack 100, a reaction cup feeding and conveying system 200 arranged on the rack 100, a blending system 300, an acquisition system 400, an incubation and cleaning system 500, a photometric system 600 and a control system 700. Wherein the frame 100 is a supporting structure of the whole chemiluminescence immunoassay analyzer, and the control system 700 is electrically connected with the reaction cup feeding and conveying system 200, the blending system 300, the collecting system 400, the incubation system and the photometric system 600 respectively, and is used for controlling the chemiluminescence immunoassay analyzer to automatically perform chemiluminescence immunoassay.

The cuvette feeding and conveying system 200 includes a cuvette feeding mechanism 210 and a carrying mechanism 220, wherein the cuvette feeding mechanism 210 is used for storing and feeding cuvettes, and the carrying mechanism 220 is movably disposed on the frame 100 and is used for carrying cuvettes fed by the cuvette feeding mechanism 210.

The kneading system 300 has a kneading station a and is used for kneading a substance placed in a cuvette at the kneading station a.

The collection system 400 includes a sample introduction mechanism 410, a reagent tray mechanism 420, a transfer mechanism 430, a rotation mechanism 440, a first information collection mechanism 450, and a second information collection mechanism 460. The sample feeding mechanism 410 is used for storing and dispatching sample tubes and is provided with a sample sucking position b and an information collecting position c, the reagent tray mechanism 420 is rotatably arranged on the rack 100 and is used for storing and dispatching reagent tubes and is provided with a reagent sucking position d, the transferring mechanism 430 is movably arranged on the rack 100 and is used for transferring samples in the sample tubes sucking the sample position b and reagents in the reagent tubes sucking the reagent positions d to reaction cups on the mixing position a, the rotating mechanism 440 is used for driving the sample tubes on the information collecting position c to rotate, the first information collecting mechanism 450 is used for collecting information of the sample tubes rotating on the information collecting position c, and the second information collecting mechanism 460 is used for collecting information of the reagent tubes in the reagent tray mechanism 420.

The incubation and cleaning system 500 is used for performing incubation operation on the substances in the reaction cups uniformly mixed by the uniformly mixing system 300, and is used for performing cleaning operation, substrate filling operation and uniformly mixing operation on the substances in the reaction cups after the incubation operation.

The light measuring system 600 is disposed at one side of the incubation and cleaning system 500 for optically detecting substances in the reaction cups passing through the incubation and cleaning system 500.

The control system 700 is electrically connected to the cuvette feeding and conveying system 200, the mixing system 300, the collection system 400, the incubation and cleaning system 500, and the photometric system 600, respectively.

It should be noted that the information of the sample tube may be information such as name of a patient to which the sample belongs, name of a project to be detected, etc., the information of each reagent tube in the reagent tray mechanism 420 may be information such as position information of the reagent tube in the reagent tray 421, name, concentration, volume, etc., the second information collecting mechanism 460 may collect information of each reagent tube placed in the reagent tray mechanism 420 in real time, a plurality of positions for placing the reagent tube are divided in the reagent tray mechanism 420, and when each position for placing the reagent tube can only place a specific reagent corresponding to the position, the second information collecting mechanism 460 may replace the information of the reagent tube by collecting or storing information of the specific reagent that can be placed in each position in the reagent tray mechanism 420, and may be set as needed, which is not limited uniquely, the control system 700 may utilize the information of the reagent tube and the information of the sample tube, the samples are matched with the corresponding reagents.

Compared with the prior art, in the chemiluminescence immunoassay analyzer provided by the embodiment, the carrying mechanism 220 in the cuvette feeding and conveying system 200 carries the cuvette fed by the cuvette feeding mechanism 210 to the mixing position a of the mixing system 300, the first information collecting mechanism 450 of the collecting system 400 collects information of the sample tube at the information collecting position c, the second information collecting mechanism 460 collects information of the reagent tube in the reagent disk mechanism 420, and automatically transfers the sample in the sample tube at the sample suction position b of the sample feeding mechanism 410 and the reagent at the reagent suction position d of the reagent disk mechanism 420 to the cuvette at the mixing position a, the mixing system 300 mixes the sample and the reagent in the cuvette at the mixing position a, the carrying mechanism 220 carries the cuvette at the mixing position a to the incubation and cleaning system 500, the incubation and cleaning system 500 automatically completes incubation operation, cleaning operation, substrate filling operation and mixing operation (when the cuvette needs to be carried back to the mixing system 300 for mixing operation again, carry the reaction cup back to mixing position a by handling mechanism 220 and carry out the mixing operation), when the reaction cup that incubate among the cleaning system 500 is rotatory and the position that photometry system 600 was aimed at, photometry system 600 carries out optical detection to the interior material of reaction cup, and then makes whole analysis operation full automation, can avoid the accuracy and the reliability that the human factor influence detected as far as possible.

In another embodiment of the present application, referring to fig. 3, the reagent tray mechanism 420 includes a reagent tray 421 for carrying reagent tubes, a reagent pan 422 surrounding the reagent tray 421 and capable of refrigerating the reagent tubes carried in the reagent tray 421, a reagent tray driver 423 drivingly connected to the bottom side of the reagent tray 421 for driving the reagent tray to rotate, and a rotating device 424 disposed between the outer pan and the reagent tray 421 for driving the reagent tubes to rotate for mixing.

