CN114191325A - Plant sunscreen composition and preparation method of nanoparticles thereof - Google Patents

Abstract

The invention relates to the field of cosmetics, in particular to a plant sunscreen composition and a preparation method of nanoparticles thereof; screening natural plant extracts with extremely high extinction coefficients, and reasonably designing and combining to form a sunscreen agent capable of absorbing UVA and UVB simultaneously; in order to further improve the sun-screening effect and the skin feel, the polymer nanoparticles form association according to the characteristics of molecular structures, and are coprecipitated in water to finally form stable nanoparticles, so that the polymer nanoparticles have a good sun-screening effect.

Description

Plant sunscreen composition and preparation method of nanoparticles thereof

Technical Field

The invention belongs to the field of cosmetics, and particularly relates to a plant sunscreen composition and a preparation method of nanoparticles thereof.

Background

Effect of ultraviolet light on skin:

ultraviolet (UV) refers to electromagnetic waves with a wavelength of 10-400nm, accounting for about 7% of the total energy of the solar spectrum. Ultraviolet rays can be divided into three regions, i.e., long-wave ultraviolet rays (UVA), medium-wave ultraviolet rays (UVB), and short-wave ultraviolet rays (UVC), according to their effects on human skin. The UVA wave band is 400-320nm, has strong penetrating power and can directly reach the dermis layer of the skin, so that the skin can become black spots; the UVB wave band is 320-280nm, has medium penetrating power, only less than 2 percent of the UVB wave band can reach the ground, and the UVB wave band can cause skin erythema and is a key protection wave band; the UVC band is 280-200nm, the penetrating power is very weak, and the UVC band is almost completely absorbed by the ozone layer.

The ultraviolet radiation with long time or high intensity can cause photobiological damage to the skin, mainly including erythema solaris, solarization and darkening, photosensitive dermatosis, skin photoaging and even skin tumor. Therefore, people pay attention to sun protection (namely, skin photodamage caused by ultraviolet irradiation is reduced), and sun protection skin care products become necessary products for outdoor sports or traveling.

The sunscreen cosmetics on the market are various in types and brands, but can be divided into two main types, namely physical sunscreen and organic chemical sunscreen according to sunscreen functional components. The physical sunscreen cosmetic contains nanoparticles TiO2 or ZnO as sunscreen component, and can reduce the damage of ultraviolet rays to skin by the absorption, scattering and reflection of ultraviolet rays. Physical sunscreen cosmetics, especially sunscreen cream with a high sun protection coefficient, are greasy, poor in skin feel after use, white in skin, attractive in appearance, prone to cause pore blockage if cleaned improperly, prone to influence secretion of sebaceous glands and sweat glands, and even prone to induce acne and pimples. The organic chemical sunscreen cosmetic mainly contains p-aminobenzoic acid (PAPB) derivatives, anthranilate derivatives, salicylates, cinnamates, benzophenone compounds and the like, and has high ultraviolet absorption capacity and can convert the ultraviolet light quantity absorbed by the organic chemical sunscreen cosmetic into molecular vibration heat energy, so that the damage of ultraviolet rays to skin is reduced. The organic chemical sunscreen skin care product can be absorbed by skin after being used, has good skin feel, but easily stimulates the skin to cause skin allergy. Furthermore, the safety of some organic sunscreens is still controversial.

Due to the defects of discomfort or unsafety and the like of the traditional sunscreen skin care product, the characteristics of good sunscreen effect, good skin feel, small irritation and the like become hot spots for developing the sunscreen skin care product. The ultraviolet rays in the sunlight have strong destructive effect on the organisms, and are no exception to plants. Plants generally absorb ultraviolet rays from sunlight by synthesizing chlorophyll, carotenoid, flavone, and other compounds, and convert them into heat energy or other energy. Thus, compounds capable of absorbing ultraviolet rays in plants can be separated and made into plant sunscreen agents.

Disclosure of Invention

In view of the above problems, the present invention provides a plant sunscreen composition and a method for preparing nanoparticles thereof.

In order to realize the purpose of the invention, the invention adopts the following technical scheme:

a plant sunscreen composition comprises, by mass, 10-30% of mangiferin and 70-90% of chrysin, rhapontigenin or a combination of the two.

Furthermore, the composition comprises 20% of mangiferin, 70% of rhapontigenin and 10% of chrysin according to the mass ratio.

A method of preparing nanoparticles of a plant sunscreen composition comprising the steps of:

(1) melting raw materials by using polyhydric alcohol under the heating condition;

(2) adding cold water into the mixed solution, and stirring at high speed or homogenizing;

(3) filtering and aging;

(4) centrifuging and collecting bottom mud.

Further, the polyol described in step 1 is a high boiling point polyol.

Further, the heating melting temperature in the step 1 is 60-150 ℃.

Further, the high boiling point polyol is PEG-400 or butanediol.

