CN114191515A - Oral gel for dispelling dampness, invigorating stomach and improving immunity and preparation method thereof - Google Patents
Oral gel for dispelling dampness, invigorating stomach and improving immunity and preparation method thereof Download PDFInfo
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- CN114191515A CN114191515A CN202111482073.5A CN202111482073A CN114191515A CN 114191515 A CN114191515 A CN 114191515A CN 202111482073 A CN202111482073 A CN 202111482073A CN 114191515 A CN114191515 A CN 114191515A
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- oral gel
- improving immunity
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- invigorating stomach
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Abstract
The invention relates to an oral gel for clearing damp, invigorating stomach and improving immunity and a preparation method thereof, belonging to the field of food processing and comprising the following raw materials in parts by weight: 1000 portions of tuckahoe, 1500 portions of coix seed, 1000 portions of scorched hawthorn, 500 portions of kudzuvine root, and 10 to 30 portions of phaseolus calcaratus; the invention also discloses a preparation method of the oral gel; the oral gel prepared by the invention has the advantages of high elasticity, low sugar content and easy digestion, has the effects of removing moisture, strengthening spleen, stimulating appetite, improving immunity, protecting liver and preventing cardiovascular diseases, and is particularly suitable for middle-aged and elderly people, white-collar people with fast life rhythm, frequent drinkers with much reward, hypertension, hyperlipidemia and other people.
Description
Technical Field
The invention belongs to the field of food processing, and particularly relates to an oral gel for clearing damp, invigorating stomach and improving immunity and a preparation method thereof.
Background
Moisture is a theoretical concept of traditional Chinese medicine. According to traditional Chinese medicine, the climate dampness, diet and daily life irregularity in the nature are the source of the moisture, and the excessive dampness tends to damage yang qi and damage the body. Irregular daily life of food, food pollution and less exercise amount can cause yin exuberance and yang deficiency of a body, so that dampness in the body is stagnated, the spleen and the stomach can be injured if the dampness in the body is accumulated, the spleen and the stomach have the function of transporting and transforming the dampness, and the spleen and the stomach are injured by the dampness, so that the dampness can not be completely transported and transformed and accumulated in the body.
The long-term overweight of the damp can not only damage the spleen and the stomach, but also reduce the immunity of the human body, so that the human body is in a sub-health state for a long time. Immune competence is the body's own defense mechanism, and is the body's ability to recognize and destroy any foreign body (virus, bacteria, etc.) invaded from the outside, to treat aged, damaged, dead, denatured self cells, and to recognize and treat mutant cells and virus-infected cells in the body.
Therefore, eliminating dampness and strengthening the stomach are the key points for improving the immunity and avoiding the generation of sub-health. Clinically, the syndrome of dampness generation in the spleen and stomach and dampness retention in the spleen and stomach is usually treated with spleen invigorating and dampness eliminating, so called "treating dampness does not treat spleen and stomach, but not treating it. Traditional Chinese medicine considers that moisture can be regulated by taking traditional Chinese medicines, but traditional Chinese medicines boiled in the traditional Chinese medicine cannot meet the life rhythm of modern people, so that functional health food is more and more popular. Gel foods are popular among more and more consumers due to the characteristics of low calorie, easy digestion, elastic mouthfeel, easy chewing and the like. The existing gel food mainly adopts pure candies, and cannot meet the requirements of people on body regulation, dampness elimination and stomach strengthening, so that the health edible gel prepared by adding medicinal and edible plants or medicinal materials is required to meet the requirements of people on body regulation, dampness elimination, stomach strengthening and immunity improvement.
Disclosure of Invention
In order to overcome the problems in the background art, the invention aims to provide the oral gel for clearing damp, invigorating stomach and improving immunity, wherein a plurality of medicinal materials are decocted into the gel firstly, the effective ingredients of the medicinal materials are dispersed in the gel, the gel fully wraps the effective ingredients of the medicinal materials, the retention time of the medicinal materials in a user body is prolonged, the complete absorption of the medicinal materials is ensured, and the oral gel is convenient and quick to take.
Another object of the present invention is to provide a method for preparing said oral gel.