It should be noted that, magnetic beads are added in the reagent, and the magnetic beads are particles with specific active groups on the surface, uniform size, spherical shape, superparamagnetism and protective shell. The magnetic beads show magnetic force in the presence of an external magnetic field to be gathered, and lose the magnetic force in the absence of the magnetic field to be dispersed. Active substances such as antigen/antibody and the like can be combined with active groups on the surface of the magnetic beads to be coated on the magnetic beads through a certain method, during detection, a to-be-detected object and the magnetic beads coated with the antigen/antibody are incubated under certain conditions, are combined through antigen-antibody reaction, then are subjected to magnetic property by increasing an external magnetic field and are gathered together, namely, cleaning operation can be performed, separation of an antigen-antibody combined part and an unconjugated part is realized, substances such as substrate solution and the like are finally added, a light signal emitted is detected by a light detection system 600, and the content of the antigen/antibody in the to-be-detected object can be analyzed. The rotating device 424 provided by this embodiment is used to uniformly distribute magnetic beads in the reagent, so as to ensure the performance of the magnetic bead reagent.

Specifically, the rotating device 424 may be a large gear 4241, the large gear 4241 is fixed in the reagent pot 422, the reagent disk driver 423 is arranged at the bottom of the reagent pot 422, the reagent disk 421 is fixedly sleeved on an output shaft of the reagent disk driver 423 and coaxially arranged with the large gear 4241, a plurality of small gears 4211 are arranged on the reagent disk 421 along the circumferential direction of the reagent disk 421, the small gears 4211 can be meshed with the large gear 4241, and the reagent tube is fixedly arranged at the upper portion of the small gears 4211, so that when the reagent disk driver 423 drives the reagent disk 421 to rotate, the small gears 4211 can also rotate, and further reagents in the reagent tube can be uniformly mixed.

In another embodiment of the present application, referring to fig. 2, the cup feeding mechanism 210 includes a load storage portion 211 disposed on the rack 100 for loading and storing reaction cups, a transfer portion 212 disposed at one side of the load storage portion 211 and interfacing with the load storage portion 211, and a rotating disk 213 interfacing with the transfer portion 212.

The sample feeding mechanism 410 has a cup feeding position e (see fig. 1), the cuvette conveying unit 212 of the cup feeding mechanism 210 feeds the cuvettes in the load storage unit 211 to the rotating disc 213, the rotating disc 213 transports the cuvettes to the cup feeding position e, and the transporting mechanism 220 transports the newly fed cuvettes from the cup feeding position e to the mixing position a of the mixing system 300.

In another embodiment of the present application, referring to fig. 4, the sample injection mechanism 410 includes a sample tube holder 411 and a sample injection driver 412 (refer to fig. 2), the information collection site c is located on the sample injection side of the sample suction site b (the direction indicated by the arrow in fig. 4 is the sample injection direction), the sample tube holder 411 has a plurality of sample tube slots for accommodating sample tubes, and the sample injection driver 412 is configured to drive the sample tube holder 411 to move on the rack 100, so that the sample tubes on the sample tube holder 411 sequentially pass through the sample suction site b and sequentially pass through the information collection site c.

In the chemiluminescence immunoassay analyzer provided by this embodiment, during detection, the first information collecting mechanism 450 collects information of a sample tube and sends the collected information of the sample tube to the control system 700, the control system 700 controls the sample introduction mechanism 410 to dispatch the sample tube to the sample suction position b, controls the transfer mechanism 430 of the collecting system 400 to transfer the sample in the sample tube on the sample suction position b to the reaction cup of the mixing position a, then controls the reagent tray mechanism 420 to dispatch a reagent tube matched with the sample tube information to the reagent suction position d, controls the transfer mechanism 430 of the collecting system 400 to transfer the reagent in the reagent tube on the reagent suction position d to the mixing position a of the mixing system 300, and can automatically match a proper reagent for the sample.

Optionally, the sample injection mechanism 410 has a sample pre-detection placement region 413, a sample injection rail 414, and a sample post-detection placement region 415, the sample pre-detection placement region 413 and the sample post-detection placement region 415 are disposed opposite and spaced apart, and the sample injection rail 414 connects the two regions and is located on the same side of the two regions. Place the region 413 before the sample detects and place the region 415 after the sample detects and all can place a plurality of rows of sample tube support 411 that are on a parallel with the introduction direction, advance the sample driver 412 along the direction of perpendicular to introduction direction with the sample before the sample detects place the sample tube support 411 in the region 413 and wholly remove to advance the appearance track 414, and advance the appearance track 414 and drive the sample tube support 411 and move the distance of a sample tube at every turn along the introduction direction, after the sample tube on the sample tube support 411 finishes detecting, place the region 415 after the direction of perpendicular to introduction direction with sample tube support 411 bodily movement to the sample detects, be favorable to detecting the sample in an orderly manner.

In another embodiment of the present application, referring to fig. 1 and fig. 4, the sample injection mechanism 410 further includes an emergency sample tube holder 416 and an emergency drive 417, the sample injection mechanism 410 further has an emergency position f located on the moving track of the transfer mechanism 430, the emergency sample tube holder 416 is provided with an emergency sample tube slot for accommodating an emergency sample tube, and the emergency drive 417 is configured to drive the emergency sample tube holder to move on the rack 100 to enable the emergency sample tube to enter or leave the emergency position f.

In the chemiluminescence immunoassay analyzer provided by this embodiment, when in use, the emergency drive 417 drives the emergency sample tube holder 416 to a position far away from the emergency position f, the operator places the emergency sample tube in the emergency sample tube slot, the emergency drive 417 drives the emergency sample tube holder 416 to a position where the emergency sample tube is located at the emergency position f, and the transfer mechanism 430 transfers the emergency sample in the emergency sample tube located at the emergency position f to the blending position a, so that the emergency sample can be detected in time, and the function of the chemiluminescence immunoassay analyzer is completed.

