CN114164370A - Mg-based biological material based on high-entropy alloy theory and preparation method and application thereof - Google Patents

Mg-based biological material based on high-entropy alloy theory and preparation method and application thereof Download PDF

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CN114164370A
CN114164370A CN202111500334.1A CN202111500334A CN114164370A CN 114164370 A CN114164370 A CN 114164370A CN 202111500334 A CN202111500334 A CN 202111500334A CN 114164370 A CN114164370 A CN 114164370A
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马北一
巨东英
杨宏
刘乾
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University of Science and Technology Liaoning USTL
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Abstract

The invention provides a Mg-based biomaterial based on a high-entropy alloy theory, and a preparation method and application thereof, wherein the component expression of the Mg-based biomaterial is MgaZnbSncSrdBieA, b, c, d and e are atomic percentages of the corresponding elements, respectively, wherein: a is more than or equal to 30 and less than or equal to 35, b is more than 0 and less than or equal to 30, c is more than 0 and less than or equal to 30, d is more than 0 and less than or equal to 30, e is more than 0 and less than or equal to 30, and a + b + c + d + e is equal to 100. The Mg-based biomaterial has the elastic modulus of 17.98G/Pa,the melting point is 420 ℃, the hardness is high, the biocompatibility is good, the defects of low strength, high melting point, high processing difficulty, poor elasticity modulus close to human skeleton, uncontrollable degradation speed and the like existing in the aspect of applying Mg metal alloy to medical materials in the prior art can be overcome, and the Mg metal alloy is applied to the field of biomedical materials.

Description

Mg-based biological material based on high-entropy alloy theory and preparation method and application thereof
Technical Field
The invention relates to the technical field of high-entropy and biomedical materials, in particular to an Mg-based biomaterial based on a high-entropy alloy theory, and a preparation method and application thereof.
Background
The biomaterial is a natural or artificial material which can diagnose, treat, repair, and enhance functions of a diseased or damaged organism tissue or organ, and has no adverse effect on the organism. Currently, there are many types of biomaterials that have gained widespread acceptance, such as stainless steel, cobalt-based alloys, Ti and Ti-based alloys, Ta alloys, precious metals, Mg-based alloys, etc. Biomaterials are required to have excellent mechanical properties such as high strength, good ductility, good processability, and excellent corrosion resistance. Mg ions are one of essential elements in the human body, and can be permanently remained in an implant after the organism implantation treatment due to the high similarity of the Mg ions and the human skeleton, so that the necessity of secondary removal operation and subsequent physiological pain and economic burden are avoided. In 2016, the biomedical magnesium alloy research is determined to be one of the key research projects supported by the state in the new material field.
The main objective of this study was to produce Mg-based high entropy biomaterials, the selection of which elements requires consideration of many factors. First, according to the definition of high-entropy alloy, the composition of the high-entropy alloy needs at least 5 elements and more, and the atomic percentage of each element is between 5% and 35%. Meanwhile, in order to better form a solid solution phase in the high-entropy alloy, the atomic size difference is less than or equal to 6.6 percent. Secondly, according to published papers and research results, many metal elements have been used to prepare high entropy alloys and have achieved good results, such as AlCoCrCu FeNi, RhIrPdPt NiCu, (Ag/In/Cd/Sn/Sb/Pb/Bi) -Te, AlCrFeCoNiZn, (Al/Cr/V/Sn) NbTaTiZr, MgAlSiCrFe, MgAlLiZnCaY/AlLiZnCuM, etc. Thirdly, a great deal of research has been conducted in recent years on various biomaterials, particularly Mg-based biomaterials, including elements such as Mg, Zn, Ca, Mn, Nb, Sn, Sr, Bi, Li, Gd, Zr, Ti, etc., and various elements are present in the selection of Mg-based biomaterials.
Mg-based biological materials are becoming the key points of research and development of surgical implants, but the Mg metal alloy in the prior art still has the defects of low strength, high melting point, large processing difficulty, insufficient elastic modulus close to human skeleton, uncontrollable degradation speed and the like when being applied to medical materials.
Disclosure of Invention
The invention provides a Mg-based biomaterial based on a high-entropy alloy theory, and a preparation method and application thereof, and aims to solve the problems of low strength, high melting point, high processing difficulty, insufficient elastic modulus close to human skeleton, uncontrollable degradation speed and the like in the application of the existing Mg-based biomaterial in the aspect of medical materials.
