CN114100194B - Device and method for removing chloroglycerol from glycerophosphorylcholine - Google Patents
Device and method for removing chloroglycerol from glycerophosphorylcholine Download PDFInfo
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- CN114100194B CN114100194B CN202111354249.9A CN202111354249A CN114100194B CN 114100194 B CN114100194 B CN 114100194B CN 202111354249 A CN202111354249 A CN 202111354249A CN 114100194 B CN114100194 B CN 114100194B
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- SUHOQUVVVLNYQR-MRVPVSSYSA-N choline alfoscerate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-N 0.000 title claims abstract description 66
- 239000008777 Glycerylphosphorylcholine Substances 0.000 title claims abstract description 64
- 229960004956 glycerylphosphorylcholine Drugs 0.000 title claims abstract description 64
- URWVQQSVEPXYET-UHFFFAOYSA-N 1-chloropropane-1,2,3-triol Chemical compound OCC(O)C(O)Cl URWVQQSVEPXYET-UHFFFAOYSA-N 0.000 title claims abstract description 49
- 238000000034 method Methods 0.000 title claims abstract description 20
- 230000007246 mechanism Effects 0.000 claims abstract description 44
- 239000004744 fabric Substances 0.000 claims abstract description 12
- 239000011148 porous material Substances 0.000 claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 60
- 230000000670 limiting effect Effects 0.000 claims description 34
- 239000002798 polar solvent Substances 0.000 claims description 13
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 8
- 230000009471 action Effects 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 7
- 239000002245 particle Substances 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 description 6
- 238000000926 separation method Methods 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000002457 bidirectional effect Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000004880 explosion Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000001739 rebound effect Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical group CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000003930 cognitive ability Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000008897 memory decline Effects 0.000 description 1
- 201000000585 muscular atrophy Diseases 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- NQCBIMOYRRMVNA-UHFFFAOYSA-N propane-1,2,3-triol;hydrochloride Chemical compound Cl.OCC(O)CO NQCBIMOYRRMVNA-UHFFFAOYSA-N 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
The invention relates to the technical field of preparation of glycerophosphorylcholine, and discloses a device and a method for removing chloroglycerol from glycerophosphorylcholine, wherein the device for removing the chloroglycerol from the glycerophosphorylcholine comprises a base, a tank body is arranged on the base, a cloth hopper is arranged in the tank body, and a first feeding pipeline is arranged on the cloth hopper; the tank body is internally provided with a centrifugal mechanism, the rotary drum can continuously rotate at a high speed through the operation of the centrifugal mechanism in the device for removing the chloroglycerols in the glycerophosphorylcholine, meanwhile, the pushing disc can also slide back and forth along the inner wall of the rotary drum, under the centrifugal effect of the rotary drum, the chloroglycerols can be thrown out from the pores of the outer wall of the rotary drum and then discharged by the second collecting pipeline, the glycerophosphorylcholine with the particle size larger than the pores is thrown into cake-shaped residues on the inner wall of the rotary drum, and the glycerophosphorylcholine is pushed out of the rotary drum by the reciprocating pushing disc and then discharged by the first collecting pipeline, so that the removal of the chloroglycerols from the glycerophosphorylcholine is completed.
Description
Technical Field
The invention relates to the technical field of preparation of glycerophosphorylcholine, in particular to a device and a method for removing chloroglycerol from glycerophosphorylcholine.
Background
Glycerol phosphatidylcholine, also known as lecithin, is a white or pale yellow powder for digestive system/liver disease adjuvant therapy. In addition, glycerophosphatidylcholine is also an anti-aging nutrient for the brain. The main chemical substance that builds and stores memory is acetylcholine, a common cause of memory decline, and the nutrient substance that such memory molecules are derived from in foods is glycerophosphorylcholine. Clinical studies show that the glycerophosphorylcholine not only can improve the memory and the cognitive ability of people, but also has obvious curative effects on cerebral circulation decline and Alzheimer's disease, and can also resist muscular atrophy and protect blood vessels. In general, there is very little glycerophosphorylcholine in foods, so that additional administration of the glycerophosphorylcholine preparation is required if it is intended to achieve therapeutic effects by supplementing it.
