CN114099777A - Multi-layer active coating for orthopedic implant and preparation method thereof - Google Patents
Multi-layer active coating for orthopedic implant and preparation method thereof Download PDFInfo
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- CN114099777A CN114099777A CN202111408288.2A CN202111408288A CN114099777A CN 114099777 A CN114099777 A CN 114099777A CN 202111408288 A CN202111408288 A CN 202111408288A CN 114099777 A CN114099777 A CN 114099777A
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- orthopedic implant
- coating
- bionic
- tantalum metal
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- 239000007943 implant Substances 0.000 title claims abstract description 105
- 230000000399 orthopedic effect Effects 0.000 title claims abstract description 83
- 238000000576 coating method Methods 0.000 title claims abstract description 68
- 239000011248 coating agent Substances 0.000 title claims abstract description 66
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000002513 implantation Methods 0.000 title description 6
- 239000010410 layer Substances 0.000 claims abstract description 68
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical group [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims abstract description 41
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 32
- 239000011664 nicotinic acid Substances 0.000 claims abstract description 22
- 239000002346 layers by function Substances 0.000 claims abstract description 18
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 13
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 12
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 12
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 11
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- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 11
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- 239000000463 material Substances 0.000 claims abstract description 10
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- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 22
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- 238000005507 spraying Methods 0.000 claims description 21
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- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 7
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- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical class [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 claims description 4
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- 229960003165 vancomycin Drugs 0.000 claims description 3
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims description 3
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims description 3
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- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical group Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 description 1
- 210000000588 acetabulum Anatomy 0.000 description 1
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- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
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- 229910052586 apatite Inorganic materials 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 239000004053 dental implant Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
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- 238000001035 drying Methods 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
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- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
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Images
Classifications
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- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
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- C23C14/06—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
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- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
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Abstract
The invention relates to the technical field of biomedical materials, in particular to an orthopedic implant multilayer active coating and a preparation method thereof. The coating comprises a basic strengthening layer, a bionic layer and an active functional layer; the basic strengthening layer is a tantalum metal layer; the bionic layer is a calcium phosphate or hydroxyapatite coating; the active functional layer is a coating comprising one or more of bone morphogenetic proteins, bone growth factors or antibiotics. The inside tantalum metal layer forms compact coating on orthopedic implant substrate surface as strengthening layer and the inside strengthening layer and the bionical layer in bionical layer, and intensity is high, is difficult for the fracture to drop, and bionical layer surface adheres to has biological function molecule and medicine, can promote the growth of bone tissue, and the inflammatory reaction is avoided to antibiotic medicine.
Description
Technical Field
The invention relates to the technical field of biomedical materials, in particular to an orthopedic implant multilayer active coating and a preparation method thereof.
Background
Currently, most of common orthopedic implantation instruments such as acetabular cups, intervertebral fusion devices, joint prostheses, bone plates, dental implants and the like need to bear certain mechanical support performance as bone implantation instruments, and therefore the orthopedic implantation instruments have appropriate load capacity, corrosion resistance and wear resistance. Once the bone implant prosthesis collapses, wears and corrodes on the surface in the later period, the patient needs secondary operation treatment, such as revision operations of hip joint and knee joint, revision operations of intervertebral fusion cage and the like, the operation pain is brought to the patient, and the economic pressure of treatment of the patient is increased.
The existing acetabulum cup is usually prepared from materials such as titanium alloy, tantalum metal, cobalt-chromium alloy, ultra-high molecular weight polyethylene and the like, an intervertebral fusion device is mostly prepared from materials such as titanium alloy, PEEK, bovine bone and the like, bovine bone prosthesis has the problems of rejection, infection, poor activity and the like, although the titanium alloy intervertebral fusion device can maintain intervertebral stability, the titanium alloy intervertebral fusion device is difficult to realize bone conduction and bone growth induction and realizes connection growth with host bone, so that the fusion effect is poor, although the elastic modulus of the PEEK material is close to human bone, the surface hydrophilic groups are few, a space cannot be provided for cell adhesion, the PEEK material has biological inertia, and the bone integration capability is still insufficient. The existing partial orthopedic implants adopt hydroxyapatite coatings to provide titanium alloy bone fusion performance, but titanium alloy particles generated by long-term bearing abrasion of the orthopedic implants still exist, and the abrasion particles around the prosthesis can cause inflammation, which is one of the main reasons of failure of prosthesis replacement operation and revision of the operation. At present, a hydroxyapatite coating is prepared on the surface of an orthopedic implant, but plasma spraying requires high temperature conditions and easily causes the blockage of a porous structure, so that the implant cannot exert the performance of guiding bone ingrowth by the porous structure.