In view of the above-mentioned drawbacks of the prior art, an object of the present invention is to provide a Mg-based biomaterial based on the high-entropy alloy theory, wherein the component expression of the Mg-based biomaterial is MgaZnbSncSrdBieA, b, c, d and e are atomic percentages of the corresponding elements, respectively, wherein: a is more than or equal to 30 and less than or equal to 35, b is more than 0 and less than or equal to 30, c is more than 0 and less than or equal to 30, d is more than 0 and less than or equal to 30, e is more than 0 and less than or equal to 30, and a + b + c + d + e is equal to 100.
It is a further object of the present invention to provide a method for preparing a Mg-based biomaterial.
It is a further object of the present invention to provide the use of the Mg-based biomaterial according to the present invention or the method of the present invention for the preparation of a Mg-based biomaterial.
In order to achieve the purpose, the invention adopts the following technical scheme: in a first aspect, the invention provides a Mg-based biomaterial based on a high-entropy alloy theory, and the ingredient expression of the Mg-based biomaterial is MgaZnbSncSrdBieA, b, c, d and e are atomic percentages of the corresponding elements, respectively, wherein: a is more than or equal to 30 and less than or equal to 35, b is more than 0 and less than or equal to 30, c is more than 0 and less than or equal to 30, d is more than 0 and less than or equal to 30, e is more than 0 and less than or equal to 30And a + b + c + d + e is 100. Preferably, in the Mg-based biomaterial, a is more than or equal to 30 and less than or equal to 35, b is more than 25 and less than or equal to 30, c is more than 25 and less than or equal to 30, d is more than 5 and less than or equal to 7, and e is more than 5 and less than or equal to 7.
Preferably, the Mg-based raw material has the composition expression of Mg30Zn30Sn30Sr5Bi5。
Preferably, the melting point of the Mg-based biomaterial of the invention is 410-430 ℃; preferably 420 deg.c.
Preferably, the Mg-based biomaterial of the present invention has a density of 4.3 to 4.6g/cm3(ii) a Preferably, the elastic modulus of the Mg-based biomaterial is 16-20G/Pa; preferably, the compressive yield strength value of the Mg-based biomaterial is 170-210 MPa; further preferably, the Mg-based biomaterial of the present invention has a density of 4.47g/cm3(ii) a Preferably, the Mg-based biomaterial of the invention has an elastic modulus of 17.98G/Pa; preferably, the compressive yield strength value of the Mg-based biomaterial of the present invention is 192.84 MPa.
In a second aspect, the present invention provides a method of preparing a Mg-based biomaterial, comprising the steps of:
a: preparing a metal raw material according to the component proportion of the Mg-based biomaterial;
b: b, putting the metal raw material in the step B into a bearing container, and smelting in a smelting furnace under a protective atmosphere;
c: and cooling the Mg-based biomaterial in a protective gas along with the furnace to obtain the Mg-based biomaterial.
Preferably, before the metal raw material is smelted, the method further comprises the step of removing oil and an oxide layer from the metal raw material.
Preferably, the smelting in the step B is that the smelting furnace is heated to the smelting temperature, stirred and then kept warm; wherein the smelting temperature is 700-750 ℃; preferably, the temperature rising speed is 0.5 ℃/s; preferably, the stirring time is 10 min; preferably, the time of the heat preservation is 60 min.
Preferably, the carrying container is a graphite crucible; the protective atmosphere is argon; preferably, the pressure value in the smelting furnace during smelting is 0.05 Mpa.
In a third aspect, the invention further provides an application of the Mg-based biomaterial or the method for preparing the Mg-based biomaterial in biomedical materials, preferably, the biomedical materials are artificial implants.
Compared with the prior art, the invention has the following beneficial effects:
1. the elastic modulus of the Mg-based biological material, namely the Mg-based high-entropy alloy, is close to that of human skeleton (0-20 GPa), so that the stress shielding phenomenon can be avoided, and the skeleton growth can be better ensured;
2. the metal type combination used by the Mg-based high-entropy alloy has excellent biocompatibility and no toxic or side effect on a human body;
3. the melting point of the Mg-based high-entropy alloy is lower than that of the existing Mg metal alloy, so that the forging and processing difficulty is reduced, and the Mg-based high-entropy alloy has the potential of being widely applied to the field of biomedical materials;
4. the Mg-based biomaterial has strong corrosion resistance.