Further, the heating melting temperature in the step 1 is 95-105 ℃.

A method of preparing nanoparticles of a plant sunscreen composition comprising the steps of:

(1) weighing 70g of rhaponticum carthamoides emodin, 20g of chrysin and 10g of mangiferin in a beaker;

(2) adding 150mL of polyethylene glycol-400 into a beaker, and stirring and uniformly mixing by using a glass rod;

(3) placing the beaker on an electric hot plate, heating to 100 ℃, and melting and dissolving the materials;

(4) adding 500mL of pure water into the beaker, and stirring for 15min by using a high-speed stirrer;

(5) filtering the suspension by a 200-mesh screen to remove large-particle impurities in the raw materials;

(6) the suspension was left to age for 24h and after centrifugation at 3000G, approximately 250G of bottom sludge was collected.

By adopting the technical scheme, the invention has the advantages that:

the ultraviolet absorbent provided by the invention is prepared from natural plant extracts, has UVB and UVA protection functions, and does not need to be additionally added with an organic synthetic ultraviolet absorbent or a mineral ultraviolet absorbent.

When the rhaponticum carthamoides emodin and the chrysin or mangiferin are blended, the solubility of the rhaponticum carthamoides emodin and the chrysin or mangiferin in polyhydric alcohol is improved, and coprecipitation is favorably formed in water to form nano particles.

The invention can prepare the natural plant extract into nano particles which can be suspended in water, thereby not only enhancing the sun-screening effect, but also being directly used as an aqueous sun-screening agent and improving the skin feel of the product.

Description of the drawings:

FIG. 1 is a molecular structure diagram and an absorption spectrum diagram of chrysin;

FIG. 2 is a molecular structure diagram and an absorption spectrum diagram of mangiferin;

FIG. 3 is a molecular structure diagram and an absorption spectrum diagram of rhapontigenin;

FIG. 4 is a graph showing an ultraviolet absorption spectrum of example 1;

FIG. 5 is the particle size distribution of the starting material of example 1 (D50 ═ 9.26 nm);

FIG. 6 is the particle size distribution (D50 ═ 0.705nm) of the starting material of example 4 (comparative experiment);

fig. 7 is the particle size distribution (D50 ═ 0.197nm) for the samples of example 1.

Detailed Description

The present invention is further illustrated by the accompanying fig. 1-7 and the detailed description, which describe only some embodiments of the invention and do not limit the content of the invention. Other embodiments, which can be made by persons skilled in the art without any inventive contribution, fall within the scope of protection of the present invention.

A plant sunscreen composition comprises, by mass, 10-30% of mangiferin and 70-90% of chrysin, rhapontigenin or a combination of the two.

A method of preparing nanoparticles of a plant sunscreen composition comprising the steps of:

(1) melting raw materials by using polyhydric alcohol under the heating condition;

(2) adding cold water into the mixed solution, and stirring at high speed or homogenizing;

(3) filtering and aging;

(4) centrifuging and collecting bottom mud.

The following is further detailed by specific examples:

example 1

(1) Weighing 70g of rhaponticum carthamoides emodin, 20g of chrysin and 10g of mangiferin in a beaker;

(2) adding 150mL of polyethylene glycol-400 into a beaker, and stirring and uniformly mixing by using a glass rod;

(3) placing the beaker on an electric hot plate, heating to 100 ℃, and melting and dissolving the materials;

(4) adding 500mL of pure water into the beaker, and stirring for 15min by using a high-speed stirrer;

(5) filtering the suspension by a 200-mesh screen to remove large-particle impurities in the raw material seeds;

(6) the suspension was left to age for 24h and after centrifugation at 3000G, approximately 250G of bottom sludge was collected.

Example 2

(1) Weighing 65g of rhaponticum carthamoides, 20g of chrysin and 15g of mangiferin in a beaker;

(2) adding 100mL of 1, 3-butanediol and 50mL of glycerol into a beaker, and uniformly stirring by using a glass rod;

(3) placing the beaker on an electric heating plate, heating to 95 ℃, and melting and dissolving the materials;

(4) adding 400mL of pure water into the beaker, and stirring for 20min by using a high-speed stirrer;

(5) filtering the suspension by a 200-mesh screen to remove large-particle impurities in the raw material seeds;

(6) the suspension was left to age for 24h and after centrifugation at 3000G, about 240G of bottom sludge was collected.

Example 3

A sunscreen lotion of plant sunscreen composition has the following formula.

TABLE 1 formulation of Natural sunscreen

Ingredients	Proportioning	Remarks for note
			Pure water	Balance of	Dispersion medium
Example 1	30％	Ultraviolet absorber
			Coconut oil acyl potassium glycinate	3.0％	Emulsifier
Decaglycerol monostearate	1.0％	Emulsifier
			Carbomer	0.3％	Thickening agent
Xanthan gum	0.2％	Thickening agent
			P-hydroxyacetophenone	0.2％	Preservative
Octanoyl hydroximic acid	0.05％	Preservative

The sunscreen emulsion has a sunscreen index of 16 for UVB and a sunscreen strength of PA + + +, for UVA.