In the prior art process of preparing glycerophosphorylcholine, there is a lack of a process for removing a small amount of residual chloroglycerol. The glycerol chloride as an impurity not only affects the quality and the efficacy of the glycerophosphorylcholine, but also has a certain degree of toxicity, and excessive intake is harmful to human health.
Disclosure of Invention
The invention provides a device and a method for removing the chlorglycerol from the glycerophosphorylcholine, which have the beneficial effect of completely removing the chlorglycerol from the glycerophosphorylcholine, and solve the problems that the prior art mentioned in the background art lacks a process for removing a small amount of residual chlorglycerol in the process of preparing the glycerophosphorylcholine, can influence the quality and the efficacy of the glycerophosphorylcholine, can remain a certain degree of toxicity and is harmful to human health after excessive intake.
The invention provides the following technical scheme: the device for removing the chloroglycerol from the glycerophosphorylcholine comprises a base, wherein a tank body is arranged on the base, a cloth hopper is arranged in the tank body, and a first feeding pipeline is arranged on the cloth hopper;
the centrifugal mechanism comprises a sliding groove arranged on the tank body, a screw is arranged in the sliding groove in a sliding manner, a rotary table is rotatably arranged on the screw, a first limit groove is arranged in the tank body, the rotary table is rotatably arranged in the first limit groove, a rotary drum is arranged in the tank body, a pushing disc is arranged on the screw, and the pushing disc is slidably arranged in the rotary drum;
the base is also provided with a reciprocating mechanism and a rotation limiting mechanism, the reciprocating mechanism is connected with the screw rod to drive the screw rod to reciprocate, and the rotary table is connected with the rotary drum through the rotation limiting mechanism.
As an alternative to the device for removing chloroglycerol from glycerophosphorylcholine according to the present invention, wherein: the tank body is internally provided with a second limit groove, the rotary drum is provided with a first connecting plate, the first connecting plate is rotationally arranged in the second limit groove, the tank body is internally provided with a second connecting plate, and the rotary drum is rotationally arranged on the second connecting plate.
As an alternative to the device for removing chloroglycerol from glycerophosphorylcholine according to the present invention, wherein: the reciprocating mechanism comprises a motor arranged on the base, a half gear is arranged on the motor, an annular rack is arranged on the screw rod, and the annular rack is meshed with the half gear.
As an alternative to the device for removing chloroglycerol from glycerophosphorylcholine according to the present invention, wherein: two third limiting grooves are symmetrically formed in the base, two limiting blocks are symmetrically arranged on the annular rack, and the two limiting blocks are respectively arranged in the two third limiting grooves in a sliding mode.
As an alternative to the device for removing chloroglycerol from glycerophosphorylcholine according to the present invention, wherein: the rotating limiting mechanism comprises a pawl which is arranged on the rotating disc in a rotating mode, a connecting ring is arranged on the rotating disc, a spring is arranged on the connecting ring, the connecting ring is elastically connected with the pawl through the spring, an inner ratchet wheel is arranged on the first connecting plate, and the inner ratchet wheel is meshed with the pawl.
As an alternative to the device for removing chloroglycerol from glycerophosphorylcholine according to the present invention, wherein: the pawl and the spring are all provided with a plurality of, and a plurality of the pawl and a plurality of the spring are respectively and evenly arranged on the turntable.
As an alternative to the device for removing chloroglycerol from glycerophosphorylcholine according to the present invention, wherein: the tank body is further provided with a collecting mechanism, the collecting mechanism comprises a first collecting pipeline arranged on the tank body, the first collecting pipeline is arranged on the second connecting plate, and the tank body is further provided with a second collecting pipeline.
As an alternative to the device for removing chloroglycerol from glycerophosphorylcholine according to the present invention, wherein: the first feeding pipeline is provided with a second feeding pipeline, and the second feeding pipeline is communicated with the first feeding pipeline.