Disclosure of Invention
The invention aims to solve the technical problems that the existing metal orthopedic implant instrument is easy to wear, has poor particle and corrosion resistance, has poor porous structure aging caused by difficult modification of porous implant apatite, and has poor fusion effect between the implant and host bone caused by insufficient biocompatibility.
In view of the above, the embodiment of the present invention provides a multi-layer active coating for an orthopedic implant, which is applied to a metal bone implant, and the coating comprises a basal strengthening layer, a bionic layer and an active functional layer;
the basic strengthening layer is a tantalum metal layer;
the bionic layer is a calcium phosphate or hydroxyapatite coating;
the active functional layer is a coating comprising one or more of bone morphogenetic proteins, bone growth factors or antibiotics.
Further, the metal bone implant is any one of an intervertebral fusion device with a porous structure, an acetabular cup, an artificial vertebral body and a filling block, and the material of the metal bone implant is one of TC4 titanium alloy, pure titanium and cobalt-chromium alloy.
Further, the thickness of the tantalum metal layer is 10-40 μm.
Further, the antibiotic is one or more of gentamicin, vancomycin and clindamycin.
Based on the same inventive concept, the embodiment of the invention also provides a preparation method of the multi-layer active coating of the orthopedic implant, which comprises the following steps:
performing sand blasting treatment and cleaning on the orthopedic implant to obtain a pretreated orthopedic implant;
preparing a tantalum metal layer by adopting a magnetron sputtering spraying method to the pretreated orthopedic implant to obtain a tantalum metal layer orthopedic implant;
activating the tantalum metal layer orthopedic implant by alkali, and introducing a bionic layer by a sol-gel method, plasma spraying, electrochemical deposition or a bionic deposition method to obtain a bionic-tantalum metal orthopedic implant;
and introducing the bionic-tantalum metal orthopedic implant into an active functional layer by adopting a spraying method or a dipping method to obtain the multi-layer active coating of the orthopedic implant.
Further, the magnetron sputtering spraying method specifically comprises the following steps:
the protective gas of the cavity of the magnetron sputtering spraying instrument is high-purity argon with the purity of 99.99 percent, the negative voltage of the cathode is between 260 and 330V, and when the sputtering cavity is vacuumized to be less than 2 x 10 < -3 > Pa, the argon is filled to 2 to 5 Pa; the target base spacing was 20 mm.
Further, the alkali adopted by the tantalum metal layer orthopedic implant through the alkali activation process is sodium hydroxide or alkaline dopamine.
Further, the step of introducing the bionic-tantalum metal orthopedic implant into an active functional layer by adopting a spraying method or a dipping method to obtain a multi-layer active coating of the orthopedic implant specifically comprises the following steps:
preparing an active functional layer solution: adding bone morphogenetic protein or bone growth factor into distilled water to prepare 5-10mg/mL biomacromolecule solution or suspension; adding antibiotics into distilled water to prepare 1-3mg/mL antibiotic water solution;
and mixing the biomacromolecule solution or suspension with an antibiotic aqueous solution, and introducing an active functional layer into the bionic-tantalum metal orthopedic implant by adopting a spraying method or a dipping method.
Has the advantages that:
(1) the composite coating is arranged on the surface of the orthopedic implant, and specifically comprises a tantalum metal layer, a bionic calcium phosphate or hydroxyapatite coating and an active functional layer, wherein the tantalum metal improves the wear resistance and corrosion resistance of the implant, the bionic layer effectively improves the bone fusion capability of the orthopedic metal implant, and biological functional molecules and drugs are attached to the surface of the bionic layer, so that the growth of bone tissues can be promoted, and the antibiotic drugs avoid inflammatory reaction.
(2) The preparation process of the composite coating is simple, and only one layer of the outer surface of the tantalum coating is needed; the preparation of the calcium phosphate or the hydroxyapatite adopts a bionic method to prepare the calcium phosphate or the hydroxyapatite, so that a uniform bionic layer can be formed in a complex porous structure, the inner pores of the implant with the porous structure can not be blocked, and the problems of high-temperature energy consumption and hydroxyapatite cracking are avoided; the inner strengthening layer and the bionic layer form a compact coating on the surface of the orthopedic implant substrate, and the coating has high strength and is not easy to crack and fall off.