In another embodiment of the present application, referring to fig. 2, the transferring mechanism 430 includes a sample needle 431, a sample arm 432, a sample application driver 433, a reagent needle 434, a reagent arm 435, and a reagent application driver 436, wherein the sample needle 431 is disposed at one end of the sample arm 432, the sample application driver 433 is configured to drive the sample arm 432 to move (may be rotated and lifted) so as to move the sample needle 431 to the sample sucking position b or the mixing position a, the reagent needle 434 is disposed at one end of the reagent arm 435, and the reagent application driver 436 is configured to drive the reagent arm 435 to move (may be rotated and lifted) so as to move the reagent needle 434 to the reagent sucking position d or the mixing position a (see fig. 1).

The chemiluminescence immunoassay analyzer provided by the embodiment can collect a sample in the sample tube positioned at the sample suction position b through the sample needle 431, and simultaneously collect a reagent in the reagent tube positioned at the reagent suction position d through the reagent needle 434, so that the detection efficiency of the chemiluminescence immunoassay analyzer is improved.

Optionally, when the sample injection mechanism 410 is provided with the emergency position f, the movement track of the sample needle 431 intersects with the emergency position f, and can be used for transferring the emergency sample on the emergency position f to the blending position a.

In another embodiment of the present application, referring to fig. 2, the transfer mechanism 430 further includes a first cleaner 437 for cleaning the sample needle 431 and a second cleaner 438 for cleaning the reagent needle 434.

In the chemiluminescence immunoassay analyzer provided by this embodiment, the reagent needle 434 after transferring the sample can be cleaned by the first cleaner 437, and the reagent needle 434 after transferring the reagent can be cleaned by the second cleaner 438, so that the cleaning operations of the reagent needle 434 and the sample needle 431 are not affected, cross-infection is completely avoided, and the detection efficiency is improved.

Referring to fig. 4, since the sample tube is usually attached with information storage carriers such as bar codes for recording information of the sample tube, and the information storage carriers on the sample tube often cannot face the same direction after the sample tube is placed on the sample tube holder 411, the sample tube needs to be rotated by the rotating mechanism 440, so that the first information collecting mechanism 450 can collect information of all sample tubes on the sample tube holder 411 in the same direction.

In another embodiment of the present application, referring to fig. 4, 7 and 8, the rotating mechanism 440 includes a first shaft 441, a second shaft 442, a rotating wheel 443, two pre-pressing wheels 444, a pre-pressing arm 445 and a position adjusting assembly 446, wherein the first shaft 441 and the second shaft 442 are disposed at two sides of the information collecting location c; the rotation wheel 443 is rotatably disposed on the first shaft 441 and is configured to abut against the outer surface of the sample tube located at the information collecting position c to rotate the sample tube; the pre-pressing arm 445 is rotatably sleeved on the second shaft 442, the two pre-pressing wheels 444 are arranged on the pre-pressing arm 445, and the position adjusting assembly 446 is used for applying an elastic force to the pre-pressing arm 445 so that the pre-pressing arm 445 drives the two pre-pressing wheels 444 to elastically press the outer surface of the sample tube located at the information acquisition position c.

It should be noted that the pre-pressing wheel 444 may be fixedly disposed on the pre-pressing arm 445 or rotatably disposed on the pre-pressing arm 445. Compared with the pre-pressing arm 445 which is fixedly arranged on the pre-pressing arm 444, when the pre-pressing wheel 444 is rotatably arranged on the pre-pressing arm 445, the sliding friction between the pre-pressing wheel 444 and the sample tube can be changed into rolling friction, and the sample tube can more smoothly enter and exit the information acquisition position c.

It should be noted that the first shaft 441 of the rotation wheel 443 may be fixedly disposed on the rack 100, or may be disposed on the rack 100 close to or far from the information collecting location c, and when the first shaft 441 of the rotation wheel 443 is movably disposed on the rack 100, the rotation wheel 443 can move in a direction away from the information collecting location c before the sample tube enters the information collecting location c, so as to make more space for the sample tube to enter the information collecting location c, and move in a direction close to the information collecting location c until the sample tube abuts against the outer surface of the sample tube after the sample tube enters the information collecting location c, so as to normally drive the sample tube to rotate.

Before the sample tube does not enter the information collecting position c, the pre-pressing arm 445 and the pre-pressing wheel 444 are in an initial position under the action of the position adjusting assembly 446 (please refer to the position of the pre-pressing arm 445 shown by the solid line in fig. 8), in the process that the sample tube enters the information collecting position c along the sample injection direction, the sample tube pushes the pre-pressing wheel 444, the pre-pressing wheel 444 drives the pre-pressing arm 445 to rotate around the second shaft 442, the pre-pressing arm 445 and the pre-pressing wheel 444 make more room for the sample tube, until the sample tube completely enters the information collecting position c, the pre-pressing arm 445 and the pre-pressing wheel 444 are kept at a position where the pre-pressing wheel 444 can abut against the outer surface of the sample tube under the action of the position adjusting assembly 446 (please refer to the position where the pre-pressing arm 445 shown by the dotted line in fig. 8), then, the rotating wheel 443 abuts against the outer surface of the sample tube and drives the sample tube to rotate, after the sample tube has completed the rotation and leaves the information collecting position c, the pre-pressing arm 445 and the pre-pressing wheel 444 are returned to the initial position again by the position adjusting assembly 446, and the rotation operation for the next sample tube can be continued. The application provides a chemiluminescence immunoassay analyzer, through setting up two pre-compaction wheels 444 on rotatable pre-compaction arm 445, and adjust the position of pre-compaction arm 445 through position control subassembly 446, when the sample tube is located information acquisition position c, pre-compaction wheel 444 can butt in the sample tube surface of tubes, accomplish rotatory operation with the cooperation of swiveling wheel 443, when sample tube business turn over information acquisition position c, pre-compaction wheel 444 and pre-compaction arm 445 can change the position on frame 100 under the promotion of sample tube, give way the removal space for the sample tube, can make sample tube "flexibility" business turn over information acquisition position c, be difficult to appear the card material.