As an alternative to the device for removing chloroglycerol from glycerophosphorylcholine according to the present invention, wherein: the screw is provided with a conical block, and the conical block is arranged in the cloth hopper.
The invention also provides a using method of the device for removing the chlorglycerol from the glycerophosphorylcholine, which comprises the following steps: the method comprises the following steps:
s1, controlling a motor to operate so as to drive a half gear to rotate, further driving an annular rack and a screw rod to do reciprocating linear motion, enabling the screw rod to slide back and forth along a sliding groove, further driving a rotary table to rotate reciprocally, enabling the rotary table to output unidirectional rotation of a first connecting plate under the rotation limiting effect of an inner ratchet wheel and a plurality of pawls, and enabling a rotary drum to rotate continuously and unidirectionally;
s2, after the motor starts to operate, glycerol phosphatidylcholine without glycerol removal is injected into the rotary drum through a first feeding pipeline, then polar solvent is injected into the rotary drum through a second feeding pipeline to extract the glycerol, and the polar solvent and the glycerol which are in liquid state under the centrifugal effect of the rotary drum flow out from the pores of the outer wall of the rotary drum to a second collecting pipeline for collection;
s3, when the rotary drum continuously rotates, the pushing disc can slide back and forth along the inner wall of the rotary drum under the drive of the screw rod, after the chlorglycerol is filtered by the rotary drum, the glycerophosphorylcholine is stuck on the inner wall of the rotary drum in a cake shape, and at the moment, the pushing disc can continuously push the glycerophosphorylcholine out of the rotary drum to enter the first collecting pipeline for collecting.
The invention has the following beneficial effects:
1. according to the device and the method for removing the glycerophosphoryl from the glycerophosphoryl choline, the reciprocating motion mechanism drives the centrifugal mechanism to operate, so that the rotary drum continuously rotates at high speed, the pushing disc slides back and forth along the inner wall of the rotary drum, the glycerophosphoryl choline is injected into the rotary drum through the first feeding pipeline, the glycerophosphoryl choline is thrown out of the rotary drum from the pores on the outer wall of the rotary drum under the centrifugal action of the rotary drum and is discharged from the second collecting pipeline, the glycerophosphoryl choline with the particle size larger than that of the pores is thrown into cake-shaped residues on the inner wall of the rotary drum, and the glycerophosphoryl choline is pushed out of the rotary drum from the right side by the reciprocating pushing disc and is discharged from the first collecting pipeline, so that separation of the glycerophosphoryl choline and the glycerophosphoryl choline is completed.
2. According to the device and the method for removing the chloroglycerol from the glycerophosphatidylcholine, the bidirectional rotating turntable carries out unidirectional rotation output on the first connecting plate, the rotation limiting mechanism is arranged, when the turntable rotates positively, the rotating direction of the pawl is opposite to the direction of the teeth of the inner ratchet wheel, the pawl can be clamped with the inner ratchet wheel so as to drive the inner ratchet wheel and the first connecting plate to rotate, when the turntable rotates reversely, the rotating direction of the pawl is in compliance with the direction of the teeth of the inner ratchet wheel, the pawl cannot be clamped with the inner ratchet wheel, and continuously swings back and forth in a small amplitude under the compression rebound effect of the spring, and at the moment, the inner ratchet wheel, the first connecting plate and the rotary drum continue to rotate under the inertia effect, so that the rotary drum can keep the same direction and continuously rotate.
3. The device and the method for removing the chloroglycerol from the glycerophosphorylcholine are used for assisting centrifugal separation, a second feeding pipeline is arranged on a first feeding pipeline, a polar solvent can be injected into the first feeding pipeline through the second feeding pipeline, the polar solvent is converged with the glycerophosphorylcholine containing the chloroglycerol in the first feeding pipeline, the polar solvent plays a role in extraction, the chloroglycerol is dissolved in the solvent, the glycerophosphorylcholine is insoluble, and the polar solvent and the chloroglycerol are discharged from a second collecting pipeline and the glycerophosphorylcholine is discharged from a first collecting pipeline through the centrifugal action of a centrifugal mechanism.