In order to realize the purpose, the invention is realized by the following technical scheme:
the oral gel for clearing damp, invigorating stomach and improving immunity comprises the following raw materials in parts by weight: 1000 portions of tuckahoe, 1500 portions of coix seed, 1000 portions of scorched hawthorn, 500 portions of kudzuvine root, and 10 to 30 portions of phaseolus calcaratus.
Further, the oral gel for clearing damp, invigorating stomach and improving immunity further comprises the following components in parts by weight: 5-50 parts of rubber powder, 1-400 parts of sweetening agent, 0.1-1.5 parts of preservative, 0.5-10 parts of pH regulator and 0.5-50 parts of flavoring agent.
Furthermore, the gelatine powder is one or more of carrageenan, xanthan gum, gelatin, konjac flour and maltodextrin.
Furthermore, the sweetening agent is one or more of sucrose, xylitol, honey, sucralose, aspartame, fructo-oligosaccharide and trehalose.
Furthermore, the preservative is one or more of sorbic acid and potassium sorbate.
Furthermore, the pH regulator is one or more of malic acid, citric acid, lactic acid, sodium citrate, potassium citrate and potassium chloride.
Furthermore, the flavoring agent is one or more of milk powder, essence and fruit juice.
The preparation method of the oral gel for clearing damp, invigorating stomach and improving immunity comprises the following steps: (1) weighing the raw traditional Chinese medicines according to the parts by weight, decocting the raw traditional Chinese medicines with water for 3 times respectively, each time lasting for 1.5 hours, filtering the extracting solution, combining the filtrates of the raw traditional Chinese medicines, concentrating into an extract with the relative density of 1.25, adding ethanol to ensure that the ethanol content is 65%, standing for 24 hours, filtering, concentrating the filtrate to obtain a fluid extract with the specific gravity of 1.3 for later use;
(2) weighing the rubber powder according to the weight parts, adding water to soak and dissolve, and obtaining a colloidal solution for later use after swelling or complete dissolution;
(3) weighing a sweetening agent, a preservative, a flavoring agent and a pH regulator according to parts by weight, adding water for dissolving, and heating to obtain syrup for later use;
(4) and (3) mixing the fluid extract, the colloidal solution and the syrup prepared in the steps (1), (2) and (3), adding water to the total weight of 1500 parts, uniformly mixing, filtering, sterilizing and subpackaging to obtain the traditional Chinese medicine.
In the traditional Chinese medicine fluid extract, the pharmacological actions of the raw materials are as follows:
pueraria lobata (Willd.) Ohwi is dry root of Pueraria lobata Ohwi of Leguminosae, and is called as Pueraria lobata Ohwi. Mainly contains hydrate, vegetable protein, a plurality of vitamins and mineral substances, and also contains flavonoid substances: daidzein and daidzin can be daidzein-4, 7-diglucoside, puerarin-7-xyloside, puerarin, radix Puerariae and isoflavone glycoside, etc. Kudzuvine root has the functions of expelling pathogenic factors from muscles, allaying fever, promoting eruption, promoting the production of body fluid to quench thirst, invigorating yang and stopping diarrhea. It is commonly used to characterize fever, measles without adequate eruption, fever with thirst, yin deficiency with thirst, heat diarrhea and dysentery, spleen deficiency with diarrhea, etc. Has the effects of improving hepatocyte regeneration ability, recovering normal liver skill, promoting bile secretion, and preventing fat accumulation in liver. Promoting metabolism, enhancing liver detoxification function, and preventing alcohol damage to liver. Radix Puerariae can also be used for preventing and treating cardiovascular and cerebrovascular diseases such as coronary atherosclerotic heart disease, angina pectoris, myocardial infarction, and cerebral arteriosclerosis by improving myocardial ischemia state. By strengthening the autoimmune function of the hepatobiliary cells, the virus invasion is resisted.
Poria is dried sclerotium of Poria cocos (Schw.) wolf of Polyporaceae. Contains beta-pachyman, pachymic acid, 3 beta-hydroxy lanostane trienoic acid, lecithin, lipase, protease, etc. Excrete dampness and promote diuresis, benefit spleen and stomach, calm heart and induce tranquilization. It is indicated for difficulty in micturition, edema, abdominal distention, expectoration, emesis, diarrhea, spermatorrhea, stranguria with turbid urine, palpitation, and amnesia.