In addition, the chemiluminescent immunoassay analyzer provided by the embodiment can be applied to sample tubes with different diameters because the positions of the pre-pressing wheel 444 and the pre-pressing arm 445 on the rack 100 can be changed under the action of the sample tube and the position adjusting assembly 446, and the application range is wider.

In another embodiment of the present application, referring to fig. 7 and 8, the position adjustment assembly 446 includes a mounting seat 4461, a guide rod 4462 and an elastic member 4463, the mounting seat 4461 is provided with a second shaft 442, and the mounting seat 4461 is further provided with a first limiting surface 4464; the first end of the pre-pressing arm 445 is connected with two pre-pressing wheels 444, and the second end of the pre-pressing arm 445 is provided with a sliding groove 4451; a first end of the guide rod 4462 is in sliding fit with the sliding groove 4451, and a second end of the guide rod 4462 is fixed on the mounting seat 4461; the elastic member 4463 is sleeved on the guide rod 4462 and abuts between the mounting seat 4461 and the pre-pressing arm 445, and after the sample tube leaves the information collecting position c, the pre-pressing arm 445 abuts against the first limiting surface 4464 under the action of the elastic member 4463.

In the chemiluminescence immunoassay analyzer provided in this embodiment, when the sample tube is not in contact with the pre-pressing wheel 444, the pre-pressing arm 445 abuts against the first limiting surface 4464 under the action of the elastic member 4463, when the sample tube enters the information acquisition site c along the sample introduction direction, the sample tube pushes the pre-pressing wheel 444, the pre-pressing wheel 444 pushes the pre-pressing arm 445 to rotate around the shaft body, the pre-pressing arm 445 applies pressure or tension to the elastic member 4463 (when the second end of the guide rod 4462 is disposed on the side of the pre-pressing arm 445 close to the information acquisition site c, the pre-pressing arm 445 applies pressure to the elastic member 4463, when the second end of the guide rod 4462 is disposed on the side of the pre-pressing arm 445 far from the information acquisition site c, the pre-pressing arm 445 applies tension to the elastic member 4463) until the sample tube completely enters the information acquisition site c, at this time, under the action of the elastic force of the elastic member 4463, the pre-pressing wheel on the pre-pressing arm 445 abuts against the outer surface of the sample tube, and then the sample tube is driven to rotate by the rotation wheel 443 on the information acquisition site c, the first information collecting mechanism 450 collects information, and then the sample tube leaves the information collecting position c along the sample introduction direction, and the pre-pressing arm 445 is pressed against the first limiting surface 4464 again under the elastic force of the elastic member 4463. The chemiluminescence immunoassay analyzer provided by the embodiment has the advantages that the rotating mechanism 440 is simple in structure and small in size, and the cost and the design space of the rotating mechanism 440 are greatly saved.

Optionally, the position adjusting assembly 446 includes a torsion spring (not shown), the torsion spring is sleeved on the second shaft 442, one end of the torsion spring abuts against the rack 100, the other end of the torsion spring abuts against the pre-pressing arm 445, when the sample tube is not located at the information collecting position c, the pre-pressing arm 445 and the pre-pressing wheel 444 are located at initial positions under the action of the torsion spring, when the sample tube enters the information collecting position c along the sample injection direction, the sample tube pushes the pre-pressing wheel 444 located at the initial position, the pre-pressing wheel 444 pushes the pre-pressing arm 445 to rotate around the second shaft 442 and press the torsion spring until the sample tube completely enters the information collecting position c, at this time, under the action of the elastic force of the torsion spring, the pre-pressing wheel 444 on the pre-pressing arm 445 abuts against the outer surface of the sample tube, then the sample tube passively rotates under the driving of the rotation wheel 443, and collects information by the first information collecting mechanism 450, then the sample tube leaves the information collecting position c along the sample injection direction, the pre-pressing arm 445 and the pre-pressing wheel 444 are reset to the initial position by the elastic force of the torsion spring.

In another embodiment of the present application, referring to fig. 7 and 8, the mounting seat 4461 includes a substrate 4465 and a pressure plate 4466, the pressure plate 4466 is disposed on the substrate 4465 and can move relative to the substrate 4465, the pressure plate 4466 or the substrate 4465 has a first position-limiting surface 4464, the pressure plate 4466 has a second shaft 442, and the second end of the guide rod 4462 is fixedly connected to the pressure plate 4466.

The chemiluminescence immunoassay analyzer provided by the embodiment can change the position of the pressing plate 4466 on the substrate 4465, synchronously change the positions of the second shaft 442, the prepressing arm 445 and the elastic part 4463, and further adjust the position of the prepressing wheel 444 for pressing the sample tube, so that the position of the prepressing wheel 444 is matched with the position of the sample tube, and the adaptability is better; after the position of the pressing plate 4466 on the substrate 4465 is adjusted, the pressure provided by the pre-pressing wheel 444 to the sample tube is kept unchanged, and the pressure provided by the pre-pressing wheel 444 to the sample tube does not need to be adjusted again after the position of the pressing plate 4466 is adjusted, so that the rotating mechanism 440 has the advantage of easy adjustment; in addition, the rotating mechanism 440 provided by the embodiment reduces the number of corresponding motors or cylinder driving mechanisms, has a simple structure, is low in cost and small in size, and is beneficial to compact product design.