Drawings
Fig. 1 is a schematic diagram of the overall structure of the present invention.
Fig. 2 is a schematic diagram of an explosive structure according to the present invention.
Fig. 3 is a schematic view of a first partial explosion structure according to the present invention.
Fig. 4 is a schematic view of a second partial explosion structure according to the present invention.
Fig. 5 is a schematic view of the internal structure of the present invention.
Fig. 6 is a partial enlarged view at a in fig. 5.
In the figure: 1. a base; 2. a tank body; 3. a cloth hopper; 301. a first feed conduit; 302. a second feed conduit; 4. a centrifugal mechanism; 401. a chute; 402. a screw; 403. a turntable; 404. a first limit groove; 405. a rotating drum; 406. a pushing tray; 407. a first connection plate; 408. a second connecting plate; 409. the second limit groove; 410. a conical block; 5. a reciprocating mechanism; 501. a motor; 502. an annular rack; 503. a half gear; 504. a limiting block; 505. a third limit groove; 6. a rotation limiting mechanism; 601. a pawl; 602. a connecting ring; 603. a spring; 604. an inner ratchet; 7. a collection mechanism; 701. a first collection conduit; 702. and a second collection conduit.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
Referring to fig. 1-6, a device for removing chloroglycerol from glycerophosphorylcholine comprises a base 1, wherein a tank 2 is arranged on the base 1, a cloth hopper 3 is arranged in the tank 2, and a first feeding pipeline 301 is arranged on the cloth hopper 3;
a centrifugal mechanism 4 is arranged in the tank body 2, the centrifugal mechanism 4 comprises a chute 401 arranged on the tank body 2, a screw rod 402 is arranged in the chute 401 in a sliding way, a rotary table 403 is arranged on the screw rod 402 in a rotating way, a first limit groove 404 is arranged in the tank body 2, the rotary table 403 is arranged in the first limit groove 404 in a rotating way, a rotary drum 405 is arranged in the tank body 2, a pushing disc 406 is arranged on the screw rod 402, and the pushing disc 406 is arranged in the rotary drum 405 in a sliding way;
the base 1 is also provided with a reciprocating mechanism 5 and a rotation limiting mechanism 6, the reciprocating mechanism 5 is connected with the screw 402 to drive the screw to reciprocate, and the turntable 403 is connected with the rotary drum 405 through the rotation limiting mechanism 6.
In this embodiment: in order to remove the chloroglycerol which is difficult to remove, the glycerophosphorylcholine and the chloroglycerol are separated by adopting a centrifugal principle, and a turntable 403 is in threaded connection with a screw 402, and the screw 402 is driven to slide left and right in a reciprocating manner along a chute 401 by a reciprocating mechanism 5;
under the limiting action of the first limiting groove 404 on the rotary table 403, the screw 402 drives the rotary table 403 to reciprocally rotate in situ, and the rotary table 403 transmits unidirectional rotation output to the rotary drum 405 through the rotation limiting mechanism 6, so that the rotary drum 405 continuously rotates in a unidirectional manner;
meanwhile, the pushing disc 406 also slides back and forth along the inner wall of the rotary drum 405 under the driving of the screw 402, and the two are tightly attached, the first feeding pipeline 301 is used for injecting glycerol phosphatidylcholine without chlorglycerol removal into the cloth hopper 3, the cloth hopper 3 uniformly distributes the glycerol phosphatidylcholine in the rotary drum 405, the glycerol phosphatidylcholine is thrown out of the rotary drum 405 from the gap of the outer wall of the rotary drum 405 under the rotation centrifugal effect of the rotary drum 405, the glycerol phosphatidylcholine with the particle size larger than the pore is thrown into cake-shaped residue on the inner wall of the rotary drum 405, and then the glycerol phosphatidylcholine is pushed out of the rotary drum 405 from the right side under the reciprocating pushing of the pushing disc 406, so that the separation of the glycerol phosphatidylcholine and the glycerol phosphatidylcholine is completed.