Drawings
FIG. 1 is Mg prepared according to the invention in example 1.230Zn30Sn30Bi5Sr5(at%) smelting test pieces with the specification of 40mm multiplied by 20 mm;
FIG. 2 is Mg prepared according to example 1.2 of the present invention30Zn30Sn30Bi5Sr5(at%) the test piece was cut by wire with a specification of 10mm × 10mm × 3 mm;
FIG. 3 is Mg prepared according to example 1.2 of the present invention30Zn30Sn30Bi5Sr5(at%) the test piece is cut linearly, the specification is phi 10mm multiplied by 16 mm;
FIG. 4 is Mg prepared according to example 1.2 of the present invention30Zn30Sn30Bi5Sr5(at%) cut pieces;
FIG. 5 is Mg prepared according to example 1.2 of the present invention30Zn30Sn30Bi5Sr5(at%) pattern SEM measurement of a wire-cut test piece (specification of 10mm × 10mm × 3mm) -electronic image;
FIG. 6 is Mg prepared according to example 1.2 of the present invention30Zn30Sn30Bi5Sr5(at%) SEM measurement of wire-cut test pieces (specification 10mm × 10mm × 3mm) -EDS layered image;
FIG. 7 is Mg prepared according to example 1.2 of the present invention30Zn30Sn30Bi5Sr5(at%) XRD pattern of a test piece (specification of 10 mm. times.10 mm. times.3 mm) for wire cutting.
Detailed Description
The Mg-based biomaterial produced by the present invention will be described in detail below by way of examples with reference to the accompanying drawings. The following examples are merely illustrative of the present invention and are not intended to limit the technical aspects of the present invention. The invention provides a Mg-based biomaterial based on a high-entropy alloy theory, wherein the component expression of the Mg-based biomaterial is MgaZnbSncSrdBieA, b, c, d and e are atomic percentages of the corresponding elements, respectively, wherein: a is more than or equal to 30 and less than or equal to 35, b is more than 0 and less than or equal to 30, c is more than 0 and less than or equal to 30, d is more than 0 and less than or equal to 30, e is more than 0 and less than or equal to 30, and a + b + c + d + e is equal to 100.
Preferably, in the Mg-based biomaterial, a is more than or equal to 30 and less than or equal to 35, b is more than 25 and less than or equal to 30, c is more than 25 and less than or equal to 30, d is more than 5 and less than or equal to 7, and e is more than 5 and less than or equal to 7;
more preferably, the composition expression of the Mg-based biomass is Mg30Zn30Sn30Sr5Bi5。
The melting point of the Mg-based biomaterial is 410-430 ℃; preferably 420 deg.c.
The density of the Mg-based biomaterial is 4.3-4.6g/cm3；
The elastic modulus of the Mg-based biomaterial in the preferable content range of the alloy elements meets the requirement of the elastic modulus of human skeleton, the compressive yield strength value is very close to that of the natural human skeleton, and the preferable elastic modulus of the Mg-based biomaterial is 16-20G/Pa; the compressive yield strength value of the Mg-based biomaterial is 170-210 MPa;
in particular a Mg groupBiomaterial Mg30Zn30Sn30Sr5Bi5Has a density of 4.47g/cm3(ii) a The elastic modulus is 17.98G/Pa; the compressive yield strength value is 192.84 MPa.
The selection consideration factors of the alloy composition elements of the invention are as follows:
the selected alloy elements of the biological material have good biological properties, for example, Mg, Zn and Sn are important elements of a human body, and have basic safety of biomedical application. Mg is an essential element in human bone tissues and is beneficial to the strength and growth of the bone tissues; in the human body, 60% of Zn exists in muscle and 30% in bone tissue, which are components of various enzymes, contribute to the synthesis of proteins and DNA, and promote cell regeneration and tissue metabolism; the main physiological function of Sn is to inhibit the formation of cancer cells to resist tumors, promote the synthesis of protein and nucleic acid and enhance the stability of the body environment. Sr is chemically and physically similar to calcium and is useful in the treatment of osteoporosis because it stimulates bone formation and inhibits bone resorption. Bi is called "green metal" because it is non-toxic to the human body, and is useful as a compound for treating gastrointestinal and dyspepsia, such as bismuth subcarbonate, bismuth nitrite, etc., and as an additive for cosmetics.
In addition, various elements in the biological material of the invention also have the following functions:
bi is added into Mg to be an element with precipitation strengthening effect, and Mg with better thermal stability can be formed after the Bi is added3Bi2And the refining of the as-cast microstructure is realized, and the room-temperature mechanical property of the Mg alloy is improved.