Drawings
FIG. 1 is a schematic structural diagram of a composite coating for orthopedic implants according to an embodiment of the present invention.
Description of reference numerals:
1. an orthopedic implant; 2. a tantalum metal layer; 3. a biomimetic layer; 4. and an active functional layer.
Detailed Description
In order to more clearly illustrate the technical content of the present invention, the detailed description is given herein with reference to specific examples and drawings, and it is obvious that the examples are only preferred embodiments of the technical solution, and other technical solutions that can be obviously derived by those skilled in the art from the technical content disclosed still belong to the protection scope of the present invention.
In the embodiment of the invention, the chemical reagents used are all analytical grade reagents, and are obtained by purchasing or preparing by an existing method.
In the embodiment of the invention, the multilayer active coating is mainly applied to an orthopedic implant 1, which specifically comprises any one of a fusion device, an acetabular cup, an artificial vertebral body and a filling block, wherein the orthopedic implant material is one of TC4 titanium alloy, pure titanium and cobalt-chromium alloy. The method mainly adopts an additive manufacturing mode, comprises a selective laser melting manufacturing process and an electron beam selective melting technology, and the orthopedic implant is of a porous structure. The multilayer active coating comprises a tantalum metal layer 2, a bionic layer 3 and an active functional layer 4, wherein the bionic layer 3 is a calcium phosphate or hydroxyapatite coating, the active functional layer 4 contains active factors such as bone morphogenetic protein, bone growth factors, antibiotics and the like, and the antibiotics comprise one or more of gentamicin, vancomycin and clindamycin; the multilayer active coating realizes the organic combination of the mechanical property, the biocompatibility and the bone ingrowth property of the coating.
In the embodiment of the invention, the preparation method of the multi-layer active coating of the orthopedic implant specifically comprises the following steps: cleaning an orthopedic implant, installing a magnetron sputtering instrument, adjusting parameters of the magnetron sputtering instrument, vacuumizing and flushing argon, carrying out magnetron sputtering spraying, generating a calcium phosphate (hydroxyapatite) bionic coating, and preparing a functional coating by a dip coating method. The method for preparing the tantalum metal coating by the magnetron sputtering spraying comprises the steps that a cavity protective gas of a magnetron sputtering spraying instrument is high-purity argon with the purity of 99.99 percent, the negative voltage of a cathode is between 260 and 330V, and when a sputtering cavity is vacuumized to be less than 2 x 10-3Pa, argon is filled to 2-5 Pa; the target base spacing was 20 mm.
Example 1
Cleaning the orthopedic implant: cleaning the orthopedic implant after sand blasting, removing oil stains on the surface by using acetone, and performing ultrasonic cleaning by using ethanol as a cleaning agent;
preparing the tantalum metal layer orthopedic implant: installation of a magnetron sputtering spraying instrument: installing the ultrasonically cleaned orthopedic implant and the tantalum metal target material into an instrument cavity; adjusting the position of the orthopedic implant, clamping the orthopedic implant by using a clamp, and adjusting the parameters of a magnetron sputtering spraying instrument: the power supply voltage of the target is 600V, the target material is metal tantalum with the thickness of 400 x 200 x 4mm, and the protective gas is high-purity argon with the purity of 99.99 percent; vacuumizing the sputtering cavity to less than 2 x 10-3Pa, and filling argon to 2-5 Pa; the distance between the target bases is 20 mm; the negative voltage 260-320V is applied to the cathode, Ar ions accelerate to fly to the cathode target under the action of an electric field and bombard the surface of the target at high energy, so that the target is sputtered to impact the surface of the orthopedic implant and is deposited; magnetron sputtering the orthopedic implant for 30-120min, wherein the tantalum coating on the surface of the orthopedic implant is between 3.6-14.4 mu m. In the magnetron sputtering process, when the sputtering distance and the sputtering current are fixed, the thickness of the tantalum coating layer and positive ions (Ar) bombarding the target are constant+) The amount is in direct proportion, the current 5A bombards 100min tantalum coating with the thickness of 12 μm, and the coating is taken out and cooled to 15-25 ℃ after sputtering.