Example 2
Referring to fig. 1-6, a second limit groove 409 is formed in the tank 2, a first connection plate 407 is disposed on the drum 405, the first connection plate 407 is rotatably disposed in the second limit groove 409, a second connection plate 408 is disposed in the tank 2, and the drum 405 is rotatably disposed on the second connection plate 408.
In this embodiment: in order to limit the rotation of the rotary drum 405, a first connecting plate 407 is arranged at the left end of the rotary drum 405, the first connecting plate 407 rotates in the second limiting groove 409 to limit and support the rotary drum 405, so that the rotary drum 405 rotates more stably, and the rotary drum 405 itself rotates on the left side of the second connecting plate 408 to further strengthen the limiting effect of the rotary drum 405, so that the rotary drum 405 can rotate in the tank 2 stably at a high speed.
Example 3
Referring to fig. 1-6, the reciprocating mechanism 5 includes a motor 501 disposed on the base 1, a half gear 503 is disposed on the motor 501, an annular rack 502 is disposed on the screw 402, and the annular rack 502 is meshed with the half gear 503.
In this embodiment: in order to realize the reciprocating motion of the screw 402, a reciprocating motion mechanism 5 is arranged, the left part of the annular rack 502 is elliptical, straight teeth are distributed on the front side and the rear side of the elliptical and meshed with the half gear 503, the right side of the annular rack 502 is rectangular and connected with the screw 402, the half gear 503 can be driven to rotate through the operation of the motor 501, at the moment, the half gear 503 is meshed with the teeth on the rear side of the annular rack 502, the half gear 503 can drive the annular rack 502 to move rightwards under the limiting effect of the sliding of the screw 402 in the sliding groove 401, and when the half gear 503 rotates to be separated from the teeth on the rear side of the annular rack 502, the half gear 503 starts to be meshed with the teeth on the front side of the annular rack 502, and then the annular rack 502 can be driven to move leftwards, so that the screw 402 can be washed to reciprocate leftwards and rightwards.
Example 4
Referring to fig. 1-6, two third limiting grooves 505 are symmetrically arranged on the base 1, two limiting blocks 504 are symmetrically arranged on the annular rack 502, and the two limiting blocks 504 are respectively slidably arranged in the two third limiting grooves 505.
In this embodiment: for further exerting spacing to annular rack 502, offered two third spacing groove 505 of fore-and-aft symmetry on base 1, be provided with two stopper 504 of fore-and-aft symmetry on annular rack 502 to stopper 504 and third spacing groove 505 are the T font, slide along two third spacing groove 505 in the fore-and-aft respectively through two stopper 504, can play support and spacing effect to annular rack 502, make its left and right sides remove more steadily.
Example 5
Referring to fig. 1-6, the rotation limiting mechanism 6 includes a pawl 601 rotatably disposed on a turntable 403, a connection ring 602 is disposed on the turntable 403, a spring 603 is disposed on the connection ring 602, the connection ring 602 is elastically connected with the pawl 601 through the spring 603, an inner ratchet 604 is disposed on the first connection plate 407, and the inner ratchet 604 is meshed with the pawl 601.
In this embodiment: in order to make the bidirectional rotating turntable 403 perform unidirectional rotation output on the first connecting plate 407, a rotation limiting mechanism 6 is provided, when the turntable 403 rotates, the pawl 601 also rotates along the internal teeth of the inner ratchet wheel 604, when the rotation direction of the pawl 601 is opposite to the direction of the teeth of the inner ratchet wheel 604, the pawl 601 is clamped with the inner ratchet wheel 604, and then drives the inner ratchet wheel 604 and the first connecting plate 407 to rotate, when the rotation direction of the pawl 601 is in line with the direction of the teeth of the inner ratchet wheel 604, the pawl 601 is not clamped with the inner ratchet wheel 604, and continuously swings back and forth in a small amplitude under the compression rebound effect of the spring 603, and at the moment, the inner ratchet wheel 604, the first connecting plate 407 and the rotary drum 405 continue to rotate under the inertia effect, so that the rotary drum 405 keeps continuously rotating in a single direction.