Coix seed is a traditional health food used as both medicine and food in China. The Coicis semen has effects of inducing diuresis, relieving swelling, invigorating spleen, eliminating dampness, clearing heat, expelling pus, relieving inflammation and pain, and enhancing immunity. Coix seed polysaccharide is rich in polysaccharide, wherein A, B, C sugar in the polysaccharide has blood sugar lowering effect. Coix seed is a common medicine-food dual-purpose Chinese medicine, has high nutritive value and is called as king of Gramineae. Contains fatty acid, esters, polysaccharide, flavone, triterpene, alkaloid, sterol, lactam, starch, etc., and can exert different effects when Coicis semen is used for treating diseases, so as to achieve the purpose of treatment.
The hawthorn has the functions of reducing blood fat, blood pressure, strengthening heart, resisting arrhythmia and the like, is also a good medicine for strengthening spleen, stimulating appetite, promoting digestion, removing stagnation, promoting blood circulation and reducing phlegm, and has good curative effects on symptoms such as chest, diaphragm, spleen fullness, hernia, blood stasis, amenorrhea and the like. The vitexin is a flavonoid compound in hawthorn, is a drug with strong anticancer effect, and the extract of the vitexin has certain effects on inhibiting the growth, proliferation and infiltration and metastasis of cancer cells in vivo.
Red bean has the effects of inducing diuresis to alleviate edema, detoxifying and expelling pus. Can be used for treating edema, tinea pedis, edema, jaundice, dark urine, rheumatism, pyretic arthralgia, carbuncle, suppurative sore, intestinal carbuncle, and abdominal pain. The red bean is rich in dietary fiber, and has effects of loosening bowel to relieve constipation, lowering blood pressure, reducing blood lipid, regulating blood sugar, removing toxic substance, resisting cancer, preventing calculus, building body and reducing weight; semen Phaseoli contains saponin, has diuretic, anti-hangover and toxic materials removing effects, and is beneficial to heart disease, nephropathy and edema; red bean is rich in folic acid; the red bean contains considerable protein and microelements, which is beneficial to enhancing the immune function of the body and improving the disease resistance.
The invention has the beneficial effects that:
(1) compared with gel candies added with concentrated juice on the market, the oral gel has the effects of improving the immunity of the health-care medicinal materials, protecting the liver and preventing cardiovascular diseases, and is particularly suitable for middle-aged and elderly people with low immunity and cardiovascular diseases needing health care and prevention. Is also suitable for white-collar workers with fast pace of life, frequent drinkers with much reward, crowds with hypertension, hyperlipidemia and the like.
(2) Compared with the common gel candies in the market, the oral gel prepared by the invention has the characteristics of high elasticity and low sugar, and is added with fructo-oligosaccharide to help digestion. The fructo-oligosaccharide will not be decomposed by various digestive enzymes in human digestive tract, and can be selectively utilized by beneficial bacteria such as acidophilic lactobacillus and Bacillus bifidus in intestinal tract, so that they can rapidly and massively propagate. The probiotics as microecological regulator has effects of promoting absorption of nutrient substances, enhancing immunity, preventing and treating constipation and diarrhea, reducing blood lipid, inhibiting intestinal tract pathogenic and putrefactive microorganism growth, and decomposing carcinogen. And the fructo-oligosaccharide is the best nutrient for the probiotics. The elderly are deficient in probiotics, and the appropriate supplementation of fructo-oligosaccharides is more helpful to maintain the balance of intestinal flora.
(3) Compared with the medicines or health products with the effect of eliminating dampness in the market, the oral gel prepared by the invention not only covers the bitter taste of the traditional Chinese medicine, but also has better taste and elasticity, and is convenient to carry and take. Also has low sugar content, and can regulate probiotic flora and promote digestion. It also has effects in invigorating spleen, benefiting stomach, and improving immunity.
(4) In the invention, the kudzuvine root contains a large amount of puerarin which belongs to flavonoid substances, has the functions of reducing the body mass and reducing the blood sugar, and can improve the expression of leptin receptor genes so as to play a role in losing weight; puerarin can promote cholesterol to be converted into cholic acid, and then is discharged out of the body, so that TC level is reduced; puerarin can also reduce oxygen consumption of cardiac muscle by slowing down heart rhythm and reducing total peripheral resistance of heart, and further improve working efficiency of essential muscle; puerarin also has anti-inflammatory effect by influencing the secretion of inflammatory factors.