Preparing the bionic-tantalum metal orthopedic implant: preparing a calcium phosphate coating by adopting an immersion method, based on a heterogeneous nucleation principle, immersing the tantalum metal layer orthopedic implant into 0.5M NaOH aqueous solution, immersing for 24h at 60 ℃ for surface activation, taking out, cleaning with deionized water, preparing supersaturated calcium phosphate solution 1L, immersing the activated tantalum metal layer orthopedic implant in saturated calcium phosphate solution in a constant temperature oscillator at 37 ℃ for 2h to generate an amorphous calcium phosphate film, taking out the bone implant with a plurality of layers of active coatings, and naturally drying.
Preparation of the multi-layer active coating of the orthopedic implant: preparing a 1mg/mL gentamicin aqueous solution, dissolving the water-soluble gene recombinant bone morphogenetic protein into an 8mg/mL bone growth factor solution or suspension by using distilled water, and mixing the gentamicin solution and the bone growth factor solution or suspension according to the ratio of 1: 1, spraying the mixed fusion to a bone implant with a multilayer active coating by using an ultrasonic spraying instrument, and airing the bone implant at room temperature to obtain the bone implant with the multilayer active coating.
Example 2
Cleaning the orthopedic implant: cleaning the orthopedic implant after sand blasting, removing oil stains on the surface by using acetone, and performing ultrasonic cleaning by using ethanol as a cleaning agent;
preparing the tantalum metal layer orthopedic implant: installation of a magnetron sputtering spraying instrument: installing the ultrasonically cleaned orthopedic implant and the tantalum metal target material into an instrument cavity; adjusting the position of the orthopedic implant, clamping the orthopedic implant by using a clamp, and adjusting the parameters of a magnetron sputtering spraying instrument: the power supply voltage of the target is 600V, the target material is metal tantalum with the thickness of 400 x 200 x 4mm, and the protective gas is high-purity argon with the purity of 99.99 percent; vacuumizing the sputtering cavity to less than 2 x 10-3Pa, and filling argon to 2-5 Pa; the distance between the target bases is 20 mm; the negative voltage 260-320V is applied to the cathode, Ar ions accelerate to fly to the cathode target under the action of an electric field and bombard the surface of the target at high energy, so that the target is sputtered to impact the surface of the orthopedic implant and is deposited; magnetron sputtering the orthopedic implant for 30-120min, wherein the tantalum coating on the surface of the orthopedic implant is 10-40 mu m. In the magnetron sputtering process, when the sputtering distance and the sputtering current are fixed, the thickness of the tantalum coating layer and positive ions (Ar) bombarding the target are constant+) The amount is in direct proportion, the current 5A bombards for 60min, the thickness of the tantalum coating is 7.2 mu m, and the tantalum coating is taken out and cooled to 15-25 ℃ after sputtering is finished.
Preparing the bionic-tantalum metal orthopedic implant: preparing a hydroxyapatite coating by adopting a bionic deposition method, placing the tantalum metal layer orthopedic implant in an alkaline dopamine solution in a constant-temperature shaking table for 24 hours, taking out the alkaline dopamine solution, cleaning the alkaline dopamine solution by using deionized water, wherein the concentration of the dopamine solution is 10mmol/L, a pH regulator is a Tris-HCl solution, the pH value is regulated to 8.5, and the temperature of the constant-temperature shaking table is 37 ℃. Placing the cleaned tantalum-coated orthopedic implant in simulated body fluid in a constant-temperature shaking table for 3d, taking out the orthopedic implant, and cleaning the orthopedic implant by using deionized water, wherein the simulated body fluid is 1.5SBF, and the temperature of the constant-temperature shaking table is 37 ℃. activation-OH is a necessary condition for forming a biomimetic layer, and an alkaline heat treatment method is commonly used to treat various metals to form active-OH on the surface thereof.
Preparation of the multi-layer active coating of the orthopedic implant: preparing a 1mg/mL gentamicin aqueous solution, dissolving the water-soluble gene recombinant bone morphogenetic protein into an 8mg/mL bone growth factor solution or suspension by using distilled water, and mixing the gentamicin solution and the bone growth factor solution or suspension according to the ratio of 1: 1, soaking the bone implant with the multilayer active coating in the mixed solution for 2 hours, taking out, and airing at room temperature to obtain the bone implant with the multilayer active coating.