Example 6
Referring to fig. 1-6, a plurality of pawls 601 and springs 603 are provided, and the plurality of pawls 601 and springs 603 are uniformly disposed on the turntable 403, respectively.
In this embodiment: in order to make the transmission between the turntable 403 and the first connecting plate 407 more stable, the pawls 601 and the springs 603 are arranged in three and uniformly arranged on the turntable 403 circumferentially, so that the internal ratchet 604 is stressed more uniformly and the transmission is more stable.
Example 7
Referring to fig. 1-6, the tank 2 is further provided with a collecting mechanism 7, the collecting mechanism 7 includes a first collecting pipe 701 disposed on the tank 2, the first collecting pipe 701 is disposed on a second connecting plate 408, and a second collecting pipe 702 is further disposed on the tank 2.
In this embodiment: in order to collect the separated chloroglycerol and the glycerophosphorylcholine, a collecting mechanism 7 is provided, the chloroglycerol thrown out by the rotary drum 405 is distributed in a closed space formed by the first connecting plate 407, the tank 2 and the second connecting plate 408, the chloroglycerol moves downwards on the smooth inner wall of the tank 2 to be gathered and finally flows out of the second collecting pipeline 702, and the glycerophosphorylcholine is pushed into an opening below the second connecting plate 408 by the pushing tray 406 and then is discharged from the first collecting pipeline 701.
Example 8
Referring to fig. 1-6, a second feed pipe 302 is disposed on the first feed pipe 301, and the second feed pipe 302 is in communication with the first feed pipe 301.
In this embodiment: to assist the centrifugal separation, a second feed pipe 302 is provided on the first feed pipe 301, and a polar solvent can be injected into the first feed pipe 301 from the second feed pipe 302, and the polar solvent merges with the glycerophosphorylcholine containing the chloroglycerols in the first feed pipe 301, the polar solvent plays an extraction role, the chloroglycerols are dissolved in the solvent, and the glycerophosphorylcholine is insoluble.
Example 9
Referring to fig. 1 to 6, a conical block 410 is disposed on the screw 402, and the conical block 410 is disposed in the cloth hopper 3.
In this embodiment: to assist the material distribution of the material distribution hopper 3, a conical block 410 is further disposed at the right end of the screw 402, and when the material is injected into the material distribution hopper 3 through the first feeding pipe 301, the material will impinge on the conical block 410 and be uniformly dispersed into the drum 405.
The embodiment also provides a using method of the device for removing the chlorglycerol from the glycerophosphorylcholine, which comprises the following steps:
s1, a motor 501 is controlled to operate so as to drive a half gear 503 to rotate, and then drive an annular rack 502 and a screw 402 to do reciprocating linear motion, so that the screw 402 slides back and forth along a chute 401, and then drives a rotary table 403 to do reciprocating rotation, and under the rotation limiting effect of an inner ratchet 604 and a plurality of pawls 601, the rotary table 403 can perform unidirectional rotation output on a first connecting plate 407, so that a rotary drum 405 continuously rotates in a unidirectional manner;
s2, after the motor 501 starts to operate, glycerol phosphatidylcholine without glycerol removal is injected into the rotary drum 405 through the first feeding pipeline 301, then polar solvent is injected into the rotary drum 405 through the second feeding pipeline 302 to extract the glycerol, and the polar solvent and the glycerol which are in liquid state under the centrifugal action of the rotary drum 405 flow out from the pores of the outer wall of the rotary drum 405 to the second collecting pipeline 702 for collection;
s3, while the rotary drum 405 continuously rotates, the pushing disc 406 slides reciprocally along the inner wall of the rotary drum 405 under the driving of the screw 402, after the chlorglycerol is filtered by the rotary drum 405, the glycerophosphorylcholine is stuck to the inner wall of the rotary drum 405 in a cake shape, and at this time, the pushing disc 406 continuously pushes the glycerophosphorylcholine out of the rotary drum 405 and enters the first collecting pipeline 701 for collection.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
The foregoing is merely a preferred embodiment of the present invention, and it should be noted that it will be apparent to those skilled in the art that several modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the scope of the invention.