After Sn element is added into pure magnesium, coarse columnar crystal cast ingots can be converted into isometric crystals, crystal grains can be refined, and Mg with the structural characteristic of cubic C1 is generated in the structure2A Sn phase. The maximum solid solubility of Sn is 14.85% at 561.2 deg.C, and when the temperature is reduced to 200 deg.C, the solid solubility of alloy is almost zero, and Mg is precipitated2Sn eutectic phase can form a dispersion strengthening structure.
Like Al, Zn has a solid solution strengthening effect as well as an aging strengthening effect in Mg. Zn can weaken the adverse effect of impurities (such as iron, nickel and the like) in the alloy on the corrosion resistance of the alloy, and can also lower the solidification finish temperature of Mg alloy.
The Sr element can be added to refine Mg alloy grains so as to reduce the tendency of micro-porosity and hot cracking and improve the die casting performance and the mechanical property of the Mg alloy.
Example 1 Mg30Zn30Sn30Bi5Sr5(at%) alloy preparation
1.1 selection of elements for preparing alloys
The pure metals used for smelting are: high purity Mg (particle, purity 99.99 wt.%, specification type is
Figure BDA0003402420000000051
) The high-purity Sn-Sn alloy particle is high in purity (99.999 wt.% in purity and 1-6mm in specification), high-purity Zn (99.999 wt.% in purity and 1-3mm in specification), high-purity Bi (1-3 mm-like spherical particle in purity and 99.999 wt.% in specification) and high-purity Sr (1-3 cm in specification and 99.9 wt.% in purity).
1.2 alloy preparation
The alloy in the research is prepared by high-temperature smelting in a vacuum high-frequency smelting furnace filled with argon protective gas, and the whole smelting process mainly comprises the following steps:
A. in the smelting process of the material, the chemical activity of Mg element is considered, a graphite crucible is used as a main bearing container, the graphite crucible is cleaned before being used, and the graphite crucible is dried after impurities are removed for standby;
B. according to Mg30Zn30Sn30Bi5Sr5The design of the alloy components prepares the use amount of raw materials, and 5 at% -10 at% more than the designed component content of the alloy can be considered when preparing the raw materials for the volatile components so as to ensure that the smelted alloy component is Mg30Zn30Sn30Bi5Sr5. All metal materials used for smelting need operations of removing oil and oxide layers, and are used after the operations are completed;
C. all metal materials are treated and put into a graphite crucible, the process is operated in a sealing box and then put into a vacuum high-frequency smelting furnace, the sealing property of the smelting furnace is required to be ensured before smelting, and oxidation is avoided in the smelting process;
D. starting the mechanical pump until the pressure in the furnace reaches a standard value, then starting the molecular pump, and reducing the pressure in the furnace to the standard value (6 multiplied by 10) in a vacuumizing mode-3Pa), introducing argon protection gas (the final pressure value in the furnace is 0.05MPa), ensuring that the furnace is filled with argon, then heating and smelting, wherein the heating rate is 0.5 ℃/S, observing the smelting condition of the material at any time through a perspective window of the smelting furnace in the heating process, stirring by using a stirring rod at proper time, ensuring that the material can be fully dissolved, the highest heating temperature is 700-750 ℃, starting the stirrer again to fully stir for 5min after the metal material is completely molten, and preserving heat for 60min at 700-750 ℃ after the metal material is uniformly stirred. Complete argon shielding must be ensured throughout the smelting process, and the incorporation of air can easily lead to oxidation of the material.
E. After the smelting process of the metal material is finished, the metal material is naturally cooled and solidified along with the furnace under the action of argon protective gas to generate irregular blocky Mg material30Zn30Sn30Bi5Sr5(at%) A test piece was melted as shown in FIG. 1.
Example 2 analysis of Properties of the Material prepared in example 1
2.1 analysis of measurement results of microstructures
For Mg prepared in example 1.230Zn30Sn30Bi5Sr5(at%) of the wire-cut test pieces having a size of 10mm × 10mm × 3mm (see fig. 2), XRD and SEM measurements were performed, wherein the SEM measurements are shown in FIGS. 5 and 6, and the XRD measurements are shown in FIG. 7.
The combined XRD and SEM analysis shows that the new material Mg30Zn30Sn30Sr5Bi5(at%) is very complex in structure, and has various crystal systems and various types of space groups. The energy spectrum analysis comprises 11 spectrogram analysis points in total, and the analysis result shows that the Mg element serving as a matrix element meets the requirement of nearly uniform distribution in the alloyAnd (6) calculating the demand. The atomic percentages of the elements in each spectrogram point are shown in table 1 below.