The bone implant coating prepared by the technical scheme of the invention is mainly used for metal porous bone implants, in particular porous titanium bone implant products. The titanium alloy bone implant is easy to wear to generate particles to cause inflammation, the strengthening layer of the coating is strengthened by adopting a tantalum metal coating to improve the wear resistance of the implant, the tantalum coating is prepared by adopting a magnetron sputtering technology, the thickness is only 3.4-14.4 mu m, the porosity of porous tantalum is generally 500 mu m in 200-materials, and the coating thickness can be controlled by magnetron sputtering time; the bionic coating is prepared by adopting a calcium phosphate supersaturated solution or a bionic method, the coating is thin and cannot block pores, the biomineralization performance on the surface of the implant is greatly improved, the hydrophilic performance is improved, and the attachment growth of osteoblasts is facilitated; the outermost coating contains bone growth factors and anti-inflammatory drugs, can realize antibacterial and anti-inflammatory effects after implantation, and simultaneously promotes bone growth into porous gaps to accelerate the healing rate of patients.
The above-mentioned embodiments are only preferred embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered as the technical scope of the present invention, and equivalents and modifications of the technical solutions and concepts of the present invention should be covered by the scope of the present invention.
Claims (8)
1. The multi-layer active coating for the orthopedic implant is applied to the metal bone implant and is characterized by comprising a basal strengthening layer, a bionic layer and an active functional layer;
the basic strengthening layer is a tantalum metal layer;
the bionic layer is a calcium phosphate or hydroxyapatite coating;
the active functional layer is a coating comprising one or more of bone morphogenetic proteins, bone growth factors or antibiotics.
2. The multi-layer active coating for orthopedic implants according to claim 1, wherein the metal bone implant is any one of porous structured intervertebral cage, acetabular cup, artificial vertebral body and filling block, and the material of the metal bone implant is one of TC4 titanium alloy, pure titanium and cobalt chromium alloy.
3. The orthopedic implant multilayer active coating of claim 1, wherein the tantalum metal layer has a thickness of 10-40 μ ι η.
4. The orthopedic implant multilayer active coating of claim 1, wherein the antibiotic is one or more of gentamicin, vancomycin, clindamycin.
5. The preparation method of the multi-layer active coating for the orthopedic implant is characterized by specifically comprising the following steps of:
performing sand blasting treatment and cleaning on the orthopedic implant to obtain a pretreated orthopedic implant;
preparing a tantalum metal layer by adopting a magnetron sputtering spraying method to the pretreated orthopedic implant to obtain a tantalum metal layer orthopedic implant;
activating the tantalum metal layer orthopedic implant by alkali, and introducing a bionic layer by a sol-gel method, plasma spraying, electrochemical deposition or a bionic deposition method to obtain a bionic-tantalum metal orthopedic implant;
and introducing the bionic-tantalum metal orthopedic implant into an active functional layer by adopting a spraying method or a dipping method to obtain the multi-layer active coating of the orthopedic implant.
6. The method for preparing the multilayer active coating for the orthopedic implant according to claim 5, wherein the magnetron sputtering spraying method comprises the following steps:
the protective gas of the cavity of the magnetron sputtering spraying instrument is high-purity argon with the purity of 99.99 percent, the negative voltage of the cathode is between 260 and 330V, and the sputtering cavity is vacuumized to be less than 2 x 10-3When Pa, filling argon to 2-5 Pa; the target base spacing was 20 mm.
7. The method for preparing the multi-layer active coating of the orthopedic implant according to claim 5, wherein the alkali used in the alkali activation process of the tantalum metal layer orthopedic implant is sodium hydroxide or alkaline dopamine.
8. The preparation method of the multi-layer active coating of the orthopedic implant according to claim 5, wherein the step of introducing the biomimetic-tantalum metal orthopedic implant into the active functional layer by adopting a spraying method or a dipping method to obtain the multi-layer active coating of the orthopedic implant specifically comprises the following steps:
preparing an active functional layer solution: adding bone morphogenetic protein or bone growth factor into distilled water to prepare 5-10mg/mL biomacromolecule solution or suspension; adding antibiotics into distilled water to prepare 1-3mg/mL antibiotic water solution;
and mixing the biomacromolecule solution or suspension with an antibiotic aqueous solution, and introducing an active functional layer into the bionic-tantalum metal orthopedic implant by adopting a spraying method or a dipping method.
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