CN1141784A - Anti-cancer medicine and preparation method thereof - Google Patents

Abstract

The present invention relates to a Chinese medicine with anticancer function, which has two different prescriptions, i.e. No.1 prescription and No.2 prescription. The medicinal materials are pretreated and proportioned, and divided into two groups, and the medicinal materials of one group are pulverized, and the medicinal materials of another group are decocted and concentrated, then the medicines of two groups are mixed, dried, pulverized, granulated, dried and packaged so as to obtain the invented product. Said invention mainly can be used for curing nasopharyngeal carcinoma, carcinoma of uterus, prostatic carcinoma, mammary cancer and cancer of lung, etc..

Description

A kind of PTS-" executing rehabilitation " and preparation method thereof

The present invention relates to a kind of Chinese medicine and preparation method thereof, specifically be meant new Chinese medicine-" executing rehabilitation " and preparation technology thereof with antitumaous effect.

At present, mainly adopt the operation, chemicals, radioactivity, immune formulation of doctor trained in Western medicine etc. in the method for medical circle treatment malignant tumor, wherein best with " early stage original position focus radical correction " effect, but Most patients but spreads already, dies also to be aided with after operation usually and carry out chemotherapy, radiotherapy, immunization therapy if find its original position focus by the time.Chemotherapeutant is " protoplasmic poison " agent mostly, and side effect is big, and patient often is difficult to stand, and these medicines inhibitory action concerning exhausted most tumor, prolongs band tumor life span, and does not reach the purpose of radical cure; Radiation treatment can kill perilesional normal cell equally, make damaged part be difficult to recover, and the character of tumor, degree, happening part and the scope of being invaded is different, and radiotherapy is very restricted, and effect is not ideal; And the immunization therapy poor specificity, uncertain therapeutic efficacy is cut.And the Chinese traditional treatment malignant tumor is of long standing and well established, definite effect, but because the traditional Chinese medical science does not have for sorting technique, name, diagnosis basis, the efficacy assessment standard of tumor and the method and the standard of doctor trained in Western medicine are linked up, particularly the traditional Chinese medical science is proved the diagnosis index that lacks modern science in the diagnosis and treatment process of malignant tumor, so the achievement of Chinese traditional treatment malignant tumor is not for a long time accepted by doctor trained in Western medicine circle.The person interested to the Chinese medicine is arranged in the doctor trained in Western medicine, also have in the traditional Chinese medical science and be ready to accept the modern medicine operator, malignant cell is had directly kill or inhibiting Chinese herbal medicine but these philtrum great majority are laid particular stress on screening, and ignored complex physical in tumor generation, the evolution, the caused many organs of pathological change, the unbalance serious harm that causes of too many levels, that is to say basic norm-organic conception of having ignored Chinese traditional treatment.

The purpose of this invention is to provide and a kind of QI invigorating is consolidated medicine, drug for invigorating blood circulation and eliminating stasis, eliminating evil antidote by monarch, minister, the principles of formulating prescriptions helping, make, the PTS of the uniformity of medical knowledge, method, side, medicine in embodying-" executing rehabilitation " and preparation method thereof.

The compositions that the present invention " executes rehabilitation " has two different prescriptions, i.e. I side and II sides:

I side comprises: (total amount is 245) Radix Astragali 10-30, Radix Codonopsis 10-30, Rhizoma Atractylodis Macrocephalae 10-20, Poria 10-20, Radix Glehniae 10-30, Radix Rehmanniae Preparata 5-20, Rhizoma Polygonati 5-20, Spina Gleditsiae 10-20, Fructus Ligustri Lucidi 10-30, Herba Leonuri 10-20, Radix Paeoniae Alba 5-20, Fructus Corni 5-20, Rhizoma Corydalis 5-20, (system) Rhizoma Cyperi 5-20, Radix Clematidis 5-20, Radix Notoginseng 3-20, Radix Puerariae 5-20, Radix Paeoniae Rubra 5-20, Radix Salviae Miltiorrhizae 5-20, Radix Aconiti 3-15, Rhizoma Cimicifugae 3-15, Rhizoma Pinelliae Preparatum 3-15, Radix Et Rhizoma Rhei 3-15, Herba Ecliptae 10-20, Radix Angelicae Sinensis 5-20;