Optionally, the moving direction of the pressure plate 4466 is parallel to the sample introduction direction of the sample tube. Thus, by adjusting the position of the pressing plate 4466 on the base plate 4465 in the direction parallel to the sample introduction direction of the sample tube, the position of the pre-pressing wheel 444 that presses the sample tube can be changed, so that the rotating mechanism 440 matches the position of the sample tube, and the outer surface of the sample tube is pressed at a proper position.

In another embodiment of the present application, referring to fig. 8, the mounting seat 4461 further has a second limiting surface 4467, and the second limiting surface 4467 is used for limiting the distance that the first end of the pre-pressing arm 445 can move in the direction away from the information collecting site c.

It should be noted that the second position-limiting surface 4467 may be a single surface, or may be two or more surfaces parallel to each other, and may be disposed as required, which is not limited herein.

In the chemiluminescence immunoassay analyzer provided by this embodiment, the second limiting surface 4467 cooperates with the first limiting surface 4464 to limit the rotation of the pre-pressing arm 445 within a certain range, so as to minimize the volume of the rotation mechanism 440, and the second limiting surface 4467 can prevent the over-compression or multi-degree stretching of the elastic member 4463 caused by the excessive rotation of the end of the pre-pressing arm 445 provided with the pre-pressing wheel 444 in the direction away from the information acquisition position c.

In another embodiment of the present application, referring to fig. 7 and 8, the position adjustment assembly 446 further includes an adjustment wheel 4468, the adjustment wheel 4468 is sleeved on the guide rod 4462 and can move along the axial direction of the guide rod 4462, and the elastic member 4463 abuts between the adjustment wheel 4468 and the pre-pressing arm 445.

It should be noted that the adjusting wheel 4468 may be disposed on the guide rod 4462 in various ways, for example, as described in the above embodiments, the second end of the guide rod 4462 is disposed on one side of the pre-pressing arm 445 close to the information collecting position c, and the elastic element 4463 is in a compressed state, for example, the adjusting wheel 4468 is provided with an internal thread, the guide rod 4462 is provided with an external thread adapted to the internal thread, the adjusting wheel 4468 is sleeved on the part of the guide rod 4462 provided with the external thread, and the adjusting wheel 4468 is rotated to move the adjusting wheel 4468 on the guide rod 4462 in a direction close to the pre-pressing arm 445, so that the elastic element 4463 is further contracted, and further the pressure of the pre-pressing wheel 444 on the pre-pressing arm 445 on the outer surface of the sample tube is increased; rotating the adjustment wheel 4468 causes the adjustment wheel 4468 to move on the guide 4462 away from the arm 445, which causes the spring 4463 to extend, thereby reducing the pressure of the pre-pressure wheel 444 on the arm 445 on the outer surface of the sample tube. For another example, the adjusting wheel 4468 is slidably sleeved on the guide rod 4462, a row of positioning holes (not shown) is axially formed in the guide rod 4462, and after the adjusting wheel 4468 is moved to a desired position, a positioning member (not shown) can be inserted into the corresponding positioning hole, and the adjusting wheel 4468 is fixed at the desired position by the positioning member.

The chemiluminescence immunoassay analyzer provided by the embodiment can adjust the pressing force of the pre-pressing wheel 444 on the sample tube by changing the position of the adjusting wheel 4468 on the guide rod 4462, so that the difficulty of adjusting the pre-pressing force is greatly reduced, and the device has a simple structure and is convenient to operate.

In another embodiment of the present application, referring to fig. 7 and 8, when the sample tube leaves the information collecting position c (the pre-pressing arm 445 is located at the position of the pre-pressing arm 445 shown by the solid line in fig. 8), the vertical distance between the pre-pressing wheel 444 located at the sample feeding side of the information collecting position c and the straight line of the sample feeding direction is greater than the vertical distance between the pre-pressing wheel 444 located at the discharge side of the information collecting position c and the straight line of the sample feeding direction.

The chemiluminescence immunoassay analyzer provided by the embodiment can enable the sample tube to enter the information acquisition position c more smoothly when the sample tube gradually moves to the direction close to the information acquisition position c along the sample introduction direction by enabling the connecting line of the centers of the two pre-pressing wheels 444 and the sample introduction direction to keep inclined when the sample tube is not positioned at the information acquisition position c.

Optionally, in a state where the sample tube is completely away from the information collecting location c, an included angle between a connecting line of centers of the two pre-pressing wheels 444 and the sample introduction direction of the sample tube is 2 ° to 15 °.

In another embodiment of the present application, referring to fig. 7 and 8, a groove 4452 is formed on the pre-pressing arm 445 between the pre-pressing wheels 444.

It should be noted that the size of the groove 4452 may be set according to the external size of the sample tube, and is not limited herein.

The chemiluminescence immunoassay analyzer provided by the embodiment can enable the sample tube to gradually enter the information acquisition position c more smoothly when moving towards the direction close to the information acquisition position c along the sample introduction direction by arranging the groove 4452.

In another embodiment of the present application, please refer to fig. 1 and 2, the incubation cleaning system 500 includes a pot 510, a cleaning disc 520, an incubation disc 530, an incubation driver 540, a cleaning driver 550 and a cleaning module 560, the pot 510 is disposed on the rack 100, the incubation disc 530 and the cleaning disc 520 are coaxially disposed in the pot 510, the incubation disc 530 is disposed above the cleaning disc 520, and an inner diameter of the incubation disc 530 is smaller than an inner diameter of the cleaning disc 520, an incubation groove for accommodating a reaction cup is disposed at an upper portion of the incubation disc 530, a cleaning groove for accommodating a reaction cup is disposed at a portion of the cleaning disc 520 beyond the incubation disc 530, the incubation driver 540 is configured to drive the incubation disc 530 to rotate, and the cleaning driver 550 is configured to drive the reaction cup on the cleaning disc 520 to the cleaning module 560 to perform cleaning, substrate filling operation and blending operation.