In the invention, the coix seed and the phaseolus calcaratus contain phytosterol, and the phytosterol has a plurality of benefits to human health. Researches show that the phytosterol has the effects of reducing blood cholesterol, preventing and treating prostatic hyperplasia, inhibiting tumors, inhibiting hyperplasia of mammary glands, regulating immunity and the like. Hyperlipidemia refers to the phenomenon of excessive high level of Total Cholesterol (TC) or Triglyceride (TG) or low level of high density lipoprotein cholesterol (HDL-C) in serum. The phytosterol has similar structure to cholesterol, and can inhibit the absorption of cholesterol in small intestine, thereby effectively reducing TC and low density lipoprotein cholesterol (LDL-C) in blood serum
In the compatibility of the invention, puerarin and phytosterol jointly act, cholesterol is precipitated and replaced, the two compete with each other to hinder the absorption of the cholesterol, and then the expression of 7 alpha-hydroxylase (CYP 7A1) is up-regulated, so that the conversion of the cholesterol to cholic acid is promoted, and the cholesterol is discharged from the body, thereby playing the roles of losing weight, reducing fat and regulating intestines and stomach.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, preferred embodiments of the present invention will be described in detail below to facilitate understanding of the skilled person.
Example 1
(1) Weighing the following raw materials in parts by weight: 1000 parts of poria cocos, 1500 parts of semen coicis, 1400 parts of scorched hawthorn, 400 parts of radix puerariae and 10 parts of phaseolus calcaratus are respectively decocted with water for 3 times, the water amount added for each time is 6 times of the weight of the raw materials, the extracting solution is filtered, the filtrate of the raw materials is combined, concentrated into an extract with the relative density of 1.25, ethanol is added to ensure that the alcohol content is 65%, the mixture is kept stand for 24 hours and then filtered, and 14 parts of fluid extract with the specific gravity of 1.3 is obtained after the filtrate is concentrated for later use;
(2) weighing 5 parts of carrageenan, adding water to soak and dissolve the carrageenan, and obtaining a colloidal solution for later use after swelling or complete dissolution;
(3) weighing 400 parts of sucrose, 0.5 part of potassium sorbate, 0.5 part of essence and 0.5 part of citric acid, adding water for dissolving, and heating to obtain syrup for later use;
(4) and (3) combining the fluid extract, the colloidal solution and the syrup prepared in the steps (1), (2) and (3), adding water to the total weight of 1500 parts, uniformly mixing, filtering, sterilizing, and subpackaging 15 parts per bag to obtain the traditional Chinese medicine composition.
Example 2
(1) Weighing the following raw materials in parts by weight: 1500 parts of poria cocos, 1250 parts of coix seeds, 1250 parts of scorched hawthorn fruits, 500 parts of kudzuvine roots and 20 parts of phaseolus calcaratus are respectively decocted with water for 3 times, the water adding amount is 6 times of the weight of the raw materials each time, the extracting solution is filtered, the filtrate of the raw materials is combined and concentrated into an extract with the relative density of 1.25, ethanol is added to ensure that the alcohol content is 65%, the mixture is kept stand for 24 hours and then filtered, and 10 parts of fluid extract with the specific gravity of 1.3 is obtained after the filtrate is concentrated for later use;
(2) weighing 10 parts of carrageenan and 10 parts of konjac flour, adding water, soaking and dissolving, and obtaining a colloidal solution for later use after swelling or complete dissolution;
(3) weighing 300 parts of xylitol, 50 parts of fruit juice, 10 parts of fructo-oligosaccharide, 1 part of sucralose and 0.1 part of potassium sorbate, adding water for dissolving, and heating to obtain syrup for later use;
(4) and (3) combining the fluid extract, the colloidal solution and the syrup prepared in the steps (1), (2) and (3), adding water to the total weight of 1500 parts, uniformly mixing, filtering, sterilizing, and subpackaging 15 parts per bag to obtain the traditional Chinese medicine composition.