Example 4 (comparative example 1)

(1) Weighing 100g of the danesexperidin in a beaker;

(2) adding 150mL of polyethylene glycol-400 into a beaker, and stirring and uniformly mixing by using a glass rod;

(3) placing the beaker on an electric hot plate, heating to 100 ℃, and melting and dissolving the materials;

(4) adding 500mL of pure water into the beaker, and stirring for 15min by using a high-speed stirrer;

(5) filtering the suspension with 200 mesh screen to remove large particle impurities (form large particle crystals);

(6) the suspension was left to age for 24h and after centrifugation at 3000G approximately 210G of bottom sludge was collected.

To demonstrate the effectiveness of the present invention, the inventors used an ultraviolet spectrophotometer (UV-1780) to determine the ultraviolet absorption spectrum and extinction coefficient of the sample; measuring the particle size distribution of the sample by using a laser particle size analyzer (BT-9300S); the protection against SPF and UVA was determined using UV-2000. The results of the measurement were as follows:

FIG. 1 shows the molecular structure and absorption spectrum of chrysin

E(1％,1cm,269nm)＝1485

E(1％,1cm,269nm)＝657

Absorb mainly UVC and part UVB

FIG. 2 shows molecular structure diagram and absorption spectrum diagram of mangiferin

E(1％,1cm,317nm)＝490

E(1％,1cm,365nm)＝306

(absorbing both UVA and part of UVB')

FIG. 3 shows molecular structure diagram and absorption spectrum diagram of emodin

E(1％,1cm,319nm)＝1197

Absorption of predominantly UVB

FIG. 4 ultraviolet absorption spectrum of example 1

Covering UVB and UVA

FIG. 5 particle size distribution of the starting material of example 1 (D50 ═ 9.26nm)

FIG. 6 particle size distribution of the starting material of example 4 (comparative experiment) (D50 ═ 0.705nm)

Fig. 7 particle size distribution of the sample of example 1 (D50 ═ 0.197 nm).

While the foregoing description shows and describes the preferred embodiments of the present invention, it is to be understood that the invention is not limited to the forms disclosed herein, but is not to be construed as excluding other embodiments and is capable of use in various other combinations, modifications, and environments and is capable of changes within the scope of the inventive concept as described herein, commensurate with the above teachings, or the skill or knowledge of the relevant art. And that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (8)

1. A plant sunscreen composition characterized by: the composition of mangiferin and one or two of chrysin and rhapontigenin is characterized in that according to the mass ratio, the mangiferin accounts for 10-30%, and the chrysin or rhapontigenin or the combination of the chrysophanol and the rhapontigenin accounts for 70-90%.

2. A plant sunscreen composition according to claim 1 wherein: the composition comprises, by mass, 20% of mangiferin, 70% of rhapontigenin and 10% of chrysin.

3. A method for preparing nanoparticles of a plant sunscreen composition, comprising: the method comprises the following steps:

(1) melting raw materials by using polyhydric alcohol under the heating condition;

(2) adding cold water into the mixed solution, and stirring at high speed or homogenizing;

(3) filtering and aging;

(4) centrifuging and collecting bottom mud.

4. A method of preparing nanoparticles of a plant sunscreen composition as claimed in claim 3, wherein: the polyol described in step 1 is a high boiling point polyol.

5. A method of preparing nanoparticles of a plant sunscreen composition as claimed in claim 3, wherein: the heating melting temperature in the step 1 is 60-150 ℃.

6. A method of making nanoparticles of a plant sunscreen composition as claimed in claim 4, wherein: the high boiling point polyol is PEG-400 or butanediol.

7. A method of making nanoparticles of a plant sunscreen composition as claimed in claim 5, wherein: the heating melting temperature in the step 1 is 95-105 ℃.

8. A method for preparing nanoparticles of a plant sunscreen composition, comprising: the method comprises the following steps:

(1) weighing 70g of rhaponticum carthamoides emodin, 20g of chrysin and 10g of mangiferin in a beaker;

(2) adding 150mL of polyethylene glycol-400 into a beaker, and stirring and uniformly mixing by using a glass rod;

(3) placing the beaker on an electric hot plate, heating to 100 ℃, and melting and dissolving the materials;

(4) adding 500mL of pure water into the beaker, and stirring for 15min by using a high-speed stirrer;

(5) filtering the suspension by a 200-mesh screen to remove large-particle impurities in the raw materials;

(6) the suspension was left to age for 24h and after centrifugation at 3000G, approximately 250G of bottom sludge was collected.

Images