Specifically, the incubation cleaning system 500 further comprises a rotating shaft 570 and a rotating sleeve 580, the rotating sleeve 580 is rotatably sleeved on the rotating shaft 570 through a bearing, the incubation disc 530 is fixedly sleeved on the periphery of the rotating shaft 570, and the incubation driver 540 is arranged below the pot body 510 and is used for sequentially driving the rotating shaft 570 and the incubation disc 530; the cleaning disc 520 is fixedly sleeved on the periphery of the rotary sleeve 580, and the cleaning driver 550 is arranged below the pot body 510 and is used for driving the rotary sleeve 580 and the cleaning disc 520 in sequence.

The chemiluminescence immunoassay analyzer provided by the embodiment has the advantages that through reasonable structural design, incubation operation and cleaning operation are carried out in the same pot body 510, mutual influence is avoided, and the compact design of products is facilitated.

Optionally, the pan body 510 of the incubation and washing system 500 includes a pan bottom 511 and a cover body 512, and the cover body 512 is provided with an incubation position g for placing or taking out the reaction cup into or from the incubation groove and a washing position h for placing the reaction cup into the washing groove.

In another embodiment of the present application, please refer to fig. 5 and 6, the cleaning module 560 includes a first lifting plate 561, a plurality of liquid sucking needles 562 disposed on the first lifting plate 561 along the circumference of the first lifting plate 561, a second lifting plate 563, and liquid injection needles 564 disposed on the second lifting plate 563 along the circumference of the second lifting plate 563 and having the same number as the liquid sucking needles 562, the liquid sucking needles 562 and the liquid injection needles 564 are alternately disposed, a liquid sucking position i is disposed below the liquid sucking needle 562, a liquid injection position j is disposed below the liquid injection needle 564, and when the cleaning disk 520 rotates, the reaction cup is driven to each liquid sucking position i to suck liquid and driven to each liquid injection position j to inject liquid.

It should be noted that, wash module 560 still includes the magnetic separation piece (not shown in the figure) that sets up in the lateral wall of pot body 510, and the reaction cup is annotated the liquid position j by annotating liquid needle 564 and pours into the washing liquid into, and the reaction cup rotates to imbibition position i, and under the magnetic field of magnetic separation piece, the magnetic bead that is located the reaction cup of imbibition position i adsorbs on the wall of cup of reaction cup, and when imbibition operation, reducible magnetic bead loses, guarantees the accuracy of follow-up detection.

In the chemiluminescence immunoassay analyzer provided by the embodiment, the liquid suction needle 562 is driven by the first lifting plate 561, and the liquid injection needle 564 is driven by the second lifting plate 563, so that the liquid injection operation and the liquid suction operation are not affected by each other.

Optionally, the first lifting plate 561 and the second lifting plate 563 are driven by a linear motor to move up and down.

Optionally, be provided with four imbibition needles 562 on the first lifter plate 561, be provided with four notes liquid needles 564 on the second lifter plate 563, can carry out quadruple washing to the reaction liquid in the reaction cup, it is effectual to wash abundant, is favorable to promoting the detection precision.

In another embodiment of the present application, referring to fig. 5, the incubation cleaning system 500 further comprises two substrate liquid filling pipes 590, wherein the two substrate liquid filling pipes 590 are used for filling the substrate liquid required by direct chemiluminescence and the substrate liquid required by enzymatic chemiluminescence into the reaction cup after the cleaning operation.

It should be noted that the substrate solution required for direct chemiluminescence may be hydrogen peroxide and sodium hydroxide solution, and the substrate solution required for enzymatic chemiluminescence may be luminol, which may be selected according to the need, and is not limited herein.

The chemiluminescence immunoassay analyzer provided by the embodiment can be suitable for direct chemiluminescence analysis and enzymatic chemiluminescence analysis, and is good in adaptability.

In another embodiment of the present application, referring to fig. 1, 9 and 10, the light measuring system 600 includes a dark box 610, a light shielding driver 620, a light shielding assembly 630 and a photomultiplier tube 640, the dark box 610 has an accommodating cavity 611, a first light hole 612 and a second light hole 613 are oppositely disposed on a cavity wall of the accommodating cavity 611, the light shielding driver 620 is disposed on the dark box 610, and one end of an output shaft of the light shielding driver 620 is disposed in the accommodating cavity 611; the photomultiplier tube 640 is installed at the first light hole 612 and receives a light signal through the first light hole 612, the light shielding assembly 630 is disposed inside the accommodating cavity 611, the light shielding assembly 630 includes a light shielding arm 631 and a swing arm 632, a positioning pin 614 is disposed on a cavity wall of the accommodating cavity 611, the light shielding arm 631 is rotatably sleeved on the positioning pin 614, one end of the swing arm 632 is connected to an output shaft of the driver, and the other end of the swing arm 632 is used for driving the light shielding arm 631 to rotate, so that the light shielding arm 631 shields the second light hole 613 or moves away from the second light hole 613.

Alternatively, the photometric system 600 is integrally installed at a side portion of the pot body 510, and the sidewall of the pot body 510 is provided with an installation hole 513 (see fig. 6), and the second light hole 613 of the dark box 610 can receive light emitted from the substances in the reaction cup after the incubation operation, the cleaning operation, the substrate filling operation, and the mixing operation are completed in the pot body 510 through the installation hole 513.