TABLE 1 statistical table of atomic percentages of various elements in spectrum point positions
Figure BDA0003402420000000061
Figure BDA0003402420000000071
The atomic percentages of the elements of the three positions of the spectrogram 1, the spectrogram 5, the spectrogram 6 and the spectrogram 9 are very close, and the atomic percentage value of the Bi element is the highest. Analysis showed Mg3Bi2(Crystal system：Hexagonal，Space group：P-3m1，Space group number：164)、MgSnSr(Crystal system：Orthorhombic，Space group：Pnma，Space group number：62)、Bi2SrZn (Crystal system: Tetragonal, Space group: I4/mmm, Space group number: 139) and the like. Wherein the MgSnSr phase presents a rod shape, and when the Sr element content is increased, the forming tendency of the MgSnSr phase is gradually higher than that of Mg2The Sn phase has a forming trend, and the MgSnSr phase has a dispersion strengthening effect, so that the room-temperature mechanical property of the alloy is improved. Mg (magnesium)3Bi2The compound has good thermal stability and creep resistance, and a good precipitation strengthening effect can be obtained by utilizing a heat treatment mode. The positions of spectrogram 2, spectrogram 3, spectrogram 8 and spectrogram 11 are basically consistent, the main elements are Mg and Sn, and the atomic percentages of the Mg and the Sn are close to 2: 1, other elements close to 0, which may be considered as Mg2Sn (Crystal system: Cubic, Space group: Fm-3m, Space group number: 225), Mg (Mg-III)2The Sn compound can effectively improve the amorphous formation of Mg alloy. The 7 position points of the spectrogram are mainly Mg4Sr (Crystal system: Hexagonal, Space group: P63/mmc, Space group number: 194) phase, and Mg4The Sr alloy has fine structure and is dispersed, so that the Mg alloy material can show better modification effect, namely the structure inheritance of the Mg, Sr alloy as the intermediate alloyEffect and low melting temperature and enthalpy. The analysis result of the 10 position of the spectrogram shows that the Sr added into the Mg can form the Mg38Sr9(Crystal system: Hexagonal, Space group: P63/mmc, Space group number: 194) phase, the presence of which causes the grain growth during solidification of the Mg-based alloy to be limited. The content of three elements of Mg, Zn and Sn at the position point of the spectrogram 4 is high, and the content of Sr and Bi elements is extremely low. According to the existing research data, the region can be identified as MgZn phase and Mg2Sn phases are attached and most of MgZn phases should exist in the form of eutectic of alpha-Mg + MgZn phases. In addition, because the elements of the new material have strong oxidizability, the oxygen element exists in the alloy, and oxides of multiple elements also appear in the alloy, such as MgO and ZnSnO3And the like.
2.2 analysis of results of physical mechanical Properties
For Mg prepared in example 1.230Zn30Sn30Bi5Sr5(at%) the melting test piece was subjected to physical mechanical property analysis, wherein the test piece of fig. 3 was used for compression resistance test, the test piece of fig. 4 was used for PSD test, the test piece of fig. 1 was used for density detection, and the test piece of fig. 1 was used for hardness detection.
(1) The new material Mg prepared by the invention30Zn30Sn30Sr5Bi5Melting point (at%): the material prepared in the research example 1.2 shows that a heat absorption and release equilibrium state occurs at 43.32mg sample temperature within 390-430 ℃ through PSD (test piece mass 43.32mg, test temperature range 0-800 ℃) test, and a curve chart shows a horizontal state; in a temperature range of 190-200 ℃, a heat flow peak appears on a curve, and a large amount of Sn element is separated out in a simple substance form by combining simulation analysis, XRD (X-ray diffraction) and SEM (scanning Electron microscope) analysis structures. The heat flow value of the test piece in other temperature intervals is increased along with the temperature rise of the equipment, and no obvious fluctuation change exists. The melting point of the material prepared in the embodiment 1.2 of the invention is judged to be about 420 ℃ by combining the test results of different temperature capacities of the vacuum melting furnace. Is obviously lower than the melting point value of the prior Mg alloy material above 600 ℃, and the low melting point material is more excellent from the viewpoint of processing the casting materialIs advantageous.
(2) The new material Mg prepared by the invention30Zn30Sn30Sr5Bi5(at%) the elastic modulus value was 17.98MPa, and the compressive yield strength value was 192.84 MPa. Data were obtained using a compression experiment using a WDW-100 electronic universal tester.