Claims (9)
1. A device for removing chloroglycerol from glycerophosphorylcholine, comprising a base (1), characterized in that: the novel material distribution device is characterized in that a tank body (2) is arranged on the base (1), a material distribution hopper (3) is arranged in the tank body (2), and a first feeding pipeline (301) is arranged on the material distribution hopper (3);
a centrifugal mechanism (4) is arranged in the tank body (2), the centrifugal mechanism (4) comprises a chute (401) arranged on the tank body (2), a screw (402) is arranged in the chute (401) in a sliding manner, a rotary table (403) is rotatably arranged on the screw (402), a first limit groove (404) is arranged in the tank body (2), the rotary table (403) is rotatably arranged in the first limit groove (404), a rotary drum (405) is arranged in the tank body (2), a pushing disc (406) is arranged on the screw (402), and the pushing disc (406) is slidably arranged in the rotary drum (405);
a first connecting plate (407) is arranged on the rotary drum (405);
the rotation limiting mechanism (6) comprises a pawl (601) which is rotatably arranged on the rotary table (403), a connecting ring (602) is arranged on the rotary table (403), a spring (603) is arranged on the connecting ring (602), the connecting ring (602) is elastically connected with the pawl (601) through the spring (603), an inner ratchet wheel (604) is arranged on the first connecting plate (407), and the inner ratchet wheel (604) is meshed with the pawl (601);
the base (1) is also provided with a reciprocating mechanism (5) and a rotation limiting mechanism (6), the reciprocating mechanism (5) is connected with the screw (402) to drive the screw to reciprocate, and the rotary table (403) is connected with the rotary drum (405) through the rotation limiting mechanism (6).
2. The apparatus for removing chloroglycerol from glycerophosphorylcholine according to claim 1, wherein: the novel tank is characterized in that a second limit groove (409) is formed in the tank body (2), the first connecting plate (407) is rotatably arranged in the second limit groove (409), a second connecting plate (408) is arranged in the tank body (2), and the rotary drum (405) is rotatably arranged on the second connecting plate (408).
3. The apparatus for removing chloroglycerol from glycerophosphorylcholine according to claim 2, wherein: the reciprocating mechanism (5) comprises a motor (501) arranged on the base (1), a half gear (503) is arranged on the motor (501), an annular rack (502) is arranged on the screw (402), and the annular rack (502) is meshed with the half gear (503).
4. A device for removing chloroglycerol from glycerophosphorylcholine according to claim 3, wherein: two third limiting grooves (505) are symmetrically formed in the base (1), two limiting blocks (504) are symmetrically arranged on the annular rack (502), and the two limiting blocks (504) are respectively arranged in the two third limiting grooves (505) in a sliding mode.
5. The apparatus for removing chloroglycerol from glycerophosphorylcholine according to claim 4, wherein: the pawl (601) and the spring (603) are both provided with a plurality of pawls (601) and a plurality of springs (603) are respectively and uniformly arranged on the turntable (403).
6. The apparatus for removing chloroglycerol from glycerophosphorylcholine according to claim 5, wherein: the novel tank is characterized in that a collecting mechanism (7) is further arranged on the tank body (2), the collecting mechanism (7) comprises a first collecting pipeline (701) arranged on the tank body (2), the first collecting pipeline (701) is arranged on the second connecting plate (408), and a second collecting pipeline (702) is further arranged on the tank body (2).
7. The apparatus for removing chloroglycerol from glycerophosphorylcholine according to claim 6, wherein: a second feeding pipeline (302) is arranged on the first feeding pipeline (301), and the second feeding pipeline (302) is communicated with the first feeding pipeline (301).