Example 3
(1) Weighing the following raw materials in parts by weight: 1800 parts of poria cocos, 1000 parts of semen coicis, 1000 parts of scorched hawthorn fruit, 280 parts of radix puerariae and 10 parts of phaseolus calcaratus, decocting with water for 3 times respectively, adding water for 6 times of the weight parts of the raw materials each time, and 1.5 hours each time, filtering the extracting solution, combining the filtrates of the raw materials, concentrating into an extract with a relative density of 1.25, adding ethanol to ensure that the ethanol content is 65%, standing for 24 hours, filtering, and concentrating the filtrate to obtain 11 parts of a fluid extract with a specific gravity of 1.3 for later use;
(2) weighing 40 parts of xanthan gum, adding water to soak and dissolve, and obtaining a colloidal solution for later use after swelling or complete dissolution;
(3) weighing 100 parts of honey, 50 parts of milk powder, 5 parts of malic acid, 5 parts of lactic acid, 10 parts of fructo-oligosaccharide, 1 part of aspartame and 0.1 part of potassium sorbate, adding water for dissolving, and heating to obtain syrup for later use;
(4) and (3) combining the fluid extract, the colloidal solution and the syrup prepared in the steps (1), (2) and (3), adding water to the total weight of 1500 parts, uniformly mixing, filtering, sterilizing, and subpackaging 15 parts per bag to obtain the traditional Chinese medicine composition.
Example 4
(1) Weighing the following raw materials in parts by weight: 2000 parts of poria cocos, 1100 parts of coix seeds, 1300 parts of scorched hawthorn fruits, 300 parts of kudzu roots and 20 parts of phaseolus calcaratus are respectively decocted with water for 3 times, the water adding amount is 6 times of the weight of the raw materials each time, the extracting solution is filtered, the filtrate of the raw materials is combined and concentrated into an extract with the relative density of 1.25, ethanol is added to ensure that the alcohol content is 65%, the mixture is kept stand for 24 hours and then filtered, and 20 parts of fluid extract with the specific gravity of 1.3 is obtained after the filtrate is concentrated for later use;
(2) weighing 40 parts of carrageenan and 10 parts of konjac flour, adding water, soaking and dissolving, and obtaining a colloidal solution for later use after swelling or complete dissolution;
(3) weighing 300 parts of xylitol, 10 parts of trehalose, 1 part of potassium chloride, 2 parts of citric acid, 1 part of aspartame, 0.3 part of sorbic acid and 1 part of essence, adding water for dissolving, and heating to obtain syrup for later use;
(4) and (3) combining the fluid extract, the colloidal solution and the syrup prepared in the steps (1), (2) and (3), adding water to the total weight of 1500 parts, uniformly mixing, filtering, sterilizing, and subpackaging 15 parts per bag to obtain the traditional Chinese medicine composition.
Example 5
(1) Weighing the following raw materials in parts by weight: 1400 parts of poria cocos, 1200 parts of coix seeds, 1500 parts of scorched hawthorn fruits, 450 parts of kudzuvine roots and 30 parts of phaseolus calcaratus are respectively decocted with water for 3 times, the water adding amount is 6 times of the weight of the raw materials each time, the time is 1.5 hours each time, the extracting solution is filtered, the filtrate of the raw materials is combined and concentrated into an extract with the relative density of 1.25, ethanol is added to ensure that the alcohol content is 65%, the mixture is kept stand for 24 hours and then filtered, and 18 parts of fluid extract with the specific gravity of 1.3 is obtained after the filtrate is concentrated for later use;
(2) weighing 50 parts of gelatin, adding water to soak and dissolve the gelatin, and obtaining a colloidal solution for later use after swelling or complete dissolution;
(3) weighing 1 part of sucralose, 0.3 part of potassium sorbate, 5 parts of sodium citrate, 5 parts of potassium citrate and 50 parts of fruit juice, adding water for dissolving, and heating to obtain syrup for later use;
(4) and (3) combining the fluid extract, the colloidal solution and the syrup prepared in the steps (1), (2) and (3), adding water to the total weight of 1500 parts, uniformly mixing, filtering, sterilizing, and subpackaging 15 parts per bag to obtain the traditional Chinese medicine composition.