When the chemical luminescence immunoassay analyzer needs to adopt the photomultiplier tube 640 for testing, the light shielding driver 620 drives the swing arm 632, and the swing arm 632 drives the light shielding arm 631 to move away from the second light hole 613, so that an optical signal to be tested enters a detection port of the photomultiplier tube 640 through the second light hole 613 and the first light hole 612 in sequence, the photomultiplier tube 640 can complete testing in a state without ambient light, and the testing precision is high; when the photomultiplier tube 640 needs to be installed or maintained, the light shielding driver 620 drives the swing arm 632, the swing arm 632 drives the light shielding arm 631 to move to shield the second light transmission hole 613, so that no light enters the accommodating cavity 611, the photomultiplier tube 640, the dark box 610, the light shielding driver 620 and the light shielding assembly 630 are installed and maintained together from the pot body 510, and the photocathode of the detection port of the photomultiplier tube 640 is always in a dark environment and cannot be damaged.

In another embodiment of the present application, referring to fig. 1 and 2, the chemiluminescent immunoassay analyzer further comprises a cup disposal system 800, wherein the cup disposal system 800 comprises a waste fluid recycling mechanism 810 for recycling the contents of the used cuvettes and a waste cup recycling mechanism 820 for recycling the used cuvettes.

A waste cup taking position k (see fig. 5) for taking the reaction cup with the photometry completed out of the pot body 510 is arranged on the cover body 512 of the pot body 510 of the incubation cleaning system 500, the waste cup recycling mechanism 820 takes the reaction cup out of the cup taking opening of the waste cup, the waste liquid recycling mechanism 810 recycles the waste liquid in the reaction cup, and the waste cup recycling mechanism 820 discards the reaction cup to the reaction cup collecting box through the cup throwing position m (see fig. 1).

In another embodiment of the present application, referring to fig. 1, the carrying mechanism 220 can move the reaction cup in the horizontal direction and the vertical direction, the motion track of the carrying mechanism 220 intersects with at least the blending position a, the cup feeding position e, the incubation position g, the cleaning position h and the waste cup taking position k, and the reaction cup is carried between the above positions by the cup clamping and pushing functions.

One of the test procedures of the chemiluminescence immunoassay analyzer provided in this embodiment is as follows:

referring to fig. 11, the analyzer is started, the analyzer is initialized, the whole analysis process starts, the transferring unit 212 of the cup feeding mechanism 210 feeds the cuvettes in the loading storage unit 211 to the rotating disc 213, the rotating disc 213 rotates to bring the cuvettes to the cup feeding position e, the carrying mechanism 220 carries the newly fed cuvettes from the cup feeding position e to the mixing position a of the mixing system 300, the sample tube holder 411 of the sample pre-detection placement area 413 is driven to the sample feeding track 414 by the sample feeding driver 412 of the sample feeding mechanism 410, the sample is moved to the sample sucking position b on the sample feeding track 414, the sample on the sample sucking position b is transferred to the mixing position a by the sample feeding driver 433 of the transferring mechanism 430, the matched reagent tube is driven to the reagent sucking position d by the reagent disk driver 423 of the reagent disk mechanism 420, the reagent feeding driver 436 of the transferring mechanism 430 transfers the reagents in the reagent tubes on the reagent sucking position d to the mixing position a, the blending system 300 blends the liquid in the reaction cup at the blending position a, after blending, the carrying mechanism 220 carries the reaction cup at the blending position a to the incubation cleaning system 500, and the reaction cup is put into the incubation groove from the incubation position g of the incubation cleaning system 500 for incubation operation, after the incubation operation is finished, the carrying mechanism 220 takes out the reaction cup from the pot body 510 through the incubation position g, and then puts into the cleaning groove through the cleaning position h, the reaction liquid in the reaction cup is cleaned by the cleaning module 560 in the cleaning tank, after the cleaning operation is finished, the required substrate liquid is filled into the reaction cup by the substrate liquid filling pipe 590, and the materials in the used reaction cup and the materials in the reaction cup are recovered by the cup throwing system 800 after the optical detection is finished by directly carrying out the optical detection on the materials in the reaction cup after the mixing by the incubation cleaning system 500 by a mixing structure. The whole detection process is automatically finished, and the detection accuracy and reliability can be prevented from being influenced by human factors.

The above description is only exemplary of the present application and should not be taken as limiting the present application, as any modification, equivalent replacement, or improvement made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims

1. A chemiluminescence immunoassay analyzer is characterized by comprising a rack, and a reaction cup feeding and conveying system, a blending system, an acquisition system, an incubation and cleaning system, a photometric system and a control system which are arranged on the rack;

2. The chemiluminescent immunoassay analyzer of claim 1, wherein the transferring mechanism comprises a sample needle, a sample arm, a sample adding driver, a reagent needle, a reagent arm and a reagent adding driver, wherein the sample needle is disposed at one end of the sample arm, the sample adding driver is used for driving the sample arm to move so as to move the sample needle to the sample sucking position or the mixing position, the reagent needle is disposed at one end of the reagent arm, and the reagent adding driver is used for driving the reagent arm to move so as to move the reagent needle to the reagent sucking position or the mixing position.

3. The chemiluminescent immunoassay analyzer of claim 2, wherein the transfer mechanism further comprises a first washer for washing the sample needle and a second washer for washing the reagent needle.