8. The apparatus for removing chloroglycerol from glycerophosphorylcholine according to claim 7, wherein: the screw (402) is provided with a conical block (410), and the conical block (410) is arranged in the cloth hopper (3).
9. The device for removing chloroglycerol from glycerophosphorylcholine according to any of claims 1-8, which is used in the following method:
s1, controlling a motor (501) to operate so as to drive a half gear (503) to rotate, further driving an annular rack (502) and a screw (402) to do reciprocating linear motion, enabling the screw (402) to slide back and forth along a sliding groove (401), further driving a rotary table (403) to rotate reciprocally, and enabling the rotary table (403) to output unidirectional rotation of a first connecting plate (407) under the rotation limiting effect of an inner ratchet wheel (604) and a plurality of pawls (601), and enabling a rotary drum (405) to rotate continuously and unidirectionally;
s2, after the motor (501) starts to operate, glycerol phosphatidylcholine without removing the glycerol is injected into the rotary drum (405) through a first feeding pipeline (301), then the polar solvent is injected into the rotary drum (405) through a second feeding pipeline (302) to extract the glycerol, and the polar solvent and the glycerol which are in liquid state under the centrifugal action of the rotary drum (405) flow out from the pores of the outer wall of the rotary drum (405) to a second collecting pipeline (702) for collection;
s3, when the rotary drum (405) continuously rotates, the pushing disc (406) can slide back and forth along the inner wall of the rotary drum (405) under the drive of the screw (402), after the chlorglycerol is filtered by the rotary drum (405), the glycerophosphorylcholine is stuck on the inner wall of the rotary drum (405) in a cake shape, and at the moment, the pushing disc (406) can continuously push the glycerophosphorylcholine out of the rotary drum (405) to enter the first collecting pipeline (701) for collecting.
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| JP6716803B1 (en) * | 2019-06-20 | 2020-07-01 | 广州蕭浦科技有限公司 | Robot arm for classification of PET bottle production line |
| JP2021070802A (en) * | 2019-11-01 | 2021-05-06 | 朱暁鳳 | Facility for flattening and drying leather for briefcase |
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| JPS6081B2 (en) * | 1982-07-26 | 1985-01-05 | サヌキ工業株式会社 | automatic extraction device |
| US7008528B2 (en) * | 2001-03-22 | 2006-03-07 | Mitchell Allen R | Process and system for continuously extracting oil from solid or liquid oil bearing material |
| AT411429B (en) * | 2002-08-26 | 2004-01-26 | Natex Prozesstech Gmbh | Extraction of impurities from thinly-coated fluid film involves treating its surface with liquid carbon dioxide whilst continuously replenishing film thickness |
| CN110128467A (en) * | 2019-05-07 | 2019-08-16 | 天津康巢生物医药股份有限公司 | A kind of process of purification of glycerol phosphatidyl choline crude product and its obtained glycerolphosphocholine |
| CN113337395A (en) * | 2021-05-12 | 2021-09-03 | 王明辉 | Intelligent centrifugal rapid extraction device and extraction method for stem cells |
| CN113275449B (en) * | 2021-07-19 | 2021-10-01 | 烟台智汇港科技创新有限公司 | Integrated linkage metal stamping mechanical equipment based on hole forming of fruit diameter measurer |
| CN113522543B (en) * | 2021-07-19 | 2023-03-28 | 浙江大茗堂生物科技有限公司 | Centrifugal extraction device for aromatic substances in tea |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN207324142U (en) * | 2017-08-18 | 2018-05-08 | 天津市圣信唯科技有限公司 | A kind of Vacuum Manifold for Solid Phase Extraction of novel anticorrosion |
| JP6716803B1 (en) * | 2019-06-20 | 2020-07-01 | 广州蕭浦科技有限公司 | Robot arm for classification of PET bottle production line |
| JP2021070802A (en) * | 2019-11-01 | 2021-05-06 | 朱暁鳳 | Facility for flattening and drying leather for briefcase |
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