Example 6
(1) Weighing the following raw materials in parts by weight: 1400 parts of poria cocos, 1200 parts of coix seeds, 1500 parts of scorched hawthorn fruits, 450 parts of kudzuvine roots and 30 parts of phaseolus calcaratus are respectively decocted with water for 3 times, the water adding amount is 6 times of the weight of the raw materials each time, the time is 1.5 hours each time, the extracting solution is filtered, the filtrate of the raw materials is combined and concentrated into an extract with the relative density of 1.25, ethanol is added to ensure that the alcohol content is 65%, the mixture is kept stand for 24 hours and then filtered, and 18 parts of fluid extract with the specific gravity of 1.3 is obtained after the filtrate is concentrated for later use;
(2) weighing 30 parts of carrageenan, 5 parts of maltodextrin and 10 parts of konjac flour, adding water, soaking and dissolving, and obtaining a colloidal solution for later use after swelling or complete dissolution;
(3) weighing 60 parts of trehalose, 1 part of sucralose, 0.3 part of potassium sorbate, 1 part of sodium citrate, 1 part of potassium citrate, 1 part of lactic acid, 1 part of malic acid, 0.5 part of potassium chloride, 20 parts of milk powder, 0.5 part of essence and 20 parts of fruit juice, adding water to dissolve, and heating to obtain syrup for later use;
(4) and (3) combining the fluid extract, the colloidal solution and the syrup prepared in the steps (1), (2) and (3), adding water to the total weight of 1500 parts, uniformly mixing, filtering, sterilizing, and subpackaging 15 parts per bag to obtain the traditional Chinese medicine composition.
Comparative example
Weighing the following raw materials in parts by weight: 1500 parts of poria cocos, 1250 parts of coix seeds, 1250 parts of scorched hawthorn fruits, 20 parts of phaseolus calcaratus and 10 parts of rush, and the poria cocos, the coix seeds, the scorched hawthorn fruits, the phaseolus calcaratus and the rush are boiled in water for three times, 8 times of water is added for the first time, the boiling time is 2 hours, 6 times of water is added for the second time, the boiling time is 1.5 hours, 6 times of water is added for the third time, and the boiling time is 1 hour. Mixing the filtrates, adding ethanol until the ethanol content is 70%, standing, concentrating the filtrate to obtain soft extract, adding sucrose, and making into granule.
The product advantages of the invention were verified by the following tests: the test conditions were as follows.
Test example 1 ranking test method to assess the likeness of two different products
The order of preference of the oral gel prepared in example 2 and the granules prepared in comparative example was evaluated by the rank order test.
The experimental method comprises the following steps: and evaluating the favorite sequence of the two products by adopting a sequencing test method.
Sample preparation and sample presentation: in a sequencing test assessment test, two different samples are presented simultaneously to an evaluator who is asked to indicate the degree of preference for each sample.
Sensory evaluation of the samples: before the appraiser checks, the appraiser rinses the mouth with clean water, spits the water into a container prepared in advance, receives two coded samples, please taste the samples from left to right according to the presentation sequence, rinses the mouth with clean water in the middle, please fill the codes of the samples in the table according to the preference degree from dislike to like.
The evaluation results are shown in table 1.
TABLE 1 taste preference degree table for two products
The results show that: the oral gel prepared in example 2 is most preferred.
Test example 2 order test method for evaluating the degree of convenience of use of two different products
The order of convenience of use of the oral gel prepared in example 2 and the granules prepared in comparative example was evaluated by the rank order test.
The experimental method comprises the following steps: the order of convenience of use of the two products was assessed by a sequencing test.
Sample preparation and sample presentation: in a sequencing test assessment test, two different samples are presented simultaneously to an evaluator who is asked to indicate the degree of preference for each sample.
Evaluation of the ease of use of the sample: both samples were distributed to the experimenters and used interchangeably, example 2 ready to eat by tearing open the bag. The comparative example is poured into a paper cup, and hot water is added for dissolution, and the medicine is taken after the water temperature is reached. Filling the code of the sample into the table according to the convenience degree of taking from inconvenience to convenience.
The evaluation results are shown in table 2.
TABLE 2 two products using convenience degree table
The results show that: the product prepared in example 2 is considered most convenient to use.
Test example 3 efficacy assessment of weight control of two products
First, experiment method
The test personnel: a total of 60, randomly divided into 2 groups of 30 people each.
Diagnostic criteria:
the height is 160cm, and the weight is over 70 kg. And voluntarily received the subject as the observation target.
The judgment standard of the curative effect is as follows: the method has the following advantages: the weight loss is less than 5 kg; and (4) invalidation: no improvement in body weight.