II side comprises: (total amount is 160) Radix Sophorae Tonkinensis 10-30, Rhizoma Paridis 10-30, Herba Hedyotidis Diffusae 10-30, Herba Scutellariae Barbatae 10-30, Radix Trichosanthis 10-30, Herba Agrimoniae 10-30, Radix Arnebiae (Radix Lithospermi) 5-25, Sargassum 5-25, (stir-fry) Semen Lepidii (Semen Descurainiae) 5-25, (stir-fry) Semen Sinapis 5-25, (stir-fry) Semen Vaccariae 5-25, Concha Ostreae 5-25, ground beetle 5-25, (system) Olibanum 3-25, (system) Myrrha 3-25, rhizoma sparganic 10-20, Rhizoma Curcumae 10-20.

The preparation method of above-mentioned two kinds of prescriptions all adopts: with medical material pretreatment and batching, and it is divided into two groups, pulverizes for one group, another group needs to decoct and concentrates, two groups of medicines is mixed again, dry and pulverizing, granulation, drying, is packaged as finished product at last.

Below, reach embodiment in conjunction with the accompanying drawings a kind of PTS of the present invention-" executing rehabilitation " composition and method of making the same is described in detail.

Fig. 1 is a kind of PTS of the present invention-" executing rehabilitation " preparation of compositions process chart;

Fig. 2 is preparation technology's flow chart of a kind of PTS of the present invention-" executing rehabilitation " composition I side;

Fig. 3 is preparation technology's flow chart of a kind of PTS of the present invention-" executing rehabilitation " composition I I side.

Embodiment 1:

The I side of compositions that a kind of PTS of the present invention " is executed rehabilitation " comprises: (total amount is 245) Radix Astragali 20, Radix Codonopsis 10, the Rhizoma Atractylodis Macrocephalae 10, Poria 10, Radix Glehniae 10, Radix Rehmanniae Preparata 10, Rhizoma Polygonati 10, Spina Gleditsiae 5, Fructus Ligustri Lucidi 10, Herba Leonuri 10, the Radix Paeoniae Alba 10, Fructus Corni 10, Rhizoma Corydalis 10, (system) Rhizoma Cyperi 10, Radix Clematidis 10, Radix Notoginseng 10, Radix Puerariae 10, Radix Paeoniae Rubra 10, Radix Salviae Miltiorrhizae 10, Rhizoma Cimicifugae 5, Radix Aconiti 5, Rhizoma Pinelliae Preparatum 10, Radix Et Rhizoma Rhei 10, Herba Ecliptae 10, Radix Angelicae Sinensis 10;

II side comprises: (total amount is 160)

Radix Sophorae Tonkinensis 10, Rhizoma Paridis 10, Herba Hedyotidis Diffusae 10, Herba Scutellariae Barbatae 10, Radix Trichosanthis 10, Herba Agrimoniae 10, Radix Arnebiae (Radix Lithospermi) 10, Sargassum 10, (stir-fry) Semen Lepidii (Semen Descurainiae) 10, (stir-fry) Semen Sinapis 10, (stir-fry) Semen Vaccariae 10, Concha Ostreae 10, ground beetle 10, (system) Olibanum 5, (system) Myrrha 5, rhizoma sparganic 10, Rhizoma Curcumae 10.

Preparation technology's method of I side is: (referring to Fig. 1, Fig. 2)

1, pre-treatment of raw material and batching:

Side's Chinese crude drug is concocted or is handled according to Chinese Pharmacopoeia nineteen ninety version and " Hunan Province's Chinese crude drug concocted specification ", accurately weighs supplementary material by side's amount then and checks.

2, pulverize:

Get Radix Et Rhizoma Rhei, Fructus Corni and put under low temperature (60 ℃) condition dryly, pulverize separately in Radix Notoginseng, Rhizoma Pinelliae Preparatum and Radix Et Rhizoma Rhei, the mountain cornel is become fine powder, mistake 100 mesh sieves are standby.