4. The chemiluminescent immunoassay analyzer of claim 1, wherein the rotating mechanism comprises a first shaft, a second shaft, a rotating wheel, a pre-pressing arm, two pre-pressing wheels and a position adjusting assembly, wherein the first shaft and the second shaft are arranged at two sides of the information collecting position; the rotating wheel is rotatably arranged on the first shaft and is used for abutting against the outer surface of the sample tube positioned at the information acquisition position so as to rotate the sample tube; the pre-pressing arm is rotatably sleeved on the second shaft, the two pre-pressing wheels are arranged on the pre-pressing arm, and the position adjusting assembly is used for applying elastic force to the pre-pressing arm so that the pre-pressing arm drives the two pre-pressing wheels to elastically press the outer surface of the sample tube located at the information acquisition position.

5. The chemiluminescent immunoassay analyzer of claim 4, wherein the position adjusting assembly comprises a mounting seat, a guide rod and an elastic member, the mounting seat is provided with the second shaft, and the mounting seat is further provided with a first limiting surface; the first end of the pre-pressing arm is connected with two pre-pressing wheels, and the second end of the pre-pressing arm is provided with a sliding groove; the first end of the guide rod is in sliding fit with the sliding groove, and the second end of the guide rod is fixed on the mounting seat; the elastic piece is sleeved on the guide rod and abutted between the mounting seat and the pre-pressing arm, and after the sample tube leaves the information acquisition position, the pre-pressing arm is abutted to the first limiting surface under the action of the elastic piece.

6. The chemiluminescence immunoassay analyzer of claim 1, wherein the incubation cleaning system comprises a pot body, a cleaning disc, an incubation driver, a cleaning driver and a cleaning module, the pot body is arranged on the frame, the incubation disc and the cleaning disc are coaxially arranged in the pot body, the incubation disc is positioned above the cleaning disc, the inner diameter of the incubation disc is smaller than that of the cleaning disc, an incubation groove for accommodating the reaction cup is arranged at the upper part of the incubation disc, a cleaning groove for accommodating the reaction cup is arranged at the part of the cleaning disc, which exceeds the incubation disc, the incubation driver is used for driving the incubation disc to rotate, the cleaning driver is used for driving the cleaning disc to rotate so as to drive the reaction cup on the cleaning disc to perform cleaning operation to the cleaning module, Substrate filling operation and mixing operation.

7. The chemiluminescent immunoassay analyzer of claim 6, wherein the cleaning module comprises a first lifting plate, a plurality of liquid sucking needles disposed on the first lifting plate along the circumferential direction of the first lifting plate, a second lifting plate, and liquid injection needles disposed on the second lifting plate along the circumferential direction of the second lifting plate and having the same number as the liquid sucking needles, the liquid sucking needles and the liquid injection needles are alternately disposed, a liquid sucking level is disposed below the liquid sucking needles, a liquid injection level is disposed below the liquid injection needles, and the cleaning disc drives the reaction cup to each liquid sucking level to suck liquid and drives the reaction cup to each liquid injection level to inject liquid when rotating.

8. The chemiluminescent immunoassay analyzer of claim 1, wherein the incubation and cleaning system further comprises two substrate liquid filling tubes, and the two substrate liquid filling tubes are respectively used for filling substrate liquid required by direct chemiluminescence and substrate liquid required by enzymatic reaction chemiluminescence into the reaction cup after the cleaning operation.

9. The chemiluminescence immunoassay analyzer of claim 1, wherein the photometric mechanism comprises a dark box, a shading driver, a shading assembly and a photomultiplier, the dark box is provided with a containing cavity, a first light hole and a second light hole which are oppositely arranged are arranged on the cavity wall of the containing cavity, the shading driver is arranged on the dark box, and one end of an output shaft of the shading driver is arranged in the containing cavity; the photomultiplier install in first light trap department and pass through light signal is received to first light trap, the shading subassembly set up in the inside in holding chamber, the shading subassembly includes shading arm and swing arm, be equipped with the locating pin on the chamber wall in holding chamber, the shading arm rotationally overlaps and locates on the locating pin, the one end of swing arm connect in the output shaft of shading driver, just the other end of swing arm is used for driving the shading arm is rotatory, so that the shading arm shelters from the second light trap or follows second light trap department puts aside.

10. The chemiluminescent immunoassay analyzer of any one of claims 1 to 9, further comprising at least one of:

the sample feeding mechanism comprises an emergency treatment sample tube bracket and an emergency treatment driver, the sample feeding mechanism is also provided with an emergency treatment position, the emergency treatment position is positioned on the motion track of the transfer mechanism, the emergency treatment sample tube bracket is provided with an emergency treatment sample tube groove for accommodating an emergency treatment sample tube, and the emergency treatment driver is used for driving the emergency treatment sample tube bracket to move on the rack so as to enable the emergency treatment sample tube on the emergency treatment sample tube to enter or leave the emergency treatment position;

the sample feeding mechanism further comprises a sample tube bracket and a sample feeding driver, the information collecting position is located on the sample feeding side of the sample sucking position, the sample tube bracket is provided with a plurality of sample tube grooves for accommodating the sample tubes, and the sample feeding driver is used for driving the sample tube bracket to move on the rack so as to enable the sample tubes on the sample tube bracket to sequentially pass through the sample sucking position and enable the sample tubes to sequentially pass through the information collecting position;

the cup feeding mechanism comprises a loading storage part, a conveying part and a rotating disc, wherein the loading storage part is arranged on the rack and used for loading and storing the reaction cups, the conveying part is arranged on one side of the loading storage part and is butted with the loading storage part, and the rotating disc is butted with the conveying part; and

the chemiluminescence immunoassay analyzer also comprises a cup throwing system, wherein the cup throwing system comprises a waste liquid recovery mechanism for recovering substances in the used reaction cups and a waste cup recovery mechanism for recovering the used reaction cups.