The dose is as follows: the product prepared in example 2, usage amounts: it is administered orally 3 times a day in 2 bags.
Comparative example particles, usage amounts: it is administered orally 3 times a day in 2 bags.
Second, clinical curative effect
The results of the two groups of examples after 28 days of treatment are shown in Table 3.
Table 3 table of weight change of two products
The results show that two thirds of the people in example 2 had a tendency to lose weight and the comparative example had no effect on weight control. Experiments prove that the weight control effect of the product prepared in the example 2 is best.
Test example 4 evaluation of efficacy of two products for improving symptoms after drunkenness
The order of the effect of the product of example 2 and the comparative example granules on the improvement of post-inebriation symptoms was evaluated by the rank test method.
The experimental method comprises the following steps: the effect sequence of the two products for improving the symptoms after drunkenness is evaluated by a sequencing test method.
Sample preparation and sample presentation: in the sequencing test assessment test, 2 different samples were presented simultaneously to the evaluator, who was asked to indicate the degree of effect of each sample after the improvement in intoxication.
Evaluation of the ease of use of the sample: a person who is easy to have hangover symptoms after drinking is selected. 2 samples were distributed to the experimenters and used interchangeably. After drinking, the patient takes the wine once, 2 bags each time, and fills the table with the sample codes according to the improvement of the drunk degree from invalid to valid.
The evaluation results are shown in table 4.
Table 4 hangover relief for two products
The results show that example 2 has a significant effect of improving the post-hangover symptoms. Can relieve uncomfortable symptoms after hangover, such as dizziness, nausea, emesis, etc.
Test example 5 evaluation of the efficacy of two products in lowering blood lipid index
First, experiment method
The test personnel: the age is 41-76 years, and the average age is 61.42 + -3.61 years. 40 men and 20 women, 60 in total, were randomized into 2 groups of 30 persons each, and the product prepared in example 2 and the product prepared in comparative example were administered separately.
Inclusion criteria were: meeting the clinical diagnosis standard of fatty liver and hyperlipemia; secondly, the diagnosis is confirmed by combining the detection of physical signs, symptoms, pathology and the like; exclusion criteria: combining dysfunction of other organs (such as heart, lung and the like); ② combining malignant tumors; ③ taking the lipid-lowering medicine within 3 months; fourthly, combining immune or infectious diseases; fifthly, merging the pregnancy or lactation period.
Observation indexes are as follows: the blood lipid levels before and after treatment were compared in two groups. The blood lipid index includes Triglyceride (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C) and Total Cholesterol (TC).
The dose is as follows: the product of example 2. The usage and dosage are as follows: it is administered orally 3 times a day in 2 bags.
Comparative example particles. The usage and dosage are as follows: it is administered orally 3 times a day in 2 bags.
Second, clinical curative effect
The results of the treatment effect of the two groups of products after 30 days are shown in the table 5.
TABLE 5 blood lipid index of two products
Triglyceride (TG), Total Cholesterol (TC), low density lipoprotein (LDL-C) values were all lower than the comparative examples in example 2, with statistical differences (P < 0.05). The blood lipid lowering effect of example 2 is significantly better than that of the comparative example.
Test example 6 damp-clearing heat-clearing and stomach-invigorating effect test
First, research scheme
The product of example 2. The usage and dosage are as follows: it is administered orally 3 times a day in 2 bags.
Comparative example particles. The usage and dosage are as follows: it is administered orally 3 times a day in 2 bags.
Second, Experimental methods
The test personnel: a total of 60 patients were randomized to 30 treatment groups and 30 control groups, and the product prepared in example 2 and the product prepared in comparative example were administered.
Diagnostic criteria: abdominal distention, lassitude, scanty and yellow urine, loose stool, poor appetite, nausea, vomiting and poor sleep; stool is not formed and hair is oily. The subjects were voluntarily accepted as subjects for observation, whenever the above diagnostic criteria were met.
The judgment standard of the curative effect is as follows: the effect is shown: the stool frequency is obviously increased, the shaping is good, the sleep quality is obviously improved, the hair and the skin are not greasy, the appetite is provided, and the sense of fatigue is lost; the method has the following advantages: the symptoms are improved, the stool frequency is increased, the shaping and sleep quality are improved, the hair and skin are not greasy, the appetite is appetized, and the feelings of fatigue are disappeared. And (4) invalidation: symptoms, sleep, energy, etc. are not improved.