3, decoct and concentrate:

Get the medical material except that Radix Et Rhizoma Rhei, Fructus Corni, Radix Notoginseng, Rhizoma Pinelliae Preparatum, adding ten times of recipe quantity decoctings boiled two hours, filtering filtrate for later use, adding octuple recipe quantity decocting in its medicinal residues again boiled one and a half hours, filtering filtrate and front filtrate merge, and make it be concentrated into the extractum that relative density is 1.30～1.35 (63～65 ℃).

4, mix

Get recipe quantity 3% dextrin 2/3 with Radix Notoginseng, Rhizoma Pinelliae Preparatum fine powder mixing, add in the extractum, stir into compound;

5, dry and pulverizing:

Compound is placed vacuum drying oven, and (60 ℃, 90.6～93.3KPa) dry, crushed after being dried become dried cream powder standby;

6, granulate:

Get the abundant mixing of dextrin of dried cream powder and Radix Et Rhizoma Rhei, Fructus Corni fine powder and remaining 1/3, adding 70% ethanol is that wetting agent is made soft material, makes wet granular, is dried to semi-finished product under low temperature (60-80 ℃) condition;

7, packing:

The semi-finished product that make after sampling is carried out every inspection by the quality standard of working out, are packed (every bag of about 5g) with aluminium plastic membrane, get product.

Preparation technology's method of II side is seen Fig. 3;

The Olibanum of II side, Myrrha and ground beetle Radix Et Rhizoma Rhei, Fructus Corni and Radix Notoginseng, the Rhizoma Pinelliae Preparatum with I side respectively are identical, and pulverize separately, to cross 100 mesh sieves standby.

Other medical materials decocting time for the first time are one and a half hours, and the every bag of finished product is pressed the 3.5g packing.

Other technologies and I side are roughly the same.

Embodiment 2.

The similar medicine of the also available nature and flavor of the some drugs of the I of embodiments of the invention 1, II number two kinds of sides substitutes, and can reach curative effect equally.

1, the Radix Astragali in the I side, Radix Codonopsis can be used substituting as Korean Ginseng, Radix Panacis Quinquefolii, Jilin Radix Ginseng, Radix Ginseng etc. of Araliaceae Radix Ginseng and so on, and consumption can reduce, and effect is better, but cost an arm and a leg, the medicine that also available Radix Pseudostellariae, Leptoradix Ginseng, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli etc. contain " ginsenoside " substitutes; With alternative Rhizoma Atractylodis Macrocephalaes such as Rhizoma Atractylodis, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae; Substitute Poria with Polyporus, Rhizoma Smilacis Glabrae; With alternative Radix Notoginseng, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Herba Leonuris etc. such as Semen Persicae, Flos Carthami, Lignum Sappan, (big gun) Squama Manis, Rhizoma Curcumae Longae, Hirudo, Tabanus, Pheretimas; With (system) Rhizoma Arisaematis substitution method Rhizoma Pinelliae; With alternative Rhizoma Polygonatis such as Rhizoma Polygonati Odorati, Radix Ophiopogonis; Substitute Radix Rehmanniae Preparata with the Radix Rehmanniae; Substitute (system) Radix Aconiti with (system) Radix Aconiti Kusnezoffii or (big gun) Radix Aconiti Lateralis Preparata; Substitute Spina Gleditsiae with (stir-fry) Semen Vaccariae.

2, in II side: alternative ground beetles such as available Semen Persicae, Flos Carthami, Hirudo, Tabanus, Pheretima; With Herba Solani Lyrati, Herba Solani Nigri, lose alternative Radix Sophorae Tonkinensis, Rhizoma Paridis, Herba Agrimoniae, Radix Arnebiae (Radix Lithospermi), Sargassums etc. such as facing grass, Fructus Mume, Herba Solidaginis, summer aunt grass.

