CN114127070A - 具有a2a腺苷受体激动剂活性的6-肼基腺苷类化合物 - Google Patents
具有a2a腺苷受体激动剂活性的6-肼基腺苷类化合物 Download PDFInfo
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- CN114127070A CN114127070A CN202080045042.0A CN202080045042A CN114127070A CN 114127070 A CN114127070 A CN 114127070A CN 202080045042 A CN202080045042 A CN 202080045042A CN 114127070 A CN114127070 A CN 114127070A
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- pharmaceutically acceptable
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- phenyl
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- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000004305 thiazinyl group Chemical group S1NC(=CC=C1)* 0.000 description 1
- 125000004496 thiazol-5-yl group Chemical group S1C=NC=C1* 0.000 description 1
- 210000001578 tight junction Anatomy 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
本公开提供了通式(I)所示的具有A2A腺苷受体激动活性的6‑肼基腺苷及其衍生物以及包含它们的药物组合物。该化合物和组合物可作为A2A腺苷受体激动剂用作药剂。
Description
PCT国内申请，说明书已公开。
Claims (20)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910542462 | 2019-06-21 | ||
| CN2019105424629 | 2019-06-21 | ||
| PCT/CN2020/097427 WO2020253870A1 (zh) | 2019-06-21 | 2020-06-22 | 具有a2a腺苷受体激动剂活性的6-肼基腺苷类化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114127070A true CN114127070A (zh) | 2022-03-01 |
Family
ID=74036902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080045042.0A Pending CN114127070A (zh) | 2019-06-21 | 2020-06-22 | 具有a2a腺苷受体激动剂活性的6-肼基腺苷类化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220380402A1 (zh) |
| EP (1) | EP3988550A4 (zh) |
| JP (1) | JP2022538408A (zh) |
| CN (1) | CN114127070A (zh) |
| WO (1) | WO2020253870A1 (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3819613A (en) * | 1970-12-28 | 1974-06-25 | Takeda Chemical Industries Ltd | Adenosine derivatives and the production thereof |
| WO2011123518A1 (en) * | 2010-03-31 | 2011-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders |
| US20120329747A1 (en) * | 2011-06-21 | 2012-12-27 | Jayaram Hiremagular N | Novel hydrazone derivatives having potent antitumor activity toward multi-drug resistant tumor cells |
-
2020
- 2020-06-22 EP EP20827795.4A patent/EP3988550A4/en not_active Withdrawn
- 2020-06-22 CN CN202080045042.0A patent/CN114127070A/zh active Pending
- 2020-06-22 WO PCT/CN2020/097427 patent/WO2020253870A1/zh unknown
- 2020-06-22 JP JP2021576094A patent/JP2022538408A/ja not_active Ceased
- 2020-06-22 US US17/621,003 patent/US20220380402A1/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3819613A (en) * | 1970-12-28 | 1974-06-25 | Takeda Chemical Industries Ltd | Adenosine derivatives and the production thereof |
| CA952102A (en) * | 1970-12-28 | 1974-07-30 | Ryuji Marumoto | Adenosine derivatives and the production thereof |
| WO2011123518A1 (en) * | 2010-03-31 | 2011-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders |
| US20120329747A1 (en) * | 2011-06-21 | 2012-12-27 | Jayaram Hiremagular N | Novel hydrazone derivatives having potent antitumor activity toward multi-drug resistant tumor cells |
Non-Patent Citations (2)
| Title |
|---|
| HUIJUN CHEN ET AL.: "Novel Synthesis of 7 - β - D - Ribofuranosyl- 7H - 1, 2, 4 -triazolo[3, 4-i]purines With Use of NBS", 《SYNTHETIC COMMUNICATIONS》, vol. 36, no. 4, pages 445 - 450 * |
| 徐叔云 编: "《现代实用临床药理学》", vol. 1, 31 August 1996, 华夏出版社, pages: 43 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20220380402A1 (en) | 2022-12-01 |
| EP3988550A4 (en) | 2023-07-05 |
| JP2022538408A (ja) | 2022-09-02 |
| WO2020253870A1 (zh) | 2020-12-24 |
| EP3988550A1 (en) | 2022-04-27 |
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