Third, clinical curative effect
The results of the treatment of the two groups of cases after 28 days are shown in Table 6.
TABLE 6 evaluation of stomach-invigorating Effect of two products
The comparison of the two groups of treatments shows that the number and effective proportion of the cases in the group of example 2 in the aspects of increasing the stool frequency, improving the stool formation, improving the insomnia, improving the facial greasiness of the hair, improving the appetite and improving the tiredness of the hair are obviously better than those of the comparative example.
The oral gel of the invention has obviously better curative effect than the comparative examples in the aspects of improving damp-clearing spleen-tonifying symptoms, improving symptoms after hangover, controlling body weight, reducing blood fat index and the like. And compared with the comparative example, the product has the advantages of good taste and convenient carrying.
Finally, it is noted that the above-mentioned preferred embodiments illustrate rather than limit the invention, and that, although the invention has been described in detail with reference to the above-mentioned preferred embodiments, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the scope of the invention as defined by the appended claims.
Claims (8)
1. An oral gel for eliminating dampness, invigorating stomach and improving immunity is characterized in that: the oral gel comprises the following raw materials in parts by weight: 1000 portions of tuckahoe, 1500 portions of coix seed, 1000 portions of scorched hawthorn, 500 portions of kudzuvine root, and 10 to 30 portions of phaseolus calcaratus.
2. The oral gel for eliminating dampness, invigorating stomach and improving immunity according to claim 1, wherein: the oral gel for clearing damp, invigorating stomach and improving immunity further comprises the following raw materials in parts by weight: 5-50 parts of rubber powder, 1-400 parts of sweetening agent, 0.1-1.5 parts of preservative, 0.5-10 parts of pH regulator and 0.5-50 parts of flavoring agent.
3. The oral gel for eliminating dampness, invigorating stomach and improving immunity according to claim 2, wherein: the gelatine powder is one or more of carrageenan, xanthan gum, gelatin, konjac flour and maltodextrin.
4. The oral gel for eliminating dampness, invigorating stomach and improving immunity according to claim 2, wherein: the sweetener is one or more of sucrose, xylitol, honey, sucralose, aspartame, fructo-oligosaccharide and trehalose.
5. The oral gel for eliminating dampness, invigorating stomach and improving immunity according to claim 2, wherein: the preservative is one or more of sorbic acid and potassium sorbate.
6. The oral gel for eliminating dampness, invigorating stomach and improving immunity according to claim 2, wherein: the pH regulator is one or more of malic acid, citric acid, lactic acid, sodium citrate, potassium citrate and potassium chloride.
7. The oral gel for eliminating dampness, invigorating stomach and improving immunity according to claim 2, wherein: the flavoring agent is one or more of milk powder, essence and fruit juice.
8. The method for preparing oral gel for eliminating dampness, invigorating stomach and improving immunity according to any one of claims 1 to 5, characterized in that: the method comprises the following steps: (1) weighing the raw traditional Chinese medicines according to the parts by weight, decocting the raw traditional Chinese medicines with water for 3 times respectively, each time lasting for 1.5 hours, filtering the extracting solution, combining the filtrates of the raw traditional Chinese medicines, concentrating into an extract with the relative density of 1.25, adding ethanol to ensure that the ethanol content is 65%, standing for 24 hours, filtering, concentrating the filtrate to obtain a fluid extract with the specific gravity of 1.3 for later use;
(2) weighing the rubber powder according to the weight parts, adding water to soak and dissolve, and obtaining a colloidal solution for later use after swelling or complete dissolution;
(3) weighing a sweetening agent, a preservative, a flavoring agent and a pH regulator according to parts by weight, adding water for dissolving, and heating to obtain syrup for later use;
(4) and (3) mixing the fluid extract, the colloidal solution and the syrup prepared in the steps (1), (2) and (3), adding water to the total weight of 1500 parts, uniformly mixing, filtering, sterilizing and subpackaging to obtain the traditional Chinese medicine.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115381876A (en) * | 2022-09-09 | 2022-11-25 | 云南植物药业有限公司 | Oral preparation for relaxing heart and reducing fat and preparation method thereof |
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