Embodiment 3:

The component of I of the present invention, II side is interchangeable, as Spina Gleditsiae and (stir-fry) Semen Vaccariae are exchanged, ground beetle and Radix Notoginseng, Radix Paeoniae Rubra is exchanged.

From the prescription of embodiments of the invention, there are Radix Puerariae, Rhizoma Cimicifugae component in its I side, sends out in order to the gas lift of the clear sun of middle Jiao, and all gas of uniting is failed the cloth whole body, has and enriches the meaning of defending gas, the effect of useful gas-solid basis; Its Rhizoma Cyperi, Radix Clematidis component, can make all medicines lead to twelve channels and collaterals, the effect of blood circulation promoting and blood stasis dispelling is arranged; There are Semen Vaccariae, Semen Sinapis Albae, Semen Lepidii (Semen Descurainiae) component in its II side, can draw outside the sensible flesh side film of all medicines, drives straight on to the tumor nest.On technology, adopt Radix Et Rhizoma Rhei, Fructus Corni, Rhizoma Pinelliae Preparatum, Radix Notoginseng, ground beetle, Olibanum, Myrrha need not decocted, only needing to concoct direct pulverizing the in back infiltrates among extractum and the dried cream powder on request respectively, extractum does not need precipitate with ethanol, after the granulation, only needs under low temperature (60～80 ℃) condition dry.

" executing rehabilitation " of the present invention mainly treats nasopharyngeal carcinoma, uterus carcinoma, carcinoma of prostate, breast carcinoma, pulmonary carcinoma etc., also very effective to the malignant tumor of digestive system.

Claims (6)

1, a kind of PTS-" executing rehabilitation " is characterized in that, it has two prescriptions:

-I side comprises: (total amount is 245) Radix Astragali 10-30, Radix Codonopsis 10-30, Rhizoma Atractylodis Macrocephalae 10-20, Poria 10-20, Radix Glehniae 10-30, Radix Rehmanniae Preparata 5-20, Rhizoma Polygonati 5-20, Spina Gleditsiae 10-20, Fructus Ligustri Lucidi 10-30, Herba Leonuri 10-20, Radix Paeoniae Alba 5-20, Fructus Corni 5-20, Rhizoma Corydalis 5-20, (system) Rhizoma Cyperi 5-20, Radix Clematidis 5-20, Radix Notoginseng 3-20, Radix Puerariae 5-20, Radix Paeoniae Rubra 5-20, Radix Salviae Miltiorrhizae 5-10, Radix Aconiti 3-15, Rhizoma Cimicifugae 3-15, Rhizoma Pinelliae Preparatum 3-15, Radix Et Rhizoma Rhei 3-15, Herba Ecliptae 10-20, Radix Angelicae Sinensis 5-20;

-II side comprises: (total amount is 160) Radix Sophorae Tonkinensis 10-30, Rhizoma Paridis 10-30, Herba Hedyotidis Diffusae 10-30, Herba Scutellariae Barbatae 10-30, Radix Trichosanthis 10-30, Herba Agrimoniae 10-30, Radix Arnebiae (Radix Lithospermi) 5-25, Sargassum 5-25, (stir-fry) Semen Lepidii (Semen Descurainiae) 5-25, (stir-fry) Semen Sinapis 5-25, (stir-fry) Semen Vaccariae 5-25, Concha Ostreae 5-25, ground beetle 5-25, (system) Olibanum 3-25, (system) Myrrha 3-25, rhizoma sparganic 10-20, Rhizoma Curcumae 10-20.

2, a kind of PTS-" executing rehabilitation " according to claim 1 is characterized in that:

-I side comprises: (total amount is 245) Radix Astragali 20, Radix Codonopsis 10, the Rhizoma Atractylodis Macrocephalae 10, Poria 10, Radix Glehniae 10, Radix Rehmanniae Preparata 10, Rhizoma Polygonati 10, Spina Gleditsiae 5, Fructus Ligustri Lucidi 10, Herba Leonuri 10, the Radix Paeoniae Alba 10, Fructus Corni 10, Rhizoma Corydalis 10, (system) Rhizoma Cyperi 10, Radix Clematidis 10, Radix Notoginseng 10, Radix Puerariae 10, Radix Paeoniae Rubra 10, Radix Salviae Miltiorrhizae 10, Rhizoma Cimicifugae 5, Radix Aconiti 5, Rhizoma Pinelliae Preparatum 10, Radix Et Rhizoma Rhei 10, Herba Ecliptae 10, Radix Angelicae Sinensis 10;