(3) The new material Mg prepared by the invention30Zn30Sn30Sr5Bi5(at%) has a density of 4.47g/cm3. The data are obtained by gravimetric and buoyancy methods, and the balance is used in accordance with ISO 1183-1.
Mg prepared by the invention30Zn30Sn30Bi5Sr5(at%) the density, modulus of elasticity and compressive yield strength values of the smelted test pieces are plotted against the properties of human bone and common bioimplantation materials in table 2. The data of the performance of the human bone and common organism implant materials in the table 2 are shown in a reference file: yuan Guingyin, Zhang Jia, Ding Wenjiang.research Progress of Mg-Based Alloys as gradable biological materials MATERIALS CHINA,2011, Feb. Vol.30, No.2: 44-50.
TABLE 2
Figure BDA0003402420000000081
Figure BDA0003402420000000091
(4) The new material Mg prepared by the invention30Zn30Sn30Sr5Bi5(at%) hardness test. The maximum hardness value of the material of the invention is 249 HV.
The relevant measuring instrument used in embodiment 2 includes: zeiss-sigma IGMAHD type field emission scanning electron microscope, OXFORD-X-Max 50mm2A model X-ray energy spectrometer, an X' Pert Powder model X-ray diffractometer, a Setaram Setsys Evo synchronous thermal analyzer, a WDW-100 electronic universal tester and an HV-1000 microhardness tester.

Claims (10)

1. The Mg-based biomaterial based on the high-entropy alloy theory is characterized in that the component expression of the Mg-based biomaterial is MgaZnbSncSrdBieA, b, c, d and e are atomic percentages of the corresponding elements, respectively, wherein: a is more than or equal to 30 and less than or equal to 35, b is more than 0 and less than or equal to 30, c is more than 0 and less than or equal to 30, d is more than 0 and less than or equal to 30, e is more than 0 and less than or equal to 30, and a + b + c + d + e is equal to 100.
2. The Mg-based biomaterial according to claim 1, wherein 30. ltoreq. a.ltoreq.35, 25. ltoreq. b.ltoreq.30, 25. ltoreq. c.ltoreq.30, 5. ltoreq. d.ltoreq.7, and 5. ltoreq. e.ltoreq.7.
3. The Mg-based biomaterial of claim 2, wherein the composition of the Mg-based biomaterial is represented by the formula Mg30Zn30Sn30Sr5Bi5。
4. The Mg-based biomaterial of claim 1, wherein the melting point of the Mg-based biomaterial is 410-430 ℃; preferably 420 deg.c.
5. The Mg-based biomaterial of claim 1, wherein the Mg-based biomaterial has a density of 4.3 to 4.6g/cm3(ii) a Preferably, the Mg-based biomaterial has an elastic modulus of 16-20G/Pa; preferably, the compressive yield strength value of the Mg-based biomaterial is 170-210 MPa; further preferably, the Mg-based biomaterial has a density of 4.47g/cm3(ii) a Preferably, the Mg-based biomaterial has an elastic modulus of 17.98G/Pa; preferably, the compressive yield strength value of the Mg-based biomaterial is 192.84 MPa.
6. A method for preparing a Mg-based biomaterial according to any of the claims 1-5, characterized in that it comprises the following steps:
a: preparing a metallic raw material according to the compositional ratio of the Mg-based biomaterial as set forth in any one of claims 1 to 5;
b: b, putting the metal raw material in the step B into a bearing container, and smelting in a smelting furnace under a protective atmosphere;
c: and cooling the Mg-based biomaterial in a protective gas along with the furnace to obtain the Mg-based biomaterial.
7. The production method according to claim 6, further comprising a treatment of degreasing and removing an oxidized layer from the metallic raw material before the metallic raw material is smelted.
8. The preparation method of claim 6, wherein the smelting in the step B is that the smelting furnace is heated to the smelting temperature, stirred and then kept warm; wherein the smelting temperature is 700-750 ℃; preferably, the temperature rising speed is 0.5 ℃/s; preferably, the stirring time is 10 min; preferably, the time of the heat preservation is 60 min.
9. The method of claim 6, wherein the support container is a graphite crucible; the protective atmosphere is argon; preferably, the pressure value in the smelting furnace during smelting is 0.05 Mpa.
10. Use of the Mg-based biomaterial according to any one of claims 1 to 5 or the method of preparation according to any one of claims 6 to 9 for biomedical materials, preferably for artificial implants.
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