II side comprises: (total amount is 160) Radix Sophorae Tonkinensis 10, Rhizoma Paridis 10, Herba Hedyotidis Diffusae 10, Herba Scutellariae Barbatae 10, Radix Trichosanthis 10, Herba Agrimoniae 10, Radix Arnebiae (Radix Lithospermi) 10, Sargassum 10, (stir-fry) Semen Lepidii (Semen Descurainiae) 10, (stir-fry) Semen Sinapis 10, (stir-fry) Semen Vaccariae 10, Concha Ostreae 10, ground beetle 10, (system) Olibanum 5, (system) Myrrha 5, rhizoma sparganic 10, Rhizoma Curcumae 10.

3, a kind of PTS-" executing rehabilitation " according to claim 1 and 2 is characterized in that the component of I, II side is interchangeable, as Spina Gleditsiae and (stir-frys) Semen Vaccariae are exchanged, with ground beetle and Radix Notoginseng, Radix Paeoniae Rubra exchange;

4, a kind of PTS according to claim 1 and 2-" Shi Fukang " is characterized in that:

The Radix Astragali of-I side, Radix Codonopsis can substitute with the medicine that contains " ginsenoside " as Korean Ginseng, Radix Panacis Quinquefolii, Jilin Radix Ginseng, Radix Ginseng, Radix Pseudostellariae, Leptoradix Ginseng, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli etc. of Araliaceae Radix Ginseng and so on; With alternative Rhizoma Atractylodis Macrocephalaes such as Rhizoma Atractylodis, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae; Substitute Poria with Polyporus, Rhizoma Smilacis Glabrae; With alternative Radix Notoginseng, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Herba Leonuris etc. such as Semen Persicae, Flos Carthami, Lignum Sappan, (big gun) Squama Manis, Rhizoma Curcumae Longae, Hirudo, Tabanus, Pheretimas; With (system) Rhizoma Arisaematis substitution method Rhizoma Pinelliae; With alternative Rhizoma Polygonatis such as Rhizoma Polygonati Odorati, Radix Ophiopogonis; Substitute Radix Rehmanniae Preparata with the Radix Rehmanniae; Substitute (system) Radix Aconiti with (system) Radix Aconiti Kusnezoffii or (big gun) Radix Aconiti Lateralis Preparata; Substitute Spina Gleditsiae with (stir-fry) Semen Vaccariae.

Ground beetle in the-II side can use Semen Persicae, Flos Carthami, Hirudo, Tabanus, Pheretima etc. to substitute; With Herba Solani Lyrati, Herba Solani Nigri, lose alternative Radix Sophorae Tonkinensis, Rhizoma Paridis, Herba Agrimoniae, Radix Arnebiae (Radix Lithospermi), Sargassums etc. such as facing grass, Fructus Mume, Herba Solidaginis, summer aunt grass.

5, the preparation method of a kind of PTS-" executing rehabilitation ", it is characterized in that its employing: with medical material pretreatment and batching, and it is divided into two groups, pulverize for one group, another group need fry in shallow oil with concentrate, again two groups of medicines mixed, dry with pulverize, granulate, drying, be packaged as finished product at last.

6, the preparation method of a kind of PTS according to claim 5-" executing rehabilitation ", it is characterized in that on technology, adopting Fructus Corni, Rhizoma Pinelliae Preparatum, Radix Notoginseng, ground beetle, Olibanum, Myrrha need not decocted, only needing to concoct direct pulverizing the in back infiltrates among extractum and the dried cream powder on request respectively, extractum does not need precipitate with ethanol, after the granulation, only need under low temperature (60～80 ℃) condition dry.

Images